Transregio SFB-TR 84 “Innate Immunity of the Lung: Mechanisms of Pathogen Attack and Host Defence in Pneumonia“

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Publications

Bertrams W, Griss K, Han M, Seidel K, Hippenstiel S, Suttorp N, Finkernagel F, Wilhelm J, Vogelmeier CF, Schmeck B.

Transcriptional analysis identifies potential biomarkers and molecular regulators in acute malaria infection

Life Sci. 2021 Apr 1;270:119158. doi: 10.1016/j.lfs.2021.119158. Epub 2021 Feb 2. PMID: 33545200. pubmed.ncbi.nlm.nih.gov/33545200/

Brown R, Small DM, Doherty DF, Holsinger L, Booth R, Williams R, Ingram RJ, Elborn JS, Mall MA, Taggart CC, Weldon S.

Therapeutic Inhibition of Cathepsin S Reduces Inflammation and Mucus Plugging in Adult βENaC-Tg Mice.

Mediators Inflamm. 2021 Mar 19;2021:6682657. doi: 10.1155/2021/6682657. PMID: 33828414; PMCID: PMC8004367.

pubmed.ncbi.nlm.nih.gov/33828414/

Vazquez-Armendariz AI, Herold S.

From Clones to Buds and Branches. The Use of Lung Organoids to Mod Branching Morphogenesis Ex Vivo

Front Cell Dev Biol. 2021 Mar 4;9:631579. doi: 10.3389/fcell.2021.631579. PMID: 33748115; PMCID: PMC7969706. pubmed.ncbi.nlm.nih.gov/33748115/

Ochs M, Timm S, Elezkurtaj S, Horst D, Meinhardt J, Heppner FL, Weber-Carstens S, Hocke AC, Witzenrath M.

Collapse induration of alveoli is an ultrastructural finding in a COVID-19 patient

Eur Respir J. 2021 Jan 14:2004165. doi: 10.1183/13993003.04165-2020. Epub ahead of print. PMID: 33446606; PMCID: PMC7815985. pubmed.ncbi.nlm.nih.gov/33446606/

Linzner N, Loi VV, Fritsch VN, Antelmann H.

Thiol-based redox switches in the major pathogen Staphylococcus aureus.

Biol Chemistry 2020 Dec 1.

Fritsch VN, Loi VV, Busche T, Tung QN, Lill R, Horvatek P, Wolz C, Kalinowski J, Antelmann H.

Fritsch VN, Loi VV, Busche T, Tung QN, Lill R, Horvatek P, Wolz C, Kalinowski J, Antelmann H.

Free Radic Biol Med. 2020 Dec;161:351-364. doi: 10.1016/j.freeradbiomed.2020.10.322.

Michalick L, Weidenfeld S, Grimmer B, Fatykhova D, Solymosi PD, Behrens F, Dohmen M, Brack MC, Schulz S, Thomasch E, Simmons S, Müller-Redetzky H, Suttorp N, Kurth F, Neudecker J, Toennies M, Bauer TT, Eggeling S, Corman VM, Hocke AC, Witzenrath M, Hippenstiel S, Kuebler WM.

Plasma mediators in patients with severe COVID-19 cause lung endothelial barrier failure

Eur Respir J. 2020 Nov 5;2002384. doi: 10.1183/13993003.02384-2020. Online ahead of print.

Vázquez-Armendariz AI, Heiner M, El Agha E, Salwig I, Hoek A, Rupp MC, Shalashova I, Shrestha A, Carraro G, Mengel JP, Günther A, Morty RE, Vadasz I, Schwemmle M, Kummer W, Hain T, Goesmann A, Bellusci S, Seeger W, Braun T, Herold S.

Multilineage murine stem cells generate complex organoids to model distal lung development and disease

EMBO J. 2020 Nov 2;39(21):e103476. doi: 10.15252/embj.2019103476.

Nerlich A, von Wunsch Teruel I, Mieth M, Hönzke K, Rückert JC, Mitchell TJ, Suttorp N, Hippenstiel S, Hocke AC.

Reversion of pneumolysin induced executioner caspase activation redirects cells to survival

J Infect Dis. 2020 Oct 12;jiaa639. doi: 10.1093/infdis/jiaa639.

Linzner N, Fritsch VN, Busche T, Tung QN, Loi VV, Bernhardt J, Kalinowski J, Antelmann H.

The plant-derived naphthoquinone lapachol causes an oxidative stress response in Staphylococcus aureus

Free Radic Biol Med. 2020 Oct;158:126-136. doi: 10.1016/j.freeradbiomed.2020.07.025.

Myti D, Gunjak M, Casado F, Khaghani Raziabad S, Nardiello C, Vadasz I, Herold S, Pryhuber G, Seeger W, Morty RE.

Elevated FiO 2 increases SARS-CoV-2 co-receptor expression in respiratory tract epithelium

Am J Physiol Lung Cell Mol Physiol. 2020 Oct 1;319(4):L670-L674. doi: 10.1152/ajplung.00345.2020.

Kreye J, Reincke SM, Kornau HC, Sanchez-Sendin E, Corman VM, Liu H, Yuan M, Wu NC, Zhu X, Lee CD, Trimpert J, Hoeltje M, Dietert K, Stoeffler L, von Wardenburg N, van Hoof S, Homeyer MA, Hoffmann J, Abdelgawad A, Gruber AD, Bertzbach LD, Vladimirova D, Li LY, Barthel PC, Skriner K, Hocke AC, Hippenstiel S, Witzenrath M, Suttorp N, Kurth F, Franke C, Endres M, Schmitz D, Jeworowski LM, Richter A, Schmidt ML, Schwarz T, Mueller MA, Drosten C, Wendisch D, Sander LE, Osterrieder N, Wilson IA, Pruess H.

A therapeutic non-self-reactive SARS-CoV-2 antibody protects from lung pathology in a COVID-19 hamster model.

CELL 11649

Hahn L, Helmrich N, Herebian D, Mayatepek E, Drebber U, Domann E, Olejniczak S, Weigel M, Hain T, Rath T, Wirtz S, Mollenkopf HJ, Schmidt N, Ewers C, Churin Y, Windhorst A, Weiskirchen R, Steinhoff U, Roeb E, Roderfeld M.

IL-13 as target to reduce cholestasis and dysbiosis in Abcb4 knockout mice.

Cells, 9:E1949 2020.

Vega G, Guequén A, Philp AR, Gianotti A, Arzola L, Villalón M, Zegarra-Moran O, Galietta LJ, Mall MA, Flores CA.

Lack of Kcnn4 improves mucociliary clearance in muco-obstructive lung disease.

JCI Insight. 2020 Aug 20;5(16):e140076. doi: 10.1172/jci.insight.140076.

Schulte-Schrepping J, Reusch N, Paclik D, Baßler K, Schlickeiser S, Zhang B, Krämer B, Krammer T, Brumhard S, Bonaguro L, De Domenico E, Wendisch D, Grasshoff M, Kapellos TS, Beckstette M, Pecht T, Saglam A, Dietrich O, Mei HE, Schulz AR, Conrad C, Kunkel D, Vafadarnejad E, Xu C-J, Horne A, Herbert M, Drews A, Thibeault C, Pfeiffer M, Hippenstiel S, Hocke A, Müller-Redetzky H, Heim K-M, Machleidt F, Uhrig A, Bosquillon de Jarcy L, Jürgens L, Stegemann M, Glösenkamp CR, Volk H-D, Goffinet C, Landthaler M, Wyler E, Georg P, Schneider M, Dang-Heine C, Neuwinger N, Kappert K, Tauber R, Corman V, Raabe J, Kaiser KM, To Vinh M, Rieke G, Meisel C, Ulas T, Becker M, Geffers R, Witzenrath M, Drosten C, Suttorp N, von Kalle C, Kurth F, Händler K, Schultze JL, Aschenbrenner AC, Li Y, Nattermann J, Sawitzki B, Saliba A-E, Sander LE

Severe COVID-19 is marked by a dysregulated myeloid cell compartment

Cell. 2020 Aug 5;S0092-8674(20)30992-2

Braun J , Loyal L, Frentsch M, Wendisch D , Georg P , Kurth F , Hippenstiel S, Dingeldey M, Kruse B, Fauchere F, Baysal E, Mangold M, Henze L, Lauster R, Mall MA, Beyer K, Röhmel J, Voigt S, Schmitz J, Miltenyi S, Demuth I, Müller MA, Hocke A, Witzenrath M, Suttorp N, Kern F, Reimer U, Wenschuh H, Drosten C, Corman VM, Giesecke-Thiel C, Sander LE, Thiel A

SARS-CoV-2-reactive T cells in healthy donors and patients with COVID-19

Nature. 2020 Jul 29. doi: 10.1038/s41586-020-2598-9

Messner CB, Demichev V, Wendisch D, Michalick L, White M, Freiwald A, Textoris-Taube K, Vernardis SI, Egger AS, Kreidl M, Ludwig D, Kilian C, Agostini F, Zelezniak A, Thibeault C, Pfeiffer M, Hippenstiel S, Hocke A, von Kalle C, Campbell A, Hayward C, Porteous DJ, Marioni RE, Langenberg C, Lilley KS, Kuebler WM, Mülleder M, Drosten C, Suttorp N, Witzenrath M, Kurth F, Sander LE, Ralser M

Ultra-High-Throughput Clinical Proteomics Reveals Classifiers of COVID-19 Infection

Cell Syst. 2020 Jul 22;11(1):11-24.e4.

Sauerhering L, Kupke A, Meier L, Dietzel E, Hoppe J, Gruber AD, Gattenloehner S, Witte B, Fink L, Hofmann N, Zimmermann T, Goesmann A, Nist A, Stiewe T, Becker S, Herold S, Peteranderl C.

