Publications
Pennitz P, Kirsten H, Friedrich VD, Wyler E, Goekeri C, Obermayer B, Heinz GA, Mashreghi MF, Büttner M, Trimpert J, Landthaler M, Suttorp N, Hocke AC, Hippenstiel S, Tönnies M, Scholz M, Kuebler WM, Witzenrath M, Hoenzke K, Nouailles G.
A pulmonologist's guide to perform and analyse cross-species single lung cell transcriptomics
Eur Respir Rev. 2022 Jul 27;31(165):220056. doi: 10.1183/16000617.0056-2022. https://pubmed.ncbi.nlm.nih.gov/35896273/
Hollenhorst MI, Nandigama R, Evers SB, Gamayun I, Abdel Wadood N, Salah A, Pieper M, Wyatt A, Stukalov A, Gebhardt A, Nadolni W, Burow W, Herr C, Beisswenger C, Kusumakshi S, Ectors F, Kichko TI, Hübner L, Reeh P, Munder A, Wienhold SM, Witzenrath M, Bals R, Flockerzi V, Gudermann T, Bischoff M, Lipp P, Zierler S, Chubanov V, Pichlmair A, König P, Boehm U, Krasteva-Christ G.
Bitter taste signaling in tracheal epithelial brush cells elicits innate immune responses to bacterial infection.
J Clin Invest. 2022; 132(13):e150951. https://pubmed.ncbi.nlm.nih.gov/35503420/
Tabeling C, González Calera CR, Lienau J, Höppner J, Tschernig T, Kershaw O, Gutbier B, Naujoks J, Herbert J, Opitz B, Gruber AD, Hocher B, Suttorp N, Heidecke H, Burmester GR, Riemekasten G, Siegert E, Kuebler WM, Witzenrath M.
Endothelin B Receptor Immunodynamics in Pulmonary Arterial Hypertension.
Front Immunol. 2022 Jun 9;13:895501. https://pubmed.ncbi.nlm.nih.gov/35757687/
Dannebaum R, Suwalski P, Asgharian H, Du Zhipei G, Lin H, Weiner J, Holtgrewe M, Thibeault C, Müller M, Wang X, Karadeniz Z, Saccomanno J, Doehn JM, Hübner RH, Hinzmann B, Blüher A, Siemann S, Telman D, Suttorp N, Witzenrath M, Hippenstiel S, Skurk C, Poller W, Sander LE, Beule D, Kurth F, Guettouche T, Landmesser U, Berka J, Luong K; Pa-COVID Study Group, Rubelt F, Heidecker B.
Highly multiplexed immune repertoire sequencing links multiple lymphocyte classes with severity of response to COVID-19.
EClinicalMedicine. 2022 Jun;48:101438. https://pubmed.ncbi.nlm.nih.gov/35600330/
Wyler E, Adler JM, Eschke K, Teixeira Alves G, Peidli S, Pott F, Kazmierski J, Michalick L, Kershaw O, Bushe J, Andreotti S, Pennitz P, Abdelgawad A, Postmus D, Goffinet C, Kreye J, Reincke SM, Prüss H, Blüthgen N, Gruber AD, Kuebler WM, Witzenrath M, Landthaler M, Nouailles G, Trimpert J.
Key benefits of dexamethasone and antibody treatment in COVID-19 hamster models revealed by single-cell transcriptomics
Mol Ther. 2022 May 4;30(5):1952-1965. doi: 10.1016/j.ymthe.2022.03.014. Epub 2022 Mar 24. https://pubmed.ncbi.nlm.nih.gov/35339689/
Lingscheid T, Lippert LJ, Hillus D, Kruis T, Thibeault C, Helbig ET, Tober-Lau P, Pfäfflin F, Müller-Redetzky H, Witzenrath M, Zoller T, Uhrig A, Opitz B, Suttorp N, Kramer TS, Sander LE, Stegemann MS, Kurth F.
Characterization of antimicrobial use and co-infections among hospitalized patients with COVID-19: a prospective observational cohort study.
Infection. 2022 Apr 14:1-12. https://pubmed.ncbi.nlm.nih.gov/35420370/
Kaplonek P, Yao L, Reppe K, Voß F, Kohler T, Ebner F, Schäfer A, Blohm U, Priegue P, Bräutigam M, Pereira CL, Parameswarappa SG, Emmadi M, Ménová P, Witzenrath M, Hammerschmidt S, Hartmann S, Sander LE, Seeberger PH.
A semisynthetic glycoconjugate provides expanded cross-serotype protection against Streptococcus pneumoniae
Vaccine. 2022 Feb 11;40(7):1038-1046. doi: 10.1016/j.vaccine.2021.12.068. Epub 2022 Jan 13. pubmed.ncbi.nlm.nih.gov/35033388/
Wygrecka M, Birnhuber A, Seeliger B, Michalick L, Pak O, Schultz AS, Schramm F, Zacharias M, Gorkiewicz G, David S, Welte T, Schmidt JJ, Weissmann N, Schermuly RT, Barreto G, Schaefer L, Markart P, Brack MC, Hippenstiel S, Kurth F, Sander LE, Witzenrath M, Kuebler WM, Kwapiszewska G, Preissner KT.
Altered fibrin clot structure and dysregulated fibrinolysis contribute to thrombosis risk in severe COVID-19
Blood Adv. 2022 Feb 8;6(3):1074-1087. doi: 10.1182/bloodadvances.2021004816. pubmed.ncbi.nlm.nih.gov/34861681/
Bahrs C, Kesselmeier M, Kolditz M, Ewig S, Rohde G, Barten-Neiner G, Rupp J, Witzenrath M, Welte T, Pletz MW; CAPNETZ Study Group.
A longitudinal analysis of pneumococcal vaccine serotypes in pneumonia patients in Germany
Eur Respir J. 2022 Feb 3;59(2):2102432. doi: 10.1183/13993003.02432-2021. Print 2022 Feb. https://pubmed.ncbi.nlm.nih.gov/34824055/
Kühnapfel A, Horn K, Klotz U, Kiehntopf M, Rosolowski M, Loeffler M, Ahnert P, Suttorp N, Witzenrath M, Scholz M.
Genetic Regulation of Cytokine Response in Patients with Acute Community-Acquired Pneumonia.
