Transregio SFB-TR 84 “Innate Immunity of the Lung: Mechanisms of Pathogen Attack and Host Defence in Pneumonia“

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Publications

Robak OH, Heimesaat MM, Kruglov AA, Prepens S, Ninnemann J, Gutbier B, Reppe K, Hochrein H, Suter M, Kirschning CJ, Marathe V, Buer J, Hornef MW, Schnare M, Schneider P, Witzenrath M, Bereswill S, Steinhoff U, Suttorp N, Sander LE, Chaput C, Opitz B

Antibiotic treatment-induced secondary IgA deficiency enhances susceptibility to Pseudomonas aeruginosa pneumonia.

J Clin Invest. 2018 Jul 16. pii: 97065

www.jci.org/articles/view/97065

Keshavarz M, Skill M, Hollenhorst MI, Pfeil U, Walecki M, Kummer W, Krasteva-Christ G

Caveolin-3 differentially orchestrates cholinergic and serotonergic constriction of murine airways.

Sci Rep. 2018 May 14;8(1)

www.ncbi.nlm.nih.gov/pubmed/29760450

Zakrzewicz D, Didiasova M, Krüger M, Giaimo BD, Borggrefe T, Mieth M, Hocke AC, Zakrzewicz A, Schaefer L, Preissner KT, Wygrecka M

Protein arginine methyltransferase 5 mediates enolase-1 cell surface trafficking in human lung adenocarcinoma cells.

Biochim Biophys Acta. 2018 May;1864(5 Pt A):1816-1827

www.ncbi.nlm.nih.gov/pubmed/29501774

Perniss A, Schmidt N, Gurtner C, Dietert K, Schwengers O, Weigel M, Hempe J, Ewers C, Pfeil U, Gärtner U, Gruber AD, Hain T, Kummer W

Bordetella pseudohinzii targets cilia and impairs tracheal cilia-driven transport in naturally acquired infection in mice.

Sci Rep. 2018 Apr 9;8(1):5681

www.nature.com/articles/s41598-018-23830-4

Ugolini M, Gerhard J, Burkert S, Jensen KJ, Georg P, Ebner F, Thada S, Dietert K, Helbig ET, Opitz B, Kurth F, Dittrich N, Sumanlatha G, Blander JM, Gruber AD, Hartmann S, Boekschoten MV, Suttorp N, Müller M, Jungersen G, Schumann RR, Sander LE

Recognition of microbial viability via TLR8 promotes T follicular helper cell differentiation and vaccine responses.

Nat Immunol  2018

www.nature.com/articles/s41590-018-0068-4

Yang G, Pillich H, White R, Czikora I, Pochic I, Yue Q, Hudel M, Gorshkov B, Verin A, Sridhar S, Isales CM, Eaton DC, Hamacher J, Chakraborty T, Lucas R

Listeriolysin O causes ENaC dysfunction in human airway epithelial cells.

Listeriolysin O causes ENaC dysfunction in human airway epithelial cells

www.ncbi.nlm.nih.gov/pubmed/29439494

Ruiz-Moreno JS, Hamann L, Shah JA, Verbon A, Mockenhaupt FP, Puzianowska-Kuznicka M, Naujoks J, Sander LE, Witzenrath M, Cambier JC, Suttorp N, Schumann RR, Jin L, Hawn TR,  Opitz B,  CAPNETZ Study Group

The common HAQ STING variant impairs cGAS-dependent antibacterial responses and is associated with susceptibility to Legionnaires' disease in humans.

PLoS Pathog. 2018 Jan 3;14(1)

journals.plos.org/plospathogens/article

Frevert CW, Felgenhauer J, Wygrecka M, Nastase MV, Schaefer L.

Danger-Associated Molecular Patterns Derived From the Extracellular Matrix Provide Temporal Control of Innate Immunity.

Danger-Associated Molecular Patterns Derived From the Extracellular Matrix Provide Temporal Control of Innate Immunity

www.ncbi.nlm.nih.gov/pubmed/29290139

Ruiz-Moreno JS, Hamann L, Jin L, Sander LE, Puzianowska-Kuznickad M, Cambier JC, Witzenrath M, Schumann RR, Suttorp N, Opitz B, CAPNETZ Study Group

The cGAS/STING pathway detects Streptococcus pneumoniae but is dispensable for anti-pneumococcal defense in mice and humans.

