Publications
Romero MJ, Yue Q, Singla B, Hamacher J, Sridhar S, Moseley AS, Song C, Mraheil MA, Fischer B, Zeitlinger M, Chakraborty T, Fulton D, Gan L, Annex BH, Csanyi G, Eaton DC, Lucas R.
Direct endothelial ENaC activation mitigates vasculopathy induced by SARS-CoV2 spike protein
Front Immunol 2023 Aug 10;14:1241448. doi: 10.3389/fimmu.2023.1241448. eCollection 2023. https://pubmed.ncbi.nlm.nih.gov/37638055/
Perniss A, Boonen B, Tonack S, Thiel M, Poharkar K, Alnouri MW, Keshavarz M, Papadakis T, Wiegand S, Pfeil U, Richter K, Althaus M, Oberwinkler J, Schütz B, Boehm U, Offermanns S, Leinders-Zufall T, Zufall F, Kummer W.
A succinate/SUCNR1-brush cell defense program in the tracheal epithelium
Sci Adv. 2023 Aug 2;9(31):eadg8842. doi: 10.1126/sciadv.adg8842. Epub 2023 Aug 2. PMID: 37531421 https://pubmed.ncbi.nlm.nih.gov/37531421/
Ryan TAJ, Hooftman A, Rehill AM, Johansen MD, Brien ECO, Toller-Kawahisa JE, Wilk MM, Day EA, Weiss HJ, Sarvari P, Vozza EG, Schramm F, Peace CG, Zotta A, Miemczyk S, Nalkurthi C, Hansbro NG, McManus G, O'Doherty L, Gargan S, Long A, Dunne J, Cheallaigh CN, Conlon N, Carty M, Fallon PG, Mills KHG, Creagh EM, Donnell JSO, Hertzog PJ, Hansbro PM, McLoughlin RM, Wygrecka M, Preston RJS, Zasłona Z, Neill LAJO.
Dimethyl fumarate and 4-octyl itaconate are anticoagulants that suppress Tissue Factor in macrophages via inhibition of Type I Interferon.
Nat Commun. 2023 Jun 14;14(1):3513. doi: 10.1038/s41467-023-39174-1. https://pubmed.ncbi.nlm.nih.gov/37316487/
Vidakovic L, Mikhaleva S, Jeckel H, Nisnevich V, Strenger K, Neuhaus K, Raveendran K, Ben-Moshe NB, Aznaourova M, Nosho K, Drescher A, Schmeck B, Schulte LN, Persat A, Avraham R, Drescher K.
Biofilm formation on human immune cells is a multicellular predation strategy of Vibrio cholerae
Cell. 2023 Jun 8;186(12):2690-2704.e20. doi: 10.1016/j.cell.2023.05.008. https://pubmed.ncbi.nlm.nih.gov/37295405/
Jung AL, Han M, Griss K, Bertrams W, Nell C, Greulich T, Klemmer A, Pott H, Heider D, Vogelmeier CF, Hippenstiel S, Suttorp N, Schmeck B.
Novel protein biomarkers for pneumonia and acute exacerbations in COPD: a pilot study.
Front Med (Lausanne). 2023 Jun 5;10:1180746. doi: 10.3389/fmed.2023.1180746. eCollection 2023. https://pubmed.ncbi.nlm.nih.gov/37342494/
Schwerdtner M, Skalik A, Limburg H, Bierwagen J, Jung AL, Dorna J, Kaufmann A, Bauer S, Schmeck B, Böttcher-Friebertshäuser E.
Expression of TMPRSS2 is up-regulated by bacterial flagellin, LPS, and Pam3Cys in human airway cells.
Life Sci Alliance. 2023 May 19;6(8):e202201813. https://pubmed.ncbi.nlm.nih.gov/37208193/
Laakmann K, Eckersberg JM, Hapke M, Wiegand M, Bierwagen J, Beinborn I, Preußer C, Pogge von Strandmann E, Heimerl T, Schmeck B, Jung AL.
Bacterial extracellular vesicles repress the vascular protective factor RNase1 in human lung endothelial cells.
Cell Commun Signal. 2023 May 15;21(1):111. https://pubmed.ncbi.nlm.nih.gov/37189117/
Nouailles G, Adler JM, Pennitz P, Peidli S, Teixeira Alves LG, Baumgardt M, Bushe J, Voss A, Langenhagen A, Langner C, Martin Vidal R, Pott F, Kazmierski J, Ebenig A, Lange MV, Mühlebach MD, Goekeri C, Simmons S, Xing N, Abdelgawad A, Herwig S, Cichon G, Niemeyer D, Drosten C, Goffinet C, Landthaler M, Blüthgen N, Wu H, Witzenrath M, Gruber AD, Praktiknjo SD, Osterrieder N, Wyler E, Kunec D, Trimpert J.
Live-attenuated vaccine sCPD9 elicits superior mucosal and systemic immunity to SARS-CoV-2 variants in hamsters
Nat Microbiol. 2023 May;8(5):860-874. doi: 10.1038/s41564-023-01352-8.. https://pubmed.ncbi.nlm.nih.gov/37012419/
Pappe E, Hammerich R, Saccomanno J, Sgarbossa T, Pohrt A, Schmidt B, Grah C, Eisenmann S, Holland A, Eggeling S, Stanzel F, Witzenrath M, Hübner RH.
Impact of COVID-19 on Hospital Admissions, Health Status, and Behavioral Changes of Patients with COPD.
Chronic Obstr Pulm Dis. 2023 May 3. doi: 10.15326/jcopdf.2022.0383. https://pubmed.ncbi.nlm.nih.gov/37140947/
Felten M, Dame C, Lachmann G, Spies C, Rubarth K, Balzer F, Kramer A, Witzenrath M.
Circadian rhythm disruption in critically ill patients.
Acta Physiol (Oxf). 2023 May;238(1):e13962. doi: 10.1111/apha.13962. https://pubmed.ncbi.nlm.nih.gov/36916859/
Del Fresno C, Schulte LN, López-Collazo E.
Role of hypoxia-inducible factors in metabolic immune cell adaptation during sepsis.
Front Immunol. 2023 Apr 18;14:1194504. https://pubmed.ncbi.nlm.nih.gov/37143647/
Bierwagen J, Wiegand M, Laakmann K, Danov O, Limburg H, Herbel SM, Heimerl T, Dorna J, Jonigk D, Preußer C, Bertrams W, Braun A, Sewald K, Schulte LN, Bauer S, Pogge von Strandmann E, Böttcher-Friebertshäuser E, Schmeck B, Jung AL.
Bacterial vesicles block viral replication in macrophages via TLR4-TRIF-axis.
Cell Commun Signal. 2023 Mar 28;21(1):65. https://pubmed.ncbi.nlm.nih.gov/36978183/
Jung AL, Møller Jørgensen M, Bæk R, Artho M, Griss K, Han M, Bertrams W, Greulich T, Koczulla R, Hippenstiel S, Heider D, Suttorp N, Schmeck B.
Surface proteome of plasma extracellular vesicles as mechanistic and clinical biomarkers for malaria.
Infection. 2023 Mar 24. doi: 10.1007/s15010-023-02022-x. https://pubmed.ncbi.nlm.nih.gov/36961624/
Asmus E, Karle W, Brack MC, Wittig C, Behrens F, Reinshagen L, Pfeiffer M, Schulz S, Mandzimba-Maloko B, Erfinanda L, Perret PL, Michalick L, Smeele PJ, Lim EHT, van den Brom CE, Vonk ABA, Kaiser T, Suttorp N, Hippenstiel S, Sander LE, Kurth F, Rauch U, Landmesser U, Haghikia A, Preissner R, Bogaard HJ, Witzenrath M, Kuebler WM, Szulcek R, Simmons S.
Cystic fibrosis transmembrane conductance regulator modulators attenuate platelet activation and aggregation in blood of healthy donors and COVID-19 patients.
Eur Respir J. 2023 Mar 23;61(3):2202009. doi: 10.1183/13993003.02009-2022. Print 2023 Mar.PMID: 36958745 https://pubmed.ncbi.nlm.nih.gov/36958745/
Goekeri C, Pennitz P, Groenewald W, Behrendt U, Kirsten H, Zobel CM, Berger S, Heinz GA, Mashreghi MF, Wienhold SM, Dietert K, Dorhoi A, Gruber AD, Scholz M, Rohde G, Suttorp N, Capnetz Study Group, Witzenrath M, Nouailles G.
MicroRNA-223 Dampens Pulmonary Inflammation during Pneumococcal Pneumonia.
Cells. 2023 Mar 21;12(6):959. doi: 10.3390/cells12060959.PMID: 36980300 https://pubmed.ncbi.nlm.nih.gov/36980300/
Baiomy AA, Serry FE, Kadry AA, Yahya G, Doijad S, Mostafa A, Mraheil MA, El-Ganiny AM
Genome Analysis of Pseudomonas aeruginosa Strains from Chronically Infected Patients with High Levels of Persister Formation
Pathogen 2023 Mar 8;12(3):426.
doi: 10.3390/pathogens12030426. https://pubmed.ncbi.nlm.nih.gov/36986348/
Weissfuss C, Wienhold SM, Bürkle M, Gaborieau B, Bushe J, Behrendt U, Bischoff R, Korf IHE, Wienecke S, Dannheim A, Ziehr H, Rohde C, Gruber AD, Ricard JD, Debarbieux L, Witzenrath M, Nouailles G.
Repetitive Exposure to Bacteriophage Cocktails against Pseudomonas aeruginosa or Escherichia coli Provokes Marginal Humoral Immunity in Naïve Mice
Viruses. 2023 Jan 29;15(2):387. doi: 10.3390/v15020387. https://pubmed.ncbi.nlm.nih.gov/36851601/
Baumgardt M, Hülsemann M, Löwa A, Fatykhova D, Hoffmann K, Kessler M, Mieth M, Hellwig K, Frey D, Langenhagen A, Voss A, Obermayer B, Wyler E, Dökel S, Gruber AD, Tölch U, Hippenstiel S, Hocke AC, Hönzke K.
State-of-the-art analytical methods of viral infections in human lung organoids
PLoS One. 2022 Dec 20;17(12):e0276115. doi: 10.1371/journal.pone.0276115. eCollection 2022. https://pubmed.ncbi.nlm.nih.gov/36538516/
Pennitz P, Goekeri C, Trimpert J, Wyler E, Ebenig A, Weissfuss C, Mühlebach MD, Witzenrath M, Nouailles G.
Protocol to dissociate healthy and infected murine- and hamster-derived lung tissue for single-cell transcriptome analysis.
STAR Protoc. 2022 Dec 20;4(1):101957. doi: 10.1016/j.xpro.2022.101957. https://pubmed.ncbi.nlm.nih.gov/36542521/
Al-Karmalawy AA, Soltane R, Abo Elmaaty A, Tantawy MA, Antar SA, Yahya G, Chrouda A, Pashameah RA, Mustafa M, Abu Mraheil M, Mostafa A.
Coronavirus Disease (COVID-19) Control between Drug Repurposing and Vaccination: A Comprehensive Overview
Vaccines (Basel). 2021 Nov 12;9(11):
doi: 10.3390/vaccines9111317. https://pubmed.ncbi.nlm.nih.gov/34835248/
Herbel SM, Moyon L, Christ M, Elsayed EM, Caffrey BE, Malmsheimer S, Grin I, Hoffmann K, Surmann K, Blankenburg S, Jung AL, Herkt CE, Borsò M, Bozdag B, Imhof A, Becker A, Wagner S, Bange G, Völker U, Bertrams W, Marsico A, Schmeck B.