Genes (Basel). 2022 Jan 6;13(1):111. https://pubmed.ncbi.nlm.nih.gov/35052452/
Wienhold SM, Brack MC, Nouailles G, Krishnamoorthy G, Korf IHE, Seitz C, Wienecke S, Dietert K, Gurtner C, Kershaw O, Gruber AD, Ross A, Ziehr H, Rohde M, Neudecker J, Lienau J, Suttorp N, Hippenstiel S, Hocke AC, Rohde C, Witzenrath M.
Preclinical Assessment of Bacteriophage Therapy against Experimental Acinetobacter baumannii Lung Infection.
Viruses. 2021 Dec 24;14(1):33. https://pubmed.ncbi.nlm.nih.gov/35062236/
Letsiou E, Teixeira Alves LG, Felten M, Mitchell TJ, Müller-Redetzky HC, Dudek SM, Witzenrath M.
Neutrophil-Derived Extracellular Vesicles Activate Platelets after Pneumolysin Exposure.
Cells. 2021;10(12):3581. https://pubmed.ncbi.nlm.nih.gov/34944089/
Steinbeis F, Thibeault C, Doellinger F, Ring RM, Mittermaier M, Ruwwe-Glösenkamp C, Alius F, Knape P, Meyer HJ, Lippert LJ, Helbig ET, Grund D, Temmesfeld-Wollbrück B, Suttorp N, Sander LE, Kurth F, Penzkofer T, Witzenrath M, Zoller T.
Severity of respiratory failure and computed chest tomography in acute COVID-19 correlates with pulmonary function and respiratory symptoms after infection with SARS-CoV-2: An observational longitudinal study over 12 months.
Respir Med. 2021 Dec 1;191:106709. doi: 10.1016/j.rmed.2021.106709. Epub ahead of print. PMID: 34871947; PMCID: PMC8632363. pubmed.ncbi.nlm.nih.gov/34871947/
Wendisch D, Dietrich O, Mari T, von Stillfried S, Ibarra IL, Mittermaier M, Mache C, Chua RL, Knoll R, Timm S, Brumhard S, Krammer T, Zauber H, Hiller AL, Pascual-Reguant A, Mothes R, Bülow RD, Schulze J, Leipold AM, Djudjaj S, Erhard F, Geffers R, Pott F, Kazmierski J, Radke J, Pergantis P, Baßler K, Conrad C, Aschenbrenner AC, Sawitzki B, Landthaler M, Wyler E, Horst D; Deutsche COVID-19 OMICS Initiative (DeCOI), Hippenstiel S, Hocke A, Heppner FL, Uhrig A, Garcia C, Machleidt F, Herold S, Elezkurtaj S, Thibeault C, Witzenrath M, Cochain C, Suttorp N, Drosten C, Goffinet C, Kurth F, Schultze JL, Radbruch H, Ochs M, Eils R, Müller-Redetzky H, Hauser AE, Luecken MD, Theis FJ, Conrad C, Wolff T, Boor P, Selbach M, Saliba AE, Sander LE.
SARS-CoV-2 infection triggers profibrotic macrophage responses and lung fibrosis.
Cell. 2021 Nov 27:S0092-8674(21)01383-0. doi: 10.1016/j.cell.2021.11.033. Epub ahead of print. PMID: 34914922. pubmed.ncbi.nlm.nih.gov/34914922/
Weiner J, Suwalski P, Holtgrewe M, Rakitko A, Thibeault C, Müller M, Patriki D, Quedenau C, Krüger U, Ilinsky V, Popov I, Balnis J, Jaitovich A, Helbig ET, Lippert LJ, Stubbemann P, Real LM, Macías J, Pineda JA, Fernandez-Fuertes M, Wang X, Karadeniz Z, Saccomanno J, Doehn JM, Hübner RH, Hinzmann B, Salvo M, Blueher A, Siemann S, Jurisic S, Beer JH, Rutishauser J, Wiggli B, Schmid H, Danninger K, Binder R, Corman VM, Mühlemann B, Arjun Arkal R, Fragiadakis GK, Mick E, Comet C, Calfee CS, Erle DJ, Hendrickson CM, Kangelaris KN, Krummel MF, Woodruff PG, Langelier CR, Venkataramani U, García F, Zyla J, Drosten C, Alice B, Jones TC, Suttorp N, Witzenrath M, Hippenstiel S, Zemojtel T, Skurk C, Poller W, Borodina T, Pa-Covid SG, Ripke S, Sander LE, Beule D, Landmesser U, Guettouche T, Kurth F, Heidecker B.
Increased risk of severe clinical course of COVID-19 in carriers of HLA-C*04:01
EClinicalMedicine. 2021 Oct;40:101099. doi: 10.1016/j.eclinm.2021.101099. Epub 2021 Sep 2. PMID: 34490415; PMCID: PMC8410317. pubmed.ncbi.nlm.nih.gov/34490415/
Jagdmann S, Berchtold D, Gutbier B, Witzenrath M, Meisel A, Meisel C, Dames C
Efficacy and safety of intratracheal IFN-γ treatment to reverse stroke-induced susceptibility to pulmonary bacterial infections
J Neuroimmunol. 2021 Jun 15;355:577568. doi: 10.1016/j.jneuroim.2021.577568. Epub 2021 Apr 3. PMID: 33862420. pubmed.ncbi.nlm.nih.gov/33862420/
Demichev V, Tober-Lau P, Lemke O, Nazarenko T, Thibeault C, Whitwell H, Röhl A, Freiwald A, Szyrwiel L, Ludwig D, Correia-Melo C, Aulakh SK, Helbig ET, Stubbemann P, Lippert LJ, Grüning NM, Blyuss O, Vernardis S, White M, Messner CB, Joannidis M, Sonnweber T, Klein SJ, Pizzini A, Wohlfarter Y, Sahanic S, Hilbe R, Schaefer B, Wagner S, Mittermaier M, Machleidt F, Garcia C, Ruwwe-Glösenkamp C, Lingscheid T, Bosquillon de Jarcy L, Stegemann MS, Pfeiffer M, Jürgens L, Denker S, Zickler D, Enghard P, Zelezniak A, Campbell A, Hayward C, Porteous DJ, Marioni RE, Uhrig A, Müller-Redetzky H, Zoller H, Löffler-Ragg J, Keller MA, Tancevski I, Timms JF, Zaikin A, Hippenstiel S, Ramharter M, Witzenrath M, Suttorp N, Lilley K, Mülleder M, Sander LE; PA-COVID-19 Study group, Ralser M, Kurth F.
