Transregio SFB-TR 84 “Innate Immunity of the Lung: Mechanisms of Pathogen Attack and Host Defence in Pneumonia“

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Publications

C1 Publications

Lindhauer N, Bertrams W, Pöppel A, Herkt C, Wesener A, Hoffmann K, Greene B, van der Linden M, Vilcinskas A, Seidel K, Schmeck B.

Antibacterial activity of a Tribolium castaneum defensin in an in vitro infection model of Streptococcus pneumoniae.

Virulence. 2019 Dec10 (1):902-909

https://www.ncbi.nlm.nih.gov/pubmed/31657264

Jung AL, Møller Jørgensen M, Bæk R, Griss K, Han M, auf dem Brinke K, Timmesfeld N, Bertrams W, Greulich T, Koczulla AR, Hippenstiel S, Suttorp N, Schmeck B.

Surface proteome of plasma extracellular vesicles as biomarkers for pneumonia and acute exacerbation of COPD.

J Infect Dis. 2019 Oct 16. pii: jiz460

https://www.ncbi.nlm.nih.gov/pubmed/31617573

Limburg H, Harbig A, Bestle D, Stein DA, Moulton HM, Jaeger J, Janga H, Hardes K, Koepke J, Schulte L, Koczulla AR, Schmeck B, Klenk HD, Böttcher-Friebertshäuser E.

TMPRSS2 is the major activating protease of influenza A virus in primary human airway cells and influenza B virus in human type II pneumocytes.

J Virol. 2019 Oct 15;93(21). pii: e00649-19

https://www.ncbi.nlm.nih.gov/pubmed/31391268

Dabrowski AN, Shrivastav A, Conrad C, Komma K, Weigel M, Dietert K, Gruber A, Bertrams W, Wilhelm J, Schmeck B, Reppe K, N'Guessan PD, Aly S, Suttorp N, Hain T, Zahlten J.

Peptidoglycan recognition protein 4 limits bacterial clearance and inflammation in lungs by control of the gut microbiota.

Front Immunol. 2019 Sep 20;10:2106

https://www.ncbi.nlm.nih.gov/pubmed/31616404

Nandakumar R, Tschismarov R, Meissner F, Prabakaran T, Krissanaprasit A, Farahani E, Zhang BC, Assil S, Martin A, Bertrams W, Holm CK, Ablasser A, Klause T, Thomsen MK, Schmeck B, Howard KA, Henry T, Gothelf KV, Decker T, Paludan SR

Intracellular bacteria engage a STING-TBK1-MVB12b pathway to enable paracrine cGAS-STING signalling.

Nat Microbiol. 2019 Apr;4(4):701-713, Epub 2019 Feb 25

https://www.ncbi.nlm.nih.gov/pubmed/30804548

Visekruna A, Hartmann S, Sillke YR, Glauben R, Fischer F, Raifer H, Mollenkopf H, Bertrams W, Schmeck B, Klein M, Pagenstecher A, Lohoff M, Jacob R, Pabst O, Bland PW, Luu M, Romero R, Siegmund B, Rajalingam K, Steinhoff U

Intestinal development and homeostasis require activation and apoptosis of diet-reactive T cells.

J Clin Invest. 2019 Apr 2;130. pii: 98929. eCollection 2019 Apr 2

https://www.ncbi.nlm.nih.gov/pubmed/30939122

Scheller N, Herold S, Kellner R, Bertrams W, Jung AL, Janga H, Greulich T, Schulte LN, Vogelmeier CF, Lohmeyer J, Schmeck B

Proviral MicroRNAs Detected in Extracellular Vesicles From Bronchoalveolar Lavage Fluid of Patients With Influenza Virus-Induced Acute Respiratory Distress Syndrome.

J Infect Dis. 2019 Jan 29;219(4):540-543

https://www.ncbi.nlm.nih.gov/pubmed/30239899

Schulte LN, Bertrams W, Stielow C, Schmeck B

ncRNAs in Inflammatory and Infectious Diseases.

Methods Mol Biol. 2019;1912:3-32

https://www.ncbi.nlm.nih.gov/pubmed/30635888

Schulte LN, Heinrich B, Janga H, Schmeck BT, Vázquez O

A Far-Red Fluorescent DNA Binder for Interaction Studies of Live Multidrug-Resistant Pathogens and Host.

