Publications
C1 Publications
Klabunde B, Wesener A, Bertrams W, Beinborn I, Paczia N, Surmann K, Blankenburg S, Wilhelm J, Serrania J, Knoops K, Elsayed EM, Laakmann K, Jung AL, Kirschbaum A, Hammerschmidt S, Alshaar B, Gisch N, Abu Mraheil M, Becker A, Völker U, Vollmeister E, Benedikter BJ, Schmeck B.
NAD+ metabolism is a key modulator of bacterial respiratory epithelial infections
Nat Commun. 2023 Oct 2;14(1):5818. doi: 10.1038/s41467-023-41372-w. https://pubmed.ncbi.nlm.nih.gov/37783679/
Vidakovic L, Mikhaleva S, Jeckel H, Nisnevich V, Strenger K, Neuhaus K, Raveendran K, Ben-Moshe NB, Aznaourova M, Nosho K, Drescher A, Schmeck B, Schulte LN, Persat A, Avraham R, Drescher K.
Biofilm formation on human immune cells is a multicellular predation strategy of Vibrio cholerae
Cell. 2023 Jun 8;186(12):2690-2704.e20. doi: 10.1016/j.cell.2023.05.008. https://pubmed.ncbi.nlm.nih.gov/37295405/
Jung AL, Han M, Griss K, Bertrams W, Nell C, Greulich T, Klemmer A, Pott H, Heider D, Vogelmeier CF, Hippenstiel S, Suttorp N, Schmeck B.
Novel protein biomarkers for pneumonia and acute exacerbations in COPD: a pilot study.
Front Med (Lausanne). 2023 Jun 5;10:1180746. doi: 10.3389/fmed.2023.1180746. eCollection 2023. https://pubmed.ncbi.nlm.nih.gov/37342494/
Schwerdtner M, Skalik A, Limburg H, Bierwagen J, Jung AL, Dorna J, Kaufmann A, Bauer S, Schmeck B, Böttcher-Friebertshäuser E.
Expression of TMPRSS2 is up-regulated by bacterial flagellin, LPS, and Pam3Cys in human airway cells.
Life Sci Alliance. 2023 May 19;6(8):e202201813. https://pubmed.ncbi.nlm.nih.gov/37208193/
Laakmann K, Eckersberg JM, Hapke M, Wiegand M, Bierwagen J, Beinborn I, Preußer C, Pogge von Strandmann E, Heimerl T, Schmeck B, Jung AL.
Bacterial extracellular vesicles repress the vascular protective factor RNase1 in human lung endothelial cells.
Cell Commun Signal. 2023 May 15;21(1):111. https://pubmed.ncbi.nlm.nih.gov/37189117/
Bierwagen J, Wiegand M, Laakmann K, Danov O, Limburg H, Herbel SM, Heimerl T, Dorna J, Jonigk D, Preußer C, Bertrams W, Braun A, Sewald K, Schulte LN, Bauer S, Pogge von Strandmann E, Böttcher-Friebertshäuser E, Schmeck B, Jung AL.
Bacterial vesicles block viral replication in macrophages via TLR4-TRIF-axis.
Cell Commun Signal. 2023 Mar 28;21(1):65. https://pubmed.ncbi.nlm.nih.gov/36978183/
Herbel SM, Moyon L, Christ M, Elsayed EM, Caffrey BE, Malmsheimer S, Grin I, Hoffmann K, Surmann K, Blankenburg S, Jung AL, Herkt CE, Borsò M, Bozdag B, Imhof A, Becker A, Wagner S, Bange G, Völker U, Bertrams W, Marsico A, Schmeck B.
Screening for eukaryotic motifs in Legionella pneumophila reveals Smh1 as bacterial deacetylase of host histones
Virulence 2022 Dec;13(1):2042-2058.
doi: 10.1080/21505594.2022.2149973. https://pubmed.ncbi.nlm.nih.gov/36411449/
Bertrams W, Hönzke K, Obermayer B, Tönnies M, Bauer TT, Schneider P, Neudecker J, Rückert JC, Stiewe T, Nist A, Eggeling S, Suttorp N, Wolff T, Hippenstiel S, Schmeck B, Hocke AC
Transcriptomic comparison of primary human lung cells with lung tissue samples and the human A549 lung cell line highlights cell type specific responses during infections with influenza A virus
Sci Rep 12, 2022 Nov 29;12(1):20608.
doi 10.1038/s41598-022-24792-4. https://pubmed.ncbi.nlm.nih.gov/36446841/
Lopez Krol A, Nehring HP, Krause FF, Wempe A, Raifer H, Nist A, Stiewe T, Bertrams W, Schmeck B, Luu M, Leister H, Chung HR, Bauer UM, Adhikary T, Visekruna A.