Infect Immun. 2017 Dec 20. pii: IAI.00849-17

iai.asm.org/content/early/2017/12/13/IAI.00849-17.abstract

Dietert K, Gutbier B, Wienhold SM, Reppe K, Jiang X, Yao L, Chaput C, Naujoks J, Brack M, Kupke A, Peteranderl C, Becker S, von Lachner C, Baal N, Slevogt H, Hocke AC, Witzenrath M, Opitz B, Herold S, Hackstein H, Sander LE, Suttorp N, Gruber AD

Spectrum of pathogen- and model-specific histopathologies in mouse models of acute pneumonia.

PLoS One. 2017 Nov 20;12(11):e0188251

www.ncbi.nlm.nih.gov/pubmed/29155867

Naujoks J, Lippmann, J, Suttorp N, Opitz, B

Innate sensing and cell-autonomous resistance pathways in Legionella pneumophila infection.

Int J Med Microbiol. 2017 Oct 27. pii: S1438-4221(17)30306-5.

www.ncbi.nlm.nih.gov/pubmed/29097162

Hess R, Wujak L, Hesse C, Sewald K, Jonigk D, Warnecke G, Fieguth HG, de Maat S, Maas C, Bonella F, Preissner KT, Weiss B, Schaefer L, Kuebler WM, Markart P, Wygrecka M

Coagulation factor XII regulates inflammatory responses in human lungs.

Thromb Haemost. 2017 Oct 5;117(10):1896-1907

www.ncbi.nlm.nih.gov/pubmed/28816340

Opitz B

Inflammasome Deficiency Makes Pro-resolving Lipid Mediators Great Again.

Am J Respir Crit Care Med. 2017;196:668-669

www.atsjournals.org/doi/abs/10.1164/rccm.201702-0402ED&

Von Klitzing E, Bereswill S, Heimesaat MM

Multi-drug resistant Pseudomonas aeruginosa induce systemic pro-inflammatory immune responses in colonized mice.

Eur J Microbiol Immunol (Bp). 2017 Sep 11;7(3):200-209

www.ncbi.nlm.nih.gov/pubmed/29034109

Puri M, La Pietra L, Mraheil MA, Lucas R, Chakraborty T, Pillich H.

Listeriolysin O Regulates the Expression of Optineurin, an Autophagy Adaptor That Inhibits the Growth of Listeria monocytogenes.

Toxins (Basel). 2017; 9; pii: E273.

www.ncbi.nlm.nih.gov/pubmed/28872615

Seeberger PH, Pereira CL, Khan N, Xiao G, Diago-Navarro E, Reppe K, Opitz B, Fries BC, Witzenrath M

A semi-synthetic glycoconjugate vaccine candidate for carbapenem-resistant Klebsiella pneumoniae.

Angew Chem Int Ed Engl. 2017 Aug 16

www.pubmed.de/gateway/nlm-pubmed/28815890

Keshavarz M, Schwarz H, Hartmann P, Wiegand W, Skill M, Althaus M, Kummer W, Krasteva-Christ G

Caveolin-1: functional insights into its role in muscarine- and serotonin-induced smooth muscle constriction in murine airways.

Front Physiol. 2017 May 15;8:295

www.ncbi.nlm.nih.gov/pubmed/28555112

Czikora I, Alli AA, Sridhar S, Matthay MA, Pillich H, Hudel M, Berisha B, Gorshkov B, Romero MJ, Gonzales J, Wu G, Huo Y, Su Y, Verin AD, Fulton D, Chakraborty T, Eaton DC, Lucas R.

Epithelial Sodium Channel-α Mediates the Protective Effect of the TNF-Derived TIP Peptide in Pneumolysin-Induced Endothelial Barrier Dysfunction.

Front Immunol. 2017; 8:842.

www.ncbi.nlm.nih.gov/pubmed/28785264

Wygrecka M, Kosanovic D, Wujak L, Reppe K, Henneke I, Frey H, Didiasova M, Kwapiszewska G, Marsh LM, Baal N, Hackstein H, Zakrzewicz D, Müller-Redetzky HC, de Maat S, Maas C, Nolte MW, Panousis C, Schermuly RT, Seeger W, Witzenrath M, Schaefer L, Markart P

Antihistone Properties of C1 Esterase Inhibitor Protect against Lung Injury.

