Transregio SFB-TR 84 “Innate Immunity of the Lung: Mechanisms of Pathogen Attack and Host Defence in Pneumonia“

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Publications

Herbel SM, Moyon L, Christ M, Elsayed EM, Caffrey BE, Malmsheimer S, Grin I, Hoffmann K, Surmann K, Blankenburg S, Jung AL, Herkt CE, Borsò M, Bozdag B, Imhof A, Becker A, Wagner S, Bange G, Völker U, Bertrams W, Marsico A, Schmeck B.

Microbiota-dependent regulation of antimicrobial immunity in the lung

Am J Respir Cell Mol Biol. 2019 Sep;61(3):284-289. doi: 10.1165/rcmb.2019-0101TR. 
https://pubmed.ncbi.nlm.nih.gov/31059654/

Fiocca Vernengo F, Opitz B.

TBK1's role in bacterial pneumonia: Perhaps more than macrophages and IFNs

Am J Respir Cell Mol Biol. 2022 Jun;66(6):596-597. doi: 10.1165/rcmb.2022-0040ED.
https://pubmed.ncbi.nlm.nih.gov/35363998/

Herbel SM, Moyon L, Christ M, Elsayed EM, Caffrey BE, Malmsheimer S, Grin I, Hoffmann K, Surmann K, Blankenburg S, Jung AL, Herkt CE, Borsò M, Bozdag B, Imhof A, Becker A, Wagner S, Bange G, Völker U, Bertrams W, Marsico A, Schmeck B.

Screening for eukaryotic motifs in Legionella pneumophila reveals Smh1 as bacterial deacetylase of host histones

Virulence 2022 Dec;13(1):2042-2058.
doi: 10.1080/21505594.2022.2149973. https://pubmed.ncbi.nlm.nih.gov/36411449/

Klatt AB, Diersing C, Lippmann J, Mayer-Lambertz S, Stegmann F, Fischer S, Caesar S, Fiocca Vernengo F, Hönzke K, Hocke AC, Ruland J, Witzenrath M, Lepenies B, Opitz B

CLEC12A binds to Legionella pneumophila but has no impact on the host's antibacterial response

Int J Mol Sci. 2023 Feb 15;24(4):3891. doi: 10.3390/ijms24043891.​​​​​​https://pubmed.ncbi.nlm.nih.gov/36835297/

Erfinanda L, Zou L, Gutbier B, Kneller L, Weidenfeld S, Michalick L, Lei D, Reppe K, Teixeira Alves LG, Schneider B, Zhang Q, Li C, Fatykhova D, Schneider P, Liedtke W, Sohara E, Mitchell TJ, Gruber AD, Hocke A, Hippenstiel S, Suttorp N, Olschewski A, Mall MA, Witzenrath M, Kuebler WM

Loss of endothelial CFTR drives barrier failure and edema formation in lung infection and can be targeted by CFTR potentiation

Sci Transl Med. 2022 Dec 7;14(674):eabg8577.
doi: 10.1126/scitranslmed.abg8577. https://pubmed.ncbi.nlm.nih.gov/36475904/

Hönzke K, Obermayer B, Mache C, Fathykova D, Kessler M, Dökel S, Wyler E, Baumgardt M, Löwa A, Hoffmann K, Graff P, Schulze J, Mieth M, Hellwig K, Demir Z, Biere B, Brunotte L, Mecate-Zambrano A, Bushe J, Dohmen M, Hinze C, Elezkurtaj S, Tönnies M, Bauer TT, Eggeling S, Tran HL, Schneider P, Neudecker J, Rückert JC, Schmidt-Ott KM, Busch J, Klauschen F, Horst D, Radbruch H, Radke J, Heppner F, Corman VM, Niemeyer D, Müller MA, Goffinet C, Mothes R, Pascual-Reguant A, Hauser AE, Beule D, Landthaler M, Ludwig S, Suttorp N, Witzenrath M, Gruber AD, Drosten C, Sander LE, Wolff T, Hippenstiel S, Hocke AC

Human lungs show limited permissiveness for SARS-CoV-2 due to scarce ACE2 levels but virus-induced expansion of inflammatory macrophages

Eur Respir J. 2022 Dec 1;60(6):2102725. doi: 10.1183/13993003.02725-2021. 
https://pubmed.ncbi.nlm.nih.gov/35728978/

Bertrams W, Hönzke K, Obermayer B, Tönnies M, Bauer TT, Schneider P, Neudecker J, Rückert JC, Stiewe T, Nist A, Eggeling S, Suttorp N, Wolff T, Hippenstiel S, Schmeck B, Hocke AC

Transcriptomic comparison of primary human lung cells with lung tissue samples and the human A549 lung cell line highlights cell type specific responses during infections with influenza A virus

Sci Rep 12, 2022 Nov 29;12(1):20608.
doi 10.1038/s41598-022-24792-4. https://pubmed.ncbi.nlm.nih.gov/36446841/

Lopez Krol A, Nehring HP, Krause FF, Wempe A, Raifer H, Nist A, Stiewe T, Bertrams W, Schmeck B, Luu M, Leister H, Chung HR, Bauer UM, Adhikary T, Visekruna A.

Lactate induces metabolic and epigenetic reprogramming of pro-inflammatory Th17 cells

EMBO Rep. 2022 Oct 10;e54685. doi: 10.15252/embr.202254685. https://pubmed.ncbi.nlm.nih.gov/36215678/

Aznaourova M, Schmerer N, Janga H, Zhang Z, Pauck K, Bushe J, Volkers SM, Wendisch D, Georg P, Ntini E, Aillaud M, Gündisch M, Mack E, Skevaki C, Keller C, Bauer C, Bertrams W, Marsico A, Nist A, Stiewe T, Gruber AD, Ruppert C, Li Y, Garn H, Sander LE, Schmeck B, Schulte LN.

Single-cell RNA sequencing uncovers the nuclear decoy lincRNA PIRAT as a regulator of systemic monocyte immunity during COVID-19

Proc Natl Acad Sci USA. 2022 Sep 6;119(36):e2120680119. doi: 10.1073/pnas.2120680119. Epub 2022 Aug 23. https://pubmed.ncbi.nlm.nih.gov/35998224/

Kunec D, Osterrieder N, Trimpert J.

Synthetically recoded virus sCPD9 – A tool to accelerate SARS-CoV-2 research under biosafety level 2 conditions

Comput Struct Biotechnol J . 2022;20:4376-4380. doi: 10.1016/j.csbj.2022.08.027. Epub 2022 Aug 13. https://pubmed.ncbi.nlm.nih.gov/35992535/

Hoffmann K, Obermayer B, Hönzke K, Fatykhova D, Demir Z, Löwa A, Alves LGT, Wyler E, Lopez-Rodriguez E, Mieth M, Baumgardt M, Hoppe J, Firsching TC, Tönnies M, Bauer TT, Eggeling S, Tran HL, Schneider P, Neudecker J, Rückert JC, Gruber AD, Ochs M, Landthaler M, Beule D, Suttorp N, Hippenstiel S, Hocke AC, Kessler M.

Human alveolar progenitors generate dual lineage bronchioalveolar organoids

Commun Biol. 2022 Aug 25;5(1):875. doi: 10.1038/s42003-022-03828-5. https://pubmed.ncbi.nlm.nih.gov/36008580/

Hülsemann M, Wiebach J, Drude NI, Kniffert S, Behm L, Hönzke K, Baumgardt M, Hippenstiel S, Hocke AC, Dirnagl U, Tölch U.

Introducing quality measures in an academic research consortium: Lessons and recommendation from implementing an ad hoc quality management system for organ model research

EMBO Rep. 2022 Aug 3;23(8):e55095. doi: 10.15252/embr.202255095. Epub 2022 Jul 25. https://pubmed.ncbi.nlm.nih.gov/35876564/

Pennitz P, Kirsten H, Friedrich VD, Wyler E, Goekeri C, Obermayer B, Heinz GA, Mashreghi MF, Büttner M, Trimpert J, Landthaler M, Suttorp N, Hocke AC, Hippenstiel S, Tönnies M, Scholz M, Kuebler WM, Witzenrath M, Hoenzke K, Nouailles G.

A pulmonologist's guide to perform and analyse cross-species single lung cell transcriptomics

Eur Respir Rev. 2022 Jul 27;31(165):220056. doi: 10.1183/16000617.0056-2022. https://pubmed.ncbi.nlm.nih.gov/35896273/

Schmiedeknecht K, Kaufmann A, Bauer S, Venegas Solis F.

L-lactate as an indicator for cellular metabolic status: An easy and cost-effective colorimetric L-lactate assay

PLoS One. 2022 Jul 22;17(7):e0271818. doi: 10.1371/journal.pone.0271818. https://pubmed.ncbi.nlm.nih.gov/35867690/

Hollenhorst MI, Nandigama R, Evers SB, Gamayun I, Abdel Wadood N, Salah A, Pieper M, Wyatt A, Stukalov A, Gebhardt A, Nadolni W, Burow W, Herr C, Beisswenger C, Kusumakshi S, Ectors F, Kichko TI, Hübner L, Reeh P, Munder A, Wienhold SM, Witzenrath M, Bals R, Flockerzi V, Gudermann T, Bischoff M, Lipp P, Zierler S, Chubanov V, Pichlmair A, König P, Boehm U, Krasteva-Christ G.

Bitter taste signaling in tracheal epithelial brush cells elicits innate immune responses to bacterial infection.

J Clin Invest. 2022; 132(13):e150951. https://pubmed.ncbi.nlm.nih.gov/35503420/

Hönzke K, Obermayer B, Mache C, Fathykova D, Kessler M, Dökel S, Wyler E, Baumgardt M, Löwa A, Hoffmann K, Graff P, Schulze J, Mieth M, Hellwig K, Demir Z, Biere B, Brunotte L, Mecate-Zambrano A, Bushe J, Dohmen M, Hinze C, Elezkurtaj S, Tönnies M, Bauer TT, Eggeling S, Tran HL, Schneider P, Neudecker J, Rückert JC, Schmidt-Ott KM, Busch J, Klauschen F, Horst D, Radbruch H, Radke J, Heppner F, Corman VM, Niemeyer D, Müller MA, Goffinet C, Mothes R, Pascual-Reguant A, Hauser AE, Beule D, Landthaler M, Ludwig S, Suttorp N, Witzenrath M, Gruber AD, Drosten C, Sander LE, Wolff T, Hippenstiel S, Hocke AC.

Human lungs show limited permissiveness for SARS-CoV-2 due to scarce ACE2 levels but virus-induced expansion of inflammatory macrophages

Eur Respir J. 2022 Jun 21;2102725. doi: 10.1183/13993003.02725-2021. https://pubmed.ncbi.nlm.nih.gov/35728978/

Margaroli C, Horati H, Garratt LW, Giacalone VD, Schofield C, Dittrich AS, Rosenow T, Dobosh BS, Lim HS, Frey DL, Veltman M, Silva GL, Brown MR, Schultz C, Tiddens HAWM, Ranganathan S, Chandler JD, Qiu P, Peng L, Scholte BJ, Mall MA, Kicic A, Guglani L, Stick SM, Janssens HM, Tirouvanziam R.

Macrophage PD-1 associates with neutrophilia and reduced bacterial killing in early cystic fibrosis airway disease

J Cyst Fibros. 2022 Jun 19;S1569-1993(22)00588-4. doi: 10.1016/j.jcf.2022.06.001. https://pubmed.ncbi.nlm.nih.gov/35732550/

Tabeling C, González Calera CR, Lienau J, Höppner J, Tschernig T, Kershaw O, Gutbier B, Naujoks J, Herbert J, Opitz B, Gruber AD, Hocher B, Suttorp N, Heidecke H, Burmester GR, Riemekasten G, Siegert E, Kuebler WM, Witzenrath M.

Endothelin B Receptor Immunodynamics in Pulmonary Arterial Hypertension.

Front Immunol. 2022 Jun 9;13:895501. https://pubmed.ncbi.nlm.nih.gov/35757687/

Dannebaum R, Suwalski P, Asgharian H, Du Zhipei G, Lin H, Weiner J, Holtgrewe M, Thibeault C, Müller M, Wang X, Karadeniz Z, Saccomanno J, Doehn JM, Hübner RH, Hinzmann B, Blüher A, Siemann S, Telman D, Suttorp N, Witzenrath M, Hippenstiel S, Skurk C, Poller W, Sander LE, Beule D, Kurth F, Guettouche T, Landmesser U, Berka J, Luong K; Pa-COVID Study Group, Rubelt F, Heidecker B.

Highly multiplexed immune repertoire sequencing links multiple lymphocyte classes with severity of response to COVID-19.

EClinicalMedicine. 2022 Jun;48:101438. https://pubmed.ncbi.nlm.nih.gov/35600330/

Frey DL, Bridson C, Dittrich S, Graeber SY, Stahl M, Wege S, Herth F, Sommerburg O, Schultz C, Dalpke A, Mall MA, Boutin S.

Changes in Microbiome Dominance Are Associated With Declining Lung Function and Fluctuating Inflammation in People With Cystic Fibrosis

Front Microbiol. 2022 May 13;13:885822. doi: 10.3389/fmicb.2022.885822. eCollection 2022. https://pubmed.ncbi.nlm.nih.gov/35633718/

Patrono LV, Vrancken B, Budt M, Düx A, Lequime S, Boral S, Gilbert MTP, Gogarten JF, Hoffmann L, Horst D, Merkel K, Morens D, Prepoint B, Schlotterbeck J, Schuenemann VJ, Suchard MA, Taubenberger JK, Tenkhoff L, Urban C, Widulin N, Winter E, Worobey M, Schnalke T, Wolff T, Lemey P, Calvignac-Spencer S.