A time-resolved proteomic and prognostic map of COVID-19
Cell Syst. 2021 Jun 14:S2405-4712(21)00160-5. doi: 10.1016/j.cels.2021.05.005. Epub ahead of print. PMID: 34139154; PMCID: PMC8201874. pubmed.ncbi.nlm.nih.gov/34139154/
Witzenrath M, Kuebler WM.
The CypA-netics of Ventilator-Induced Lung Injury
Am J Respir Crit Care Med. 2021 May 25. doi: 10.1164/rccm.202104-0919ED. Epub ahead of print. PMID: 34033522. pubmed.ncbi.nlm.nih.gov/34033522/
Letsiou E, Teixeira Alves LG, Fatykhova D, Felten M, Mitchell TJ, Müller-Redetzky HC, Hocke AC, Witzenrath M.
Microvesicles released from pneumolysin-stimulated lung epithelial cells carry mitochondrial cargo and suppress neutrophil oxidative burst
Sci Rep. 2021 May 5;11(1):9529. doi: 10.1038/s41598-021-88897-y. PMID: 33953279; PMCID: PMC8100145. pubmed.ncbi.nlm.nih.gov/33953279/
Hadzibegovic S, Lena A, Churchill TW, Ho JE, Potthoff S, Denecke C, Rösnick L, Heim KM, Kleinschmidt M, Sander LE, Witzenrath M, Suttorp N, Krannich A, Porthun J, Friede T, Butler J, Wilkenshoff U, Pieske B, Landmesser U, Anker SD, Lewis GD, Tschöpe C, Anker MS.
Heart failure with preserved ejection fraction according to the HFA-PEFF score in COVID-19 patients: clinical correlates and echocardiographic findings
Eur J Heart Fail. 2021 May 1:10.1002/ejhf.2210. doi: 10.1002/ejhf.2210. Epub ahead of print. PMID: 33932255; PMCID: PMC8239668. pubmed.ncbi.nlm.nih.gov/33932255/
Doehn JM, Tabeling C, Biesen R, Saccomanno J, Madlung E, Pappe E, Gabriel F, Kurth F, Meisel C, Corman VM, Hanitsch LG, Treskatsch S, Heim K, Stegemann MS, Ruwwe-Glösenkamp C, Müller-Redetzky HC, Uhrig A, Somasundaram R, Spies C, von Bernuth H, Hofmann J, Drosten C, Suttorp N, Witzenrath M, Sander LE, Hübner RH.
CD169/SIGLEC1 is expressed on circulating monocytes in COVID-19 and expression levels are associated with disease severity
Infection. 2021 Apr 6:1–6. doi: 10.1007/s15010-021-01606-9. Epub ahead of print. PMID: 33825125; PMCID: PMC8023546. pubmed.ncbi.nlm.nih.gov/33825125/
Tabeling C, Wienhold SM, Birnhuber A, Brack MC, Nouailles G, Kershaw O, Firsching TC, Gruber AD, Lienau J, Marsh LM, Olschewski A, Kwapiszewska G, Witzenrath M.
Pulmonary fibrosis in Fra-2 transgenic mice is associated with decreased numbers of alveolar macrophages and increased susceptibility to pneumococcal pneumonia
Am J Physiol Lung Cell Mol Physiol. 2021 Mar 3. doi: 10.1152/ajplung.00505.2020. Epub ahead of print. PMID: 33655757. pubmed.ncbi.nlm.nih.gov/33655757/
Vlaar APJ, de Bruin S, Busch M, Timmermans SAMEG, van Zeggeren IE, Koning R, Ter Horst L, Bulle EB, van Baarle FEHP, van de Poll MCG, Kemper EM, van der Horst ICC, Schultz MJ, Horn J, Paulus F, Bos LD, Wiersinga WJ, Witzenrath M, Rueckinger S, Pilz K, Brouwer MC, Guo RF, Heunks L, van Paassen P, Riedemann NC, van de Beek D.
Anti-C5a antibody IFX-1 (vilobelimab) treatment versus best supportive care for patients with severe COVID-19 (PANAMO): an exploratory, open-label, phase 2 randomised controlled trial
Lancet Rheumato. 2020 Dec;2(12):e764-e773. doi: 10.1016/S2665-9913(20)30341-6.
Schirm S, Ahnert P, Berger S, Nouailles G, Wienhold SM, Müller-Redetzky H, Suttorp N, Loeffler M, Witzenrath M, Scholz M.
A biomathematical model of immune response and barrier function in mice with pneumococcal lung infection
PLoS One. 2020 Dec 3;15(12):e0243147. doi: 10.1371/journal.pone.0243147.
Michalick L, Weidenfeld S, Grimmer B, Fatykhova D, Solymosi PD, Behrens F, Dohmen M, Brack MC, Schulz S, Thomasch E, Simmons S, Müller-Redetzky H, Suttorp N, Kurth F, Neudecker J, Toennies M, Bauer TT, Eggeling S, Corman VM, Hocke AC, Witzenrath M, Hippenstiel S, Kuebler WM.
Plasma mediators in patients with severe COVID-19 cause lung endothelial barrier failure
Eur Respir J. 2020 Nov 5;2002384. doi: 10.1183/13993003.02384-2020. Online ahead of print.
