Publications
Bertrams W, Hönzke K, Obermayer B, Tönnies M, Bauer TT, Schneider P, Neudecker J, Rückert JC, Stiewe T, Nist A, Eggeling S, Suttorp N, Wolff T, Hippenstiel S, Schmeck B, Hocke AC
Transcriptomic comparison of primary human lung cells with lung tissue samples and the human A549 lung cell line highlights cell type specific responses during infections with influenza A virus
Sci Rep 12, 2022 Nov 29;12(1):20608.
doi 10.1038/s41598-022-24792-4. https://pubmed.ncbi.nlm.nih.gov/36446841/
Patrono LV, Vrancken B, Budt M, Düx A, Lequime S, Boral S, Gilbert MTP, Gogarten JF, Hoffmann L, Horst D, Merkel K, Morens D, Prepoint B, Schlotterbeck J, Schuenemann VJ, Suchard MA, Taubenberger JK, Tenkhoff L, Urban C, Widulin N, Winter E, Worobey M, Schnalke T, Wolff T, Lemey P, Calvignac-Spencer S.
Archival influenza virus genomes from Europe reveal genomic variability during the 1918 pandemic
Nat Commun. 2022 May 10;13(1):2314. doi: 10.1038/s41467-022-29614-9. https://pubmed.ncbi.nlm.nih.gov/35538057/
Sauerhering L, Kuznetsova I, Kupke A, Meier L, Halwe S, Rohde C, Schmidt J, Morty RE, Danov O, Braun A, Vadász I, Becker S, Herold S.
Cyclosporin A Reveals Potent Antiviral Effects in Preclinical Models of SARS-CoV-2 Infection
Am J Respir Crit Care Med. 2022 Feb 15. doi: 10.1164/rccm.202108-1830LE. Online ahead of print. https://pubmed.ncbi.nlm.nih.gov/35167409/
Wendisch D, Dietrich O, Mari T, von Stillfried S, Ibarra IL, Mittermaier M, Mache C, Chua RL, Knoll R, Timm S, Brumhard S, Krammer T, Zauber H, Hiller AL, Pascual-Reguant A, Mothes R, Bülow RD, Schulze J, Leipold AM, Djudjaj S, Erhard F, Geffers R, Pott F, Kazmierski J, Radke J, Pergantis P, Baßler K, Conrad C, Aschenbrenner AC, Sawitzki B, Landthaler M, Wyler E, Horst D; Deutsche COVID-19 OMICS Initiative (DeCOI), Hippenstiel S, Hocke A, Heppner FL, Uhrig A, Garcia C, Machleidt F, Herold S, Elezkurtaj S, Thibeault C, Witzenrath M, Cochain C, Suttorp N, Drosten C, Goffinet C, Kurth F, Schultze JL, Radbruch H, Ochs M, Eils R, Müller-Redetzky H, Hauser AE, Luecken MD, Theis FJ, Conrad C, Wolff T, Boor P, Selbach M, Saliba AE, Sander LE.
SARS-CoV-2 infection triggers profibrotic macrophage responses and lung fibrosis.
Cell. 2021 Nov 27:S0092-8674(21)01383-0. doi: 10.1016/j.cell.2021.11.033. Epub ahead of print. PMID: 34914922. pubmed.ncbi.nlm.nih.gov/34914922/
Schulze J, Mache C, Balázs A, Frey D, Niemeyer D, Olze H, Dommerich S, Drosten C, Hocke AC, Mall MA, Hippenstiel S, Wolff T.
Analysis of SARS-CoV-2 replication in explant cultures of the human upper respiratory tract reveals broad tissue tropism of wild-type and B.1.1.7 variant viruses.
J Infect Dis. 2021 Oct 15:jiab523. doi: 10.1093/infdis/jiab523. Epub ahead of print. PMID: 34651643; PMCID: PMC8524635. pubmed.ncbi.nlm.nih.gov/34651643/
Shaban MS, Müller C, Mayr-Buro C, Weiser H, Meier-Soelch J, Albert BV, Weber A, Linne U, Hain T, Babayev I, Karl N, Hofmann N, Becker S, Herold S, Schmitz ML, Ziebuhr J, Kracht M.
Multi-level inhibition of coronavirus replication by chemical ER stress.