Am J Respir Crit Care Med. 2017 Jul 15;196(2):186-199

www.ncbi.nlm.nih.gov/pubmed/28005404

Ekmekciu I, von Klitzing E, Fiebiger U, Escher U, Neumann C, Bacher P, Scheffold A, Kühl AA, Bereswill S, Heimesaat MM

Immune responses to broad-spectrum antibiotic treatment and fecal microbiota transplantation in mice.

Front Immunol. 2017 Apr 19;8:397

www.ncbi.nlm.nih.gov/pubmed/28469619

Chen F, Wang Y, Rafikov R, Haigh S, Zhi WB, Kumar S, Doulias PT, Rafikova O, Pillich H, Chakraborty T, Lucas R, Verin AD, Catravas JD, She JX, Black SM, Fulton DJ.

RhoA S-nitrosylation as a regulatory mechanism influencing endothelial barrier function in response to G+-bacterial toxins.

Biochem Pharmacol. 2016 Dec 22. pii: S0006-2952(16)30494-4.

www.ncbi.nlm.nih.gov/pubmed/28017778

Maurer J, Hupp S, Bischoff C, Foertsch C, Mitchell TJ, Chakraborty T, Iliev AI.

Distinct Neurotoxicity Profile of Listeriolysin O from Listeria monocytogenes.

Toxins (Basel). 2017; 9(1), pii: E34.

www.ncbi.nlm.nih.gov/pubmed/28098781

Patel S, Blaauboer SM, Tucker HR, Mansouri S, Ruiz-Moreno JS, Hamann L, Schumann RR, Opitz B, Jin L

The Common R71H-G230A-R293Q Human TMEM173 Is a Null Allele.

J Immunol December 7, 2016, 1601585

www.jimmunol.org/content/early/2016/12/07/jimmunol.1601585.abstract

Pillich H, Loose M, Zimmer KP, Chakraborty T

Diverse roles of endoplasmic reticulum stress sensors in bacterial infection.

Mol Cell Pediatr. 2016 Dec;3(1):9

www.ncbi.nlm.nih.gov/pubmed/26883353

Zakrzewicz D, Bergmann S, Didiasova M, Giaimo BD, Borggrefe T, Mieth M, Hocke AC, Lochnit G, Schaefer L, Hammerschmidt S, Preissner KT, Wygrecka M

Host-derived extracellular RNA promotes adhesion of Streptococcus pneumoniae to endothelial and epithelial cells.

Sci Rep. 2016 Nov 28;6:37758

www.ncbi.nlm.nih.gov/pubmed/27892961

Lucas R, Yue Q, Alli A, Duke BJ, Al-Khalili O, Thai TL, Hamacher J, Sridhar S, Lebedyeva I, Su H, Tzotzos S, Fischer B, Gameiro AF, Loose M, Chakraborty T, Shabbir W, Aufy M, Lemmens-Gruber R, Eaton DC, Czikora I.

The Lectin-like Domain of TNF Increases ENaC Open Probability through a Novel Site at the Interface between the Second Transmembrane and C-terminal Domains of the α-Subunit.

J Biol Chem. 2016; 291:23440-23451.

www.ncbi.nlm.nih.gov/pubmed/27645999

Kostadinova E, Chaput C, Gutbier B, Lippmann J, Sander LE, Mitchell TJ, Suttorp N, Witzenrath M, Opitz B

NLRP3 protects alveolar barrier integrity by an inflammasome-independent increase of epithelial cell adherence

Sci Rep. 2016 Aug 1;6:30943

www.ncbi.nlm.nih.gov/pubmed/27476670

Rabes A, Suttorp N, Opitz B

Inflammasomes in Pneumococcal Infection: Innate Immune Sensing and Bacterial Evasion Strategies.

Curr Top Microbiol Immunol. 2016;397:215-27

www.ncbi.nlm.nih.gov/pubmed/27460812

Garn H, Bahn S, Baune BT, Binder EB, Bisgaard H, Chatila TA, Chavakis T, Culmsee C, Dannlowski U, Gay S, Gern J, Haahtela T, Kircher T, Müller-Ladner U, Neurath MF, Preissner KT, Reinhardt C, Rook G, Russell S, Schmeck B, Stappenbeck T, Steinhoff U, van Os J, Weiss S, Zemlin M, Renz H

Current concepts in chronic inflammatory diseases: Interactions between microbes, cellular metabolism, and inflammation.

