Transregio SFB-TR 84 “Innate Immunity of the Lung: Mechanisms of Pathogen Attack and Host Defence in Pneumonia“

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Bertrams W, Griss K, Han M, Seidel K, Hippenstiel S, Suttorp N, Finkernagel F, Wilhelm J, Vogelmeier CF, Schmeck B.

Transcriptional analysis identifies potential biomarkers and molecular regulators in acute malaria infection

Life Sci. 2021 Apr 1;270:119158. doi: 10.1016/j.lfs.2021.119158. Epub 2021 Feb 2. PMID: 33545200. pubmed.ncbi.nlm.nih.gov/33545200/

Ochs M, Timm S, Elezkurtaj S, Horst D, Meinhardt J, Heppner FL, Weber-Carstens S, Hocke AC, Witzenrath M.

Collapse induration of alveoli is an ultrastructural finding in a COVID-19 patient

Eur Respir J. 2021 Jan 14:2004165. doi: 10.1183/13993003.04165-2020. Epub ahead of print. PMID: 33446606; PMCID: PMC7815985. pubmed.ncbi.nlm.nih.gov/33446606/

Linzner N, Loi VV, Fritsch VN, Antelmann H.

Thiol-based redox switches in the major pathogen Staphylococcus aureus.

Biol Chemistry 2020 Dec 1.

Fritsch VN, Loi VV, Busche T, Tung QN, Lill R, Horvatek P, Wolz C, Kalinowski J, Antelmann H.

Fritsch VN, Loi VV, Busche T, Tung QN, Lill R, Horvatek P, Wolz C, Kalinowski J, Antelmann H.

Free Radic Biol Med. 2020 Dec;161:351-364. doi: 10.1016/j.freeradbiomed.2020.10.322.

Michalick L, Weidenfeld S, Grimmer B, Fatykhova D, Solymosi PD, Behrens F, Dohmen M, Brack MC, Schulz S, Thomasch E, Simmons S, Müller-Redetzky H, Suttorp N, Kurth F, Neudecker J, Toennies M, Bauer TT, Eggeling S, Corman VM, Hocke AC, Witzenrath M, Hippenstiel S, Kuebler WM.

Plasma mediators in patients with severe COVID-19 cause lung endothelial barrier failure

Eur Respir J. 2020 Nov 5;2002384. doi: 10.1183/13993003.02384-2020. Online ahead of print.

Nerlich A, von Wunsch Teruel I, Mieth M, Hönzke K, Rückert JC, Mitchell TJ, Suttorp N, Hippenstiel S, Hocke AC.

Reversion of pneumolysin induced executioner caspase activation redirects cells to survival

J Infect Dis. 2020 Oct 12;jiaa639. doi: 10.1093/infdis/jiaa639.

Linzner N, Fritsch VN, Busche T, Tung QN, Loi VV, Bernhardt J, Kalinowski J, Antelmann H.

The plant-derived naphthoquinone lapachol causes an oxidative stress response in Staphylococcus aureus

Free Radic Biol Med. 2020 Oct;158:126-136. doi: 10.1016/j.freeradbiomed.2020.07.025.

Kreye J, Reincke SM, Kornau HC, Sanchez-Sendin E, Corman VM, Liu H, Yuan M, Wu NC, Zhu X, Lee CD, Trimpert J, Hoeltje M, Dietert K, Stoeffler L, von Wardenburg N, van Hoof S, Homeyer MA, Hoffmann J, Abdelgawad A, Gruber AD, Bertzbach LD, Vladimirova D, Li LY, Barthel PC, Skriner K, Hocke AC, Hippenstiel S, Witzenrath M, Suttorp N, Kurth F, Franke C, Endres M, Schmitz D, Jeworowski LM, Richter A, Schmidt ML, Schwarz T, Mueller MA, Drosten C, Wendisch D, Sander LE, Osterrieder N, Wilson IA, Pruess H.

A therapeutic non-self-reactive SARS-CoV-2 antibody protects from lung pathology in a COVID-19 hamster model.

