Transregio SFB-TR 84 “Innate Immunity of the Lung: Mechanisms of Pathogen Attack and Host Defence in Pneumonia“


Projekt Übersicht: 2018 - 2022

SFB-TR 84 "Angeborene Immunität der Lunge: Mechanismen des Pathogenangriffs und der Wirtsabwehr in der Pneumonie"


Area A

Pathogen recognition in the lung and initiation of innate immune response

Area B

Humoral and cell-based bronchoalveolar defense mechanisms

Area C

Control of host response in the bronchoalveolar compartment and strategies for intervention

A1 - Opitz / Diefenbach

Regulation of antibacterial defense in the lung by the alarmin IL-33

B2 - Peteranderl / Wolff

Stabilization of epithelial integrity in influenza virus pneumonia: role of death ligands and their downstream effectors

C1 - Schmeck / Marsico

RNA-mediated regulatory networks in Legionella pneumophila pneumonia

A2 - Wygrecka / Kübler / Hackstein

Coagulation factor XII - a  novel regulator of immune responses and barrier function in pneumonia


A4 - Pillich / Chakraborty / Hippenstiel

Pathophysiological host-pathogen crosstalk of Streptococcus pneumoniae at lung barrier interfaces

B6 - Hocke /Hippenstiel / Antelmann

Bacterial acidification as a new virulence mechanism for immune activation and barrier failure via mitochondrial dysfunction

C6 - Witzenrath / Weissmann

Lung protection in severe pneumonia by means of Tie2 agonism

A5 - Opitz / Chaput / Heimesaat

Cross-talk of antimicrobial therapy, microbiota and innate immunity in pneumonia


C8 - Seeberger / Sander

Novel glyco-conjugate vaccine strategies against bacterial pneumonia

A6 - Kummer / Diefenbach

Pathogen recognition by taste and odorant receptors and coupling to BALT formation and epithelial remodeling

B8 - Hain / Mall

Therapeutic targeting of airway microbiome in mice with cystic fibrosis-like lung disease to prevent lung damage and pneumonia

C9 - Kübler / Suttorp / Witzenrath

Role of CFTR and its downstream signaling in lung barrier failure in pneumonia

A7 - Drosten / Hönzke

Modulation of infection and defense by MERS-coronavirus protein 4b

B9 - Herold / Triantafyllopulou

Regulation of macrophage reprogramming and functional specification in pneumonia

C10 - Sander / Schulte / Bauer

Long non-coding RNAs and RNA editing in antibacterial host defense in the lung

Area Z: Service Projects

Z1a - Hocke

High-end microscopy and digital image analysis in cellular microbiology of the lung

Z1b – Gruber

Experimental histopathology, advanced histomorphometrical digital image analysis, molecular pathology and tissue banking

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