Publications
Herbel SM, Moyon L, Christ M, Elsayed EM, Caffrey BE, Malmsheimer S, Grin I, Hoffmann K, Surmann K, Blankenburg S, Jung AL, Herkt CE, Borsò M, Bozdag B, Imhof A, Becker A, Wagner S, Bange G, Völker U, Bertrams W, Marsico A, Schmeck B.
Microbiota-dependent regulation of antimicrobial immunity in the lung
Am J Respir Cell Mol Biol. 2019 Sep;61(3):284-289. doi: 10.1165/rcmb.2019-0101TR.
https://pubmed.ncbi.nlm.nih.gov/31059654/
Fiocca Vernengo F, Opitz B.
TBK1's role in bacterial pneumonia: Perhaps more than macrophages and IFNs
Am J Respir Cell Mol Biol. 2022 Jun;66(6):596-597. doi: 10.1165/rcmb.2022-0040ED.
https://pubmed.ncbi.nlm.nih.gov/35363998/
Herbel SM, Moyon L, Christ M, Elsayed EM, Caffrey BE, Malmsheimer S, Grin I, Hoffmann K, Surmann K, Blankenburg S, Jung AL, Herkt CE, Borsò M, Bozdag B, Imhof A, Becker A, Wagner S, Bange G, Völker U, Bertrams W, Marsico A, Schmeck B.
Screening for eukaryotic motifs in Legionella pneumophila reveals Smh1 as bacterial deacetylase of host histones
Virulence 2022 Dec;13(1):2042-2058.
doi: 10.1080/21505594.2022.2149973. https://pubmed.ncbi.nlm.nih.gov/36411449/
Klatt AB, Diersing C, Lippmann J, Mayer-Lambertz S, Stegmann F, Fischer S, Caesar S, Fiocca Vernengo F, Hönzke K, Hocke AC, Ruland J, Witzenrath M, Lepenies B, Opitz B
CLEC12A binds to Legionella pneumophila but has no impact on the host's antibacterial response
Int J Mol Sci. 2023 Feb 15;24(4):3891. doi: 10.3390/ijms24043891.https://pubmed.ncbi.nlm.nih.gov/36835297/
Erfinanda L, Zou L, Gutbier B, Kneller L, Weidenfeld S, Michalick L, Lei D, Reppe K, Teixeira Alves LG, Schneider B, Zhang Q, Li C, Fatykhova D, Schneider P, Liedtke W, Sohara E, Mitchell TJ, Gruber AD, Hocke A, Hippenstiel S, Suttorp N, Olschewski A, Mall MA, Witzenrath M, Kuebler WM
Loss of endothelial CFTR drives barrier failure and edema formation in lung infection and can be targeted by CFTR potentiation
Sci Transl Med. 2022 Dec 7;14(674):eabg8577.
doi: 10.1126/scitranslmed.abg8577. https://pubmed.ncbi.nlm.nih.gov/36475904/
Hönzke K, Obermayer B, Mache C, Fathykova D, Kessler M, Dökel S, Wyler E, Baumgardt M, Löwa A, Hoffmann K, Graff P, Schulze J, Mieth M, Hellwig K, Demir Z, Biere B, Brunotte L, Mecate-Zambrano A, Bushe J, Dohmen M, Hinze C, Elezkurtaj S, Tönnies M, Bauer TT, Eggeling S, Tran HL, Schneider P, Neudecker J, Rückert JC, Schmidt-Ott KM, Busch J, Klauschen F, Horst D, Radbruch H, Radke J, Heppner F, Corman VM, Niemeyer D, Müller MA, Goffinet C, Mothes R, Pascual-Reguant A, Hauser AE, Beule D, Landthaler M, Ludwig S, Suttorp N, Witzenrath M, Gruber AD, Drosten C, Sander LE, Wolff T, Hippenstiel S, Hocke AC
Human lungs show limited permissiveness for SARS-CoV-2 due to scarce ACE2 levels but virus-induced expansion of inflammatory macrophages
Eur Respir J. 2022 Dec 1;60(6):2102725. doi: 10.1183/13993003.02725-2021.
https://pubmed.ncbi.nlm.nih.gov/35728978/
Bertrams W, Hönzke K, Obermayer B, Tönnies M, Bauer TT, Schneider P, Neudecker J, Rückert JC, Stiewe T, Nist A, Eggeling S, Suttorp N, Wolff T, Hippenstiel S, Schmeck B, Hocke AC
Transcriptomic comparison of primary human lung cells with lung tissue samples and the human A549 lung cell line highlights cell type specific responses during infections with influenza A virus
Sci Rep 12, 2022 Nov 29;12(1):20608.
doi 10.1038/s41598-022-24792-4. https://pubmed.ncbi.nlm.nih.gov/36446841/
Lopez Krol A, Nehring HP, Krause FF, Wempe A, Raifer H, Nist A, Stiewe T, Bertrams W, Schmeck B, Luu M, Leister H, Chung HR, Bauer UM, Adhikary T, Visekruna A.
Lactate induces metabolic and epigenetic reprogramming of pro-inflammatory Th17 cells
EMBO Rep. 2022 Oct 10;e54685. doi: 10.15252/embr.202254685. https://pubmed.ncbi.nlm.nih.gov/36215678/
Aznaourova M, Schmerer N, Janga H, Zhang Z, Pauck K, Bushe J, Volkers SM, Wendisch D, Georg P, Ntini E, Aillaud M, Gündisch M, Mack E, Skevaki C, Keller C, Bauer C, Bertrams W, Marsico A, Nist A, Stiewe T, Gruber AD, Ruppert C, Li Y, Garn H, Sander LE, Schmeck B, Schulte LN.
Single-cell RNA sequencing uncovers the nuclear decoy lincRNA PIRAT as a regulator of systemic monocyte immunity during COVID-19
Proc Natl Acad Sci USA. 2022 Sep 6;119(36):e2120680119. doi: 10.1073/pnas.2120680119. Epub 2022 Aug 23. https://pubmed.ncbi.nlm.nih.gov/35998224/
Kunec D, Osterrieder N, Trimpert J.
Synthetically recoded virus sCPD9 – A tool to accelerate SARS-CoV-2 research under biosafety level 2 conditions
Comput Struct Biotechnol J . 2022;20:4376-4380. doi: 10.1016/j.csbj.2022.08.027. Epub 2022 Aug 13. https://pubmed.ncbi.nlm.nih.gov/35992535/
Hoffmann K, Obermayer B, Hönzke K, Fatykhova D, Demir Z, Löwa A, Alves LGT, Wyler E, Lopez-Rodriguez E, Mieth M, Baumgardt M, Hoppe J, Firsching TC, Tönnies M, Bauer TT, Eggeling S, Tran HL, Schneider P, Neudecker J, Rückert JC, Gruber AD, Ochs M, Landthaler M, Beule D, Suttorp N, Hippenstiel S, Hocke AC, Kessler M.
Human alveolar progenitors generate dual lineage bronchioalveolar organoids
Commun Biol. 2022 Aug 25;5(1):875. doi: 10.1038/s42003-022-03828-5. https://pubmed.ncbi.nlm.nih.gov/36008580/
Hülsemann M, Wiebach J, Drude NI, Kniffert S, Behm L, Hönzke K, Baumgardt M, Hippenstiel S, Hocke AC, Dirnagl U, Tölch U.
Introducing quality measures in an academic research consortium: Lessons and recommendation from implementing an ad hoc quality management system for organ model research
EMBO Rep. 2022 Aug 3;23(8):e55095. doi: 10.15252/embr.202255095. Epub 2022 Jul 25. https://pubmed.ncbi.nlm.nih.gov/35876564/
Pennitz P, Kirsten H, Friedrich VD, Wyler E, Goekeri C, Obermayer B, Heinz GA, Mashreghi MF, Büttner M, Trimpert J, Landthaler M, Suttorp N, Hocke AC, Hippenstiel S, Tönnies M, Scholz M, Kuebler WM, Witzenrath M, Hoenzke K, Nouailles G.
A pulmonologist's guide to perform and analyse cross-species single lung cell transcriptomics
Eur Respir Rev. 2022 Jul 27;31(165):220056. doi: 10.1183/16000617.0056-2022. https://pubmed.ncbi.nlm.nih.gov/35896273/
Schmiedeknecht K, Kaufmann A, Bauer S, Venegas Solis F.
L-lactate as an indicator for cellular metabolic status: An easy and cost-effective colorimetric L-lactate assay
PLoS One. 2022 Jul 22;17(7):e0271818. doi: 10.1371/journal.pone.0271818. https://pubmed.ncbi.nlm.nih.gov/35867690/
Hollenhorst MI, Nandigama R, Evers SB, Gamayun I, Abdel Wadood N, Salah A, Pieper M, Wyatt A, Stukalov A, Gebhardt A, Nadolni W, Burow W, Herr C, Beisswenger C, Kusumakshi S, Ectors F, Kichko TI, Hübner L, Reeh P, Munder A, Wienhold SM, Witzenrath M, Bals R, Flockerzi V, Gudermann T, Bischoff M, Lipp P, Zierler S, Chubanov V, Pichlmair A, König P, Boehm U, Krasteva-Christ G.
Bitter taste signaling in tracheal epithelial brush cells elicits innate immune responses to bacterial infection.
J Clin Invest. 2022; 132(13):e150951. https://pubmed.ncbi.nlm.nih.gov/35503420/
Hönzke K, Obermayer B, Mache C, Fathykova D, Kessler M, Dökel S, Wyler E, Baumgardt M, Löwa A, Hoffmann K, Graff P, Schulze J, Mieth M, Hellwig K, Demir Z, Biere B, Brunotte L, Mecate-Zambrano A, Bushe J, Dohmen M, Hinze C, Elezkurtaj S, Tönnies M, Bauer TT, Eggeling S, Tran HL, Schneider P, Neudecker J, Rückert JC, Schmidt-Ott KM, Busch J, Klauschen F, Horst D, Radbruch H, Radke J, Heppner F, Corman VM, Niemeyer D, Müller MA, Goffinet C, Mothes R, Pascual-Reguant A, Hauser AE, Beule D, Landthaler M, Ludwig S, Suttorp N, Witzenrath M, Gruber AD, Drosten C, Sander LE, Wolff T, Hippenstiel S, Hocke AC.
Human lungs show limited permissiveness for SARS-CoV-2 due to scarce ACE2 levels but virus-induced expansion of inflammatory macrophages
Eur Respir J. 2022 Jun 21;2102725. doi: 10.1183/13993003.02725-2021. https://pubmed.ncbi.nlm.nih.gov/35728978/
Margaroli C, Horati H, Garratt LW, Giacalone VD, Schofield C, Dittrich AS, Rosenow T, Dobosh BS, Lim HS, Frey DL, Veltman M, Silva GL, Brown MR, Schultz C, Tiddens HAWM, Ranganathan S, Chandler JD, Qiu P, Peng L, Scholte BJ, Mall MA, Kicic A, Guglani L, Stick SM, Janssens HM, Tirouvanziam R.
Macrophage PD-1 associates with neutrophilia and reduced bacterial killing in early cystic fibrosis airway disease
J Cyst Fibros. 2022 Jun 19;S1569-1993(22)00588-4. doi: 10.1016/j.jcf.2022.06.001. https://pubmed.ncbi.nlm.nih.gov/35732550/
Tabeling C, González Calera CR, Lienau J, Höppner J, Tschernig T, Kershaw O, Gutbier B, Naujoks J, Herbert J, Opitz B, Gruber AD, Hocher B, Suttorp N, Heidecke H, Burmester GR, Riemekasten G, Siegert E, Kuebler WM, Witzenrath M.
Endothelin B Receptor Immunodynamics in Pulmonary Arterial Hypertension.
Front Immunol. 2022 Jun 9;13:895501. https://pubmed.ncbi.nlm.nih.gov/35757687/
Dannebaum R, Suwalski P, Asgharian H, Du Zhipei G, Lin H, Weiner J, Holtgrewe M, Thibeault C, Müller M, Wang X, Karadeniz Z, Saccomanno J, Doehn JM, Hübner RH, Hinzmann B, Blüher A, Siemann S, Telman D, Suttorp N, Witzenrath M, Hippenstiel S, Skurk C, Poller W, Sander LE, Beule D, Kurth F, Guettouche T, Landmesser U, Berka J, Luong K; Pa-COVID Study Group, Rubelt F, Heidecker B.
