Transregio SFB-TR 84 “Innate Immunity of the Lung: Mechanisms of Pathogen Attack and Host Defence in Pneumonia“

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Publications

Leitz DHW, Duerr J, Mulugeta S, Seyhan Agircan A, Zimmermann S, Kawabe H, Dalpke AH, Beers MF, Mall MA.

Congenital Deletion of Nedd4-2 in Lung Epithelial Cells Causes Progressive Alveolitis and Pulmonary Fibrosis in Neonatal Mice.

Int J Mol Sci. 2021 Jun 7;22(11):6146. doi: 10.3390/ijms22116146. PMID: 34200296; PMCID: PMC8201155. pubmed.ncbi.nlm.nih.gov/34200296/

Hagner M, Albrecht M, Guerra M, Braubach P, Halle O, Zhou-Suckow Z, Butz S, Jonigk D, Hansen G, Schultz C, Dittrich AM, Mall MA.

IL-17A from innate and adaptive lymphocytes contributes to inflammation and damage in cystic fibrosis lung disease

Eur Respir J. 2021 Jun 4;57(6):1900716. doi: 10.1183/13993003.00716-2019. PMID: 33303549. pubmed.ncbi.nlm.nih.gov/33303549/

McKelvey MC, Brown R, Ryan S, Mall MA, Weldon S, Taggart CC.

Proteases, Mucus, and Mucosal Immunity in Chronic Lung Disease

Int J Mol Sci. 2021 May 9;22(9):5018. doi: 10.3390/ijms22095018. PMID: 34065111; PMCID: PMC8125985. pubmed.ncbi.nlm.nih.gov/34065111/

Brown R, Small DM, Doherty DF, Holsinger L, Booth R, Williams R, Ingram RJ, Elborn JS, Mall MA, Taggart CC, Weldon S.

Therapeutic Inhibition of Cathepsin S Reduces Inflammation and Mucus Plugging in Adult βENaC-Tg Mice.

Mediators Inflamm. 2021 Mar 19;2021:6682657. doi: 10.1155/2021/6682657. PMID: 33828414; PMCID: PMC8004367.

pubmed.ncbi.nlm.nih.gov/33828414/

Frey DL, Boutin S, Dittrich SA, Graeber SY, Stahl M, Wege S, Herth FJF, Sommerburg O, Schultz C, Mall MA, Dalpke AH.

Relationship between airway dysbiosis, inflammation and lung function in adults with cystic fibrosis

J Cyst Fibros. 2021 Jan 8:S1569-1993(20)30954-1. doi: 10.1016/j.jcf.2020.12.022. Epub ahead of print. PMID: 33431308. pubmed.ncbi.nlm.nih.gov/33431308/

Hahn L, Helmrich N, Herebian D, Mayatepek E, Drebber U, Domann E, Olejniczak S, Weigel M, Hain T, Rath T, Wirtz S, Mollenkopf HJ, Schmidt N, Ewers C, Churin Y, Windhorst A, Weiskirchen R, Steinhoff U, Roeb E, Roderfeld M.

IL-13 as target to reduce cholestasis and dysbiosis in Abcb4 knockout mice.

Cells, 9:E1949 2020.

Vega G, Guequén A, Philp AR, Gianotti A, Arzola L, Villalón M, Zegarra-Moran O, Galietta LJ, Mall MA, Flores CA.

Lack of Kcnn4 improves mucociliary clearance in muco-obstructive lung disease.

JCI Insight. 2020 Aug 20;5(16):e140076. doi: 10.1172/jci.insight.140076.

Kurth F, Roennefarth M, Thibeault C, Corman VM, Müller-Redetzky H, Mittermaier M, Ruwwe-Glösenkamp C, Heim KM, Krannich A, Zvorc S, Schmidt S, Kretzler L, Dang-Heine C, Rose M, Hummel M, Hocke A, Hübner RH, Opitz B, Mall MA, Röhmel J, Landmesser U, Pieske B, Knauss S, Endres M, Spranger J, Mockenhaupt FP, Tacke F, Treskatsch S, Angermair S, Siegmund B, Spies C, Weber-Carstens S, Eckardt KU, Schürmann D, Uhrig A, Stegemann MS, Zoller T, Drosten C, Suttorp N, Witzenrath M, Hippenstiel S, von Kalle C, Sander LE.

Studying the pathophysiology of coronavirus disease 2019: a protocol for the Berlin prospective COVID-19 patient cohort (Pa-COVID-19).

Infection. 2020 Aug;48(4):619-626.