CELL 11649

Schulte-Schrepping J, Reusch N, Paclik D, Baßler K, Schlickeiser S, Zhang B, Krämer B, Krammer T, Brumhard S, Bonaguro L, De Domenico E, Wendisch D, Grasshoff M, Kapellos TS, Beckstette M, Pecht T, Saglam A, Dietrich O, Mei HE, Schulz AR, Conrad C, Kunkel D, Vafadarnejad E, Xu C-J, Horne A, Herbert M, Drews A, Thibeault C, Pfeiffer M, Hippenstiel S, Hocke A, Müller-Redetzky H, Heim K-M, Machleidt F, Uhrig A, Bosquillon de Jarcy L, Jürgens L, Stegemann M, Glösenkamp CR, Volk H-D, Goffinet C, Landthaler M, Wyler E, Georg P, Schneider M, Dang-Heine C, Neuwinger N, Kappert K, Tauber R, Corman V, Raabe J, Kaiser KM, To Vinh M, Rieke G, Meisel C, Ulas T, Becker M, Geffers R, Witzenrath M, Drosten C, Suttorp N, von Kalle C, Kurth F, Händler K, Schultze JL, Aschenbrenner AC, Li Y, Nattermann J, Sawitzki B, Saliba A-E, Sander LE

Severe COVID-19 is marked by a dysregulated myeloid cell compartment

Cell. 2020 Aug 5;S0092-8674(20)30992-2

Braun J , Loyal L, Frentsch M, Wendisch D , Georg P , Kurth F , Hippenstiel S, Dingeldey M, Kruse B, Fauchere F, Baysal E, Mangold M, Henze L, Lauster R, Mall MA, Beyer K, Röhmel J, Voigt S, Schmitz J, Miltenyi S, Demuth I, Müller MA, Hocke A, Witzenrath M, Suttorp N, Kern F, Reimer U, Wenschuh H, Drosten C, Corman VM, Giesecke-Thiel C, Sander LE, Thiel A

SARS-CoV-2-reactive T cells in healthy donors and patients with COVID-19

Nature. 2020 Jul 29. doi: 10.1038/s41586-020-2598-9

Messner CB, Demichev V, Wendisch D, Michalick L, White M, Freiwald A, Textoris-Taube K, Vernardis SI, Egger AS, Kreidl M, Ludwig D, Kilian C, Agostini F, Zelezniak A, Thibeault C, Pfeiffer M, Hippenstiel S, Hocke A, von Kalle C, Campbell A, Hayward C, Porteous DJ, Marioni RE, Langenberg C, Lilley KS, Kuebler WM, Mülleder M, Drosten C, Suttorp N, Witzenrath M, Kurth F, Sander LE, Ralser M

Ultra-High-Throughput Clinical Proteomics Reveals Classifiers of COVID-19 Infection

Cell Syst. 2020 Jul 22;11(1):11-24.e4.

Lorenz Chua R, Lukassen Soeren, Trump S, Hennig BP, Wendisch D, Pott F, Debnath O, Thürmann L, Kurth F, Völker MT, Kazmierski Julia, Timmermann B, Twardziok S, Schneider S, Machleidt F, Müller-Redetzky H , Maier M, Krannich A, Schmidt S, Balzer F, Liebig J, Loske J, Suttorp N, Eils J, Ishaque N, Liebert UG, von Kalle C, Hocke A, Witzenrath M, Goffinet C, Drosten C, Laudi S, Lehmann I, Conrad C, Sander LE, Eils R

COVID-19 severity correlates with airway epithelium-immune cell interactions identified by single-cell analysis

Nat Biotechnol. 2020 Aug;38(8):970-979

Kurth F, Roennefarth M, Thibeault C, Corman VM, Müller-Redetzky H, Mittermaier M, Ruwwe-Glösenkamp C, Heim KM, Krannich A, Zvorc S, Schmidt S, Kretzler L, Dang-Heine C, Rose M, Hummel M, Hocke A, Hübner RH, Opitz B, Mall MA, Röhmel J, Landmesser U, Pieske B, Knauss S, Endres M, Spranger J, Mockenhaupt FP, Tacke F, Treskatsch S, Angermair S, Siegmund B, Spies C, Weber-Carstens S, Eckardt KU, Schürmann D, Uhrig A, Stegemann MS, Zoller T, Drosten C, Suttorp N, Witzenrath M, Hippenstiel S, von Kalle C, Sander LE.

Studying the pathophysiology of coronavirus disease 2019: a protocol for the Berlin prospective COVID-19 patient cohort (Pa-COVID-19).

Infection. 2020 Aug;48(4):619-626.

Van Loi V, Antelmann H.

Method for measurement of bacillithiol redox potential changes using the Brx-roGFP2 redox biosensor in Staphylococcus aureus

MethodsX. 2020 Apr 24;7:100900. doi: 10.1016/j.mex.2020.100900.