Highly multiplexed immune repertoire sequencing links multiple lymphocyte classes with severity of response to COVID-19.
EClinicalMedicine. 2022 Jun;48:101438. https://pubmed.ncbi.nlm.nih.gov/35600330/
Frey DL, Bridson C, Dittrich S, Graeber SY, Stahl M, Wege S, Herth F, Sommerburg O, Schultz C, Dalpke A, Mall MA, Boutin S.
Changes in Microbiome Dominance Are Associated With Declining Lung Function and Fluctuating Inflammation in People With Cystic Fibrosis
Front Microbiol. 2022 May 13;13:885822. doi: 10.3389/fmicb.2022.885822. eCollection 2022. https://pubmed.ncbi.nlm.nih.gov/35633718/
Patrono LV, Vrancken B, Budt M, Düx A, Lequime S, Boral S, Gilbert MTP, Gogarten JF, Hoffmann L, Horst D, Merkel K, Morens D, Prepoint B, Schlotterbeck J, Schuenemann VJ, Suchard MA, Taubenberger JK, Tenkhoff L, Urban C, Widulin N, Winter E, Worobey M, Schnalke T, Wolff T, Lemey P, Calvignac-Spencer S.
Archival influenza virus genomes from Europe reveal genomic variability during the 1918 pandemic
Nat Commun. 2022 May 10;13(1):2314. doi: 10.1038/s41467-022-29614-9. https://pubmed.ncbi.nlm.nih.gov/35538057/
Wyler E, Adler JM, Eschke K, Teixeira Alves G, Peidli S, Pott F, Kazmierski J, Michalick L, Kershaw O, Bushe J, Andreotti S, Pennitz P, Abdelgawad A, Postmus D, Goffinet C, Kreye J, Reincke SM, Prüss H, Blüthgen N, Gruber AD, Kuebler WM, Witzenrath M, Landthaler M, Nouailles G, Trimpert J.
Key benefits of dexamethasone and antibody treatment in COVID-19 hamster models revealed by single-cell transcriptomics
Mol Ther. 2022 May 4;30(5):1952-1965. doi: 10.1016/j.ymthe.2022.03.014. Epub 2022 Mar 24. https://pubmed.ncbi.nlm.nih.gov/35339689/
Lingscheid T, Lippert LJ, Hillus D, Kruis T, Thibeault C, Helbig ET, Tober-Lau P, Pfäfflin F, Müller-Redetzky H, Witzenrath M, Zoller T, Uhrig A, Opitz B, Suttorp N, Kramer TS, Sander LE, Stegemann MS, Kurth F.
Characterization of antimicrobial use and co-infections among hospitalized patients with COVID-19: a prospective observational cohort study.
Infection. 2022 Apr 14:1-12. https://pubmed.ncbi.nlm.nih.gov/35420370/
Westendorp WF, Dames C, Nederkoorn PJ, Meisel A.
Immunodepression, Infections, and Functional Outcome in Ischemic Stroke
Stroke. 2022 Mar 28;STROKEAHA122038867. doi: 10.1161/STROKEAHA.122.038867. https://pubmed.ncbi.nlm.nih.gov/35341322/
Loske J, Röhmel J, Lukassen S, Stricker S, Magalhães VG, Liebig J, Chua RL, Thürmann L, Messingschlager M, Seegebarth A, Timmermann B, Klages S, Ralser M, Sawitzki B, Sander LE, Corman VM, Conrad C, Laudi S, Binder M, Trump S, Eils R, Mall MA, Lehmann I.
Pre-activated antiviral innate immunity in the upper airways controls early SARS-CoV-2 infection in children
Nat Biotechnol. 2022 Mar;40(3):319-324. doi: 10.1038/s41587-021-01037-9. Epub 2021 Aug 18. https://pubmed.ncbi.nlm.nih.gov/34408314/
Zhu L, Duerr J, Zhou-Suckow Z, Wagner W, Weinheimer O, Salomon J, Leitz D, Konietzke P, Yu H, Ackermann M, Stiller W, Kauczor HU, Mall MA, Wielpütz MO.
µCT to quantify muco-obstructive lung disease and effects of neutrophil elastase knockout in mice
Am J Physiol Lung Cell Mol Physiol. 2022 Mar 1;322(3):L401-L411. doi: 10.1152/ajplung.00341.2021. Epub 2022 Jan 26. https://pubmed.ncbi.nlm.nih.gov/35080183/
Sauerhering L, Kuznetsova I, Kupke A, Meier L, Halwe S, Rohde C, Schmidt J, Morty RE, Danov O, Braun A, Vadász I, Becker S, Herold S.
Cyclosporin A Reveals Potent Antiviral Effects in Preclinical Models of SARS-CoV-2 Infection
Am J Respir Crit Care Med. 2022 Feb 15. doi: 10.1164/rccm.202108-1830LE. Online ahead of print. https://pubmed.ncbi.nlm.nih.gov/35167409/
Kaplonek P, Yao L, Reppe K, Voß F, Kohler T, Ebner F, Schäfer A, Blohm U, Priegue P, Bräutigam M, Pereira CL, Parameswarappa SG, Emmadi M, Ménová P, Witzenrath M, Hammerschmidt S, Hartmann S, Sander LE, Seeberger PH.
A semisynthetic glycoconjugate provides expanded cross-serotype protection against Streptococcus pneumoniae
Vaccine. 2022 Feb 11;40(7):1038-1046. doi: 10.1016/j.vaccine.2021.12.068. Epub 2022 Jan 13. pubmed.ncbi.nlm.nih.gov/35033388/
Wygrecka M, Birnhuber A, Seeliger B, Michalick L, Pak O, Schultz AS, Schramm F, Zacharias M, Gorkiewicz G, David S, Welte T, Schmidt JJ, Weissmann N, Schermuly RT, Barreto G, Schaefer L, Markart P, Brack MC, Hippenstiel S, Kurth F, Sander LE, Witzenrath M, Kuebler WM, Kwapiszewska G, Preissner KT.
Altered fibrin clot structure and dysregulated fibrinolysis contribute to thrombosis risk in severe COVID-19
Blood Adv. 2022 Feb 8;6(3):1074-1087. doi: 10.1182/bloodadvances.2021004816. pubmed.ncbi.nlm.nih.gov/34861681/
Conrad C, Yildiz D, Cleary SJ, Margraf A, Cook L, Schlomann U, Panaretou B, Bowser JL, Karmouty-Quintana H, Li J, Berg NK, Martin SC, Aljohmani A, Moussavi-Harami SF, Wang KM, Tian JJ, Magnen M, Valet C, Qiu L, Singer JP, Eltzschig HK; CAPSys Study Group, Bertrams W, Herold S, Suttorp N, Schmeck B, Ball ZT, Zarbock A, Looney MR, Bartsch JW.
ADAM8 signaling drives neutrophil migration and ARDS severity
JCI Insight. 2022 Feb 8;7(3):e149870. doi: 10.1172/jci.insight.149870. https://pubmed.ncbi.nlm.nih.gov/35132956/
Georg P, Astaburuaga-García R, Bonaguro L, Brumhard S, Michalick L, Lippert LJ, Kostevc T, Gäbel C, Schneider M, Streitz M, Demichev V, Gemünd I, Barone M, Tober-Lau P, Helbig ET, Hillus D, Petrov L, Stein J, Dey HP, Paclik D, Iwert C, Mülleder M, Aulakh SK, Djudjaj S, Bülow RD, Mei HE, Schulz AR, Thiel A, Hippenstiel S, Saliba AE, Eils R, Lehmann I, Mall MA, Stricker S, Röhmel J, Corman VM, Beule D, Wyler E, Landthaler M, Obermayer B, von Stillfried S, Boor P, Demir M, Wesselmann H, Suttorp N, Uhrig A, Müller-Redetzky H, Nattermann J, Kuebler WM, Meisel C, Ralser M, Schultze JL, Aschenbrenner AC, Thibeault C, Kurth F, Sander LE, Blüthgen N, Sawitzki B; PA-COVID-19 Study Group.
Complement activation induces excessive T cell cytotoxicity in severe COVID-19
Cell. 2022 Feb 3;185(3):493-512.e25. doi: 10.1016/j.cell.2021.12.040. Epub 2021 Dec 28. pubmed.ncbi.nlm.nih.gov/35032429/
Bahrs C, Kesselmeier M, Kolditz M, Ewig S, Rohde G, Barten-Neiner G, Rupp J, Witzenrath M, Welte T, Pletz MW; CAPNETZ Study Group.
A longitudinal analysis of pneumococcal vaccine serotypes in pneumonia patients in Germany
Eur Respir J. 2022 Feb 3;59(2):2102432. doi: 10.1183/13993003.02432-2021. Print 2022 Feb. https://pubmed.ncbi.nlm.nih.gov/34824055/
Obermann HL, Lederbogen II, Steele J, Dorna J, Sander LE, Engelhardt K, Bakowsky U, Kaufmann A, Bauer S.
RNA-Cholesterol Nanoparticles Function as Potent Immune Activators via TLR7 and TLR8
Front Immunol. 2022 Jan 21;12:658895. doi: 10.3389/fimmu.2021.658895. eCollection 2021. https://pubmed.ncbi.nlm.nih.gov/35126343/
Kühnapfel A, Horn K, Klotz U, Kiehntopf M, Rosolowski M, Loeffler M, Ahnert P, Suttorp N, Witzenrath M, Scholz M.
Genetic Regulation of Cytokine Response in Patients with Acute Community-Acquired Pneumonia.
Genes (Basel). 2022 Jan 6;13(1):111. https://pubmed.ncbi.nlm.nih.gov/35052452/
Wienhold SM, Brack MC, Nouailles G, Krishnamoorthy G, Korf IHE, Seitz C, Wienecke S, Dietert K, Gurtner C, Kershaw O, Gruber AD, Ross A, Ziehr H, Rohde M, Neudecker J, Lienau J, Suttorp N, Hippenstiel S, Hocke AC, Rohde C, Witzenrath M.
Preclinical Assessment of Bacteriophage Therapy against Experimental Acinetobacter baumannii Lung Infection.
Viruses. 2021 Dec 24;14(1):33. https://pubmed.ncbi.nlm.nih.gov/35062236/
Letsiou E, Teixeira Alves LG, Felten M, Mitchell TJ, Müller-Redetzky HC, Dudek SM, Witzenrath M.
Neutrophil-Derived Extracellular Vesicles Activate Platelets after Pneumolysin Exposure.
Cells. 2021;10(12):3581. https://pubmed.ncbi.nlm.nih.gov/34944089/
Wee BA, Alves J, Lindsay DSJ, Klatt AB, Sargison FA, Cameron RL, Pickering A, Gorzynski J, Corander J, Marttinen P, Opitz B, Smith AJ, Fitzgerald JR.
Population analysis of Legionella pneumophila reveals a basis for resistance to complement-mediated killing
Nat Commun. 2021 Dec 9;12(1):7165. doi: 10.1038/s41467-021-27478-z. https://pubmed.ncbi.nlm.nih.gov/34887398/
Metzger MI, Graeber SY, Stahl M, Sommerburg O, Mall MA, Dalpke AH, Boutin S.
A Volatile and Dynamic Longitudinal Microbiome Is Associated With Less Reduction in Lung Function in Adolescents With Cystic Fibrosis
Front Cell Infect Microbiol. 2021 Dec 6;11:763121. doi: 10.3389/fcimb.2021.763121. eCollection 2021. https://pubmed.ncbi.nlm.nih.gov/34938669/
Trimpert J, Adler JM, Eschke K, Abdelgawad A, Firsching TC, Ebert N, Thao TTN, Gruber AD, Thiel V, Osterrieder N, Kunec D.
Live attenuated virus vaccine protects against SARS-CoV-2 variants of concern B.1.1.7 (Alpha) and B.1.351 (Beta).