Archival influenza virus genomes from Europe reveal genomic variability during the 1918 pandemic

Nat Commun. 2022 May 10;13(1):2314. doi: 10.1038/s41467-022-29614-9. https://pubmed.ncbi.nlm.nih.gov/35538057/

Wyler E, Adler JM, Eschke K, Teixeira Alves G, Peidli S, Pott F, Kazmierski J, Michalick L, Kershaw O, Bushe J, Andreotti S, Pennitz P, Abdelgawad A, Postmus D, Goffinet C, Kreye J, Reincke SM, Prüss H, Blüthgen N, Gruber AD, Kuebler WM, Witzenrath M, Landthaler M, Nouailles G, Trimpert J.

Key benefits of dexamethasone and antibody treatment in COVID-19 hamster models revealed by single-cell transcriptomics

Mol Ther. 2022 May 4;30(5):1952-1965. doi: 10.1016/j.ymthe.2022.03.014. Epub 2022 Mar 24. https://pubmed.ncbi.nlm.nih.gov/35339689/

Lingscheid T, Lippert LJ, Hillus D, Kruis T, Thibeault C, Helbig ET, Tober-Lau P, Pfäfflin F, Müller-Redetzky H, Witzenrath M, Zoller T, Uhrig A, Opitz B, Suttorp N, Kramer TS, Sander LE, Stegemann MS, Kurth F.

Characterization of antimicrobial use and co-infections among hospitalized patients with COVID-19: a prospective observational cohort study.

Infection. 2022 Apr 14:1-12. https://pubmed.ncbi.nlm.nih.gov/35420370/

Westendorp WF, Dames C, Nederkoorn PJ, Meisel A.

Immunodepression, Infections, and Functional Outcome in Ischemic Stroke

Stroke. 2022 Mar 28;STROKEAHA122038867. doi: 10.1161/STROKEAHA.122.038867. https://pubmed.ncbi.nlm.nih.gov/35341322/

Loske J, Röhmel J, Lukassen S, Stricker S, Magalhães VG, Liebig J, Chua RL, Thürmann L, Messingschlager M, Seegebarth A, Timmermann B, Klages S, Ralser M, Sawitzki B, Sander LE, Corman VM, Conrad C, Laudi S, Binder M, Trump S, Eils R, Mall MA, Lehmann I.

Pre-activated antiviral innate immunity in the upper airways controls early SARS-CoV-2 infection in children

Nat Biotechnol. 2022 Mar;40(3):319-324. doi: 10.1038/s41587-021-01037-9. Epub 2021 Aug 18.  https://pubmed.ncbi.nlm.nih.gov/34408314/

Zhu L, Duerr J, Zhou-Suckow Z, Wagner W, Weinheimer O, Salomon J, Leitz D, Konietzke P, Yu H, Ackermann M, Stiller W, Kauczor HU, Mall MA, Wielpütz MO.

µCT to quantify muco-obstructive lung disease and effects of neutrophil elastase knockout in mice

Am J Physiol Lung Cell Mol Physiol. 2022 Mar 1;322(3):L401-L411. doi: 10.1152/ajplung.00341.2021. Epub 2022 Jan 26. https://pubmed.ncbi.nlm.nih.gov/35080183/

Sauerhering L, Kuznetsova I, Kupke A, Meier L, Halwe S, Rohde C, Schmidt J, Morty RE, Danov O, Braun A, Vadász I, Becker S, Herold S.

Cyclosporin A Reveals Potent Antiviral Effects in Preclinical Models of SARS-CoV-2 Infection

Am J Respir Crit Care Med. 2022 Feb 15. doi: 10.1164/rccm.202108-1830LE. Online ahead of print. https://pubmed.ncbi.nlm.nih.gov/35167409/

Kaplonek P, Yao L, Reppe K, Voß F, Kohler T, Ebner F, Schäfer A, Blohm U, Priegue P, Bräutigam M, Pereira CL, Parameswarappa SG, Emmadi M, Ménová P, Witzenrath M, Hammerschmidt S, Hartmann S, Sander LE, Seeberger PH.

A semisynthetic glycoconjugate provides expanded cross-serotype protection against Streptococcus pneumoniae

Vaccine. 2022 Feb 11;40(7):1038-1046.  doi: 10.1016/j.vaccine.2021.12.068.  Epub 2022 Jan 13. pubmed.ncbi.nlm.nih.gov/35033388/

Wygrecka M, Birnhuber A, Seeliger B, Michalick L, Pak O, Schultz AS, Schramm F, Zacharias M, Gorkiewicz G, David S, Welte T, Schmidt JJ, Weissmann N, Schermuly RT, Barreto G, Schaefer L, Markart P, Brack MC, Hippenstiel S, Kurth F, Sander LE, Witzenrath M, Kuebler WM, Kwapiszewska G, Preissner KT.

Altered fibrin clot structure and dysregulated fibrinolysis contribute to thrombosis risk in severe COVID-19

Blood Adv. 2022 Feb 8;6(3):1074-1087.  doi: 10.1182/bloodadvances.2021004816. pubmed.ncbi.nlm.nih.gov/34861681/

Conrad C, Yildiz D, Cleary SJ, Margraf A, Cook L, Schlomann U, Panaretou B, Bowser JL, Karmouty-Quintana H, Li J, Berg NK, Martin SC, Aljohmani A, Moussavi-Harami SF, Wang KM, Tian JJ, Magnen M, Valet C, Qiu L, Singer JP, Eltzschig HK; CAPSys Study Group, Bertrams W, Herold S, Suttorp N, Schmeck B, Ball ZT, Zarbock A, Looney MR, Bartsch JW.

ADAM8 signaling drives neutrophil migration and ARDS severity

JCI Insight. 2022 Feb 8;7(3):e149870. doi: 10.1172/jci.insight.149870.  https://pubmed.ncbi.nlm.nih.gov/35132956/

Georg P, Astaburuaga-García R, Bonaguro L, Brumhard S, Michalick L, Lippert LJ, Kostevc T, Gäbel C, Schneider M, Streitz M, Demichev V, Gemünd I, Barone M, Tober-Lau P, Helbig ET, Hillus D, Petrov L, Stein J, Dey HP, Paclik D, Iwert C, Mülleder M, Aulakh SK, Djudjaj S, Bülow RD, Mei HE, Schulz AR, Thiel A, Hippenstiel S, Saliba AE, Eils R, Lehmann I, Mall MA, Stricker S, Röhmel J, Corman VM, Beule D, Wyler E, Landthaler M, Obermayer B, von Stillfried S, Boor P, Demir M, Wesselmann H, Suttorp N, Uhrig A, Müller-Redetzky H, Nattermann J, Kuebler WM, Meisel C, Ralser M, Schultze JL, Aschenbrenner AC, Thibeault C, Kurth F, Sander LE, Blüthgen N, Sawitzki B; PA-COVID-19 Study Group.

Complement activation induces excessive T cell cytotoxicity in severe COVID-19

Cell. 2022 Feb 3;185(3):493-512.e25.  doi: 10.1016/j.cell.2021.12.040.  Epub 2021 Dec 28. pubmed.ncbi.nlm.nih.gov/35032429/

Bahrs C, Kesselmeier M, Kolditz M, Ewig S, Rohde G, Barten-Neiner G, Rupp J, Witzenrath M, Welte T, Pletz MW; CAPNETZ Study Group.

A longitudinal analysis of pneumococcal vaccine serotypes in pneumonia patients in Germany

Eur Respir J. 2022 Feb 3;59(2):2102432. doi: 10.1183/13993003.02432-2021. Print 2022 Feb. https://pubmed.ncbi.nlm.nih.gov/34824055/

Obermann HL, Lederbogen II, Steele J, Dorna J, Sander LE, Engelhardt K, Bakowsky U, Kaufmann A, Bauer S.

RNA-Cholesterol Nanoparticles Function as Potent Immune Activators via TLR7 and TLR8

Front Immunol. 2022 Jan 21;12:658895. doi: 10.3389/fimmu.2021.658895. eCollection 2021. https://pubmed.ncbi.nlm.nih.gov/35126343/

Kühnapfel A, Horn K, Klotz U, Kiehntopf M, Rosolowski M, Loeffler M, Ahnert P, Suttorp N, Witzenrath M, Scholz M.

Genetic Regulation of Cytokine Response in Patients with Acute Community-Acquired Pneumonia.

Genes (Basel). 2022 Jan 6;13(1):111. https://pubmed.ncbi.nlm.nih.gov/35052452/

Wienhold SM, Brack MC, Nouailles G, Krishnamoorthy G, Korf IHE, Seitz C, Wienecke S, Dietert K, Gurtner C, Kershaw O, Gruber AD, Ross A, Ziehr H, Rohde M, Neudecker J, Lienau J, Suttorp N, Hippenstiel S, Hocke AC, Rohde C, Witzenrath M.

Preclinical Assessment of Bacteriophage Therapy against Experimental Acinetobacter baumannii Lung Infection.

Viruses. 2021 Dec 24;14(1):33. https://pubmed.ncbi.nlm.nih.gov/35062236/

Letsiou E, Teixeira Alves LG, Felten M, Mitchell TJ, Müller-Redetzky HC, Dudek SM, Witzenrath M.

Neutrophil-Derived Extracellular Vesicles Activate Platelets after Pneumolysin Exposure.

Cells. 2021;10(12):3581. https://pubmed.ncbi.nlm.nih.gov/34944089/

Wee BA, Alves J, Lindsay DSJ, Klatt AB, Sargison FA, Cameron RL, Pickering A, Gorzynski J, Corander J, Marttinen P, Opitz B, Smith AJ, Fitzgerald JR.

Population analysis of Legionella pneumophila reveals a basis for resistance to complement-mediated killing

Nat Commun. 2021 Dec 9;12(1):7165. doi: 10.1038/s41467-021-27478-z. https://pubmed.ncbi.nlm.nih.gov/34887398/

Metzger MI, Graeber SY, Stahl M, Sommerburg O, Mall MA, Dalpke AH, Boutin S.

A Volatile and Dynamic Longitudinal Microbiome Is Associated With Less Reduction in Lung Function in Adolescents With Cystic Fibrosis

Front Cell Infect Microbiol. 2021 Dec 6;11:763121. doi: 10.3389/fcimb.2021.763121. eCollection 2021. https://pubmed.ncbi.nlm.nih.gov/34938669/

Trimpert J, Adler JM, Eschke K, Abdelgawad A, Firsching TC, Ebert N, Thao TTN, Gruber AD, Thiel V, Osterrieder N, Kunec D.

Live attenuated virus vaccine protects against SARS-CoV-2 variants of concern B.1.1.7 (Alpha) and B.1.351 (Beta).

Sci Adv. 2021 Dec 3;7(49):eabk0172. doi: 10.1126/sciadv.abk0172. Epub 2021 Dec 1. PMID: 34851677; PMCID: PMC8635430. pubmed.ncbi.nlm.nih.gov/34851677/

Gruber AD, Firsching TC, Trimpert J, Dietert K.

Hamster models of COVID-19 pneumonia reviewed: How human can they be?

Vet Pathol. 2021 Dec 2:3009858211057197. doi: 10.1177/03009858211057197. Epub ahead of print. PMID: 34856819. pubmed.ncbi.nlm.nih.gov/34856819/

Steinbeis F, Thibeault C, Doellinger F, Ring RM, Mittermaier M, Ruwwe-Glösenkamp C, Alius F, Knape P, Meyer HJ, Lippert LJ, Helbig ET, Grund D, Temmesfeld-Wollbrück B, Suttorp N, Sander LE, Kurth F, Penzkofer T, Witzenrath M, Zoller T.

Severity of respiratory failure and computed chest tomography in acute COVID-19 correlates with pulmonary function and respiratory symptoms after infection with SARS-CoV-2: An observational longitudinal study over 12 months.

Respir Med. 2021 Dec 1;191:106709. doi: 10.1016/j.rmed.2021.106709. Epub ahead of print. PMID: 34871947; PMCID: PMC8632363. pubmed.ncbi.nlm.nih.gov/34871947/

Wendisch D, Dietrich O, Mari T, von Stillfried S, Ibarra IL, Mittermaier M, Mache C, Chua RL, Knoll R, Timm S, Brumhard S, Krammer T, Zauber H, Hiller AL, Pascual-Reguant A, Mothes R, Bülow RD, Schulze J, Leipold AM, Djudjaj S, Erhard F, Geffers R, Pott F, Kazmierski J, Radke J, Pergantis P, Baßler K, Conrad C, Aschenbrenner AC, Sawitzki B, Landthaler M, Wyler E, Horst D; Deutsche COVID-19 OMICS Initiative (DeCOI), Hippenstiel S, Hocke A, Heppner FL, Uhrig A, Garcia C, Machleidt F, Herold S, Elezkurtaj S, Thibeault C, Witzenrath M, Cochain C, Suttorp N, Drosten C, Goffinet C, Kurth F, Schultze JL, Radbruch H, Ochs M, Eils R, Müller-Redetzky H, Hauser AE, Luecken MD, Theis FJ, Conrad C, Wolff T, Boor P, Selbach M, Saliba AE, Sander LE.

SARS-CoV-2 infection triggers profibrotic macrophage responses and lung fibrosis.

Cell. 2021 Nov 27:S0092-8674(21)01383-0. doi: 10.1016/j.cell.2021.11.033. Epub ahead of print. PMID: 34914922. pubmed.ncbi.nlm.nih.gov/34914922/

Trimpert J, Herwig S, Stein J, Vladimirova D, Adler JM, Abdelgawad A, Firsching TC, Thoma T, Sehouli J, Osterrieder K, Gruber AD, Sawitzki B, Sander LE, Cichon G.

Deciphering the Role of Humoral and Cellular Immune Responses in Different COVID-19 Vaccines-A Comparison of Vaccine Candidate Genes in Roborovski Dwarf Hamsters.