Cells. Angew Chem Int Ed Engl. 2018 Sep 3;57(36):11564-11568

https://www.ncbi.nlm.nih.gov/pubmed/29972713

Gutbier B, Schönrock SM, Ehrler C, Haberberger R, Dietert K, Gruber AD, Kummer W, Michalik L, Kübler WM, Hocke AC, Szymanski K, Letsiou E, Lüth A, Schumacher F, Kleuser B, Mitchell TJ, Bertrams W, Schmeck B, Treue D, Klauschen F, Bauer TT, Tönnies M,

Sphingosine kinase 1 regulates inflammation and contributes to acute lung injury in pneumococcal pneumonia via the S1P receptor 2.

Crit Care Med. 2018 Jan 2.

https://www.ncbi.nlm.nih.gov/pubmed/29298188

Schulz C, Lai X, Bertrams W, Jung AL, Sittka-Stark A, Herkt CE, Janga H, Zscheppang K, Stielow C, Schulte L, Hippenstiel S, Vera J, Schmeck B

THP-1-derived macrophages render lung epithelial cells hypo-responsive to Legionella pneumophila - a systems biology study.

Sci Rep. 2017 Sep 20;7(1):11988

https://www.ncbi.nlm.nih.gov/pubmed/28931863

Jung AL, Herkt CE, Schulz C, Bolte K, Seidel K, Scheller N, Sittka-Stark A, Bertrams W, Schmeck B

Legionella pneumophila infection activates bystander cells differentially by bacterial and host cell vesicles.

Sci Rep. 2017 Jul 24;7(1):6301

https://www.ncbi.nlm.nih.gov/pubmed/28740179

Jentho E, Bodden M, Schulz C, Jung AL, Seidel K, Schmeck B, Bertrams W

microRNA-125a-3p is regulated by MyD88 in Legionella pneumophila infection and targets NTAN1.

PLoS One. 2017 Apr 26;12(4):e0176204

https://www.ncbi.nlm.nih.gov/pubmed/28445535

Wentker P, Eberhardt M, Dreyer FS, Bertrams W, Cantone M, Griss K, Schmeck B, Vera J

An Interactive Macrophage Signal Transduction Map Facilitates Comparative Analyses of High-Throughput Data.

J Immunol. 2017 Mar 1;198(5):2191

https://www.ncbi.nlm.nih.gov/pubmed/28137890

Jung AL, Hoffmann K, Herkt CE, Schulz C, Bertrams W, Schmeck B

Legionella pneumophila Outer Membrane Vesicles: Isolation and Analysis of Their Pro-inflammatory Potential on Macrophages.

J Vis Exp. 2017 Feb 22;(120)

https://www.jove.com/video/55146/legionella-pneumophila-outer-membrane-vesicles-isolation-analysis

Du Bois I, Marsico A, Bertrams W, Schweiger MR, Caffrey BE, Sittka-Stark A, Eberhardt M, Vera J, Vingron M, Schmeck BT

Genome-wide Chromatin Profiling of Legionella pneumophila-Infected Human Macrophages Reveals Activation of the Probacterial Host Factor TNFAIP2.

J Infect Dis. 2016 Aug 1;214(3):454-63

https://www.ncbi.nlm.nih.gov/pubmed/27130431

Budach S, Heinig M, Marsico A

Principles of microRNA Regulation Revealed Through Modeling microRNA Expression Quantitative Trait Loci.

Genetics. 2016 Aug;203(4):1629-40

https://www.ncbi.nlm.nih.gov/pubmed/27260304

Jung AL, Stoiber C, Herkt CE, Schulz C, Bertrams W, Schmeck B

Legionella pneumophila-derived outer membrane vesicles promote bacterial replication in macrophages.

PLoS Pathog. 2016 Apr 22;12(4)

http://www.ncbi.nlm.nih.gov/pubmed/27105429

Griss K, Bertrams W, Sittka-Stark A, Seidel K, Stielow C, Hippenstiel S, Suttorp N, Eberhardt M, Wilhelm J, Vera J, Schmeck B

MicroRNAs constitute a negative feedback loop in Streptococcus pneumoniae induced macrophage activation.

J Infect Dis. 2016 Mar 16

http://www.ncbi.nlm.nih.gov/pubmed/26984146

Conrad T, Marsico A, Gehre M, Orom UA

Microprocessor activity controls differential miRNA biogenesis In Vivo.

Cell Rep. 2014 Oct 23;9(2):542-54

 

https://www.ncbi.nlm.nih.gov/pubmed/25310978

Marsico A, Huska MR, Lasserre J, Hu H, Vucicevic D, Musahl A, Orom UA, Vingron M.