Sci Adv. 2021 Dec 3;7(49):eabk0172. doi: 10.1126/sciadv.abk0172. Epub 2021 Dec 1. PMID: 34851677; PMCID: PMC8635430. pubmed.ncbi.nlm.nih.gov/34851677/
Gruber AD, Firsching TC, Trimpert J, Dietert K.
Hamster models of COVID-19 pneumonia reviewed: How human can they be?
Vet Pathol. 2021 Dec 2:3009858211057197. doi: 10.1177/03009858211057197. Epub ahead of print. PMID: 34856819. pubmed.ncbi.nlm.nih.gov/34856819/
Steinbeis F, Thibeault C, Doellinger F, Ring RM, Mittermaier M, Ruwwe-Glösenkamp C, Alius F, Knape P, Meyer HJ, Lippert LJ, Helbig ET, Grund D, Temmesfeld-Wollbrück B, Suttorp N, Sander LE, Kurth F, Penzkofer T, Witzenrath M, Zoller T.
Severity of respiratory failure and computed chest tomography in acute COVID-19 correlates with pulmonary function and respiratory symptoms after infection with SARS-CoV-2: An observational longitudinal study over 12 months.
Respir Med. 2021 Dec 1;191:106709. doi: 10.1016/j.rmed.2021.106709. Epub ahead of print. PMID: 34871947; PMCID: PMC8632363. pubmed.ncbi.nlm.nih.gov/34871947/
Wendisch D, Dietrich O, Mari T, von Stillfried S, Ibarra IL, Mittermaier M, Mache C, Chua RL, Knoll R, Timm S, Brumhard S, Krammer T, Zauber H, Hiller AL, Pascual-Reguant A, Mothes R, Bülow RD, Schulze J, Leipold AM, Djudjaj S, Erhard F, Geffers R, Pott F, Kazmierski J, Radke J, Pergantis P, Baßler K, Conrad C, Aschenbrenner AC, Sawitzki B, Landthaler M, Wyler E, Horst D; Deutsche COVID-19 OMICS Initiative (DeCOI), Hippenstiel S, Hocke A, Heppner FL, Uhrig A, Garcia C, Machleidt F, Herold S, Elezkurtaj S, Thibeault C, Witzenrath M, Cochain C, Suttorp N, Drosten C, Goffinet C, Kurth F, Schultze JL, Radbruch H, Ochs M, Eils R, Müller-Redetzky H, Hauser AE, Luecken MD, Theis FJ, Conrad C, Wolff T, Boor P, Selbach M, Saliba AE, Sander LE.
SARS-CoV-2 infection triggers profibrotic macrophage responses and lung fibrosis.
Cell. 2021 Nov 27:S0092-8674(21)01383-0. doi: 10.1016/j.cell.2021.11.033. Epub ahead of print. PMID: 34914922. pubmed.ncbi.nlm.nih.gov/34914922/
Trimpert J, Herwig S, Stein J, Vladimirova D, Adler JM, Abdelgawad A, Firsching TC, Thoma T, Sehouli J, Osterrieder K, Gruber AD, Sawitzki B, Sander LE, Cichon G.
Deciphering the Role of Humoral and Cellular Immune Responses in Different COVID-19 Vaccines-A Comparison of Vaccine Candidate Genes in Roborovski Dwarf Hamsters.
Viruses. 2021 Nov 16;13(11):2290. doi: 10.3390/v13112290. PMID: 34835096; PMCID: PMC8625836. pubmed.ncbi.nlm.nih.gov/34835096/
Al-Karmalawy AA, Soltane R, Abo Elmaaty A, Tantawy MA, Antar SA, Yahya G, Chrouda A, Pashameah RA, Mustafa M, Abu Mraheil M, Mostafa A.
Coronavirus Disease (COVID-19) Control between Drug Repurposing and Vaccination: A Comprehensive Overview
Vaccines (Basel). 2021 Nov 12;9(11):1317. doi: 10.3390/vaccines9111317. https://pubmed.ncbi.nlm.nih.gov/34835248/
Mahmoud W, Perniss A, Poharkar K, Soultanova A, Pfeil U, Hoek A, Bhushan S, Hain T, Gärtner U, Kummer W.
CXCL13 is expressed in a subpopulation of neuroendocrine cells in the murine trachea and lung.
Cell Tissue Res. 2022 Oct;390(1):35-49. doi: 10.1007/s00441-021-03552-2. pubmed.ncbi.nlm.nih.gov/34762185/
Hey J, Paulsen M, Toth R, Weichenhan D, Butz S, Schatterny J, Liebers R, Lutsik P, Plass C, Mall MA.
Epigenetic reprogramming of airway macrophages promotes polarization and inflammation in muco-obstructive lung disease
Nat Commun. 2021 Nov 11;12(1):6520. doi: 10.1038/s41467-021-26777-9. pubmed.ncbi.nlm.nih.gov/34764283/
Mösbauer K, Fritsch VN, Adrian L, Bernhardt J, Gruhlke MCH, Slusarenko AJ, Niemeyer D, Antelmann H.
The Effect of Allicin on the Proteome of SARS-CoV-2 Infected Calu-3 Cells.
Front Microbiol. 2021 Oct 28;12:746795. doi: 10.3389/fmicb.2021.746795. PMID: 34777295; PMCID: PMC8581659. pubmed.ncbi.nlm.nih.gov/34777295/
Witkowski M, Tizian C, Ferreira-Gomes M, Niemeyer D, Jones TC, Heinrich F, Frischbutter S, Angermair S, Hohnstein T, Mattiola I, Nawrath P, Mc Ewen S, Zocche S, Viviano E, Heinz GA, Maurer M, Kölsch U, Chua RL, Aschman T, Meisel C, Radke J, Sawitzki B, Roehmel J, Allers K, Moos V, Schneider T, Hanitsch L, Mall MA, Conrad C, Radbruch H, Duerr CU, Trapani JA, Marcenaro E, Kallinich T, Corman VM, Kurth F, Sander LE, Drosten C, Treskatsch S, Durek P, Kruglov A, Radbruch A, Mashreghi MF, Diefenbach A.
Untimely TGFβ responses in COVID-19 limit antiviral functions of NK cells
Nature. 2021 Oct 25. doi: 10.1038/s41586-021-04142-6. Epub ahead of print. PMID: 34695836. pubmed.ncbi.nlm.nih.gov/34695836/
Van Loi V, Busche T, Fritsch VN, Weise C, Gruhlke MCH, Slusarenko AJ, Kalinowski J, Antelmann H.
The two-Cys-type TetR repressor GbaA confers resistance under disulfide and electrophile stress in Staphylococcus aureus.
Free Radic Biol Med. 2021 Oct 19;177:120-131. doi: 10.1016/j.freeradbiomed.2021.10.024. Epub ahead of print. PMID: 34678418. pubmed.ncbi.nlm.nih.gov/34678418/
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Analysis of SARS-CoV-2 replication in explant cultures of the human upper respiratory tract reveals broad tissue tropism of wild-type and B.1.1.7 variant viruses.
J Infect Dis. 2021 Oct 15:jiab523. doi: 10.1093/infdis/jiab523. Epub ahead of print. PMID: 34651643; PMCID: PMC8524635. pubmed.ncbi.nlm.nih.gov/34651643/
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Sex-specific differences in plasma levels of FXII, HK, and FXIIa-C1-esterase inhibitor complexes in community-acquired pneumonia.
Am J Physiol Lung Cell Mol Physiol. 2021 Oct 1;321(4):L764-L774. doi: 10.1152/ajplung.00162.2021. Epub 2021 Jul 28. PMID: 34318685. pubmed.ncbi.nlm.nih.gov/34318685/
Brox R, Achenbach S, Hackstein H.
Detection of SARS-CoV-2-independent immunoregulatory activity of COVID-19 convalescent plasma.
Transfusion. 2021 Sep 21. doi: 10.1111/trf.16685. Epub ahead of print. PMID: 34546583. pubmed.ncbi.nlm.nih.gov/34546583/
Shaban MS, Müller C, Mayr-Buro C, Weiser H, Meier-Soelch J, Albert BV, Weber A, Linne U, Hain T, Babayev I, Karl N, Hofmann N, Becker S, Herold S, Schmitz ML, Ziebuhr J, Kracht M.
Multi-level inhibition of coronavirus replication by chemical ER stress.
Nat Commun. 2021 Sep 20;12(1):5536. doi: 10.1038/s41467-021-25551-1. PMID: 34545074; PMCID: PMC8452654. pubmed.ncbi.nlm.nih.gov/34545074/
Mermer P, Strotmann J, Kummer W, Paddenberg R.
Olfactory receptor Olfr78 (prostate-specific G protein-coupled receptor PSGR) expression in arterioles supplying skeletal and cardiac muscles and in arterioles feeding some murine organs
Histochem Cell Biol. 2021 Dec;156(6):539-553. doi: 10.1007/s00418-021-02032-6. Epub 2021 Sep 20. https://pubmed.ncbi.nlm.nih.gov/34545457/
Pusch L, Brox R, Scheuer K, Yokosawa T, Wu M, Zubiri BA, Spiecker E, Jandt KD, Fischer D, Hackstein H.
Distinct endocytosis and immune activation of poly(lactic-co-glycolic) acid nanoparticles prepared by single- and double-emulsion evaporation.
Nanomedicine (Lond). 2021 Oct;16(23):2075-2094. doi: 10.2217/nnm-2021-0022. Epub 2021 Sep 15. PMID: 34523349. pubmed.ncbi.nlm.nih.gov/34523349/
Lee S, Yu Y, Trimpert J, Benthani F, Mairhofer M, Richter-Pechanska P, Wyler E, Belenki D, Kaltenbrunner S, Pammer M, Kausche L, Firsching TC, Dietert K, Schotsaert M, Martínez-Romero C, Singh G, Kunz S, Niemeyer D, Ghanem R, Salzer HJF, Paar C, Mülleder M, Uccellini M, Michaelis EG, Khan A, Lau A, Schönlein M, Habringer A, Tomasits J, Adler JM, Kimeswenger S, Gruber AD, Hoetzenecker W, Steinkellner H, Purfürst B, Motz R, Di Pierro F, Lamprecht B, Osterrieder N, Landthaler M, Drosten C, García-Sastre A, Langer R, Ralser M, Eils R, Reimann M, Fan DNY, Schmitt CA.
Virus-induced senescence is a driver and therapeutic target in COVID-19.
Nature. 2021 Nov;599(7884):283-289. doi: 10.1038/s41586-021-03995-1. Epub 2021 Sep 13. PMID: 34517409. pubmed.ncbi.nlm.nih.gov/34517409/
Herta T, Bhattacharyya A, Rosolowski M, Conrad C, Gurtner C, Gruber AD, Ahnert P, Gutbier B, Frey D, Suttorp N, Hippenstiel S, Zahlten J.
Krueppel-Like Factor 4 Expression in Phagocytes Regulates Early Inflammatory Response and Disease Severity in Pneumococcal Pneumonia.
Front Immunol. 2021 Sep 13;12:726135. doi: 10.3389/fimmu.2021.726135. PMID: 34589087; PMCID: PMC8473698. pubmed.ncbi.nlm.nih.gov/34589087/
Lee S, Yu Y, Trimpert J, Benthani F, Mairhofer M, Richter-Pechanska P, Wyler E, Belenki D, Kaltenbrunner S, Pammer M, Kausche L, Firsching TC, Dietert K, Schotsaert M, Martínez-Romero C, Singh G, Kunz S, Niemeyer D, Ghanem R, Salzer HJF, Paar C, Mülleder M, Uccellini M, Michaelis EG, Khan A, Lau A, Schönlein M, Habringer A, Tomasits J, Adler JM, Kimeswenger S, Gruber AD, Hoetzenecker W, Steinkellner H, Purfürst B, Motz R, Di Pierro F, Lamprecht B, Osterrieder N, Landthaler M, Drosten C, García-Sastre A, Langer R, Ralser M, Eils R, Reimann M, Fan DNY, Schmitt CA.
Virus-induced senescence is driver and therapeutic target in COVID-19.