Lauster D, Klenk S, Ludwig K, Nojoumi S, Behren S, Adam L, Stadtmüller M, Saenger S, Zimmler S, Hönzke K, Yao L, Hoffmann U, Bardua M, Hamann A, Witzenrath M, Sander LE, Wolff T, Hocke AC, Hippenstiel S, De Carlo S, Neudecker J, Osterrieder K, Budisa N, Netz RR, Böttcher C, Liese S, Herrmann A, Hackenberger CPR

Phage capsid nanoparticles with defined ligand arrangement block influenza virus entry

Nat Nanotechnol. 2020 May;15(5):373-379

Rohilla S, Krämer B, Koberling F, Gregor I, Hocke AC.

Multi-target immunofluorescence by separation of antibody cross-labelling via spectral-FLIM-FRET

Sci Rep. 2020 Mar 2;10(1):3820

Matos ADR, Wunderlich K, Schloer S, Schughart K, Geffers R, Seders M, Witt M, Christersson A, Wiewrodt R, Wiebe K, Barth P, Hocke A, Hippenstiel S, Hönzke K, Dittmer U, Sutter K, Rescher U, Rodionycheva S, Matera N, Ludwig S, Brunotte L.

Antiviral potential of human IFN-α subtypes against influenza A H3N2 infection in human lung explants reveals subtype-specific activities

Emerg Microbes Infect. 2019; 8(1): 1763–1776.

Fritsch VN, Loi VV, Busche T, Sommer A, Tedin K, Nürnberg DJ, Kalinowski J, Bernhardt J, Fulde M, Antelmann H

The MarR-Type Repressor MhqR Confers Quinone and Antimicrobial Resistance in Staphylococcus aureus

Antioxid Redox Signal. 2019 Dec 1;31(16):1235-1252. doi: 10.1089/ars.2019.7750.

Loi VV, Huyen NTT, Busche T, Tung QN, Gruhlke MCH, Kalinowski J, Bernhardt J, Slusarenko AJ, Antelmann H.

Staphylococcus aureus responds to allicin by global S-thioallylation - Role of the Brx/BSH/YpdA pathway and the disulfide reductase MerA to overcome allicin stress

Free Radic Biol Med. 2019 Aug 1;139:55-69. doi: 10.1016/j.freeradbiomed.2019.05.018.

Linzner N, Loi VV, Fritsch VN, Tung QN, Stenzel S, Wirtz M, Hell R, Hamilton C, Tedin K, Fulde M, Antelmann H.

Staphylococcus aureus Uses the Bacilliredoxin (BrxAB)/Bacillithiol Disulfide Reductase (YpdA) Redox Pathway to Defend Against Oxidative Stress Under Infections

Front Microbiol. 2019 Jun 18;10:1355. doi: 10.3389/fmicb.2019.01355.

Tung QN, Loi VV, Busche T, Nerlich A, Mieth M, Milse J, Kalinowski J, Hocke AC, Antelmann H.

Stable integration of the Mrx1-roGFP2 biosensor to monitor dynamic changes of the mycothiol redox potential in Corynebacterium glutamicum

Redox Biol. 2019 Jan;20:514-525

Grund C, Hoffmann D, Ulrich R, Naguib M, Schinköthe J, Hoffmann B, Harder T, Saenger S, Zscheppang K, Tönnies M, Hippenstiel S, Hocke A, Wolff T, Beer M.

A novel European H5N8 influenza A virus has increased virulence in ducks but low zoonotic potential

Emerg Microbes Infect. 2018 Jul 19;7(1):132.

Herta T, Bhattacharyya A, Bollensdorf C, Kabus C, García P, Suttorp N, Hippenstiel S, Zahlten J

DNA-release by Streptococcus pneumoniae autolysin LytA induced Krueppel-like factor 4 expression in macrophages.

Sci Rep. 2018 Apr 10;8(1):5723

https://www.ncbi.nlm.nih.gov/pubmed/29636524

Tung QN, Linzner N, Loi VV, Antelmann H

Application of genetically encoded redox biosensors to measure dynamic changes in the glutathione, bacillithiol and mycothiol redox potentials in pathogenic bacteria.

Free Radic Biol Med. 2018 Feb 15. pii: S0891-5849(18)30073-X.

https://www.sciencedirect.com/science/article/pii/S089158491830073X?via%3Dihub

Gutbier B, Neuhauß AK, Reppe K, Ehrler C, Santel A, Kaufmann J, Scholz M, Weissmann N, Morawietz L, Mitchell TJ, Aliberti S, Hippenstiel S, Suttorp N, Witzenrath M; CAPNETZ and PROGRESS study groups

Prognostic and Pathogenic Role of Angiopoietin-1 and -2 in Pneumonia.