Viruses. 2021 Nov 16;13(11):2290. doi: 10.3390/v13112290. PMID: 34835096; PMCID: PMC8625836. pubmed.ncbi.nlm.nih.gov/34835096/

Al-Karmalawy AA, Soltane R, Abo Elmaaty A, Tantawy MA, Antar SA, Yahya G, Chrouda A, Pashameah RA, Mustafa M, Abu Mraheil M, Mostafa A.

Coronavirus Disease (COVID-19) Control between Drug Repurposing and Vaccination: A Comprehensive Overview

Vaccines (Basel). 2021 Nov 12;9(11):1317. doi: 10.3390/vaccines9111317. https://pubmed.ncbi.nlm.nih.gov/34835248/

Mahmoud W, Perniss A, Poharkar K, Soultanova A, Pfeil U, Hoek A, Bhushan S, Hain T, Gärtner U, Kummer W.

CXCL13 is expressed in a subpopulation of neuroendocrine cells in the murine trachea and lung.

Cell Tissue Res. 2022 Oct;390(1):35-49. doi: 10.1007/s00441-021-03552-2. pubmed.ncbi.nlm.nih.gov/34762185/

Hey J, Paulsen M, Toth R, Weichenhan D, Butz S, Schatterny J, Liebers R, Lutsik P, Plass C, Mall MA.

Epigenetic reprogramming of airway macrophages promotes polarization and inflammation in muco-obstructive lung disease

Nat Commun. 2021 Nov 11;12(1):6520.  doi: 10.1038/s41467-021-26777-9. pubmed.ncbi.nlm.nih.gov/34764283/

Mösbauer K, Fritsch VN, Adrian L, Bernhardt J, Gruhlke MCH, Slusarenko AJ, Niemeyer D, Antelmann H.

The Effect of Allicin on the Proteome of SARS-CoV-2 Infected Calu-3 Cells.

Front Microbiol. 2021 Oct 28;12:746795. doi: 10.3389/fmicb.2021.746795. PMID: 34777295; PMCID: PMC8581659. pubmed.ncbi.nlm.nih.gov/34777295/

Witkowski M, Tizian C, Ferreira-Gomes M, Niemeyer D, Jones TC, Heinrich F, Frischbutter S, Angermair S, Hohnstein T, Mattiola I, Nawrath P, Mc Ewen S, Zocche S, Viviano E, Heinz GA, Maurer M, Kölsch U, Chua RL, Aschman T, Meisel C, Radke J, Sawitzki B, Roehmel J, Allers K, Moos V, Schneider T, Hanitsch L, Mall MA, Conrad C, Radbruch H, Duerr CU, Trapani JA, Marcenaro E, Kallinich T, Corman VM, Kurth F, Sander LE, Drosten C, Treskatsch S, Durek P, Kruglov A, Radbruch A, Mashreghi MF, Diefenbach A.

Untimely TGFβ responses in COVID-19 limit antiviral functions of NK cells

Nature. 2021 Oct 25. doi: 10.1038/s41586-021-04142-6. Epub ahead of print. PMID: 34695836. pubmed.ncbi.nlm.nih.gov/34695836/

Van Loi V, Busche T, Fritsch VN, Weise C, Gruhlke MCH, Slusarenko AJ, Kalinowski J, Antelmann H.

The two-Cys-type TetR repressor GbaA confers resistance under disulfide and electrophile stress in Staphylococcus aureus.

Free Radic Biol Med. 2021 Oct 19;177:120-131. doi: 10.1016/j.freeradbiomed.2021.10.024. Epub ahead of print. PMID: 34678418. pubmed.ncbi.nlm.nih.gov/34678418/

Schulze J, Mache C, Balázs A, Frey D, Niemeyer D, Olze H, Dommerich S, Drosten C, Hocke AC, Mall MA, Hippenstiel S, Wolff T.

Analysis of SARS-CoV-2 replication in explant cultures of the human upper respiratory tract reveals broad tissue tropism of wild-type and B.1.1.7 variant viruses.

J Infect Dis. 2021 Oct 15:jiab523. doi: 10.1093/infdis/jiab523. Epub ahead of print. PMID: 34651643; PMCID: PMC8524635. pubmed.ncbi.nlm.nih.gov/34651643/

Ehrlich K, Wilhelm J, Markart P, Weisser H, Wolff JC, Bein G, Pak O, Barreto G, Weissmann N, Schramm F, Seeger W, Schaefer L, Kuebler WM, Wygrecka M; and members of the CAPNETZ Study Group.

Sex-specific differences in plasma levels of FXII, HK, and FXIIa-C1-esterase inhibitor complexes in community-acquired pneumonia.

Am J Physiol Lung Cell Mol Physiol. 2021 Oct 1;321(4):L764-L774. doi: 10.1152/ajplung.00162.2021. Epub 2021 Jul 28. PMID: 34318685. pubmed.ncbi.nlm.nih.gov/34318685/

Brox R, Achenbach S, Hackstein H.

Detection of SARS-CoV-2-independent immunoregulatory activity of COVID-19 convalescent plasma.

Transfusion. 2021 Sep 21. doi: 10.1111/trf.16685. Epub ahead of print. PMID: 34546583. pubmed.ncbi.nlm.nih.gov/34546583/

Shaban MS, Müller C, Mayr-Buro C, Weiser H, Meier-Soelch J, Albert BV, Weber A, Linne U, Hain T, Babayev I, Karl N, Hofmann N, Becker S, Herold S, Schmitz ML, Ziebuhr J, Kracht M.

Multi-level inhibition of coronavirus replication by chemical ER stress.

Nat Commun. 2021 Sep 20;12(1):5536. doi: 10.1038/s41467-021-25551-1. PMID: 34545074; PMCID: PMC8452654. pubmed.ncbi.nlm.nih.gov/34545074/

Mermer P, Strotmann J, Kummer W, Paddenberg R.

Olfactory receptor Olfr78 (prostate-specific G protein-coupled receptor PSGR) expression in arterioles supplying skeletal and cardiac muscles and in arterioles feeding some murine organs

Histochem Cell Biol. 2021 Dec;156(6):539-553. doi: 10.1007/s00418-021-02032-6. Epub 2021 Sep 20. https://pubmed.ncbi.nlm.nih.gov/34545457/

Pusch L, Brox R, Scheuer K, Yokosawa T, Wu M, Zubiri BA, Spiecker E, Jandt KD, Fischer D, Hackstein H.

Distinct endocytosis and immune activation of poly(lactic-co-glycolic) acid nanoparticles prepared by single- and double-emulsion evaporation.

Nanomedicine (Lond). 2021 Oct;16(23):2075-2094. doi: 10.2217/nnm-2021-0022. Epub 2021 Sep 15. PMID: 34523349. pubmed.ncbi.nlm.nih.gov/34523349/

Lee S, Yu Y, Trimpert J, Benthani F, Mairhofer M, Richter-Pechanska P, Wyler E, Belenki D, Kaltenbrunner S, Pammer M, Kausche L, Firsching TC, Dietert K, Schotsaert M, Martínez-Romero C, Singh G, Kunz S, Niemeyer D, Ghanem R, Salzer HJF, Paar C, Mülleder M, Uccellini M, Michaelis EG, Khan A, Lau A, Schönlein M, Habringer A, Tomasits J, Adler JM, Kimeswenger S, Gruber AD, Hoetzenecker W, Steinkellner H, Purfürst B, Motz R, Di Pierro F, Lamprecht B, Osterrieder N, Landthaler M, Drosten C, García-Sastre A, Langer R, Ralser M, Eils R, Reimann M, Fan DNY, Schmitt CA.

Virus-induced senescence is a driver and therapeutic target in COVID-19.

Nature. 2021 Nov;599(7884):283-289. doi: 10.1038/s41586-021-03995-1. Epub 2021 Sep 13. PMID: 34517409. pubmed.ncbi.nlm.nih.gov/34517409/

Herta T, Bhattacharyya A, Rosolowski M, Conrad C, Gurtner C, Gruber AD, Ahnert P, Gutbier B, Frey D, Suttorp N, Hippenstiel S, Zahlten J.

Krueppel-Like Factor 4 Expression in Phagocytes Regulates Early Inflammatory Response and Disease Severity in Pneumococcal Pneumonia.

Front Immunol. 2021 Sep 13;12:726135. doi: 10.3389/fimmu.2021.726135. PMID: 34589087; PMCID: PMC8473698. pubmed.ncbi.nlm.nih.gov/34589087/

Lee S, Yu Y, Trimpert J, Benthani F, Mairhofer M, Richter-Pechanska P, Wyler E, Belenki D, Kaltenbrunner S, Pammer M, Kausche L, Firsching TC, Dietert K, Schotsaert M, Martínez-Romero C, Singh G, Kunz S, Niemeyer D, Ghanem R, Salzer HJF, Paar C, Mülleder M, Uccellini M, Michaelis EG, Khan A, Lau A, Schönlein M, Habringer A, Tomasits J, Adler JM, Kimeswenger S, Gruber AD, Hoetzenecker W, Steinkellner H, Purfürst B, Motz R, Di Pierro F, Lamprecht B, Osterrieder N, Landthaler M, Drosten C, García-Sastre A, Langer R, Ralser M, Eils R, Reimann M, Fan DNY, Schmitt CA.

Virus-induced senescence is driver and therapeutic target in COVID-19.

Nature. 2021 Sep 13. doi: 10.1038/s41586-021-03995-1. Epub ahead of print. PMID: 34517409. pubmed.ncbi.nlm.nih.gov/34517409/

Schroeder S, Mache C, Kleine-Weber H, Corman VM, Muth D, Richter A, Fatykhova D, Memish ZA, Stanifer ML, Boulant S, Gultom M, Dijkman R, Eggeling S, Hocke A, Hippenstiel S, Thiel V, Pöhlmann S, Wolff T, Müller MA, Drosten C.

Functional comparison of MERS-coronavirus lineages reveals increased replicative fitness of the recombinant lineage 5.

Nat Commun. 2021 Sep 7;12(1):5324. doi: 10.1038/s41467-021-25519-1. PMID: 34493730. pubmed.ncbi.nlm.nih.gov/34493730/

Weiner J, Suwalski P, Holtgrewe M, Rakitko A, Thibeault C, Müller M, Patriki D, Quedenau C, Krüger U, Ilinsky V, Popov I, Balnis J, Jaitovich A, Helbig ET, Lippert LJ, Stubbemann P, Real LM, Macías J, Pineda JA, Fernandez-Fuertes M, Wang X, Karadeniz Z, Saccomanno J, Doehn JM, Hübner RH, Hinzmann B, Salvo M, Blueher A, Siemann S, Jurisic S, Beer JH, Rutishauser J, Wiggli B, Schmid H, Danninger K, Binder R, Corman VM, Mühlemann B, Arjun Arkal R, Fragiadakis GK, Mick E, Comet C, Calfee CS, Erle DJ, Hendrickson CM, Kangelaris KN, Krummel MF, Woodruff PG, Langelier CR, Venkataramani U, García F, Zyla J, Drosten C, Alice B, Jones TC, Suttorp N, Witzenrath M, Hippenstiel S, Zemojtel T, Skurk C, Poller W, Borodina T, Pa-Covid SG, Ripke S, Sander LE, Beule D, Landmesser U, Guettouche T, Kurth F, Heidecker B.

Increased risk of severe clinical course of COVID-19 in carriers of HLA-C*04:01

EClinicalMedicine. 2021 Oct;40:101099. doi: 10.1016/j.eclinm.2021.101099. Epub 2021 Sep 2. PMID: 34490415; PMCID: PMC8410317. pubmed.ncbi.nlm.nih.gov/34490415/

Loyal L, Braun J, Henze L, Kruse B, Dingeldey M, Reimer U, Kern F, Schwarz T, Mangold M, Unger C, Dörfler F, Kadler S, Rosowski J, Gürcan K, Uyar-Aydin Z, Frentsch M, Kurth F, Schnatbaum K, Eckey M, Hippenstiel S, Hocke A, Müller MA, Sawitzki B, Miltenyi S, Paul F, Mall MA, Wenschuh H, Voigt S, Drosten C, Lauster R, Lachman N, Sander LE, Corman VM, Röhmel J, Meyer-Arndt L, Thiel A, Giesecke-Thiel C.

Cross-reactive CD4+ T cells enhance SARS-CoV-2 immune responses upon infection and vaccination.

Science. 2021 Aug 31:eabh1823. doi: 10.1126/science.abh1823. Epub ahead of print. PMID: 34465633. pubmed.ncbi.nlm.nih.gov/34465633/

Linzner N, Antelmann H.

The Antimicrobial Activity of the AGXX® Surface Coating Requires a Small Particle Size to Efficiently Kill Staphylococcus aureus.

Front Microbiol. 2021 Aug 12;12:731564. doi: 10.3389/fmicb.2021.731564. PMID: 34456898; PMCID: PMC8387631. pubmed.ncbi.nlm.nih.gov/34456898/

Hillus D, Schwarz T, Tober-Lau P, Vanshylla K, Hastor H, Thibeault C, Jentzsch S, Helbig ET, Lippert LJ, Tscheak P, Schmidt ML, Riege J, Solarek A, von Kalle C, Dang-Heine C, Gruell H, Kopankiewicz P, Suttorp N, Drosten C, Bias H, Seybold J; EICOV/COVIM Study Group, Klein F, Kurth F, Corman VM, Sander LE.

Safety, reactogenicity, and immunogenicity of homologous and heterologous prime-boost immunisation with ChAdOx1 nCoV-19 and BNT162b2: a prospective cohort study.

Lancet Respir Med. 2021 Aug 12:S2213-2600(21)00357-X. doi: 10.1016/S2213-2600(21)00357-X. Epub ahead of print. PMID: 34391547; PMCID: PMC8360702. pubmed.ncbi.nlm.nih.gov/34391547/

Nouailles G, Wyler E, Pennitz P, Postmus D, Vladimirova D, Kazmierski J, Pott F, Dietert K, Muelleder M, Farztdinov V, Obermayer B, Wienhold SM, Andreotti S, Hoefler T, Sawitzki B, Drosten C, Sander LE, Suttorp N, Ralser M, Beule D, Gruber AD, Goffinet C, Landthaler M, Trimpert J, Witzenrath M.

