Transregio SFB-TR 84 “Innate Immunity of the Lung: Mechanisms of Pathogen Attack and Host Defence in Pneumonia“

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Publications

Jones MR, Lingampally A, Ahmadvand N, Chong L, Wu J, Wilhem J, Vazquez-Armendariz AI, Ansari M, Herold S, Ornitz DM, Schiller HB, Chao CM, Zhang JS, Carraro G, Bellusci S.

FGFR2b signalling restricts lineage-flexible alveolar progenitors during mouse lung development and converges in mature alveolar type 2 cells.

Cell Mol Life Sci. 2022 Nov 29;79(12):609. doi: 10.1007/s00018-022-04626-2.
https://pubmed.ncbi.nlm.nih.gov/36445537/

Martin TR, Zemans RL, Ware LB, Schmidt EP, Riches DWH, Bastarache L, Calfee CS, Desai TJ, Herold S, Hough CL, Looney MR, Matthay MA, Meyer N, Parikh SM, Stevens T, Thompson BT.

New Insights into Clinical and Mechanistic Heterogeneity of the Acute Respiratory Distress Syndrome: Summary of the Aspen Lung Conference 2021.

Am J Respir Cell Mol Biol. 2022 Sep;67(3):284-308. doi: 10.1165/rcmb.2022-0089WS. 
https://pubmed.ncbi.nlm.nih.gov/35679511/

Kheirollahi V, Khadim A, Kiliaris G, Korfei M, Barroso MM, Alexopoulos I, Vazquez-Armendariz AI, Wygrecka M, Ruppert C, Guenther A, Seeger W, Herold S, El Agha E.

Transcriptional Profiling of Insulin-like Growth Factor Signaling Components in Embryonic Lung Development and Idiopathic Pulmonary Fibrosis.

Cells. 2022 Jun 20;11(12):1973. doi: 10.3390/cells11121973. https://pubmed.ncbi.nlm.nih.gov/35741102/​​​​​​​

Taghizadeh S, Chao CM, Guenther S, Glaser L, Gersmann L, Michel G, Kraut S, Goth K, Koepke J, Heiner M, Vazquez-Armendariz AI, Herold S, Samakovlis C, Weissmann N, Ricci F, Aquila G, Boyer L, Ehrhardt H, Minoo P, Bellusci S, Rivetti S.

FGF10 Triggers De Novo Alveologenesis in a Bronchopulmonary Dysplasia Model: Impact on Resident Mesenchymal Niche Cells.

Stem Cells. 2022 Jun 22;40(6):605-617. doi:10.1093/stmcls/sxac025. https://pubmed.ncbi.nlm.nih.gov/35437594/

Ahmadvand N, Lingampally A, Khosravi F, Vazquez-Armendariz AI, Rivetti S, Jones MR, Wilhelm J, Herold S, Barreto G, Koepke J, Samakovlis C, Carraro G, Zhang JS, Al Alam D, Bellusci S.

Fgfr2b signaling is essential for the maintenance of the alveolar epithelial type 2 lineage during lung homeostasis in mice.

Cell Mol Life Sci. 2022 May 19;79(6):302. doi: 10.1007/s00018-022-04327-w. https://pubmed.ncbi.nlm.nih.gov/35587837/

Vazquez-Armendariz AI, Barroso MM, El Agha E, Herold S.

3D In Vitro Models: Novel Insights into Idiopathic Pulmonary Fibrosis Pathophysiology and Drug Screening.

Cells. 2022 May 2;11(9):1526. doi: 10.3390/cells11091526. 
https://pubmed.ncbi.nlm.nih.gov/35563831/

Sauerhering L, Kuznetsova I, Kupke A, Meier L, Halwe S, Rohde C, Schmidt J, Morty RE, Danov O, Braun A, Vadász I, Becker S, Herold S.

Cyclosporin A Reveals Potent Antiviral Effects in Preclinical Models of SARS-CoV-2 Infection

Am J Respir Crit Care Med. 2022 Feb 15. doi: 10.1164/rccm.202108-1830LE. Online ahead of print. https://pubmed.ncbi.nlm.nih.gov/35167409/

Conrad C, Yildiz D, Cleary SJ, Margraf A, Cook L, Schlomann U, Panaretou B, Bowser JL, Karmouty-Quintana H, Li J, Berg NK, Martin SC, Aljohmani A, Moussavi-Harami SF, Wang KM, Tian JJ, Magnen M, Valet C, Qiu L, Singer JP, Eltzschig HK; CAPSys Study Group, Bertrams W, Herold S, Suttorp N, Schmeck B, Ball ZT, Zarbock A, Looney MR, Bartsch JW.

