Transregio SFB-TR 84 “Innate Immunity of the Lung: Mechanisms of Pathogen Attack and Host Defence in Pneumonia“


Project Overview 2014 - 2018

SFB-TR 84 "Angeborene Immunität der Lunge: Mechanismen des Pathogenangriffs und der Wirtsabwehr in der Pneumonie"


Area A

Pathogen recognition in the lung and initiation of innate immune response

Area B

Humoral and cell-based bronchoalveolar defence mechanisms

Area C

Control of host response in the bronchoalveolar compartment and strategies for intervention

A1 - Bauer / Opitz

Role of innate immune receptors in preventing hyper-inflammation and promoting repair during bacterial pneumonia

B1 - Zahlten / Suttorp / Hain

Peptidoglycan recognition proteins (PGLYRPs) as regulators of innate immunity in the lung

C1 - Schmeck/ Vingron

MicroRNA in the pathogenesis of Legionella pneumonia

A2 - Wygrecka / Preissner

The role of enolase-1 and extracellular nucleic acids in lung infection and their contribution to innate immune responses and bacterial tropism

B2 - Herold / Pleschka / Wolff

Novel pathways of alveolar epithelial cell injury in influenza virus pneumonia: cellular cross-talks and virus-host interactions

C3 - Mayer / Witzenrath

Resolvin E1 and related lipid mediators programming the resolution of inflammation in pneumonia

A4 - Pillich / Chakraborty

Pathophysiological roles of endoplasmic reticulum stress, autophagy and microvillus inclusion during infection with Streptococcus pneumoniae

B3 - Hackstein / Bauer / Lohmeyer

Development and function of respiratory macrophages and dendritic cell subsets during bacterial pneumonia

C6 - Witzenrath / Weissmann

The Angiopoietin-/Tie-2 system in severe pneumonia

A5 - Opitz / Chaput / Heimesaat

Cross-talk of antimicrobial therapy, microbiota and innate immunity in pneumonia caused by multidrug-resistant Gram-negative bacteria

B5 - Meisel A / Meisel C

Paralysis of pulmonary immunity after cerebral ischemia by parasympathetic nervous system

C7 - Fischer / Müller-Redetzky

Host extracellular nucleic acids in severe pneumonia: Mechanisms and therapeutic approaches with adrenomedullin

A6 - Krasteva-Christ / Kummer

Pathogen recognition by taste receptors and coupling to mucociliary clearance

B6 - Hocke / Hippenstiel

Role of mitochondria for innate immune activation in pneumonia

C8 - Seeberger / Sander

Tuning innate immune responses to augment anti-carbohydrate vaccines against bacterial pneumonia

Area Z: Service Projekte

Z1a - Hocke

“High-end” microscopy in cellular microbiology of the lung

Z1b – Gruber

Experimental histopathology, advanced histomorphometrical digital image analysis, molecular pathology and tissue banking


T1 - Hocke / Hippenstiel / Hassel

High-pressure water jet cutting for long-term intravital microscopy based analysis of innate immune mechanisms of human lung

EN1 - Sander

Regulation of protective pulmonary immunity by innate pathways sensing bacterial viability

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