Transregio SFB-TR 84 “Innate Immunity of the Lung: Mechanisms of Pathogen Attack and Host Defence in Pneumonia“

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Publications

Scheuermann L, Pei G, Domaszewska T, Zyla J, Oberbeck-Müller D, Bandermann S, Feng Y, Ruiz Moreno JS, Opitz B, Mollenkopf HJ, Kaufmann SHE, Dorhoi A.

Platelets Restrict the Oxidative Burst in Phagocytes and Facilitate Primary Progressive Tuberculosis

Am J Respir Crit Care Med. 2020 Sep 1;202(5):730-744. doi: 10.1164/rccm.201910-2063OC. pubmed.ncbi.nlm.nih.gov/32421376/

Kurth F, Roennefarth M, Thibeault C, Corman VM, Müller-Redetzky H, Mittermaier M, Ruwwe-Glösenkamp C, Heim KM, Krannich A, Zvorc S, Schmidt S, Kretzler L, Dang-Heine C, Rose M, Hummel M, Hocke A, Hübner RH, Opitz B, Mall MA, Röhmel J, Landmesser U, Pieske B, Knauss S, Endres M, Spranger J, Mockenhaupt FP, Tacke F, Treskatsch S, Angermair S, Siegmund B, Spies C, Weber-Carstens S, Eckardt KU, Schürmann D, Uhrig A, Stegemann MS, Zoller T, Drosten C, Suttorp N, Witzenrath M, Hippenstiel S, von Kalle C, Sander LE.

Studying the pathophysiology of coronavirus disease 2019: a protocol for the Berlin prospective COVID-19 patient cohort (Pa-COVID-19).

Infection. 2020 Aug;48(4):619-626.

Schaupp L, Muth S, Rogell L, Kofoed-Branzk M, Melchior F, Lienenklaus S, Ganal-Vonarburg SC, Klein M, Guendel F, Hain T, Schütze K, Grundmann U, Schmitt V, Dorsch M, Spanier J, Larsen PK, Schwanz T, Jäckel S, Reinhardt C, Bopp T, Danckwardt S, Mahnke K, Heinz GA, Mashreghi MF, Durek P, Kalinke U, Kretz O, Huber TB, Weiss S, Wilhelm C, Macpherson AJ, Schild H, Diefenbach A, Probst HC

Microbiota-Induced Type I Interferons Instruct a Poised Basal State of Dendritic Cells.

Cell. 2020 May 3. pii: S0092-8674(20)30485-2

Ugolini M, Gerhard J, Burkert S, Jensen KJ, Georg P, Ebner F, Thada S, Dietert K, Helbig ET, Opitz B, Kurth F, Dittrich N, Sumanlatha G, Blander JM, Gruber AD, Hartmann S, Boekschoten MV, Suttorp N, Müller M, Jungersen G, Schumann RR, Sander LE

Recognition of microbial viability via TLR8 promotes T follicular helper cell differentiation and vaccine responses.

Nat Immunol  2018

https://www.nature.com/articles/s41590-018-0068-4

Ruiz-Moreno JS, Hamann L, Shah JA, Verbon A, Mockenhaupt FP, Puzianowska-Kuznicka M, Naujoks J, Sander LE, Witzenrath M, Cambier JC, Suttorp N, Schumann RR, Jin L, Hawn TR,  Opitz B,  CAPNETZ Study Group

The common HAQ STING variant impairs cGAS-dependent antibacterial responses and is associated with susceptibility to Legionnaires' disease in humans.

PLoS Pathog. 2018 Jan 3;14(1)

http://journals.plos.org/plospathogens/article?id=10.1371/journal.ppat.1006829

Ruiz-Moreno JS, Hamann L, Jin L, Sander LE, Puzianowska-Kuznickad M, Cambier JC, Witzenrath M, Schumann RR, Suttorp N, Opitz B, CAPNETZ Study Group

The cGAS/STING pathway detects Streptococcus pneumoniae but is dispensable for anti-pneumococcal defense in mice and humans.

Infect Immun. 2017 Dec 20. pii: IAI.00849-17

http://iai.asm.org/content/early/2017/12/13/IAI.00849-17.abstract

Naujoks J, Lippmann, J, Suttorp N, Opitz, B

Innate sensing and cell-autonomous resistance pathways in Legionella pneumophila infection.

