Erfinanda L, Zou L, Gutbier B, Kneller L, Weidenfeld S, Michalick L, Lei D, Reppe K, Teixeira Alves LG, Schneider B, Zhang Q, Li C, Fatykhova D, Schneider P, Liedtke W, Sohara E, Mitchell TJ, Gruber AD, Hocke A, Hippenstiel S, Suttorp N, Olschewski A, Mall MA, Witzenrath M, Kuebler WM

Loss of endothelial CFTR drives barrier failure and edema formation in lung infection and can be targeted by CFTR potentiation

Sci Transl Med. 2022 Dec 7;14(674):eabg8577.
doi: 10.1126/scitranslmed.abg8577. https://pubmed.ncbi.nlm.nih.gov/36475904/

Banovic F, Schulze S, Abu Mraheil M, Hain T, Chakraborty T, Orian-Rousseau V, Moroniak S, Weiss C, Ishikawa H, Schroten H, Adam R, Schwerk C.

Different Involvement of Vimentin during Invasion by Listeria monocytogenes at the Blood-Brain and the Blood-Cerebrospinal Fluid Barriers In Vitro

Int J Mol Sci 2022 Oct 26;23(21):12908. 
doi: 10.3390/ijms232112908. https://pubmed.ncbi.nlm.nih.gov/36361697/

Niemeyer D, Stenzel S, Veith T, Schroeder S, Friedmann K, Weege F, Trimpert J, Heinze J, Richter A, Jansen J, Emanuel J, Kazmierski J, Pott F, Jeworowski LM, Olmer R, Jaboreck MC, Tenner B, Papies J, Walper F, Schmidt ML, Heinemann N, Möncke-Buchner E, Baumgardt M, Hoffmann K, Widera M, Thao TTN, Balázs A, Schulze J, Mache C, Jones TC, Morkel M, Ciesek S, Hanitsch LG, Mall MA, Hocke AC, Thiel V, Osterrieder K, Wolff T, Martin U, Corman VM, Müller MA, Goffinet C, Drosten C.

SARS-CoV-2 variant Alpha has a spike-dependent replication advantage over the ancestral B.1 strain in human cells with low ACE2 expression

PLoS Biol. 2022 Nov 16;20(11):e3001871. https://pubmed.ncbi.nlm.nih.gov/36383605/

Wagner C, Balazs A, Schatterny J, Zhou-Suckow Z, Duerr J, Schultz C, Mall MA.

Genetic Deletion of Mmp9 Does Not Reduce Airway Inflammation and Structural Lung Damage in Mice with Cystic Fibrosis-like Lung Disease.

Int J Mol Sci. 2022 Nov 2;23(21):13405. doi: 10.3390/ijms232113405. https://pubmed.ncbi.nlm.nih.gov/36362203/

Margaroli C, Horati H, Garratt LW, Giacalone VD, Schofield C, Dittrich AS, Rosenow T, Dobosh BS, Lim HS, Frey DL, Veltman M, Silva GL, Brown MR, Schultz C, Tiddens HAWM, Ranganathan S, Chandler JD, Qiu P, Peng L, Scholte BJ, Mall MA, Kicic A, Guglani L, Stick SM, Janssens HM, Tirouvanziam R.

Macrophage PD-1 associates with neutrophilia and reduced bacterial killing in early cystic fibrosis airway disease

J Cyst Fibros. 2022 Jun 19;S1569-1993(22)00588-4. doi: 10.1016/j.jcf.2022.06.001. https://pubmed.ncbi.nlm.nih.gov/35732550/

Frey DL, Bridson C, Dittrich S, Graeber SY, Stahl M, Wege S, Herth F, Sommerburg O, Schultz C, Dalpke A, Mall MA, Boutin S.

Changes in Microbiome Dominance Are Associated With Declining Lung Function and Fluctuating Inflammation in People With Cystic Fibrosis

Front Microbiol. 2022 May 13;13:885822. doi: 10.3389/fmicb.2022.885822. eCollection 2022. https://pubmed.ncbi.nlm.nih.gov/35633718/

Loske J, Röhmel J, Lukassen S, Stricker S, Magalhães VG, Liebig J, Chua RL, Thürmann L, Messingschlager M, Seegebarth A, Timmermann B, Klages S, Ralser M, Sawitzki B, Sander LE, Corman VM, Conrad C, Laudi S, Binder M, Trump S, Eils R, Mall MA, Lehmann I.

