Projekt Übersicht: 2018 - 2022
SFB-TR 84 "Angeborene Immunität der Lunge: Mechanismen des Pathogenangriffs und der Wirtsabwehr in der Pneumonie"
Area A Pathogen recognition in the lung and initiation of innate immune response | Area B Humoral and cell-based bronchoalveolar defense mechanisms | Area C Control of host response in the bronchoalveolar compartment and strategies for intervention |
A1 - Opitz / Diefenbach Regulation of antibacterial defense in the lung by the alarmin IL-33 | B2 - Peteranderl / Wolff Stabilization of epithelial integrity in influenza virus pneumonia: role of death ligands and their downstream effectors | C1 - Schmeck / Marsico RNA-mediated regulatory networks in Legionella pneumophila pneumonia |
A2 - Wygrecka / Kübler / Hackstein Coagulation factor XII - a novel regulator of immune responses and barrier function in pneumonia | ||
A4 - Pillich / Chakraborty / Hippenstiel Pathophysiological host-pathogen crosstalk of Streptococcus pneumoniae at lung barrier interfaces | B6 - Hocke /Hippenstiel / Antelmann Bacterial acidification as a new virulence mechanism for immune activation and barrier failure via mitochondrial dysfunction | C6 - Witzenrath / Weissmann Lung protection in severe pneumonia by means of Tie2 agonism |
A5 - Opitz / Chaput / Heimesaat Cross-talk of antimicrobial therapy, microbiota and innate immunity in pneumonia | C8 - Seeberger / Sander Novel glyco-conjugate vaccine strategies against bacterial pneumonia | |
A6 - Kummer / Diefenbach Pathogen recognition by taste and odorant receptors and coupling to BALT formation and epithelial remodeling | B8 - Hain / Mall Therapeutic targeting of airway microbiome in mice with cystic fibrosis-like lung disease to prevent lung damage and pneumonia | C9 - Kübler / Suttorp / Witzenrath Role of CFTR and its downstream signaling in lung barrier failure in pneumonia |
A7 - Drosten / Hönzke Modulation of infection and defense by MERS-coronavirus protein 4b | B9 - Herold / Triantafyllopulou Regulation of macrophage reprogramming and functional specification in pneumonia | C10 - Sander / Schulte / Bauer Long non-coding RNAs and RNA editing in antibacterial host defense in the lung |
Area Z: Service Projects | |
Z1a - Hocke High-end microscopy and digital image analysis in cellular microbiology of the lung | Z1b – Gruber Experimental histopathology, advanced histomorphometrical digital image analysis, molecular pathology and tissue banking |