Nat Commun. 2021 Sep 20;12(1):5536. doi: 10.1038/s41467-021-25551-1. PMID: 34545074; PMCID: PMC8452654. pubmed.ncbi.nlm.nih.gov/34545074/
Schroeder S, Mache C, Kleine-Weber H, Corman VM, Muth D, Richter A, Fatykhova D, Memish ZA, Stanifer ML, Boulant S, Gultom M, Dijkman R, Eggeling S, Hocke A, Hippenstiel S, Thiel V, Pöhlmann S, Wolff T, Müller MA, Drosten C.
Functional comparison of MERS-coronavirus lineages reveals increased replicative fitness of the recombinant lineage 5.
Nat Commun. 2021 Sep 7;12(1):5324. doi: 10.1038/s41467-021-25519-1. PMID: 34493730. pubmed.ncbi.nlm.nih.gov/34493730/
Gadalla MR, Morrison E, Serebryakova MV, Han X, Wolff T, Freund C, Kordyukova L, Veit M.
NS1-mediated upregulation of ZDHHC22 acyltransferase in influenza a virus infected cells
Cell Microbiol. 2021 Jun;23(6):e13322. doi: 10.1111/cmi.13322. Epub 2021 Mar 9. https://pubmed.ncbi.nlm.nih.gov/33629465/
Vazquez-Armendariz AI, Herold S.
From Clones to Buds and Branches. The Use of Lung Organoids to Mod Branching Morphogenesis Ex Vivo
Front Cell Dev Biol. 2021 Mar 4;9:631579. doi: 10.3389/fcell.2021.631579. PMID: 33748115; PMCID: PMC7969706. pubmed.ncbi.nlm.nih.gov/33748115/
Myti D, Gunjak M, Casado F, Khaghani Raziabad S, Nardiello C, Vadasz I, Herold S, Pryhuber G, Seeger W, Morty RE.
Elevated FiO 2 increases SARS-CoV-2 co-receptor expression in respiratory tract epithelium
Am J Physiol Lung Cell Mol Physiol. 2020 Oct 1;319(4):L670-L674. doi: 10.1152/ajplung.00345.2020.
Haralampiev I, Prisner S, Nitzan M, Schade M, Jolmes F, Schreiber M, Loidolt-Krüger M, Jongen K, Chamiolo J, Nilson N, Winter F, Friedman N, Seitz O, Wolff T, Herrmann A.
Selective flexible packaging pathways of the segmented genome of influenza A virus
Nat Commun. 2020 Aug 28;11(1):4355. doi: 10.1038/s41467-020-18108-1. https://pubmed.ncbi.nlm.nih.gov/32859915/
Sauerhering L, Kupke A, Meier L, Dietzel E, Hoppe J, Gruber AD, Gattenloehner S, Witte B, Fink L, Hofmann N, Zimmermann T, Goesmann A, Nist A, Stiewe T, Becker S, Herold S, Peteranderl C.
Cyclophilin Inhibitors Restrict Middle East Respiratory Syndrome Coronavirus Via Interferon λ In Vitro And In Mice
Taghizadeh S, Heiner M, Vazquez-Armendariz AI, Wilhelm J, Herold S, Chen C, Zhang JS, Bellusci S.
Characterization in mice of the resident mesenchymal niche maintaining AT2 stem cell proliferation in homeostasis and disease.
Stem Cells. 2021 Oct;39(10):1382-1394. doi: 10.1002/stem.3423. Epub 2021 Jun 15. PMID: 34048616. pubmed.ncbi.nlm.nih.gov/34048616/
Lauster D, Klenk S, Ludwig K, Nojoumi S, Behren S, Adam L, Stadtmüller M, Saenger S, Zimmler S, Hönzke K, Yao L, Hoffmann U, Bardua M, Hamann A, Witzenrath M, Sander LE, Wolff T, Hocke AC, Hippenstiel S, De Carlo S, Neudecker J, Osterrieder K, Budisa N, Netz RR, Böttcher C, Liese S, Herrmann A, Hackenberger CPR
Phage capsid nanoparticles with defined ligand arrangement block influenza virus entry
Schmoldt C, Vazquez-Armendariz AI, Shalashova I, Selvakumar B, Bremer CM, Peteranderl C, Witte B, Gattenloehner S, Fink L, Vadasz I, Morty RE, Pleschka S, Seeger W, Günther A, Herold S
IRE-1 signaling as putative therapeutic target in influenza virus-induced pneumonia.