Temporal omics analysis in Syrian hamsters unravel cellular effector responses to moderate COVID-19

Nat Commun. 2021 Aug 11;12(1):4869. doi: 10.1038/s41467-021-25030-7. https://pubmed.ncbi.nlm.nih.gov/34381043/

Trimpert J, Dietert K, Firsching TC, Ebert N, Thi Nhu Thao T, Vladimirova D, Kaufer S, Labroussaa F, Abdelgawad A, Conradie A, Höfler T, Adler JM, Bertzbach LD, Jores J, Gruber AD, Thiel V, Osterrieder N, Kunec D.

Development of safe and highly protective live-attenuated SARS-CoV-2 vaccine candidates by genome recoding

 Cell Rep. 2021 Aug 3;36(5):109493. doi: 10.1016/j.celrep.2021.109493. Epub 2021 Jul 20. https://pubmed.ncbi.nlm.nih.gov/34320400/

Paulina Kaplonek, Ling Yao, Katrin Reppe, Franziska Voß, Thomas Kohler, Friederike Ebner, Alexander Schäfer, Ulrike Blohm, Patricia Priegue, Maria Bräutigam, Claney L. Pereira, Sharavathi G. Parameswarappa, Madhu Emmadi, Petra Ménová, Martin Witzenrath, Sven Hammerschmidt, Susanne Hartmann, Leif E. Sander, Peter H. Seeberger

A semisynthetic glycoconjugate provides expanded cross-serotype protection against Streptococcus pneumoniae .

bioRxiv 2021.07.29.454378; doi: doi.org/10.1101/2021.07.29.454378www.biorxiv.org/content/10.1101/2021.07.29.454378v1

Engelmann TA, Knudsen L, Leitz DHW, Duerr J, Beers MF, Mall MA, Ochs M.

Linking Fibrotic Remodeling and Ultrastructural Alterations of Alveolar Epithelial Cells after Deletion of Nedd4-2.

Int J Mol Sci. 2021 Jul 16;22(14):7607. doi: 10.3390/ijms22147607. PMID: 34299227; PMCID: PMC8306112. pubmed.ncbi.nlm.nih.gov/34299227/

Gadalla MR, Morrison E, Serebryakova MV, Han X, Wolff T, Freund C, Kordyukova L, Veit M.

NS1-mediated upregulation of ZDHHC22 acyltransferase in influenza a virus infected cells

Cell Microbiol. 2021 Jun;23(6):e13322. doi: 10.1111/cmi.13322. Epub 2021 Mar 9. https://pubmed.ncbi.nlm.nih.gov/33629465/

Gassen NC, Papies J, Bajaj T, Emanuel J, Dethloff F, Chua RL, Trimpert J, Heinemann N, Niemeyer C, Weege F, Hönzke K, Aschman T, Heinz DE, Weckmann K, Ebert T, Zellner A, Lennarz M, Wyler E, Schroeder S, Richter A, Niemeyer D, Hoffmann K, Meyer TF, Heppner FL, Corman VM, Landthaler M, Hocke AC, Morkel M, Osterrieder N, Conrad C, Eils R, Radbruch H, Giavalisco P, Drosten C, Müller MA.

SARS-CoV-2-mediated dysregulation of metabolism and autophagy uncovers host-targeting antivirals.

Nat Commun. 2021 Jun 21;12(1):3818. doi: 10.1038/s41467-021-24007-w. PMID: 34155207; PMCID: PMC8217552. pubmed.ncbi.nlm.nih.gov/34155207/

Jagdmann S, Berchtold D, Gutbier B, Witzenrath M, Meisel A, Meisel C, Dames C

Efficacy and safety of intratracheal IFN-γ treatment to reverse stroke-induced susceptibility to pulmonary bacterial infections

J Neuroimmunol. 2021 Jun 15;355:577568. doi: 10.1016/j.jneuroim.2021.577568. Epub 2021 Apr 3. PMID: 33862420. pubmed.ncbi.nlm.nih.gov/33862420/

Demichev V, Tober-Lau P, Lemke O, Nazarenko T, Thibeault C, Whitwell H, Röhl A, Freiwald A, Szyrwiel L, Ludwig D, Correia-Melo C, Aulakh SK, Helbig ET, Stubbemann P, Lippert LJ, Grüning NM, Blyuss O, Vernardis S, White M, Messner CB, Joannidis M, Sonnweber T, Klein SJ, Pizzini A, Wohlfarter Y, Sahanic S, Hilbe R, Schaefer B, Wagner S, Mittermaier M, Machleidt F, Garcia C, Ruwwe-Glösenkamp C, Lingscheid T, Bosquillon de Jarcy L, Stegemann MS, Pfeiffer M, Jürgens L, Denker S, Zickler D, Enghard P, Zelezniak A, Campbell A, Hayward C, Porteous DJ, Marioni RE, Uhrig A, Müller-Redetzky H, Zoller H, Löffler-Ragg J, Keller MA, Tancevski I, Timms JF, Zaikin A, Hippenstiel S, Ramharter M, Witzenrath M, Suttorp N, Lilley K, Mülleder M, Sander LE; PA-COVID-19 Study group, Ralser M, Kurth F.

A time-resolved proteomic and prognostic map of COVID-19

Cell Syst. 2021 Jun 14:S2405-4712(21)00160-5. doi: 10.1016/j.cels.2021.05.005. Epub ahead of print. PMID: 34139154; PMCID: PMC8201874. pubmed.ncbi.nlm.nih.gov/34139154/

Leitz DHW, Duerr J, Mulugeta S, Seyhan Agircan A, Zimmermann S, Kawabe H, Dalpke AH, Beers MF, Mall MA.

Congenital Deletion of Nedd4-2 in Lung Epithelial Cells Causes Progressive Alveolitis and Pulmonary Fibrosis in Neonatal Mice.

Int J Mol Sci. 2021 Jun 7;22(11):6146. doi: 10.3390/ijms22116146. PMID: 34200296; PMCID: PMC8201155. pubmed.ncbi.nlm.nih.gov/34200296/

Hagner M, Albrecht M, Guerra M, Braubach P, Halle O, Zhou-Suckow Z, Butz S, Jonigk D, Hansen G, Schultz C, Dittrich AM, Mall MA.

IL-17A from innate and adaptive lymphocytes contributes to inflammation and damage in cystic fibrosis lung disease

Eur Respir J. 2021 Jun 4;57(6):1900716. doi: 10.1183/13993003.00716-2019. PMID: 33303549. pubmed.ncbi.nlm.nih.gov/33303549/

Witzenrath M, Kuebler WM.

The CypA-netics of Ventilator-Induced Lung Injury

Am J Respir Crit Care Med. 2021 May 25. doi: 10.1164/rccm.202104-0919ED. Epub ahead of print. PMID: 34033522. pubmed.ncbi.nlm.nih.gov/34033522/

Jung AL, Schmeck B, Wiegand M, Bedenbender K, Benedikter BJ.

The clinical role of host and bacterial-derived extracellular vesicles in pneumonia

Adv Drug Deliv Rev. 2021 May 19:S0169-409X(21)00185-X. doi: 10.1016/j.addr.2021.05.021. Epub ahead of print. PMID: 34022269. pubmed.ncbi.nlm.nih.gov/34022269/

Schmerer N, Schulte LN.

Long noncoding RNAs in bacterial infection

Wiley Interdiscip Rev RNA. 2021 May 14:e1664. doi: 10.1002/wrna.1664. Epub ahead of print. PMID: 33989449. pubmed.ncbi.nlm.nih.gov/33989449/

Birnhuber A, Fliesser E, Gorkiewicz G, Zacharias M, Seeliger B, David S, Welte T, Schmidt J, Olschewski H, Wygrecka M, Kwapiszewska G.

Between inflammation and thrombosis - endothelial cells in COVID-19

Eur Respir J. 2021 May 13:2100377. doi: 10.1183/13993003.00377-2021. Epub ahead of print. PMID: 33958433; PMCID: PMC8112008. pubmed.ncbi.nlm.nih.gov/33958433/

McKelvey MC, Brown R, Ryan S, Mall MA, Weldon S, Taggart CC.

Proteases, Mucus, and Mucosal Immunity in Chronic Lung Disease

Int J Mol Sci. 2021 May 9;22(9):5018. doi: 10.3390/ijms22095018. PMID: 34065111; PMCID: PMC8125985. pubmed.ncbi.nlm.nih.gov/34065111/

Letsiou E, Teixeira Alves LG, Fatykhova D, Felten M, Mitchell TJ, Müller-Redetzky HC, Hocke AC, Witzenrath M.

Microvesicles released from pneumolysin-stimulated lung epithelial cells carry mitochondrial cargo and suppress neutrophil oxidative burst

Sci Rep. 2021 May 5;11(1):9529. doi: 10.1038/s41598-021-88897-y. PMID: 33953279; PMCID: PMC8100145. pubmed.ncbi.nlm.nih.gov/33953279/

Hadzibegovic S, Lena A, Churchill TW, Ho JE, Potthoff S, Denecke C, Rösnick L, Heim KM, Kleinschmidt M, Sander LE, Witzenrath M, Suttorp N, Krannich A, Porthun J, Friede T, Butler J, Wilkenshoff U, Pieske B, Landmesser U, Anker SD, Lewis GD, Tschöpe C, Anker MS.

Heart failure with preserved ejection fraction according to the HFA-PEFF score in COVID-19 patients: clinical correlates and echocardiographic findings

Eur J Heart Fail. 2021 May 1:10.1002/ejhf.2210. doi: 10.1002/ejhf.2210. Epub ahead of print. PMID: 33932255; PMCID: PMC8239668. pubmed.ncbi.nlm.nih.gov/33932255/

Bertrams W, Lindhauer NS, Rieke MC, Paas A, Hoffmann K, Greene B, Visekruna A, Vilcinskas A, Seidel K, Schmeck B.

Tribolium castaneum defensin 1 kills Moraxella catarrhalis in an in vitro infection model but does not harm commensal bacteria

Virulence. 2021 Dec;12(1):1003-1010. doi: 10.1080/21505594.2021.1908741. PMID: 33843461; PMCID: PMC8043168. pubmed.ncbi.nlm.nih.gov/33843461/

Messner CB, Demichev V, Bloomfield N, Yu JSL, White M, Kreidl M, Egger AS, Freiwald A, Ivosev G, Wasim F, Zelezniak A, Jürgens L, Suttorp N, Sander LE, Kurth F, Lilley KS, Mülleder M, Tate S, Ralser M.

Ultra-fast proteomics with Scanning SWATH.

Nat Biotechnol. 2021 Mar 25. doi: 10.1038/s41587-021-00860-4. Online ahead of print. PMID: 33767396. pubmed.ncbi.nlm.nih.gov/33767396/

Doehn JM, Tabeling C, Biesen R, Saccomanno J, Madlung E, Pappe E, Gabriel F, Kurth F, Meisel C, Corman VM, Hanitsch LG, Treskatsch S, Heim K, Stegemann MS, Ruwwe-Glösenkamp C, Müller-Redetzky HC, Uhrig A, Somasundaram R, Spies C, von Bernuth H, Hofmann J, Drosten C, Suttorp N, Witzenrath M, Sander LE, Hübner RH.

CD169/SIGLEC1 is expressed on circulating monocytes in COVID-19 and expression levels are associated with disease severity

Infection. 2021 Apr 6:1–6. doi: 10.1007/s15010-021-01606-9. Epub ahead of print. PMID: 33825125; PMCID: PMC8023546. pubmed.ncbi.nlm.nih.gov/33825125/

Bertrams W, Griss K, Han M, Seidel K, Hippenstiel S, Suttorp N, Finkernagel F, Wilhelm J, Vogelmeier CF, Schmeck B.

Transcriptional analysis identifies potential biomarkers and molecular regulators in acute malaria infection

Life Sci. 2021 Apr 1;270:119158. doi: 10.1016/j.lfs.2021.119158. Epub 2021 Feb 2. PMID: 33545200. pubmed.ncbi.nlm.nih.gov/33545200/

Cunningham S, Hackstein H.

Rapid generation of monocyte-derived antigen-presenting cells with dendritic cell-like properties.

Transfusion. 2021 Jun;61(6):1845-1855. doi: 10.1111/trf.16385. Epub 2021 Mar 30. PMID: 33786883. pubmed.ncbi.nlm.nih.gov/33786883/

Adhikary PP, Ul Ain Q, Hocke AC, Hedtrich S.

COVID-19 highlights the model dilemma in biomedical research

Nat Rev Mater. 2021 Mar 17:1-3. doi: 10.1038/s41578-021-00305-z. Epub ahead of print. PMID: 33747552; PMCID: PMC7967778. pubmed.ncbi.nlm.nih.gov/33747552/

Perniss A, Schmidt P, Soultanova A, Papadakis T, Dahlke K, Voigt A, Schütz B, Kummer W, Deckmann K.

Development of epithelial cholinergic chemosensory cells of the urethra and trachea of mice

Cell Tissue Res. 2021 Feb 22. doi: 10.1007/s00441-021-03424-9. Epub ahead of print. PMID: 33616728. pubmed.ncbi.nlm.nih.gov/33616728/

Brown R, Small DM, Doherty DF, Holsinger L, Booth R, Williams R, Ingram RJ, Elborn JS, Mall MA, Taggart CC, Weldon S.

Therapeutic Inhibition of Cathepsin S Reduces Inflammation and Mucus Plugging in Adult βENaC-Tg Mice.