Cyclophilin Inhibitors Restrict Middle East Respiratory Syndrome Coronavirus Via Interferon λ In Vitro And In Mice

Eur Respir J. 2020 Jul 2; 1901826.

Lorenz Chua R, Lukassen Soeren, Trump S, Hennig BP, Wendisch D, Pott F, Debnath O, Thürmann L, Kurth F, Völker MT, Kazmierski Julia, Timmermann B, Twardziok S, Schneider S, Machleidt F, Müller-Redetzky H , Maier M, Krannich A, Schmidt S, Balzer F, Liebig J, Loske J, Suttorp N, Eils J, Ishaque N, Liebert UG, von Kalle C, Hocke A, Witzenrath M, Goffinet C, Drosten C, Laudi S, Lehmann I, Conrad C, Sander LE, Eils R

COVID-19 severity correlates with airway epithelium-immune cell interactions identified by single-cell analysis

Nat Biotechnol. 2020 Aug;38(8):970-979

Kurth F, Roennefarth M, Thibeault C, Corman VM, Müller-Redetzky H, Mittermaier M, Ruwwe-Glösenkamp C, Heim KM, Krannich A, Zvorc S, Schmidt S, Kretzler L, Dang-Heine C, Rose M, Hummel M, Hocke A, Hübner RH, Opitz B, Mall MA, Röhmel J, Landmesser U, Pieske B, Knauss S, Endres M, Spranger J, Mockenhaupt FP, Tacke F, Treskatsch S, Angermair S, Siegmund B, Spies C, Weber-Carstens S, Eckardt KU, Schürmann D, Uhrig A, Stegemann MS, Zoller T, Drosten C, Suttorp N, Witzenrath M, Hippenstiel S, von Kalle C, Sander LE.

Studying the pathophysiology of coronavirus disease 2019: a protocol for the Berlin prospective COVID-19 patient cohort (Pa-COVID-19).

Infection. 2020 Aug;48(4):619-626.

Duerr J, Leitz DHW, Szczygiel M, Dvornikov D, Fraumann SG Kreutz C, Zadora PK, Seyhan Agircan A Konietzke P, Engelmann TA, Hegermann J, Mulugeta S, Kawabe H, Knudsen L, Ochs M, Rotin D, Muley T, Kreuter M, Herth FJF, Wielpütz MO, Beers MF, Klingmüller U, Mall MA

Conditional deletion of Nedd4-2 in lung epithelial cells causes progressive pulmonary fibrosis in adult mice.

Nat Commun. 2020 Apr 24;11(1):2012

Van Loi V, Antelmann H.

Method for measurement of bacillithiol redox potential changes using the Brx-roGFP2 redox biosensor in Staphylococcus aureus

MethodsX. 2020 Apr 24;7:100900. doi: 10.1016/j.mex.2020.100900.

Perniss A, Latz A, Boseva I, Papadakis T, Dames C, Meisel C, Meisel A, Scholze P, Kummer W, Krasteva-Christ G

Acute nicotine administration stimulates ciliary activity via α3β4 nAChR in the mouse trachea.

Int Immunopharmacol. 2020 Apr 15;84:106496

Lauster D, Klenk S, Ludwig K, Nojoumi S, Behren S, Adam L, Stadtmüller M, Saenger S, Zimmler S, Hönzke K, Yao L, Hoffmann U, Bardua M, Hamann A, Witzenrath M, Sander LE, Wolff T, Hocke AC, Hippenstiel S, De Carlo S, Neudecker J, Osterrieder K, Budisa N, Netz RR, Böttcher C, Liese S, Herrmann A, Hackenberger CPR

Phage capsid nanoparticles with defined ligand arrangement block influenza virus entry

Nat Nanotechnol. 2020 May;15(5):373-379

Brown R, Paulsen M, Schmidt S, Schatterny J, Frank A, Hirtz S, Delaney R, Doherty D, Hagner M, Taggart C, Weldon S, Mall MA

Lack of IL-1 receptor signaling reduces spontaneous airway eosinophilia in juvenile mice with muco-obstructive lung disease.

Am J Respir Cell Mol Biol. 2020 Mar;62(3):300-309.

Hagner M, Frey DL, Guerra M, Dittrich AS, Halls VS, Wege S, Herth FJF, Schultz C, Mall MA

New method for rapid and dynamic quantification of elastase activity on sputum neutrophils from patients with cystic fibrosis using flow cytometry.

Eur Respir J. 2020 Mar 5. pii: 1902355

Rohilla S, Krämer B, Koberling F, Gregor I, Hocke AC.

Multi-target immunofluorescence by separation of antibody cross-labelling via spectral-FLIM-FRET

Sci Rep. 2020 Mar 2;10(1):3820

Herold S and Sander LE.

Toward a universal flu vaccine.

Science 367: 852-853, 2020.

McKelvey MC, Weldon S, McAuley DF, Mall MA, Taggart CC

Targeting proteases in cystic fibrosis lung disease: Paradigms, progress, and potential.

Am J Respir Crit Care Med. 2020 Jan 15;201(2):141-147.

Bell SC, Mall MA, Gutierrez H, Macek M, Madge S, Davies JC, Burgel PR, Tullis E, Castanos C, Castellani C, Byrnes CA, Cathcart F, Chotirmall SH, Cosgriff R, Eichler I, Fajac I, Goss CH, Drevinek P, Farrell PM, Gravelle AM, Havermans T, Mayer-Hamblett N, Kashirskaya N, Kerem E, Mathew JL, McKone EF, Naehrlich L, Nasr SZ, Oates GR, O'Neill C, Pypops U, Raraigh KS, Rowe SM, Southern KW, Sivam S, Stephenson AL, Zampoli M, Ratjen F

The future of cystic fibrosis care: A global perspective.

Lancet Respir Med. 2020 Jan;8(1):65-124.

Mall MA, Mayer-Hamblett N, Rowe SM

Cystic fibrosis: Emergence of highly effective targeted therapeutics and potential clinical implications.

Am J Respir Crit Care Med. 2019 Dec 20

Matos ADR, Wunderlich K, Schloer S, Schughart K, Geffers R, Seders M, Witt M, Christersson A, Wiewrodt R, Wiebe K, Barth P, Hocke A, Hippenstiel S, Hönzke K, Dittmer U, Sutter K, Rescher U, Rodionycheva S, Matera N, Ludwig S, Brunotte L.

Antiviral potential of human IFN-α subtypes against influenza A H3N2 infection in human lung explants reveals subtype-specific activities

Emerg Microbes Infect. 2019; 8(1): 1763–1776.

Fritsch VN, Loi VV, Busche T, Sommer A, Tedin K, Nürnberg DJ, Kalinowski J, Bernhardt J, Fulde M, Antelmann H

The MarR-Type Repressor MhqR Confers Quinone and Antimicrobial Resistance in Staphylococcus aureus

Antioxid Redox Signal. 2019 Dec 1;31(16):1235-1252. doi: 10.1089/ars.2019.7750.

Balazs A, Mall MA

Mucus obstruction and inflammation in early cystic fibrosis lung disease: Emerging role of the IL-1 signaling pathway.

Pediatr Pulmonol. 2019 Nov;54 Suppl 3:S5-S12.

 

Frantz R, Teubner L, Schultze T, La Pietra L, Müller C, Gwozdzinski K, Pillich H, Hain T, Weber-Gerlach M, Panagiotidis GD, Mostafa A, Weber F, Rohde M, Pleschka S, Chakraborty T, Abu Mraheil M.

The secRNome of Listeria monocytogenes Harbors Small Noncoding RNAs That Are Potent Inducers of Beta Interferon.

mBio. 2019. 10(5):e01223-19.

Schmoldt C, Vazquez-Armendariz AI, Shalashova I, Selvakumar B, Bremer CM, Peteranderl C, Witte B, Gattenloehner S, Fink L, Vadasz I, Morty RE, Pleschka S, Seeger W, Günther A, Herold S

IRE-1 signaling as putative therapeutic target in influenza virus-induced pneumonia.

Am J Respir Cell Mol Biol. 2019 Oct;61(4):537-540.

Dabrowski AN, Shrivastav A, Conrad C, Komma K, Weigel M, Dietert K, Gruber A, Bertrams W, Wilhelm J, Schmeck B, Reppe K, N'Guessan PD, Aly S, Suttorp N, Hain T, Zahlten J.

Peptidoglycan recognition protein 4 limits bacterial clearance and inflammation in lungs by control of the gut microbiota.

Front Immunol. 2019 Sep 20;10:2106

https://www.ncbi.nlm.nih.gov/pubmed/31616404

Peteranderl C, Kuznetsova I, Schulze J, Hardt M, Lecuona E, Sznajder JI,  Vadász I, Morty RE, Pleschka S, Wolff T, Herold S

Influenza A virus infection induces apical redistribution of Na+, K+-ATPase in lung epithelial cells in vitro and in vivo.

Am J Respir Cell Mol Biol. 2019 Sep;61(3):395-398.

Loi VV, Huyen NTT, Busche T, Tung QN, Gruhlke MCH, Kalinowski J, Bernhardt J, Slusarenko AJ, Antelmann H.

Staphylococcus aureus responds to allicin by global S-thioallylation - Role of the Brx/BSH/YpdA pathway and the disulfide reductase MerA to overcome allicin stress

Free Radic Biol Med. 2019 Aug 1;139:55-69. doi: 10.1016/j.freeradbiomed.2019.05.018.

Lippitsch A, Baal N, Chukovetskyi Y, Cunningham S, Michel G, Dietert K, Gurtner C, Gruber AD, Bein G, Hackstein H

Plasmacytoid dendritic cell depletion modifies FoxP3+ T cell homeostasis and the clinical course of bacterial pneumonia in mice.

J Leukoc Biol. 2019 Jul 2

https://www.ncbi.nlm.nih.gov/pubmed/31265764

Linzner N, Loi VV, Fritsch VN, Tung QN, Stenzel S, Wirtz M, Hell R, Hamilton C, Tedin K, Fulde M, Antelmann H.