ADAM8 signaling drives neutrophil migration and ARDS severity

JCI Insight. 2022 Feb 8;7(3):e149870. doi: 10.1172/jci.insight.149870.  https://pubmed.ncbi.nlm.nih.gov/35132956/

Wendisch D, Dietrich O, Mari T, von Stillfried S, Ibarra IL, Mittermaier M, Mache C, Chua RL, Knoll R, Timm S, Brumhard S, Krammer T, Zauber H, Hiller AL, Pascual-Reguant A, Mothes R, Bülow RD, Schulze J, Leipold AM, Djudjaj S, Erhard F, Geffers R, Pott F, Kazmierski J, Radke J, Pergantis P, Baßler K, Conrad C, Aschenbrenner AC, Sawitzki B, Landthaler M, Wyler E, Horst D; Deutsche COVID-19 OMICS Initiative (DeCOI), Hippenstiel S, Hocke A, Heppner FL, Uhrig A, Garcia C, Machleidt F, Herold S, Elezkurtaj S, Thibeault C, Witzenrath M, Cochain C, Suttorp N, Drosten C, Goffinet C, Kurth F, Schultze JL, Radbruch H, Ochs M, Eils R, Müller-Redetzky H, Hauser AE, Luecken MD, Theis FJ, Conrad C, Wolff T, Boor P, Selbach M, Saliba AE, Sander LE.

SARS-CoV-2 infection triggers profibrotic macrophage responses and lung fibrosis.

Cell. 2021 Nov 27:S0092-8674(21)01383-0. doi: 10.1016/j.cell.2021.11.033. Epub ahead of print. PMID: 34914922. pubmed.ncbi.nlm.nih.gov/34914922/

Shaban MS, Müller C, Mayr-Buro C, Weiser H, Meier-Soelch J, Albert BV, Weber A, Linne U, Hain T, Babayev I, Karl N, Hofmann N, Becker S, Herold S, Schmitz ML, Ziebuhr J, Kracht M.

Multi-level inhibition of coronavirus replication by chemical ER stress.

Nat Commun. 2021 Sep 20;12(1):5536. doi: 10.1038/s41467-021-25551-1. PMID: 34545074; PMCID: PMC8452654. pubmed.ncbi.nlm.nih.gov/34545074/

Vazquez-Armendariz AI, Seeger W, Herold S, El Agha E.

Protocol for the generation of murine bronchiolospheres.

STAR Protoc. 2021 Jun 11;2(2):100594. doi: 10.1016/j.xpro.2021.100594. PMID: 34169288; PMCID: PMC8209683. pubmed.ncbi.nlm.nih.gov/34169288/

Vazquez-Armendariz AI, Herold S.

From Clones to Buds and Branches. The Use of Lung Organoids to Mod Branching Morphogenesis Ex Vivo

Front Cell Dev Biol. 2021 Mar 4;9:631579. doi: 10.3389/fcell.2021.631579. PMID: 33748115; PMCID: PMC7969706. pubmed.ncbi.nlm.nih.gov/33748115/

Vázquez-Armendariz AI, Heiner M, El Agha E, Salwig I, Hoek A, Rupp MC, Shalashova I, Shrestha A, Carraro G, Mengel JP, Günther A, Morty RE, Vadasz I, Schwemmle M, Kummer W, Hain T, Goesmann A, Bellusci S, Seeger W, Braun T, Herold S.

Multilineage murine stem cells generate complex organoids to model distal lung development and disease

EMBO J. 2020 Nov 2;39(21):e103476. doi: 10.15252/embj.2019103476.

Myti D, Gunjak M, Casado F, Khaghani Raziabad S, Nardiello C, Vadasz I, Herold S, Pryhuber G, Seeger W, Morty RE.

Elevated FiO 2 increases SARS-CoV-2 co-receptor expression in respiratory tract epithelium

Am J Physiol Lung Cell Mol Physiol. 2020 Oct 1;319(4):L670-L674. doi: 10.1152/ajplung.00345.2020.

Sauerhering L, Kupke A, Meier L, Dietzel E, Hoppe J, Gruber AD, Gattenloehner S, Witte B, Fink L, Hofmann N, Zimmermann T, Goesmann A, Nist A, Stiewe T, Becker S, Herold S, Peteranderl C.

Cyclophilin Inhibitors Restrict Middle East Respiratory Syndrome Coronavirus Via Interferon λ In Vitro And In Mice

Eur Respir J. 2020 Jul 2; 1901826.

Taghizadeh S, Heiner M, Vazquez-Armendariz AI, Wilhelm J, Herold S, Chen C, Zhang JS, Bellusci S.

Characterization in mice of the resident mesenchymal niche maintaining AT2 stem cell proliferation in homeostasis and disease.

Stem Cells. 2021 Oct;39(10):1382-1394. doi: 10.1002/stem.3423. Epub 2021 Jun 15. PMID: 34048616. pubmed.ncbi.nlm.nih.gov/34048616/