Am J Respir Crit Care Med. 2018 Feb 15

https://www.ncbi.nlm.nih.gov/pubmed/29447449

Becker SC, Szyska M, Mensen A, Hellwig K, Otto R, Olfe L, Volk HD, Dörner T, Dörken B, Scheibenbogen C, Schröder J, Hocke AC, Kang Na Il

A comparative analysis of human bone marrow-resident and peripheral memory B cells.

J Allergy Clin Immunol. 2018 Jan 31

https://www.ncbi.nlm.nih.gov/pubmed/29355676

Nerlich A, Mieth M, Letsiou E, Fatykhova D, Zscheppang K, Matsushima AI, Meyer TF, Paasch L, Mitchell T, Tönnies M, Bauer TT, Schneider P, Neudecker J, Rückert J, Eggeling S, Schimek M, Witzenrath M, Suttorp N, Hippenstiel S, Hocke AC

Pneumolysin induced mitochondrial dysfunction leads to release of mitochondrial DNA.

Scientific Reports (2018) 8:182

https://www.nature.com/articles/s41598-017-18468-7

Gutbier B, Schönrock SM, Ehrler C, Haberberger R, Dietert K, Gruber AD, Kummer W, Michalik L, Kübler WM, Hocke AC, Szymanski K, Letsiou E, Lüth A, Schumacher F, Kleuser B, Mitchell TJ, Bertrams W, Schmeck B, Treue D, Klauschen F, Bauer TT, Tönnies M,

Sphingosine kinase 1 regulates inflammation and contributes to acute lung injury in pneumococcal pneumonia via the S1P receptor 2.

Crit Care Med. 2018 Jan 2.

https://www.ncbi.nlm.nih.gov/pubmed/29298188

Schulz C, Lai X, Bertrams W, Jung AL, Sittka-Stark A, Herkt CE, Janga H, Zscheppang K, Stielow C, Schulte L, Hippenstiel S, Vera J, Schmeck B

THP-1-derived macrophages render lung epithelial cells hypo-responsive to Legionella pneumophila - a systems biology study.

Sci Rep. 2017 Sep 20;7(1):11988

https://www.ncbi.nlm.nih.gov/pubmed/28931863

Zscheppang K, Berg J, Hedtrich S, Verheyen L, Wagner DE, Suttorp N, Hippenstiel S, Hocke AC

Human pulmonary 3D models for translational research.

Biotechnol J. 2017 Sep 2

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Berg J, Zscheppang K, Fatykhova D, Tönnies M, Bauer TT, Schneider P, Neudecker J, Rückert JC, Eggeling S, Schimek M, Gruber AD, Suttorp N, Hippenstiel S, Hocke AC

Tyk2 as a target for immune regulation in human viral/bacterial pneumonia.

Eur Respir J. 2017 Jul 13;50(1)

http://erj.ersjournals.com/content/50/1/1601953

Peter A, Fatykhova D, Kershaw O, Gruber AD, Rueckert J, Neudecker J, Toennies M, Bauer TT, Schneider P, Schimek M, Eggeling S, Suttorp N, Hocke AC, Hippenstiel S

Localization and pneumococcal alteration of junction proteins in the human alveolar-capillary compartment.

Histochem Cell Biol. 2017 Jun;147(6):707-719

https://www.ncbi.nlm.nih.gov/pubmed/28247028

Hocke AC, Suttorp N, and Hippenstiel S

Human lung ex vivo infection models.

Cell Tissue Res. 2017 Mar;367(3):511-524

https://www.ncbi.nlm.nih.gov/pubmed/27999962

Griss K, Bertrams W, Sittka-Stark A, Seidel K, Stielow C, Hippenstiel S, Suttorp N, Eberhardt M, Wilhelm J, Vera J, Schmeck B

MicroRNAs constitute a negative feedback loop in Streptococcus pneumoniae induced macrophage activation.

J Infect Dis. 2016 Mar 16

http://www.ncbi.nlm.nih.gov/pubmed/26984146

Zahlten J, Herta T, Kabus C, Steinfeldt M, Kershaw O, García P, Hocke AC, Gruber AD, Hübner RH, Steinicke R, Doehn JM, Suttorp N, Hippenstiel S

Role of Pneumococcal Autolysin for KLF4 Expression and Chemokine Secretion in Lung Epithelium.