Int J Med Microbiol. 2017 Oct 27. pii: S1438-4221(17)30306-5.

https://www.ncbi.nlm.nih.gov/pubmed/29097162

Opitz B

Inflammasome Deficiency Makes Pro-resolving Lipid Mediators Great Again.

Am J Respir Crit Care Med. 2017;196:668-669

http://www.atsjournals.org/doi/abs/10.1164/rccm.201702-0402ED?url_ver=Z39.88-2003&rfr_id=ori%3Arid%3Acrossref.org&rfr_dat=cr_pub%3Dpubmed&

Seeberger PH, Pereira CL, Khan N, Xiao G, Diago-Navarro E, Reppe K, Opitz B, Fries BC, Witzenrath M

A semi-synthetic glycoconjugate vaccine candidate for carbapenem-resistant Klebsiella pneumoniae.

Angew Chem Int Ed Engl. 2017 Aug 16

https://www.pubmed.de/gateway/nlm-pubmed/28815890

Patel S, Blaauboer SM, Tucker HR, Mansouri S, Ruiz-Moreno JS, Hamann L, Schumann RR, Opitz B, Jin L

The Common R71H-G230A-R293Q Human TMEM173 Is a Null Allele.

J Immunol December 7, 2016, 1601585

http://www.jimmunol.org/content/early/2016/12/07/jimmunol.1601585.abstract

Kostadinova E, Chaput C, Gutbier B, Lippmann J, Sander LE, Mitchell TJ, Suttorp N, Witzenrath M, Opitz B

NLRP3 protects alveolar barrier integrity by an inflammasome-independent increase of epithelial cell adherence

Sci Rep. 2016 Aug 1;6:30943

https://www.ncbi.nlm.nih.gov/pubmed/27476670

Rabes A, Suttorp N, Opitz B

Inflammasomes in Pneumococcal Infection: Innate Immune Sensing and Bacterial Evasion Strategies.

Curr Top Microbiol Immunol. 2016;397:215-27

https://www.ncbi.nlm.nih.gov/pubmed/27460812

Tabeling C, Noe E, Naujoks J, Doehn JM, Hippenstiel S, Opitz B, Suttorp N, Klopfleisch R, Witzenrath M

PKCα Deficiency in Mice Is Associated with Pulmonary Vascular Hyperresponsiveness to Thromboxane A2 and Increased Thromboxane Receptor Expression.

J Vasc Res. 2015;52(4):279-88

https://www.ncbi.nlm.nih.gov/pubmed/26890419

Naujoks J, Tabeling C, Dill BD, Hoffmann C, Brown AS, Kunze M, Kempa S, Peter A, Mollenkopf HJ, Dorhoi A, Kershaw O, Gruber AD, Sander LE, Witzenrath M, Herold S, Nerlich A, Hocke AC, van Driel I, Suttorp N, Bedoui S, Hilbi H, Trost M, Opitz B

IFNs Modify the Proteome of Legionella-Containing Vacuoles and Restrict Infection Via IRG1-Derived Itaconic Acid.

PLoS Pathog. 2016 Feb 1;12(2)

https://www.ncbi.nlm.nih.gov/pubmed/26829557

Fatykhova D, Rabes A, Machnik C, Guruprasad K, Pache F, Berg J, Toennies M, Bauer TT, Schneider P, Schimek M, Eggeling S, Mitchell TJ, Mitchell AM, Hilker R, Hain T, Suttorp N, Hippenstiel S, Hocke AC, Opitz B

Serotype 1 and 8 Pneumococci Evade Sensing by Inflammasomes in Human Lung Tissue.

PLoS One. 2015 Aug 28;10(8):e0137108

https://www.ncbi.nlm.nih.gov/pubmed/26317436

Müller-Redetzky HC, Wienhold SM, Berg J, Hocke AC, Hippenstiel S, Hellwig K, Gutbier B, Opitz B, Neudecker J, Rückert J, Gruber AC, Kershaw O, Mayer K,  Suttorp N, Witzenrath M

Moxifloxacin is not anti-inflammatory in experimental pneumococcal pneumonia.

J Antimicrob Chemother. 2015 Mar;70(3):830-40

http://www.ncbi.nlm.nih.gov/pubmed/25406299

Rabes A, Zimmermann S, Reppe K, Lang R, Seeberger PH, Suttorp N, Witzenrath M, Lepenies B, Opitz B

The C-type lectin receptor Mincle binds to Streptococcus pneumoniae but plays a limited role in the anti-pneumococcal innate immune response.