J Allergy Clin Immunol. 2016 Jul;138(1):47-56

www.ncbi.nlm.nih.gov/pubmed/27373325

Winek K, Engel O, Koduah P, Heimesaat MM, Fischer A, Bereswill S, Dames C, Kershaw O, Gruber AD, Curato C, Oyama N, Meisel C, Meisel A, Dirnagl U

Depletion of cultivatable gut microbiota by broad-spectrum antibiotic pretreatment worsens outcome after murine stroke.

Stroke. 2016 May;47(5):1354-63

www.ncbi.nlm.nih.gov/pubmed/27056982

Winek K, Engel O, Koduah P, Heimesaat MM, Fischer A, Bereswill S, Dames C, Kershaw O, Gruber AD, Curato C, Oyama N, Meisel C, Meisel A, Dirnagl U

Depletion of cultivatable gut microbiota by broad-spectrum antibiotic pretreatment worsens outcome after murine stroke.

Stroke. 2016 May;47(5):1354-63

www.ncbi.nlm.nih.gov/pubmed/27056982

Tabeling C, Noe E, Naujoks J, Doehn JM, Hippenstiel S, Opitz B, Suttorp N, Klopfleisch R, Witzenrath M

PKCα Deficiency in Mice Is Associated with Pulmonary Vascular Hyperresponsiveness to Thromboxane A2 and Increased Thromboxane Receptor Expression.

J Vasc Res. 2015;52(4):279-88

www.ncbi.nlm.nih.gov/pubmed/26890419

Pillich H, Loose M, Zimmer KP, Chakraborty T

Diverse roles of endoplasmic reticulum stress sensors in bacterial infection.

Mol Cell Pediatr., 2016, 3(1):9

www.ncbi.nlm.nih.gov/pubmed/26883353

Naujoks J, Tabeling C, Dill BD, Hoffmann C, Brown AS, Kunze M, Kempa S, Peter A, Mollenkopf HJ, Dorhoi A, Kershaw O, Gruber AD, Sander LE, Witzenrath M, Herold S, Nerlich A, Hocke AC, van Driel I, Suttorp N, Bedoui S, Hilbi H, Trost M, Opitz B

IFNs Modify the Proteome of Legionella-Containing Vacuoles and Restrict Infection Via IRG1-Derived Itaconic Acid.

PLoS Pathog. 2016 Feb 1;12(2)

www.ncbi.nlm.nih.gov/pubmed/26829557

Krasteva-Christ G, Soultanova A, Schütz B, Papadakis T, Weiss C, Deckmann K, Chubanov V, Gudermann T, Voigt A, Meyerhof W, Boehm U, Weihe E, and Kummer W

Identification of cholinergic chemosensory cells in mouse tracheal and laryngeal glandular ducts.

Int Immunopharmacol. 2015 Nov;29(1):158-65

www.ncbi.nlm.nih.gov/pubmed/26033492

Dittrich NP, Kummer W, Clauss WG, Fronius M

Luminal acetylcholine does not affect the activity of the CFTR in tracheal epithelia of pigs.

Int Immunopharmacol. 2015 Nov;29(1):166-72

www.ncbi.nlm.nih.gov/pubmed/26286842

 

Loose M, Pillich H, Chakraborty T.

Fisetin protects against Listeria monocytogenes infection by reducing the listeriolysin O production.

J Infect Dis. 2015; pii:jiv437.

jid.oxfordjournals.org/content/early/2015/09/06/infdis.jiv437.long

Fatykhova D, Rabes A, Machnik C, Guruprasad K, Pache F, Berg J, Toennies M, Bauer TT, Schneider P, Schimek M, Eggeling S, Mitchell TJ, Mitchell AM, Hilker R, Hain T, Suttorp N, Hippenstiel S, Hocke AC, Opitz B

Serotype 1 and 8 Pneumococci Evade Sensing by Inflammasomes in Human Lung Tissue.

PLoS One. 2015 Aug 28;10(8):e0137108

www.ncbi.nlm.nih.gov/pubmed/26317436

Soultanova A, Voigt A, Chubanov V, Gudermann T, Meyerhof W, Boehm U, Kummer W

Cholinergic chemosensory cells of the thymic medulla express the bitter receptor Tas2r131.