Peteranderl C, Kuznetsova I, Schulze J, Hardt M, Lecuona E, Sznajder JI, Vadász I, Morty RE, Pleschka S, Wolff T, Herold S
Influenza A virus infection induces apical redistribution of Na+, K+-ATPase in lung epithelial cells in vitro and in vivo.
Amarelle L, Katzen J, Shigemura M, Welch LC, Cajigas H, Peteranderl C, Celli D, Herold S, Lecuona E, Szanjder JI
Cardiac glycosides decrease influenza virus replication by inhibiting cell protein translational machinery.
Am J Physiol Lung Cell Mol Physiol. 2019 Jun 1;316(6):L1094-L1106.
Scheller N, Herold S, Kellner R, Bertrams W, Jung AL, Janga H, Greulich T, Schulte LN, Vogelmeier CF, Lohmeyer J, Schmeck B
Proviral MicroRNAs Detected in Extracellular Vesicles From Bronchoalveolar Lavage Fluid of Patients With Influenza Virus-Induced Acute Respiratory Distress Syndrome.
J Infect Dis. 2019 Jan 29;219(4):540-543
Grund C, Hoffmann D, Ulrich R, Naguib M, Schinköthe J, Hoffmann B, Harder T, Saenger S, Zscheppang K, Tönnies M, Hippenstiel S, Hocke A, Wolff T, Beer M.
A novel European H5N8 influenza A virus has increased virulence in ducks but low zoonotic potential
Kalymbetova TV, Selvakumar B, Rodriguez-Castillo JA, Gunjak M, Malainou C, Heindl MR, Moiseenko A, Chao CM, Vadasz I, Mayer K, Lohmeyer J, Bellusci S, Bottcher-Friebertshauser E, Seeger W, Herold S, Morty RE
Resident alveolar macrophages are master regulators of arrested alveolarization in experimental bronchopulmonary dysplasia.
J Pathol. 2018 Jun;245(2):153-159
Dietert K, Nouailles G, Gutbier B, Reppe K, Berger S, Jiang X, Schauer AE, Hocke AC, Herold S, Slevogt H, Witzenrath M, Suttorp N, Gruber AD
Digital Image Analyses on Whole Lung Slides in Mouse Models of Acute Pneumonia.
Am J Respir Cell Mol Biol. 2018 Jan 23.
https://www.atsjournals.org/doi/full/10.1165/rcmb.2017-0337MA
Dietert K, Gutbier B, Wienhold SM, Reppe K, Jiang X, Yao L, Chaput C, Naujoks J, Brack M, Kupke A, Peteranderl C, Becker S, von Lachner C, Baal N, Slevogt H, Hocke AC, Witzenrath M, Opitz B, Herold S, Hackstein H, Sander LE, Suttorp N, Gruber AD
Spectrum of pathogen- and model-specific histopathologies in mouse models of acute pneumonia.
PLoS One. 2017 Nov 20;12(11):e0188251
van de Sandt CE, Bárcena M, Koster AJ, Kasper J, Kirkpatrick CJ, Scott DP, de Vries RD, Herold S, Rimmelzwaan GF, Kuiken T, Short KR
Human CD8+ T Cells Damage Noninfected Epithelial Cells during Influenza Virus Infection In Vitro.
Am J Respir Cell Mol Biol. 2017 Nov;57(5):536-546
Gerlach T, Hensen L, Matrosovich T, Bergmann J, Winkler M, Peteranderl C, Klenk HD, Weber F, Herold S, Pöhlmann S, Matrosovich M
pH Optimum of Hemagglutinin-Mediated Membrane Fusion Determines Sensitivity of Influenza A Viruses to the Interferon-Induced Antiviral State and IFITMs.
J Virol. 2017 May 12;91(11). pii: e00246-17
Peteranderl C, Sznajder JI, Herold S and Lecuona E
Inflammatory responses regulating alveolar ion transport during pulmonary infections.
Front Immunol. 2017 Apr 18;8:446
Peteranderl C, Herold S
The Impact of the Interferon/TNF-Related Apoptosis-Inducing Ligand Signaling Axis on Disease Progression in Respiratory Viral Infection and Beyond.