PLoS One. 2015 Feb 6;10(2):e0117022

http://www.ncbi.nlm.nih.gov/pubmed/25658823

Müller-Redetzky HC, Felten M, Hellwig K, Wienhold SM, Naujoks J, Opitz B, Kershaw O, Gruber AD, Suttorp N, Witzenrath M

Increasing the inspiratory time and I:E ratio during mechanical ventilation aggravates ventilator-induced lung injury in mice.

Critical Care 2015, 19:23

http://www.ncbi.nlm.nih.gov/pubmed/25888164

Noe E, Tabeling C, Doehn JM, Naujoks J, Opitz B, Hippenstiel S, Witzenrath M, Klopfleisch R

Juvenile megaesophagus in PKCα-deficient mice is associated with an increase in the segment of the distal esophagus lined by smooth muscle cells.

Ann Anat. 2014 Sep;196(5):365-71

https://www.ncbi.nlm.nih.gov/pubmed/24862691

Tabeling C, Scheer H, Schönrock SM, Runge F, Gutbier B, Lienau J, Hamelmann E, Opitz B, Suttorp N, Mayer K, Behrens GM, Tschernig T, Witzenrath M

Nucleotide oligomerization domain 1 ligation suppressed murine allergen-specific T-cell proliferation and airway hyperresponsiveness.

Am J Respir Cell Mol Biol. 2014 May;50(5):903-11

https://www.ncbi.nlm.nih.gov/pubmed/24279792

Tabeling C, Scheer H, Schönrock SM, Runge F, Gutbier B, Lienau J, Hamelmann E, Opitz B, Suttorp N, Mayer K, Behrens GM, Tschernig T, Witzenrath M.

NOD1 Ligation Suppressed Murine Allergen-Specific T Cell Proliferation and Airway Hyperresponsiveness.

Am J Respir Cell Mol Biol. 2013 Nov 26.

http://www.ncbi.nlm.nih.gov/pubmed/24279792

Naujoks J, Opitz B

Bacterial infections and the DNA sensing pathway

Bookchapter DNA Sensing: The impact of dsDNA on Disease and Vaccinology. Edited by Ken Ishii and Jason C.K. Tang; Elsevier

http://store.elsevier.com/Biological-DNA-Sensor/isbn-9780124047327

Chaput C, Sander LE, Suttorp N, Opitz B

NOD-Like Receptors in Lung Diseases.

Front Immunol. 2013, 4, 393.

http://www.ncbi.nlm.nih.gov/pubmed/24312100

Helbig ET, Opitz B, Sander LE

Adjuvant immunotherapies as a novel approach to bacterial infections

Immunotherapy. 2013;5, 365-81.

http://www.ncbi.nlm.nih.gov/pubmed/23557420

Yu P, Lübben W, Slomka H, Gebler J, Konert M, Cai C, Neubrandt L, Prazeres da Costa O, Paul S, Dehnert S, Döhne K, Thanisch M, Storsberg S, Wiegand L, Kaufmann A, Nain M, Quintanilla-Martinez L, Bettio S, Schnierle B, Kolesnikova L, Becker S, Schnare M,

Nucleic acid-sensing Toll-like receptors are essential for the control of endogenous retrovirus viremia and ERV-induced tumors

Immunity. 2012 Nov 16;37(5):867-79. doi: 10.1016/j.immuni.2012.07.018.

http://www.ncbi.nlm.nih.gov/pubmed/23142781

Oldenburg M, Krüger A, Ferstl R, Kaufmann A, Nees G, Sigmund A, Bathke B, Lauterbach H, Suter M, Dreher S, Koedel U, Akira S, Kawai T, Buer J, Wagner H, Bauer S, Hochrein H, Kirschning CJ

TLR13 recognizes bacterial 23S rRNA devoid of erythromycin resistance-forming modification

Science. 2012 Aug 31;337(6098):1111-5. doi: 10.1126/science.1220363. Epub 2012 Jul 19

 

http://www.ncbi.nlm.nih.gov/pubmed/22821982

Koppe U, Suttorp N, Opitz B

Recognition of Streptococcus pneumoniae by the innate immune system.