Nature. 2021 Sep 13. doi: 10.1038/s41586-021-03995-1. Epub ahead of print. PMID: 34517409. pubmed.ncbi.nlm.nih.gov/34517409/
Schroeder S, Mache C, Kleine-Weber H, Corman VM, Muth D, Richter A, Fatykhova D, Memish ZA, Stanifer ML, Boulant S, Gultom M, Dijkman R, Eggeling S, Hocke A, Hippenstiel S, Thiel V, Pöhlmann S, Wolff T, Müller MA, Drosten C.
Functional comparison of MERS-coronavirus lineages reveals increased replicative fitness of the recombinant lineage 5.
Nat Commun. 2021 Sep 7;12(1):5324. doi: 10.1038/s41467-021-25519-1. PMID: 34493730. pubmed.ncbi.nlm.nih.gov/34493730/
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Increased risk of severe clinical course of COVID-19 in carriers of HLA-C*04:01
EClinicalMedicine. 2021 Oct;40:101099. doi: 10.1016/j.eclinm.2021.101099. Epub 2021 Sep 2. PMID: 34490415; PMCID: PMC8410317. pubmed.ncbi.nlm.nih.gov/34490415/
Loyal L, Braun J, Henze L, Kruse B, Dingeldey M, Reimer U, Kern F, Schwarz T, Mangold M, Unger C, Dörfler F, Kadler S, Rosowski J, Gürcan K, Uyar-Aydin Z, Frentsch M, Kurth F, Schnatbaum K, Eckey M, Hippenstiel S, Hocke A, Müller MA, Sawitzki B, Miltenyi S, Paul F, Mall MA, Wenschuh H, Voigt S, Drosten C, Lauster R, Lachman N, Sander LE, Corman VM, Röhmel J, Meyer-Arndt L, Thiel A, Giesecke-Thiel C.
Cross-reactive CD4+ T cells enhance SARS-CoV-2 immune responses upon infection and vaccination.
Science. 2021 Aug 31:eabh1823. doi: 10.1126/science.abh1823. Epub ahead of print. PMID: 34465633. pubmed.ncbi.nlm.nih.gov/34465633/
Linzner N, Antelmann H.
The Antimicrobial Activity of the AGXX® Surface Coating Requires a Small Particle Size to Efficiently Kill Staphylococcus aureus.
Front Microbiol. 2021 Aug 12;12:731564. doi: 10.3389/fmicb.2021.731564. PMID: 34456898; PMCID: PMC8387631. pubmed.ncbi.nlm.nih.gov/34456898/
Hillus D, Schwarz T, Tober-Lau P, Vanshylla K, Hastor H, Thibeault C, Jentzsch S, Helbig ET, Lippert LJ, Tscheak P, Schmidt ML, Riege J, Solarek A, von Kalle C, Dang-Heine C, Gruell H, Kopankiewicz P, Suttorp N, Drosten C, Bias H, Seybold J; EICOV/COVIM Study Group, Klein F, Kurth F, Corman VM, Sander LE.
Safety, reactogenicity, and immunogenicity of homologous and heterologous prime-boost immunisation with ChAdOx1 nCoV-19 and BNT162b2: a prospective cohort study.
Lancet Respir Med. 2021 Aug 12:S2213-2600(21)00357-X. doi: 10.1016/S2213-2600(21)00357-X. Epub ahead of print. PMID: 34391547; PMCID: PMC8360702. pubmed.ncbi.nlm.nih.gov/34391547/
Nouailles G, Wyler E, Pennitz P, Postmus D, Vladimirova D, Kazmierski J, Pott F, Dietert K, Muelleder M, Farztdinov V, Obermayer B, Wienhold SM, Andreotti S, Hoefler T, Sawitzki B, Drosten C, Sander LE, Suttorp N, Ralser M, Beule D, Gruber AD, Goffinet C, Landthaler M, Trimpert J, Witzenrath M.
Temporal omics analysis in Syrian hamsters unravel cellular effector responses to moderate COVID-19
Nat Commun. 2021 Aug 11;12(1):4869. doi: 10.1038/s41467-021-25030-7. https://pubmed.ncbi.nlm.nih.gov/34381043/
Trimpert J, Dietert K, Firsching TC, Ebert N, Thi Nhu Thao T, Vladimirova D, Kaufer S, Labroussaa F, Abdelgawad A, Conradie A, Höfler T, Adler JM, Bertzbach LD, Jores J, Gruber AD, Thiel V, Osterrieder N, Kunec D.
Development of safe and highly protective live-attenuated SARS-CoV-2 vaccine candidates by genome recoding
Cell Rep. 2021 Aug 3;36(5):109493. doi: 10.1016/j.celrep.2021.109493. Epub 2021 Jul 20. https://pubmed.ncbi.nlm.nih.gov/34320400/
Paulina Kaplonek, Ling Yao, Katrin Reppe, Franziska Voß, Thomas Kohler, Friederike Ebner, Alexander Schäfer, Ulrike Blohm, Patricia Priegue, Maria Bräutigam, Claney L. Pereira, Sharavathi G. Parameswarappa, Madhu Emmadi, Petra Ménová, Martin Witzenrath, Sven Hammerschmidt, Susanne Hartmann, Leif E. Sander, Peter H. Seeberger
A semisynthetic glycoconjugate provides expanded cross-serotype protection against Streptococcus pneumoniae .
bioRxiv 2021.07.29.454378; doi: doi.org/10.1101/2021.07.29.454378www.biorxiv.org/content/10.1101/2021.07.29.454378v1
Engelmann TA, Knudsen L, Leitz DHW, Duerr J, Beers MF, Mall MA, Ochs M.
Linking Fibrotic Remodeling and Ultrastructural Alterations of Alveolar Epithelial Cells after Deletion of Nedd4-2.
Int J Mol Sci. 2021 Jul 16;22(14):7607. doi: 10.3390/ijms22147607. PMID: 34299227; PMCID: PMC8306112. pubmed.ncbi.nlm.nih.gov/34299227/
Gadalla MR, Morrison E, Serebryakova MV, Han X, Wolff T, Freund C, Kordyukova L, Veit M.
NS1-mediated upregulation of ZDHHC22 acyltransferase in influenza a virus infected cells
Cell Microbiol. 2021 Jun;23(6):e13322. doi: 10.1111/cmi.13322. Epub 2021 Mar 9. https://pubmed.ncbi.nlm.nih.gov/33629465/
Gassen NC, Papies J, Bajaj T, Emanuel J, Dethloff F, Chua RL, Trimpert J, Heinemann N, Niemeyer C, Weege F, Hönzke K, Aschman T, Heinz DE, Weckmann K, Ebert T, Zellner A, Lennarz M, Wyler E, Schroeder S, Richter A, Niemeyer D, Hoffmann K, Meyer TF, Heppner FL, Corman VM, Landthaler M, Hocke AC, Morkel M, Osterrieder N, Conrad C, Eils R, Radbruch H, Giavalisco P, Drosten C, Müller MA.
SARS-CoV-2-mediated dysregulation of metabolism and autophagy uncovers host-targeting antivirals.
Nat Commun. 2021 Jun 21;12(1):3818. doi: 10.1038/s41467-021-24007-w. PMID: 34155207; PMCID: PMC8217552. pubmed.ncbi.nlm.nih.gov/34155207/
Jagdmann S, Berchtold D, Gutbier B, Witzenrath M, Meisel A, Meisel C, Dames C
Efficacy and safety of intratracheal IFN-γ treatment to reverse stroke-induced susceptibility to pulmonary bacterial infections
J Neuroimmunol. 2021 Jun 15;355:577568. doi: 10.1016/j.jneuroim.2021.577568. Epub 2021 Apr 3. PMID: 33862420. pubmed.ncbi.nlm.nih.gov/33862420/
Demichev V, Tober-Lau P, Lemke O, Nazarenko T, Thibeault C, Whitwell H, Röhl A, Freiwald A, Szyrwiel L, Ludwig D, Correia-Melo C, Aulakh SK, Helbig ET, Stubbemann P, Lippert LJ, Grüning NM, Blyuss O, Vernardis S, White M, Messner CB, Joannidis M, Sonnweber T, Klein SJ, Pizzini A, Wohlfarter Y, Sahanic S, Hilbe R, Schaefer B, Wagner S, Mittermaier M, Machleidt F, Garcia C, Ruwwe-Glösenkamp C, Lingscheid T, Bosquillon de Jarcy L, Stegemann MS, Pfeiffer M, Jürgens L, Denker S, Zickler D, Enghard P, Zelezniak A, Campbell A, Hayward C, Porteous DJ, Marioni RE, Uhrig A, Müller-Redetzky H, Zoller H, Löffler-Ragg J, Keller MA, Tancevski I, Timms JF, Zaikin A, Hippenstiel S, Ramharter M, Witzenrath M, Suttorp N, Lilley K, Mülleder M, Sander LE; PA-COVID-19 Study group, Ralser M, Kurth F.
A time-resolved proteomic and prognostic map of COVID-19
Cell Syst. 2021 Jun 14:S2405-4712(21)00160-5. doi: 10.1016/j.cels.2021.05.005. Epub ahead of print. PMID: 34139154; PMCID: PMC8201874. pubmed.ncbi.nlm.nih.gov/34139154/
Leitz DHW, Duerr J, Mulugeta S, Seyhan Agircan A, Zimmermann S, Kawabe H, Dalpke AH, Beers MF, Mall MA.
Congenital Deletion of Nedd4-2 in Lung Epithelial Cells Causes Progressive Alveolitis and Pulmonary Fibrosis in Neonatal Mice.
Int J Mol Sci. 2021 Jun 7;22(11):6146. doi: 10.3390/ijms22116146. PMID: 34200296; PMCID: PMC8201155. pubmed.ncbi.nlm.nih.gov/34200296/
Hagner M, Albrecht M, Guerra M, Braubach P, Halle O, Zhou-Suckow Z, Butz S, Jonigk D, Hansen G, Schultz C, Dittrich AM, Mall MA.
IL-17A from innate and adaptive lymphocytes contributes to inflammation and damage in cystic fibrosis lung disease
Eur Respir J. 2021 Jun 4;57(6):1900716. doi: 10.1183/13993003.00716-2019. PMID: 33303549. pubmed.ncbi.nlm.nih.gov/33303549/
Witzenrath M, Kuebler WM.
The CypA-netics of Ventilator-Induced Lung Injury
Am J Respir Crit Care Med. 2021 May 25. doi: 10.1164/rccm.202104-0919ED. Epub ahead of print. PMID: 34033522. pubmed.ncbi.nlm.nih.gov/34033522/
Jung AL, Schmeck B, Wiegand M, Bedenbender K, Benedikter BJ.
The clinical role of host and bacterial-derived extracellular vesicles in pneumonia
Adv Drug Deliv Rev. 2021 May 19:S0169-409X(21)00185-X. doi: 10.1016/j.addr.2021.05.021. Epub ahead of print. PMID: 34022269. pubmed.ncbi.nlm.nih.gov/34022269/
Schmerer N, Schulte LN.
Long noncoding RNAs in bacterial infection
Wiley Interdiscip Rev RNA. 2021 May 14:e1664. doi: 10.1002/wrna.1664. Epub ahead of print. PMID: 33989449. pubmed.ncbi.nlm.nih.gov/33989449/
Birnhuber A, Fliesser E, Gorkiewicz G, Zacharias M, Seeliger B, David S, Welte T, Schmidt J, Olschewski H, Wygrecka M, Kwapiszewska G.
Between inflammation and thrombosis - endothelial cells in COVID-19
Eur Respir J. 2021 May 13:2100377. doi: 10.1183/13993003.00377-2021. Epub ahead of print. PMID: 33958433; PMCID: PMC8112008. pubmed.ncbi.nlm.nih.gov/33958433/
McKelvey MC, Brown R, Ryan S, Mall MA, Weldon S, Taggart CC.
Proteases, Mucus, and Mucosal Immunity in Chronic Lung Disease
Int J Mol Sci. 2021 May 9;22(9):5018. doi: 10.3390/ijms22095018. PMID: 34065111; PMCID: PMC8125985. pubmed.ncbi.nlm.nih.gov/34065111/
Letsiou E, Teixeira Alves LG, Fatykhova D, Felten M, Mitchell TJ, Müller-Redetzky HC, Hocke AC, Witzenrath M.