Am J Respir Cell Mol Biol. 2015 Oct;53(4):544-54

https://www.ncbi.nlm.nih.gov/pubmed/ 25756955

Fatykhova D, Rabes A, Machnik C, Guruprasad K, Pache F, Berg J, Toennies M, Bauer TT, Schneider P, Schimek M, Eggeling S, Mitchell TJ, Mitchell AM, Hilker R, Hain T, Suttorp N, Hippenstiel S, Hocke AC, Opitz B

Serotype 1 and 8 Pneumococci Evade Sensing by Inflammasomes in Human Lung Tissue.

PLoS One. 2015 Aug 28;10(8):e0137108

https://www.ncbi.nlm.nih.gov/pubmed/26317436

Zahlten J, Herta T, Kabus C, Steinfeldt M, Kershaw O, García P, Hocke AC, Gruber AD, Hübner RH, Steinicke R, Doehn JM, Suttorp N, Hippenstiel S

Pneumococci LytA-dependent KLF4 Expression Terminates IL-8 Secretion in Lung Epithelium.

Am J Respir Cell Mol Biol. 2015 Mar 10

http://www.ncbi.nlm.nih.gov/pubmed/25756955

Noe E, Tabeling C, Doehn JM, Naujoks J, Opitz B, Hippenstiel S, Witzenrath M, Klopfleisch R

Juvenile megaesophagus in PKCα-deficient mice is associated with an increase in the segment of the distal esophagus lined by smooth muscle cells.

Ann Anat. 2014 Sep;196(5):365-71

https://www.ncbi.nlm.nih.gov/pubmed/24862691

Knepper J, Schierhorn KL, Becher A, Budt M, Tönnies M, Bauer TT, Schneider P, Neudecker J, Rückert JC, Gruber AD, Suttorp N, Schweiger B, Hippenstiel S, Hocke AC, Wolff T

The novel human influenza A(H7N9) virus is naturally adapted to efficient growth in human lung tissue

MBio. 2013 Oct 8;4(5). pii: e00601-13. doi: 10.1128/mBio.00601-13.

http://www.ncbi.nlm.nih.gov/pubmed/24105764

Hocke AC, Becher A, Knepper J, Peter A, Holland G, Tönnies M, Bauer TT, Schneider P, Neudecker J, Muth D, Wendtner CM, Rückert JC, Drosten C, Gruber AD, Laue M, Suttorp N, Hippenstiel S, Wolff T.

Emerging Human Middle East Respiratory Syndrome Coronavirus Causes Widespread Infection and Alveolar Damage in Human Lungs.

Am J Respir Crit Care Med. 2013 Oct 1;188(7):882-886.

http://www.ncbi.nlm.nih.gov/pubmed/24083868

Bayat B, Tjahjono Y, Sydykov A, Werth S, Hippenstiel S, Weissmann N, Sachs UJ, Santoso S.

Anti-Human Neutrophil Antigen-3a Induced Transfusion-Related Acute Lung Injury in Mice by Direct Disturbance of Lung Endothelial Cells.

Arterioscler Thromb Vasc Biol. 2013 Sep 12. [Epub ahead of print]

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Zahlten J, Steinicke R, Bertrams W, Hocke AC, Scharf S, Schmeck B, Witzenrath M, Hammerschmidt S, Suttorp N, Hippenstiel S.

TLR9- and Src-dependent expression of Krueppel-like factor 4 controls interleukin-10 expression in pneumonia.

Eur Respir J. 2013 Feb;41(2):384-91. Epub 2012 May 31

http://www.ncbi.nlm.nih.gov/pubmed/22653776

Doehn JM, Fischer K, Reppe K, Gutbier B, Tschernig T, Hocke AC, Fischetti VA, Löffler J, Suttorp N, Hippenstiel S, Witzenrath M.

Delivery of the endolysin Cpl-1 by inhalation rescues mice with fatal pneumococcal pneumonia.

J Antimicrob Chemother. 2013 Sep;68(9):2111-7. doi: 10.1093/jac/dkt131. Epub 2013 Apr 30.

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Hocke AC, Berg J, Becher A, Knepper J, Klauschen F, Tönnies M, Bauer TT, Schneider P, Neudecker J, Rückert JC, Gruber AD, Suttorp N, Hippenstiel S, Wolff T.