Pre-activated antiviral innate immunity in the upper airways controls early SARS-CoV-2 infection in children

Nat Biotechnol. 2022 Mar;40(3):319-324. doi: 10.1038/s41587-021-01037-9. Epub 2021 Aug 18.  https://pubmed.ncbi.nlm.nih.gov/34408314/

Zhu L, Duerr J, Zhou-Suckow Z, Wagner W, Weinheimer O, Salomon J, Leitz D, Konietzke P, Yu H, Ackermann M, Stiller W, Kauczor HU, Mall MA, Wielpütz MO.

µCT to quantify muco-obstructive lung disease and effects of neutrophil elastase knockout in mice

Am J Physiol Lung Cell Mol Physiol. 2022 Mar 1;322(3):L401-L411. doi: 10.1152/ajplung.00341.2021. Epub 2022 Jan 26. https://pubmed.ncbi.nlm.nih.gov/35080183/

Georg P, Astaburuaga-García R, Bonaguro L, Brumhard S, Michalick L, Lippert LJ, Kostevc T, Gäbel C, Schneider M, Streitz M, Demichev V, Gemünd I, Barone M, Tober-Lau P, Helbig ET, Hillus D, Petrov L, Stein J, Dey HP, Paclik D, Iwert C, Mülleder M, Aulakh SK, Djudjaj S, Bülow RD, Mei HE, Schulz AR, Thiel A, Hippenstiel S, Saliba AE, Eils R, Lehmann I, Mall MA, Stricker S, Röhmel J, Corman VM, Beule D, Wyler E, Landthaler M, Obermayer B, von Stillfried S, Boor P, Demir M, Wesselmann H, Suttorp N, Uhrig A, Müller-Redetzky H, Nattermann J, Kuebler WM, Meisel C, Ralser M, Schultze JL, Aschenbrenner AC, Thibeault C, Kurth F, Sander LE, Blüthgen N, Sawitzki B; PA-COVID-19 Study Group.

Complement activation induces excessive T cell cytotoxicity in severe COVID-19

Cell. 2022 Feb 3;185(3):493-512.e25.  doi: 10.1016/j.cell.2021.12.040.  Epub 2021 Dec 28. pubmed.ncbi.nlm.nih.gov/35032429/

Metzger MI, Graeber SY, Stahl M, Sommerburg O, Mall MA, Dalpke AH, Boutin S.

A Volatile and Dynamic Longitudinal Microbiome Is Associated With Less Reduction in Lung Function in Adolescents With Cystic Fibrosis

Front Cell Infect Microbiol. 2021 Dec 6;11:763121. doi: 10.3389/fcimb.2021.763121. eCollection 2021. https://pubmed.ncbi.nlm.nih.gov/34938669/

Mahmoud W, Perniss A, Poharkar K, Soultanova A, Pfeil U, Hoek A, Bhushan S, Hain T, Gärtner U, Kummer W.

CXCL13 is expressed in a subpopulation of neuroendocrine cells in the murine trachea and lung.

Cell Tissue Res. 2022 Oct;390(1):35-49. doi: 10.1007/s00441-021-03552-2. pubmed.ncbi.nlm.nih.gov/34762185/

Hey J, Paulsen M, Toth R, Weichenhan D, Butz S, Schatterny J, Liebers R, Lutsik P, Plass C, Mall MA.

Epigenetic reprogramming of airway macrophages promotes polarization and inflammation in muco-obstructive lung disease

Nat Commun. 2021 Nov 11;12(1):6520.  doi: 10.1038/s41467-021-26777-9. pubmed.ncbi.nlm.nih.gov/34764283/

Witkowski M, Tizian C, Ferreira-Gomes M, Niemeyer D, Jones TC, Heinrich F, Frischbutter S, Angermair S, Hohnstein T, Mattiola I, Nawrath P, Mc Ewen S, Zocche S, Viviano E, Heinz GA, Maurer M, Kölsch U, Chua RL, Aschman T, Meisel C, Radke J, Sawitzki B, Roehmel J, Allers K, Moos V, Schneider T, Hanitsch L, Mall MA, Conrad C, Radbruch H, Duerr CU, Trapani JA, Marcenaro E, Kallinich T, Corman VM, Kurth F, Sander LE, Drosten C, Treskatsch S, Durek P, Kruglov A, Radbruch A, Mashreghi MF, Diefenbach A.

