Transregio SFB-TR 84 “Innate Immunity of the Lung: Mechanisms of Pathogen Attack and Host Defence in Pneumonia“

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Publications

Hillus D, Schwarz T, Tober-Lau P, Vanshylla K, Hastor H, Thibeault C, Jentzsch S, Helbig ET, Lippert LJ, Tscheak P, Schmidt ML, Riege J, Solarek A, von Kalle C, Dang-Heine C, Gruell H, Kopankiewicz P, Suttorp N, Drosten C, Bias H, Seybold J; EICOV/COVIM Study Group, Klein F, Kurth F, Corman VM, Sander LE.

Safety, reactogenicity, and immunogenicity of homologous and heterologous prime-boost immunisation with ChAdOx1 nCoV-19 and BNT162b2: a prospective cohort study.

Lancet Respir Med. 2021 Aug 12:S2213-2600(21)00357-X. doi: 10.1016/S2213-2600(21)00357-X. Epub ahead of print. PMID: 34391547; PMCID: PMC8360702. pubmed.ncbi.nlm.nih.gov/34391547/

Messner CB, Demichev V, Bloomfield N, Yu JSL, White M, Kreidl M, Egger AS, Freiwald A, Ivosev G, Wasim F, Zelezniak A, Jürgens L, Suttorp N, Sander LE, Kurth F, Lilley KS, Mülleder M, Tate S, Ralser M.

Ultra-fast proteomics with Scanning SWATH.

Nat Biotechnol. 2021 Mar 25. doi: 10.1038/s41587-021-00860-4. Online ahead of print. PMID: 33767396. pubmed.ncbi.nlm.nih.gov/33767396/

Doehn JM, Tabeling C, Biesen R, Saccomanno J, Madlung E, Pappe E, Gabriel F, Kurth F, Meisel C, Corman VM, Hanitsch LG, Treskatsch S, Heim K, Stegemann MS, Ruwwe-Glösenkamp C, Müller-Redetzky HC, Uhrig A, Somasundaram R, Spies C, von Bernuth H, Hofmann J, Drosten C, Suttorp N, Witzenrath M, Sander LE, Hübner RH.

CD169/SIGLEC1 is expressed on circulating monocytes in COVID-19 and expression levels are associated with disease severity

Infection. 2021 Apr 6:1–6. doi: 10.1007/s15010-021-01606-9. Epub ahead of print. PMID: 33825125; PMCID: PMC8023546. pubmed.ncbi.nlm.nih.gov/33825125/

Michalick L, Weidenfeld S, Grimmer B, Fatykhova D, Solymosi PD, Behrens F, Dohmen M, Brack MC, Schulz S, Thomasch E, Simmons S, Müller-Redetzky H, Suttorp N, Kurth F, Neudecker J, Toennies M, Bauer TT, Eggeling S, Corman VM, Hocke AC, Witzenrath M, Hippenstiel S, Kuebler WM.

Plasma mediators in patients with severe COVID-19 cause lung endothelial barrier failure

Eur Respir J. 2020 Nov 5;2002384. doi: 10.1183/13993003.02384-2020. Online ahead of print.

Kreye J, Reincke SM, Kornau HC, Sanchez-Sendin E, Corman VM, Liu H, Yuan M, Wu NC, Zhu X, Lee CD, Trimpert J, Hoeltje M, Dietert K, Stoeffler L, von Wardenburg N, van Hoof S, Homeyer MA, Hoffmann J, Abdelgawad A, Gruber AD, Bertzbach LD, Vladimirova D, Li LY, Barthel PC, Skriner K, Hocke AC, Hippenstiel S, Witzenrath M, Suttorp N, Kurth F, Franke C, Endres M, Schmitz D, Jeworowski LM, Richter A, Schmidt ML, Schwarz T, Mueller MA, Drosten C, Wendisch D, Sander LE, Osterrieder N, Wilson IA, Pruess H.

A therapeutic non-self-reactive SARS-CoV-2 antibody protects from lung pathology in a COVID-19 hamster model.