Schulte-Schrepping J, Reusch N, Paclik D, Baßler K, Schlickeiser S, Zhang B, Krämer B, Krammer T, Brumhard S, Bonaguro L, De Domenico E, Wendisch D, Grasshoff M, Kapellos TS, Beckstette M, Pecht T, Saglam A, Dietrich O, Mei HE, Schulz AR, Conrad C, Kunkel D, Vafadarnejad E, Xu C-J, Horne A, Herbert M, Drews A, Thibeault C, Pfeiffer M, Hippenstiel S, Hocke A, Müller-Redetzky H, Heim K-M, Machleidt F, Uhrig A, Bosquillon de Jarcy L, Jürgens L, Stegemann M, Glösenkamp CR, Volk H-D, Goffinet C, Landthaler M, Wyler E, Georg P, Schneider M, Dang-Heine C, Neuwinger N, Kappert K, Tauber R, Corman V, Raabe J, Kaiser KM, To Vinh M, Rieke G, Meisel C, Ulas T, Becker M, Geffers R, Witzenrath M, Drosten C, Suttorp N, von Kalle C, Kurth F, Händler K, Schultze JL, Aschenbrenner AC, Li Y, Nattermann J, Sawitzki B, Saliba A-E, Sander LE
Severe COVID-19 is marked by a dysregulated myeloid cell compartment
Braun J , Loyal L, Frentsch M, Wendisch D , Georg P , Kurth F , Hippenstiel S, Dingeldey M, Kruse B, Fauchere F, Baysal E, Mangold M, Henze L, Lauster R, Mall MA, Beyer K, Röhmel J, Voigt S, Schmitz J, Miltenyi S, Demuth I, Müller MA, Hocke A, Witzenrath M, Suttorp N, Kern F, Reimer U, Wenschuh H, Drosten C, Corman VM, Giesecke-Thiel C, Sander LE, Thiel A
SARS-CoV-2-reactive T cells in healthy donors and patients with COVID-19
Messner CB, Demichev V, Wendisch D, Michalick L, White M, Freiwald A, Textoris-Taube K, Vernardis SI, Egger AS, Kreidl M, Ludwig D, Kilian C, Agostini F, Zelezniak A, Thibeault C, Pfeiffer M, Hippenstiel S, Hocke A, von Kalle C, Campbell A, Hayward C, Porteous DJ, Marioni RE, Langenberg C, Lilley KS, Kuebler WM, Mülleder M, Drosten C, Suttorp N, Witzenrath M, Kurth F, Sander LE, Ralser M
Ultra-High-Throughput Clinical Proteomics Reveals Classifiers of COVID-19 Infection
Lorenz Chua R, Lukassen Soeren, Trump S, Hennig BP, Wendisch D, Pott F, Debnath O, Thürmann L, Kurth F, Völker MT, Kazmierski Julia, Timmermann B, Twardziok S, Schneider S, Machleidt F, Müller-Redetzky H , Maier M, Krannich A, Schmidt S, Balzer F, Liebig J, Loske J, Suttorp N, Eils J, Ishaque N, Liebert UG, von Kalle C, Hocke A, Witzenrath M, Goffinet C, Drosten C, Laudi S, Lehmann I, Conrad C, Sander LE, Eils R
COVID-19 severity correlates with airway epithelium-immune cell interactions identified by single-cell analysis
Kurth F, Roennefarth M, Thibeault C, Corman VM, Müller-Redetzky H, Mittermaier M, Ruwwe-Glösenkamp C, Heim KM, Krannich A, Zvorc S, Schmidt S, Kretzler L, Dang-Heine C, Rose M, Hummel M, Hocke A, Hübner RH, Opitz B, Mall MA, Röhmel J, Landmesser U, Pieske B, Knauss S, Endres M, Spranger J, Mockenhaupt FP, Tacke F, Treskatsch S, Angermair S, Siegmund B, Spies C, Weber-Carstens S, Eckardt KU, Schürmann D, Uhrig A, Stegemann MS, Zoller T, Drosten C, Suttorp N, Witzenrath M, Hippenstiel S, von Kalle C, Sander LE.
Studying the pathophysiology of coronavirus disease 2019: a protocol for the Berlin prospective COVID-19 patient cohort (Pa-COVID-19).
Ochs M, Hegermann J, Lopez-Rodriguez E, Timm S, Nouailles G, Matuszak J, Simmons S, Witzenrath M, Kuebler WM.
On Top of the Alveolar Epithelium: Surfactant and the Glycocalyx
Int J Mol Sci. 2020 Apr 27;21(9):3075. doi: 10.3390/ijms21093075.
Müller-Redetzky H, Kellermann U, Wienhold SM, Gutbier B, Lienau J, Hellwig K, Reppe K, Letsiou E, Tschernig T, Scholz M, Ahnert P, Maasch C, Hoehlig K, Klussmann S, Vater A, Firsching TC, Hoppe J, Suttorp N, Witzenrath M.
Neutralizing Complement C5a Protects Mice with Pneumococcal Pulmonary Sepsis
Sodemann EB, Dähling S, Klopfleisch R, Boiarina E, Cataldo D, Alhasan MM, Yildirim AÖ, Witzenrath M, Tabeling C, Conrad ML.
Maternal asthma is associated with persistent changes in allergic offspring antibody glycosylation
Clin Exp Allergy. 2020 Apr;50(4):520-531. doi: 10.1111/cea.13559.
Lauster D, Klenk S, Ludwig K, Nojoumi S, Behren S, Adam L, Stadtmüller M, Saenger S, Zimmler S, Hönzke K, Yao L, Hoffmann U, Bardua M, Hamann A, Witzenrath M, Sander LE, Wolff T, Hocke AC, Hippenstiel S, De Carlo S, Neudecker J, Osterrieder K, Budisa N, Netz RR, Böttcher C, Liese S, Herrmann A, Hackenberger CPR
Phage capsid nanoparticles with defined ligand arrangement block influenza virus entry
Kaßmann M, Szijártó IA, García-Prieto CF, Fan G, Schleifenbaum J, Anistan YM, Tabeling C, Shi Y, le Noble F, Witzenrath M, Huang Y, Markó L, Nelson MT, Gollasch M.
Role of Ryanodine Type 2 Receptors in Elementary Ca2+ Signaling in Arteries and Vascular Adaptive Responses.
J Am Heart Assoc. 2019;8(9):e010090. https://pubmed.ncbi.nlm.nih.gov/31030596/
Brack MC, Lienau J, Kuebler WM, Witzenrath M.
Cardiovascular sequelae of pneumonia
Curr Opin Pulm Med. 2019 May;25(3):257-262. doi: 10.1097/MCP.0000000000000584.
Kaplonek P, Khan N, Reppe K, Schumann B, Emmadi M, Lisboa MP, Xu FF, Calow ADJ, Parameswarappa SG, Witzenrath M, Pereira CL, Seeberger PH.