Untimely TGFβ responses in COVID-19 limit antiviral functions of NK cells

Nature. 2021 Oct 25. doi: 10.1038/s41586-021-04142-6. Epub ahead of print. PMID: 34695836. pubmed.ncbi.nlm.nih.gov/34695836/

Loyal L, Braun J, Henze L, Kruse B, Dingeldey M, Reimer U, Kern F, Schwarz T, Mangold M, Unger C, Dörfler F, Kadler S, Rosowski J, Gürcan K, Uyar-Aydin Z, Frentsch M, Kurth F, Schnatbaum K, Eckey M, Hippenstiel S, Hocke A, Müller MA, Sawitzki B, Miltenyi S, Paul F, Mall MA, Wenschuh H, Voigt S, Drosten C, Lauster R, Lachman N, Sander LE, Corman VM, Röhmel J, Meyer-Arndt L, Thiel A, Giesecke-Thiel C.

Cross-reactive CD4+ T cells enhance SARS-CoV-2 immune responses upon infection and vaccination.

Science. 2021 Aug 31:eabh1823. doi: 10.1126/science.abh1823. Epub ahead of print. PMID: 34465633. pubmed.ncbi.nlm.nih.gov/34465633/

Engelmann TA, Knudsen L, Leitz DHW, Duerr J, Beers MF, Mall MA, Ochs M.

Linking Fibrotic Remodeling and Ultrastructural Alterations of Alveolar Epithelial Cells after Deletion of Nedd4-2.

Int J Mol Sci. 2021 Jul 16;22(14):7607. doi: 10.3390/ijms22147607. PMID: 34299227; PMCID: PMC8306112. pubmed.ncbi.nlm.nih.gov/34299227/

Leitz DHW, Duerr J, Mulugeta S, Seyhan Agircan A, Zimmermann S, Kawabe H, Dalpke AH, Beers MF, Mall MA.

Congenital Deletion of Nedd4-2 in Lung Epithelial Cells Causes Progressive Alveolitis and Pulmonary Fibrosis in Neonatal Mice.

Int J Mol Sci. 2021 Jun 7;22(11):6146. doi: 10.3390/ijms22116146. PMID: 34200296; PMCID: PMC8201155. pubmed.ncbi.nlm.nih.gov/34200296/

Hagner M, Albrecht M, Guerra M, Braubach P, Halle O, Zhou-Suckow Z, Butz S, Jonigk D, Hansen G, Schultz C, Dittrich AM, Mall MA.

IL-17A from innate and adaptive lymphocytes contributes to inflammation and damage in cystic fibrosis lung disease

Eur Respir J. 2021 Jun 4;57(6):1900716. doi: 10.1183/13993003.00716-2019. PMID: 33303549. pubmed.ncbi.nlm.nih.gov/33303549/

McKelvey MC, Brown R, Ryan S, Mall MA, Weldon S, Taggart CC.

Proteases, Mucus, and Mucosal Immunity in Chronic Lung Disease

Int J Mol Sci. 2021 May 9;22(9):5018. doi: 10.3390/ijms22095018. PMID: 34065111; PMCID: PMC8125985. pubmed.ncbi.nlm.nih.gov/34065111/

Brown R, Small DM, Doherty DF, Holsinger L, Booth R, Williams R, Ingram RJ, Elborn JS, Mall MA, Taggart CC, Weldon S.

Therapeutic Inhibition of Cathepsin S Reduces Inflammation and Mucus Plugging in Adult βENaC-Tg Mice.

Mediators Inflamm. 2021 Mar 19;2021:6682657. doi: 10.1155/2021/6682657. PMID: 33828414; PMCID: PMC8004367.

pubmed.ncbi.nlm.nih.gov/33828414/

Frey DL, Boutin S, Dittrich SA, Graeber SY, Stahl M, Wege S, Herth FJF, Sommerburg O, Schultz C, Mall MA, Dalpke AH.