Cell Microbiol. 2012 Apr;14(4):460-6. doi: 10.1111/j.1462-5822.2011.01746.x. Epub 2012 Feb 8

http://www.ncbi.nlm.nih.gov/pubmed/22212419

Jöckel S, Nees G, Sommer R, Zhao Y, Cherkasov D, Hori H, Ehm G, Schnare M, Nain M, Kaufmann A, Bauer S

The 2´-O-methylation status of a single guanosine controls transfer RNA-mediated Toll-like receptor 7 activation or inhibition

J Exp Med. 2012 Feb 13;209(2):235-41. Epub 2012 Feb 6.

http://www.ncbi.nlm.nih.gov/pubmed/22312111

Eitel J, Meixenberger K, van Laak C, Orlovski C, Hocke A, Schmeck B, Hippenstiel S, N’Guessan PD, Suttorp N, Opitz B

Rac1 regulates the NLRP3 inflammasome which mediates IL-1beta production in Chlamydophila pneumoniae infected human mononuclear cells.

PLoS One. 2012;7(1):e30379. doi: 10.1371/journal.pone.0030379. Epub 2012 Jan 20.

http://www.ncbi.nlm.nih.gov/pubmed/22276187

Koppe U, Högner K, Witzenrath M, Bauer S, Hammerschmidt S, Suttorp N, Herold S, Opitz B.

Streptococcus pneumoniae stimulates a STING- and IFN regulatory factor 3-dependent type I IFN production in macrophages, which regulates RANTES production in macrophages, cocultured alveolar epithelial cells, and mouse lungs.

J Immunol. 2012 Jan 15;188(2):811-7

http://www.ncbi.nlm.nih.gov/pubmed/22156592

Lippmann J, Müller H, Naujoks J, Tabeling C, Shin S, Witzenrath M, Hellwig K, Kirschning CJ, Taylor GA, Barchet W, Bauer S, Suttorp N, Roy CR, Opitz B

Dissection of a type I interferon pathway in controlling bacterial intracellular infection in mice.

Cell Microbiol. 2011 Nov;13(11):1668-82. doi: 10.1111/j.1462-5822.2011.01646.x. Epub 2011 Aug 24

http://www.ncbi.nlm.nih.gov/pubmed/21790939

Witzenrath M, Pache F, Lorenz D, Koppe U, Schönrock S, Meixenberger K, Dorhoi A, Ma J, Holmes A, Trendelenburg G, Heimesaat MM, Bereswill S, van der Linden M, Tschopp J, Mitchell TJ, Suttorp N, Opitz B.

The NLRP3 Inflammasome is Differentially Activated by Pneumolysin Variants and Contributes to Host Defense in Pneumococcal Pneumonia.

J Immunol. 2011 Jul 1;187(1):434-40. Epub 2011 Jun 6.

http://www.ncbi.nlm.nih.gov/pubmed/21646297

Eitel J, Suttorp N, Opitz B.

Innate immune recognition and inflammasome activation in Listeria monocytogenes infection.

Front Microbiol. 2011;1: 149

http://www.ncbi.nlm.nih.gov/pubmed/21607087

Lorenz J, Zahlten J, Pollok I, Lippmann J, Scharf S, N´Guessan PD, Opitz B, Flieger A, Suttorp N, Hippenstiel S, Schmeck B.

Legionella pneumophila-induced I?B?-dependent expression of interleukin-6 in lung epithelium.

Eur Respir J. 2011 Mar;37(3):648-57. Epub 2010 Jul 22.

http://www.ncbi.nlm.nih.gov/pubmed/20650996

Scharf S, Vardarova K, Lang F, Schmeck B, Opitz B, Flieger A, Heuner K, Hippenstiel S, Suttorp N, N´Guessan PD.

Legionella pneumophila induces human beta defensin-3 in pulmonary cells.

Respir Res. 2010 Jul 8;11:93.

http://www.ncbi.nlm.nih.gov/pubmed/20615218

Zahlten J, Steinicke R, Opitz B, Eitel J, N´guessan PD, Vinzing M, Witzenrath M, Schmeck B, Hammerschmidt S, Suttorp N, Hippenstiel S.

TLR2- and nucleotide-binding oligomerization domain 2-dependent Krüppel-like factor 2 expression downregulates NF-kappa B-related gene expression.