Improving vaccines against Streptococcus pneumoniae using synthetic glycans.
Proc Natl Acad Sci U S A 2018;115(52):13353-13358. https://pubmed.ncbi.nlm.nih.gov/30530654/
Fischer K, Doehn JM, Herr C, Lachner C, Heinrich A, Kershaw O, Voss M, Jacobson MH, Gruber AD, Clauss M, Witzenrath M, Bals R, Gutbier B, Slevogt H.
Acute Moraxella catarrhalis infection of chronically smoke-exposed mice increases mechanisms of emphysema development: a pilot study.
Eur J Microbiol Immunol (Bp.) 2018;8(4):128-134. https://pubmed.ncbi.nlm.nih.gov/30719329/
Berger S, Gökeri C, Gupta SK, Vera J, Dietert K, Behrendt U, Lienau J, Wienhold SM, Gruber AD, Suttorp N, Witzenrath M*, Nouailles G*.
Delay in antibiotic therapy results in fatal disease outcome in murine pneumococcal pneumonia.
Crit Care 2018;22(1):287. https://pubmed.ncbi.nlm.nih.gov/30382866/
Wienhold SM, Macrì M, Nouailles G, Dietert K, Gurtner C, Gruber AD, Heimesaat MM, Lienau J, Schumacher F, Kleuser B, Opitz B, Suttorp N, Witzenrath M*, Müller-Redetzky HC*.
Ventilator-induced lung injury is aggravated by antibiotic mediated microbiota depletion in mice.
Crit Care. 2018;22(1):282. https://pubmed.ncbi.nlm.nih.gov/30373626/
Robak OH, Heimesaat MM, Kruglov AA, Prepens S, Ninnemann J, Gutbier B, Reppe K, Hochrein H, Suter M, Kirschning CJ, Marathe V, Buer J, Hornef MW, Schnare M, Schneider P, Witzenrath M, Bereswill S, Steinhoff U, Suttorp N, Sander LE, Chaput C, Opitz B
Antibiotic treatment-induced secondary IgA deficiency enhances susceptibility to Pseudomonas aeruginosa pneumonia.
J Clin Invest. 2018 Jul 16. pii: 97065
Szijarto IA, Marko L, Filipovic MR, Miljkovic JL, Tabeling C, Tsvetkov D, Wang N, Rabelo LA, Witzenrath M, Diedrich A, Tank J, Akahoshi N, Kamata S, Ishii I, Gollasch M.
Cystathionine gamma-Lyase-Produced Hydrogen Sulfide Controls Endothelial NO Bioavailability and Blood Pressure.
Hypertension. 2018;71(6):1210-1217. https://pubmed.ncbi.nlm.nih.gov/29712741/
Erickson NA, Dietert K, Enders J, Glauben R, Nouailles G, Gruber AD, Mundhenk L
Soluble mucus component CLCA1 modulates expression of leukotactic cytokines and BPIFA1 in murine alveolar macrophages but not in bone marrow-derived macrophages.
Histochem Cell Biol. 2018 Apr 2. doi: 10.1007/s00418-018-1664-y
Schumann B, Reppe K, Kaplonek P, Wahlbrink A, Anish C, Witzenrath M, Pereira CL, Seeberger PH
Development of an Efficacious, Semisynthetic Glycoconjugate Vaccine Candidate against Streptococcus pneumoniae Serotype 1.
ACS Cent Sci. 2018 4,357-361.
Gutbier B, Neuhauß AK, Reppe K, Ehrler C, Santel A, Kaufmann J, Scholz M, Weissmann N, Morawietz L, Mitchell TJ, Aliberti S, Hippenstiel S, Suttorp N, Witzenrath M; CAPNETZ and PROGRESS study groups
Prognostic and Pathogenic Role of Angiopoietin-1 and -2 in Pneumonia.
Am J Respir Crit Care Med. 2018 Feb 15
Nerlich A, Mieth M, Letsiou E, Fatykhova D, Zscheppang K, Matsushima AI, Meyer TF, Paasch L, Mitchell T, Tönnies M, Bauer TT, Schneider P, Neudecker J, Rückert J, Eggeling S, Schimek M, Witzenrath M, Suttorp N, Hippenstiel S, Hocke AC
Pneumolysin induced mitochondrial dysfunction leads to release of mitochondrial DNA.
Scientific Reports (2018) 8:182
Ruiz-Moreno JS, Hamann L, Shah JA, Verbon A, Mockenhaupt FP, Puzianowska-Kuznicka M, Naujoks J, Sander LE, Witzenrath M, Cambier JC, Suttorp N, Schumann RR, Jin L, Hawn TR, Opitz B, CAPNETZ Study Group
The common HAQ STING variant impairs cGAS-dependent antibacterial responses and is associated with susceptibility to Legionnaires' disease in humans.
PLoS Pathog. 2018 Jan 3;14(1)
http://journals.plos.org/plospathogens/article?id=10.1371/journal.ppat.1006829
Gutbier B, Schönrock SM, Ehrler C, Haberberger R, Dietert K, Gruber AD, Kummer W, Michalik L, Kübler WM, Hocke AC, Szymanski K, Letsiou E, Lüth A, Schumacher F, Kleuser B, Mitchell TJ, Bertrams W, Schmeck B, Treue D, Klauschen F, Bauer TT, Tönnies M,
Sphingosine kinase 1 regulates inflammation and contributes to acute lung injury in pneumococcal pneumonia via the S1P receptor 2.
Crit Care Med. 2018 Jan 2.
Ruiz-Moreno JS, Hamann L, Jin L, Sander LE, Puzianowska-Kuznickad M, Cambier JC, Witzenrath M, Schumann RR, Suttorp N, Opitz B, CAPNETZ Study Group
The cGAS/STING pathway detects Streptococcus pneumoniae but is dispensable for anti-pneumococcal defense in mice and humans.
Infect Immun. 2017 Dec 20. pii: IAI.00849-17
http://iai.asm.org/content/early/2017/12/13/IAI.00849-17.abstract
Jensen AV, Faurholt-Jepsen D, Egelund GB, Andersen SB, Petersen PT, Benfield T, Witzenrath M, Rohde G, Ravn P; German Community-Acquired Pneumonia Competence Network (CAPNETZ)
Undiagnosed Diabetes Mellitus in Community-Acquired Pneumonia: A Prospective Cohort Study.