Staphylococcus aureus Uses the Bacilliredoxin (BrxAB)/Bacillithiol Disulfide Reductase (YpdA) Redox Pathway to Defend Against Oxidative Stress Under Infections

Front Microbiol. 2019 Jun 18;10:1355. doi: 10.3389/fmicb.2019.01355.

Amarelle L, Katzen J, Shigemura M, Welch LC, Cajigas H, Peteranderl C, Celli D, Herold S, Lecuona E, Szanjder JI

Cardiac glycosides decrease influenza virus replication by inhibiting cell protein translational machinery.

Am J Physiol Lung Cell Mol Physiol. 2019 Jun 1;316(6):L1094-L1106.

Scheller N, Herold S, Kellner R, Bertrams W, Jung AL, Janga H, Greulich T, Schulte LN, Vogelmeier CF, Lohmeyer J, Schmeck B

Proviral MicroRNAs Detected in Extracellular Vesicles From Bronchoalveolar Lavage Fluid of Patients With Influenza Virus-Induced Acute Respiratory Distress Syndrome.

J Infect Dis. 2019 Jan 29;219(4):540-543

https://www.ncbi.nlm.nih.gov/pubmed/30239899

Tung QN, Loi VV, Busche T, Nerlich A, Mieth M, Milse J, Kalinowski J, Hocke AC, Antelmann H.

Stable integration of the Mrx1-roGFP2 biosensor to monitor dynamic changes of the mycothiol redox potential in Corynebacterium glutamicum

Redox Biol. 2019 Jan;20:514-525

Grund C, Hoffmann D, Ulrich R, Naguib M, Schinköthe J, Hoffmann B, Harder T, Saenger S, Zscheppang K, Tönnies M, Hippenstiel S, Hocke A, Wolff T, Beer M.

A novel European H5N8 influenza A virus has increased virulence in ducks but low zoonotic potential

Emerg Microbes Infect. 2018 Jul 19;7(1):132.

Kalymbetova TV, Selvakumar B, Rodriguez-Castillo JA, Gunjak M, Malainou C, Heindl MR, Moiseenko A, Chao CM, Vadasz I, Mayer K, Lohmeyer J, Bellusci S, Bottcher-Friebertshauser E, Seeger W, Herold S, Morty RE

Resident alveolar macrophages are master regulators of arrested alveolarization in experimental bronchopulmonary dysplasia.

J Pathol. 2018 Jun;245(2):153-159

https://onlinelibrary.wiley.com/doi/epdf/10.1002/path.5076

Herta T, Bhattacharyya A, Bollensdorf C, Kabus C, García P, Suttorp N, Hippenstiel S, Zahlten J

DNA-release by Streptococcus pneumoniae autolysin LytA induced Krueppel-like factor 4 expression in macrophages.

Sci Rep. 2018 Apr 10;8(1):5723

https://www.ncbi.nlm.nih.gov/pubmed/29636524

Perniss A, Schmidt N, Gurtner C, Dietert K, Schwengers O, Weigel M, Hempe J, Ewers C, Pfeil U, Gärtner U, Gruber AD, Hain T, Kummer W

Bordetella pseudohinzii targets cilia and impairs tracheal cilia-driven transport in naturally acquired infection in mice.

Sci Rep. 2018 Apr 9;8(1):5681

http://www.nature.com/articles/s41598-018-23830-4

Dittrich AS, Kühbandner I, Gehrig S, Rickert-Zacharias V, Twigg M, Wege S, Taggart CC, Herth F, Schultz C, Mall MA

Elastase activity on sputum neutrophils correlates with severity of lung disease in cystic fibrosis.

Eur Respir J. 2018 Mar 29;51(3). pii: 1701910

https://www.ncbi.nlm.nih.gov/pubmed/29545279

Ugolini M, Gerhard J, Burkert S, Jensen KJ, Georg P, Ebner F, Thada S, Dietert K, Helbig ET, Opitz B, Kurth F, Dittrich N, Sumanlatha G, Blander JM, Gruber AD, Hartmann S, Boekschoten MV, Suttorp N, Müller M, Jungersen G, Schumann RR, Sander LE

Recognition of microbial viability via TLR8 promotes T follicular helper cell differentiation and vaccine responses.

Nat Immunol  2018

https://www.nature.com/articles/s41590-018-0068-4

Dames C, Winek K, Beckers Y, Engel O, Meisel M, Meisel C

Immunomodulatory treatment with systemic GM-CSF augments pulmonary immune responses and improves neurological outcome after experimental stroke.

J Neuroimmunol. 2018 Mar 9. pii: S0165-5728(17)30548-9

http://www.jni-journal.com/article/S0165-5728(17)30548-9/fulltext

Tung QN, Linzner N, Loi VV, Antelmann H

Application of genetically encoded redox biosensors to measure dynamic changes in the glutathione, bacillithiol and mycothiol redox potentials in pathogenic bacteria.

Free Radic Biol Med. 2018 Feb 15. pii: S0891-5849(18)30073-X.

https://www.sciencedirect.com/science/article/pii/S089158491830073X?via%3Dihub

Gutbier B, Neuhauß AK, Reppe K, Ehrler C, Santel A, Kaufmann J, Scholz M, Weissmann N, Morawietz L, Mitchell TJ, Aliberti S, Hippenstiel S, Suttorp N, Witzenrath M; CAPNETZ and PROGRESS study groups

Prognostic and Pathogenic Role of Angiopoietin-1 and -2 in Pneumonia.

Am J Respir Crit Care Med. 2018 Feb 15

https://www.ncbi.nlm.nih.gov/pubmed/29447449

Shrivastav A, Dabrowski AN, Conrad C, Baal N, Hackstein H, Plog S, Dietert K, Gruber AD, N'Guessan PD, Aly S, Suttorp N, Zahlten J

Peptidoglycan Recognition Protein 3 Does Not Alter the Outcome of Pneumococcal Pneumonia in Mice.

Front Microbiol. 2018 Feb 1;9:103

https://www.ncbi.nlm.nih.gov/pubmed/29449834

Becker SC, Szyska M, Mensen A, Hellwig K, Otto R, Olfe L, Volk HD, Dörner T, Dörken B, Scheibenbogen C, Schröder J, Hocke AC, Kang Na Il

A comparative analysis of human bone marrow-resident and peripheral memory B cells.

J Allergy Clin Immunol. 2018 Jan 31

https://www.ncbi.nlm.nih.gov/pubmed/29355676

Dietert K, Nouailles G, Gutbier B, Reppe K, Berger S, Jiang X, Schauer AE, Hocke AC, Herold S, Slevogt H, Witzenrath M, Suttorp N, Gruber AD

Digital Image Analyses on Whole Lung Slides in Mouse Models of Acute Pneumonia.

Am J Respir Cell Mol Biol. 2018 Jan 23.

https://www.atsjournals.org/doi/full/10.1165/rcmb.2017-0337MA

Nerlich A, Mieth M, Letsiou E, Fatykhova D, Zscheppang K, Matsushima AI, Meyer TF, Paasch L, Mitchell T, Tönnies M, Bauer TT, Schneider P, Neudecker J, Rückert J, Eggeling S, Schimek M, Witzenrath M, Suttorp N, Hippenstiel S, Hocke AC

Pneumolysin induced mitochondrial dysfunction leads to release of mitochondrial DNA.

Scientific Reports (2018) 8:182

https://www.nature.com/articles/s41598-017-18468-7

Gutbier B, Schönrock SM, Ehrler C, Haberberger R, Dietert K, Gruber AD, Kummer W, Michalik L, Kübler WM, Hocke AC, Szymanski K, Letsiou E, Lüth A, Schumacher F, Kleuser B, Mitchell TJ, Bertrams W, Schmeck B, Treue D, Klauschen F, Bauer TT, Tönnies M,

Sphingosine kinase 1 regulates inflammation and contributes to acute lung injury in pneumococcal pneumonia via the S1P receptor 2.

Crit Care Med. 2018 Jan 2.

https://www.ncbi.nlm.nih.gov/pubmed/29298188

Boutin S, Depner M, Stahl M, Graeber SY, Dittrich SA, Legatzki A, von Mutius E, Mall M, Dalpke AH

Comparison of Oropharyngeal Microbiota from Children with Asthma and Cystic Fibrosis.

Mediators Inflamm. 2017;2017:5047403

https://www.ncbi.nlm.nih.gov/pubmed/29445257

Heß N, Waldow F, Kohler TP, Rohde M, Kreikemeyer B, Gómez-Mejia A, Hain T, Schwudke D, Vollmer W, Hammerschmidt S, Gisch N

LTA deficiency permits normal growth but impairs virulence of Streptococcus pneumoniae.

Nat Commun. 2017 Dec 12;8(1):2093

https://www.ncbi.nlm.nih.gov/pubmed/29233962

Horn V, Triantafyllopoulou A

DNA damage signaling and polyploid macrophages in chronic inflammation.

Curr Opin Immunol. 2017 Dec 1;50:55-63

https://www.ncbi.nlm.nih.gov/pubmed/29202328

Dietert K, Gutbier B, Wienhold SM, Reppe K, Jiang X, Yao L, Chaput C, Naujoks J, Brack M, Kupke A, Peteranderl C, Becker S, von Lachner C, Baal N, Slevogt H, Hocke AC, Witzenrath M, Opitz B, Herold S, Hackstein H, Sander LE, Suttorp N, Gruber AD

Spectrum of pathogen- and model-specific histopathologies in mouse models of acute pneumonia.