Microvesicles released from pneumolysin-stimulated lung epithelial cells carry mitochondrial cargo and suppress neutrophil oxidative burst
Sci Rep. 2021 May 5;11(1):9529. doi: 10.1038/s41598-021-88897-y. PMID: 33953279; PMCID: PMC8100145. pubmed.ncbi.nlm.nih.gov/33953279/
Hadzibegovic S, Lena A, Churchill TW, Ho JE, Potthoff S, Denecke C, Rösnick L, Heim KM, Kleinschmidt M, Sander LE, Witzenrath M, Suttorp N, Krannich A, Porthun J, Friede T, Butler J, Wilkenshoff U, Pieske B, Landmesser U, Anker SD, Lewis GD, Tschöpe C, Anker MS.
Heart failure with preserved ejection fraction according to the HFA-PEFF score in COVID-19 patients: clinical correlates and echocardiographic findings
Eur J Heart Fail. 2021 May 1:10.1002/ejhf.2210. doi: 10.1002/ejhf.2210. Epub ahead of print. PMID: 33932255; PMCID: PMC8239668. pubmed.ncbi.nlm.nih.gov/33932255/
Bertrams W, Lindhauer NS, Rieke MC, Paas A, Hoffmann K, Greene B, Visekruna A, Vilcinskas A, Seidel K, Schmeck B.
Tribolium castaneum defensin 1 kills Moraxella catarrhalis in an in vitro infection model but does not harm commensal bacteria
Virulence. 2021 Dec;12(1):1003-1010. doi: 10.1080/21505594.2021.1908741. PMID: 33843461; PMCID: PMC8043168. pubmed.ncbi.nlm.nih.gov/33843461/
Messner CB, Demichev V, Bloomfield N, Yu JSL, White M, Kreidl M, Egger AS, Freiwald A, Ivosev G, Wasim F, Zelezniak A, Jürgens L, Suttorp N, Sander LE, Kurth F, Lilley KS, Mülleder M, Tate S, Ralser M.
Ultra-fast proteomics with Scanning SWATH.
Nat Biotechnol. 2021 Mar 25. doi: 10.1038/s41587-021-00860-4. Online ahead of print. PMID: 33767396. pubmed.ncbi.nlm.nih.gov/33767396/
Doehn JM, Tabeling C, Biesen R, Saccomanno J, Madlung E, Pappe E, Gabriel F, Kurth F, Meisel C, Corman VM, Hanitsch LG, Treskatsch S, Heim K, Stegemann MS, Ruwwe-Glösenkamp C, Müller-Redetzky HC, Uhrig A, Somasundaram R, Spies C, von Bernuth H, Hofmann J, Drosten C, Suttorp N, Witzenrath M, Sander LE, Hübner RH.
CD169/SIGLEC1 is expressed on circulating monocytes in COVID-19 and expression levels are associated with disease severity
Infection. 2021 Apr 6:1–6. doi: 10.1007/s15010-021-01606-9. Epub ahead of print. PMID: 33825125; PMCID: PMC8023546. pubmed.ncbi.nlm.nih.gov/33825125/
Bertrams W, Griss K, Han M, Seidel K, Hippenstiel S, Suttorp N, Finkernagel F, Wilhelm J, Vogelmeier CF, Schmeck B.
Transcriptional analysis identifies potential biomarkers and molecular regulators in acute malaria infection
Life Sci. 2021 Apr 1;270:119158. doi: 10.1016/j.lfs.2021.119158. Epub 2021 Feb 2. PMID: 33545200. pubmed.ncbi.nlm.nih.gov/33545200/
Cunningham S, Hackstein H.
Rapid generation of monocyte-derived antigen-presenting cells with dendritic cell-like properties.
Transfusion. 2021 Jun;61(6):1845-1855. doi: 10.1111/trf.16385. Epub 2021 Mar 30. PMID: 33786883. pubmed.ncbi.nlm.nih.gov/33786883/
Adhikary PP, Ul Ain Q, Hocke AC, Hedtrich S.
COVID-19 highlights the model dilemma in biomedical research
Nat Rev Mater. 2021 Mar 17:1-3. doi: 10.1038/s41578-021-00305-z. Epub ahead of print. PMID: 33747552; PMCID: PMC7967778. pubmed.ncbi.nlm.nih.gov/33747552/
Perniss A, Schmidt P, Soultanova A, Papadakis T, Dahlke K, Voigt A, Schütz B, Kummer W, Deckmann K.
Development of epithelial cholinergic chemosensory cells of the urethra and trachea of mice
Cell Tissue Res. 2021 Feb 22. doi: 10.1007/s00441-021-03424-9. Epub ahead of print. PMID: 33616728. pubmed.ncbi.nlm.nih.gov/33616728/
Brown R, Small DM, Doherty DF, Holsinger L, Booth R, Williams R, Ingram RJ, Elborn JS, Mall MA, Taggart CC, Weldon S.
Therapeutic Inhibition of Cathepsin S Reduces Inflammation and Mucus Plugging in Adult βENaC-Tg Mice.
Mediators Inflamm. 2021 Mar 19;2021:6682657. doi: 10.1155/2021/6682657. PMID: 33828414; PMCID: PMC8004367.
Leister H, Luu M, Staudenraus D, Lopez Krol A, Mollenkopf H, Sharma A, Schmerer N, Schulte LN, Bertrams W, Schmeck B, Bosmann M, Steinhoff U, Visekruna A.
Pro- and anti-tumorigenic capacity of immunoproteasomes in shaping the tumor microenvironment
Cancer Immunol Res. 2021 Mar 11. doi: 10.1158/2326-6066.CIR-20-0492. Epub ahead of print. PMID: 33707310. pubmed.ncbi.nlm.nih.gov/33707310/
Vazquez-Armendariz AI, Herold S.
From Clones to Buds and Branches. The Use of Lung Organoids to Mod Branching Morphogenesis Ex Vivo
Front Cell Dev Biol. 2021 Mar 4;9:631579. doi: 10.3389/fcell.2021.631579. PMID: 33748115; PMCID: PMC7969706. pubmed.ncbi.nlm.nih.gov/33748115/
Tabeling C, Wienhold SM, Birnhuber A, Brack MC, Nouailles G, Kershaw O, Firsching TC, Gruber AD, Lienau J, Marsh LM, Olschewski A, Kwapiszewska G, Witzenrath M.
Pulmonary fibrosis in Fra-2 transgenic mice is associated with decreased numbers of alveolar macrophages and increased susceptibility to pneumococcal pneumonia
Am J Physiol Lung Cell Mol Physiol. 2021 Mar 3. doi: 10.1152/ajplung.00505.2020. Epub ahead of print. PMID: 33655757. pubmed.ncbi.nlm.nih.gov/33655757/
Gonzales J, Chakraborty T, Romero M, Mraheil MA, Kutlar A, Pace B, Lucas R.
Streptococcus pneumoniae and Its Virulence Factors H2O2 and Pneumolysin Are Potent Mediators of the Acute Chest Syndrome in Sickle Cell Disease
Toxins (Basel). 2021 Feb 17;13(2):157. doi: 10.3390/toxins13020157. https://pubmed.ncbi.nlm.nih.gov/33671422/
Linden G, Janga H, Franz M, Nist A, Stiewe T, Schmeck B, Vázquez O, Schulte LN.
Efficient antisense inhibition reveals microRNA-155 to restrain a late-myeloid inflammatory programme in primary human phagocytes
RNA Biol. 2021 Feb 23:1-15. doi: 10.1080/15476286.2021.1885209. Epub ahead of print. PMID: 33622174. pubmed.ncbi.nlm.nih.gov/33622174/
Bhattacharyya A, Herta T, Conrad C, Frey D, García P, Suttorp N, Hippenstiel S, Zahlten J.
Induction of Krüppel-Like Factor 4 Mediates Polymorphonuclear Neutrophil Activation in Streptococcus pneumoniae Infection.
Front Microbiol. 2021 Feb 3;11:582070. doi: 10.3389/fmicb.2020.582070. PMID: 33613460; PMCID: PMC7887292. pubmed.ncbi.nlm.nih.gov/33613460/
Ochs M, Timm S, Elezkurtaj S, Horst D, Meinhardt J, Heppner FL, Weber-Carstens S, Hocke AC, Witzenrath M.
Collapse induration of alveoli is an ultrastructural finding in a COVID-19 patient
Eur Respir J. 2021 Jan 14:2004165. doi: 10.1183/13993003.04165-2020. Epub ahead of print. PMID: 33446606; PMCID: PMC7815985. pubmed.ncbi.nlm.nih.gov/33446606/
Thibeault C, Suttorp N, Opitz B
The microbiota in pneumonia: from protection to predisposition.
Sci Transl Med. 2021 Jan 13;13(576):eaba0501. doi: 10.1126/scitranslmed.aba0501. PMID: 33441423. pubmed.ncbi.nlm.nih.gov/33441423/
Frey DL, Boutin S, Dittrich SA, Graeber SY, Stahl M, Wege S, Herth FJF, Sommerburg O, Schultz C, Mall MA, Dalpke AH.
Relationship between airway dysbiosis, inflammation and lung function in adults with cystic fibrosis
J Cyst Fibros. 2021 Jan 8:S1569-1993(20)30954-1. doi: 10.1016/j.jcf.2020.12.022. Epub ahead of print. PMID: 33431308. pubmed.ncbi.nlm.nih.gov/33431308/
Weitbrecht L, Berchtold D, Zhang T, Jagdmann S, Dames C, Winek K, Meisel C, Meisel A.
CD4 + T cells promote delayed B cell responses in the ischemic brain after experimental stroke
Brain Behav Immun. 2021 Jan;91:601-614. doi: 10.1016/j.bbi.2020.09.029. Epub 2020 Sep 28. https://pubmed.ncbi.nlm.nih.gov/33002634/
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Transfer RNA fragments replace microRNA regulators of the cholinergic poststroke immune blockade
Proc Natl Acad Sci U S A. 2020 Dec 22;117(51):32606-32616. doi: 10.1073/pnas.2013542117. Epub 2020 Dec 7. https://pubmed.ncbi.nlm.nih.gov/33288717/
Vlaar APJ, de Bruin S, Busch M, Timmermans SAMEG, van Zeggeren IE, Koning R, Ter Horst L, Bulle EB, van Baarle FEHP, van de Poll MCG, Kemper EM, van der Horst ICC, Schultz MJ, Horn J, Paulus F, Bos LD, Wiersinga WJ, Witzenrath M, Rueckinger S, Pilz K, Brouwer MC, Guo RF, Heunks L, van Paassen P, Riedemann NC, van de Beek D.
Anti-C5a antibody IFX-1 (vilobelimab) treatment versus best supportive care for patients with severe COVID-19 (PANAMO): an exploratory, open-label, phase 2 randomised controlled trial
Lancet Rheumato. 2020 Dec;2(12):e764-e773. doi: 10.1016/S2665-9913(20)30341-6.
Trimpert J, Vladimirova D, Dietert K, Abdelgawad A, Kunec D, Dökel S, Voss A, Gruber AD, Bertzbach LD, Osterrieder N.
The Roborovski Dwarf Hamster Is A Highly Susceptible Model for a Rapid and Fatal Course of SARS-CoV-2 Infection
Cell Rep. 2020 Dec 8;33(10):108488. doi: 10.1016/j.celrep.2020.108488
Schirm S, Ahnert P, Berger S, Nouailles G, Wienhold SM, Müller-Redetzky H, Suttorp N, Loeffler M, Witzenrath M, Scholz M.
A biomathematical model of immune response and barrier function in mice with pneumococcal lung infection
PLoS One. 2020 Dec 3;15(12):e0243147. doi: 10.1371/journal.pone.0243147.
Gruber AD, Osterrieder N, Bertzbach LD, Vladimirova D, Greuel S, Ihlow J, Horst D, Trimpert J, and Dietert K.
Standardization of Reporting Criteria for Lung Pathology in SARS-CoV-2-infected Hamsters: What Matters?
Linzner N, Loi VV, Fritsch VN, Antelmann H.
Thiol-based redox switches in the major pathogen Staphylococcus aureus.