Lactate induces metabolic and epigenetic reprogramming of pro-inflammatory Th17 cells
EMBO Rep. 2022 Oct 10;e54685. doi: 10.15252/embr.202254685. https://pubmed.ncbi.nlm.nih.gov/36215678/
Aznaourova M, Schmerer N, Janga H, Zhang Z, Pauck K, Bushe J, Volkers SM, Wendisch D, Georg P, Ntini E, Aillaud M, Gündisch M, Mack E, Skevaki C, Keller C, Bauer C, Bertrams W, Marsico A, Nist A, Stiewe T, Gruber AD, Ruppert C, Li Y, Garn H, Sander LE, Schmeck B, Schulte LN.
Single-cell RNA sequencing uncovers the nuclear decoy lincRNA PIRAT as a regulator of systemic monocyte immunity during COVID-19
Proc Natl Acad Sci USA. 2022 Sep 6;119(36):e2120680119. doi: 10.1073/pnas.2120680119. Epub 2022 Aug 23. https://pubmed.ncbi.nlm.nih.gov/35998224/
Conrad C, Yildiz D, Cleary SJ, Margraf A, Cook L, Schlomann U, Panaretou B, Bowser JL, Karmouty-Quintana H, Li J, Berg NK, Martin SC, Aljohmani A, Moussavi-Harami SF, Wang KM, Tian JJ, Magnen M, Valet C, Qiu L, Singer JP, Eltzschig HK; CAPSys Study Group, Bertrams W, Herold S, Suttorp N, Schmeck B, Ball ZT, Zarbock A, Looney MR, Bartsch JW.
ADAM8 signaling drives neutrophil migration and ARDS severity
JCI Insight. 2022 Feb 8;7(3):e149870. doi: 10.1172/jci.insight.149870. https://pubmed.ncbi.nlm.nih.gov/35132956/
Jung AL, Schmeck B, Wiegand M, Bedenbender K, Benedikter BJ.
The clinical role of host and bacterial-derived extracellular vesicles in pneumonia
Adv Drug Deliv Rev. 2021 May 19:S0169-409X(21)00185-X. doi: 10.1016/j.addr.2021.05.021. Epub ahead of print. PMID: 34022269. pubmed.ncbi.nlm.nih.gov/34022269/
Bertrams W, Lindhauer NS, Rieke MC, Paas A, Hoffmann K, Greene B, Visekruna A, Vilcinskas A, Seidel K, Schmeck B.
Tribolium castaneum defensin 1 kills Moraxella catarrhalis in an in vitro infection model but does not harm commensal bacteria
Virulence. 2021 Dec;12(1):1003-1010. doi: 10.1080/21505594.2021.1908741. PMID: 33843461; PMCID: PMC8043168. pubmed.ncbi.nlm.nih.gov/33843461/
Bertrams W, Griss K, Han M, Seidel K, Hippenstiel S, Suttorp N, Finkernagel F, Wilhelm J, Vogelmeier CF, Schmeck B.
Transcriptional analysis identifies potential biomarkers and molecular regulators in acute malaria infection
Life Sci. 2021 Apr 1;270:119158. doi: 10.1016/j.lfs.2021.119158. Epub 2021 Feb 2. PMID: 33545200. pubmed.ncbi.nlm.nih.gov/33545200/
Leister H, Luu M, Staudenraus D, Lopez Krol A, Mollenkopf H, Sharma A, Schmerer N, Schulte LN, Bertrams W, Schmeck B, Bosmann M, Steinhoff U, Visekruna A.
Pro- and anti-tumorigenic capacity of immunoproteasomes in shaping the tumor microenvironment
Cancer Immunol Res. 2021 Mar 11. doi: 10.1158/2326-6066.CIR-20-0492. Epub ahead of print. PMID: 33707310. pubmed.ncbi.nlm.nih.gov/33707310/
Linden G, Janga H, Franz M, Nist A, Stiewe T, Schmeck B, Vázquez O, Schulte LN.