Screening for eukaryotic motifs in Legionella pneumophila reveals Smh1 as bacterial deacetylase of host histones
Virulence 2022 Dec;13(1):2042-2058.
doi: 10.1080/21505594.2022.2149973. https://pubmed.ncbi.nlm.nih.gov/36411449/
Klatt AB, Diersing C, Lippmann J, Mayer-Lambertz S, Stegmann F, Fischer S, Caesar S, Fiocca Vernengo F, Hönzke K, Hocke AC, Ruland J, Witzenrath M, Lepenies B, Opitz B
CLEC12A binds to Legionella pneumophila but has no impact on the host's antibacterial response
Int J Mol Sci. 2023 Feb 15;24(4):3891. doi: 10.3390/ijms24043891.https://pubmed.ncbi.nlm.nih.gov/36835297/
Erfinanda L, Zou L, Gutbier B, Kneller L, Weidenfeld S, Michalick L, Lei D, Reppe K, Teixeira Alves LG, Schneider B, Zhang Q, Li C, Fatykhova D, Schneider P, Liedtke W, Sohara E, Mitchell TJ, Gruber AD, Hocke A, Hippenstiel S, Suttorp N, Olschewski A, Mall MA, Witzenrath M, Kuebler WM
Loss of endothelial CFTR drives barrier failure and edema formation in lung infection and can be targeted by CFTR potentiation
Sci Transl Med. 2022 Dec 7;14(674):eabg8577.
doi: 10.1126/scitranslmed.abg8577. https://pubmed.ncbi.nlm.nih.gov/36475904/
Maschirow L, Suttorp N, Opitz B.
Microbiota-dependent regulation of antimicrobial immunity in the lung
Am J Respir Cell Mol Biol. 2019 Sep;61(3):284-289. doi: 10.1165/rcmb.2019-0101TR. https://pubmed.ncbi.nlm.nih.gov/31059654/
Fiocca Vernengo F, Opitz B.
TBK1's role in bacterial pneumonia: Perhaps more than macrophages and
Am J Respir Cell Mol Biol. 2022 Jun;66(6):596-597. doi: 10.1165/rcmb.2022-0040ED.
https://pubmed.ncbi.nlm.nih.gov/35363998/
Hegazy A, Mostafa I, Elshaier YAMM, Mahmoud SH, Abo Shama NM, Shehata M, Yahya G, Nasr NF, El-Halawany AM, Ali MA, Ali MA, Mraheil MA, El-Shazly AM, Mostafa A
Robust Antiviral Activity of Santonica Flower Extract (Artemisia cina) against Avian and Human Influenza A Viruses: In Vitro and Chemoinformatic Studies.
ACS Omega 2022 Nov 2;7(45):41212-41223. doi: 10.1021/acsomega.2c04867. eCollection 2022 Nov 15. https://pubmed.ncbi.nlm.nih.gov/36406485/
Jones MR, Lingampally A, Ahmadvand N, Chong L, Wu J, Wilhem J, Vazquez-Armendariz AI, Ansari M, Herold S, Ornitz DM, Schiller HB, Chao CM, Zhang JS, Carraro G, Bellusci S.
FGFR2b signalling restricts lineage-flexible alveolar progenitors during mouse lung development and converges in mature alveolar type 2 cells.
Cell Mol Life Sci. 2022 Nov 29;79(12):609. doi: 10.1007/s00018-022-04626-2.
https://pubmed.ncbi.nlm.nih.gov/36445537/
Banovic F, Schulze S, Abu Mraheil M, Hain T, Chakraborty T, Orian-Rousseau V, Moroniak S, Weiss C, Ishikawa H, Schroten H, Adam R, Schwerk C.
Different Involvement of Vimentin during Invasion by Listeria monocytogenes at the Blood-Brain and the Blood-Cerebrospinal Fluid Barriers In Vitro
Int J Mol Sci 2022 Oct 26;23(21):12908.
doi: 10.3390/ijms232112908. https://pubmed.ncbi.nlm.nih.gov/36361697/
Teubner L, Frantz R, La Pietra L, Hudel M, Bazant J, Lochnit G, Eismann L, Kramer G, Chakraborty T, Abu Mraheil M.
SecA2 Associates with Translating Ribosomes and Contributes to the Secretion of Potent IFN-β Inducing RNAs
Int J Mol Sci 2022 Nov 30;23(23):15021.
doi: 10.3390/ijms232315021. https://pubmed.ncbi.nlm.nih.gov/36499346/
Hönzke K, Obermayer B, Mache C, Fathykova D, Kessler M, Dökel S, Wyler E, Baumgardt M, Löwa A, Hoffmann K, Graff P, Schulze J, Mieth M, Hellwig K, Demir Z, Biere B, Brunotte L, Mecate-Zambrano A, Bushe J, Dohmen M, Hinze C, Elezkurtaj S, Tönnies M, Bauer TT, Eggeling S, Tran HL, Schneider P, Neudecker J, Rückert JC, Schmidt-Ott KM, Busch J, Klauschen F, Horst D, Radbruch H, Radke J, Heppner F, Corman VM, Niemeyer D, Müller MA, Goffinet C, Mothes R, Pascual-Reguant A, Hauser AE, Beule D, Landthaler M, Ludwig S, Suttorp N, Witzenrath M, Gruber AD, Drosten C, Sander LE, Wolff T, Hippenstiel S, Hocke AC
Human lungs show limited permissiveness for SARS-CoV-2 due to scarce ACE2 levels but virus-induced expansion of inflammatory macrophages
Eur Respir J. 2022 Dec 1;60(6):2102725. doi: 10.1183/13993003.02725-2021.
https://pubmed.ncbi.nlm.nih.gov/35728978/
Bertrams W, Hönzke K, Obermayer B, Tönnies M, Bauer TT, Schneider P, Neudecker J, Rückert JC, Stiewe T, Nist A, Eggeling S, Suttorp N, Wolff T, Hippenstiel S, Schmeck B, Hocke AC
Transcriptomic comparison of primary human lung cells with lung tissue samples and the human A549 lung cell line highlights cell type specific responses during infections with influenza A virus
Sci Rep 12, 2022 Nov 29;12(1):20608.
doi 10.1038/s41598-022-24792-4. https://pubmed.ncbi.nlm.nih.gov/36446841/
Sauer A, Seeliger B, Jandl K, Erfinanda L, Wilhelm J, Alexopoulos I, Baal N, Birnhuber A, David S, Welte T, Barreto G, Gaertner U, Kwapiszewska G, Seeger W, Kuebler WM, Schaefer L, Wygrecka M; members of the CAPNETZ Study Group.
Circulating hyaluronic acid signature in CAP and ARDS - the role of pneumolysin in hyaluronic acid shedding
Matrix Biol. 2022 Dec;114:67-83. doi: 10.1016/j.matbio.2022.11.003. Epub 2022 Nov 16. https://pubmed.ncbi.nlm.nih.gov/36456058/
Lingscheid T, Kinzig M, Krüger A, Müller N, Bölke G, Tober-Lau P, Münn F, Kriedemann H, Witzenrath M, Sander LE, Sörgel F, Kurth F.
Pharmacokinetics of Nirmatrelvir and Ritonavir in COVID-19 Patients with End-Stage Renal Disease on Intermittent Hemodialysis.
Antimicrob Agents Chemother. 2022 Nov 15;66(11):e0122922. doi: 10.1128/aac.01229-22. https://pubmed.ncbi.nlm.nih.gov/36286542/
Wagner C, Balazs A, Schatterny J, Zhou-Suckow Z, Duerr J, Schultz C, Mall MA.
Genetic Deletion of Mmp9 Does Not Reduce Airway Inflammation and Structural Lung Damage in Mice with Cystic Fibrosis-like Lung Disease.
Int J Mol Sci. 2022 Nov 2;23(21):13405. doi: 10.3390/ijms232113405. https://pubmed.ncbi.nlm.nih.gov/36362203/
Ni B, Chen S, Ryan KA, Maitland ML, Farrar JS, Witzenrath M, Gubier B, Serdjebi C, Bertotti K, Wang R, Salloum FN, Marino L, Mitchell BD, Celi FS.
Selective adipocyte loss of Angiopoietin-2 prompts female-specific obesity and metabolic syndrome.
Mol Metab. 2022 Nov;65:101588. doi: 10.1016/j.molmet.2022.101588. https://pubmed.ncbi.nlm.nih.gov/36055577/
Lopez Krol A, Nehring HP, Krause FF, Wempe A, Raifer H, Nist A, Stiewe T, Bertrams W, Schmeck B, Luu M, Leister H, Chung HR, Bauer UM, Adhikary T, Visekruna A.
Lactate induces metabolic and epigenetic reprogramming of pro-inflammatory Th17 cells
EMBO Rep. 2022 Oct 10;e54685. doi: 10.15252/embr.202254685. https://pubmed.ncbi.nlm.nih.gov/36215678/
Kimmig LM, Rako ZA, Ziegler S, Richter MJ, G S AT, Roller F, Grimminger F, Vadász I, Seeger W, Herold S, Tello K, Matt U.
Long-term comprehensive cardiopulmonary phenotyping of COVID-19.
Respir Res. 2022 Sep 21;23(1):263. doi: 10.1186/s12931-022-02173-9. https://pubmed.ncbi.nlm.nih.gov/36131349/
Lask A, Gutbier B, Kershaw O, Nouailles G, Gruber AD, Müller-Redetzky HC, Chackowicz S, Hamilton DA, Van Slyke P, Witzenrath M.
Adjunctive therapy with the Tie2 agonist Vasculotide reduces pulmonary permeability in Streptococcus pneumoniae infected and mechanically ventilated mice
Sci Rep. 2022 Sep 15;12(1):15531. doi: 10.1038/s41598-022-19560-3 https://pubmed.ncbi.nlm.nih.gov/36109537/
Martin TR, Zemans RL, Ware LB, Schmidt EP, Riches DWH, Bastarache L, Calfee CS, Desai TJ, Herold S, Hough CL, Looney MR, Matthay MA, Meyer N, Parikh SM, Stevens T, Thompson BT.
New Insights into Clinical and Mechanistic Heterogeneity of the Acute Respiratory Distress Syndrome: Summary of the Aspen Lung Conference 2021.
Am J Respir Cell Mol Biol. 2022 Sep;67(3):284-308. doi: 10.1165/rcmb.2022-0089WS.
https://pubmed.ncbi.nlm.nih.gov/35679511/
Aznaourova M, Schmerer N, Janga H, Zhang Z, Pauck K, Bushe J, Volkers SM, Wendisch D, Georg P, Ntini E, Aillaud M, Gündisch M, Mack E, Skevaki C, Keller C, Bauer C, Bertrams W, Marsico A, Nist A, Stiewe T, Gruber AD, Ruppert C, Li Y, Garn H, Sander LE, Schmeck B, Schulte LN.
Single-cell RNA sequencing uncovers the nuclear decoy lincRNA PIRAT as a regulator of systemic monocyte immunity during COVID-19
Proc Natl Acad Sci USA. 2022 Sep 6;119(36):e2120680119. doi: 10.1073/pnas.2120680119. Epub 2022 Aug 23. https://pubmed.ncbi.nlm.nih.gov/35998224/
Steinbeis F, Knape P, Mittermaier M, Helbig ET, Tober-Lau P, Thibeault C, Lippert LJ, Xiang W, Müller-Plathe M, Steinbrecher S, Meyer HJ, Ring RM, Ruwwe-Glösenkamp C, Alius F, Li Y, Müller-Redetzky H, Uhrig A, Lingscheid T, Grund D, Temmesfeld-Wollbrück B, Suttorp N, Sander LE, Kurth F, Witzenrath M, Zoller T.
Functional limitations 12 months after SARS-CoV-2 infection correlate with initial disease severity: An observational study of cardiopulmonary exercise capacity testing in COVID-19 convalescents.
Respir Med. 2022 Aug 28;202:106968. doi: 10.1016/j.rmed.2022.106968. https://pubmed.ncbi.nlm.nih.gov/36081267/
Kunec D, Osterrieder N, Trimpert J.
Synthetically recoded virus sCPD9 – A tool to accelerate SARS-CoV-2 research under biosafety level 2 conditions
Comput Struct Biotechnol J . 2022;20:4376-4380. doi: 10.1016/j.csbj.2022.08.027. Epub 2022 Aug 13. https://pubmed.ncbi.nlm.nih.gov/35992535/
Hoffmann K, Obermayer B, Hönzke K, Fatykhova D, Demir Z, Löwa A, Alves LGT, Wyler E, Lopez-Rodriguez E, Mieth M, Baumgardt M, Hoppe J, Firsching TC, Tönnies M, Bauer TT, Eggeling S, Tran HL, Schneider P, Neudecker J, Rückert JC, Gruber AD, Ochs M, Landthaler M, Beule D, Suttorp N, Hippenstiel S, Hocke AC, Kessler M.