CELL 11649

Schulte-Schrepping J, Reusch N, Paclik D, Baßler K, Schlickeiser S, Zhang B, Krämer B, Krammer T, Brumhard S, Bonaguro L, De Domenico E, Wendisch D, Grasshoff M, Kapellos TS, Beckstette M, Pecht T, Saglam A, Dietrich O, Mei HE, Schulz AR, Conrad C, Kunkel D, Vafadarnejad E, Xu C-J, Horne A, Herbert M, Drews A, Thibeault C, Pfeiffer M, Hippenstiel S, Hocke A, Müller-Redetzky H, Heim K-M, Machleidt F, Uhrig A, Bosquillon de Jarcy L, Jürgens L, Stegemann M, Glösenkamp CR, Volk H-D, Goffinet C, Landthaler M, Wyler E, Georg P, Schneider M, Dang-Heine C, Neuwinger N, Kappert K, Tauber R, Corman V, Raabe J, Kaiser KM, To Vinh M, Rieke G, Meisel C, Ulas T, Becker M, Geffers R, Witzenrath M, Drosten C, Suttorp N, von Kalle C, Kurth F, Händler K, Schultze JL, Aschenbrenner AC, Li Y, Nattermann J, Sawitzki B, Saliba A-E, Sander LE

Severe COVID-19 is marked by a dysregulated myeloid cell compartment

Cell. 2020 Aug 5;S0092-8674(20)30992-2

Braun J , Loyal L, Frentsch M, Wendisch D , Georg P , Kurth F , Hippenstiel S, Dingeldey M, Kruse B, Fauchere F, Baysal E, Mangold M, Henze L, Lauster R, Mall MA, Beyer K, Röhmel J, Voigt S, Schmitz J, Miltenyi S, Demuth I, Müller MA, Hocke A, Witzenrath M, Suttorp N, Kern F, Reimer U, Wenschuh H, Drosten C, Corman VM, Giesecke-Thiel C, Sander LE, Thiel A

SARS-CoV-2-reactive T cells in healthy donors and patients with COVID-19

Nature. 2020 Jul 29. doi: 10.1038/s41586-020-2598-9

Messner CB, Demichev V, Wendisch D, Michalick L, White M, Freiwald A, Textoris-Taube K, Vernardis SI, Egger AS, Kreidl M, Ludwig D, Kilian C, Agostini F, Zelezniak A, Thibeault C, Pfeiffer M, Hippenstiel S, Hocke A, von Kalle C, Campbell A, Hayward C, Porteous DJ, Marioni RE, Langenberg C, Lilley KS, Kuebler WM, Mülleder M, Drosten C, Suttorp N, Witzenrath M, Kurth F, Sander LE, Ralser M

Ultra-High-Throughput Clinical Proteomics Reveals Classifiers of COVID-19 Infection

Cell Syst. 2020 Jul 22;11(1):11-24.e4.

Lorenz Chua R, Lukassen Soeren, Trump S, Hennig BP, Wendisch D, Pott F, Debnath O, Thürmann L, Kurth F, Völker MT, Kazmierski Julia, Timmermann B, Twardziok S, Schneider S, Machleidt F, Müller-Redetzky H , Maier M, Krannich A, Schmidt S, Balzer F, Liebig J, Loske J, Suttorp N, Eils J, Ishaque N, Liebert UG, von Kalle C, Hocke A, Witzenrath M, Goffinet C, Drosten C, Laudi S, Lehmann I, Conrad C, Sander LE, Eils R

COVID-19 severity correlates with airway epithelium-immune cell interactions identified by single-cell analysis

Nat Biotechnol. 2020 Aug;38(8):970-979

Kurth F, Roennefarth M, Thibeault C, Corman VM, Müller-Redetzky H, Mittermaier M, Ruwwe-Glösenkamp C, Heim KM, Krannich A, Zvorc S, Schmidt S, Kretzler L, Dang-Heine C, Rose M, Hummel M, Hocke A, Hübner RH, Opitz B, Mall MA, Röhmel J, Landmesser U, Pieske B, Knauss S, Endres M, Spranger J, Mockenhaupt FP, Tacke F, Treskatsch S, Angermair S, Siegmund B, Spies C, Weber-Carstens S, Eckardt KU, Schürmann D, Uhrig A, Stegemann MS, Zoller T, Drosten C, Suttorp N, Witzenrath M, Hippenstiel S, von Kalle C, Sander LE.