PLoS One. 2017 Nov 20;12(11):e0188251

https://www.ncbi.nlm.nih.gov/pubmed/29155867

van de Sandt CE, Bárcena M, Koster AJ, Kasper J, Kirkpatrick CJ, Scott DP, de Vries RD, Herold S, Rimmelzwaan GF, Kuiken T, Short KR

Human CD8+ T Cells Damage Noninfected Epithelial Cells during Influenza Virus Infection In Vitro.

Am J Respir Cell Mol Biol. 2017 Nov;57(5):536-546

https://www.ncbi.nlm.nih.gov/pubmed/28613916

Boutin S, Graeber SY, Stahl M, Dittrich AS, Mall MA, Dalpke AH

Chronic but not intermittent infection with Pseudomonas aeruginosa is associated with global changes of the lung microbiome in cystic fibrosis.

Eur Respir J. 2017 Oct 5;50(4)

https://www.ncbi.nlm.nih.gov/pubmed/28982777

Schulz C, Lai X, Bertrams W, Jung AL, Sittka-Stark A, Herkt CE, Janga H, Zscheppang K, Stielow C, Schulte L, Hippenstiel S, Vera J, Schmeck B

THP-1-derived macrophages render lung epithelial cells hypo-responsive to Legionella pneumophila - a systems biology study.

Sci Rep. 2017 Sep 20;7(1):11988

https://www.ncbi.nlm.nih.gov/pubmed/28931863

Zscheppang K, Berg J, Hedtrich S, Verheyen L, Wagner DE, Suttorp N, Hippenstiel S, Hocke AC

Human pulmonary 3D models for translational research.

Biotechnol J. 2017 Sep 2

https://www.ncbi.nlm.nih.gov/pubmed/28865134

Wygrecka M, Kosanovic D, Wujak L, Reppe K, Henneke I, Frey H, Didiasova M, Kwapiszewska G, Marsh LM, Baal N, Hackstein H, Zakrzewicz D, Müller-Redetzky HC, de Maat S, Maas C, Nolte MW, Panousis C, Schermuly RT, Seeger W, Witzenrath M, Schaefer L, Markart

Antihistone Properties of C1 Esterase Inhibitor Protect against Lung Injury.

Am J Respir Crit Care Med. 2017 Jul 15;196(2):186-199

https://www.ncbi.nlm.nih.gov/pubmed/28005404

Berg J, Zscheppang K, Fatykhova D, Tönnies M, Bauer TT, Schneider P, Neudecker J, Rückert JC, Eggeling S, Schimek M, Gruber AD, Suttorp N, Hippenstiel S, Hocke AC

Tyk2 as a target for immune regulation in human viral/bacterial pneumonia.

Eur Respir J. 2017 Jul 13;50(1)

http://erj.ersjournals.com/content/50/1/1601953

Peter A, Fatykhova D, Kershaw O, Gruber AD, Rueckert J, Neudecker J, Toennies M, Bauer TT, Schneider P, Schimek M, Eggeling S, Suttorp N, Hocke AC, Hippenstiel S

Localization and pneumococcal alteration of junction proteins in the human alveolar-capillary compartment.

Histochem Cell Biol. 2017 Jun;147(6):707-719

https://www.ncbi.nlm.nih.gov/pubmed/28247028

Lippitsch A, Chukovetskyi Y, Baal N, Bein G, Hackstein H

Unique high and homogenous surface expression of the transferrin receptor CD71 on murine plasmacytoid dendritic cells in different tissues.

Cell Immunol. 2017 Jun;316:41-52

https://doi.org/10.1016/j.cellimm.2017.03.005

Gerlach T, Hensen L, Matrosovich T, Bergmann J, Winkler M, Peteranderl C, Klenk HD, Weber F, Herold S, Pöhlmann S, Matrosovich M

pH Optimum of Hemagglutinin-Mediated Membrane Fusion Determines Sensitivity of Influenza A Viruses to the Interferon-Induced Antiviral State and IFITMs.

J Virol. 2017 May 12;91(11). pii: e00246-17

https://www.ncbi.nlm.nih.gov/pubmed/28356532

Peteranderl C, Sznajder JI, Herold S and Lecuona E

Inflammatory responses regulating alveolar ion transport during pulmonary infections.

Front Immunol. 2017 Apr 18;8:446

https://www.ncbi.nlm.nih.gov/pubmed/28458673

Peteranderl C, Herold S

The Impact of the Interferon/TNF-Related Apoptosis-Inducing Ligand Signaling Axis on Disease Progression in Respiratory Viral Infection and Beyond.

Front Immunol. 2017 Mar 22;8:313

https://www.ncbi.nlm.nih.gov/pubmed/28382038

Sadewasser A, Paki K, Eichelbaum K, Bogdanow B, Saenger S, Budt M, Lesch M, Hinz KP, Herrmann A, Meyer TF, Karlas A, Selbach M, Wolff T

Quantitative proteomic approach identifies Vpr binding protein as novel host factor supporting influenza A virus infections in human cells.

Mol Cell Proteomics. 2017 Mar 13

https://www.ncbi.nlm.nih.gov/pubmed/28289176

Schierhorn KL, Jolmes F, Bespalowa J, Saenger S, Peteranderl C, Dzieciolowski J, Budt M, Pleschka S, Herrmann A, Herold S, Wolff T

Influenza A virus virulence depends on two amino acids in the N-terminal domain of its NS1 protein facilitating inhibition of PKR.

J Virol. 2017 Mar 1. pii: JVI.00198-17

https://www.ncbi.nlm.nih.gov/pubmed/28250123

Hocke AC, Suttorp N, and Hippenstiel S

Human lung ex vivo infection models.

Cell Tissue Res. 2017 Mar;367(3):511-524

https://www.ncbi.nlm.nih.gov/pubmed/27999962

Chao CM, Yahya F, Moiseenko A, Tiozzo C, Shrestha A, Ahmadvand N, El Agha E, Quantius J, Dilai S, Kheirollahi V, Jones M, Wilhem J, Carraro G, Ehrhardt H, Zimmer KP, Barreto G, Ahlbrecht K, Morty RE, Herold S, Abellar RG, Seeger W, Schermuly R, Zhang JS,

Fgf10 deficiency is causative for lethality in a mouse model of bronchopulmonary dysplasia.

J Pathol. 2017 Jan;241(1):91-103

https://www.ncbi.nlm.nih.gov/pubmed/27770432

Schaefer MB, Schaefer CA, Schifferings S, Kuhlmann CR, Urban A, Benscheid U, Fischer T, Hecker M, Morty RE, Vadasz I, Herold S, Witzenrath M, Seeger W, Erdogan A, Mayer K

N-3 vs. n-6 fatty acids differentially influence calcium signalling and adhesion of inflammatory activated monocytes: impact of lipid rafts.

Inflamm Res. 2016 Nov;65(11):881-894

https://www.ncbi.nlm.nih.gov/pubmed/27384606

Peteranderl C, Herold S, Schmoldt C

Human Influenza Virus Infections.

Semin Respir Crit Care Med. 2016 Aug;37(4):487-500

https://www.ncbi.nlm.nih.gov/pubmed/27486731

Rabes A, Suttorp N, Opitz B

Inflammasomes in Pneumococcal Infection: Innate Immune Sensing and Bacterial Evasion Strategies.

Curr Top Microbiol Immunol. 2016;397:215-27

https://www.ncbi.nlm.nih.gov/pubmed/27460812

Hackstein H, Tschipakow I, Bein G, Nold P, Brendel C, Baal N

Contact-dependent abrogation of bone marrow-derived plasmacytoid dendritic cell differentiation by murine mesenchymal stem cells.

Biochem Biophys Res Commun. 2016 Jul 15;476(1):15-20

https://www.ncbi.nlm.nih.gov/pubmed/27233615

Quantius J, Schmoldt C, Vazquez-Armendariz AI, Becker C, El Agha E, Wilhelm J, Morty RE, Vadász I, Mayer K, Gattenloehner S, Fink L, Matrosovich M, Li X, Seeger W, Lohmeyer J, Bellusci S, Herold S

Influenza Virus Infects Epithelial Stem/Progenitor Cells of the Distal Lung: Impact on Fgfr2b-Driven Epithelial Repair.

PLoS Pathog. 2016 Jun 20;12(6):e1005544

https://www.ncbi.nlm.nih.gov/pubmed/27322618

Mostafa A, Abdelwhab el-SM, Slanina H, Hussein MA, Kuznetsova I, Schüttler CG, Ziebuhr J, Pleschka S

Phylogenetic analysis of human influenza A/H3N2 viruses isolated in 2015 in Germany indicates significant genetic divergence from vaccine strains.

Arch Virol. 2016 Jun;161(6):1505-15

http://www.ncbi.nlm.nih.gov/pubmed/26973232

Winek K, Engel O, Koduah P, Heimesaat MM, Fischer A, Bereswill S, Dames C, Kershaw O, Gruber AD, Curato C, Oyama N, Meisel C, Meisel A, Dirnagl U

Depletion of cultivatable gut microbiota by broad-spectrum antibiotic pretreatment worsens outcome after murine stroke.

Stroke. 2016 May;47(5):1354-63

https://www.ncbi.nlm.nih.gov/pubmed/27056982

Winek K, Engel O, Koduah P, Heimesaat MM, Fischer A, Bereswill S, Dames C, Kershaw O, Gruber AD, Curato C, Oyama N, Meisel C, Meisel A, Dirnagl U

Depletion of cultivatable gut microbiota by broad-spectrum antibiotic pretreatment worsens outcome after murine stroke.

Stroke. 2016 May;47(5):1354-63

https://www.ncbi.nlm.nih.gov/pubmed/27056982

Peteranderl C, Morales-Nebreda L, Selvakumar B, Lecuona E, Vadász I, Morty RE, Schmoldt C, Bespalowa J, Wolff T, Pleschka S, Mayer K, Gattenloehner S, Fink L, Lohmeyer J, Seeger W, Sznajder JI, Mutlu GM, Budinger GR, Herold S

Macrophage-epithelial paracrine crosstalk inhibits lung edema clearance during influenza infection.