Human alveolar progenitors generate dual lineage bronchioalveolar organoids
Commun Biol. 2022 Aug 25;5(1):875. doi: 10.1038/s42003-022-03828-5. https://pubmed.ncbi.nlm.nih.gov/36008580/
Hülsemann M, Wiebach J, Drude NI, Kniffert S, Behm L, Hönzke K, Baumgardt M, Hippenstiel S, Hocke AC, Dirnagl U, Tölch U.
Introducing quality measures in an academic research consortium: Lessons and recommendation from implementing an ad hoc quality management system for organ model research
EMBO Rep. 2022 Aug 3;23(8):e55095. doi: 10.15252/embr.202255095. Epub 2022 Jul 25. https://pubmed.ncbi.nlm.nih.gov/35876564/
Pennitz P, Kirsten H, Friedrich VD, Wyler E, Goekeri C, Obermayer B, Heinz GA, Mashreghi MF, Büttner M, Trimpert J, Landthaler M, Suttorp N, Hocke AC, Hippenstiel S, Tönnies M, Scholz M, Kuebler WM, Witzenrath M, Hoenzke K, Nouailles G.
A pulmonologist's guide to perform and analyse cross-species single lung cell transcriptomics
Eur Respir Rev. 2022 Jul 27;31(165):220056. doi: 10.1183/16000617.0056-2022. https://pubmed.ncbi.nlm.nih.gov/35896273/
Schmiedeknecht K, Kaufmann A, Bauer S, Venegas Solis F.
L-lactate as an indicator for cellular metabolic status: An easy and cost-effective colorimetric L-lactate assay
PLoS One. 2022 Jul 22;17(7):e0271818. doi: 10.1371/journal.pone.0271818. https://pubmed.ncbi.nlm.nih.gov/35867690/
Hollenhorst MI, Nandigama R, Evers SB, Gamayun I, Abdel Wadood N, Salah A, Pieper M, Wyatt A, Stukalov A, Gebhardt A, Nadolni W, Burow W, Herr C, Beisswenger C, Kusumakshi S, Ectors F, Kichko TI, Hübner L, Reeh P, Munder A, Wienhold SM, Witzenrath M, Bals R, Flockerzi V, Gudermann T, Bischoff M, Lipp P, Zierler S, Chubanov V, Pichlmair A, König P, Boehm U, Krasteva-Christ G.
Bitter taste signaling in tracheal epithelial brush cells elicits innate immune responses to bacterial infection.
J Clin Invest. 2022; 132(13):e150951. https://pubmed.ncbi.nlm.nih.gov/35503420/
Kheirollahi V, Khadim A, Kiliaris G, Korfei M, Barroso MM, Alexopoulos I, Vazquez-Armendariz AI, Wygrecka M, Ruppert C, Guenther A, Seeger W, Herold S, El Agha E.
Transcriptional Profiling of Insulin-like Growth Factor Signaling Components in Embryonic Lung Development and Idiopathic Pulmonary Fibrosis.
Cells. 2022 Jun 20;11(12):1973. doi: 10.3390/cells11121973. https://pubmed.ncbi.nlm.nih.gov/35741102/
Margaroli C, Horati H, Garratt LW, Giacalone VD, Schofield C, Dittrich AS, Rosenow T, Dobosh BS, Lim HS, Frey DL, Veltman M, Silva GL, Brown MR, Schultz C, Tiddens HAWM, Ranganathan S, Chandler JD, Qiu P, Peng L, Scholte BJ, Mall MA, Kicic A, Guglani L, Stick SM, Janssens HM, Tirouvanziam R.
Macrophage PD-1 associates with neutrophilia and reduced bacterial killing in early cystic fibrosis airway disease
J Cyst Fibros. 2022 Jun 19;S1569-1993(22)00588-4. doi: 10.1016/j.jcf.2022.06.001. https://pubmed.ncbi.nlm.nih.gov/35732550/
Taghizadeh S, Chao CM, Guenther S, Glaser L, Gersmann L, Michel G, Kraut S, Goth K, Koepke J, Heiner M, Vazquez-Armendariz AI, Herold S, Samakovlis C, Weissmann N, Ricci F, Aquila G, Boyer L, Ehrhardt H, Minoo P, Bellusci S, Rivetti S.
FGF10 Triggers De Novo Alveologenesis in a Bronchopulmonary Dysplasia Model: Impact on Resident Mesenchymal Niche Cells.
Stem Cells. 2022 Jun 22;40(6):605-617. doi:10.1093/stmcls/sxac025. https://pubmed.ncbi.nlm.nih.gov/35437594/
Tabeling C, González Calera CR, Lienau J, Höppner J, Tschernig T, Kershaw O, Gutbier B, Naujoks J, Herbert J, Opitz B, Gruber AD, Hocher B, Suttorp N, Heidecke H, Burmester GR, Riemekasten G, Siegert E, Kuebler WM, Witzenrath M.
Endothelin B Receptor Immunodynamics in Pulmonary Arterial Hypertension.
Front Immunol. 2022 Jun 9;13:895501. https://pubmed.ncbi.nlm.nih.gov/35757687/
Dannebaum R, Suwalski P, Asgharian H, Du Zhipei G, Lin H, Weiner J, Holtgrewe M, Thibeault C, Müller M, Wang X, Karadeniz Z, Saccomanno J, Doehn JM, Hübner RH, Hinzmann B, Blüher A, Siemann S, Telman D, Suttorp N, Witzenrath M, Hippenstiel S, Skurk C, Poller W, Sander LE, Beule D, Kurth F, Guettouche T, Landmesser U, Berka J, Luong K; Pa-COVID Study Group, Rubelt F, Heidecker B.
Highly multiplexed immune repertoire sequencing links multiple lymphocyte classes with severity of response to COVID-19.
EClinicalMedicine. 2022 Jun;48:101438. https://pubmed.ncbi.nlm.nih.gov/35600330/
Ahmadvand N, Lingampally A, Khosravi F, Vazquez-Armendariz AI, Rivetti S, Jones MR, Wilhelm J, Herold S, Barreto G, Koepke J, Samakovlis C, Carraro G, Zhang JS, Al Alam D, Bellusci S.
Fgfr2b signaling is essential for the maintenance of the alveolar epithelial type 2 lineage during lung homeostasis in mice.
Cell Mol Life Sci. 2022 May 19;79(6):302. doi: 10.1007/s00018-022-04327-w. https://pubmed.ncbi.nlm.nih.gov/35587837/
Frey DL, Bridson C, Dittrich S, Graeber SY, Stahl M, Wege S, Herth F, Sommerburg O, Schultz C, Dalpke A, Mall MA, Boutin S.
Changes in Microbiome Dominance Are Associated With Declining Lung Function and Fluctuating Inflammation in People With Cystic Fibrosis
Front Microbiol. 2022 May 13;13:885822. doi: 10.3389/fmicb.2022.885822. eCollection 2022. https://pubmed.ncbi.nlm.nih.gov/35633718/
Patrono LV, Vrancken B, Budt M, Düx A, Lequime S, Boral S, Gilbert MTP, Gogarten JF, Hoffmann L, Horst D, Merkel K, Morens D, Prepoint B, Schlotterbeck J, Schuenemann VJ, Suchard MA, Taubenberger JK, Tenkhoff L, Urban C, Widulin N, Winter E, Worobey M, Schnalke T, Wolff T, Lemey P, Calvignac-Spencer S.
Archival influenza virus genomes from Europe reveal genomic variability during the 1918 pandemic
Nat Commun. 2022 May 10;13(1):2314. doi: 10.1038/s41467-022-29614-9. https://pubmed.ncbi.nlm.nih.gov/35538057/
Wyler E, Adler JM, Eschke K, Teixeira Alves G, Peidli S, Pott F, Kazmierski J, Michalick L, Kershaw O, Bushe J, Andreotti S, Pennitz P, Abdelgawad A, Postmus D, Goffinet C, Kreye J, Reincke SM, Prüss H, Blüthgen N, Gruber AD, Kuebler WM, Witzenrath M, Landthaler M, Nouailles G, Trimpert J.
Key benefits of dexamethasone and antibody treatment in COVID-19 hamster models revealed by single-cell transcriptomics
Mol Ther. 2022 May 4;30(5):1952-1965. doi: 10.1016/j.ymthe.2022.03.014. Epub 2022 Mar 24. https://pubmed.ncbi.nlm.nih.gov/35339689/
Vazquez-Armendariz AI, Barroso MM, El Agha E, Herold S.
3D In Vitro Models: Novel Insights into Idiopathic Pulmonary Fibrosis Pathophysiology and Drug Screening.
Cells. 2022 May 2;11(9):1526. doi: 10.3390/cells11091526.
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Lingscheid T, Lippert LJ, Hillus D, Kruis T, Thibeault C, Helbig ET, Tober-Lau P, Pfäfflin F, Müller-Redetzky H, Witzenrath M, Zoller T, Uhrig A, Opitz B, Suttorp N, Kramer TS, Sander LE, Stegemann MS, Kurth F.
Characterization of antimicrobial use and co-infections among hospitalized patients with COVID-19: a prospective observational cohort study.
Infection. 2022 Apr 14:1-12. https://pubmed.ncbi.nlm.nih.gov/35420370/
Loske J, Röhmel J, Lukassen S, Stricker S, Magalhães VG, Liebig J, Chua RL, Thürmann L, Messingschlager M, Seegebarth A, Timmermann B, Klages S, Ralser M, Sawitzki B, Sander LE, Corman VM, Conrad C, Laudi S, Binder M, Trump S, Eils R, Mall MA, Lehmann I.
Pre-activated antiviral innate immunity in the upper airways controls early SARS-CoV-2 infection in children
Nat Biotechnol. 2022 Mar;40(3):319-324. doi: 10.1038/s41587-021-01037-9. Epub 2021 Aug 18. https://pubmed.ncbi.nlm.nih.gov/34408314/
Zhu L, Duerr J, Zhou-Suckow Z, Wagner W, Weinheimer O, Salomon J, Leitz D, Konietzke P, Yu H, Ackermann M, Stiller W, Kauczor HU, Mall MA, Wielpütz MO.
µCT to quantify muco-obstructive lung disease and effects of neutrophil elastase knockout in mice
Am J Physiol Lung Cell Mol Physiol. 2022 Mar 1;322(3):L401-L411. doi: 10.1152/ajplung.00341.2021. Epub 2022 Jan 26. https://pubmed.ncbi.nlm.nih.gov/35080183/
Sauerhering L, Kuznetsova I, Kupke A, Meier L, Halwe S, Rohde C, Schmidt J, Morty RE, Danov O, Braun A, Vadász I, Becker S, Herold S.
Cyclosporin A Reveals Potent Antiviral Effects in Preclinical Models of SARS-CoV-2 Infection
Am J Respir Crit Care Med. 2022 Feb 15. doi: 10.1164/rccm.202108-1830LE. Online ahead of print. https://pubmed.ncbi.nlm.nih.gov/35167409/
Kaplonek P, Yao L, Reppe K, Voß F, Kohler T, Ebner F, Schäfer A, Blohm U, Priegue P, Bräutigam M, Pereira CL, Parameswarappa SG, Emmadi M, Ménová P, Witzenrath M, Hammerschmidt S, Hartmann S, Sander LE, Seeberger PH.
A semisynthetic glycoconjugate provides expanded cross-serotype protection against Streptococcus pneumoniae
Vaccine. 2022 Feb 11;40(7):1038-1046. doi: 10.1016/j.vaccine.2021.12.068. Epub 2022 Jan 13. pubmed.ncbi.nlm.nih.gov/35033388/
Wygrecka M, Birnhuber A, Seeliger B, Michalick L, Pak O, Schultz AS, Schramm F, Zacharias M, Gorkiewicz G, David S, Welte T, Schmidt JJ, Weissmann N, Schermuly RT, Barreto G, Schaefer L, Markart P, Brack MC, Hippenstiel S, Kurth F, Sander LE, Witzenrath M, Kuebler WM, Kwapiszewska G, Preissner KT.