Front Immunol. 2017 Mar 22;8:313
Sadewasser A, Paki K, Eichelbaum K, Bogdanow B, Saenger S, Budt M, Lesch M, Hinz KP, Herrmann A, Meyer TF, Karlas A, Selbach M, Wolff T
Quantitative proteomic approach identifies Vpr binding protein as novel host factor supporting influenza A virus infections in human cells.
Mol Cell Proteomics. 2017 Mar 13
Schierhorn KL, Jolmes F, Bespalowa J, Saenger S, Peteranderl C, Dzieciolowski J, Budt M, Pleschka S, Herrmann A, Herold S, Wolff T
Influenza A virus virulence depends on two amino acids in the N-terminal domain of its NS1 protein facilitating inhibition of PKR.
J Virol. 2017 Mar 1. pii: JVI.00198-17
Chao CM, Yahya F, Moiseenko A, Tiozzo C, Shrestha A, Ahmadvand N, El Agha E, Quantius J, Dilai S, Kheirollahi V, Jones M, Wilhem J, Carraro G, Ehrhardt H, Zimmer KP, Barreto G, Ahlbrecht K, Morty RE, Herold S, Abellar RG, Seeger W, Schermuly R, Zhang JS,
Fgf10 deficiency is causative for lethality in a mouse model of bronchopulmonary dysplasia.
J Pathol. 2017 Jan;241(1):91-103
Schaefer MB, Schaefer CA, Schifferings S, Kuhlmann CR, Urban A, Benscheid U, Fischer T, Hecker M, Morty RE, Vadasz I, Herold S, Witzenrath M, Seeger W, Erdogan A, Mayer K
N-3 vs. n-6 fatty acids differentially influence calcium signalling and adhesion of inflammatory activated monocytes: impact of lipid rafts.
Inflamm Res. 2016 Nov;65(11):881-894
Peteranderl C, Herold S, Schmoldt C
Human Influenza Virus Infections.
Semin Respir Crit Care Med. 2016 Aug;37(4):487-500
Quantius J, Schmoldt C, Vazquez-Armendariz AI, Becker C, El Agha E, Wilhelm J, Morty RE, Vadász I, Mayer K, Gattenloehner S, Fink L, Matrosovich M, Li X, Seeger W, Lohmeyer J, Bellusci S, Herold S
Influenza Virus Infects Epithelial Stem/Progenitor Cells of the Distal Lung: Impact on Fgfr2b-Driven Epithelial Repair.
PLoS Pathog. 2016 Jun 20;12(6):e1005544
Mostafa A, Abdelwhab el-SM, Slanina H, Hussein MA, Kuznetsova I, Schüttler CG, Ziebuhr J, Pleschka S
Phylogenetic analysis of human influenza A/H3N2 viruses isolated in 2015 in Germany indicates significant genetic divergence from vaccine strains.
Arch Virol. 2016 Jun;161(6):1505-15
Peteranderl C, Morales-Nebreda L, Selvakumar B, Lecuona E, Vadász I, Morty RE, Schmoldt C, Bespalowa J, Wolff T, Pleschka S, Mayer K, Gattenloehner S, Fink L, Lohmeyer J, Seeger W, Sznajder JI, Mutlu GM, Budinger GR, Herold S
Macrophage-epithelial paracrine crosstalk inhibits lung edema clearance during influenza infection.
J Clin Invest. 2016 Apr 1;126(4):1566-80
Short K, Kasper J, van der Aa S, Andeweg AC, Zaaraoui-Boutahar F, Goeijenbier M, Richard M, Herold S, Becker C, Scott DP, Limpens R, Koster AJ, Barcena M, Fouchier R, Kirkpatrick CJ, Kuiken T
Influenza virus damages the alveolar barrier by disrupting epithelial cell tight junctions.
Eur Respir J. 2016 Mar;47(3):954-66
Naujoks J, Tabeling C, Dill BD, Hoffmann C, Brown AS, Kunze M, Kempa S, Peter A, Mollenkopf HJ, Dorhoi A, Kershaw O, Gruber AD, Sander LE, Witzenrath M, Herold S, Nerlich A, Hocke AC, van Driel I, Suttorp N, Bedoui S, Hilbi H, Trost M, Opitz B
IFNs Modify the Proteome of Legionella-Containing Vacuoles and Restrict Infection Via IRG1-Derived Itaconic Acid.