Int Immunopharmacol. 2015 Nov;29(1):143-7

www.ncbi.nlm.nih.gov/pubmed/26102274

Müller-Redetzky HC, Wienhold SM, Berg J, Hocke AC, Hippenstiel S, Hellwig K, Gutbier B, Opitz B, Neudecker J, Rückert J, Gruber AC, Kershaw O, Mayer K,  Suttorp N, Witzenrath M

Moxifloxacin is not anti-inflammatory in experimental pneumococcal pneumonia.

J Antimicrob Chemother. 2015 Mar;70(3):830-40

www.ncbi.nlm.nih.gov/pubmed/25406299

Didiasova M, Zakrzewicz D, Magdolen V, Nagaraj C, Bálint Z, Rohde M, Preissner KT, Wygrecka M

STIM1/ORAI1-mediated Ca2+ Influx Regulates Enolase-1 Exteriorization.

J Biol Chem. 2015 May 8;290(19):11983-99

www.ncbi.nlm.nih.gov/pubmed/25805497

Wujak L, Didiasova M, Zakrzewicz D, Frey H, Schaefer L, Wygrecka M

Heparan sulfate proteoglycans mediate factor XIIa binding to the cell surface.

J Biol Chem. 2015 Mar 13;290(11):7027-39

www.ncbi.nlm.nih.gov/pubmed/25589788

Dietert K, Mundhenk L, Erickson NA, Reppe K, Hocke AC, Kummer W, Witzenrath M, Gruber AD

Murine CLCA5 is uniquely expressed in distinct niches of airway epithelial cells.

Histochem Cell Biol. 2015 Mar;143(3):277-87. doi: 10.1007/s00418-014-1279-x.

www.ncbi.nlm.nih.gov/pmc/articles/PMC4317516/

Cabrera-Fuentes HA, Lopez ML, McCurdy S, Fischer S, Meiler S, Baumer Y, Galuska SP, Preissner KT, Boisvert WA

Regulation of monocyte/macrophage polarisation by extracellular RNA.

Thromb Haemost. 2015 Mar;113(3):473-81

www.ncbi.nlm.nih.gov/pubmed/25589344

Rabes A, Zimmermann S, Reppe K, Lang R, Seeberger PH, Suttorp N, Witzenrath M, Lepenies B, Opitz B

The C-type lectin receptor Mincle binds to Streptococcus pneumoniae but plays a limited role in the anti-pneumococcal innate immune response.

PLoS One. 2015 Feb 6;10(2):e0117022

www.ncbi.nlm.nih.gov/pubmed/25658823

Müller-Redetzky HC, Felten M, Hellwig K, Wienhold SM, Naujoks J, Opitz B, Kershaw O, Gruber AD, Suttorp N, Witzenrath M

Increasing the inspiratory time and I:E ratio during mechanical ventilation aggravates ventilator-induced lung injury in mice.

Critical Care 2015, 19:23

www.ncbi.nlm.nih.gov/pubmed/25888164

Loose M, Hudel M, Zimmer KP, Garcia E, Hammerschmidt S, Lucas R, Chakraborty T, Pillich H

Pneumococcal hydrogen peroxide-induced stress signaling regulates inflammatory genes.

J Infect Dis. 2015 Jan 15;211(2):306-16

www.ncbi.nlm.nih.gov/pubmed/25183769

Saffarzadeh M, Preissner KT

Moonlighting proteins dictate the crosstalk between thrombosis and innate immunity.

J Thromb Haemost. 2014 Dec;12(12):2070-3

www.ncbi.nlm.nih.gov/pubmed/25315144

Czikora I, Alli A, Bao HF, Kaftan D, Sridhar S, Apell HJ, Gorshkov B, White R, Zimmermann A, Wendel A, Pauly-Evers M, Hamacher J, Garcia-Gabay I, Fischer B, Verin A, Bagi Z, Pittet JF, Shabbir W, Lemmens-Gruber R, Chakraborty T, Lazrak A, Matthay MA, Eaton DC, Lucas R

A novel tumor necrosis factor-mediated mechanism of direct epithelial sodium channel activation.

Am J Respir Crit Care Med. 2014 Sep 1;190(5):522-32

www.ncbi.nlm.nih.gov/pubmed/25029038

Noe E, Tabeling C, Doehn JM, Naujoks J, Opitz B, Hippenstiel S, Witzenrath M, Klopfleisch R

Juvenile megaesophagus in PKCα-deficient mice is associated with an increase in the segment of the distal esophagus lined by smooth muscle cells.