Altered fibrin clot structure and dysregulated fibrinolysis contribute to thrombosis risk in severe COVID-19
Blood Adv. 2022 Feb 8;6(3):1074-1087. doi: 10.1182/bloodadvances.2021004816. pubmed.ncbi.nlm.nih.gov/34861681/
Conrad C, Yildiz D, Cleary SJ, Margraf A, Cook L, Schlomann U, Panaretou B, Bowser JL, Karmouty-Quintana H, Li J, Berg NK, Martin SC, Aljohmani A, Moussavi-Harami SF, Wang KM, Tian JJ, Magnen M, Valet C, Qiu L, Singer JP, Eltzschig HK; CAPSys Study Group, Bertrams W, Herold S, Suttorp N, Schmeck B, Ball ZT, Zarbock A, Looney MR, Bartsch JW.
ADAM8 signaling drives neutrophil migration and ARDS severity
JCI Insight. 2022 Feb 8;7(3):e149870. doi: 10.1172/jci.insight.149870. https://pubmed.ncbi.nlm.nih.gov/35132956/
Georg P, Astaburuaga-García R, Bonaguro L, Brumhard S, Michalick L, Lippert LJ, Kostevc T, Gäbel C, Schneider M, Streitz M, Demichev V, Gemünd I, Barone M, Tober-Lau P, Helbig ET, Hillus D, Petrov L, Stein J, Dey HP, Paclik D, Iwert C, Mülleder M, Aulakh SK, Djudjaj S, Bülow RD, Mei HE, Schulz AR, Thiel A, Hippenstiel S, Saliba AE, Eils R, Lehmann I, Mall MA, Stricker S, Röhmel J, Corman VM, Beule D, Wyler E, Landthaler M, Obermayer B, von Stillfried S, Boor P, Demir M, Wesselmann H, Suttorp N, Uhrig A, Müller-Redetzky H, Nattermann J, Kuebler WM, Meisel C, Ralser M, Schultze JL, Aschenbrenner AC, Thibeault C, Kurth F, Sander LE, Blüthgen N, Sawitzki B; PA-COVID-19 Study Group.
Complement activation induces excessive T cell cytotoxicity in severe COVID-19
Cell. 2022 Feb 3;185(3):493-512.e25. doi: 10.1016/j.cell.2021.12.040. Epub 2021 Dec 28. pubmed.ncbi.nlm.nih.gov/35032429/
Bahrs C, Kesselmeier M, Kolditz M, Ewig S, Rohde G, Barten-Neiner G, Rupp J, Witzenrath M, Welte T, Pletz MW; CAPNETZ Study Group.
A longitudinal analysis of pneumococcal vaccine serotypes in pneumonia patients in Germany
Eur Respir J. 2022 Feb 3;59(2):2102432. doi: 10.1183/13993003.02432-2021. Print 2022 Feb. https://pubmed.ncbi.nlm.nih.gov/34824055/
Obermann HL, Lederbogen II, Steele J, Dorna J, Sander LE, Engelhardt K, Bakowsky U, Kaufmann A, Bauer S.
RNA-Cholesterol Nanoparticles Function as Potent Immune Activators via TLR7 and TLR8
Front Immunol. 2022 Jan 21;12:658895. doi: 10.3389/fimmu.2021.658895. eCollection 2021. https://pubmed.ncbi.nlm.nih.gov/35126343/
Demichev V, Tober-Lau P, Nazarenko T, Lemke O, Kaur Aulakh S, Whitwell HJ, Röhl A, Freiwald A, Mittermaier M, Szyrwiel L, Ludwig D, Correia-Melo C, Lippert LJ, Helbig ET, Stubbemann P, Olk N, Thibeault C, Grüning NM, Blyuss O, Vernardis S, White M, Messner CB, Joannidis M, Sonnweber T, Klein SJ, Pizzini A, Wohlfarter Y, Sahanic S, Hilbe R, Schaefer B, Wagner S, Machleidt F, Garcia C, Ruwwe-Glösenkamp C, Lingscheid T, Bosquillon de Jarcy L, Stegemann MS, Pfeiffer M, Jürgens L, Denker S, Zickler D, Spies C, Edel A, Müller NB, Enghard P, Zelezniak A, Bellmann-Weiler R, Weiss G, Campbell A, Hayward C, Porteous DJ, Marioni RE, Uhrig A, Zoller H, Löffler-Ragg J, Keller MA, Tancevski I, Timms JF, Zaikin A, Hippenstiel S, Ramharter M, Müller-Redetzky H, Witzenrath M, Suttorp N, Lilley K, Mülleder M, Sander LE; PA-COVID-19 Study group; Kurth F, Ralser M.
A proteomic survival predictor for COVID-19 patients in intensive care.
PLOS Digit Health. 2022 Jan 18;1(1):e0000007. doi: 10.1371/journal.pdig.0000007. https://pubmed.ncbi.nlm.nih.gov/36812516/
Kühnapfel A, Horn K, Klotz U, Kiehntopf M, Rosolowski M, Loeffler M, Ahnert P, Suttorp N, Witzenrath M, Scholz M.
Genetic Regulation of Cytokine Response in Patients with Acute Community-Acquired Pneumonia.
Genes (Basel). 2022 Jan 6;13(1):111. https://pubmed.ncbi.nlm.nih.gov/35052452/
Wienhold SM, Brack MC, Nouailles G, Krishnamoorthy G, Korf IHE, Seitz C, Wienecke S, Dietert K, Gurtner C, Kershaw O, Gruber AD, Ross A, Ziehr H, Rohde M, Neudecker J, Lienau J, Suttorp N, Hippenstiel S, Hocke AC, Rohde C, Witzenrath M.
Preclinical Assessment of Bacteriophage Therapy against Experimental Acinetobacter baumannii Lung Infection.
Viruses. 2021 Dec 24;14(1):33. https://pubmed.ncbi.nlm.nih.gov/35062236/
Letsiou E, Teixeira Alves LG, Felten M, Mitchell TJ, Müller-Redetzky HC, Dudek SM, Witzenrath M.
Neutrophil-Derived Extracellular Vesicles Activate Platelets after Pneumolysin Exposure.
Cells. 2021;10(12):3581. https://pubmed.ncbi.nlm.nih.gov/34944089/
Wee BA, Alves J, Lindsay DSJ, Klatt AB, Sargison FA, Cameron RL, Pickering A, Gorzynski J, Corander J, Marttinen P, Opitz B, Smith AJ, Fitzgerald JR.
Population analysis of Legionella pneumophila reveals a basis for resistance to complement-mediated killing
Nat Commun. 2021 Dec 9;12(1):7165. doi: 10.1038/s41467-021-27478-z. https://pubmed.ncbi.nlm.nih.gov/34887398/
Metzger MI, Graeber SY, Stahl M, Sommerburg O, Mall MA, Dalpke AH, Boutin S.
A Volatile and Dynamic Longitudinal Microbiome Is Associated With Less Reduction in Lung Function in Adolescents With Cystic Fibrosis
Front Cell Infect Microbiol. 2021 Dec 6;11:763121. doi: 10.3389/fcimb.2021.763121. eCollection 2021. https://pubmed.ncbi.nlm.nih.gov/34938669/
Trimpert J, Adler JM, Eschke K, Abdelgawad A, Firsching TC, Ebert N, Thao TTN, Gruber AD, Thiel V, Osterrieder N, Kunec D.
Live attenuated virus vaccine protects against SARS-CoV-2 variants of concern B.1.1.7 (Alpha) and B.1.351 (Beta).
Sci Adv. 2021 Dec 3;7(49):eabk0172. doi: 10.1126/sciadv.abk0172. Epub 2021 Dec 1. PMID: 34851677; PMCID: PMC8635430. pubmed.ncbi.nlm.nih.gov/34851677/
Gruber AD, Firsching TC, Trimpert J, Dietert K.
Hamster models of COVID-19 pneumonia reviewed: How human can they be?
Vet Pathol. 2021 Dec 2:3009858211057197. doi: 10.1177/03009858211057197. Epub ahead of print. PMID: 34856819. pubmed.ncbi.nlm.nih.gov/34856819/
Steinbeis F, Thibeault C, Doellinger F, Ring RM, Mittermaier M, Ruwwe-Glösenkamp C, Alius F, Knape P, Meyer HJ, Lippert LJ, Helbig ET, Grund D, Temmesfeld-Wollbrück B, Suttorp N, Sander LE, Kurth F, Penzkofer T, Witzenrath M, Zoller T.
Severity of respiratory failure and computed chest tomography in acute COVID-19 correlates with pulmonary function and respiratory symptoms after infection with SARS-CoV-2: An observational longitudinal study over 12 months.
Respir Med. 2021 Dec 1;191:106709. doi: 10.1016/j.rmed.2021.106709. Epub ahead of print. PMID: 34871947; PMCID: PMC8632363. pubmed.ncbi.nlm.nih.gov/34871947/
Wendisch D, Dietrich O, Mari T, von Stillfried S, Ibarra IL, Mittermaier M, Mache C, Chua RL, Knoll R, Timm S, Brumhard S, Krammer T, Zauber H, Hiller AL, Pascual-Reguant A, Mothes R, Bülow RD, Schulze J, Leipold AM, Djudjaj S, Erhard F, Geffers R, Pott F, Kazmierski J, Radke J, Pergantis P, Baßler K, Conrad C, Aschenbrenner AC, Sawitzki B, Landthaler M, Wyler E, Horst D; Deutsche COVID-19 OMICS Initiative (DeCOI), Hippenstiel S, Hocke A, Heppner FL, Uhrig A, Garcia C, Machleidt F, Herold S, Elezkurtaj S, Thibeault C, Witzenrath M, Cochain C, Suttorp N, Drosten C, Goffinet C, Kurth F, Schultze JL, Radbruch H, Ochs M, Eils R, Müller-Redetzky H, Hauser AE, Luecken MD, Theis FJ, Conrad C, Wolff T, Boor P, Selbach M, Saliba AE, Sander LE.
SARS-CoV-2 infection triggers profibrotic macrophage responses and lung fibrosis.
Cell. 2021 Nov 27:S0092-8674(21)01383-0. doi: 10.1016/j.cell.2021.11.033. Epub ahead of print. PMID: 34914922. pubmed.ncbi.nlm.nih.gov/34914922/
Trimpert J, Herwig S, Stein J, Vladimirova D, Adler JM, Abdelgawad A, Firsching TC, Thoma T, Sehouli J, Osterrieder K, Gruber AD, Sawitzki B, Sander LE, Cichon G.
Deciphering the Role of Humoral and Cellular Immune Responses in Different COVID-19 Vaccines-A Comparison of Vaccine Candidate Genes in Roborovski Dwarf Hamsters.
Viruses. 2021 Nov 16;13(11):2290. doi: 10.3390/v13112290. PMID: 34835096; PMCID: PMC8625836. pubmed.ncbi.nlm.nih.gov/34835096/
Al-Karmalawy AA, Soltane R, Abo Elmaaty A, Tantawy MA, Antar SA, Yahya G, Chrouda A, Pashameah RA, Mustafa M, Abu Mraheil M, Mostafa A.
Coronavirus Disease (COVID-19) Control between Drug Repurposing and Vaccination: A Comprehensive Overview
Vaccines (Basel). 2021 Nov 12;9(11):1317. doi: 10.3390/vaccines9111317. https://pubmed.ncbi.nlm.nih.gov/34835248/
Mahmoud W, Perniss A, Poharkar K, Soultanova A, Pfeil U, Hoek A, Bhushan S, Hain T, Gärtner U, Kummer W.
CXCL13 is expressed in a subpopulation of neuroendocrine cells in the murine trachea and lung.
Cell Tissue Res. 2022 Oct;390(1):35-49. doi: 10.1007/s00441-021-03552-2. pubmed.ncbi.nlm.nih.gov/34762185/
Hey J, Paulsen M, Toth R, Weichenhan D, Butz S, Schatterny J, Liebers R, Lutsik P, Plass C, Mall MA.
Epigenetic reprogramming of airway macrophages promotes polarization and inflammation in muco-obstructive lung disease
Nat Commun. 2021 Nov 11;12(1):6520. doi: 10.1038/s41467-021-26777-9. pubmed.ncbi.nlm.nih.gov/34764283/
Mösbauer K, Fritsch VN, Adrian L, Bernhardt J, Gruhlke MCH, Slusarenko AJ, Niemeyer D, Antelmann H.