Fritsch VN, Loi VV, Busche T, Tung QN, Lill R, Horvatek P, Wolz C, Kalinowski J, Antelmann H.
The alarmone (p)ppGpp confers tolerance to oxidative stress during the stationary phase by maintenance of redox and iron homeostasis in Staphylococcus aureus.
Free Radic Biol Med. 2020 Dec;161:351-364. doi: 10.1016/j.freeradbiomed.2020.10.322.
Aznaourova M, Schmerer N, Schmeck B, Schulte LN.
Disease-Causing Mutations and Rearrangements in Long Non-coding RNA Gene Loci
Front Genet. 2020 Nov 30;11:527484. doi: 10.3389/fgene.2020.527484. PMID: 33329688; PMCID: PMC7735109.
Mittermaier M, Pickerodt P, Kurth F, de Jarcy LB, Uhrig A, Garcia C, Machleidt F, Pergantis P, Weber S, Li Y, Breitbart A, Bremer F, Knape P, Dewey M, Doellinger F, Weber-Carstens S, Slutsky AS, Kuebler WM, Suttorp N, Müller-Redetzky H.
Evaluation of PEEP and prone positioning in early COVID-19 ARDS
EClinicalMedicine. 2020 Nov;28:100579. doi: 10.1016/j.eclinm.2020.100579. Epub 2020 Oct 11. PMID: 33073217; PMCID: PMC7547915. pubmed.ncbi.nlm.nih.gov/33073217/
Walther K, Schulte LN.
The role of lncRNAs in innate immunity and inflammation
RNA Biol. 2020 Nov 19:1-17. doi: 10.1080/15476286.2020.1845505. Epub ahead of print. PMID: 33138685.
Michalick L, Weidenfeld S, Grimmer B, Fatykhova D, Solymosi PD, Behrens F, Dohmen M, Brack MC, Schulz S, Thomasch E, Simmons S, Müller-Redetzky H, Suttorp N, Kurth F, Neudecker J, Toennies M, Bauer TT, Eggeling S, Corman VM, Hocke AC, Witzenrath M, Hippenstiel S, Kuebler WM.
Plasma mediators in patients with severe COVID-19 cause lung endothelial barrier failure
Eur Respir J. 2020 Nov 5;2002384. doi: 10.1183/13993003.02384-2020. Online ahead of print.
Vázquez-Armendariz AI, Heiner M, El Agha E, Salwig I, Hoek A, Rupp MC, Shalashova I, Shrestha A, Carraro G, Mengel JP, Günther A, Morty RE, Vadasz I, Schwemmle M, Kummer W, Hain T, Goesmann A, Bellusci S, Seeger W, Braun T, Herold S.
Multilineage murine stem cells generate complex organoids to model distal lung development and disease
EMBO J. 2020 Nov 2;39(21):e103476. doi: 10.15252/embj.2019103476.
Karwelat D, Schmeck B, Ringel M, Benedikter BJ, Hübner K, Beinborn I, Maisner A, Schulte LN, Vollmeister E.
Influenza virus‐mediated suppression of bronchial Chitinase‐3‐like 1 secretion promotes secondary pneumococcal infection
Nerlich A, von Wunsch Teruel I, Mieth M, Hönzke K, Rückert JC, Mitchell TJ, Suttorp N, Hippenstiel S, Hocke AC.
Reversion of pneumolysin induced executioner caspase activation redirects cells to survival
J Infect Dis. 2020 Oct 12;jiaa639. doi: 10.1093/infdis/jiaa639.
Jung S, von Thülen T, Yang I, Laukemper V, Rupf B, Janga H, Panagiotidis GD, Schoen A, Nicolai M, Schulte LN, Obermann HL, Weber F, Kaufmann A, Bauer S
A ribosomal RNA fragment with 2',3'-cyclic phosphate and GTP-binding activity acts as RIG-I ligand
Nucleic Acids Res. 2020 Oct 9;48(18):10397-10412. doi: 10.1093/nar/gkaa739.
Linzner N, Fritsch VN, Busche T, Tung QN, Loi VV, Bernhardt J, Kalinowski J, Antelmann H.
The plant-derived naphthoquinone lapachol causes an oxidative stress response in Staphylococcus aureus
Free Radic Biol Med. 2020 Oct;158:126-136. doi: 10.1016/j.freeradbiomed.2020.07.025.
Myti D, Gunjak M, Casado F, Khaghani Raziabad S, Nardiello C, Vadasz I, Herold S, Pryhuber G, Seeger W, Morty RE.
Elevated FiO 2 increases SARS-CoV-2 co-receptor expression in respiratory tract epithelium
Am J Physiol Lung Cell Mol Physiol. 2020 Oct 1;319(4):L670-L674. doi: 10.1152/ajplung.00345.2020.
Scheuermann L, Pei G, Domaszewska T, Zyla J, Oberbeck-Müller D, Bandermann S, Feng Y, Ruiz Moreno JS, Opitz B, Mollenkopf HJ, Kaufmann SHE, Dorhoi A.
Platelets Restrict the Oxidative Burst in Phagocytes and Facilitate Primary Progressive Tuberculosis
Am J Respir Crit Care Med. 2020 Sep 1;202(5):730-744. doi: 10.1164/rccm.201910-2063OC. pubmed.ncbi.nlm.nih.gov/32421376/
Kreye J, Reincke SM, Kornau HC, Sanchez-Sendin E, Corman VM, Liu H, Yuan M, Wu NC, Zhu X, Lee CD, Trimpert J, Hoeltje M, Dietert K, Stoeffler L, von Wardenburg N, van Hoof S, Homeyer MA, Hoffmann J, Abdelgawad A, Gruber AD, Bertzbach LD, Vladimirova D, Li LY, Barthel PC, Skriner K, Hocke AC, Hippenstiel S, Witzenrath M, Suttorp N, Kurth F, Franke C, Endres M, Schmitz D, Jeworowski LM, Richter A, Schmidt ML, Schwarz T, Mueller MA, Drosten C, Wendisch D, Sander LE, Osterrieder N, Wilson IA, Pruess H.
A therapeutic non-self-reactive SARS-CoV-2 antibody protects from lung pathology in a COVID-19 hamster model.
Bertzbach LD, Vladimirova D, Dietert K, Abdelgawad A, Gruber AD, Osterrieder N, Trimpert J.
SARS-CoV-2 infection of Chinese hamsters (Cricetulus griseus) reproduces COVID-19 pneumonia in a well-established small animal model
Korfhage N, Mühling M, Ringshandl S, Becker A, Schmeck B, Freisleben B.
Detection and segmentation of morphologically complex eukaryotic cells in fluorescence microscopy images via feature pyramid fusion
Haralampiev I, Prisner S, Nitzan M, Schade M, Jolmes F, Schreiber M, Loidolt-Krüger M, Jongen K, Chamiolo J, Nilson N, Winter F, Friedman N, Seitz O, Wolff T, Herrmann A.
Selective flexible packaging pathways of the segmented genome of influenza A virus
Nat Commun. 2020 Aug 28;11(1):4355. doi: 10.1038/s41467-020-18108-1. https://pubmed.ncbi.nlm.nih.gov/32859915/
Hahn L, Helmrich N, Herebian D, Mayatepek E, Drebber U, Domann E, Olejniczak S, Weigel M, Hain T, Rath T, Wirtz S, Mollenkopf HJ, Schmidt N, Ewers C, Churin Y, Windhorst A, Weiskirchen R, Steinhoff U, Roeb E, Roderfeld M.
IL-13 as target to reduce cholestasis and dysbiosis in Abcb4 knockout mice.
Vega G, Guequén A, Philp AR, Gianotti A, Arzola L, Villalón M, Zegarra-Moran O, Galietta LJ, Mall MA, Flores CA.
Lack of Kcnn4 improves mucociliary clearance in muco-obstructive lung disease.
JCI Insight. 2020 Aug 20;5(16):e140076. doi: 10.1172/jci.insight.140076.
Mraheil MA, Toque HA, La Pietra L, Hamacher J, Phanthok T, Verin AD, Gonzales J, Su Y, Fulton D, Eaton DC, Chakraborty T, Lucas R.
Dual Role of Hydrogen Peroxide as an Oxidant in Pneumococcal Pneumonia.
Schulte-Schrepping J, Reusch N, Paclik D, Baßler K, Schlickeiser S, Zhang B, Krämer B, Krammer T, Brumhard S, Bonaguro L, De Domenico E, Wendisch D, Grasshoff M, Kapellos TS, Beckstette M, Pecht T, Saglam A, Dietrich O, Mei HE, Schulz AR, Conrad C, Kunkel D, Vafadarnejad E, Xu C-J, Horne A, Herbert M, Drews A, Thibeault C, Pfeiffer M, Hippenstiel S, Hocke A, Müller-Redetzky H, Heim K-M, Machleidt F, Uhrig A, Bosquillon de Jarcy L, Jürgens L, Stegemann M, Glösenkamp CR, Volk H-D, Goffinet C, Landthaler M, Wyler E, Georg P, Schneider M, Dang-Heine C, Neuwinger N, Kappert K, Tauber R, Corman V, Raabe J, Kaiser KM, To Vinh M, Rieke G, Meisel C, Ulas T, Becker M, Geffers R, Witzenrath M, Drosten C, Suttorp N, von Kalle C, Kurth F, Händler K, Schultze JL, Aschenbrenner AC, Li Y, Nattermann J, Sawitzki B, Saliba A-E, Sander LE
Severe COVID-19 is marked by a dysregulated myeloid cell compartment
Braun J , Loyal L, Frentsch M, Wendisch D , Georg P , Kurth F , Hippenstiel S, Dingeldey M, Kruse B, Fauchere F, Baysal E, Mangold M, Henze L, Lauster R, Mall MA, Beyer K, Röhmel J, Voigt S, Schmitz J, Miltenyi S, Demuth I, Müller MA, Hocke A, Witzenrath M, Suttorp N, Kern F, Reimer U, Wenschuh H, Drosten C, Corman VM, Giesecke-Thiel C, Sander LE, Thiel A
SARS-CoV-2-reactive T cells in healthy donors and patients with COVID-19
Messner CB, Demichev V, Wendisch D, Michalick L, White M, Freiwald A, Textoris-Taube K, Vernardis SI, Egger AS, Kreidl M, Ludwig D, Kilian C, Agostini F, Zelezniak A, Thibeault C, Pfeiffer M, Hippenstiel S, Hocke A, von Kalle C, Campbell A, Hayward C, Porteous DJ, Marioni RE, Langenberg C, Lilley KS, Kuebler WM, Mülleder M, Drosten C, Suttorp N, Witzenrath M, Kurth F, Sander LE, Ralser M
Ultra-High-Throughput Clinical Proteomics Reveals Classifiers of COVID-19 Infection
Osterrieder N, Bertzbach LD, Dietert K, Abdelgawad A, Vladimirova D, Kunec D, Hoffmann D, Beer M, Gruber AD, Trimpert J.
Age-Dependent Progression of SARS-CoV-2 Infection in Syrian Hamsters
Sauerhering L, Kupke A, Meier L, Dietzel E, Hoppe J, Gruber AD, Gattenloehner S, Witte B, Fink L, Hofmann N, Zimmermann T, Goesmann A, Nist A, Stiewe T, Becker S, Herold S, Peteranderl C.
Cyclophilin Inhibitors Restrict Middle East Respiratory Syndrome Coronavirus Via Interferon λ In Vitro And In Mice
Lorenz Chua R, Lukassen Soeren, Trump S, Hennig BP, Wendisch D, Pott F, Debnath O, Thürmann L, Kurth F, Völker MT, Kazmierski Julia, Timmermann B, Twardziok S, Schneider S, Machleidt F, Müller-Redetzky H , Maier M, Krannich A, Schmidt S, Balzer F, Liebig J, Loske J, Suttorp N, Eils J, Ishaque N, Liebert UG, von Kalle C, Hocke A, Witzenrath M, Goffinet C, Drosten C, Laudi S, Lehmann I, Conrad C, Sander LE, Eils R
COVID-19 severity correlates with airway epithelium-immune cell interactions identified by single-cell analysis
Taghizadeh S, Heiner M, Vazquez-Armendariz AI, Wilhelm J, Herold S, Chen C, Zhang JS, Bellusci S.