Ann Anat. 2014 Sep;196(5):365-71

www.ncbi.nlm.nih.gov/pubmed/24862691

Czikora I, Sridhar S, Gorshkov B, Alieva IB, Kasa A, Gonzales J, Potapenko O, Umapathy NS, Pillich H, Rick FG, Block NL, Verin AD, Chakraborty T, Mattay MA, Schally AV, Lucas R.

Protective effect of growth hormone-releasing hormone agonist in bacterial toxin-induced pulmonary barrier dysfunction.

Front Physiol. 2014; 5:259.

www.ncbi.nlm.nih.gov/pubmed/25076911

Deckmann K, Filipski K, Krasteva-Christ G, Fronius M, Althaus M, Rafiq A, Papadakis T, Renno L, Jurastow I, Wessels L, Schütz B, Weihe E, Chubanov V, Gudermann T, Klein J, Bschleipfer T, Kummer W

Bitter triggers acetylcholine release from polymodal urethral chemosensory cells and bladder reflexes.

Proc Natl Acad Sci U S A. 2014 Jun 3;111(22):8287-92

www.ncbi.nlm.nih.gov/pubmed/24843119

Zakrzewicz D, Didiasova M, Zakrzewicz A, Hocke AC, Uhle F, Markart P, Preissner KT, Wygrecka M

The interaction of enolase-1 with caveolae-associated proteins regulates its subcellular localization.

Biochem J. 2014 Jun 1;460(2):295-307

www.ncbi.nlm.nih.gov/pubmed/24628430

Tabeling C, Scheer H, Schönrock SM, Runge F, Gutbier B, Lienau J, Hamelmann E, Opitz B, Suttorp N, Mayer K, Behrens GM, Tschernig T, Witzenrath M

Nucleotide oligomerization domain 1 ligation suppressed murine allergen-specific T-cell proliferation and airway hyperresponsiveness.

Am J Respir Cell Mol Biol. 2014 May;50(5):903-11

www.ncbi.nlm.nih.gov/pubmed/24279792

Müller-Redetzky HC, Will D, Hellwig K, Kummer W, Tschernig T, Pfeil U, Paddenberg R, Menger MD, Kershaw O, Gruber AD, Weissmann N, Hippenstiel S, Suttorp N, Witzenrath M

Mechanical ventilation drives lung injury and sepsis in pneumococcal pneumonia: protection by Adrenomedullin

Crit Care. 2014 Apr 14;18(2):R73

www.ncbi.nlm.nih.gov/pubmed/24731244

Peters DM, Vadász I, Wujak L, Wygrecka M, Olschewski A, Becker C, Herold S, Papp

TGF-ß directs trafficking of the epithelial sodium channel ENaC which has implications for ion and fluid transport in acute lung injury.

Proc Natl Acad Sci U S A. 2014 Jan 21;111(3):E374-83

www.ncbi.nlm.nih.gov/pubmed/24324142

Tabeling C, Scheer H, Schönrock SM, Runge F, Gutbier B, Lienau J, Hamelmann E, Opitz B, Suttorp N, Mayer K, Behrens GM, Tschernig T, Witzenrath M.

NOD1 Ligation Suppressed Murine Allergen-Specific T Cell Proliferation and Airway Hyperresponsiveness.

Am J Respir Cell Mol Biol. 2013 Nov 26.

www.ncbi.nlm.nih.gov/pubmed/24279792

Naujoks J, Opitz B

Bacterial infections and the DNA sensing pathway

Bookchapter DNA Sensing: The impact of dsDNA on Disease and Vaccinology. Edited by Ken Ishii and Jason C.K. Tang; Elsevier

store.elsevier.com/Biological-DNA-Sensor/isbn-9780124047327

Chaput C, Sander LE, Suttorp N, Opitz B

NOD-Like Receptors in Lung Diseases.

Front Immunol. 2013, 4, 393.

www.ncbi.nlm.nih.gov/pubmed/24312100

Mukhametshina RT, Ruhs A, Singh I, Hasan D, Contreras A, Mehta A, Nikam VS, Ahlbrecht K, Carraro G, Cabrera-Fuentes HA, Jiang D, Voswinckel R, Seeger W, Bellusci S, Scharffetter-Kochanek K, Bagaeva TV, Preissner KT, Boettger T, Braun T, Krüger M, Barreto

Quantitative Proteome Analysis of Alveolar Type-II Cells Reveals a Connection of Integrin Receptor Subunits Beta 2/6 and WNT Signaling.