The Effect of Allicin on the Proteome of SARS-CoV-2 Infected Calu-3 Cells.
Front Microbiol. 2021 Oct 28;12:746795. doi: 10.3389/fmicb.2021.746795. PMID: 34777295; PMCID: PMC8581659. pubmed.ncbi.nlm.nih.gov/34777295/
Witkowski M, Tizian C, Ferreira-Gomes M, Niemeyer D, Jones TC, Heinrich F, Frischbutter S, Angermair S, Hohnstein T, Mattiola I, Nawrath P, Mc Ewen S, Zocche S, Viviano E, Heinz GA, Maurer M, Kölsch U, Chua RL, Aschman T, Meisel C, Radke J, Sawitzki B, Roehmel J, Allers K, Moos V, Schneider T, Hanitsch L, Mall MA, Conrad C, Radbruch H, Duerr CU, Trapani JA, Marcenaro E, Kallinich T, Corman VM, Kurth F, Sander LE, Drosten C, Treskatsch S, Durek P, Kruglov A, Radbruch A, Mashreghi MF, Diefenbach A.
Untimely TGFβ responses in COVID-19 limit antiviral functions of NK cells
Nature. 2021 Oct 25. doi: 10.1038/s41586-021-04142-6. Epub ahead of print. PMID: 34695836. pubmed.ncbi.nlm.nih.gov/34695836/
Van Loi V, Busche T, Fritsch VN, Weise C, Gruhlke MCH, Slusarenko AJ, Kalinowski J, Antelmann H.
The two-Cys-type TetR repressor GbaA confers resistance under disulfide and electrophile stress in Staphylococcus aureus.
Free Radic Biol Med. 2021 Oct 19;177:120-131. doi: 10.1016/j.freeradbiomed.2021.10.024. Epub ahead of print. PMID: 34678418. pubmed.ncbi.nlm.nih.gov/34678418/
Schulze J, Mache C, Balázs A, Frey D, Niemeyer D, Olze H, Dommerich S, Drosten C, Hocke AC, Mall MA, Hippenstiel S, Wolff T.
Analysis of SARS-CoV-2 replication in explant cultures of the human upper respiratory tract reveals broad tissue tropism of wild-type and B.1.1.7 variant viruses.
J Infect Dis. 2021 Oct 15:jiab523. doi: 10.1093/infdis/jiab523. Epub ahead of print. PMID: 34651643; PMCID: PMC8524635. pubmed.ncbi.nlm.nih.gov/34651643/
Ehrlich K, Wilhelm J, Markart P, Weisser H, Wolff JC, Bein G, Pak O, Barreto G, Weissmann N, Schramm F, Seeger W, Schaefer L, Kuebler WM, Wygrecka M; and members of the CAPNETZ Study Group.
Sex-specific differences in plasma levels of FXII, HK, and FXIIa-C1-esterase inhibitor complexes in community-acquired pneumonia.
Am J Physiol Lung Cell Mol Physiol. 2021 Oct 1;321(4):L764-L774. doi: 10.1152/ajplung.00162.2021. Epub 2021 Jul 28. PMID: 34318685. pubmed.ncbi.nlm.nih.gov/34318685/
Brox R, Achenbach S, Hackstein H.
Detection of SARS-CoV-2-independent immunoregulatory activity of COVID-19 convalescent plasma.
Transfusion. 2021 Sep 21. doi: 10.1111/trf.16685. Epub ahead of print. PMID: 34546583. pubmed.ncbi.nlm.nih.gov/34546583/
Shaban MS, Müller C, Mayr-Buro C, Weiser H, Meier-Soelch J, Albert BV, Weber A, Linne U, Hain T, Babayev I, Karl N, Hofmann N, Becker S, Herold S, Schmitz ML, Ziebuhr J, Kracht M.
Multi-level inhibition of coronavirus replication by chemical ER stress.
Nat Commun. 2021 Sep 20;12(1):5536. doi: 10.1038/s41467-021-25551-1. PMID: 34545074; PMCID: PMC8452654. pubmed.ncbi.nlm.nih.gov/34545074/
Mermer P, Strotmann J, Kummer W, Paddenberg R.
Olfactory receptor Olfr78 (prostate-specific G protein-coupled receptor PSGR) expression in arterioles supplying skeletal and cardiac muscles and in arterioles feeding some murine organs
Histochem Cell Biol. 2021 Dec;156(6):539-553. doi: 10.1007/s00418-021-02032-6. Epub 2021 Sep 20. https://pubmed.ncbi.nlm.nih.gov/34545457/
Pusch L, Brox R, Scheuer K, Yokosawa T, Wu M, Zubiri BA, Spiecker E, Jandt KD, Fischer D, Hackstein H.
Distinct endocytosis and immune activation of poly(lactic-co-glycolic) acid nanoparticles prepared by single- and double-emulsion evaporation.
Nanomedicine (Lond). 2021 Oct;16(23):2075-2094. doi: 10.2217/nnm-2021-0022. Epub 2021 Sep 15. PMID: 34523349. pubmed.ncbi.nlm.nih.gov/34523349/
Lee S, Yu Y, Trimpert J, Benthani F, Mairhofer M, Richter-Pechanska P, Wyler E, Belenki D, Kaltenbrunner S, Pammer M, Kausche L, Firsching TC, Dietert K, Schotsaert M, Martínez-Romero C, Singh G, Kunz S, Niemeyer D, Ghanem R, Salzer HJF, Paar C, Mülleder M, Uccellini M, Michaelis EG, Khan A, Lau A, Schönlein M, Habringer A, Tomasits J, Adler JM, Kimeswenger S, Gruber AD, Hoetzenecker W, Steinkellner H, Purfürst B, Motz R, Di Pierro F, Lamprecht B, Osterrieder N, Landthaler M, Drosten C, García-Sastre A, Langer R, Ralser M, Eils R, Reimann M, Fan DNY, Schmitt CA.
Virus-induced senescence is a driver and therapeutic target in COVID-19.
Nature. 2021 Nov;599(7884):283-289. doi: 10.1038/s41586-021-03995-1. Epub 2021 Sep 13. PMID: 34517409. pubmed.ncbi.nlm.nih.gov/34517409/
Herta T, Bhattacharyya A, Rosolowski M, Conrad C, Gurtner C, Gruber AD, Ahnert P, Gutbier B, Frey D, Suttorp N, Hippenstiel S, Zahlten J.
Krueppel-Like Factor 4 Expression in Phagocytes Regulates Early Inflammatory Response and Disease Severity in Pneumococcal Pneumonia.
Front Immunol. 2021 Sep 13;12:726135. doi: 10.3389/fimmu.2021.726135. PMID: 34589087; PMCID: PMC8473698. pubmed.ncbi.nlm.nih.gov/34589087/
Schroeder S, Mache C, Kleine-Weber H, Corman VM, Muth D, Richter A, Fatykhova D, Memish ZA, Stanifer ML, Boulant S, Gultom M, Dijkman R, Eggeling S, Hocke A, Hippenstiel S, Thiel V, Pöhlmann S, Wolff T, Müller MA, Drosten C.
Functional comparison of MERS-coronavirus lineages reveals increased replicative fitness of the recombinant lineage 5.
Nat Commun. 2021 Sep 7;12(1):5324. doi: 10.1038/s41467-021-25519-1. PMID: 34493730. pubmed.ncbi.nlm.nih.gov/34493730/
Weiner J, Suwalski P, Holtgrewe M, Rakitko A, Thibeault C, Müller M, Patriki D, Quedenau C, Krüger U, Ilinsky V, Popov I, Balnis J, Jaitovich A, Helbig ET, Lippert LJ, Stubbemann P, Real LM, Macías J, Pineda JA, Fernandez-Fuertes M, Wang X, Karadeniz Z, Saccomanno J, Doehn JM, Hübner RH, Hinzmann B, Salvo M, Blueher A, Siemann S, Jurisic S, Beer JH, Rutishauser J, Wiggli B, Schmid H, Danninger K, Binder R, Corman VM, Mühlemann B, Arjun Arkal R, Fragiadakis GK, Mick E, Comet C, Calfee CS, Erle DJ, Hendrickson CM, Kangelaris KN, Krummel MF, Woodruff PG, Langelier CR, Venkataramani U, García F, Zyla J, Drosten C, Alice B, Jones TC, Suttorp N, Witzenrath M, Hippenstiel S, Zemojtel T, Skurk C, Poller W, Borodina T, Pa-Covid SG, Ripke S, Sander LE, Beule D, Landmesser U, Guettouche T, Kurth F, Heidecker B.
Increased risk of severe clinical course of COVID-19 in carriers of HLA-C*04:01
EClinicalMedicine. 2021 Oct;40:101099. doi: 10.1016/j.eclinm.2021.101099. Epub 2021 Sep 2. PMID: 34490415; PMCID: PMC8410317. pubmed.ncbi.nlm.nih.gov/34490415/
Loyal L, Braun J, Henze L, Kruse B, Dingeldey M, Reimer U, Kern F, Schwarz T, Mangold M, Unger C, Dörfler F, Kadler S, Rosowski J, Gürcan K, Uyar-Aydin Z, Frentsch M, Kurth F, Schnatbaum K, Eckey M, Hippenstiel S, Hocke A, Müller MA, Sawitzki B, Miltenyi S, Paul F, Mall MA, Wenschuh H, Voigt S, Drosten C, Lauster R, Lachman N, Sander LE, Corman VM, Röhmel J, Meyer-Arndt L, Thiel A, Giesecke-Thiel C.
Cross-reactive CD4+ T cells enhance SARS-CoV-2 immune responses upon infection and vaccination.
Science. 2021 Aug 31:eabh1823. doi: 10.1126/science.abh1823. Epub ahead of print. PMID: 34465633. pubmed.ncbi.nlm.nih.gov/34465633/
Linzner N, Antelmann H.
The Antimicrobial Activity of the AGXX® Surface Coating Requires a Small Particle Size to Efficiently Kill Staphylococcus aureus.
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Lancet Respir Med. 2021 Aug 12:S2213-2600(21)00357-X. doi: 10.1016/S2213-2600(21)00357-X. Epub ahead of print. PMID: 34391547; PMCID: PMC8360702. pubmed.ncbi.nlm.nih.gov/34391547/
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Temporal omics analysis in Syrian hamsters unravel cellular effector responses to moderate COVID-19
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A semisynthetic glycoconjugate provides expanded cross-serotype protection against Streptococcus pneumoniae .
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Int J Mol Sci. 2021 Jul 16;22(14):7607. doi: 10.3390/ijms22147607. PMID: 34299227; PMCID: PMC8306112. pubmed.ncbi.nlm.nih.gov/34299227/
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Cell Microbiol. 2021 Jun;23(6):e13322. doi: 10.1111/cmi.13322. Epub 2021 Mar 9. https://pubmed.ncbi.nlm.nih.gov/33629465/
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J Neuroimmunol. 2021 Jun 15;355:577568. doi: 10.1016/j.jneuroim.2021.577568. Epub 2021 Apr 3. PMID: 33862420. pubmed.ncbi.nlm.nih.gov/33862420/
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Cell Syst. 2021 Jun 14:S2405-4712(21)00160-5. doi: 10.1016/j.cels.2021.05.005. Epub ahead of print. PMID: 34139154; PMCID: PMC8201874. pubmed.ncbi.nlm.nih.gov/34139154/
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STAR Protoc. 2021 Jun 11;2(2):100594. doi: 10.1016/j.xpro.2021.100594. PMID: 34169288; PMCID: PMC8209683. pubmed.ncbi.nlm.nih.gov/34169288/
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Adv Drug Deliv Rev. 2021 May 19:S0169-409X(21)00185-X. doi: 10.1016/j.addr.2021.05.021. Epub ahead of print. PMID: 34022269. pubmed.ncbi.nlm.nih.gov/34022269/
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Eur Respir J. 2021 May 13:2100377. doi: 10.1183/13993003.00377-2021. Epub ahead of print. PMID: 33958433; PMCID: PMC8112008. pubmed.ncbi.nlm.nih.gov/33958433/
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Heart failure with preserved ejection fraction according to the HFA-PEFF score in COVID-19 patients: clinical correlates and echocardiographic findings
Eur J Heart Fail. 2021 May 1:10.1002/ejhf.2210. doi: 10.1002/ejhf.2210. Epub ahead of print. PMID: 33932255; PMCID: PMC8239668. pubmed.ncbi.nlm.nih.gov/33932255/
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Tribolium castaneum defensin 1 kills Moraxella catarrhalis in an in vitro infection model but does not harm commensal bacteria
Virulence. 2021 Dec;12(1):1003-1010. doi: 10.1080/21505594.2021.1908741. PMID: 33843461; PMCID: PMC8043168. pubmed.ncbi.nlm.nih.gov/33843461/
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Nat Biotechnol. 2021 Mar 25. doi: 10.1038/s41587-021-00860-4. Online ahead of print. PMID: 33767396. pubmed.ncbi.nlm.nih.gov/33767396/
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CD169/SIGLEC1 is expressed on circulating monocytes in COVID-19 and expression levels are associated with disease severity
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Transcriptional analysis identifies potential biomarkers and molecular regulators in acute malaria infection
Life Sci. 2021 Apr 1;270:119158. doi: 10.1016/j.lfs.2021.119158. Epub 2021 Feb 2. PMID: 33545200. pubmed.ncbi.nlm.nih.gov/33545200/
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Therapeutic Inhibition of Cathepsin S Reduces Inflammation and Mucus Plugging in Adult βENaC-Tg Mice.