Mediators Inflamm. 2021 Mar 19;2021:6682657. doi: 10.1155/2021/6682657. PMID: 33828414; PMCID: PMC8004367.

pubmed.ncbi.nlm.nih.gov/33828414/

Leister H, Luu M, Staudenraus D, Lopez Krol A, Mollenkopf H, Sharma A, Schmerer N, Schulte LN, Bertrams W, Schmeck B, Bosmann M, Steinhoff U, Visekruna A.

Pro- and anti-tumorigenic capacity of immunoproteasomes in shaping the tumor microenvironment

Cancer Immunol Res. 2021 Mar 11. doi: 10.1158/2326-6066.CIR-20-0492. Epub ahead of print. PMID: 33707310. pubmed.ncbi.nlm.nih.gov/33707310/

Vazquez-Armendariz AI, Herold S.

From Clones to Buds and Branches. The Use of Lung Organoids to Mod Branching Morphogenesis Ex Vivo

Front Cell Dev Biol. 2021 Mar 4;9:631579. doi: 10.3389/fcell.2021.631579. PMID: 33748115; PMCID: PMC7969706. pubmed.ncbi.nlm.nih.gov/33748115/

Tabeling C, Wienhold SM, Birnhuber A, Brack MC, Nouailles G, Kershaw O, Firsching TC, Gruber AD, Lienau J, Marsh LM, Olschewski A, Kwapiszewska G, Witzenrath M.

Pulmonary fibrosis in Fra-2 transgenic mice is associated with decreased numbers of alveolar macrophages and increased susceptibility to pneumococcal pneumonia

Am J Physiol Lung Cell Mol Physiol. 2021 Mar 3. doi: 10.1152/ajplung.00505.2020. Epub ahead of print. PMID: 33655757. pubmed.ncbi.nlm.nih.gov/33655757/

Gonzales J, Chakraborty T, Romero M, Mraheil MA, Kutlar A, Pace B, Lucas R.

Streptococcus pneumoniae and Its Virulence Factors H2O2 and Pneumolysin Are Potent Mediators of the Acute Chest Syndrome in Sickle Cell Disease

Toxins (Basel). 2021 Feb 17;13(2):157. doi: 10.3390/toxins13020157. https://pubmed.ncbi.nlm.nih.gov/33671422/

Linden G, Janga H, Franz M, Nist A, Stiewe T, Schmeck B, Vázquez O, Schulte LN.

Efficient antisense inhibition reveals microRNA-155 to restrain a late-myeloid inflammatory programme in primary human phagocytes

RNA Biol. 2021 Feb 23:1-15. doi: 10.1080/15476286.2021.1885209. Epub ahead of print. PMID: 33622174. pubmed.ncbi.nlm.nih.gov/33622174/

Bhattacharyya A, Herta T, Conrad C, Frey D, García P, Suttorp N, Hippenstiel S, Zahlten J.

Induction of Krüppel-Like Factor 4 Mediates Polymorphonuclear Neutrophil Activation in Streptococcus pneumoniae Infection.

Front Microbiol. 2021 Feb 3;11:582070. doi: 10.3389/fmicb.2020.582070. PMID: 33613460; PMCID: PMC7887292. pubmed.ncbi.nlm.nih.gov/33613460/

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Photon arrival time tagging with many channels, sub-nanosecond deadtime, very high throughput, and fiber optic remote synchronization

Rev Sci Instrum. 2020 Jan 1;91(1):013108

McKelvey MC, Weldon S, McAuley DF, Mall MA, Taggart CC

Targeting proteases in cystic fibrosis lung disease: Paradigms, progress, and potential.

Am J Respir Crit Care Med. 2020 Jan 15;201(2):141-147.

Bertrams W, Griss K, Han M, Seidel K, Klemmer A, Sittka-Stark A, Hippenstiel S, Suttorp N, Finkernagel F, Wilhelm J, Greulich T, Vogelmeier C, Vera J, Schmeck B

Transcriptional analysis identifies potential biomarkers and molecular regulators in pneumonia and COPD exacerbation.

Sci Rep. 2020 Jan 14;10(1):241.

Bell SC, Mall MA, Gutierrez H, Macek M, Madge S, Davies JC, Burgel PR, Tullis E, Castanos C, Castellani C, Byrnes CA, Cathcart F, Chotirmall SH, Cosgriff R, Eichler I, Fajac I, Goss CH, Drevinek P, Farrell PM, Gravelle AM, Havermans T, Mayer-Hamblett N, Kashirskaya N, Kerem E, Mathew JL, McKone EF, Naehrlich L, Nasr SZ, Oates GR, O'Neill C, Pypops U, Raraigh KS, Rowe SM, Southern KW, Sivam S, Stephenson AL, Zampoli M, Ratjen F

The future of cystic fibrosis care: A global perspective.

Lancet Respir Med. 2020 Jan;8(1):65-124.

Erickson NA, Gruber AD, Mundhenk L.

The Family of Chloride Channel Regulator, Calcium-activated Proteins in the Feline Respiratory Tract: A Comparative Perspective on Airway Diseases in Man and Animal Models

J Comp Pathol. 2020 Jan;174:39-53. doi: 10.1016/j.jcpa.2019.10.193.

Mall MA, Mayer-Hamblett N, Rowe SM

Cystic fibrosis: Emergence of highly effective targeted therapeutics and potential clinical implications.

Am J Respir Crit Care Med. 2019 Dec 20

Lückel C, Picard F, Raifer H, Campos Carrascosa L, Guralnik A, Zhang Y, Klein M, Bittner S, Steffen F, Moos S, Marini F, Gloury R, Kurschus FC, Chao YY, Bertrams W, Sexl V, Schmeck B, Bonetti L, Grusdat M, Lohoff M, Zielinski CE, Zipp F, Kallies A, Brenner D, Berger M, Bopp T, Tackenberg B, Huber M

IL-17+ CD8+ T cell suppression by dimethyl fumarate associates with clinical response in multiple sclerosis.

Nat Commun. 2019 Dec 16;10(1):5722.

Hübner K, Karwelat D, Pietsch E, Beinborn I, Winterberg S, Bedenbender K, Benedikter BJ, Schmeck B, Vollmeister E

NF-κB-mediated inhibition of microRNA-149-5p regulates Chitinase-3-like 1 expression in human airway epithelial cells.

Cell Signal. 2019 Dec 16;67:109498.

Matos ADR, Wunderlich K, Schloer S, Schughart K, Geffers R, Seders M, Witt M, Christersson A, Wiewrodt R, Wiebe K, Barth P, Hocke A, Hippenstiel S, Hönzke K, Dittmer U, Sutter K, Rescher U, Rodionycheva S, Matera N, Ludwig S, Brunotte L.

Antiviral potential of human IFN-α subtypes against influenza A H3N2 infection in human lung explants reveals subtype-specific activities

Emerg Microbes Infect. 2019; 8(1): 1763–1776.

Lindhauer N, Bertrams W, Pöppel A, Herkt C, Wesener A, Hoffmann K, Greene B, van der Linden M, Vilcinskas A, Seidel K, Schmeck B.

Antibacterial activity of a Tribolium castaneum defensin in an in vitro infection model of Streptococcus pneumoniae.

Virulence. 2019 Dec10 (1):902-909

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Fritsch VN, Loi VV, Busche T, Sommer A, Tedin K, Nürnberg DJ, Kalinowski J, Bernhardt J, Fulde M, Antelmann H

The MarR-Type Repressor MhqR Confers Quinone and Antimicrobial Resistance in Staphylococcus aureus

Antioxid Redox Signal. 2019 Dec 1;31(16):1235-1252. doi: 10.1089/ars.2019.7750.

Balazs A, Mall MA

Mucus obstruction and inflammation in early cystic fibrosis lung disease: Emerging role of the IL-1 signaling pathway.

Pediatr Pulmonol. 2019 Nov;54 Suppl 3:S5-S12.

 

Jung AL, Møller Jørgensen M, Bæk R, Griss K, Han M, auf dem Brinke K, Timmesfeld N, Bertrams W, Greulich T, Koczulla AR, Hippenstiel S, Suttorp N, Schmeck B.

Surface proteome of plasma extracellular vesicles as biomarkers for pneumonia and acute exacerbation of COPD.

J Infect Dis. 2019 Oct 16. pii: jiz460

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Limburg H, Harbig A, Bestle D, Stein DA, Moulton HM, Jaeger J, Janga H, Hardes K, Koepke J, Schulte L, Koczulla AR, Schmeck B, Klenk HD, Böttcher-Friebertshäuser E.

TMPRSS2 is the major activating protease of influenza A virus in primary human airway cells and influenza B virus in human type II pneumocytes.

J Virol. 2019 Oct 15;93(21). pii: e00649-19

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Frantz R, Teubner L, Schultze T, La Pietra L, Müller C, Gwozdzinski K, Pillich H, Hain T, Weber-Gerlach M, Panagiotidis GD, Mostafa A, Weber F, Rohde M, Pleschka S, Chakraborty T, Abu Mraheil M.

The secRNome of Listeria monocytogenes Harbors Small Noncoding RNAs That Are Potent Inducers of Beta Interferon.

mBio. 2019. 10(5):e01223-19.

Schmoldt C, Vazquez-Armendariz AI, Shalashova I, Selvakumar B, Bremer CM, Peteranderl C, Witte B, Gattenloehner S, Fink L, Vadasz I, Morty RE, Pleschka S, Seeger W, Günther A, Herold S

IRE-1 signaling as putative therapeutic target in influenza virus-induced pneumonia.

Am J Respir Cell Mol Biol. 2019 Oct;61(4):537-540.

Dabrowski AN, Shrivastav A, Conrad C, Komma K, Weigel M, Dietert K, Gruber A, Bertrams W, Wilhelm J, Schmeck B, Reppe K, N'Guessan PD, Aly S, Suttorp N, Hain T, Zahlten J.

Peptidoglycan recognition protein 4 limits bacterial clearance and inflammation in lungs by control of the gut microbiota.

Front Immunol. 2019 Sep 20;10:2106

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Peteranderl C, Kuznetsova I, Schulze J, Hardt M, Lecuona E, Sznajder JI,  Vadász I, Morty RE, Pleschka S, Wolff T, Herold S

Influenza A virus infection induces apical redistribution of Na+, K+-ATPase in lung epithelial cells in vitro and in vivo.

Am J Respir Cell Mol Biol. 2019 Sep;61(3):395-398.

Loi VV, Huyen NTT, Busche T, Tung QN, Gruhlke MCH, Kalinowski J, Bernhardt J, Slusarenko AJ, Antelmann H.

Staphylococcus aureus responds to allicin by global S-thioallylation - Role of the Brx/BSH/YpdA pathway and the disulfide reductase MerA to overcome allicin stress

Free Radic Biol Med. 2019 Aug 1;139:55-69. doi: 10.1016/j.freeradbiomed.2019.05.018.

Lippitsch A, Baal N, Chukovetskyi Y, Cunningham S, Michel G, Dietert K, Gurtner C, Gruber AD, Bein G, Hackstein H

Plasmacytoid dendritic cell depletion modifies FoxP3+ T cell homeostasis and the clinical course of bacterial pneumonia in mice.

J Leukoc Biol. 2019 Jul 2

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Linzner N, Loi VV, Fritsch VN, Tung QN, Stenzel S, Wirtz M, Hell R, Hamilton C, Tedin K, Fulde M, Antelmann H.

Staphylococcus aureus Uses the Bacilliredoxin (BrxAB)/Bacillithiol Disulfide Reductase (YpdA) Redox Pathway to Defend Against Oxidative Stress Under Infections

Front Microbiol. 2019 Jun 18;10:1355. doi: 10.3389/fmicb.2019.01355.

Amarelle L, Katzen J, Shigemura M, Welch LC, Cajigas H, Peteranderl C, Celli D, Herold S, Lecuona E, Szanjder JI

Cardiac glycosides decrease influenza virus replication by inhibiting cell protein translational machinery.

Am J Physiol Lung Cell Mol Physiol. 2019 Jun 1;316(6):L1094-L1106.

Kaßmann M, Szijártó IA, García-Prieto CF, Fan G, Schleifenbaum J, Anistan YM, Tabeling C, Shi Y, le Noble F, Witzenrath M, Huang Y, Markó L, Nelson MT, Gollasch M.

Role of Ryanodine Type 2 Receptors in Elementary Ca2+ Signaling in Arteries and Vascular Adaptive Responses.

J Am Heart Assoc. 2019;8(9):e010090. https://pubmed.ncbi.nlm.nih.gov/31030596/

Brack MC, Lienau J, Kuebler WM, Witzenrath M.

Cardiovascular sequelae of pneumonia

Curr Opin Pulm Med. 2019 May;25(3):257-262. doi: 10.1097/MCP.0000000000000584.

Didiasova M, Zakrzewicz D, Schaefer L, Wygrecka M

When Place Matters: Shuttling of Enolase-1 Across Cellular Compartments.

Front Cell Dev Biol. 2019 Apr 26;7:61

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Nandakumar R, Tschismarov R, Meissner F, Prabakaran T, Krissanaprasit A, Farahani E, Zhang BC, Assil S, Martin A, Bertrams W, Holm CK, Ablasser A, Klause T, Thomsen MK, Schmeck B, Howard KA, Henry T, Gothelf KV, Decker T, Paludan SR

Intracellular bacteria engage a STING-TBK1-MVB12b pathway to enable paracrine cGAS-STING signalling.

Nat Microbiol. 2019 Apr;4(4):701-713, Epub 2019 Feb 25

https://www.ncbi.nlm.nih.gov/pubmed/30804548

Visekruna A, Hartmann S, Sillke YR, Glauben R, Fischer F, Raifer H, Mollenkopf H, Bertrams W, Schmeck B, Klein M, Pagenstecher A, Lohoff M, Jacob R, Pabst O, Bland PW, Luu M, Romero R, Siegmund B, Rajalingam K, Steinhoff U

Intestinal development and homeostasis require activation and apoptosis of diet-reactive T cells.