PROmiRNA: a new miRNA promoter recognition method uncovers the complex regulation of intronic miRNAs.

Genome Biol. 2013 Aug 16;14(8)

http://genomebiology.com/2013/14/8/R84

von Deetzen MC, Schmeck B, Gruber AD, Klopfleisch R.

Molecular quantification of canine specific microRNA species.

Res Vet Sci. 2013 Oct;95(2):562-8. Epub 2013 Jul 22.

http://www.ncbi.nlm.nih.gov/pubmed/23886399

Sittka A, Schmeck B.

MicroRNAs in the lung.

Adv Exp Med Biol. 2013;774:121-34. doi: 10.1007/978-94-007-5590-1_7. Review.

http://www.ncbi.nlm.nih.gov/pubmed/23377971

Zahlten J, Steinicke R, Bertrams W, Hocke AC, Scharf S, Schmeck B, Witzenrath M, Hammerschmidt S, Suttorp N, Hippenstiel S.

TLR9- and Src-dependent expression of Krueppel-like factor 4 controls interleukin-10 expression in pneumonia.

Eur Respir J. 2013 Feb;41(2):384-91. Epub 2012 May 31

http://www.ncbi.nlm.nih.gov/pubmed/22653776

Sittka A, Vera J, Lai X, Schmeck BT.

Asthma phenotyping, therapy, and prevention: what can we learn from systems biology?

Pediatr Res. 2013 Apr;73(4 Pt 2):543-52. doi: 10.1038/pr.2013.8. Epub 2013 Jan 11. Review.

http://www.ncbi.nlm.nih.gov/pubmed/?term=23314293

Fuellen G, Dengjel J, Hoeflich A, Hoeijemakers J, Kestler HA, Kowald A, Priebe S, Rebholz-Schuhmann D, Schmeck B, Schmitz U, Stolzing A, Sühnel J, Wuttke D, Vera J.

Systems biology and bioinformatics in aging research: a workshop report.

Rejuvenation Res. 2012 Dec;15(6):631-41. doi: 10.1089/rej.2012.1360. Epub 2012 Nov 19.

http://www.ncbi.nlm.nih.gov/pubmed/?term=22950424

Eitel J, Meixenberger K, van Laak C, Orlovski C, Hocke A, Schmeck B, Hippenstiel S, N’Guessan PD, Suttorp N, Opitz B

Rac1 regulates the NLRP3 inflammasome which mediates IL-1beta production in Chlamydophila pneumoniae infected human mononuclear cells.

PLoS One. 2012;7(1):e30379. doi: 10.1371/journal.pone.0030379. Epub 2012 Jan 20.

http://www.ncbi.nlm.nih.gov/pubmed/22276187

Müller HC, Hellwig K, Rosseau S, Tschernig T, Schmiedl A, Gutbier B, Schmeck B, Hippenstiel S, Peters H, Morawietz L, Suttorp N, Witzenrath M.

Simvastatin attenuates ventilator-induced lung injury in mice.

Crit Care. 2010 14(4):R143. Epub 2010 Jul 30.

http://www.ncbi.nlm.nih.gov/pubmed/20673352

Lorenz J, Zahlten J, Pollok I, Lippmann J, Scharf S, N´Guessan PD, Opitz B, Flieger A, Suttorp N, Hippenstiel S, Schmeck B.

Legionella pneumophila-induced I?B?-dependent expression of interleukin-6 in lung epithelium.

Eur Respir J. 2011 Mar;37(3):648-57. Epub 2010 Jul 22.

http://www.ncbi.nlm.nih.gov/pubmed/20650996

Scharf S, Vardarova K, Lang F, Schmeck B, Opitz B, Flieger A, Heuner K, Hippenstiel S, Suttorp N, N´Guessan PD.

Legionella pneumophila induces human beta defensin-3 in pulmonary cells.

Respir Res. 2010 Jul 8;11:93.

http://www.ncbi.nlm.nih.gov/pubmed/20615218

Zahlten J, Steinicke R, Opitz B, Eitel J, N´guessan PD, Vinzing M, Witzenrath M, Schmeck B, Hammerschmidt S, Suttorp N, Hippenstiel S.

TLR2- and nucleotide-binding oligomerization domain 2-dependent Krüppel-like factor 2 expression downregulates NF-kappa B-related gene expression.

J Immunol. 2010 Jul 1;185(1):597-604. Epub 2010 Jun 4

http://www.ncbi.nlm.nih.gov/pubmed/20525885