PLoS Pathog. 2016 Feb 1;12(2)
Reppe K, Radünzel P, Dietert K, Tschernig T, Wolff T, Hammerschmidt S, Gruber AD, Suttorp N, Witzenrath M
Pulmonary immunostimulation with MALP-2 in influenza virus-infected mice increases survival after pneumococcal superinfection.
Infect Immun. 2015 Dec;83(12):4617-29
Engel O, Akyüz L, da Costa Goncalves AC, Winek K, Dames C, Thielke M, Herold S, Böttcher C, Priller J, Volk HD, Dirnagl U, Meisel C, Meisel A
Cholinergic pathway suppresses pulmonary innate immunity facilitating pneumonia after stroke.
Stroke. 2015 Nov;46(11):3232-40
Recum-Knepper J, Sadewasser A, Weinheimer VK, Wolff T
Fluorescence-Activated Cell Sorting-Based Analysis Reveals an Asymmetric Induction of Interferon-Stimulated Genes in Response to Seasonal Influenza A Virus.
J Virol. 2015 Jul 15;89(14):6982-93
Mühlbauer D, Dzieciolowski J, Hardt M, Hocke A, Schierhorn KL, Mostafa A, Müller C, Wisskirchen C, Herold S, Wolff T, Ziebuhr J, Pleschka S
Influenza virus-induced caspase-dependent enlargement of nuclear pores promotes nuclear export of viral ribonucleoprotein complexes.
J Virol. 2015 Jun 1;89(11):6009-21
Hecker M, Linder T, Ott J, Walmrath HD, Lohmeyer J, Vadász I, Marsh LM, Herold S, Reichert M, Buchbinder A, Morty RE, Bausch B, Fischer T, Schulz R, Grimminger F, Witzenrath M, Barnes M, Seeger W, Mayer K
Immunomodulation by lipid emulsions in pulmonary inflammation: a randomized controlled trial.
Crit Care. 2015 May 12;19:226
Hecker M, Ott J, Sondermann C, Schaefer M, Obert M, Hecker A, Morty RE, Vadasz I, Herold S, Rosengarten B, Witzenrath M, Seeger W, Mayer K
Immunomodulation by fish-oil containing lipid emulsions in murine acute respiratory distress syndrome.
Crit Care. 2014 Apr 29;18(2):R85
Peters DM, Vadász I, Wujak L, Wygrecka M, Olschewski A, Becker C, Herold S, Papp
TGF-ß directs trafficking of the epithelial sodium channel ENaC which has implications for ion and fluid transport in acute lung injury.
Proc Natl Acad Sci U S A. 2014 Jan 21;111(3):E374-83
Herold S, Hoegner K, Vadász I, Gessler T, Wilhelm J, Mayer K, Morty RE, Walmrath
Inhaled GM-CSF as treatment of pneumonia-associated ARDS
Am J Respir Crit Care Med. 2014 Mar 1;189(5):609-11
Witsch TJ, Turowski P, Sakkas E, Niess G, Becker S, Herold S, Mayer K, Vadász I, Roberts JD Jr, Seeger W, Morty RE.
Deregulation of the lysyl hydroxylase matrix cross-linking system in experimental and clinical bronchopulmonary dysplasia.
Am J Physiol Lung Cell Mol Physiol. 2013 Nov 27.
Schwartze JT, Becker S, Sakkas E, Wujak LA, Niess G, Usemann J, Reichenberger F, Herold S, Vadasz I, Mayer K, Seeger W, Morty RE.
Glucocorticoids recruit Tgfbr3 and Smad1 to shift transforming growth factor-ß signaling from the Tgfbr1/Smad2/3 axis to the Acvrl1/Smad1 axis in lung fibroblasts.
J Biol Chem. 2013 Dec 17
Knepper J, Schierhorn KL, Becher A, Budt M, Tönnies M, Bauer TT, Schneider P, Neudecker J, Rückert JC, Gruber AD, Suttorp N, Schweiger B, Hippenstiel S, Hocke AC, Wolff T
The novel human influenza A(H7N9) virus is naturally adapted to efficient growth in human lung tissue
MBio. 2013 Oct 8;4(5). pii: e00601-13. doi: 10.1128/mBio.00601-13.
Hocke AC, Becher A, Knepper J, Peter A, Holland G, Tönnies M, Bauer TT, Schneider P, Neudecker J, Muth D, Wendtner CM, Rückert JC, Drosten C, Gruber AD, Laue M, Suttorp N, Hippenstiel S, Wolff T.