Clin Infect Dis. 2017 Nov 29;65(12):2091-2098
Dietert K, Gutbier B, Wienhold SM, Reppe K, Jiang X, Yao L, Chaput C, Naujoks J, Brack M, Kupke A, Peteranderl C, Becker S, von Lachner C, Baal N, Slevogt H, Hocke AC, Witzenrath M, Opitz B, Herold S, Hackstein H, Sander LE, Suttorp N, Gruber AD
Spectrum of pathogen- and model-specific histopathologies in mouse models of acute pneumonia.
PLoS One. 2017 Nov 20;12(11):e0188251
Gutbier B, Jiang X, Dietert K, Ehrler C, Lienau J, Van Slyke P, Kim H, Van Hoang C, Maynes JT, Dumont DJ, Gruber AD, Weissmann N, Mitchell TJ, Suttorp N, Witzenrath M
Vasculotide reduces pulmonary hyperpermeability in experimental pneumococcal pneumonia.
Critical Care 2017 Nov 13;21(1):274
Emmadi M, Khan N, Lykke L, Reppe K, Parameswarappa S, Lisboa MP, Wienhold SM, Witzenrath M, Pereira CL, Seeberger PH
A Streptococcus pneumoniae type 2 oligosaccharide glycoconjugate elicits opsonic antibodies and is protective in an animal model of invasive pneumococcal disease.
J Am Chem Soc 2017 Oct 4 [Epub ahead of print]
Lisboa MP, Khan N, Martin C, Xu FF, Reppe K, Geissner A, Govindan S, Witzenrath M, Pereira CL, Seeberger PH
Semisynthetic glycoconjugate vaccine candidate against Streptococcus pneumoniae serotype 5.
Proc Natl Acad Sci USA 2017 Oct 2 [Epub ahead of print]
Seeberger PH, Pereira CL, Khan N, Xiao G, Diago-Navarro E, Reppe K, Opitz B, Fries BC, Witzenrath M
A semi-synthetic glycoconjugate vaccine candidate for carbapenem-resistant Klebsiella pneumoniae.
Angew Chem Int Ed Engl. 2017 Aug 16
Wygrecka M, Kosanovic D, Wujak L, Reppe K, Henneke I, Frey H, Didiasova M, Kwapiszewska G, Marsh LM, Baal N, Hackstein H, Zakrzewicz D, Müller-Redetzky HC, de Maat S, Maas C, Nolte MW, Panousis C, Schermuly RT, Seeger W, Witzenrath M, Schaefer L, Markart
Antihistone Properties of C1 Esterase Inhibitor Protect against Lung Injury.
Am J Respir Crit Care Med. 2017 Jul 15;196(2):186-199
Tabeling C, Herbert J, Hocke AC, Lamb DJ, Wollin SL, Erb KJ, Boiarina E, Movassagh H, Scheffel J, Doehn JM, Hippenstiel S, Maurer M, Gounni AS, Kuebler WM, Suttorp N, Witzenrath M
Spleen tyrosine kinase inhibition blocks airway constriction and protects from Th2-induced airway inflammation and remodeling.
Allergy. 2017 Jul;72(7):1061-1072
Schumann B, Hahm HS, Parameswarappa SG, Reppe K, Wahlbrink A, Govindan S, Kaplonek P, Pirofski LA, Witzenrath M, Anish C, Pereira CL, Seeberger PH
A semisynthetic Streptococcus pneumoniae serotype 8 glycoconjugate vaccine.
Sci Transl Med. 2017 Mar 8;9(380)
Parameswarappa SG, Reppe K, Geissner A, Ménová P, Govindan S, Calow AD, Wahlbrink A, Weishaupt MW, Monnanda BP, Bell RL, Pirofski LA, Suttorp N, Sander LE, Witzenrath M, Pereira CL, Anish C, Seeberger PH
A Semi-synthetic Oligosaccharide Conjugate Vaccine Candidate Confers Protection against Streptococcus pneumoniae Serotype 3 Infection.
Cell Chem Biol. 2016 Nov 2. pii: S2451-9456(16)30356-7
Schaefer MB, Schaefer CA, Schifferings S, Kuhlmann CR, Urban A, Benscheid U, Fischer T, Hecker M, Morty RE, Vadasz I, Herold S, Witzenrath M, Seeger W, Erdogan A, Mayer K
N-3 vs. n-6 fatty acids differentially influence calcium signalling and adhesion of inflammatory activated monocytes: impact of lipid rafts.
Inflamm Res. 2016 Nov;65(11):881-894
Kostadinova E, Chaput C, Gutbier B, Lippmann J, Sander LE, Mitchell TJ, Suttorp N, Witzenrath M, Opitz B
NLRP3 protects alveolar barrier integrity by an inflammasome-independent increase of epithelial cell adherence
Sci Rep. 2016 Aug 1;6:30943
Tabeling C, Noe E, Naujoks J, Doehn JM, Hippenstiel S, Opitz B, Suttorp N, Klopfleisch R, Witzenrath M
PKCα Deficiency in Mice Is Associated with Pulmonary Vascular Hyperresponsiveness to Thromboxane A2 and Increased Thromboxane Receptor Expression.
J Vasc Res. 2015;52(4):279-88
Naujoks J, Tabeling C, Dill BD, Hoffmann C, Brown AS, Kunze M, Kempa S, Peter A, Mollenkopf HJ, Dorhoi A, Kershaw O, Gruber AD, Sander LE, Witzenrath M, Herold S, Nerlich A, Hocke AC, van Driel I, Suttorp N, Bedoui S, Hilbi H, Trost M, Opitz B
IFNs Modify the Proteome of Legionella-Containing Vacuoles and Restrict Infection Via IRG1-Derived Itaconic Acid.
PLoS Pathog. 2016 Feb 1;12(2)
Müller-Redetzky H, Lienau J, Suttorp N, Witzenrath M
Therapeutic strategies in pneumonia: going beyond antibiotics.
