Regulation of antibacterial defense in the lung by the alarmin IL-33
(Opitz / Diefenbach )
We plan to examine the precise mechanism by which the alarmin IL-33 negatively regulates the immune response during pneumonia. We will focus on processes that control lung epithelial cell-mediated immunity, regeneration and repair by investigating how IL-33 affects the alveolar epithelium both indirectly as well as directly.
(I) identify the cellular sources of IL-33 during pneumococcal infection;
(II) analyze the effects of IL-33 on (innate) lymphoid cells-mediated antibacterial defense, regeneration and repair;
(III) investigate the effects of IL-33 on epithelial cells, and (IV) test if treatment with recombinant sST2 positively affects antibacterial defense and repair during pneumonia.