Transregio SFB-TR 84 “Innate Immunity of the Lung: Mechanisms of Pathogen Attack and Host Defence in Pneumonia“

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Publications

Robak OH, Heimesaat MM, Kruglov AA, Prepens S, Ninnemann J, Gutbier B, Reppe K, Hochrein H, Suter M, Kirschning CJ, Marathe V, Buer J, Hornef MW, Schnare M, Schneider P, Witzenrath M, Bereswill S, Steinhoff U, Suttorp N, Sander LE, Chaput C, Opitz B

Antibiotic treatment-induced secondary IgA deficiency enhances susceptibility to Pseudomonas aeruginosa pneumonia.

J Clin Invest. 2018 Jul 16. pii: 97065

www.jci.org/articles/view/97065

Schumann B, Reppe K, Kaplonek P, Wahlbrink A, Anish C, Witzenrath M, Pereira CL, Seeberger PH

Development of an Efficacious, Semisynthetic Glycoconjugate Vaccine Candidate against Streptococcus pneumoniae Serotype 1.

ACS Cent Sci. 2018 4,357-361.

www.ncbi.nlm.nih.gov/pubmed/29632881

Barbet G, Sander LE, Geswell M, Leonardi I, Cerutti A, Iliev I, Blander JM

Sensing Microbial Viability through Bacterial RNA Augments T Follicular Helper Cell and Antibody Responses.

Immunity 2018;48(3):584-598.e5

www.cell.com/immunity/pdfExtended/S1074-7613(18)30074-8

Ugolini M, Gerhard J, Burkert S, Jensen KJ, Georg P, Ebner F, Thada S, Dietert K, Helbig ET, Opitz B, Kurth F, Dittrich N, Sumanlatha G, Blander JM, Gruber AD, Hartmann S, Boekschoten MV, Suttorp N, Müller M, Jungersen G, Schumann RR, Sander LE

Recognition of microbial viability via TLR8 promotes T follicular helper cell differentiation and vaccine responses.

Nat Immunol  2018

www.nature.com/articles/s41590-018-0068-4

Ruiz-Moreno JS, Hamann L, Jin L, Sander LE, Puzianowska-Kuznickad M, Cambier JC, Witzenrath M, Schumann RR, Suttorp N, Opitz B, CAPNETZ Study Group

The cGAS/STING pathway detects Streptococcus pneumoniae but is dispensable for anti-pneumococcal defense in mice and humans.

Infect Immun. 2017 Dec 20. pii: IAI.00849-17

iai.asm.org/content/early/2017/12/13/IAI.00849-17.abstract

Dietert K, Gutbier B, Wienhold SM, Reppe K, Jiang X, Yao L, Chaput C, Naujoks J, Brack M, Kupke A, Peteranderl C, Becker S, von Lachner C, Baal N, Slevogt H, Hocke AC, Witzenrath M, Opitz B, Herold S, Hackstein H, Sander LE, Suttorp N, Gruber AD

Spectrum of pathogen- and model-specific histopathologies in mouse models of acute pneumonia.

PLoS One. 2017 Nov 20;12(11):e0188251

www.ncbi.nlm.nih.gov/pubmed/29155867

Emmadi M, Khan N, Lykke L, Reppe K, Parameswarappa S, Lisboa MP, Wienhold SM, Witzenrath M, Pereira CL, Seeberger PH

A Streptococcus pneumoniae type 2 oligosaccharide glycoconjugate elicits opsonic antibodies and is protective in an animal model of invasive pneumococcal disease.

J Am Chem Soc 2017 Oct 4 [Epub ahead of print]

www.ncbi.nlm.nih.gov/pubmed/28945368

Lisboa MP, Khan N, Martin C, Xu FF, Reppe K, Geissner A, Govindan S, Witzenrath M, Pereira CL, Seeberger PH

Semisynthetic glycoconjugate vaccine candidate against Streptococcus pneumoniae serotype 5.

Proc Natl Acad Sci USA 2017 Oct 2 [Epub ahead of print]

www.ncbi.nlm.nih.gov/pubmed/28973947

Seeberger PH, Pereira CL, Khan N, Xiao G, Diago-Navarro E, Reppe K, Opitz B, Fries BC, Witzenrath M

A semi-synthetic glycoconjugate vaccine candidate for carbapenem-resistant Klebsiella pneumoniae.

Angew Chem Int Ed Engl. 2017 Aug 16

www.pubmed.de/gateway/nlm-pubmed/28815890

Hahm HS, Schlegel MK, Hurevich M, Eller S, Schuhmacher F, Hofmann J, Pagel K, and Seeberger PH

Automated glycan assembly using the Glyconeer 2.1 synthesizer.

Proc Natl Acad Sci U S A 114: E3385-E3389, 2017

www.ncbi.nlm.nih.gov/pubmed/28396442

Schumann B, Hahm HS, Parameswarappa SG, Reppe K, Wahlbrink A, Govindan S, Kaplonek P, Pirofski LA, Witzenrath M, Anish C, Pereira CL, Seeberger PH

A semisynthetic Streptococcus pneumoniae serotype 8 glycoconjugate vaccine.

Sci Transl Med. 2017 Mar 8;9(380)

www.ncbi.nlm.nih.gov/pubmed/28275152

Druzd D, Matveeva O, Ince L, Harrison U, He W, Schmal C, Herzel H, Tsang AH, Kawakami N, Leliavski A, Uhl O, Yao L, Sander LE, Chen CS, Kraus K, de Juan A, Hergenhan SM, Ehlers M, Koletzko B, Haas R, Solbach W, Oster H, Scheiermann C

Lymphocyte Circadian Clocks Control Lymph Node Trafficking and Adaptive Immune Responses.

Immunity. 2017 Jan 17;46(1):120-132

www.sciencedirect.com/science/article/pii/S1074761316305179

Parameswarappa SG, Reppe K, Geissner A, Ménová P, Govindan S, Calow AD, Wahlbrink A, Weishaupt MW, Monnanda BP, Bell RL, Pirofski LA, Suttorp N, Sander LE, Witzenrath M, Pereira CL, Anish C, Seeberger PH

A Semi-synthetic Oligosaccharide Conjugate Vaccine Candidate Confers Protection against Streptococcus pneumoniae Serotype 3 Infection.

Cell Chem Biol. 2016 Nov 2. pii: S2451-9456(16)30356-7

www.ncbi.nlm.nih.gov/pubmed/27818299

Garaude J, Acín-Pérez R, Martínez-Cano S, Enamorado M, Ugolini M, Nistal-Villán E, Hervás-Stubbs S, Pelegrín P, Sander LE, Enríquez JA, Sancho D

Mitochondrial respiratory-chain adaptations in macrophages contribute to antibacterial host defense.

Nat Immunol. 2016 Sep;17(9):1037-45

www.ncbi.nlm.nih.gov/pubmed/27348412

Kostadinova E, Chaput C, Gutbier B, Lippmann J, Sander LE, Mitchell TJ, Suttorp N, Witzenrath M, Opitz B

NLRP3 protects alveolar barrier integrity by an inflammasome-independent increase of epithelial cell adherence

Sci Rep. 2016 Aug 1;6:30943

www.ncbi.nlm.nih.gov/pubmed/27476670