Characterization in mice of the resident mesenchymal niche maintaining AT2 stem cell proliferation in homeostasis and disease.
Stem Cells. 2021 Oct;39(10):1382-1394. doi: 10.1002/stem.3423. Epub 2021 Jun 15. PMID: 34048616. pubmed.ncbi.nlm.nih.gov/34048616/
Kurth F, Roennefarth M, Thibeault C, Corman VM, Müller-Redetzky H, Mittermaier M, Ruwwe-Glösenkamp C, Heim KM, Krannich A, Zvorc S, Schmidt S, Kretzler L, Dang-Heine C, Rose M, Hummel M, Hocke A, Hübner RH, Opitz B, Mall MA, Röhmel J, Landmesser U, Pieske B, Knauss S, Endres M, Spranger J, Mockenhaupt FP, Tacke F, Treskatsch S, Angermair S, Siegmund B, Spies C, Weber-Carstens S, Eckardt KU, Schürmann D, Uhrig A, Stegemann MS, Zoller T, Drosten C, Suttorp N, Witzenrath M, Hippenstiel S, von Kalle C, Sander LE.
Studying the pathophysiology of coronavirus disease 2019: a protocol for the Berlin prospective COVID-19 patient cohort (Pa-COVID-19).
Chillappagari S, Garapati V, Mahavadi P, Naehrlich L, Schmeck BT, Schmitz ML, Guenther A.
Defective BACH1/HO-1 regulatory circuits in cystic fibrosis bronchial epithelial cells
Kuebler W, Jordt SE, Liedtke WB
Urgent reconsideration of lung edema as a preventable outcome in COVID-19: inhibition of TRPV4 represents a promising and feasible approach
Am J Physiol Lung Cell Mol Physiol. 2020 Jun 1;318(6):L1239-L1243
Jagdmann S, Dames C, Berchtold D, Winek K, Weitbrecht L, Meisel A, Meisel C.
Impact of Key Nicotinic AChR Subunits on Post-Stroke Pneumococcal Pneumonia
Vaccines (Basel). 2020 May 28;8(2):253. doi: 10.3390/vaccines8020253. https://pubmed.ncbi.nlm.nih.gov/32481512/
Thi Nhu Thao T, Labroussaa F, Ebert N, V'kovski P, Stalder H, Portmann J, Kelly J, Steiner S, Holwerda M, Kratzel A, Gultom M, Schmied K, Laloli L, Hüsser L, Wider M, Pfaender S, Hirt D, Cippà V, Crespo-Pomar S, Schröder S, Muth D, Niemeyer D, Corman VM, Müller MA, Drosten C, Dijkman R, Jores J, Thiel V.
Rapid reconstruction of SARS-CoV-2 using a synthetic genomics platform
Walther T, Kuebler WM
Don't judge too RAShly: the multifaceted role of the renin-angiotensin system and its therapeutic potential in COVID-19.
Am J Physiol Lung Cell Mol Physiol. 2020 May 1;318(5):L1023-L1024.
Schaupp L, Muth S, Rogell L, Kofoed-Branzk M, Melchior F, Lienenklaus S, Ganal-Vonarburg SC, Klein M, Guendel F, Hain T, Schütze K, Grundmann U, Schmitt V, Dorsch M, Spanier J, Larsen PK, Schwanz T, Jäckel S, Reinhardt C, Bopp T, Danckwardt S, Mahnke K, Heinz GA, Mashreghi MF, Durek P, Kalinke U, Kretz O, Huber TB, Weiss S, Wilhelm C, Macpherson AJ, Schild H, Diefenbach A, Probst HC
Microbiota-Induced Type I Interferons Instruct a Poised Basal State of Dendritic Cells.
Ochs M, Hegermann J, Lopez-Rodriguez E, Timm S, Nouailles G, Matuszak J, Simmons S, Witzenrath M, Kuebler WM.
On Top of the Alveolar Epithelium: Surfactant and the Glycocalyx
Int J Mol Sci. 2020 Apr 27;21(9):3075. doi: 10.3390/ijms21093075.
Duerr J, Leitz DHW, Szczygiel M, Dvornikov D, Fraumann SG Kreutz C, Zadora PK, Seyhan Agircan A Konietzke P, Engelmann TA, Hegermann J, Mulugeta S, Kawabe H, Knudsen L, Ochs M, Rotin D, Muley T, Kreuter M, Herth FJF, Wielpütz MO, Beers MF, Klingmüller U, Mall MA
Conditional deletion of Nedd4-2 in lung epithelial cells causes progressive pulmonary fibrosis in adult mice.
Van Loi V, Antelmann H.
Method for measurement of bacillithiol redox potential changes using the Brx-roGFP2 redox biosensor in Staphylococcus aureus
MethodsX. 2020 Apr 24;7:100900. doi: 10.1016/j.mex.2020.100900.
Perniss A, Latz A, Boseva I, Papadakis T, Dames C, Meisel C, Meisel A, Scholze P, Kummer W, Krasteva-Christ G
Acute nicotine administration stimulates ciliary activity via α3β4 nAChR in the mouse trachea.
Perniss A, Liu S, Boonen B, Keshavarz M, Ruppert AL, Timm T, Pfeil U, Soultanova A, Kusumakshi S, Delventhal L, Aydin Ö, Pyrski M, Deckmann K, Hain T, Schmidt N, Ewers C, Günther A, Lochnit G, Chubanov V, Gudermann T, Oberwinkler J, Klein J, Mikoshiba K, Leinders-Zufall T, Offermanns S, Schütz B, Boehm U, Zufall F, Bufe B, Kummer W
Chemosensory Cell-Derived Acetylcholine Drives Tracheal Mucociliary Clearance in Response to Virulence-Associated Formyl Peptides.
Aznaourova M, Janga H, Sefried S, Kaufmann A, Dorna J, Volkers SM, Georg P, Lechner M, Hoppe J, Dökel S, Schmerer N, Gruber AD, Linne U, Bauer S, Sander LE, Schmeck B, Schulte LN
Noncoding RNA MaIL1 is an integral component of the TLR4–TRIF pathway.
Lucas R, Hadizamani Y, Gonzales J, Gorshkov B, Bodmer T, Berthiaume Y, Moehrlen U, Lode H, Huwer H, Hudel M, Mraheil MA, Toque HAF, Chakraborty T, Hamacher J.
Impact of Bacterial Toxins in the Lungs
Toxins (Basel). 2020 Apr 2;12(4):223. doi: 10.3390/toxins12040223. https://pubmed.ncbi.nlm.nih.gov/32252376/
Wölfel R, Corman VM, Guggemos W, Seilmaier M, Zange S, Müller MA, Niemeyer D, Jones TC, Vollmar P, Rothe C, Hoelscher M, Bleicker T, Brünink S, Schneider J, Ehmann R, Zwirglmaier K, Drosten C, Wendtner C
Virological assessment of hospitalized patients with COVID-2019.
Müller-Redetzky H, Kellermann U, Wienhold SM, Gutbier B, Lienau J, Hellwig K, Reppe K, Letsiou E, Tschernig T, Scholz M, Ahnert P, Maasch C, Hoehlig K, Klussmann S, Vater A, Firsching TC, Hoppe J, Suttorp N, Witzenrath M.
Neutralizing Complement C5a Protects Mice with Pneumococcal Pulmonary Sepsis
Sodemann EB, Dähling S, Klopfleisch R, Boiarina E, Cataldo D, Alhasan MM, Yildirim AÖ, Witzenrath M, Tabeling C, Conrad ML.
Maternal asthma is associated with persistent changes in allergic offspring antibody glycosylation
Clin Exp Allergy. 2020 Apr;50(4):520-531. doi: 10.1111/cea.13559.
Lauster D, Klenk S, Ludwig K, Nojoumi S, Behren S, Adam L, Stadtmüller M, Saenger S, Zimmler S, Hönzke K, Yao L, Hoffmann U, Bardua M, Hamann A, Witzenrath M, Sander LE, Wolff T, Hocke AC, Hippenstiel S, De Carlo S, Neudecker J, Osterrieder K, Budisa N, Netz RR, Böttcher C, Liese S, Herrmann A, Hackenberger CPR
Phage capsid nanoparticles with defined ligand arrangement block influenza virus entry
Herkt CE, Caffrey BE, Surmann K, Blankenburg S, Gesell Salazar M, Jung AL, Herbel SM, Hoffmann K, Schulte LN, Chen W, Sittka-Stark A, Völker U, Vingron M, Marsico A, Bertrams W, Schmeck B.
A MicroRNA Network Controls Legionella pneumophila Replication in Human Macrophages via LGALS8 and MX1.
Brown R, Paulsen M, Schmidt S, Schatterny J, Frank A, Hirtz S, Delaney R, Doherty D, Hagner M, Taggart C, Weldon S, Mall MA
Lack of IL-1 receptor signaling reduces spontaneous airway eosinophilia in juvenile mice with muco-obstructive lung disease.
Hagner M, Frey DL, Guerra M, Dittrich AS, Halls VS, Wege S, Herth FJF, Schultz C, Mall MA
New method for rapid and dynamic quantification of elastase activity on sputum neutrophils from patients with cystic fibrosis using flow cytometry.
Rohilla S, Krämer B, Koberling F, Gregor I, Hocke AC.
Multi-target immunofluorescence by separation of antibody cross-labelling via spectral-FLIM-FRET
Hotter B, Hoffmann S, Ulm L, Montaner J, Bustamante A, Meisel C, Meisel A.
Inflammatory and stress markers predicting pneumonia, outcome, and etiology in patients with stroke: Biomarkers for predicting pneumonia, functional outcome, and death after stroke
Neurol Neuroimmunol Neuroinflamm. 2020 Feb 25;7(3):e692. doi: 10.1212/NXI.0000000000000692. Print 2020 May. https://pubmed.ncbi.nlm.nih.gov/32098866/
Schulte LN, Schweinlin M, Westermann AJ, Janga H, Santos SC, Appenzeller S, Walles H, Vogel J, Metzger M
An Advanced Human Intestinal Coculture Model Reveals Compartmentalized Host and Pathogen Strategies during Salmonella Infection.
La Pietra L, Hudel M, Pillich H, Abu Mraheil M, Berisha B, Aden S, Hodnik V, Lochnit G, Rafiq A, Perniss A, Anderluh G, Chakraborty T
Phosphocholine antagonizes listeriolysin O-induced host cell responses of Listeria monocytogenes.
Wahl M, Röhlicke T, Kulisch S, Rohilla S, Krämer B, Hocke AC.
Photon arrival time tagging with many channels, sub-nanosecond deadtime, very high throughput, and fiber optic remote synchronization
McKelvey MC, Weldon S, McAuley DF, Mall MA, Taggart CC
Targeting proteases in cystic fibrosis lung disease: Paradigms, progress, and potential.
Bertrams W, Griss K, Han M, Seidel K, Klemmer A, Sittka-Stark A, Hippenstiel S, Suttorp N, Finkernagel F, Wilhelm J, Greulich T, Vogelmeier C, Vera J, Schmeck B
Transcriptional analysis identifies potential biomarkers and molecular regulators in pneumonia and COPD exacerbation.
Bell SC, Mall MA, Gutierrez H, Macek M, Madge S, Davies JC, Burgel PR, Tullis E, Castanos C, Castellani C, Byrnes CA, Cathcart F, Chotirmall SH, Cosgriff R, Eichler I, Fajac I, Goss CH, Drevinek P, Farrell PM, Gravelle AM, Havermans T, Mayer-Hamblett N, Kashirskaya N, Kerem E, Mathew JL, McKone EF, Naehrlich L, Nasr SZ, Oates GR, O'Neill C, Pypops U, Raraigh KS, Rowe SM, Southern KW, Sivam S, Stephenson AL, Zampoli M, Ratjen F
The future of cystic fibrosis care: A global perspective.
Erickson NA, Gruber AD, Mundhenk L.
The Family of Chloride Channel Regulator, Calcium-activated Proteins in the Feline Respiratory Tract: A Comparative Perspective on Airway Diseases in Man and Animal Models
J Comp Pathol. 2020 Jan;174:39-53. doi: 10.1016/j.jcpa.2019.10.193.