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Pro- and anti-tumorigenic capacity of immunoproteasomes in shaping the tumor microenvironment
Cancer Immunol Res. 2021 Mar 11. doi: 10.1158/2326-6066.CIR-20-0492. Epub ahead of print. PMID: 33707310. pubmed.ncbi.nlm.nih.gov/33707310/
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From Clones to Buds and Branches. The Use of Lung Organoids to Mod Branching Morphogenesis Ex Vivo
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Pulmonary fibrosis in Fra-2 transgenic mice is associated with decreased numbers of alveolar macrophages and increased susceptibility to pneumococcal pneumonia
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Streptococcus pneumoniae and Its Virulence Factors H2O2 and Pneumolysin Are Potent Mediators of the Acute Chest Syndrome in Sickle Cell Disease
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Efficient antisense inhibition reveals microRNA-155 to restrain a late-myeloid inflammatory programme in primary human phagocytes
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Front Microbiol. 2021 Feb 3;11:582070. doi: 10.3389/fmicb.2020.582070. PMID: 33613460; PMCID: PMC7887292. pubmed.ncbi.nlm.nih.gov/33613460/
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Plasma mediators in patients with severe COVID-19 cause lung endothelial barrier failure
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A therapeutic non-self-reactive SARS-CoV-2 antibody protects from lung pathology in a COVID-19 hamster model.
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SARS-CoV-2 infection of Chinese hamsters (Cricetulus griseus) reproduces COVID-19 pneumonia in a well-established small animal model
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Detection and segmentation of morphologically complex eukaryotic cells in fluorescence microscopy images via feature pyramid fusion
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Braun J , Loyal L, Frentsch M, Wendisch D , Georg P , Kurth F , Hippenstiel S, Dingeldey M, Kruse B, Fauchere F, Baysal E, Mangold M, Henze L, Lauster R, Mall MA, Beyer K, Röhmel J, Voigt S, Schmitz J, Miltenyi S, Demuth I, Müller MA, Hocke A, Witzenrath M, Suttorp N, Kern F, Reimer U, Wenschuh H, Drosten C, Corman VM, Giesecke-Thiel C, Sander LE, Thiel A
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Messner CB, Demichev V, Wendisch D, Michalick L, White M, Freiwald A, Textoris-Taube K, Vernardis SI, Egger AS, Kreidl M, Ludwig D, Kilian C, Agostini F, Zelezniak A, Thibeault C, Pfeiffer M, Hippenstiel S, Hocke A, von Kalle C, Campbell A, Hayward C, Porteous DJ, Marioni RE, Langenberg C, Lilley KS, Kuebler WM, Mülleder M, Drosten C, Suttorp N, Witzenrath M, Kurth F, Sander LE, Ralser M
Ultra-High-Throughput Clinical Proteomics Reveals Classifiers of COVID-19 Infection
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Age-Dependent Progression of SARS-CoV-2 Infection in Syrian Hamsters
Sauerhering L, Kupke A, Meier L, Dietzel E, Hoppe J, Gruber AD, Gattenloehner S, Witte B, Fink L, Hofmann N, Zimmermann T, Goesmann A, Nist A, Stiewe T, Becker S, Herold S, Peteranderl C.
Cyclophilin Inhibitors Restrict Middle East Respiratory Syndrome Coronavirus Via Interferon λ In Vitro And In Mice
Lorenz Chua R, Lukassen Soeren, Trump S, Hennig BP, Wendisch D, Pott F, Debnath O, Thürmann L, Kurth F, Völker MT, Kazmierski Julia, Timmermann B, Twardziok S, Schneider S, Machleidt F, Müller-Redetzky H , Maier M, Krannich A, Schmidt S, Balzer F, Liebig J, Loske J, Suttorp N, Eils J, Ishaque N, Liebert UG, von Kalle C, Hocke A, Witzenrath M, Goffinet C, Drosten C, Laudi S, Lehmann I, Conrad C, Sander LE, Eils R
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Characterization in mice of the resident mesenchymal niche maintaining AT2 stem cell proliferation in homeostasis and disease.
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Jagdmann S, Dames C, Berchtold D, Winek K, Weitbrecht L, Meisel A, Meisel C.
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Vaccines (Basel). 2020 May 28;8(2):253. doi: 10.3390/vaccines8020253. https://pubmed.ncbi.nlm.nih.gov/32481512/
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Ochs M, Hegermann J, Lopez-Rodriguez E, Timm S, Nouailles G, Matuszak J, Simmons S, Witzenrath M, Kuebler WM.
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Int J Mol Sci. 2020 Apr 27;21(9):3075. doi: 10.3390/ijms21093075.
Duerr J, Leitz DHW, Szczygiel M, Dvornikov D, Fraumann SG Kreutz C, Zadora PK, Seyhan Agircan A Konietzke P, Engelmann TA, Hegermann J, Mulugeta S, Kawabe H, Knudsen L, Ochs M, Rotin D, Muley T, Kreuter M, Herth FJF, Wielpütz MO, Beers MF, Klingmüller U, Mall MA
Conditional deletion of Nedd4-2 in lung epithelial cells causes progressive pulmonary fibrosis in adult mice.
Van Loi V, Antelmann H.
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Perniss A, Liu S, Boonen B, Keshavarz M, Ruppert AL, Timm T, Pfeil U, Soultanova A, Kusumakshi S, Delventhal L, Aydin Ö, Pyrski M, Deckmann K, Hain T, Schmidt N, Ewers C, Günther A, Lochnit G, Chubanov V, Gudermann T, Oberwinkler J, Klein J, Mikoshiba K, Leinders-Zufall T, Offermanns S, Schütz B, Boehm U, Zufall F, Bufe B, Kummer W
Chemosensory Cell-Derived Acetylcholine Drives Tracheal Mucociliary Clearance in Response to Virulence-Associated Formyl Peptides.
Aznaourova M, Janga H, Sefried S, Kaufmann A, Dorna J, Volkers SM, Georg P, Lechner M, Hoppe J, Dökel S, Schmerer N, Gruber AD, Linne U, Bauer S, Sander LE, Schmeck B, Schulte LN
Noncoding RNA MaIL1 is an integral component of the TLR4–TRIF pathway.
Lucas R, Hadizamani Y, Gonzales J, Gorshkov B, Bodmer T, Berthiaume Y, Moehrlen U, Lode H, Huwer H, Hudel M, Mraheil MA, Toque HAF, Chakraborty T, Hamacher J.
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Toxins (Basel). 2020 Apr 2;12(4):223. doi: 10.3390/toxins12040223. https://pubmed.ncbi.nlm.nih.gov/32252376/
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Neutralizing Complement C5a Protects Mice with Pneumococcal Pulmonary Sepsis
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Maternal asthma is associated with persistent changes in allergic offspring antibody glycosylation
Clin Exp Allergy. 2020 Apr;50(4):520-531. doi: 10.1111/cea.13559.
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Phage capsid nanoparticles with defined ligand arrangement block influenza virus entry
Herkt CE, Caffrey BE, Surmann K, Blankenburg S, Gesell Salazar M, Jung AL, Herbel SM, Hoffmann K, Schulte LN, Chen W, Sittka-Stark A, Völker U, Vingron M, Marsico A, Bertrams W, Schmeck B.
A MicroRNA Network Controls Legionella pneumophila Replication in Human Macrophages via LGALS8 and MX1.
Brown R, Paulsen M, Schmidt S, Schatterny J, Frank A, Hirtz S, Delaney R, Doherty D, Hagner M, Taggart C, Weldon S, Mall MA
Lack of IL-1 receptor signaling reduces spontaneous airway eosinophilia in juvenile mice with muco-obstructive lung disease.
Hagner M, Frey DL, Guerra M, Dittrich AS, Halls VS, Wege S, Herth FJF, Schultz C, Mall MA
New method for rapid and dynamic quantification of elastase activity on sputum neutrophils from patients with cystic fibrosis using flow cytometry.
Rohilla S, Krämer B, Koberling F, Gregor I, Hocke AC.
Multi-target immunofluorescence by separation of antibody cross-labelling via spectral-FLIM-FRET
Hotter B, Hoffmann S, Ulm L, Montaner J, Bustamante A, Meisel C, Meisel A.
Inflammatory and stress markers predicting pneumonia, outcome, and etiology in patients with stroke: Biomarkers for predicting pneumonia, functional outcome, and death after stroke
Neurol Neuroimmunol Neuroinflamm. 2020 Feb 25;7(3):e692. doi: 10.1212/NXI.0000000000000692. Print 2020 May. https://pubmed.ncbi.nlm.nih.gov/32098866/
La Pietra L, Hudel M, Pillich H, Abu Mraheil M, Berisha B, Aden S, Hodnik V, Lochnit G, Rafiq A, Perniss A, Anderluh G, Chakraborty T
Phosphocholine antagonizes listeriolysin O-induced host cell responses of Listeria monocytogenes.
Wahl M, Röhlicke T, Kulisch S, Rohilla S, Krämer B, Hocke AC.
Photon arrival time tagging with many channels, sub-nanosecond deadtime, very high throughput, and fiber optic remote synchronization
McKelvey MC, Weldon S, McAuley DF, Mall MA, Taggart CC
Targeting proteases in cystic fibrosis lung disease: Paradigms, progress, and potential.
Bertrams W, Griss K, Han M, Seidel K, Klemmer A, Sittka-Stark A, Hippenstiel S, Suttorp N, Finkernagel F, Wilhelm J, Greulich T, Vogelmeier C, Vera J, Schmeck B
Transcriptional analysis identifies potential biomarkers and molecular regulators in pneumonia and COPD exacerbation.
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The Family of Chloride Channel Regulator, Calcium-activated Proteins in the Feline Respiratory Tract: A Comparative Perspective on Airway Diseases in Man and Animal Models
J Comp Pathol. 2020 Jan;174:39-53. doi: 10.1016/j.jcpa.2019.10.193.
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Cystic fibrosis: Emergence of highly effective targeted therapeutics and potential clinical implications.
Lückel C, Picard F, Raifer H, Campos Carrascosa L, Guralnik A, Zhang Y, Klein M, Bittner S, Steffen F, Moos S, Marini F, Gloury R, Kurschus FC, Chao YY, Bertrams W, Sexl V, Schmeck B, Bonetti L, Grusdat M, Lohoff M, Zielinski CE, Zipp F, Kallies A, Brenner D, Berger M, Bopp T, Tackenberg B, Huber M
IL-17+ CD8+ T cell suppression by dimethyl fumarate associates with clinical response in multiple sclerosis.
Hübner K, Karwelat D, Pietsch E, Beinborn I, Winterberg S, Bedenbender K, Benedikter BJ, Schmeck B, Vollmeister E
NF-κB-mediated inhibition of microRNA-149-5p regulates Chitinase-3-like 1 expression in human airway epithelial cells.