J Clin Invest. 2019 Apr 2;130. pii: 98929. eCollection 2019 Apr 2

https://www.ncbi.nlm.nih.gov/pubmed/30939122

Baal N, Cunningham S, Obermann HL, Thomas J, Lippitsch A, Dietert K, Gruber AD, Kaufmann A, Michel G, Nist A, Stiewe T, Rupp O, Goesmann A, Zukunft S, Fleming I, Bein G, Lohmeyer J, Bauer S, Hackstein H

ADAR1 Is Required for Dendritic Cell Subset Homeostasis and Alveolar Macrophage Function.

J Immunol. 2019 Feb 15;202(4):1099-1111

https://www.ncbi.nlm.nih.gov/pubmed/30651342

Scheller N, Herold S, Kellner R, Bertrams W, Jung AL, Janga H, Greulich T, Schulte LN, Vogelmeier CF, Lohmeyer J, Schmeck B

Proviral MicroRNAs Detected in Extracellular Vesicles From Bronchoalveolar Lavage Fluid of Patients With Influenza Virus-Induced Acute Respiratory Distress Syndrome.

J Infect Dis. 2019 Jan 29;219(4):540-543

https://www.ncbi.nlm.nih.gov/pubmed/30239899

Schulte LN, Bertrams W, Stielow C, Schmeck B

ncRNAs in Inflammatory and Infectious Diseases.

Methods Mol Biol. 2019;1912:3-32

https://www.ncbi.nlm.nih.gov/pubmed/30635888

Tung QN, Loi VV, Busche T, Nerlich A, Mieth M, Milse J, Kalinowski J, Hocke AC, Antelmann H.

Stable integration of the Mrx1-roGFP2 biosensor to monitor dynamic changes of the mycothiol redox potential in Corynebacterium glutamicum

Redox Biol. 2019 Jan;20:514-525

Kaplonek P, Khan N, Reppe K, Schumann B, Emmadi M, Lisboa MP, Xu FF, Calow ADJ, Parameswarappa SG, Witzenrath M, Pereira CL, Seeberger PH.

Improving vaccines against Streptococcus pneumoniae using synthetic glycans.

Proc Natl Acad Sci U S A 2018;115(52):13353-13358. https://pubmed.ncbi.nlm.nih.gov/30530654/

Fischer K, Doehn JM, Herr C, Lachner C, Heinrich A, Kershaw O, Voss M, Jacobson MH, Gruber AD, Clauss M, Witzenrath M, Bals R, Gutbier B, Slevogt H.

Acute Moraxella catarrhalis infection of chronically smoke-exposed mice increases mechanisms of emphysema development: a pilot study.

Eur J Microbiol Immunol (Bp.) 2018;8(4):128-134. https://pubmed.ncbi.nlm.nih.gov/30719329/

Oyama N, Winek K, Bäcker-Koduah P, Zhang T, Dames C, Werich M, Kershaw O, Meisel C, Meisel A, Dirnagl U.

Exploratory Investigation of Intestinal Function and Bacterial Translocation After Focal Cerebral Ischemia in the Mouse

Front Neurol. 2018 Nov 19;9:937. doi: 10.3389/fneur.2018.00937. eCollection 2018. https://pubmed.ncbi.nlm.nih.gov/30510535/

Berger S, Gökeri C, Gupta SK, Vera J, Dietert K, Behrendt U, Lienau J, Wienhold SM, Gruber AD, Suttorp N, Witzenrath M*, Nouailles G*.

Delay in antibiotic therapy results in fatal disease outcome in murine pneumococcal pneumonia.

Crit Care 2018;22(1):287. https://pubmed.ncbi.nlm.nih.gov/30382866/

Wienhold SM, Macrì M, Nouailles G, Dietert K, Gurtner C, Gruber AD, Heimesaat MM, Lienau J, Schumacher F, Kleuser B, Opitz B, Suttorp N, Witzenrath M*, Müller-Redetzky HC*.

Ventilator-induced lung injury is aggravated by antibiotic mediated microbiota depletion in mice.

Crit Care. 2018;22(1):282. https://pubmed.ncbi.nlm.nih.gov/30373626/

Didiasova M, Wujak L, Schaefer L, Wygrecka M.

Factor XII in coagulation, inflammation and beyond.

Cell Signal. 2018 Nov;51:257-265.

Grund C, Hoffmann D, Ulrich R, Naguib M, Schinköthe J, Hoffmann B, Harder T, Saenger S, Zscheppang K, Tönnies M, Hippenstiel S, Hocke A, Wolff T, Beer M.

A novel European H5N8 influenza A virus has increased virulence in ducks but low zoonotic potential

Emerg Microbes Infect. 2018 Jul 19;7(1):132.

Robak OH, Heimesaat MM, Kruglov AA, Prepens S, Ninnemann J, Gutbier B, Reppe K, Hochrein H, Suter M, Kirschning CJ, Marathe V, Buer J, Hornef MW, Schnare M, Schneider P, Witzenrath M, Bereswill S, Steinhoff U, Suttorp N, Sander LE, Chaput C, Opitz B

Antibiotic treatment-induced secondary IgA deficiency enhances susceptibility to Pseudomonas aeruginosa pneumonia.

J Clin Invest. 2018 Jul 16. pii: 97065

https://www.jci.org/articles/view/97065

Kalymbetova TV, Selvakumar B, Rodriguez-Castillo JA, Gunjak M, Malainou C, Heindl MR, Moiseenko A, Chao CM, Vadasz I, Mayer K, Lohmeyer J, Bellusci S, Bottcher-Friebertshauser E, Seeger W, Herold S, Morty RE

Resident alveolar macrophages are master regulators of arrested alveolarization in experimental bronchopulmonary dysplasia.

J Pathol. 2018 Jun;245(2):153-159

https://onlinelibrary.wiley.com/doi/epdf/10.1002/path.5076

Szijarto IA, Marko L, Filipovic MR, Miljkovic JL, Tabeling C, Tsvetkov D, Wang N, Rabelo LA, Witzenrath M, Diedrich A, Tank J, Akahoshi N, Kamata S, Ishii I, Gollasch M.

Cystathionine gamma-Lyase-Produced Hydrogen Sulfide Controls Endothelial NO Bioavailability and Blood Pressure.

Hypertension. 2018;71(6):1210-1217. https://pubmed.ncbi.nlm.nih.gov/29712741/

Keshavarz M, Skill M, Hollenhorst MI, Pfeil U, Walecki M, Kummer W, Krasteva-Christ G

Caveolin-3 differentially orchestrates cholinergic and serotonergic constriction of murine airways.

Sci Rep. 2018 May 14;8(1)

https://www.ncbi.nlm.nih.gov/pubmed/29760450

Zakrzewicz D, Didiasova M, Krüger M, Giaimo BD, Borggrefe T, Mieth M, Hocke AC, Zakrzewicz A, Schaefer L, Preissner KT, Wygrecka M

Protein arginine methyltransferase 5 mediates enolase-1 cell surface trafficking in human lung adenocarcinoma cells.

Biochim Biophys Acta. 2018 May;1864(5 Pt A):1816-1827

https://www.ncbi.nlm.nih.gov/pubmed/29501774

Herta T, Bhattacharyya A, Bollensdorf C, Kabus C, García P, Suttorp N, Hippenstiel S, Zahlten J

DNA-release by Streptococcus pneumoniae autolysin LytA induced Krueppel-like factor 4 expression in macrophages.

Sci Rep. 2018 Apr 10;8(1):5723

https://www.ncbi.nlm.nih.gov/pubmed/29636524

Perniss A, Schmidt N, Gurtner C, Dietert K, Schwengers O, Weigel M, Hempe J, Ewers C, Pfeil U, Gärtner U, Gruber AD, Hain T, Kummer W

Bordetella pseudohinzii targets cilia and impairs tracheal cilia-driven transport in naturally acquired infection in mice.

Sci Rep. 2018 Apr 9;8(1):5681

http://www.nature.com/articles/s41598-018-23830-4

Erickson NA, Dietert K, Enders J, Glauben R, Nouailles G, Gruber AD, Mundhenk L

Soluble mucus component CLCA1 modulates expression of leukotactic cytokines and BPIFA1 in murine alveolar macrophages but not in bone marrow-derived macrophages.

Histochem Cell Biol. 2018 Apr 2. doi: 10.1007/s00418-018-1664-y

https://www.ncbi.nlm.nih.gov/pubmed/29610986

Dittrich AS, Kühbandner I, Gehrig S, Rickert-Zacharias V, Twigg M, Wege S, Taggart CC, Herth F, Schultz C, Mall MA

Elastase activity on sputum neutrophils correlates with severity of lung disease in cystic fibrosis.

Eur Respir J. 2018 Mar 29;51(3). pii: 1701910

https://www.ncbi.nlm.nih.gov/pubmed/29545279

Schumann B, Reppe K, Kaplonek P, Wahlbrink A, Anish C, Witzenrath M, Pereira CL, Seeberger PH

Development of an Efficacious, Semisynthetic Glycoconjugate Vaccine Candidate against Streptococcus pneumoniae Serotype 1.

ACS Cent Sci. 2018 4,357-361.

https://www.ncbi.nlm.nih.gov/pubmed/29632881

Barbet G, Sander LE, Geswell M, Leonardi I, Cerutti A, Iliev I, Blander JM

Sensing Microbial Viability through Bacterial RNA Augments T Follicular Helper Cell and Antibody Responses.

Immunity 2018;48(3):584-598.e5

http://www.cell.com/immunity/pdfExtended/S1074-7613(18)30074-8

Ugolini M, Gerhard J, Burkert S, Jensen KJ, Georg P, Ebner F, Thada S, Dietert K, Helbig ET, Opitz B, Kurth F, Dittrich N, Sumanlatha G, Blander JM, Gruber AD, Hartmann S, Boekschoten MV, Suttorp N, Müller M, Jungersen G, Schumann RR, Sander LE

Recognition of microbial viability via TLR8 promotes T follicular helper cell differentiation and vaccine responses.

Nat Immunol  2018

https://www.nature.com/articles/s41590-018-0068-4

Dames C, Winek K, Beckers Y, Engel O, Meisel M, Meisel C

Immunomodulatory treatment with systemic GM-CSF augments pulmonary immune responses and improves neurological outcome after experimental stroke.

J Neuroimmunol. 2018 Mar 9. pii: S0165-5728(17)30548-9

http://www.jni-journal.com/article/S0165-5728(17)30548-9/fulltext

Schulte LN, Heinrich B, Janga H, Schmeck BT, Vázquez O

A Far-Red Fluorescent DNA Binder for Interaction Studies of Live Multidrug-Resistant Pathogens and Host.

Cells. Angew Chem Int Ed Engl. 2018 Sep 3;57(36):11564-11568

https://www.ncbi.nlm.nih.gov/pubmed/29972713

Janga H, Aznaourova M, Boldt F, Damm K, Grünweller A, Schulte LN

Cas9-mediated excision of proximal DNaseI/H3K4me3 signatures confers robust silencing of microRNA and long non-coding RNA genes.

PLoS One. 2018 Feb 16;13(2)

http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0193066

Tung QN, Linzner N, Loi VV, Antelmann H

Application of genetically encoded redox biosensors to measure dynamic changes in the glutathione, bacillithiol and mycothiol redox potentials in pathogenic bacteria.

Free Radic Biol Med. 2018 Feb 15. pii: S0891-5849(18)30073-X.

https://www.sciencedirect.com/science/article/pii/S089158491830073X?via%3Dihub

Gutbier B, Neuhauß AK, Reppe K, Ehrler C, Santel A, Kaufmann J, Scholz M, Weissmann N, Morawietz L, Mitchell TJ, Aliberti S, Hippenstiel S, Suttorp N, Witzenrath M; CAPNETZ and PROGRESS study groups

Prognostic and Pathogenic Role of Angiopoietin-1 and -2 in Pneumonia.

Am J Respir Crit Care Med. 2018 Feb 15

https://www.ncbi.nlm.nih.gov/pubmed/29447449

Yang G, Pillich H, White R, Czikora I, Pochic I, Yue Q, Hudel M, Gorshkov B, Verin A, Sridhar S, Isales CM, Eaton DC, Hamacher J, Chakraborty T, Lucas R

Listeriolysin O causes ENaC dysfunction in human airway epithelial cells.

Listeriolysin O causes ENaC dysfunction in human airway epithelial cells

https://www.ncbi.nlm.nih.gov/pubmed/29439494

Shrivastav A, Dabrowski AN, Conrad C, Baal N, Hackstein H, Plog S, Dietert K, Gruber AD, N'Guessan PD, Aly S, Suttorp N, Zahlten J

Peptidoglycan Recognition Protein 3 Does Not Alter the Outcome of Pneumococcal Pneumonia in Mice.

Front Microbiol. 2018 Feb 1;9:103

https://www.ncbi.nlm.nih.gov/pubmed/29449834

Becker SC, Szyska M, Mensen A, Hellwig K, Otto R, Olfe L, Volk HD, Dörner T, Dörken B, Scheibenbogen C, Schröder J, Hocke AC, Kang Na Il

A comparative analysis of human bone marrow-resident and peripheral memory B cells.

J Allergy Clin Immunol. 2018 Jan 31

https://www.ncbi.nlm.nih.gov/pubmed/29355676

Dietert K, Nouailles G, Gutbier B, Reppe K, Berger S, Jiang X, Schauer AE, Hocke AC, Herold S, Slevogt H, Witzenrath M, Suttorp N, Gruber AD

Digital Image Analyses on Whole Lung Slides in Mouse Models of Acute Pneumonia.

Am J Respir Cell Mol Biol. 2018 Jan 23.

https://www.atsjournals.org/doi/full/10.1165/rcmb.2017-0337MA

Mundhenk L, Erickson NA, Klymiuk N, and Gruber AD.

Interspecies Diversity of Chloride Channel Regulators, Calcium-Activated 3 Genes.

PLoS One. 2018 Jan 18;13(1):e0191512.