J Proteome Res. 2013 Dec 6;12(12):5598-608. doi: 10.1021/pr400573k. Epub 2013 Nov 18.

www.ncbi.nlm.nih.gov/pubmed/24175614

Lucas R, Czikora I, Sridhar S, Zemskov EA, Oseghale A, Circo S, Cederbaum SD, Chakraborty T, Fulton DJ, Caldwell RW, Romero MJ.

Arginase 1: an unexpected mediator of pulmonary capillary barrier dysfunction in models of acute lung injury.

Front Immunol. 2013, 4:228

www.ncbi.nlm.nih.gov/pubmed/23966993

Lucas R, Czikora I, Sridhar S, Zemskov E, Gorshkov B, Siddaramappa U, Oseghale A, Lawson J, Verin A, Rick FG, Block NL, Pillich H, Romero M, Leustik M, Schally AV, Chakraborty T.

Mini-review: Novel therapeutic strategies to blunt actions of pneumolysin in the lungs.

Toxins (Basel). 2013, 5:1244-1260.

www.ncbi.nlm.nih.gov/pubmed/23860351

Fulde M, Bernardo-García N, Rohde M, Nachtigall N, Frank R, Preissner KT, Klett J, Morreale A, Chhatwal GS, Hermoso JA, Bergmann S.

Pneumococcal phosphoglycerate kinase interacts with plasminogen and its tissue activator.

Thromb Haemost. 2013 Nov 7;111(3). [Epub ahead of print]

www.ncbi.nlm.nih.gov/pubmed/24196407

Jaax ME, Krauel K, Marschall T, Brandt S, Gansler J, Fürll B, Appel B, Fischer S, Block S, Helm CA, Müller S, Preissner KT, Greinacher A

Complex formation with nucleic acids and aptamers alters the antigenic properties of platelet factor 4

Blood. 2013, 122, 272-81

www.ncbi.nlm.nih.gov/pubmed/23673861

Ulm C, Saffarzadeh M, Mahavadi P, Müller S, Prem G, Saboor F, Simon P, Middendorff R, Geyer H, Henneke I, Bayer N, Rinné S, Lütteke T, Böttcher-Friebertshäuser E, Gerardy-Schahn R, Schwarzer D, Mühlenhoff M, Preissner KT, Günther A, Geyer R, Galuska SP

Soluble polysialylated NCAM: a novel player of the innate immune system in the lung

Cell Mol Life Sci. 2013 Oct;70(19):3695-708. doi: 10.1007/s00018-013-1342-0. Epub 2013 Apr 26

www.ncbi.nlm.nih.gov/pubmed/23619613

Helbig ET, Opitz B, Sander LE

Adjuvant immunotherapies as a novel approach to bacterial infections

Immunotherapy. 2013;5, 365-81.

www.ncbi.nlm.nih.gov/pubmed/23557420

Saffarzadeh, M. and Preissner, K.T.,

Fighting against the dark side of neutrophil extracellular traps in disease: manoeuvres for host protection.

Curr Opin Hematol. 2013, 20, 3-9.

www.ncbi.nlm.nih.gov/pubmed/23041718

Fischer, S. and Preissner, K.T.,

Extracellular nucleic acids as novel alarm signals in the vascular system. Mediators of defence and disease.

Hamostaseologie. 2013, 33, 37-42.

www.ncbi.nlm.nih.gov/pubmed/23328880

Gansler J, Jaax M, Leiting S, Appel B, Greinacher A, Fischer S, Preissner KT

Structural requirements for the procoagulant activity of nucleic acids

PLoS One. 2012, 7, e50399. Epub 2012 Nov 30

www.ncbi.nlm.nih.gov/pubmed/23226277

Yu P, Lübben W, Slomka H, Gebler J, Konert M, Cai C, Neubrandt L, Prazeres da Costa O, Paul S, Dehnert S, Döhne K, Thanisch M, Storsberg S, Wiegand L, Kaufmann A, Nain M, Quintanilla-Martinez L, Bettio S, Schnierle B, Kolesnikova L, Becker S, Schnare M, B

Nucleic acid-sensing Toll-like receptors are essential for the control of endogenous retrovirus viremia and ERV-induced tumors

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