Mall MA, Mayer-Hamblett N, Rowe SM
Cystic fibrosis: Emergence of highly effective targeted therapeutics and potential clinical implications.
Lückel C, Picard F, Raifer H, Campos Carrascosa L, Guralnik A, Zhang Y, Klein M, Bittner S, Steffen F, Moos S, Marini F, Gloury R, Kurschus FC, Chao YY, Bertrams W, Sexl V, Schmeck B, Bonetti L, Grusdat M, Lohoff M, Zielinski CE, Zipp F, Kallies A, Brenner D, Berger M, Bopp T, Tackenberg B, Huber M
IL-17+ CD8+ T cell suppression by dimethyl fumarate associates with clinical response in multiple sclerosis.
Hübner K, Karwelat D, Pietsch E, Beinborn I, Winterberg S, Bedenbender K, Benedikter BJ, Schmeck B, Vollmeister E
NF-κB-mediated inhibition of microRNA-149-5p regulates Chitinase-3-like 1 expression in human airway epithelial cells.
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The Randomized Controlled STRAWINSKI Trial: Procalcitonin-Guided Antibiotic Therapy after Stroke
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Biochem Pharmacol. 2016 Dec 22. pii: S0006-2952(16)30494-4.
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Cell Chem Biol. 2016 Nov 2. pii: S2451-9456(16)30356-7
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J Allergy Clin Immunol. 2016 Jul;138(1):47-56
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PLoS Pathog. 2016 Jun 20;12(6):e1005544
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Arch Virol. 2016 Jun;161(6):1505-15
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Stroke. 2016 May;47(5):1354-63
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Legionella pneumophila-derived outer membrane vesicles promote bacterial replication in macrophages.
PLoS Pathog. 2016 Apr 22;12(4)
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J Clin Invest. 2016 Apr 1;126(4):1566-80
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J Infect Dis. 2016 Mar 16
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PKCα Deficiency in Mice Is Associated with Pulmonary Vascular Hyperresponsiveness to Thromboxane A2 and Increased Thromboxane Receptor Expression.
J Vasc Res. 2015;52(4):279-88
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Influenza virus damages the alveolar barrier by disrupting epithelial cell tight junctions.
Eur Respir J. 2016 Mar;47(3):954-66
Yin J, Michalick L, Tang C, Tabuchi A, Goldenberg N, Dan Q, Awwad K, Wang L, Erfinanda L, Nouailles G, Witzenrath M, Vogelzang A, Lv L, Lee WL, Zhang H, Rotstein O, Kapus A, Szaszi K, Fleming I, Liedtke WB, Kuppe H, Kuebler WM
Role of transient receptor potential vanilloid 4 in neutrophil activation and acute lung injury.
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IFNs Modify the Proteome of Legionella-Containing Vacuoles and Restrict Infection Via IRG1-Derived Itaconic Acid.
PLoS Pathog. 2016 Feb 1;12(2)
Hoffmann S, Harms H, Ulm L, Nabavi DG, Mackert BM, Schmehl I, Jungehulsing GJ, Montaner J, Bustamante A, Hermans M, Hamilton F, Göhler J, Malzahn U, Malsch C, Heuschmann PU, Meisel C, Meisel A
Stroke-induced immunodepression and dysphagia independently predict stroke-associated pneumonia - The PREDICT study.
J Cereb Blood Flow Metab. 2016 Jan 1:271678X16671964
Reppe K, Radünzel P, Dietert K, Tschernig T, Wolff T, Hammerschmidt S, Gruber AD, Suttorp N, Witzenrath M
Pulmonary immunostimulation with MALP-2 in influenza virus-infected mice increases survival after pneumococcal superinfection.
Infect Immun. 2015 Dec;83(12):4617-29
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Luminal acetylcholine does not affect the activity of the CFTR in tracheal epithelia of pigs.
Int Immunopharmacol. 2015 Nov;29(1):166-72
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Stroke: Preventive antibiotics for stroke-associated pneumonia.
Nat Rev Neurol. 2015 Nov 3
Engel O, Akyüz L, da Costa Goncalves AC, Winek K, Dames C, Thielke M, Herold S, Böttcher C, Priller J, Volk HD, Dirnagl U, Meisel C, Meisel A
Cholinergic pathway suppresses pulmonary innate immunity facilitating pneumonia after stroke.
Stroke. 2015 Nov;46(11):3232-40
Hackstein H, Lippitsch A, Krug P, Schevtschenko I, Kranz S, Hecker M, Dietert K, Gruber AD, Bein G, Brendel C, Baal N
Prospectively defined murine mesenchymal stem cells inhibit Klebsiella pneumoniae-induced acute lung injury and improve pneumonia survival.
Respir Res. 2015 Oct 6;16:123
Zahlten J, Herta T, Kabus C, Steinfeldt M, Kershaw O, García P, Hocke AC, Gruber AD, Hübner RH, Steinicke R, Doehn JM, Suttorp N, Hippenstiel S
Role of Pneumococcal Autolysin for KLF4 Expression and Chemokine Secretion in Lung Epithelium.
Am J Respir Cell Mol Biol. 2015 Oct;53(4):544-54
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Eur Respir Rev. 2015 Sep;24(137):516-24
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Fisetin protects against Listeria monocytogenes infection by reducing the listeriolysin O production.
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Serotype 1 and 8 Pneumococci Evade Sensing by Inflammasomes in Human Lung Tissue.
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Moraxella catarrhalis induces an immune response in the murine lung that is independent of human CEACAM5 expression and long-term smoke exposure.
Am J Physiol Lung Cell Mol Physiol. 2015 Aug 1;309(3):L250-61
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Fluorescence-Activated Cell Sorting-Based Analysis Reveals an Asymmetric Induction of Interferon-Stimulated Genes in Response to Seasonal Influenza A Virus.
J Virol. 2015 Jul 15;89(14):6982-93
Soultanova A, Voigt A, Chubanov V, Gudermann T, Meyerhof W, Boehm U, Kummer W
Cholinergic chemosensory cells of the thymic medulla express the bitter receptor Tas2r131.
Int Immunopharmacol. 2015 Nov;29(1):143-7
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Diagnosis of Stroke-Associated Pneumonia: Recommendations From the Pneumonia in Stroke Consensus Group.
Stroke. 2015 Jun 25. pii: STROKEAHA.115.009617.
Mühlbauer D, Dzieciolowski J, Hardt M, Hocke A, Schierhorn KL, Mostafa A, Müller C, Wisskirchen C, Herold S, Wolff T, Ziebuhr J, Pleschka S
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J Virol. 2015 Jun 1;89(11):6009-21
Jung S, von Thulen T, Laukemper V, Pigisch S, Hangel D, Wagner H, Kaufmann A, Bauer S
A single naturally occurring 2'-O-methylation converts a TLR7- and TLR8-activating RNA into a TLR8-specific ligand.
A single naturally occurring 2'-O-methylation converts a TLR7- and TLR8-activating RNA into a TLR8-specific ligand.
Hecker M, Linder T, Ott J, Walmrath HD, Lohmeyer J, Vadász I, Marsh LM, Herold S, Reichert M, Buchbinder A, Morty RE, Bausch B, Fischer T, Schulz R, Grimminger F, Witzenrath M, Barnes M, Seeger W, Mayer K
Immunomodulation by lipid emulsions in pulmonary inflammation: a randomized controlled trial.
Crit Care. 2015 May 12;19:226
Müller-Redetzky HC, Wienhold SM, Berg J, Hocke AC, Hippenstiel S, Hellwig K, Gutbier B, Opitz B, Neudecker J, Rückert J, Gruber AC, Kershaw O, Mayer K, Suttorp N, Witzenrath M
Moxifloxacin is not anti-inflammatory in experimental pneumococcal pneumonia.
J Antimicrob Chemother. 2015 Mar;70(3):830-40
Kishore AK, Vail A, Chamorro A, Garau J, Hopkins SJ, Di Napoli M, Kalra L, Langhorne P, Montaner J, Roffe C, Rudd AG, Tyrrell PJ, van de Beek D, Woodhead M, Meisel A, Smith CJ
How is pneumonia diagnosed in clinical stroke research? A systematic review and meta-analysis.
Stroke. 2015 May;46(5):1202-9.
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Preventive antibiotic therapy in stroke: PASSed away?
Lancet. 2015 Apr 18;385(9977):1486-7
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CFTR and sphingolipids mediate hypoxic pulmonary vasoconstriction.
Proc Natl Acad Sci U S A. 2015 Mar 31;112(13):E1614-23
Didiasova M, Zakrzewicz D, Magdolen V, Nagaraj C, Bálint Z, Rohde M, Preissner KT, Wygrecka M
STIM1/ORAI1-mediated Ca2+ Influx Regulates Enolase-1 Exteriorization.
J Biol Chem. 2015 May 8;290(19):11983-99
Wujak L, Didiasova M, Zakrzewicz D, Frey H, Schaefer L, Wygrecka M
Heparan sulfate proteoglycans mediate factor XIIa binding to the cell surface.
J Biol Chem. 2015 Mar 13;290(11):7027-39
Zahlten J, Herta T, Kabus C, Steinfeldt M, Kershaw O, García P, Hocke AC, Gruber AD, Hübner RH, Steinicke R, Doehn JM, Suttorp N, Hippenstiel S
Pneumococci LytA-dependent KLF4 Expression Terminates IL-8 Secretion in Lung Epithelium.
Am J Respir Cell Mol Biol. 2015 Mar 10
Dietert K, Mundhenk L, Erickson NA, Reppe K, Hocke AC, Kummer W, Witzenrath M, Gruber AD
Murine CLCA5 is uniquely expressed in distinct niches of airway epithelial cells.
Histochem Cell Biol. 2015 Mar;143(3):277-87. doi: 10.1007/s00418-014-1279-x.
Cabrera-Fuentes HA, Lopez ML, McCurdy S, Fischer S, Meiler S, Baumer Y, Galuska SP, Preissner KT, Boisvert WA
Regulation of monocyte/macrophage polarisation by extracellular RNA.
Thromb Haemost. 2015 Mar;113(3):473-81
Rabes A, Zimmermann S, Reppe K, Lang R, Seeberger PH, Suttorp N, Witzenrath M, Lepenies B, Opitz B
The C-type lectin receptor Mincle binds to Streptococcus pneumoniae but plays a limited role in the anti-pneumococcal innate immune response.
PLoS One. 2015 Feb 6;10(2):e0117022
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Increasing the inspiratory time and I:E ratio during mechanical ventilation aggravates ventilator-induced lung injury in mice.
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Loose M, Hudel M, Zimmer KP, Garcia E, Hammerschmidt S, Lucas R, Chakraborty T, Pillich H
Pneumococcal hydrogen peroxide-induced stress signaling regulates inflammatory genes.
J Infect Dis. 2015 Jan 15;211(2):306-16
Zahlten J, Kim YJ, Doehn JM, Pribyl T, Hocke AC, García P, Hammerschmidt S, Suttorp N, Hippenstiel S, Hübner RH
Streptococcus pneumoniae-Induced Oxidative Stress in Lung Epithelial Cells Depends on Pneumococcal Autolysis and Is Reversible by Resveratrol.
J Infect Dis. 2015 Jun 1;211(11):1822-1830
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Seifert U, Bialy LP, Ebstein F, Bech-Otschir D, Voigt A, Schröter F, Prozorovski T, Lange N, Steffen J, Rieger M, Kuckelkorn U, Aktas O, Kloetzel PM, Krüger E
Immunoproteasomes preserve protein homeostasis upon interferon-induced oxidative stress
Cell 142, 613-622 (2010)
Zahlten J, Steinicke R, Opitz B, Eitel J, N´guessan PD, Vinzing M, Witzenrath M, Schmeck B, Hammerschmidt S, Suttorp N, Hippenstiel S.
TLR2- and nucleotide-binding oligomerization domain 2-dependent Krüppel-like factor 2 expression downregulates NF-kappa B-related gene expression.
J Immunol. 2010 Jul 1;185(1):597-604. Epub 2010 Jun 4
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