J Clin Invest. 2016 Apr 1;126(4):1566-80

http://www.ncbi.nlm.nih.gov/pubmed/26999599

Griss K, Bertrams W, Sittka-Stark A, Seidel K, Stielow C, Hippenstiel S, Suttorp N, Eberhardt M, Wilhelm J, Vera J, Schmeck B

MicroRNAs constitute a negative feedback loop in Streptococcus pneumoniae induced macrophage activation.

J Infect Dis. 2016 Mar 16

http://www.ncbi.nlm.nih.gov/pubmed/26984146

Short K, Kasper J, van der Aa S, Andeweg AC, Zaaraoui-Boutahar F, Goeijenbier M, Richard M, Herold S, Becker C, Scott DP, Limpens R, Koster AJ, Barcena M, Fouchier R, Kirkpatrick CJ, Kuiken T

Influenza virus damages the alveolar barrier by disrupting epithelial cell tight junctions.

Eur Respir J. 2016 Mar;47(3):954-66

https://www.ncbi.nlm.nih.gov/pubmed/ 26743480

Naujoks J, Tabeling C, Dill BD, Hoffmann C, Brown AS, Kunze M, Kempa S, Peter A, Mollenkopf HJ, Dorhoi A, Kershaw O, Gruber AD, Sander LE, Witzenrath M, Herold S, Nerlich A, Hocke AC, van Driel I, Suttorp N, Bedoui S, Hilbi H, Trost M, Opitz B

IFNs Modify the Proteome of Legionella-Containing Vacuoles and Restrict Infection Via IRG1-Derived Itaconic Acid.

PLoS Pathog. 2016 Feb 1;12(2)

https://www.ncbi.nlm.nih.gov/pubmed/26829557

Hoffmann S, Harms H, Ulm L, Nabavi DG, Mackert BM, Schmehl I, Jungehulsing GJ, Montaner J, Bustamante A, Hermans M, Hamilton F, Göhler J, Malzahn U, Malsch C, Heuschmann PU, Meisel C, Meisel A

Stroke-induced immunodepression and dysphagia independently predict stroke-associated pneumonia - The PREDICT study.

J Cereb Blood Flow Metab. 2016 Jan 1:271678X16671964

https://www.ncbi.nlm.nih.gov/pubmed/27733675

Reppe K, Radünzel P, Dietert K, Tschernig T, Wolff T, Hammerschmidt S, Gruber AD, Suttorp N, Witzenrath M

Pulmonary immunostimulation with MALP-2 in influenza virus-infected mice increases survival after pneumococcal superinfection.

Infect Immun. 2015 Dec;83(12):4617-29

https://www.ncbi.nlm.nih.gov/pubmed/26371127

Meisel A, Smith CJ

Stroke: Preventive antibiotics for stroke-associated pneumonia.

Nat Rev Neurol. 2015 Nov 3

http://www.ncbi.nlm.nih.gov/pubmed/26526533

Engel O, Akyüz L, da Costa Goncalves AC, Winek K, Dames C, Thielke M, Herold S, Böttcher C, Priller J, Volk HD, Dirnagl U, Meisel C, Meisel A

Cholinergic pathway suppresses pulmonary innate immunity facilitating pneumonia after stroke.

Stroke. 2015 Nov;46(11):3232-40

http://www.ncbi.nlm.nih.gov/pubmed/26451017

Hackstein H, Lippitsch A, Krug P, Schevtschenko I, Kranz S, Hecker M, Dietert K, Gruber AD, Bein G, Brendel C, Baal N

Prospectively defined murine mesenchymal stem cells inhibit Klebsiella pneumoniae-induced acute lung injury and improve pneumonia survival.

Respir Res. 2015 Oct 6;16:123

https://www.ncbi.nlm.nih.gov/pubmed/26438075

Zahlten J, Herta T, Kabus C, Steinfeldt M, Kershaw O, García P, Hocke AC, Gruber AD, Hübner RH, Steinicke R, Doehn JM, Suttorp N, Hippenstiel S

Role of Pneumococcal Autolysin for KLF4 Expression and Chemokine Secretion in Lung Epithelium.

Am J Respir Cell Mol Biol. 2015 Oct;53(4):544-54

https://www.ncbi.nlm.nih.gov/pubmed/ 25756955

Meisel A, Smith CJ

Prevention of stroke-associated pneumonia: where next?

Lancet. 2015 Sep 3. pii: S0140-6736(15)00127-0

http://www.ncbi.nlm.nih.gov/pubmed/26343837

Fatykhova D, Rabes A, Machnik C, Guruprasad K, Pache F, Berg J, Toennies M, Bauer TT, Schneider P, Schimek M, Eggeling S, Mitchell TJ, Mitchell AM, Hilker R, Hain T, Suttorp N, Hippenstiel S, Hocke AC, Opitz B

Serotype 1 and 8 Pneumococci Evade Sensing by Inflammasomes in Human Lung Tissue.

PLoS One. 2015 Aug 28;10(8):e0137108

https://www.ncbi.nlm.nih.gov/pubmed/26317436

Recum-Knepper J, Sadewasser A, Weinheimer VK, Wolff T

Fluorescence-Activated Cell Sorting-Based Analysis Reveals an Asymmetric Induction of Interferon-Stimulated Genes in Response to Seasonal Influenza A Virus.

J Virol. 2015 Jul 15;89(14):6982-93

http://www.ncbi.nlm.nih.gov/pubmed/25903337

Smith CJ, Kishore AK, Vail A, Chamorro A, Garau J, Hopkins SJ, Di Napoli M, Kalra L, Langhorne P, Montaner J, Roffe C, Rudd AG, Tyrrell PJ, van de Beek D, Woodhead M, Meisel A.

Diagnosis of Stroke-Associated Pneumonia: Recommendations From the Pneumonia in Stroke Consensus Group.

Stroke. 2015 Jun 25. pii: STROKEAHA.115.009617.

http://www.ncbi.nlm.nih.gov/pubmed/26111886

Mühlbauer D, Dzieciolowski J, Hardt M, Hocke A, Schierhorn KL, Mostafa A, Müller C, Wisskirchen C, Herold S, Wolff T, Ziebuhr J, Pleschka S

Influenza virus-induced caspase-dependent enlargement of nuclear pores promotes nuclear export of viral ribonucleoprotein complexes.

J Virol. 2015 Jun 1;89(11):6009-21

http://www.ncbi.nlm.nih.gov/pubmed/25810542

Jung S, von Thulen T, Laukemper V, Pigisch S, Hangel D, Wagner H, Kaufmann A, Bauer S

A single naturally occurring 2'-O-methylation converts a TLR7- and TLR8-activating RNA into a TLR8-specific ligand.

A single naturally occurring 2'-O-methylation converts a TLR7- and TLR8-activating RNA into a TLR8-specific ligand.

https://www.ncbi.nlm.nih.gov/pubmed/25785446

Hecker M, Linder T, Ott J, Walmrath HD, Lohmeyer J, Vadász I, Marsh LM, Herold S, Reichert M, Buchbinder A, Morty RE, Bausch B, Fischer T, Schulz R, Grimminger F, Witzenrath M, Barnes M, Seeger W, Mayer K

Immunomodulation by lipid emulsions in pulmonary inflammation: a randomized controlled trial.

Crit Care. 2015 May 12;19:226

http://www.ncbi.nlm.nih.gov/pubmed/25962383

Müller-Redetzky HC, Wienhold SM, Berg J, Hocke AC, Hippenstiel S, Hellwig K, Gutbier B, Opitz B, Neudecker J, Rückert J, Gruber AC, Kershaw O, Mayer K,  Suttorp N, Witzenrath M

Moxifloxacin is not anti-inflammatory in experimental pneumococcal pneumonia.

J Antimicrob Chemother. 2015 Mar;70(3):830-40

http://www.ncbi.nlm.nih.gov/pubmed/25406299

Kishore AK, Vail A, Chamorro A, Garau J, Hopkins SJ, Di Napoli M, Kalra L, Langhorne P, Montaner J, Roffe C, Rudd AG, Tyrrell PJ, van de Beek D, Woodhead M, Meisel A, Smith CJ

How is pneumonia diagnosed in clinical stroke research? A systematic review and meta-analysis.

Stroke. 2015 May;46(5):1202-9.

http://www.ncbi.nlm.nih.gov/pubmed/25858238

Meisel A

Preventive antibiotic therapy in stroke: PASSed away?

Lancet. 2015 Apr 18;385(9977):1486-7

http://www.ncbi.nlm.nih.gov/pubmed/25612859

Tabeling C, Yu H, Wang L, Ranke H, Goldenberg NM, Zabini D, Noe E, Krauszman A, Gutbier B, Yin J, Schaefer M, Arenz C, Hocke AC, Suttorp N, Proia RL, Witzenrath M, Kuebler WM

CFTR and sphingolipids mediate hypoxic pulmonary vasoconstriction.

Proc Natl Acad Sci U S A. 2015 Mar 31;112(13):E1614-23

http://www.ncbi.nlm.nih.gov/pubmed/25829545

Zahlten J, Herta T, Kabus C, Steinfeldt M, Kershaw O, García P, Hocke AC, Gruber AD, Hübner RH, Steinicke R, Doehn JM, Suttorp N, Hippenstiel S

Pneumococci LytA-dependent KLF4 Expression Terminates IL-8 Secretion in Lung Epithelium.

Am J Respir Cell Mol Biol. 2015 Mar 10

http://www.ncbi.nlm.nih.gov/pubmed/25756955

Rabes A, Zimmermann S, Reppe K, Lang R, Seeberger PH, Suttorp N, Witzenrath M, Lepenies B, Opitz B

The C-type lectin receptor Mincle binds to Streptococcus pneumoniae but plays a limited role in the anti-pneumococcal innate immune response.