Eur Respir Rev. 2015 Sep;24(137):516-24
Gutbier B, Fischer K, Doehn JM, von Lachner C, Herr C, Klaile E, Frischmann U, Singer BB, Riesbeck K, Zimmermann W, Suttorp N, Bachmann S, Bals R, Witzenrath M, Slevogt H
Moraxella catarrhalis induces an immune response in the murine lung that is independent of human CEACAM5 expression and long-term smoke exposure.
Am J Physiol Lung Cell Mol Physiol. 2015 Aug 1;309(3):L250-61
Müller-Redetzky HC, Wienhold SM, Berg J, Hocke AC, Hippenstiel S, Hellwig K, Gutbier B, Opitz B, Neudecker J, Rückert J, Gruber AC, Kershaw O, Mayer K, Suttorp N, Witzenrath M
Moxifloxacin is not anti-inflammatory in experimental pneumococcal pneumonia.
J Antimicrob Chemother. 2015 Mar;70(3):830-40
Tabeling C, Yu H, Wang L, Ranke H, Goldenberg NM, Zabini D, Noe E, Krauszman A, Gutbier B, Yin J, Schaefer M, Arenz C, Hocke AC, Suttorp N, Proia RL, Witzenrath M, Kuebler WM
CFTR and sphingolipids mediate hypoxic pulmonary vasoconstriction.
Proc Natl Acad Sci U S A. 2015 Mar 31;112(13):E1614-23
Dietert K, Mundhenk L, Erickson NA, Reppe K, Hocke AC, Kummer W, Witzenrath M, Gruber AD
Murine CLCA5 is uniquely expressed in distinct niches of airway epithelial cells.
Histochem Cell Biol. 2015 Mar;143(3):277-87. doi: 10.1007/s00418-014-1279-x.
Müller-Redetzky HC, Felten M, Hellwig K, Wienhold SM, Naujoks J, Opitz B, Kershaw O, Gruber AD, Suttorp N, Witzenrath M
Increasing the inspiratory time and I:E ratio during mechanical ventilation aggravates ventilator-induced lung injury in mice.
Critical Care 2015, 19:23
Dames C, Akyüz L, Reppe K, Tabeling C, Dietert K, Kershaw O, Gruber AD, Meisel C, Meisel A, Witzenrath M, Engel O
Miniaturized bronchoscopy enables unilateral investigation, application, and sampling in mice.
Am J Respir Cell Mol Biol. 2014 Dec;51(6):730-7
Savai R, Al-Tamari HM, Sedding D, Kojonazarov B, Muecke C, Teske R, Capecchi MR, Weissmann N, Grimminger F, Seeger W, Schermuly RT, Pullamsetti SS
Pro-proliferative and inflammatory signaling converge on FoxO1 transcription factor in pulmonary hypertension.
Nat Med. 2014 Nov;20(11):1289-300
Noe E, Tabeling C, Doehn JM, Naujoks J, Opitz B, Hippenstiel S, Witzenrath M, Klopfleisch R
Juvenile megaesophagus in PKCα-deficient mice is associated with an increase in the segment of the distal esophagus lined by smooth muscle cells.
Ann Anat. 2014 Sep;196(5):365-71
Veith NT, Tschernig T, Gutbier B, Witzenrath M, Meier C, Menger M, Bischoff M
Surfactant protein A mediates pulmonary clearance of Staphylococcus aureus.
Respir Res. 2014 Aug 5;15:85
Heine G, Tabeling C, Hartmann B, González Calera CR, Kühl AA, Lindner J, Radbruch A, Witzenrath M, Worm M
25-hydroxvitamin D3 promotes the long-term effect of specific immunotherapy in a murine allergy model.
J Immunol. 2014 Aug 1;193(3)
Witzenrath M
Endothelial progenitor cells for acute respiratory distress syndrome treatment: support your local sheriff!
Am J Respir Crit Care Med. 2014 Jun 15;189(12):1452-5
Weissmann N, Peters DM, Klöpping C, Krüger K, Pilat C, Katta S, Seimetz M, Ghofrani HA, Schermuly RT, Witzenrath M, Seeger W, Grimminger F, Mooren FC
Structural and functional prevention of hypoxia-induced pulmonary hypertension by individualized exercise training in mice.
Am J Physiol Lung Cell Mol Physiol. 2014 Jun 1;306(11):L986-95
Tabeling C, Scheer H, Schönrock SM, Runge F, Gutbier B, Lienau J, Hamelmann E, Opitz B, Suttorp N, Mayer K, Behrens GM, Tschernig T, Witzenrath M
Nucleotide oligomerization domain 1 ligation suppressed murine allergen-specific T-cell proliferation and airway hyperresponsiveness.
Am J Respir Cell Mol Biol. 2014 May;50(5):903-11
Müller-Redetzky HC, Will D, Hellwig K, Kummer W, Tschernig T, Pfeil U, Paddenberg R, Menger MD, Kershaw O, Gruber AD, Weissmann N, Hippenstiel S, Suttorp N, Witzenrath M
Mechanical ventilation drives pneumococcal pneumonia into lung injury and sepsis in mice: protection by adrenomedullin.
Crit Care. 2014 Apr 14;18(2):R73.
Müller-Redetzky HC, Suttorp N, Witzenrath M
Dynamics of pulmonary endothelial barrier function in acute inflammation: mechanisms and therapeutic perspectives.
Cell Tissue Res. 2014 Mar;355(3):657-73
Kill A, Tabeling C, Undeutsch R, Kühl AA, Günther J, Radic M, Becker MO, Heidecke H, Worm M, Witzenrath M, Burmester GR, Dragun D, Riemekasten G
Autoantibodies to angiotensin and endothelin receptors in systemic sclerosis induce cellular and systemic events associated with disease pathogenesis.
Arthritis Res Ther. 2014 Jan 28;16(1):R29
Malczyk M, Veith C, Fuchs B, Hofmann K, Storch U, Schermuly RT, Witzenrath M, Ah
Classical Transient Receptor Potential Channel 1 in Hypoxia-induced Pulmonary Hypertension.
Am J Respir Crit Care Med. 2013 Dec 15;188(12):1451-9.
Tabeling C, Scheer H, Schönrock SM, Runge F, Gutbier B, Lienau J, Hamelmann E, Opitz B, Suttorp N, Mayer K, Behrens GM, Tschernig T, Witzenrath M.