Matos ADR, Wunderlich K, Schloer S, Schughart K, Geffers R, Seders M, Witt M, Christersson A, Wiewrodt R, Wiebe K, Barth P, Hocke A, Hippenstiel S, Hönzke K, Dittmer U, Sutter K, Rescher U, Rodionycheva S, Matera N, Ludwig S, Brunotte L.
Antiviral potential of human IFN-α subtypes against influenza A H3N2 infection in human lung explants reveals subtype-specific activities
Lindhauer N, Bertrams W, Pöppel A, Herkt C, Wesener A, Hoffmann K, Greene B, van der Linden M, Vilcinskas A, Seidel K, Schmeck B.
Antibacterial activity of a Tribolium castaneum defensin in an in vitro infection model of Streptococcus pneumoniae.
Virulence. 2019 Dec10 (1):902-909
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Antioxid Redox Signal. 2019 Dec 1;31(16):1235-1252. doi: 10.1089/ars.2019.7750.
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Pediatr Pulmonol. 2019 Nov;54 Suppl 3:S5-S12.
Jung AL, Møller Jørgensen M, Bæk R, Griss K, Han M, auf dem Brinke K, Timmesfeld N, Bertrams W, Greulich T, Koczulla AR, Hippenstiel S, Suttorp N, Schmeck B.
Surface proteome of plasma extracellular vesicles as biomarkers for pneumonia and acute exacerbation of COPD.
J Infect Dis. 2019 Oct 16. pii: jiz460
Limburg H, Harbig A, Bestle D, Stein DA, Moulton HM, Jaeger J, Janga H, Hardes K, Koepke J, Schulte L, Koczulla AR, Schmeck B, Klenk HD, Böttcher-Friebertshäuser E.
TMPRSS2 is the major activating protease of influenza A virus in primary human airway cells and influenza B virus in human type II pneumocytes.
J Virol. 2019 Oct 15;93(21). pii: e00649-19
Frantz R, Teubner L, Schultze T, La Pietra L, Müller C, Gwozdzinski K, Pillich H, Hain T, Weber-Gerlach M, Panagiotidis GD, Mostafa A, Weber F, Rohde M, Pleschka S, Chakraborty T, Abu Mraheil M.
The secRNome of Listeria monocytogenes Harbors Small Noncoding RNAs That Are Potent Inducers of Beta Interferon.
Dabrowski AN, Shrivastav A, Conrad C, Komma K, Weigel M, Dietert K, Gruber A, Bertrams W, Wilhelm J, Schmeck B, Reppe K, N'Guessan PD, Aly S, Suttorp N, Hain T, Zahlten J.
Peptidoglycan recognition protein 4 limits bacterial clearance and inflammation in lungs by control of the gut microbiota.
Front Immunol. 2019 Sep 20;10:2106
Peteranderl C, Kuznetsova I, Schulze J, Hardt M, Lecuona E, Sznajder JI, Vadász I, Morty RE, Pleschka S, Wolff T, Herold S
Influenza A virus infection induces apical redistribution of Na+, K+-ATPase in lung epithelial cells in vitro and in vivo.
Loi VV, Huyen NTT, Busche T, Tung QN, Gruhlke MCH, Kalinowski J, Bernhardt J, Slusarenko AJ, Antelmann H.
Staphylococcus aureus responds to allicin by global S-thioallylation - Role of the Brx/BSH/YpdA pathway and the disulfide reductase MerA to overcome allicin stress
Free Radic Biol Med. 2019 Aug 1;139:55-69. doi: 10.1016/j.freeradbiomed.2019.05.018.
Lippitsch A, Baal N, Chukovetskyi Y, Cunningham S, Michel G, Dietert K, Gurtner C, Gruber AD, Bein G, Hackstein H
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J Leukoc Biol. 2019 Jul 2
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Staphylococcus aureus Uses the Bacilliredoxin (BrxAB)/Bacillithiol Disulfide Reductase (YpdA) Redox Pathway to Defend Against Oxidative Stress Under Infections
Front Microbiol. 2019 Jun 18;10:1355. doi: 10.3389/fmicb.2019.01355.
Kaßmann M, Szijártó IA, García-Prieto CF, Fan G, Schleifenbaum J, Anistan YM, Tabeling C, Shi Y, le Noble F, Witzenrath M, Huang Y, Markó L, Nelson MT, Gollasch M.
Role of Ryanodine Type 2 Receptors in Elementary Ca2+ Signaling in Arteries and Vascular Adaptive Responses.
J Am Heart Assoc. 2019;8(9):e010090. https://pubmed.ncbi.nlm.nih.gov/31030596/
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When Place Matters: Shuttling of Enolase-1 Across Cellular Compartments.
Front Cell Dev Biol. 2019 Apr 26;7:61
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Intracellular bacteria engage a STING-TBK1-MVB12b pathway to enable paracrine cGAS-STING signalling.
Nat Microbiol. 2019 Apr;4(4):701-713, Epub 2019 Feb 25
Visekruna A, Hartmann S, Sillke YR, Glauben R, Fischer F, Raifer H, Mollenkopf H, Bertrams W, Schmeck B, Klein M, Pagenstecher A, Lohoff M, Jacob R, Pabst O, Bland PW, Luu M, Romero R, Siegmund B, Rajalingam K, Steinhoff U
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J Clin Invest. 2019 Apr 2;130. pii: 98929. eCollection 2019 Apr 2
Baal N, Cunningham S, Obermann HL, Thomas J, Lippitsch A, Dietert K, Gruber AD, Kaufmann A, Michel G, Nist A, Stiewe T, Rupp O, Goesmann A, Zukunft S, Fleming I, Bein G, Lohmeyer J, Bauer S, Hackstein H
ADAR1 Is Required for Dendritic Cell Subset Homeostasis and Alveolar Macrophage Function.
J Immunol. 2019 Feb 15;202(4):1099-1111
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Proviral MicroRNAs Detected in Extracellular Vesicles From Bronchoalveolar Lavage Fluid of Patients With Influenza Virus-Induced Acute Respiratory Distress Syndrome.
J Infect Dis. 2019 Jan 29;219(4):540-543
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Kaplonek P, Khan N, Reppe K, Schumann B, Emmadi M, Lisboa MP, Xu FF, Calow ADJ, Parameswarappa SG, Witzenrath M, Pereira CL, Seeberger PH.
Improving vaccines against Streptococcus pneumoniae using synthetic glycans.
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Acute Moraxella catarrhalis infection of chronically smoke-exposed mice increases mechanisms of emphysema development: a pilot study.
Eur J Microbiol Immunol (Bp.) 2018;8(4):128-134. https://pubmed.ncbi.nlm.nih.gov/30719329/
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Front Neurol. 2018 Nov 19;9:937. doi: 10.3389/fneur.2018.00937. eCollection 2018. https://pubmed.ncbi.nlm.nih.gov/30510535/
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Delay in antibiotic therapy results in fatal disease outcome in murine pneumococcal pneumonia.
Crit Care 2018;22(1):287. https://pubmed.ncbi.nlm.nih.gov/30382866/
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Ventilator-induced lung injury is aggravated by antibiotic mediated microbiota depletion in mice.
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Factor XII in coagulation, inflammation and beyond.
Grund C, Hoffmann D, Ulrich R, Naguib M, Schinköthe J, Hoffmann B, Harder T, Saenger S, Zscheppang K, Tönnies M, Hippenstiel S, Hocke A, Wolff T, Beer M.
A novel European H5N8 influenza A virus has increased virulence in ducks but low zoonotic potential
Robak OH, Heimesaat MM, Kruglov AA, Prepens S, Ninnemann J, Gutbier B, Reppe K, Hochrein H, Suter M, Kirschning CJ, Marathe V, Buer J, Hornef MW, Schnare M, Schneider P, Witzenrath M, Bereswill S, Steinhoff U, Suttorp N, Sander LE, Chaput C, Opitz B
Antibiotic treatment-induced secondary IgA deficiency enhances susceptibility to Pseudomonas aeruginosa pneumonia.
J Clin Invest. 2018 Jul 16. pii: 97065
Kalymbetova TV, Selvakumar B, Rodriguez-Castillo JA, Gunjak M, Malainou C, Heindl MR, Moiseenko A, Chao CM, Vadasz I, Mayer K, Lohmeyer J, Bellusci S, Bottcher-Friebertshauser E, Seeger W, Herold S, Morty RE
Resident alveolar macrophages are master regulators of arrested alveolarization in experimental bronchopulmonary dysplasia.
J Pathol. 2018 Jun;245(2):153-159
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Cystathionine gamma-Lyase-Produced Hydrogen Sulfide Controls Endothelial NO Bioavailability and Blood Pressure.
Hypertension. 2018;71(6):1210-1217. https://pubmed.ncbi.nlm.nih.gov/29712741/
Keshavarz M, Skill M, Hollenhorst MI, Pfeil U, Walecki M, Kummer W, Krasteva-Christ G
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Sci Rep. 2018 May 14;8(1)
Zakrzewicz D, Didiasova M, Krüger M, Giaimo BD, Borggrefe T, Mieth M, Hocke AC, Zakrzewicz A, Schaefer L, Preissner KT, Wygrecka M
Protein arginine methyltransferase 5 mediates enolase-1 cell surface trafficking in human lung adenocarcinoma cells.
Biochim Biophys Acta. 2018 May;1864(5 Pt A):1816-1827
Herta T, Bhattacharyya A, Bollensdorf C, Kabus C, García P, Suttorp N, Hippenstiel S, Zahlten J
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Sci Rep. 2018 Apr 10;8(1):5723
Perniss A, Schmidt N, Gurtner C, Dietert K, Schwengers O, Weigel M, Hempe J, Ewers C, Pfeil U, Gärtner U, Gruber AD, Hain T, Kummer W
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Fisetin protects against Listeria monocytogenes infection by reducing the listeriolysin O production.
J Infect Dis. 2015; pii:jiv437.
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Meisel A, Smith CJ
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Lancet. 2015 Sep 3. pii: S0140-6736(15)00127-0
Fatykhova D, Rabes A, Machnik C, Guruprasad K, Pache F, Berg J, Toennies M, Bauer TT, Schneider P, Schimek M, Eggeling S, Mitchell TJ, Mitchell AM, Hilker R, Hain T, Suttorp N, Hippenstiel S, Hocke AC, Opitz B
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PLoS One. 2015 Aug 28;10(8):e0137108
Gutbier B, Fischer K, Doehn JM, von Lachner C, Herr C, Klaile E, Frischmann U, Singer BB, Riesbeck K, Zimmermann W, Suttorp N, Bachmann S, Bals R, Witzenrath M, Slevogt H
Moraxella catarrhalis induces an immune response in the murine lung that is independent of human CEACAM5 expression and long-term smoke exposure.
Am J Physiol Lung Cell Mol Physiol. 2015 Aug 1;309(3):L250-61
Recum-Knepper J, Sadewasser A, Weinheimer VK, Wolff T
Fluorescence-Activated Cell Sorting-Based Analysis Reveals an Asymmetric Induction of Interferon-Stimulated Genes in Response to Seasonal Influenza A Virus.
J Virol. 2015 Jul 15;89(14):6982-93
Soultanova A, Voigt A, Chubanov V, Gudermann T, Meyerhof W, Boehm U, Kummer W
Cholinergic chemosensory cells of the thymic medulla express the bitter receptor Tas2r131.
Int Immunopharmacol. 2015 Nov;29(1):143-7
Mühlbauer D, Dzieciolowski J, Hardt M, Hocke A, Schierhorn KL, Mostafa A, Müller C, Wisskirchen C, Herold S, Wolff T, Ziebuhr J, Pleschka S
Influenza virus-induced caspase-dependent enlargement of nuclear pores promotes nuclear export of viral ribonucleoprotein complexes.
J Virol. 2015 Jun 1;89(11):6009-21
Jung S, von Thulen T, Laukemper V, Pigisch S, Hangel D, Wagner H, Kaufmann A, Bauer S
A single naturally occurring 2'-O-methylation converts a TLR7- and TLR8-activating RNA into a TLR8-specific ligand.
A single naturally occurring 2'-O-methylation converts a TLR7- and TLR8-activating RNA into a TLR8-specific ligand.