Reply to Fujino et al.

J Infect Dis. 2013 Feb 15;207(4):693-5. doi: 10.1093/infdis/jis740. Epub 2012 Nov 29.

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Szymanski K, Toennies M, Becher A, Fatykhova D, N’Guessan PD, Gutbier B, Klauschen F, Neuschaefer-Rube F, Schneider P, Rueckert J, Neudecker J, Bauer T, Dalhoff K, Dromann D, Gruber A, Kershaw O, Temmesfeld-Wollbrück B, Suttorp N, Hippenstiel S, Hocke

Streptococcus pneumoniae induced regulation of cyclooxygenase-2 in human lung tissue

Eur Respir J. 2012 Dec;40(6):1458-67. Epub 2012 Mar 22

http://www.ncbi.nlm.nih.gov/pubmed/22441740

Scharf S, Zahlten J, Szymanski K, Hippenstiel S, Suttorp N, N´Guessan PD.

Streptococcus pneumoniae induces human ß-defensin-2 and -3 in human lung epithelium.

Exp Lung Res. 2012 Mar;38(2):100-10. doi: 10.3109/01902148.2011.652802.

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Eitel J, Meixenberger K, van Laak C, Orlovski C, Hocke A, Schmeck B, Hippenstiel S, N’Guessan PD, Suttorp N, Opitz B

Rac1 regulates the NLRP3 inflammasome which mediates IL-1beta production in Chlamydophila pneumoniae infected human mononuclear cells.

PLoS One. 2012;7(1):e30379. doi: 10.1371/journal.pone.0030379. Epub 2012 Jan 20.

http://www.ncbi.nlm.nih.gov/pubmed/22276187

Müller HC, Hocke AC, Hellwig K, Gutbier B, Peters H, Schönrock SM, Tschernig T, Schmiedl A, Hippenstiel S, N´Guessan PD, Rosseau S, Suttorp N, Witzenrath M.

The Sphingosine-1 Phosphate receptor agonist FTY720 dose dependently affected endothelial integrity in vitro and aggravated ventilator-induced lung injury in mice.

Pulm Pharmacol Ther. 2011 Aug;24(4):377-85. doi: 10.1016/j.pupt.2011.01.017. Epub 2011 Mar 23.

http://www.ncbi.nlm.nih.gov/pubmed/21419858

Müller HC, Witzenrath M, Tschernig T, Gutbier B, Hippenstiel S, Santel A, Suttorp N, Rosseau S.

Adrenomedullin attenuates ventilator-induced lung injury in mice.

Thorax. 2010 Dec;65(12):1077-84. Epub 2010 Oct 22

http://www.ncbi.nlm.nih.gov/pubmed/20971983

Müller HC, Hellwig K, Rosseau S, Tschernig T, Schmiedl A, Gutbier B, Schmeck B, Hippenstiel S, Peters H, Morawietz L, Suttorp N, Witzenrath M.

Simvastatin attenuates ventilator-induced lung injury in mice.

Crit Care. 2010 14(4):R143. Epub 2010 Jul 30.

http://www.ncbi.nlm.nih.gov/pubmed/20673352

Lorenz J, Zahlten J, Pollok I, Lippmann J, Scharf S, N´Guessan PD, Opitz B, Flieger A, Suttorp N, Hippenstiel S, Schmeck B.

Legionella pneumophila-induced I?B?-dependent expression of interleukin-6 in lung epithelium.

Eur Respir J. 2011 Mar;37(3):648-57. Epub 2010 Jul 22.

http://www.ncbi.nlm.nih.gov/pubmed/20650996

Scharf S, Vardarova K, Lang F, Schmeck B, Opitz B, Flieger A, Heuner K, Hippenstiel S, Suttorp N, N´Guessan PD.

Legionella pneumophila induces human beta defensin-3 in pulmonary cells.

Respir Res. 2010 Jul 8;11:93.

http://www.ncbi.nlm.nih.gov/pubmed/20615218

Zahlten J, Steinicke R, Opitz B, Eitel J, N´guessan PD, Vinzing M, Witzenrath M, Schmeck B, Hammerschmidt S, Suttorp N, Hippenstiel S.

TLR2- and nucleotide-binding oligomerization domain 2-dependent Krüppel-like factor 2 expression downregulates NF-kappa B-related gene expression.

J Immunol. 2010 Jul 1;185(1):597-604. Epub 2010 Jun 4

http://www.ncbi.nlm.nih.gov/pubmed/20525885