Efficient antisense inhibition reveals microRNA-155 to restrain a late-myeloid inflammatory programme in primary human phagocytes
RNA Biol. 2021 Feb 23:1-15. doi: 10.1080/15476286.2021.1885209. Epub ahead of print. PMID: 33622174. pubmed.ncbi.nlm.nih.gov/33622174/
Aznaourova M, Schmerer N, Schmeck B, Schulte LN.
Disease-Causing Mutations and Rearrangements in Long Non-coding RNA Gene Loci
Front Genet. 2020 Nov 30;11:527484. doi: 10.3389/fgene.2020.527484. PMID: 33329688; PMCID: PMC7735109.
Karwelat D, Schmeck B, Ringel M, Benedikter BJ, Hübner K, Beinborn I, Maisner A, Schulte LN, Vollmeister E.
Influenza virus‐mediated suppression of bronchial Chitinase‐3‐like 1 secretion promotes secondary pneumococcal infection
Korfhage N, Mühling M, Ringshandl S, Becker A, Schmeck B, Freisleben B.
Detection and segmentation of morphologically complex eukaryotic cells in fluorescence microscopy images via feature pyramid fusion
Chillappagari S, Garapati V, Mahavadi P, Naehrlich L, Schmeck BT, Schmitz ML, Guenther A.
Defective BACH1/HO-1 regulatory circuits in cystic fibrosis bronchial epithelial cells
Aznaourova M, Janga H, Sefried S, Kaufmann A, Dorna J, Volkers SM, Georg P, Lechner M, Hoppe J, Dökel S, Schmerer N, Gruber AD, Linne U, Bauer S, Sander LE, Schmeck B, Schulte LN
Noncoding RNA MaIL1 is an integral component of the TLR4–TRIF pathway.
Herkt CE, Caffrey BE, Surmann K, Blankenburg S, Gesell Salazar M, Jung AL, Herbel SM, Hoffmann K, Schulte LN, Chen W, Sittka-Stark A, Völker U, Vingron M, Marsico A, Bertrams W, Schmeck B.
A MicroRNA Network Controls Legionella pneumophila Replication in Human Macrophages via LGALS8 and MX1.
Bertrams W, Griss K, Han M, Seidel K, Klemmer A, Sittka-Stark A, Hippenstiel S, Suttorp N, Finkernagel F, Wilhelm J, Greulich T, Vogelmeier C, Vera J, Schmeck B
Transcriptional analysis identifies potential biomarkers and molecular regulators in pneumonia and COPD exacerbation.
Lückel C, Picard F, Raifer H, Campos Carrascosa L, Guralnik A, Zhang Y, Klein M, Bittner S, Steffen F, Moos S, Marini F, Gloury R, Kurschus FC, Chao YY, Bertrams W, Sexl V, Schmeck B, Bonetti L, Grusdat M, Lohoff M, Zielinski CE, Zipp F, Kallies A, Brenner D, Berger M, Bopp T, Tackenberg B, Huber M
IL-17+ CD8+ T cell suppression by dimethyl fumarate associates with clinical response in multiple sclerosis.
Hübner K, Karwelat D, Pietsch E, Beinborn I, Winterberg S, Bedenbender K, Benedikter BJ, Schmeck B, Vollmeister E
NF-κB-mediated inhibition of microRNA-149-5p regulates Chitinase-3-like 1 expression in human airway epithelial cells.
Lindhauer N, Bertrams W, Pöppel A, Herkt C, Wesener A, Hoffmann K, Greene B, van der Linden M, Vilcinskas A, Seidel K, Schmeck B.
Antibacterial activity of a Tribolium castaneum defensin in an in vitro infection model of Streptococcus pneumoniae.
Virulence. 2019 Dec10 (1):902-909
Jung AL, Møller Jørgensen M, Bæk R, Griss K, Han M, auf dem Brinke K, Timmesfeld N, Bertrams W, Greulich T, Koczulla AR, Hippenstiel S, Suttorp N, Schmeck B.
Surface proteome of plasma extracellular vesicles as biomarkers for pneumonia and acute exacerbation of COPD.