Duerr J, Leitz DHW, Szczygiel M, Dvornikov D, Fraumann SG Kreutz C, Zadora PK, Seyhan Agircan A Konietzke P, Engelmann TA, Hegermann J, Mulugeta S, Kawabe H, Knudsen L, Ochs M, Rotin D, Muley T, Kreuter M, Herth FJF, Wielpütz MO, Beers MF, Klingmüller U, Mall MA

Conditional deletion of Nedd4-2 in lung epithelial cells causes progressive pulmonary fibrosis in adult mice.

Nat Commun. 2020 Apr 24;11(1):2012

Brown R, Paulsen M, Schmidt S, Schatterny J, Frank A, Hirtz S, Delaney R, Doherty D, Hagner M, Taggart C, Weldon S, Mall MA

Lack of IL-1 receptor signaling reduces spontaneous airway eosinophilia in juvenile mice with muco-obstructive lung disease.

Am J Respir Cell Mol Biol. 2020 Mar;62(3):300-309.

Hagner M, Frey DL, Guerra M, Dittrich AS, Halls VS, Wege S, Herth FJF, Schultz C, Mall MA

New method for rapid and dynamic quantification of elastase activity on sputum neutrophils from patients with cystic fibrosis using flow cytometry.

Eur Respir J. 2020 Mar 5. pii: 1902355

McKelvey MC, Weldon S, McAuley DF, Mall MA, Taggart CC

Targeting proteases in cystic fibrosis lung disease: Paradigms, progress, and potential.

Am J Respir Crit Care Med. 2020 Jan 15;201(2):141-147.

Bell SC, Mall MA, Gutierrez H, Macek M, Madge S, Davies JC, Burgel PR, Tullis E, Castanos C, Castellani C, Byrnes CA, Cathcart F, Chotirmall SH, Cosgriff R, Eichler I, Fajac I, Goss CH, Drevinek P, Farrell PM, Gravelle AM, Havermans T, Mayer-Hamblett N, Kashirskaya N, Kerem E, Mathew JL, McKone EF, Naehrlich L, Nasr SZ, Oates GR, O'Neill C, Pypops U, Raraigh KS, Rowe SM, Southern KW, Sivam S, Stephenson AL, Zampoli M, Ratjen F

The future of cystic fibrosis care: A global perspective.

Lancet Respir Med. 2020 Jan;8(1):65-124.

Mall MA, Mayer-Hamblett N, Rowe SM

Cystic fibrosis: Emergence of highly effective targeted therapeutics and potential clinical implications.

Am J Respir Crit Care Med. 2019 Dec 20

Balazs A, Mall MA

Mucus obstruction and inflammation in early cystic fibrosis lung disease: Emerging role of the IL-1 signaling pathway.

Pediatr Pulmonol. 2019 Nov;54 Suppl 3:S5-S12.

 

Frantz R, Teubner L, Schultze T, La Pietra L, Müller C, Gwozdzinski K, Pillich H, Hain T, Weber-Gerlach M, Panagiotidis GD, Mostafa A, Weber F, Rohde M, Pleschka S, Chakraborty T, Abu Mraheil M.

The secRNome of Listeria monocytogenes Harbors Small Noncoding RNAs That Are Potent Inducers of Beta Interferon.

mBio. 2019. 10(5):e01223-19.

Dittrich AS, Kühbandner I, Gehrig S, Rickert-Zacharias V, Twigg M, Wege S, Taggart CC, Herth F, Schultz C, Mall MA

Elastase activity on sputum neutrophils correlates with severity of lung disease in cystic fibrosis.

Eur Respir J. 2018 Mar 29;51(3). pii: 1701910

https://www.ncbi.nlm.nih.gov/pubmed/29545279

Boutin S, Depner M, Stahl M, Graeber SY, Dittrich SA, Legatzki A, von Mutius E, Mall M, Dalpke AH

Comparison of Oropharyngeal Microbiota from Children with Asthma and Cystic Fibrosis.

Mediators Inflamm. 2017;2017:5047403

https://www.ncbi.nlm.nih.gov/pubmed/29445257

Heß N, Waldow F, Kohler TP, Rohde M, Kreikemeyer B, Gómez-Mejia A, Hain T, Schwudke D, Vollmer W, Hammerschmidt S, Gisch N

LTA deficiency permits normal growth but impairs virulence of Streptococcus pneumoniae.

Nat Commun. 2017 Dec 12;8(1):2093

https://www.ncbi.nlm.nih.gov/pubmed/29233962

Boutin S, Graeber SY, Stahl M, Dittrich AS, Mall MA, Dalpke AH

Chronic but not intermittent infection with Pseudomonas aeruginosa is associated with global changes of the lung microbiome in cystic fibrosis.

Eur Respir J. 2017 Oct 5;50(4)

https://www.ncbi.nlm.nih.gov/pubmed/28982777