Hecker M, Linder T, Ott J, Walmrath HD, Lohmeyer J, Vadász I, Marsh LM, Herold S, Reichert M, Buchbinder A, Morty RE, Bausch B, Fischer T, Schulz R, Grimminger F, Witzenrath M, Barnes M, Seeger W, Mayer K
Immunomodulation by lipid emulsions in pulmonary inflammation: a randomized controlled trial.
Crit Care. 2015 May 12;19:226
Müller-Redetzky HC, Wienhold SM, Berg J, Hocke AC, Hippenstiel S, Hellwig K, Gutbier B, Opitz B, Neudecker J, Rückert J, Gruber AC, Kershaw O, Mayer K, Suttorp N, Witzenrath M
Moxifloxacin is not anti-inflammatory in experimental pneumococcal pneumonia.
J Antimicrob Chemother. 2015 Mar;70(3):830-40
Kishore AK, Vail A, Chamorro A, Garau J, Hopkins SJ, Di Napoli M, Kalra L, Langhorne P, Montaner J, Roffe C, Rudd AG, Tyrrell PJ, van de Beek D, Woodhead M, Meisel A, Smith CJ
How is pneumonia diagnosed in clinical stroke research? A systematic review and meta-analysis.
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Tabeling C, Yu H, Wang L, Ranke H, Goldenberg NM, Zabini D, Noe E, Krauszman A, Gutbier B, Yin J, Schaefer M, Arenz C, Hocke AC, Suttorp N, Proia RL, Witzenrath M, Kuebler WM
CFTR and sphingolipids mediate hypoxic pulmonary vasoconstriction.
Proc Natl Acad Sci U S A. 2015 Mar 31;112(13):E1614-23
Didiasova M, Zakrzewicz D, Magdolen V, Nagaraj C, Bálint Z, Rohde M, Preissner KT, Wygrecka M
STIM1/ORAI1-mediated Ca2+ Influx Regulates Enolase-1 Exteriorization.
J Biol Chem. 2015 May 8;290(19):11983-99
Zahlten J, Herta T, Kabus C, Steinfeldt M, Kershaw O, García P, Hocke AC, Gruber AD, Hübner RH, Steinicke R, Doehn JM, Suttorp N, Hippenstiel S
Pneumococci LytA-dependent KLF4 Expression Terminates IL-8 Secretion in Lung Epithelium.
Am J Respir Cell Mol Biol. 2015 Mar 10
Dietert K, Mundhenk L, Erickson NA, Reppe K, Hocke AC, Kummer W, Witzenrath M, Gruber AD
Murine CLCA5 is uniquely expressed in distinct niches of airway epithelial cells.
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Rabes A, Zimmermann S, Reppe K, Lang R, Seeberger PH, Suttorp N, Witzenrath M, Lepenies B, Opitz B
The C-type lectin receptor Mincle binds to Streptococcus pneumoniae but plays a limited role in the anti-pneumococcal innate immune response.
PLoS One. 2015 Feb 6;10(2):e0117022
Müller-Redetzky HC, Felten M, Hellwig K, Wienhold SM, Naujoks J, Opitz B, Kershaw O, Gruber AD, Suttorp N, Witzenrath M
Increasing the inspiratory time and I:E ratio during mechanical ventilation aggravates ventilator-induced lung injury in mice.
Critical Care 2015, 19:23
Loose M, Hudel M, Zimmer KP, Garcia E, Hammerschmidt S, Lucas R, Chakraborty T, Pillich H
Pneumococcal hydrogen peroxide-induced stress signaling regulates inflammatory genes.
J Infect Dis. 2015 Jan 15;211(2):306-16
Zahlten J, Kim YJ, Doehn JM, Pribyl T, Hocke AC, García P, Hammerschmidt S, Suttorp N, Hippenstiel S, Hübner RH
Streptococcus pneumoniae-Induced Oxidative Stress in Lung Epithelial Cells Depends on Pneumococcal Autolysis and Is Reversible by Resveratrol.
J Infect Dis. 2015 Jun 1;211(11):1822-1830
Dames C, Akyüz L, Reppe K, Tabeling C, Dietert K, Kershaw O, Gruber AD, Meisel C, Meisel A, Witzenrath M, Engel O
Miniaturized bronchoscopy enables unilateral investigation, application, and sampling in mice.
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Conrad T, Marsico A, Gehre M, Orom UA
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A novel tumor necrosis factor-mediated mechanism of direct epithelial sodium channel activation.
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Ann Anat. 2014 Sep;196(5):365-71
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Respir Res. 2014 Aug 5;15:85
Heine G, Tabeling C, Hartmann B, González Calera CR, Kühl AA, Lindner J, Radbruch A, Witzenrath M, Worm M
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J Immunol. 2014 Aug 1;193(3)
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Front Physiol. 2014; 5:259.
Witzenrath M
Endothelial progenitor cells for acute respiratory distress syndrome treatment: support your local sheriff!
Am J Respir Crit Care Med. 2014 Jun 15;189(12):1452-5
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Structural and functional prevention of hypoxia-induced pulmonary hypertension by individualized exercise training in mice.
Am J Physiol Lung Cell Mol Physiol. 2014 Jun 1;306(11):L986-95
Zakrzewicz D, Didiasova M, Zakrzewicz A, Hocke AC, Uhle F, Markart P, Preissner KT, Wygrecka M
The interaction of enolase-1 with caveolae-associated proteins regulates its subcellular localization.
Biochem J. 2014 Jun 1;460(2):295-307
Tabeling C, Scheer H, Schönrock SM, Runge F, Gutbier B, Lienau J, Hamelmann E, Opitz B, Suttorp N, Mayer K, Behrens GM, Tschernig T, Witzenrath M
Nucleotide oligomerization domain 1 ligation suppressed murine allergen-specific T-cell proliferation and airway hyperresponsiveness.
Am J Respir Cell Mol Biol. 2014 May;50(5):903-11
Hecker M, Ott J, Sondermann C, Schaefer M, Obert M, Hecker A, Morty RE, Vadasz I, Herold S, Rosengarten B, Witzenrath M, Seeger W, Mayer K
Immunomodulation by fish-oil containing lipid emulsions in murine acute respiratory distress syndrome.
Crit Care. 2014 Apr 29;18(2):R85
Müller-Redetzky HC, Will D, Hellwig K, Kummer W, Tschernig T, Pfeil U, Paddenberg R, Menger MD, Kershaw O, Gruber AD, Weissmann N, Hippenstiel S, Suttorp N, Witzenrath M
Mechanical ventilation drives pneumococcal pneumonia into lung injury and sepsis in mice: protection by adrenomedullin.
Crit Care. 2014 Apr 14;18(2):R73.
Krljanac B, Weih D, Jacobsen ID, Hu D, Koliesnik I, Reppe K, Witzenrath M, Weih F.
NF-κB2/p100 deficiency impairs immune responses to T-cell-independent type 2 antigens.
Eur J Immunol. 2014 Mar;44(3):662-72
Müller-Redetzky HC, Suttorp N, Witzenrath M
Dynamics of pulmonary endothelial barrier function in acute inflammation: mechanisms and therapeutic perspectives.
Cell Tissue Res. 2014 Mar;355(3):657-73
Kill A, Tabeling C, Undeutsch R, Kühl AA, Günther J, Radic M, Becker MO, Heidecke H, Worm M, Witzenrath M, Burmester GR, Dragun D, Riemekasten G
Autoantibodies to angiotensin and endothelin receptors in systemic sclerosis induce cellular and systemic events associated with disease pathogenesis.
Arthritis Res Ther. 2014 Jan 28;16(1):R29
Herold S, Hoegner K, Vadász I, Gessler T, Wilhelm J, Mayer K, Morty RE, Walmrath
Inhaled GM-CSF as treatment of pneumonia-associated ARDS
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Classical Transient Receptor Potential Channel 1 in Hypoxia-induced Pulmonary Hypertension.
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Tabeling C, Scheer H, Schönrock SM, Runge F, Gutbier B, Lienau J, Hamelmann E, Opitz B, Suttorp N, Mayer K, Behrens GM, Tschernig T, Witzenrath M.
NOD1 Ligation Suppressed Murine Allergen-Specific T Cell Proliferation and Airway Hyperresponsiveness.
Am J Respir Cell Mol Biol. 2013 Nov 26.
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Bacterial infections and the DNA sensing pathway
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The novel human influenza A(H7N9) virus is naturally adapted to efficient growth in human lung tissue
MBio. 2013 Oct 8;4(5). pii: e00601-13. doi: 10.1128/mBio.00601-13.
Hocke AC, Becher A, Knepper J, Peter A, Holland G, Tönnies M, Bauer TT, Schneider P, Neudecker J, Muth D, Wendtner CM, Rückert JC, Drosten C, Gruber AD, Laue M, Suttorp N, Hippenstiel S, Wolff T.
Emerging Human Middle East Respiratory Syndrome Coronavirus Causes Widespread Infection and Alveolar Damage in Human Lungs.
Am J Respir Crit Care Med. 2013 Oct 1;188(7):882-886.
Hackstein H, Kranz S, Lippitsch A, Wachtendorf A, Kershaw O, Gruber AD, Michel G, Lohmeyer J, Bein G, Baal N, Herold S.
Modulation of respiratory dendritic cells during Klebsiella pneumonia infection.
Resp Res 2013 Sept 17;14(1):91 [Epub ahead of print].
Herold S, Gabrielli NM, Vadasz I.
Novel concepts of acute lung injury and alveolo-capillary barrier dysfunction.
Am J Physiol Lung Cell Mol Physiol. 13 Sept 2013, DOI: 10.1152/ajplung.00232.2013
Bayat B, Tjahjono Y, Sydykov A, Werth S, Hippenstiel S, Weissmann N, Sachs UJ, Santoso S.
Anti-Human Neutrophil Antigen-3a Induced Transfusion-Related Acute Lung Injury in Mice by Direct Disturbance of Lung Endothelial Cells.
Arterioscler Thromb Vasc Biol. 2013 Sep 12. [Epub ahead of print]
Bakr A, Pak O, Taye A, Hamada F, Hemeida R, Janssen W, Gierhardt M, Ghofrani HA, Seeger W, Grimminger F, Schermuly RT, Witzenrath M, Brandes RP, Huang N, Cooke JP, Weissmann N, Sommer N.
Effects of dimethylarginine dimethylaminohydrolase-1 overexpression on the response of the pulmonary vasculature to hypoxia
Am J Respir Cell Mol Biol. 2013 Sep;49(3):491-500
Marsico A, Huska MR, Lasserre J, Hu H, Vucicevic D, Musahl A, Orom UA, Vingron M.
PROmiRNA: a new miRNA promoter recognition method uncovers the complex regulation of intronic miRNAs.
Genome Biol. 2013 Aug 16;14(8)
Lucas R, Czikora I, Sridhar S, Zemskov EA, Oseghale A, Circo S, Cederbaum SD, Chakraborty T, Fulton DJ, Caldwell RW, Romero MJ.
Arginase 1: an unexpected mediator of pulmonary capillary barrier dysfunction in models of acute lung injury.
Front Immunol. 2013, 4:228
Lucas R, Czikora I, Sridhar S, Zemskov E, Gorshkov B, Siddaramappa U, Oseghale A, Lawson J, Verin A, Rick FG, Block NL, Pillich H, Romero M, Leustik M, Schally AV, Chakraborty T.
Mini-review: Novel therapeutic strategies to blunt actions of pneumolysin in the lungs.
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Sittka A, Schmeck B.
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TLR9- and Src-dependent expression of Krueppel-like factor 4 controls interleukin-10 expression in pneumonia.
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Delivery of the endolysin Cpl-1 by inhalation rescues mice with fatal pneumococcal pneumonia.
J Antimicrob Chemother. 2013 Sep;68(9):2111-7. doi: 10.1093/jac/dkt131. Epub 2013 Apr 30.
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Immunotherapy. 2013;5, 365-81.
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Weinheimer VK , Becher A, Tönnies M, Holland G, Knepper J, Bauer TT, Schneider P, Neudecker J, Rückert JC, Szymanski K, Temmesfeld-Wollbrück B, Gruber AD, Bannert N, Suttorp N, Hippenstiel S, Wolff TT, Hocke AC
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Protein Kinase C-a and Arginase I Mediate Pneumolysin-Induced Pulmonary Endothelial Hyperpermeability.
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PlosOne 2011 Mar 31;6(3):e18406
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