Relationship between airway dysbiosis, inflammation and lung function in adults with cystic fibrosis

J Cyst Fibros. 2021 Jan 8:S1569-1993(20)30954-1. doi: 10.1016/j.jcf.2020.12.022. Epub ahead of print. PMID: 33431308. pubmed.ncbi.nlm.nih.gov/33431308/

Hahn L, Helmrich N, Herebian D, Mayatepek E, Drebber U, Domann E, Olejniczak S, Weigel M, Hain T, Rath T, Wirtz S, Mollenkopf HJ, Schmidt N, Ewers C, Churin Y, Windhorst A, Weiskirchen R, Steinhoff U, Roeb E, Roderfeld M.

IL-13 as target to reduce cholestasis and dysbiosis in Abcb4 knockout mice.

Cells, 9:E1949 2020.

Vega G, Guequén A, Philp AR, Gianotti A, Arzola L, Villalón M, Zegarra-Moran O, Galietta LJ, Mall MA, Flores CA.

Lack of Kcnn4 improves mucociliary clearance in muco-obstructive lung disease.

JCI Insight. 2020 Aug 20;5(16):e140076. doi: 10.1172/jci.insight.140076.

Duerr J, Leitz DHW, Szczygiel M, Dvornikov D, Fraumann SG Kreutz C, Zadora PK, Seyhan Agircan A Konietzke P, Engelmann TA, Hegermann J, Mulugeta S, Kawabe H, Knudsen L, Ochs M, Rotin D, Muley T, Kreuter M, Herth FJF, Wielpütz MO, Beers MF, Klingmüller U, Mall MA

Conditional deletion of Nedd4-2 in lung epithelial cells causes progressive pulmonary fibrosis in adult mice.

Nat Commun. 2020 Apr 24;11(1):2012

Brown R, Paulsen M, Schmidt S, Schatterny J, Frank A, Hirtz S, Delaney R, Doherty D, Hagner M, Taggart C, Weldon S, Mall MA

Lack of IL-1 receptor signaling reduces spontaneous airway eosinophilia in juvenile mice with muco-obstructive lung disease.

Am J Respir Cell Mol Biol. 2020 Mar;62(3):300-309.

Hagner M, Frey DL, Guerra M, Dittrich AS, Halls VS, Wege S, Herth FJF, Schultz C, Mall MA

New method for rapid and dynamic quantification of elastase activity on sputum neutrophils from patients with cystic fibrosis using flow cytometry.

Eur Respir J. 2020 Mar 5. pii: 1902355

McKelvey MC, Weldon S, McAuley DF, Mall MA, Taggart CC

Targeting proteases in cystic fibrosis lung disease: Paradigms, progress, and potential.

Am J Respir Crit Care Med. 2020 Jan 15;201(2):141-147.

Mall MA, Mayer-Hamblett N, Rowe SM

Cystic fibrosis: Emergence of highly effective targeted therapeutics and potential clinical implications.

Am J Respir Crit Care Med. 2019 Dec 20

Balazs A, Mall MA

Mucus obstruction and inflammation in early cystic fibrosis lung disease: Emerging role of the IL-1 signaling pathway.

Pediatr Pulmonol. 2019 Nov;54 Suppl 3:S5-S12.

Frantz R, Teubner L, Schultze T, La Pietra L, Müller C, Gwozdzinski K, Pillich H, Hain T, Weber-Gerlach M, Panagiotidis GD, Mostafa A, Weber F, Rohde M, Pleschka S, Chakraborty T, Abu Mraheil M.

The secRNome of Listeria monocytogenes Harbors Small Noncoding RNAs That Are Potent Inducers of Beta Interferon.

mBio. 2019. 10(5):e01223-19.

Heß N, Waldow F, Kohler TP, Rohde M, Kreikemeyer B, Gómez-Mejia A, Hain T, Schwudke D, Vollmer W, Hammerschmidt S, Gisch N

LTA deficiency permits normal growth but impairs virulence of Streptococcus pneumoniae.

Nat Commun. 2017 Dec 12;8(1):2093

https://www.ncbi.nlm.nih.gov/pubmed/29233962