NOD1 Ligation Suppressed Murine Allergen-Specific T Cell Proliferation and Airway Hyperresponsiveness.
Am J Respir Cell Mol Biol. 2013 Nov 26.
Schulz R, Murzabekova G, Egemnazarov B, Kraut S, Eisele HJ, Dumitrascu R, Heitmann J, Seimetz M, Witzenrath M, Ghofrani HA, Schermuly RT, Grimminger F, Seeger W, Weissmann N.
Arterial hypertension in a murine model of sleep apnea: role of NADPH oxidase 2.
J Hypertens. 2013 Nov 21.
Bayat B, Tjahjono Y, Sydykov A, Werth S, Hippenstiel S, Weissmann N, Sachs UJ, Santoso S.
Anti-Human Neutrophil Antigen-3a Induced Transfusion-Related Acute Lung Injury in Mice by Direct Disturbance of Lung Endothelial Cells.
Arterioscler Thromb Vasc Biol. 2013 Sep 12. [Epub ahead of print]
Bakr A, Pak O, Taye A, Hamada F, Hemeida R, Janssen W, Gierhardt M, Ghofrani HA, Seeger W, Grimminger F, Schermuly RT, Witzenrath M, Brandes RP, Huang N, Cooke JP, Weissmann N, Sommer N.
Effects of dimethylarginine dimethylaminohydrolase-1 overexpression on the response of the pulmonary vasculature to hypoxia
Am J Respir Cell Mol Biol. 2013 Sep;49(3):491-500
Zahlten J, Steinicke R, Bertrams W, Hocke AC, Scharf S, Schmeck B, Witzenrath M, Hammerschmidt S, Suttorp N, Hippenstiel S.
TLR9- and Src-dependent expression of Krueppel-like factor 4 controls interleukin-10 expression in pneumonia.
Eur Respir J. 2013 Feb;41(2):384-91. Epub 2012 May 31
Hecker M, Sommer N, Voigtmann H, Pak O, Mohr A, Wolf M, Vadász I, Herold S, Weissmann N, Morty R, Seeger W, Mayer K.
Impact of Short- and Medium-Chain Fatty Acids on Mitochondrial Function in Severe Inflammation.
JPEN J Parenter Enteral Nutr. 2013 May 23.
Doehn JM, Fischer K, Reppe K, Gutbier B, Tschernig T, Hocke AC, Fischetti VA, Löffler J, Suttorp N, Hippenstiel S, Witzenrath M.
Delivery of the endolysin Cpl-1 by inhalation rescues mice with fatal pneumococcal pneumonia.
J Antimicrob Chemother. 2013 Sep;68(9):2111-7. doi: 10.1093/jac/dkt131. Epub 2013 Apr 30.
Müller-Redetzky HC, Kummer W, Pfeil U, Hellwig K, Will D, Paddenberg R, Tabeling C, Hippenstiel S, Suttorp N, Witzenrath M.
Intermedin stabilized endothelial barrier function and attenuated ventilator-induced lung injury in mice.
PLoS One. 2012;7(5):e35832. Epub 2012 May 1.
Koppe U, Högner K, Witzenrath M, Bauer S, Hammerschmidt S, Suttorp N, Herold S, Opitz B.
Streptococcus pneumoniae stimulates a STING- and IFN regulatory factor 3-dependent type I IFN production in macrophages, which regulates RANTES production in macrophages, cocultured alveolar epithelial cells, and mouse lungs.
J Immunol. 2012 Jan 15;188(2):811-7
Lippmann J, Müller H, Naujoks J, Tabeling C, Shin S, Witzenrath M, Hellwig K, Kirschning CJ, Taylor GA, Barchet W, Bauer S, Suttorp N, Roy CR, Opitz B
Dissection of a type I interferon pathway in controlling bacterial intracellular infection in mice.
Cell Microbiol. 2011 Nov;13(11):1668-82. doi: 10.1111/j.1462-5822.2011.01646.x. Epub 2011 Aug 24
Müller HC, Hocke AC, Hellwig K, Gutbier B, Peters H, Schönrock SM, Tschernig T, Schmiedl A, Hippenstiel S, N´Guessan PD, Rosseau S, Suttorp N, Witzenrath M.
The Sphingosine-1 Phosphate receptor agonist FTY720 dose dependently affected endothelial integrity in vitro and aggravated ventilator-induced lung injury in mice.
Pulm Pharmacol Ther. 2011 Aug;24(4):377-85. doi: 10.1016/j.pupt.2011.01.017. Epub 2011 Mar 23.
Witzenrath M, Pache F, Lorenz D, Koppe U, Schönrock S, Meixenberger K, Dorhoi A, Ma J, Holmes A, Trendelenburg G, Heimesaat MM, Bereswill S, van der Linden M, Tschopp J, Mitchell TJ, Suttorp N, Opitz B.
The NLRP3 Inflammasome is Differentially Activated by Pneumolysin Variants and Contributes to Host Defense in Pneumococcal Pneumonia.
J Immunol. 2011 Jul 1;187(1):434-40. Epub 2011 Jun 6.
Müller HC, Witzenrath M, Tschernig T, Gutbier B, Hippenstiel S, Santel A, Suttorp N, Rosseau S.
Adrenomedullin attenuates ventilator-induced lung injury in mice.
Thorax. 2010 Dec;65(12):1077-84. Epub 2010 Oct 22
Müller HC, Hellwig K, Rosseau S, Tschernig T, Schmiedl A, Gutbier B, Schmeck B, Hippenstiel S, Peters H, Morawietz L, Suttorp N, Witzenrath M.
Simvastatin attenuates ventilator-induced lung injury in mice.
Crit Care. 2010 14(4):R143. Epub 2010 Jul 30.
Zahlten J, Steinicke R, Opitz B, Eitel J, N´guessan PD, Vinzing M, Witzenrath M, Schmeck B, Hammerschmidt S, Suttorp N, Hippenstiel S.
TLR2- and nucleotide-binding oligomerization domain 2-dependent Krüppel-like factor 2 expression downregulates NF-kappa B-related gene expression.
J Immunol. 2010 Jul 1;185(1):597-604. Epub 2010 Jun 4
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