J Infect Dis. 2019 Oct 16. pii: jiz460
Limburg H, Harbig A, Bestle D, Stein DA, Moulton HM, Jaeger J, Janga H, Hardes K, Koepke J, Schulte L, Koczulla AR, Schmeck B, Klenk HD, Böttcher-Friebertshäuser E.
TMPRSS2 is the major activating protease of influenza A virus in primary human airway cells and influenza B virus in human type II pneumocytes.
J Virol. 2019 Oct 15;93(21). pii: e00649-19
Dabrowski AN, Shrivastav A, Conrad C, Komma K, Weigel M, Dietert K, Gruber A, Bertrams W, Wilhelm J, Schmeck B, Reppe K, N'Guessan PD, Aly S, Suttorp N, Hain T, Zahlten J.
Peptidoglycan recognition protein 4 limits bacterial clearance and inflammation in lungs by control of the gut microbiota.
Front Immunol. 2019 Sep 20;10:2106
Nandakumar R, Tschismarov R, Meissner F, Prabakaran T, Krissanaprasit A, Farahani E, Zhang BC, Assil S, Martin A, Bertrams W, Holm CK, Ablasser A, Klause T, Thomsen MK, Schmeck B, Howard KA, Henry T, Gothelf KV, Decker T, Paludan SR
Intracellular bacteria engage a STING-TBK1-MVB12b pathway to enable paracrine cGAS-STING signalling.
Nat Microbiol. 2019 Apr;4(4):701-713, Epub 2019 Feb 25
Visekruna A, Hartmann S, Sillke YR, Glauben R, Fischer F, Raifer H, Mollenkopf H, Bertrams W, Schmeck B, Klein M, Pagenstecher A, Lohoff M, Jacob R, Pabst O, Bland PW, Luu M, Romero R, Siegmund B, Rajalingam K, Steinhoff U
Intestinal development and homeostasis require activation and apoptosis of diet-reactive T cells.
J Clin Invest. 2019 Apr 2;130. pii: 98929. eCollection 2019 Apr 2
Scheller N, Herold S, Kellner R, Bertrams W, Jung AL, Janga H, Greulich T, Schulte LN, Vogelmeier CF, Lohmeyer J, Schmeck B
Proviral MicroRNAs Detected in Extracellular Vesicles From Bronchoalveolar Lavage Fluid of Patients With Influenza Virus-Induced Acute Respiratory Distress Syndrome.
J Infect Dis. 2019 Jan 29;219(4):540-543
Schulte LN, Bertrams W, Stielow C, Schmeck B
ncRNAs in Inflammatory and Infectious Diseases.
Methods Mol Biol. 2019;1912:3-32
Schulte LN, Heinrich B, Janga H, Schmeck BT, Vázquez O
A Far-Red Fluorescent DNA Binder for Interaction Studies of Live Multidrug-Resistant Pathogens and Host.
Cells. Angew Chem Int Ed Engl. 2018 Sep 3;57(36):11564-11568
Gutbier B, Schönrock SM, Ehrler C, Haberberger R, Dietert K, Gruber AD, Kummer W, Michalik L, Kübler WM, Hocke AC, Szymanski K, Letsiou E, Lüth A, Schumacher F, Kleuser B, Mitchell TJ, Bertrams W, Schmeck B, Treue D, Klauschen F, Bauer TT, Tönnies M,
Sphingosine kinase 1 regulates inflammation and contributes to acute lung injury in pneumococcal pneumonia via the S1P receptor 2.
Crit Care Med. 2018 Jan 2.
Schulz C, Lai X, Bertrams W, Jung AL, Sittka-Stark A, Herkt CE, Janga H, Zscheppang K, Stielow C, Schulte L, Hippenstiel S, Vera J, Schmeck B
THP-1-derived macrophages render lung epithelial cells hypo-responsive to Legionella pneumophila - a systems biology study.
Sci Rep. 2017 Sep 20;7(1):11988
Jung AL, Herkt CE, Schulz C, Bolte K, Seidel K, Scheller N, Sittka-Stark A, Bertrams W, Schmeck B
Legionella pneumophila infection activates bystander cells differentially by bacterial and host cell vesicles.
Sci Rep. 2017 Jul 24;7(1):6301
Jentho E, Bodden M, Schulz C, Jung AL, Seidel K, Schmeck B, Bertrams W
microRNA-125a-3p is regulated by MyD88 in Legionella pneumophila infection and targets NTAN1.