Studying the pathophysiology of coronavirus disease 2019: a protocol for the Berlin prospective COVID-19 patient cohort (Pa-COVID-19).

Infection. 2020 Aug;48(4):619-626.

Lauster D, Klenk S, Ludwig K, Nojoumi S, Behren S, Adam L, Stadtmüller M, Saenger S, Zimmler S, Hönzke K, Yao L, Hoffmann U, Bardua M, Hamann A, Witzenrath M, Sander LE, Wolff T, Hocke AC, Hippenstiel S, De Carlo S, Neudecker J, Osterrieder K, Budisa N, Netz RR, Böttcher C, Liese S, Herrmann A, Hackenberger CPR

Phage capsid nanoparticles with defined ligand arrangement block influenza virus entry

Nat Nanotechnol. 2020 May;15(5):373-379

Herold S and Sander LE.

Toward a universal flu vaccine.

Science 367: 852-853, 2020.

Robak OH, Heimesaat MM, Kruglov AA, Prepens S, Ninnemann J, Gutbier B, Reppe K, Hochrein H, Suter M, Kirschning CJ, Marathe V, Buer J, Hornef MW, Schnare M, Schneider P, Witzenrath M, Bereswill S, Steinhoff U, Suttorp N, Sander LE, Chaput C, Opitz B

Antibiotic treatment-induced secondary IgA deficiency enhances susceptibility to Pseudomonas aeruginosa pneumonia.

J Clin Invest. 2018 Jul 16. pii: 97065

https://www.jci.org/articles/view/97065

Schumann B, Reppe K, Kaplonek P, Wahlbrink A, Anish C, Witzenrath M, Pereira CL, Seeberger PH

Development of an Efficacious, Semisynthetic Glycoconjugate Vaccine Candidate against Streptococcus pneumoniae Serotype 1.

ACS Cent Sci. 2018 4,357-361.

https://www.ncbi.nlm.nih.gov/pubmed/29632881

Barbet G, Sander LE, Geswell M, Leonardi I, Cerutti A, Iliev I, Blander JM

Sensing Microbial Viability through Bacterial RNA Augments T Follicular Helper Cell and Antibody Responses.

Immunity 2018;48(3):584-598.e5

http://www.cell.com/immunity/pdfExtended/S1074-7613(18)30074-8

Ugolini M, Gerhard J, Burkert S, Jensen KJ, Georg P, Ebner F, Thada S, Dietert K, Helbig ET, Opitz B, Kurth F, Dittrich N, Sumanlatha G, Blander JM, Gruber AD, Hartmann S, Boekschoten MV, Suttorp N, Müller M, Jungersen G, Schumann RR, Sander LE

Recognition of microbial viability via TLR8 promotes T follicular helper cell differentiation and vaccine responses.

Nat Immunol  2018

https://www.nature.com/articles/s41590-018-0068-4

Ruiz-Moreno JS, Hamann L, Jin L, Sander LE, Puzianowska-Kuznickad M, Cambier JC, Witzenrath M, Schumann RR, Suttorp N, Opitz B, CAPNETZ Study Group

The cGAS/STING pathway detects Streptococcus pneumoniae but is dispensable for anti-pneumococcal defense in mice and humans.

Infect Immun. 2017 Dec 20. pii: IAI.00849-17

http://iai.asm.org/content/early/2017/12/13/IAI.00849-17.abstract

Dietert K, Gutbier B, Wienhold SM, Reppe K, Jiang X, Yao L, Chaput C, Naujoks J, Brack M, Kupke A, Peteranderl C, Becker S, von Lachner C, Baal N, Slevogt H, Hocke AC, Witzenrath M, Opitz B, Herold S, Hackstein H, Sander LE, Suttorp N, Gruber AD

Spectrum of pathogen- and model-specific histopathologies in mouse models of acute pneumonia.

PLoS One. 2017 Nov 20;12(11):e0188251

https://www.ncbi.nlm.nih.gov/pubmed/29155867

Emmadi M, Khan N, Lykke L, Reppe K, Parameswarappa S, Lisboa MP, Wienhold SM, Witzenrath M, Pereira CL, Seeberger PH

A Streptococcus pneumoniae type 2 oligosaccharide glycoconjugate elicits opsonic antibodies and is protective in an animal model of invasive pneumococcal disease.