PLoS One. 2015 Feb 6;10(2):e0117022

http://www.ncbi.nlm.nih.gov/pubmed/25658823

Müller-Redetzky HC, Felten M, Hellwig K, Wienhold SM, Naujoks J, Opitz B, Kershaw O, Gruber AD, Suttorp N, Witzenrath M

Increasing the inspiratory time and I:E ratio during mechanical ventilation aggravates ventilator-induced lung injury in mice.

Critical Care 2015, 19:23

http://www.ncbi.nlm.nih.gov/pubmed/25888164

Zahlten J, Kim YJ, Doehn JM, Pribyl T, Hocke AC, García P, Hammerschmidt S, Suttorp N, Hippenstiel S, Hübner RH

Streptococcus pneumoniae-Induced Oxidative Stress in Lung Epithelial Cells Depends on Pneumococcal Autolysis and Is Reversible by Resveratrol.

J Infect Dis. 2015 Jun 1;211(11):1822-1830

http://www.ncbi.nlm.nih.gov/pubmed/25512625

Dames C, Akyüz L, Reppe K, Tabeling C, Dietert K, Kershaw O, Gruber AD, Meisel C, Meisel A, Witzenrath M, Engel O

Miniaturized bronchoscopy enables unilateral investigation, application, and sampling in mice.

Am J Respir Cell Mol Biol. 2014 Dec;51(6):730-7

http://www.ncbi.nlm.nih.gov/pubmed/24960575

Noe E, Tabeling C, Doehn JM, Naujoks J, Opitz B, Hippenstiel S, Witzenrath M, Klopfleisch R

Juvenile megaesophagus in PKCα-deficient mice is associated with an increase in the segment of the distal esophagus lined by smooth muscle cells.

Ann Anat. 2014 Sep;196(5):365-71

https://www.ncbi.nlm.nih.gov/pubmed/24862691

Hecker M, Ott J, Sondermann C, Schaefer M, Obert M, Hecker A, Morty RE, Vadasz I, Herold S, Rosengarten B, Witzenrath M, Seeger W, Mayer K

Immunomodulation by fish-oil containing lipid emulsions in murine acute respiratory distress syndrome.

Crit Care. 2014 Apr 29;18(2):R85

http://www.ncbi.nlm.nih.gov/pubmed/24780004

Peters DM, Vadász I, Wujak L, Wygrecka M, Olschewski A, Becker C, Herold S, Papp

TGF-ß directs trafficking of the epithelial sodium channel ENaC which has implications for ion and fluid transport in acute lung injury.

Proc Natl Acad Sci U S A. 2014 Jan 21;111(3):E374-83

http://www.ncbi.nlm.nih.gov/pubmed/24324142

Herold S, Hoegner K, Vadász I, Gessler T, Wilhelm J, Mayer K, Morty RE, Walmrath

Inhaled GM-CSF as treatment of pneumonia-associated ARDS

Am J Respir Crit Care Med. 2014 Mar 1;189(5):609-11

Malczyk M, Veith C, Fuchs B, Hofmann K, Storch U, Schermuly RT, Witzenrath M, Ah

Classical Transient Receptor Potential Channel 1 in Hypoxia-induced Pulmonary Hypertension.

Am J Respir Crit Care Med. 2013 Dec 15;188(12):1451-9.

http://www.ncbi.nlm.nih.gov/pubmed/24251695

Schütz F, Hackstein H

Identification of novel dendritic cell subset markers in human blood.

Biochem Biophys Res Commun. 2013 Dec 7. pii: S0006-291X(13)02024-X. doi: 10.1016/j.bbrc.2013.11.112.

http://www.ncbi.nlm.nih.gov/pubmed/24321550

Witsch TJ, Turowski P, Sakkas E, Niess G, Becker S, Herold S, Mayer K, Vadász I, Roberts JD Jr, Seeger W, Morty RE.

Deregulation of the lysyl hydroxylase matrix cross-linking system in experimental and clinical bronchopulmonary dysplasia.

Am J Physiol Lung Cell Mol Physiol. 2013 Nov 27.

http://www.ncbi.nlm.nih.gov/pubmed/24285264

Tabeling C, Scheer H, Schönrock SM, Runge F, Gutbier B, Lienau J, Hamelmann E, Opitz B, Suttorp N, Mayer K, Behrens GM, Tschernig T, Witzenrath M.

NOD1 Ligation Suppressed Murine Allergen-Specific T Cell Proliferation and Airway Hyperresponsiveness.

Am J Respir Cell Mol Biol. 2013 Nov 26.

http://www.ncbi.nlm.nih.gov/pubmed/24279792

Chaput C, Sander LE, Suttorp N, Opitz B

NOD-Like Receptors in Lung Diseases.

Front Immunol. 2013, 4, 393.

http://www.ncbi.nlm.nih.gov/pubmed/24312100

Schwartze JT, Becker S, Sakkas E, Wujak LA, Niess G, Usemann J, Reichenberger F, Herold S, Vadasz I, Mayer K, Seeger W, Morty RE.

Glucocorticoids recruit Tgfbr3 and Smad1 to shift transforming growth factor-ß signaling from the Tgfbr1/Smad2/3 axis to the Acvrl1/Smad1 axis in lung fibroblasts.

J Biol Chem. 2013 Dec 17

http://www.ncbi.nlm.nih.gov/pubmed/24347165

Knepper J, Schierhorn KL, Becher A, Budt M, Tönnies M, Bauer TT, Schneider P, Neudecker J, Rückert JC, Gruber AD, Suttorp N, Schweiger B, Hippenstiel S, Hocke AC, Wolff T

The novel human influenza A(H7N9) virus is naturally adapted to efficient growth in human lung tissue

MBio. 2013 Oct 8;4(5). pii: e00601-13. doi: 10.1128/mBio.00601-13.

http://www.ncbi.nlm.nih.gov/pubmed/24105764

Hocke AC, Becher A, Knepper J, Peter A, Holland G, Tönnies M, Bauer TT, Schneider P, Neudecker J, Muth D, Wendtner CM, Rückert JC, Drosten C, Gruber AD, Laue M, Suttorp N, Hippenstiel S, Wolff T.

Emerging Human Middle East Respiratory Syndrome Coronavirus Causes Widespread Infection and Alveolar Damage in Human Lungs.

Am J Respir Crit Care Med. 2013 Oct 1;188(7):882-886.

http://www.ncbi.nlm.nih.gov/pubmed/24083868

Grzesik BA, Vohwinkel C, Morty RE, Mayer K, Herold S, Seeger W, Vadász I

Efficient gene delivery to primary alveolar epithelial cells by nucleofection.

Am J Physiol Lung Cell Mol Physiol 2013, 305: 786-94

http://www.ncbi.nlm.nih.gov/pubmed/24077946

Hackstein H, Kranz S, Lippitsch A, Wachtendorf A, Kershaw O, Gruber AD, Michel G, Lohmeyer J, Bein G, Baal N, Herold S.

Modulation of respiratory dendritic cells during Klebsiella pneumonia infection.

Resp Res 2013 Sept 17;14(1):91 [Epub ahead of print].

http://www.ncbi.nlm.nih.gov/pubmed/24044871

Herold S, Gabrielli NM, Vadasz I.

Novel concepts of acute lung injury and alveolo-capillary barrier dysfunction.

Am J Physiol Lung Cell Mol Physiol. 13 Sept 2013, DOI: 10.1152/ajplung.00232.2013

http://www.ncbi.nlm.nih.gov/pubmed/24039257

Bayat B, Tjahjono Y, Sydykov A, Werth S, Hippenstiel S, Weissmann N, Sachs UJ, Santoso S.

Anti-Human Neutrophil Antigen-3a Induced Transfusion-Related Acute Lung Injury in Mice by Direct Disturbance of Lung Endothelial Cells.

Arterioscler Thromb Vasc Biol. 2013 Sep 12. [Epub ahead of print]

http://www.ncbi.nlm.nih.gov/pubmed/24008160

Bakr A, Pak O, Taye A, Hamada F, Hemeida R, Janssen W, Gierhardt M, Ghofrani HA, Seeger W, Grimminger F, Schermuly RT, Witzenrath M, Brandes RP, Huang N, Cooke JP, Weissmann N, Sommer N.

Effects of dimethylarginine dimethylaminohydrolase-1 overexpression on the response of the pulmonary vasculature to hypoxia

Am J Respir Cell Mol Biol. 2013 Sep;49(3):491-500

http://www.ncbi.nlm.nih.gov/pubmed/23642043

Zahlten J, Steinicke R, Bertrams W, Hocke AC, Scharf S, Schmeck B, Witzenrath M, Hammerschmidt S, Suttorp N, Hippenstiel S.

TLR9- and Src-dependent expression of Krueppel-like factor 4 controls interleukin-10 expression in pneumonia.

Eur Respir J. 2013 Feb;41(2):384-91. Epub 2012 May 31

http://www.ncbi.nlm.nih.gov/pubmed/22653776

Hecker M, Sommer N, Voigtmann H, Pak O, Mohr A, Wolf M, Vadász I, Herold S, Weissmann N, Morty R, Seeger W, Mayer K.

Impact of Short- and Medium-Chain Fatty Acids on Mitochondrial Function in Severe Inflammation.

JPEN J Parenter Enteral Nutr. 2013 May 23.

http://www.ncbi.nlm.nih.gov/pubmed/23703093

Doehn JM, Fischer K, Reppe K, Gutbier B, Tschernig T, Hocke AC, Fischetti VA, Löffler J, Suttorp N, Hippenstiel S, Witzenrath M.

Delivery of the endolysin Cpl-1 by inhalation rescues mice with fatal pneumococcal pneumonia.