J Immunol. 2010 Jul 1;185(1):597-604. Epub 2010 Jun 4

http://www.ncbi.nlm.nih.gov/pubmed/20525885

Messner CB, Demichev V, Wendisch D, Michalick L, White M, Freiwald A, Textoris-Taube K, Vernardis SI, Egger AS, Kreidl M, Ludwig D, Kilian C, Agostini F, Zelezniak A, Thibeault C, Pfeiffer M, Hippenstiel S, Hocke A, von Kalle C, Campbell A, Hayward C, Porteous DJ, Marioni RE, Langenberg C, Lilley KS, Kuebler WM, Mülleder M, Drosten C, Suttorp N, Witzenrath M, Kurth F, Sander LE, Ralser M

Ultra-High-Throughput Clinical Proteomics Reveals Classifiers of COVID-19 Infection

Cell Syst. 2020 Jul 22;11(1):11-24.e4.

Kuebler W, Jordt SE, Liedtke WB

Urgent reconsideration of lung edema as a preventable outcome in COVID-19: inhibition of TRPV4 represents a promising and feasible approach

Am J Physiol Lung Cell Mol Physiol. 2020 Jun 1;318(6):L1239-L1243

Walther T, Kuebler WM

Don't judge too RAShly: the multifaceted role of the renin-angiotensin system and its therapeutic potential in COVID-19.

Am J Physiol Lung Cell Mol Physiol. 2020 May 1;318(5):L1023-L1024.

Lippitsch A, Baal N, Chukovetskyi Y, Cunningham S, Michel G, Dietert K, Gurtner C, Gruber AD, Bein G, Hackstein H

Plasmacytoid dendritic cell depletion modifies FoxP3+ T cell homeostasis and the clinical course of bacterial pneumonia in mice.

J Leukoc Biol. 2019 Jul 2

https://www.ncbi.nlm.nih.gov/pubmed/31265764

Didiasova M, Zakrzewicz D, Schaefer L, Wygrecka M

When Place Matters: Shuttling of Enolase-1 Across Cellular Compartments.

Front Cell Dev Biol. 2019 Apr 26;7:61

https://www.ncbi.nlm.nih.gov/pubmed/31106201

Baal N, Cunningham S, Obermann HL, Thomas J, Lippitsch A, Dietert K, Gruber AD, Kaufmann A, Michel G, Nist A, Stiewe T, Rupp O, Goesmann A, Zukunft S, Fleming I, Bein G, Lohmeyer J, Bauer S, Hackstein H

ADAR1 Is Required for Dendritic Cell Subset Homeostasis and Alveolar Macrophage Function.

J Immunol. 2019 Feb 15;202(4):1099-1111

https://www.ncbi.nlm.nih.gov/pubmed/30651342

Didiasova M, Wujak L, Schaefer L, Wygrecka M.

Factor XII in coagulation, inflammation and beyond.

Cell Signal. 2018 Nov;51:257-265.

Zakrzewicz D, Didiasova M, Krüger M, Giaimo BD, Borggrefe T, Mieth M, Hocke AC, Zakrzewicz A, Schaefer L, Preissner KT, Wygrecka M

Protein arginine methyltransferase 5 mediates enolase-1 cell surface trafficking in human lung adenocarcinoma cells.

Biochim Biophys Acta. 2018 May;1864(5 Pt A):1816-1827

https://www.ncbi.nlm.nih.gov/pubmed/29501774

Frevert CW, Felgenhauer J, Wygrecka M, Nastase MV, Schaefer L.

Danger-Associated Molecular Patterns Derived From the Extracellular Matrix Provide Temporal Control of Innate Immunity.

Danger-Associated Molecular Patterns Derived From the Extracellular Matrix Provide Temporal Control of Innate Immunity

https://www.ncbi.nlm.nih.gov/pubmed/29290139

Hess R, Wujak L, Hesse C, Sewald K, Jonigk D, Warnecke G, Fieguth HG, de Maat S, Maas C, Bonella F, Preissner KT, Weiss B, Schaefer L, Kuebler WM, Markart P, Wygrecka M

Coagulation factor XII regulates inflammatory responses in human lungs.