J Am Chem Soc 2017 Oct 4 [Epub ahead of print]

https://www.ncbi.nlm.nih.gov/pubmed/28945368

Lisboa MP, Khan N, Martin C, Xu FF, Reppe K, Geissner A, Govindan S, Witzenrath M, Pereira CL, Seeberger PH

Semisynthetic glycoconjugate vaccine candidate against Streptococcus pneumoniae serotype 5.

Proc Natl Acad Sci USA 2017 Oct 2 [Epub ahead of print]

https://www.ncbi.nlm.nih.gov/pubmed/28973947

Seeberger PH, Pereira CL, Khan N, Xiao G, Diago-Navarro E, Reppe K, Opitz B, Fries BC, Witzenrath M

A semi-synthetic glycoconjugate vaccine candidate for carbapenem-resistant Klebsiella pneumoniae.

Angew Chem Int Ed Engl. 2017 Aug 16

https://www.pubmed.de/gateway/nlm-pubmed/28815890

Hahm HS, Schlegel MK, Hurevich M, Eller S, Schuhmacher F, Hofmann J, Pagel K, and Seeberger PH

Automated glycan assembly using the Glyconeer 2.1 synthesizer.

Proc Natl Acad Sci U S A 114: E3385-E3389, 2017

https://www.ncbi.nlm.nih.gov/pubmed/28396442

Schumann B, Hahm HS, Parameswarappa SG, Reppe K, Wahlbrink A, Govindan S, Kaplonek P, Pirofski LA, Witzenrath M, Anish C, Pereira CL, Seeberger PH

A semisynthetic Streptococcus pneumoniae serotype 8 glycoconjugate vaccine.

Sci Transl Med. 2017 Mar 8;9(380)

https://www.ncbi.nlm.nih.gov/pubmed/28275152

Druzd D, Matveeva O, Ince L, Harrison U, He W, Schmal C, Herzel H, Tsang AH, Kawakami N, Leliavski A, Uhl O, Yao L, Sander LE, Chen CS, Kraus K, de Juan A, Hergenhan SM, Ehlers M, Koletzko B, Haas R, Solbach W, Oster H, Scheiermann C

Lymphocyte Circadian Clocks Control Lymph Node Trafficking and Adaptive Immune Responses.

Immunity. 2017 Jan 17;46(1):120-132

http://www.sciencedirect.com/science/article/pii/S1074761316305179

Parameswarappa SG, Reppe K, Geissner A, Ménová P, Govindan S, Calow AD, Wahlbrink A, Weishaupt MW, Monnanda BP, Bell RL, Pirofski LA, Suttorp N, Sander LE, Witzenrath M, Pereira CL, Anish C, Seeberger PH

A Semi-synthetic Oligosaccharide Conjugate Vaccine Candidate Confers Protection against Streptococcus pneumoniae Serotype 3 Infection.

Cell Chem Biol. 2016 Nov 2. pii: S2451-9456(16)30356-7

https://www.ncbi.nlm.nih.gov/pubmed/27818299

Garaude J, Acín-Pérez R, Martínez-Cano S, Enamorado M, Ugolini M, Nistal-Villán E, Hervás-Stubbs S, Pelegrín P, Sander LE, Enríquez JA, Sancho D

Mitochondrial respiratory-chain adaptations in macrophages contribute to antibacterial host defense.

Nat Immunol. 2016 Sep;17(9):1037-45

https://www.ncbi.nlm.nih.gov/pubmed/27348412

Kostadinova E, Chaput C, Gutbier B, Lippmann J, Sander LE, Mitchell TJ, Suttorp N, Witzenrath M, Opitz B

NLRP3 protects alveolar barrier integrity by an inflammasome-independent increase of epithelial cell adherence

Sci Rep. 2016 Aug 1;6:30943

https://www.ncbi.nlm.nih.gov/pubmed/27476670

Cavallari M, Stallforth P, Kalinichenko A, Rathwell DC, Gronewold TM, Adibekian A, Mori L, Landmann R, Seeberger PH

A semisynthetic carbohydrate-lipid vaccine that protects against S. pneumoniae in mice.

Nat Chem Biol. 2014 Nov;10(11):950-6