Long non-coding RNAs and RNA editing in antibacterial host defense in the lung (Sander / Schulte / Bauer)
Intricate regulatory networks have evolved to gradually adjust antimicrobial immune responses relative to the detected infectious threat.
Here we will decipher the roles of long non-coding RNAs (lncRNAs) and posttranscriptional RNA-editing in pulmonary innate immune responses. We will
I) dissect the mechanistic implications of selected microbially-induced lncRNAs in pulmonary immunity,
II) identify the molecular basis for the non-redundant function of RNA editing enzymes in alveolar macrophage and dendritic cell differentiation and function, and
III) develop a proof-of-concept interventional approach by targeting major RNA regulators of pulmonary immune responses using novel antisense inhibitors.