Emerging Human Middle East Respiratory Syndrome Coronavirus Causes Widespread Infection and Alveolar Damage in Human Lungs.
Am J Respir Crit Care Med. 2013 Oct 1;188(7):882-886.
Grzesik BA, Vohwinkel C, Morty RE, Mayer K, Herold S, Seeger W, Vadász I
Efficient gene delivery to primary alveolar epithelial cells by nucleofection.
Am J Physiol Lung Cell Mol Physiol 2013, 305: 786-94
Hackstein H, Kranz S, Lippitsch A, Wachtendorf A, Kershaw O, Gruber AD, Michel G, Lohmeyer J, Bein G, Baal N, Herold S.
Modulation of respiratory dendritic cells during Klebsiella pneumonia infection.
Resp Res 2013 Sept 17;14(1):91 [Epub ahead of print].
Herold S, Gabrielli NM, Vadasz I.
Novel concepts of acute lung injury and alveolo-capillary barrier dysfunction.
Am J Physiol Lung Cell Mol Physiol. 13 Sept 2013, DOI: 10.1152/ajplung.00232.2013
Hecker M, Sommer N, Voigtmann H, Pak O, Mohr A, Wolf M, Vadász I, Herold S, Weissmann N, Morty R, Seeger W, Mayer K.
Impact of Short- and Medium-Chain Fatty Acids on Mitochondrial Function in Severe Inflammation.
JPEN J Parenter Enteral Nutr. 2013 May 23.
Hocke AC, Berg J, Becher A, Knepper J, Klauschen F, Tönnies M, Bauer TT, Schneider P, Neudecker J, Rückert JC, Gruber AD, Suttorp N, Hippenstiel S, Wolff T.
Reply to Fujino et al.
J Infect Dis. 2013 Feb 15;207(4):693-5. doi: 10.1093/infdis/jis740. Epub 2012 Nov 29.
Högner, K., Wolff, T., Pleschka, S. Plog, S., Gruber, A.D., Kalinke, U., Walmrath, H.D., Bodner, J., Gattenlöhner, S., Lewe-Schlosser, P., Matrosovich, M., Seeger, W., Lohmeyer, J. and S. Herold
Macrophage-expressed IFN-ß contributes to apoptotic alveolar epithelial cell injury in severe influenza virus pneumonia.
PLoS Pathog. 2013 Feb;9(2), Epub 2013 Feb 28
Unkel B, Hoegner K, Clausen BE, Lewe-Schlosser P, Bodner J, Gattenloehner S, Seeger W, Lohmeyer J, Herold S
Alveolar epithelial cells orchestrate DC function in murine viral pneumonia.
J Clin Invest 2012, Oct 1;122(10):3652-64
Herold S, Ludwig S, Pleschka S, Wolff T
Apoptosis signaling in influenza virus propagation, innate host defence and lung injury
J Leukoc Biol. 2012 Jul;92(1):75-82. Epub 2012 Feb 17
Koppe U, Högner K, Witzenrath M, Bauer S, Hammerschmidt S, Suttorp N, Herold S, Opitz B.
Streptococcus pneumoniae stimulates a STING- and IFN regulatory factor 3-dependent type I IFN production in macrophages, which regulates RANTES production in macrophages, cocultured alveolar epithelial cells, and mouse lungs.
J Immunol. 2012 Jan 15;188(2):811-7
Pinto R, Herold S, Cakarova L, Hoegner K, Seeger W, Lohmeyer J, Planz O, Pleschka S
Inhibition of influenza virus-induced NF-kappaB and Raf/MEK/ERK activation can reduce both virus titers and cytokine expression simultaneously in vitro and in vivo.
Antiviral Res. 2011 Oct;92(1):45-56. Epub 2011 May 27
Herold S, Tabar TS, Janßen H, Högner, K, Cabanski M, Lewe-Schlosser P, Albrecht J, Driever F, Vadasz I, Seeger W, Steinmüller M, Lohmeyer J
Exudate macrophages attenuate epithelial injury by the release of IL-1 receptor antagonist in gram-negative pneumonia.
Am J Respir Crit Care Med. 2011 May 15;183(10):1380-90. doi: 10.1164/rccm.201009-1431OC. Epub 2011 Jan 28
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