Transregio SFB-TR 84 “Innate Immunity of the Lung: Mechanisms of Pathogen Attack and Host Defence in Pneumonia“


SFB-TR 84: 2010 - 2014

SFB-TR 84 "Angeborene Immunität der Lunge: Mechanismen des Pathogenangriffs und der Wirtsabwehr in der Pneumonie"


Area A

Pathogen recognition in the lung and initiation of innate immune response

Area B

Humoral and cell-based bronchoalveolar defence mechanisms

Area C

Control of host response in the bronchoalveolar compartment and strategies for intervention

A1 - Bauer / Opitz

Innate immune recognition of bacterial nucleic acids in pneumonia

B1 - Aly / Suttorp / Hain

Analysis of the role and regulation mechanisms of peptidoglycan recognition peptides (PGLYRPs) in pneumonia

C1 - Schmeck/ Vingron

MicroRNA in the pathogenesis of Legionella pneumonia

A2 - Wygrecka / Preissner

The role of extracellular RNA and RNA-binding proteins in lung infection and inflammation

B2 - Herold / Pleschka / Wolff

Cell-type specific roles of the TRAIL-DR5-axis in influenza virus pneumonia. Impact of viral replication, host defense and pathogenicity

C2 - Hippenstiel / Lohmeyer

Krüppel-like factors as regulators of inflammation in pneumococci pneumonia

A4 - Pillich / Chakraborty

Induction of autophagy by  Streptococcus pneumoniae

B3 - Hackstein / Lohmeyer

Impact of macrophage/dendritic cell subsets on inflammation control in pneumonia caused by Streptococcus and Klebsiella pneumoniae

C3 - Mayer / Witzenrath

Resolvins and other lipid mediators and their role in resolution of inflammation in pneumonia

Area Z:

Service Projekte

B4 - Santoso / Schermully

Novel pathways of neutrophil-endothelial cell interaction in acute bacterial pneumonia: impact on transmigration kinetics and organ failure

C4 - Klötzel / Seifert

Pathogen induced alterations of the Ubiquitin-Proteasome-Systeme (UPS) during innate immune response in the lung

Z1a - Hocke

High end microscopy and digital image analysis in cellular microbiology of the lung

B5 - Meisel A / Meisel C

Paralysis of pulmonary immunity after cerebral ischemia by parasympathetic nervous system

C5 - Hocke / Hippenstiel

Interference of S. pneumoniae and L. pneumophila with glucocorticoid dependent signalling in pulmonary cells and human lungs

Z1b – Gruber

Experimental Histopathology, Morphometry, Molecular Pathology and Tissue Banking

C6 - Witzenrath / Weissmann

The Angiopoietin-/Tie-2 system in severe pneumonia

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