J Antimicrob Chemother. 2013 Sep;68(9):2111-7. doi: 10.1093/jac/dkt131. Epub 2013 Apr 30.

http://www.ncbi.nlm.nih.gov/pubmed/23633685

Hocke AC, Berg J, Becher A, Knepper J, Klauschen F, Tönnies M, Bauer TT, Schneider P, Neudecker J, Rückert JC, Gruber AD, Suttorp N, Hippenstiel S, Wolff T.

Reply to Fujino et al.

J Infect Dis. 2013 Feb 15;207(4):693-5. doi: 10.1093/infdis/jis740. Epub 2012 Nov 29.

http://www.ncbi.nlm.nih.gov/pubmed/23204172

Högner, K., Wolff, T., Pleschka, S.  Plog, S., Gruber, A.D., Kalinke, U., Walmrath, H.D., Bodner, J., Gattenlöhner, S., Lewe-Schlosser, P., Matrosovich, M., Seeger, W., Lohmeyer, J. and S. Herold

Macrophage-expressed IFN-ß contributes to apoptotic alveolar epithelial cell injury in severe influenza virus pneumonia.

PLoS Pathog. 2013 Feb;9(2), Epub 2013 Feb 28

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Hetze S, Engel O, Römer C, Mueller S, Dirnagl U, Meisel C, Meisel A.

Superiority of preventive antibiotic treatment compared with standard treatment of poststroke pneumonia in experimental stroke: a bed to bench approach

J Cereb Blood Flow Metab. 2013 Jan 30. doi: 10.1038/jcbfm.2013.6. [Epub ahead of print]

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Hackstein H, Hagel N, Knoche A, Kranz S, Lohmeyer J, von Wulffen W, Kershaw O, Gruber AD, Bein G, Baal N

Skin TLR7 triggering promotes accumulation of respiratory dendritic cells and natural killer cells

PLoS One, 2012;7,e43320

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Hackstein H, Wachtendorf A, Kranz S, Lohmeyer J, Bein G, Baal N

Heterogeneity of respiratory dendritic cell subsets and lymphocyte populations in inbred mouse strains

Respir Res, 2012, 13:94.

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Mergenthaler P, Meisel A.

Do stroke models model stroke?

Dis Model Mech. 2012 Nov;5(6):718-25.

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Immenschuh S, Rahayu P, Bayat B, Saragih H, Rachman A, Santoso S.

Antibodies against dengue virus nonstructural protein-1 induce heme oxygenase-1 via a redox-dependent pathway in human endothelial cells.

Free Radic Biol Med. 2012 Oct 26. PMID:23103292

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Matsuhashi M, Tsuno NH, Kawabata M, Mishima Y, Okochi N, Santoso S, Tozuka M, Takahashi K.

The frequencies of human neutrophil alloantigens among the Japanese population.

Tissue Antigens. 2012 Oct;80(4):336-40. Epub 2012 Jul 9. PMID:22776008

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Kluge S, Braune SA, Engel M, Nierhaus A, Frings D, Ebelt H, Uhrig A, Metschke M, Wegscheider K, Suttorp N, Rousseau S.

Avoiding invasive mechanical ventilation by extracorporeal carbon dioxide removal in patients failing noninvasive ventilation.

Intensive Care Med. 2012 Oct;38(10):1632-9. Epub 2012 Jul 27.

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Unkel B, Hoegner K, Clausen BE, Lewe-Schlosser P, Bodner J, Gattenloehner S, Seeger W, Lohmeyer J, Herold S

Alveolar epithelial cells orchestrate DC function in murine viral pneumonia.

J Clin Invest 2012, Oct 1;122(10):3652-64

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Pletz MW, von Baum H, van der Linden M, Rohde G, Schütte H, Suttorp N, Welte T.

The burden of pneumococcal pneumonia - experience of the German competence network CAPNETZ.

Pneumologie. 2012 Aug;66(8):470-5. Epub 2012 Aug 8.

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Weinheimer VK , Becher A, Tönnies M, Holland G, Knepper J, Bauer TT, Schneider P, Neudecker J, Rückert JC, Szymanski K, Temmesfeld-Wollbrück B, Gruber AD, Bannert N, Suttorp N, Hippenstiel S, Wolff TT, Hocke AC

Influenza a viruses target type II pneumocytes in the human lung

J Infect Dis. 2012 Dec 1;206(11):1685-94. Epub 2012 Jul 24

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Bayat B, Sachs UJ.

Transfusion-related acute lung injury: an overview.

Curr Pharm Des. 2012 July;18(22):3236-40. Review. PMID:22621272

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Chamorro Á, Meisel A, Planas AM, Urra X, van de Beek D, Veltkamp R.

The immunology of acute stroke

Nat Rev Neurol. 2012 Jun 5;8(7):401-10. doi: 10.1038/nrneurol.2012.98.

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Lepper PM, Ott S, Nüesch E, von Eynatten M, Schumann C, Pletz MW, Mealing NM, Welte T, Bauer TT, Suttorp N, Jüni P, Bals R, Rohde G; German Community Acquired Pneumonia Competence Network.

Serum glucose levels for predicting death in patients admitted to hospital for community acquired pneumonia: prospective cohort study.

BMJ. 2012 May 28;344:e3397.

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Müller-Redetzky HC, Kummer W, Pfeil U, Hellwig K, Will D, Paddenberg R, Tabeling C, Hippenstiel S, Suttorp N, Witzenrath M.

Intermedin stabilized endothelial barrier function and attenuated ventilator-induced lung injury in mice.

PLoS One. 2012;7(5):e35832. Epub 2012 May 1.

http://www.ncbi.nlm.nih.gov/pubmed/22563471

Hetze S, Römer C, Teufelhart C, Meisel A, Engel O.

Gait analysis as a method for assessing neurological outcome in a mouse model of stroke

J Neurosci Methods. 2012;206(1):7-14.

http://www.ncbi.nlm.nih.gov/pubmed/22343052

Kolditz M, Höffken G, Martus P, Rohde G, Schütte H, Bals R, Suttorp N, Pletz MW; CAPNETZ study group.

Serum cortisol predicts death and critical disease independently of CRB-65 score in community-acquired pneumonia: a prospective observational cohort study.

BMC Infect Dis. 2012 Apr 13;12:90.

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Szymanski K, Toennies M, Becher A, Fatykhova D, N’Guessan PD, Gutbier B, Klauschen F, Neuschaefer-Rube F, Schneider P, Rueckert J, Neudecker J, Bauer T, Dalhoff K, Dromann D, Gruber A, Kershaw O, Temmesfeld-Wollbrück B, Suttorp N, Hippenstiel S, Hocke

Streptococcus pneumoniae induced regulation of cyclooxygenase-2 in human lung tissue

Eur Respir J. 2012 Dec;40(6):1458-67. Epub 2012 Mar 22

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Bayat B, Tjahjono Y, Werth S, Berghöfer H, Reil A, Kroll H, Sachs UJ, Santoso S.

Implication of transfected cell lines for the detection of alloantibodies against human neutrophil antigen-3.

Transfusion. 2012 Mar;52(3):613-21. Epub 2011 Aug 24. PMID:21883263

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Jerke U, Rolle S, Dittmar G, Bayat B, Santoso S, Sporbert A, Luft F, Kettritz R.

Complement receptor Mac-1 is an adaptor for NB1 (CD177)-mediated PR3-ANCA neutrophil activation.

J Biol Chem. 2011 Mar 4;286(9):7070-81. PMID: 21193407

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Kuckleburg CJ, Tilkens SB, Santoso S, Newman PJ.

Proteinase 3 contributes to transendothelial migration of NB1-positive neutrophils.

J Immunol. 2012 Mar 1;188(5):2419-26. Epub 2012 Jan 20. PMID: 22266279

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Scharf S, Zahlten J, Szymanski K, Hippenstiel S, Suttorp N, N´Guessan PD.

Streptococcus pneumoniae induces human ß-defensin-2 and -3 in human lung epithelium.

Exp Lung Res. 2012 Mar;38(2):100-10. doi: 10.3109/01902148.2011.652802.

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Herold S, Ludwig S, Pleschka S, Wolff T

Apoptosis signaling in influenza virus propagation, innate host defence and lung injury

J Leukoc Biol. 2012 Jul;92(1):75-82. Epub 2012 Feb 17

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Koppe U, Suttorp N, Opitz B

Recognition of Streptococcus pneumoniae by the innate immune system.

Cell Microbiol. 2012 Apr;14(4):460-6. doi: 10.1111/j.1462-5822.2011.01746.x. Epub 2012 Feb 8

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Eitel J, Meixenberger K, van Laak C, Orlovski C, Hocke A, Schmeck B, Hippenstiel S, N’Guessan PD, Suttorp N, Opitz B

Rac1 regulates the NLRP3 inflammasome which mediates IL-1beta production in Chlamydophila pneumoniae infected human mononuclear cells.

PLoS One. 2012;7(1):e30379. doi: 10.1371/journal.pone.0030379. Epub 2012 Jan 20.

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Koppe U, Högner K, Witzenrath M, Bauer S, Hammerschmidt S, Suttorp N, Herold S, Opitz B.

Streptococcus pneumoniae stimulates a STING- and IFN regulatory factor 3-dependent type I IFN production in macrophages, which regulates RANTES production in macrophages, cocultured alveolar epithelial cells, and mouse lungs.

J Immunol. 2012 Jan 15;188(2):811-7

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Meisel C, Meisel A.

Suppressing immunosuppression after stroke

N Engl J Med. 2011 Dec 1;365(22):2134-6.

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Sachs UJ.

Recent insights into the mechanism of transfusion-related acute lung injury.