Nerlich A, Mieth M, Letsiou E, Fatykhova D, Zscheppang K, Matsushima AI, Meyer TF, Paasch L, Mitchell T, Tönnies M, Bauer TT, Schneider P, Neudecker J, Rückert J, Eggeling S, Schimek M, Witzenrath M, Suttorp N, Hippenstiel S, Hocke AC

Pneumolysin induced mitochondrial dysfunction leads to release of mitochondrial DNA.

Scientific Reports (2018) 8:182

https://www.nature.com/articles/s41598-017-18468-7

Ruiz-Moreno JS, Hamann L, Shah JA, Verbon A, Mockenhaupt FP, Puzianowska-Kuznicka M, Naujoks J, Sander LE, Witzenrath M, Cambier JC, Suttorp N, Schumann RR, Jin L, Hawn TR,  Opitz B,  CAPNETZ Study Group

The common HAQ STING variant impairs cGAS-dependent antibacterial responses and is associated with susceptibility to Legionnaires' disease in humans.

PLoS Pathog. 2018 Jan 3;14(1)

http://journals.plos.org/plospathogens/article?id=10.1371/journal.ppat.1006829

Gutbier B, Schönrock SM, Ehrler C, Haberberger R, Dietert K, Gruber AD, Kummer W, Michalik L, Kübler WM, Hocke AC, Szymanski K, Letsiou E, Lüth A, Schumacher F, Kleuser B, Mitchell TJ, Bertrams W, Schmeck B, Treue D, Klauschen F, Bauer TT, Tönnies M,

Sphingosine kinase 1 regulates inflammation and contributes to acute lung injury in pneumococcal pneumonia via the S1P receptor 2.

Crit Care Med. 2018 Jan 2.

https://www.ncbi.nlm.nih.gov/pubmed/29298188

Frevert CW, Felgenhauer J, Wygrecka M, Nastase MV, Schaefer L.

Danger-Associated Molecular Patterns Derived From the Extracellular Matrix Provide Temporal Control of Innate Immunity.

Danger-Associated Molecular Patterns Derived From the Extracellular Matrix Provide Temporal Control of Innate Immunity

https://www.ncbi.nlm.nih.gov/pubmed/29290139

Boutin S, Depner M, Stahl M, Graeber SY, Dittrich SA, Legatzki A, von Mutius E, Mall M, Dalpke AH

Comparison of Oropharyngeal Microbiota from Children with Asthma and Cystic Fibrosis.

Mediators Inflamm. 2017;2017:5047403

https://www.ncbi.nlm.nih.gov/pubmed/29445257

Ruiz-Moreno JS, Hamann L, Jin L, Sander LE, Puzianowska-Kuznickad M, Cambier JC, Witzenrath M, Schumann RR, Suttorp N, Opitz B, CAPNETZ Study Group

The cGAS/STING pathway detects Streptococcus pneumoniae but is dispensable for anti-pneumococcal defense in mice and humans.

Infect Immun. 2017 Dec 20. pii: IAI.00849-17

http://iai.asm.org/content/early/2017/12/13/IAI.00849-17.abstract

Fischer S, Noll, F, Behnke J, Leitling S, Troidl K, Teixeira Alves G, Preissner, KT

Self-extracellular RNA acts in synergy with exogenous danger signals to promote inflammation.

PLoS One. 2017 Dec 20;12(12):e0190002

https://doi.org/10.1371/journal.pone.0190002

Heß N, Waldow F, Kohler TP, Rohde M, Kreikemeyer B, Gómez-Mejia A, Hain T, Schwudke D, Vollmer W, Hammerschmidt S, Gisch N

LTA deficiency permits normal growth but impairs virulence of Streptococcus pneumoniae.

Nat Commun. 2017 Dec 12;8(1):2093

https://www.ncbi.nlm.nih.gov/pubmed/29233962

Horn V, Triantafyllopoulou A

DNA damage signaling and polyploid macrophages in chronic inflammation.

Curr Opin Immunol. 2017 Dec 1;50:55-63

https://www.ncbi.nlm.nih.gov/pubmed/29202328

Jensen AV, Faurholt-Jepsen D, Egelund GB, Andersen SB, Petersen PT, Benfield T, Witzenrath M, Rohde G, Ravn P; German Community-Acquired Pneumonia Competence Network (CAPNETZ)

Undiagnosed Diabetes Mellitus in Community-Acquired Pneumonia: A Prospective Cohort Study.

Clin Infect Dis. 2017 Nov 29;65(12):2091-2098

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Proc Natl Acad Sci U S A 114: E3385-E3389, 2017

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The Randomized Controlled STRAWINSKI Trial: Procalcitonin-Guided Antibiotic Therapy after Stroke

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Fgf10 deficiency is causative for lethality in a mouse model of bronchopulmonary dysplasia.

J Pathol. 2017 Jan;241(1):91-103

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J Immunol December 7, 2016, 1601585

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J Allergy Clin Immunol. 2016 Jul;138(1):47-56

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Stroke. 2016 May;47(5):1354-63

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J Cereb Blood Flow Metab. 2016 Jan 1:271678X16671964

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Respir Res. 2015 Oct 6;16:123

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Zahlten J, Herta T, Kabus C, Steinfeldt M, Kershaw O, García P, Hocke AC, Gruber AD, Hübner RH, Steinicke R, Doehn JM, Suttorp N, Hippenstiel S

Role of Pneumococcal Autolysin for KLF4 Expression and Chemokine Secretion in Lung Epithelium.

Am J Respir Cell Mol Biol. 2015 Oct;53(4):544-54

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Eur Respir Rev. 2015 Sep;24(137):516-24

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Fisetin protects against Listeria monocytogenes infection by reducing the listeriolysin O production.

J Infect Dis. 2015; pii:jiv437.

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Prevention of stroke-associated pneumonia: where next?

Lancet. 2015 Sep 3. pii: S0140-6736(15)00127-0

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Fatykhova D, Rabes A, Machnik C, Guruprasad K, Pache F, Berg J, Toennies M, Bauer TT, Schneider P, Schimek M, Eggeling S, Mitchell TJ, Mitchell AM, Hilker R, Hain T, Suttorp N, Hippenstiel S, Hocke AC, Opitz B

Serotype 1 and 8 Pneumococci Evade Sensing by Inflammasomes in Human Lung Tissue.

PLoS One. 2015 Aug 28;10(8):e0137108

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Gutbier B, Fischer K, Doehn JM, von Lachner C, Herr C, Klaile E, Frischmann U, Singer BB, Riesbeck K, Zimmermann W, Suttorp N, Bachmann S, Bals R, Witzenrath M, Slevogt H

Moraxella catarrhalis induces an immune response in the murine lung that is independent of human CEACAM5 expression and long-term smoke exposure.

Am J Physiol Lung Cell Mol Physiol. 2015 Aug 1;309(3):L250-61

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Recum-Knepper J, Sadewasser A, Weinheimer VK, Wolff T

Fluorescence-Activated Cell Sorting-Based Analysis Reveals an Asymmetric Induction of Interferon-Stimulated Genes in Response to Seasonal Influenza A Virus.

J Virol. 2015 Jul 15;89(14):6982-93

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Soultanova A, Voigt A, Chubanov V, Gudermann T, Meyerhof W, Boehm U, Kummer W

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Int Immunopharmacol. 2015 Nov;29(1):143-7

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Smith CJ, Kishore AK, Vail A, Chamorro A, Garau J, Hopkins SJ, Di Napoli M, Kalra L, Langhorne P, Montaner J, Roffe C, Rudd AG, Tyrrell PJ, van de Beek D, Woodhead M, Meisel A.

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Stroke. 2015 Jun 25. pii: STROKEAHA.115.009617.

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Influenza virus-induced caspase-dependent enlargement of nuclear pores promotes nuclear export of viral ribonucleoprotein complexes.

J Virol. 2015 Jun 1;89(11):6009-21

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Jung S, von Thulen T, Laukemper V, Pigisch S, Hangel D, Wagner H, Kaufmann A, Bauer S

A single naturally occurring 2'-O-methylation converts a TLR7- and TLR8-activating RNA into a TLR8-specific ligand.

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Hecker M, Linder T, Ott J, Walmrath HD, Lohmeyer J, Vadász I, Marsh LM, Herold S, Reichert M, Buchbinder A, Morty RE, Bausch B, Fischer T, Schulz R, Grimminger F, Witzenrath M, Barnes M, Seeger W, Mayer K

Immunomodulation by lipid emulsions in pulmonary inflammation: a randomized controlled trial.

Crit Care. 2015 May 12;19:226

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Müller-Redetzky HC, Wienhold SM, Berg J, Hocke AC, Hippenstiel S, Hellwig K, Gutbier B, Opitz B, Neudecker J, Rückert J, Gruber AC, Kershaw O, Mayer K,  Suttorp N, Witzenrath M

Moxifloxacin is not anti-inflammatory in experimental pneumococcal pneumonia.

J Antimicrob Chemother. 2015 Mar;70(3):830-40

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Kishore AK, Vail A, Chamorro A, Garau J, Hopkins SJ, Di Napoli M, Kalra L, Langhorne P, Montaner J, Roffe C, Rudd AG, Tyrrell PJ, van de Beek D, Woodhead M, Meisel A, Smith CJ

How is pneumonia diagnosed in clinical stroke research? A systematic review and meta-analysis.

Stroke. 2015 May;46(5):1202-9.

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Lancet. 2015 Apr 18;385(9977):1486-7

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Tabeling C, Yu H, Wang L, Ranke H, Goldenberg NM, Zabini D, Noe E, Krauszman A, Gutbier B, Yin J, Schaefer M, Arenz C, Hocke AC, Suttorp N, Proia RL, Witzenrath M, Kuebler WM

CFTR and sphingolipids mediate hypoxic pulmonary vasoconstriction.

Proc Natl Acad Sci U S A. 2015 Mar 31;112(13):E1614-23

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Didiasova M, Zakrzewicz D, Magdolen V, Nagaraj C, Bálint Z, Rohde M, Preissner KT, Wygrecka M

STIM1/ORAI1-mediated Ca2+ Influx Regulates Enolase-1 Exteriorization.

J Biol Chem. 2015 May 8;290(19):11983-99

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Wujak L, Didiasova M, Zakrzewicz D, Frey H, Schaefer L, Wygrecka M

Heparan sulfate proteoglycans mediate factor XIIa binding to the cell surface.

J Biol Chem. 2015 Mar 13;290(11):7027-39

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Zahlten J, Herta T, Kabus C, Steinfeldt M, Kershaw O, García P, Hocke AC, Gruber AD, Hübner RH, Steinicke R, Doehn JM, Suttorp N, Hippenstiel S

Pneumococci LytA-dependent KLF4 Expression Terminates IL-8 Secretion in Lung Epithelium.

Am J Respir Cell Mol Biol. 2015 Mar 10

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Dietert K, Mundhenk L, Erickson NA, Reppe K, Hocke AC, Kummer W, Witzenrath M, Gruber AD

Murine CLCA5 is uniquely expressed in distinct niches of airway epithelial cells.

Histochem Cell Biol. 2015 Mar;143(3):277-87. doi: 10.1007/s00418-014-1279-x.

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Cabrera-Fuentes HA, Lopez ML, McCurdy S, Fischer S, Meiler S, Baumer Y, Galuska SP, Preissner KT, Boisvert WA

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Thromb Haemost. 2015 Mar;113(3):473-81

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Rabes A, Zimmermann S, Reppe K, Lang R, Seeberger PH, Suttorp N, Witzenrath M, Lepenies B, Opitz B

The C-type lectin receptor Mincle binds to Streptococcus pneumoniae but plays a limited role in the anti-pneumococcal innate immune response.

PLoS One. 2015 Feb 6;10(2):e0117022

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Müller-Redetzky HC, Felten M, Hellwig K, Wienhold SM, Naujoks J, Opitz B, Kershaw O, Gruber AD, Suttorp N, Witzenrath M

Increasing the inspiratory time and I:E ratio during mechanical ventilation aggravates ventilator-induced lung injury in mice.

Critical Care 2015, 19:23

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Loose M, Hudel M, Zimmer KP, Garcia E, Hammerschmidt S, Lucas R, Chakraborty T, Pillich H

Pneumococcal hydrogen peroxide-induced stress signaling regulates inflammatory genes.

J Infect Dis. 2015 Jan 15;211(2):306-16

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Zahlten J, Kim YJ, Doehn JM, Pribyl T, Hocke AC, García P, Hammerschmidt S, Suttorp N, Hippenstiel S, Hübner RH

Streptococcus pneumoniae-Induced Oxidative Stress in Lung Epithelial Cells Depends on Pneumococcal Autolysis and Is Reversible by Resveratrol.

J Infect Dis. 2015 Jun 1;211(11):1822-1830

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Moonlighting proteins dictate the crosstalk between thrombosis and innate immunity.

J Thromb Haemost. 2014 Dec;12(12):2070-3

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Dames C, Akyüz L, Reppe K, Tabeling C, Dietert K, Kershaw O, Gruber AD, Meisel C, Meisel A, Witzenrath M, Engel O

Miniaturized bronchoscopy enables unilateral investigation, application, and sampling in mice.

Am J Respir Cell Mol Biol. 2014 Dec;51(6):730-7

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Savai R, Al-Tamari HM, Sedding D, Kojonazarov B, Muecke C, Teske R, Capecchi MR, Weissmann N, Grimminger F, Seeger W, Schermuly RT, Pullamsetti SS

Pro-proliferative and inflammatory signaling converge on FoxO1 transcription factor in pulmonary hypertension.

Nat Med. 2014 Nov;20(11):1289-300

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Cavallari M, Stallforth P, Kalinichenko A, Rathwell DC, Gronewold TM, Adibekian A, Mori L, Landmann R, Seeberger PH

A semisynthetic carbohydrate-lipid vaccine that protects against S. pneumoniae in mice.