PLoS One. 2017 Apr 26;12(4):e0176204
Wentker P, Eberhardt M, Dreyer FS, Bertrams W, Cantone M, Griss K, Schmeck B, Vera J
An Interactive Macrophage Signal Transduction Map Facilitates Comparative Analyses of High-Throughput Data.
J Immunol. 2017 Mar 1;198(5):2191
Jung AL, Hoffmann K, Herkt CE, Schulz C, Bertrams W, Schmeck B
Legionella pneumophila Outer Membrane Vesicles: Isolation and Analysis of Their Pro-inflammatory Potential on Macrophages.
J Vis Exp. 2017 Feb 22;(120)
https://www.jove.com/video/55146/legionella-pneumophila-outer-membrane-vesicles-isolation-analysis
Du Bois I, Marsico A, Bertrams W, Schweiger MR, Caffrey BE, Sittka-Stark A, Eberhardt M, Vera J, Vingron M, Schmeck BT
Genome-wide Chromatin Profiling of Legionella pneumophila-Infected Human Macrophages Reveals Activation of the Probacterial Host Factor TNFAIP2.
J Infect Dis. 2016 Aug 1;214(3):454-63
Jung AL, Stoiber C, Herkt CE, Schulz C, Bertrams W, Schmeck B
Legionella pneumophila-derived outer membrane vesicles promote bacterial replication in macrophages.
PLoS Pathog. 2016 Apr 22;12(4)
Griss K, Bertrams W, Sittka-Stark A, Seidel K, Stielow C, Hippenstiel S, Suttorp N, Eberhardt M, Wilhelm J, Vera J, Schmeck B
MicroRNAs constitute a negative feedback loop in Streptococcus pneumoniae induced macrophage activation.
J Infect Dis. 2016 Mar 16
Conrad T, Marsico A, Gehre M, Orom UA
Microprocessor activity controls differential miRNA biogenesis In Vivo.
Cell Rep. 2014 Oct 23;9(2):542-54
Marsico A, Huska MR, Lasserre J, Hu H, Vucicevic D, Musahl A, Orom UA, Vingron M.
PROmiRNA: a new miRNA promoter recognition method uncovers the complex regulation of intronic miRNAs.
Genome Biol. 2013 Aug 16;14(8)
Sittka A, Schmeck B.
MicroRNAs in the lung.
Adv Exp Med Biol. 2013;774:121-34. doi: 10.1007/978-94-007-5590-1_7. Review.
Zahlten J, Steinicke R, Bertrams W, Hocke AC, Scharf S, Schmeck B, Witzenrath M, Hammerschmidt S, Suttorp N, Hippenstiel S.
TLR9- and Src-dependent expression of Krueppel-like factor 4 controls interleukin-10 expression in pneumonia.
Eur Respir J. 2013 Feb;41(2):384-91. Epub 2012 May 31
Sittka A, Vera J, Lai X, Schmeck BT.
Asthma phenotyping, therapy, and prevention: what can we learn from systems biology?
Pediatr Res. 2013 Apr;73(4 Pt 2):543-52. doi: 10.1038/pr.2013.8. Epub 2013 Jan 11. Review.
Eitel J, Meixenberger K, van Laak C, Orlovski C, Hocke A, Schmeck B, Hippenstiel S, N’Guessan PD, Suttorp N, Opitz B
Rac1 regulates the NLRP3 inflammasome which mediates IL-1beta production in Chlamydophila pneumoniae infected human mononuclear cells.
PLoS One. 2012;7(1):e30379. doi: 10.1371/journal.pone.0030379. Epub 2012 Jan 20.
Lorenz J, Zahlten J, Pollok I, Lippmann J, Scharf S, N´Guessan PD, Opitz B, Flieger A, Suttorp N, Hippenstiel S, Schmeck B.
Legionella pneumophila-induced I?B?-dependent expression of interleukin-6 in lung epithelium.
Eur Respir J. 2011 Mar;37(3):648-57. Epub 2010 Jul 22.
Scharf S, Vardarova K, Lang F, Schmeck B, Opitz B, Flieger A, Heuner K, Hippenstiel S, Suttorp N, N´Guessan PD.
Legionella pneumophila induces human beta defensin-3 in pulmonary cells.
Respir Res. 2010 Jul 8;11:93.
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