Curr Opin Hematol. 2011 Nov;18(6):436-42. Review. PMID:21912251

http://www.ncbi.nlm.nih.gov/pubmed/21912251

Immecke SN, Baal N, Wilhelm J, Bechtel J, Knoche A, Bein G, Hackstein H

The cyclophilin-binding agent sanglifehrin A is a dendritic cell chemokine and migration inhibitor

PlosOne 2011 Mar 31;6(3):e18406

http://www.ncbi.nlm.nih.gov/pubmed/21483789

Lippmann J, Müller H, Naujoks J, Tabeling C, Shin S, Witzenrath M, Hellwig K, Kirschning CJ, Taylor GA, Barchet W, Bauer S, Suttorp N, Roy CR, Opitz B

Dissection of a type I interferon pathway in controlling bacterial intracellular infection in mice.

Cell Microbiol. 2011 Nov;13(11):1668-82. doi: 10.1111/j.1462-5822.2011.01646.x. Epub 2011 Aug 24

http://www.ncbi.nlm.nih.gov/pubmed/21790939

Hackstein H, Knoche A, Nockher A, Jurk M, Vollmer J, Bein G

The TLR7/8 ligand resiquimod targets monocyte-derived dendritic cell differentiation via TLR8 and augments functional dendritic cell generation

Cell Immunol. 2011;271(2):401-12. doi: 10.1016/j.cellimm.2011.08.008. Epub 2011 Aug 22

http://www.ncbi.nlm.nih.gov/pubmed/21889130

Müller HC, Hocke AC, Hellwig K, Gutbier B, Peters H, Schönrock SM, Tschernig T, Schmiedl A, Hippenstiel S, N´Guessan PD, Rosseau S, Suttorp N, Witzenrath M.

The Sphingosine-1 Phosphate receptor agonist FTY720 dose dependently affected endothelial integrity in vitro and aggravated ventilator-induced lung injury in mice.

Pulm Pharmacol Ther. 2011 Aug;24(4):377-85. doi: 10.1016/j.pupt.2011.01.017. Epub 2011 Mar 23.

http://www.ncbi.nlm.nih.gov/pubmed/21419858

Tessmer A, Welte T, Schmidt-Ott R, Eberle S, Barten G, Suttorp N, Schaberg T; CAPNETZ study group.

Influenza vaccination is associated with reduced severity of community-acquired pneumonia.

Eur Respir J. 2011 Jul;38(1):147-53. Epub 2010 Dec 9.

http://www.ncbi.nlm.nih.gov/pubmed/21148226

Witzenrath M, Pache F, Lorenz D, Koppe U, Schönrock S, Meixenberger K, Dorhoi A, Ma J, Holmes A, Trendelenburg G, Heimesaat MM, Bereswill S, van der Linden M, Tschopp J, Mitchell TJ, Suttorp N, Opitz B.

The NLRP3 Inflammasome is Differentially Activated by Pneumolysin Variants and Contributes to Host Defense in Pneumococcal Pneumonia.

J Immunol. 2011 Jul 1;187(1):434-40. Epub 2011 Jun 6.

http://www.ncbi.nlm.nih.gov/pubmed/21646297

Xia W, Bayat B, Sachs U, Chen Y, Shao Y, Xu X, Deng J, Ding H, Fu Y, Ye X, Santoso S.

The frequencies of human neutrophil alloantigens in the Chinese Han population of Guangzhou.

Transfusion. 2011 Jun;51(6):1271-7. Epub 2010 Dec 16. PMID:21166683

http://www.ncbi.nlm.nih.gov/pubmed/21166683

Krasteva G, Canning BJ, Hartmann P, Veres TZ, Papadakis T, Mühlfeld C, Schliecker K, Tallini YN, Braun A, Hackstein H, Baal N, Weihe E, Schütz B, Kotlikoff M, Ibanez-Tallon I, Kummer W

Cholinergic chemosensory cells in the trachea regulate breathing.

Proc Natl Acad Sci USA. 2011, 108(23): 9478-9483

http://www.ncbi.nlm.nih.gov/pubmed/21606356

Pinto R, Herold S, Cakarova L, Hoegner K, Seeger W, Lohmeyer J, Planz O, Pleschka S

Inhibition of influenza virus-induced NF-kappaB and Raf/MEK/ERK activation can reduce both virus titers and cytokine expression simultaneously in vitro and in vivo.

Antiviral Res. 2011 Oct;92(1):45-56. Epub 2011 May 27

http://www.ncbi.nlm.nih.gov/pubmed/21641936

von Baum H, Schweiger B, Welte T, Marre R, Suttorp N, Pletz MW, Ewig S; CAPNETZ Study Group.

How deadly is seasonal influenza-associated pneumonia? The German Competence Network for Community-Acquired Pneumonia.

Eur Respir J. 2011 May;37(5):1151-7. Epub 2010 Sep 3.

http://www.ncbi.nlm.nih.gov/pubmed/20817703

Ewig S, Hecker H, Suttorp N, Marre R, Welte T; CAPNETZ study group.

Moxifloxacin monotherapy versus ß-lactam mono- or combination therapy in hospitalized patients with community-acquired pneumonia.

J Infect. 2011 Mar;62(3):218-25. Epub 2011 Jan 27.

http://www.ncbi.nlm.nih.gov/pubmed/21276814

Herold S, Tabar TS, Janßen H, Högner, K, Cabanski M, Lewe-Schlosser P, Albrecht J, Driever F, Vadasz I, Seeger W, Steinmüller M, Lohmeyer J

Exudate macrophages attenuate epithelial injury by the release of IL-1 receptor antagonist in gram-negative pneumonia.

Am J Respir Crit Care Med. 2011 May 15;183(10):1380-90. doi: 10.1164/rccm.201009-1431OC. Epub 2011 Jan 28

http://www.ncbi.nlm.nih.gov/pubmed/21278303

Eitel J, Suttorp N, Opitz B.

Innate immune recognition and inflammasome activation in Listeria monocytogenes infection.

Front Microbiol. 2011;1: 149

http://www.ncbi.nlm.nih.gov/pubmed/21607087

Sachs UJ, Wasel W, Bayat B, Bohle RM, Hattar K, Berghöfer H, Reil A, Bux J, Bein G, Santoso S, Weissmann N.

Mechanism of transfusion-related acute lung injury induced by HLA class II antibodies.

Blood. 2011 Jan 13;117(2):669-77. Epub 2010 Oct 28

http://www.ncbi.nlm.nih.gov/pubmed/21030555

Krüger S, Ewig S, Kunde J, Hartmann O, Marre R, Suttorp N, Welte T; CAPNETZ study group.

Assessment of inflammatory markers in patients with community-acquired pneumonia--influence of antimicrobial pre-treatment: results from the German competence network CAPNETZ.

Clin Chim Acta. 2010 Dec 14;411(23-24):1929-34. Epub 2010 Aug 7.

http://www.ncbi.nlm.nih.gov/pubmed/20699094

Krüger S, Ewig S, Giersdorf S, Hartmann O, Suttorp N, Welte T; German Competence Network for the Study of Community Acquired Pneumonia (CAPNETZ) Study Group.

Cardiovascular and inflammatory biomarkers to predict short- and long-term survival in community-acquired pneumonia: Results from the German Competence Network, CAPNETZ.

Am J Respir Crit Care Med. 2010 Dec 1;182(11):1426-34. Epub 2010 Jul 16.

http://www.ncbi.nlm.nih.gov/pubmed/20639437

Müller HC, Witzenrath M, Tschernig T, Gutbier B, Hippenstiel S, Santel A, Suttorp N, Rosseau S.

Adrenomedullin attenuates ventilator-induced lung injury in mice.

Thorax. 2010 Dec;65(12):1077-84. Epub 2010 Oct 22

http://www.ncbi.nlm.nih.gov/pubmed/20971983

Mikulski Z, Hartmann P, Jositsch G, Zaslona Z, Lips KS, Pfeil U, Kurzen H, Lohmeyer J, Clauss WG, Grau V, Fronius M, Kummer W.

Nicotinic receptors on rat alveolar macrophages dampen ATP-induced increase in cytosolic calcium concentration.

Respir Res. 2010 Sep 29;11:133. doi: 10.1186/1465-9921-11-133

http://www.ncbi.nlm.nih.gov/pubmed/20920278

Müller HC, Hellwig K, Rosseau S, Tschernig T, Schmiedl A, Gutbier B, Schmeck B, Hippenstiel S, Peters H, Morawietz L, Suttorp N, Witzenrath M.

Simvastatin attenuates ventilator-induced lung injury in mice.

Crit Care. 2010 14(4):R143. Epub 2010 Jul 30.

http://www.ncbi.nlm.nih.gov/pubmed/20673352

Lorenz J, Zahlten J, Pollok I, Lippmann J, Scharf S, N´Guessan PD, Opitz B, Flieger A, Suttorp N, Hippenstiel S, Schmeck B.

Legionella pneumophila-induced I?B?-dependent expression of interleukin-6 in lung epithelium.

Eur Respir J. 2011 Mar;37(3):648-57. Epub 2010 Jul 22.

http://www.ncbi.nlm.nih.gov/pubmed/20650996

Scharf S, Vardarova K, Lang F, Schmeck B, Opitz B, Flieger A, Heuner K, Hippenstiel S, Suttorp N, N´Guessan PD.

Legionella pneumophila induces human beta defensin-3 in pulmonary cells.

Respir Res. 2010 Jul 8;11:93.

http://www.ncbi.nlm.nih.gov/pubmed/20615218

Zahlten J, Steinicke R, Opitz B, Eitel J, N´guessan PD, Vinzing M, Witzenrath M, Schmeck B, Hammerschmidt S, Suttorp N, Hippenstiel S.

TLR2- and nucleotide-binding oligomerization domain 2-dependent Krüppel-like factor 2 expression downregulates NF-kappa B-related gene expression.

J Immunol. 2010 Jul 1;185(1):597-604. Epub 2010 Jun 4

http://www.ncbi.nlm.nih.gov/pubmed/20525885