Nat Chem Biol. 2014 Nov;10(11):950-6

Conrad T, Marsico A, Gehre M, Orom UA

Microprocessor activity controls differential miRNA biogenesis In Vivo.

Cell Rep. 2014 Oct 23;9(2):542-54

 

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Becker MO, Kill A, Kutsche M, Guenther J, Rose A, Tabeling C, Witzenrath M, Kühl AA, Heidecke H, Ghofrani HA, Tiede H, Nickel N, Hoeper MM, Lukitsch I, Gollasch M, Kuebler WM, Bock S, Burmester GR, Dragun D, Riemekasten G

Vascular receptor autoantibodies in pulmonary arterial hypertension associated with systemic sclerosis.

Am J Respir Crit Care Med. 2014 Oct 1;190(7):808-17

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Czikora I, Alli A, Bao HF, Kaftan D, Sridhar S, Apell HJ, Gorshkov B, White R, Zimmermann A, Wendel A, Pauly-Evers M, Hamacher J, Garcia-Gabay I, Fischer B, Verin A, Bagi Z, Pittet JF, Shabbir W, Lemmens-Gruber R, Chakraborty T, Lazrak A, Matthay MA, Eato

A novel tumor necrosis factor-mediated mechanism of direct epithelial sodium channel activation.

Am J Respir Crit Care Med. 2014 Sep 1;190(5):522-32

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Noe E, Tabeling C, Doehn JM, Naujoks J, Opitz B, Hippenstiel S, Witzenrath M, Klopfleisch R

Juvenile megaesophagus in PKCα-deficient mice is associated with an increase in the segment of the distal esophagus lined by smooth muscle cells.

Ann Anat. 2014 Sep;196(5):365-71

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Veith NT, Tschernig T, Gutbier B, Witzenrath M, Meier C, Menger M, Bischoff M

Surfactant protein A mediates pulmonary clearance of Staphylococcus aureus.

Respir Res. 2014 Aug 5;15:85

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Heine G, Tabeling C, Hartmann B, González Calera CR, Kühl AA, Lindner J, Radbruch A, Witzenrath M, Worm M

25-hydroxvitamin D3 promotes the long-term effect of specific immunotherapy in a murine allergy model.

J Immunol. 2014 Aug 1;193(3)

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Dietert K, Reppe K, Mundhenk L, Witzenrath M, Gruber A

mCLCA3 Modulates IL-17 and CXCL-1 Induction and Leukocyte Recruitment in Murine Staphylococcus aureus Pneumonia

PLoS One. 2014 Jul 17;9(7)

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Czikora I, Sridhar S, Gorshkov B, Alieva IB, Kasa A, Gonzales J, Potapenko O, Umapathy NS, Pillich H, Rick FG, Block NL, Verin AD, Chakraborty T, Mattay MA, Schally AV, Lucas R.

Protective effect of growth hormone-releasing hormone agonist in bacterial toxin-induced pulmonary barrier dysfunction.

Front Physiol. 2014; 5:259.

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Endothelial progenitor cells for acute respiratory distress syndrome treatment: support your local sheriff!

Am J Respir Crit Care Med. 2014 Jun 15;189(12):1452-5

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Weissmann N, Peters DM, Klöpping C, Krüger K, Pilat C, Katta S, Seimetz M, Ghofrani HA, Schermuly RT, Witzenrath M, Seeger W, Grimminger F, Mooren FC

Structural and functional prevention of hypoxia-induced pulmonary hypertension by individualized exercise training in mice.

Am J Physiol Lung Cell Mol Physiol. 2014 Jun 1;306(11):L986-95

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Zakrzewicz D, Didiasova M, Zakrzewicz A, Hocke AC, Uhle F, Markart P, Preissner KT, Wygrecka M

The interaction of enolase-1 with caveolae-associated proteins regulates its subcellular localization.

Biochem J. 2014 Jun 1;460(2):295-307

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Tabeling C, Scheer H, Schönrock SM, Runge F, Gutbier B, Lienau J, Hamelmann E, Opitz B, Suttorp N, Mayer K, Behrens GM, Tschernig T, Witzenrath M

Nucleotide oligomerization domain 1 ligation suppressed murine allergen-specific T-cell proliferation and airway hyperresponsiveness.

Am J Respir Cell Mol Biol. 2014 May;50(5):903-11

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Hecker M, Ott J, Sondermann C, Schaefer M, Obert M, Hecker A, Morty RE, Vadasz I, Herold S, Rosengarten B, Witzenrath M, Seeger W, Mayer K

Immunomodulation by fish-oil containing lipid emulsions in murine acute respiratory distress syndrome.

Crit Care. 2014 Apr 29;18(2):R85

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Müller-Redetzky HC, Will D, Hellwig K, Kummer W, Tschernig T, Pfeil U, Paddenberg R, Menger MD, Kershaw O, Gruber AD, Weissmann N, Hippenstiel S, Suttorp N, Witzenrath M

Mechanical ventilation drives pneumococcal pneumonia into lung injury and sepsis in mice: protection by adrenomedullin.

Crit Care. 2014 Apr 14;18(2):R73.

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Krljanac B, Weih D, Jacobsen ID, Hu D, Koliesnik I, Reppe K, Witzenrath M, Weih F.

NF-κB2/p100 deficiency impairs immune responses to T-cell-independent type 2 antigens.

Eur J Immunol. 2014 Mar;44(3):662-72

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Müller-Redetzky HC, Suttorp N, Witzenrath M

Dynamics of pulmonary endothelial barrier function in acute inflammation: mechanisms and therapeutic perspectives.

Cell Tissue Res. 2014 Mar;355(3):657-73

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Kill A, Tabeling C, Undeutsch R, Kühl AA, Günther J, Radic M, Becker MO, Heidecke H, Worm M, Witzenrath M, Burmester GR, Dragun D, Riemekasten G

Autoantibodies to angiotensin and endothelin receptors in systemic sclerosis induce cellular and systemic events associated with disease pathogenesis.

Arthritis Res Ther. 2014 Jan 28;16(1):R29

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Peters DM, Vadász I, Wujak L, Wygrecka M, Olschewski A, Becker C, Herold S, Papp

TGF-ß directs trafficking of the epithelial sodium channel ENaC which has implications for ion and fluid transport in acute lung injury.

Proc Natl Acad Sci U S A. 2014 Jan 21;111(3):E374-83

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Herold S, Hoegner K, Vadász I, Gessler T, Wilhelm J, Mayer K, Morty RE, Walmrath

Inhaled GM-CSF as treatment of pneumonia-associated ARDS

Am J Respir Crit Care Med. 2014 Mar 1;189(5):609-11

Malczyk M, Veith C, Fuchs B, Hofmann K, Storch U, Schermuly RT, Witzenrath M, Ah

Classical Transient Receptor Potential Channel 1 in Hypoxia-induced Pulmonary Hypertension.

Am J Respir Crit Care Med. 2013 Dec 15;188(12):1451-9.

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Schütz F, Hackstein H

Identification of novel dendritic cell subset markers in human blood.

Biochem Biophys Res Commun. 2013 Dec 7. pii: S0006-291X(13)02024-X. doi: 10.1016/j.bbrc.2013.11.112.

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Witsch TJ, Turowski P, Sakkas E, Niess G, Becker S, Herold S, Mayer K, Vadász I, Roberts JD Jr, Seeger W, Morty RE.

Deregulation of the lysyl hydroxylase matrix cross-linking system in experimental and clinical bronchopulmonary dysplasia.

Am J Physiol Lung Cell Mol Physiol. 2013 Nov 27.

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Tabeling C, Scheer H, Schönrock SM, Runge F, Gutbier B, Lienau J, Hamelmann E, Opitz B, Suttorp N, Mayer K, Behrens GM, Tschernig T, Witzenrath M.

NOD1 Ligation Suppressed Murine Allergen-Specific T Cell Proliferation and Airway Hyperresponsiveness.

Am J Respir Cell Mol Biol. 2013 Nov 26.

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Schulz R, Murzabekova G, Egemnazarov B, Kraut S, Eisele HJ, Dumitrascu R, Heitmann J, Seimetz M, Witzenrath M, Ghofrani HA, Schermuly RT, Grimminger F, Seeger W, Weissmann N.

Arterial hypertension in a murine model of sleep apnea: role of NADPH oxidase 2.

J Hypertens. 2013 Nov 21.

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Naujoks J, Opitz B

Bacterial infections and the DNA sensing pathway

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Chaput C, Sander LE, Suttorp N, Opitz B

NOD-Like Receptors in Lung Diseases.

Front Immunol. 2013, 4, 393.

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Mukhametshina RT, Ruhs A, Singh I, Hasan D, Contreras A, Mehta A, Nikam VS, Ahlbrecht K, Carraro G, Cabrera-Fuentes HA, Jiang D, Voswinckel R, Seeger W, Bellusci S, Scharffetter-Kochanek K, Bagaeva TV, Preissner KT, Boettger T, Braun T, Krüger M, Barreto

Quantitative Proteome Analysis of Alveolar Type-II Cells Reveals a Connection of Integrin Receptor Subunits Beta 2/6 and WNT Signaling.

J Proteome Res. 2013 Dec 6;12(12):5598-608. doi: 10.1021/pr400573k. Epub 2013 Nov 18.

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Schwartze JT, Becker S, Sakkas E, Wujak LA, Niess G, Usemann J, Reichenberger F, Herold S, Vadasz I, Mayer K, Seeger W, Morty RE.

Glucocorticoids recruit Tgfbr3 and Smad1 to shift transforming growth factor-ß signaling from the Tgfbr1/Smad2/3 axis to the Acvrl1/Smad1 axis in lung fibroblasts.

J Biol Chem. 2013 Dec 17

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Knepper J, Schierhorn KL, Becher A, Budt M, Tönnies M, Bauer TT, Schneider P, Neudecker J, Rückert JC, Gruber AD, Suttorp N, Schweiger B, Hippenstiel S, Hocke AC, Wolff T

The novel human influenza A(H7N9) virus is naturally adapted to efficient growth in human lung tissue

MBio. 2013 Oct 8;4(5). pii: e00601-13. doi: 10.1128/mBio.00601-13.

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Hocke AC, Becher A, Knepper J, Peter A, Holland G, Tönnies M, Bauer TT, Schneider P, Neudecker J, Muth D, Wendtner CM, Rückert JC, Drosten C, Gruber AD, Laue M, Suttorp N, Hippenstiel S, Wolff T.

Emerging Human Middle East Respiratory Syndrome Coronavirus Causes Widespread Infection and Alveolar Damage in Human Lungs.

Am J Respir Crit Care Med. 2013 Oct 1;188(7):882-886.

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Grzesik BA, Vohwinkel C, Morty RE, Mayer K, Herold S, Seeger W, Vadász I

Efficient gene delivery to primary alveolar epithelial cells by nucleofection.

Am J Physiol Lung Cell Mol Physiol 2013, 305: 786-94

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Hackstein H, Kranz S, Lippitsch A, Wachtendorf A, Kershaw O, Gruber AD, Michel G, Lohmeyer J, Bein G, Baal N, Herold S.

Modulation of respiratory dendritic cells during Klebsiella pneumonia infection.

Resp Res 2013 Sept 17;14(1):91 [Epub ahead of print].

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Herold S, Gabrielli NM, Vadasz I.

Novel concepts of acute lung injury and alveolo-capillary barrier dysfunction.

Am J Physiol Lung Cell Mol Physiol. 13 Sept 2013, DOI: 10.1152/ajplung.00232.2013

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Bayat B, Tjahjono Y, Sydykov A, Werth S, Hippenstiel S, Weissmann N, Sachs UJ, Santoso S.

Anti-Human Neutrophil Antigen-3a Induced Transfusion-Related Acute Lung Injury in Mice by Direct Disturbance of Lung Endothelial Cells.

Arterioscler Thromb Vasc Biol. 2013 Sep 12. [Epub ahead of print]

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Effects of dimethylarginine dimethylaminohydrolase-1 overexpression on the response of the pulmonary vasculature to hypoxia

Am J Respir Cell Mol Biol. 2013 Sep;49(3):491-500

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Marsico A, Huska MR, Lasserre J, Hu H, Vucicevic D, Musahl A, Orom UA, Vingron M.

PROmiRNA: a new miRNA promoter recognition method uncovers the complex regulation of intronic miRNAs.

Genome Biol. 2013 Aug 16;14(8)

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Lucas R, Czikora I, Sridhar S, Zemskov EA, Oseghale A, Circo S, Cederbaum SD, Chakraborty T, Fulton DJ, Caldwell RW, Romero MJ.

Arginase 1: an unexpected mediator of pulmonary capillary barrier dysfunction in models of acute lung injury.

Front Immunol. 2013, 4:228

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von Deetzen MC, Schmeck B, Gruber AD, Klopfleisch R.

Molecular quantification of canine specific microRNA species.

Res Vet Sci. 2013 Oct;95(2):562-8. Epub 2013 Jul 22.

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Lucas R, Czikora I, Sridhar S, Zemskov E, Gorshkov B, Siddaramappa U, Oseghale A, Lawson J, Verin A, Rick FG, Block NL, Pillich H, Romero M, Leustik M, Schally AV, Chakraborty T.

Mini-review: Novel therapeutic strategies to blunt actions of pneumolysin in the lungs.

Toxins (Basel). 2013, 5:1244-1260.

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Fulde M, Bernardo-García N, Rohde M, Nachtigall N, Frank R, Preissner KT, Klett J, Morreale A, Chhatwal GS, Hermoso JA, Bergmann S.

Pneumococcal phosphoglycerate kinase interacts with plasminogen and its tissue activator.

Thromb Haemost. 2013 Nov 7;111(3). [Epub ahead of print]

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Sittka A, Schmeck B.

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Adv Exp Med Biol. 2013;774:121-34. doi: 10.1007/978-94-007-5590-1_7. Review.

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