Thromb Haemost. 2017 Oct 5;117(10):1896-1907

https://www.ncbi.nlm.nih.gov/pubmed/28816340

Wygrecka M, Kosanovic D, Wujak L, Reppe K, Henneke I, Frey H, Didiasova M, Kwapiszewska G, Marsh LM, Baal N, Hackstein H, Zakrzewicz D, Müller-Redetzky HC, de Maat S, Maas C, Nolte MW, Panousis C, Schermuly RT, Seeger W, Witzenrath M, Schaefer L, Markart

Antihistone Properties of C1 Esterase Inhibitor Protect against Lung Injury.

Am J Respir Crit Care Med. 2017 Jul 15;196(2):186-199

https://www.ncbi.nlm.nih.gov/pubmed/28005404

Zakrzewicz D, Bergmann S, Didiasova M, Giaimo BD, Borggrefe T, Mieth M, Hocke AC, Lochnit G, Schaefer L, Hammerschmidt S, Preissner KT, Wygrecka M

Host-derived extracellular RNA promotes adhesion of Streptococcus pneumoniae to endothelial and epithelial cells.

Sci Rep. 2016 Nov 28;6:37758

https://www.ncbi.nlm.nih.gov/pubmed/27892961

Garn H, Bahn S, Baune BT, Binder EB, Bisgaard H, Chatila TA, Chavakis T, Culmsee C, Dannlowski U, Gay S, Gern J, Haahtela T, Kircher T, Müller-Ladner U, Neurath MF, Preissner KT, Reinhardt C, Rook G, Russell S, Schmeck B, Stappenbeck T, Steinhoff U, van

Current concepts in chronic inflammatory diseases: Interactions between microbes, cellular metabolism, and inflammation.

J Allergy Clin Immunol. 2016 Jul;138(1):47-56

https://www.ncbi.nlm.nih.gov/pubmed/27373325

Didiasova M, Zakrzewicz D, Magdolen V, Nagaraj C, Bálint Z, Rohde M, Preissner KT, Wygrecka M

STIM1/ORAI1-mediated Ca2+ Influx Regulates Enolase-1 Exteriorization.

J Biol Chem. 2015 May 8;290(19):11983-99

http://www.ncbi.nlm.nih.gov/pubmed/25805497

Wujak L, Didiasova M, Zakrzewicz D, Frey H, Schaefer L, Wygrecka M

Heparan sulfate proteoglycans mediate factor XIIa binding to the cell surface.

J Biol Chem. 2015 Mar 13;290(11):7027-39

https://www.ncbi.nlm.nih.gov/pubmed/25589788

Cabrera-Fuentes HA, Lopez ML, McCurdy S, Fischer S, Meiler S, Baumer Y, Galuska SP, Preissner KT, Boisvert WA

Regulation of monocyte/macrophage polarisation by extracellular RNA.

Thromb Haemost. 2015 Mar;113(3):473-81

https://www.ncbi.nlm.nih.gov/pubmed/25589344

Saffarzadeh M, Preissner KT

Moonlighting proteins dictate the crosstalk between thrombosis and innate immunity.

J Thromb Haemost. 2014 Dec;12(12):2070-3

https://www.ncbi.nlm.nih.gov/pubmed/25315144

Zakrzewicz D, Didiasova M, Zakrzewicz A, Hocke AC, Uhle F, Markart P, Preissner KT, Wygrecka M

The interaction of enolase-1 with caveolae-associated proteins regulates its subcellular localization.

Biochem J. 2014 Jun 1;460(2):295-307

http://www.ncbi.nlm.nih.gov/pubmed/24628430

Peters DM, Vadász I, Wujak L, Wygrecka M, Olschewski A, Becker C, Herold S, Papp

TGF-ß directs trafficking of the epithelial sodium channel ENaC which has implications for ion and fluid transport in acute lung injury.

Proc Natl Acad Sci U S A. 2014 Jan 21;111(3):E374-83

http://www.ncbi.nlm.nih.gov/pubmed/24324142

Mukhametshina RT, Ruhs A, Singh I, Hasan D, Contreras A, Mehta A, Nikam VS, Ahlbrecht K, Carraro G, Cabrera-Fuentes HA, Jiang D, Voswinckel R, Seeger W, Bellusci S, Scharffetter-Kochanek K, Bagaeva TV, Preissner KT, Boettger T, Braun T, Krüger M, Barreto

Quantitative Proteome Analysis of Alveolar Type-II Cells Reveals a Connection of Integrin Receptor Subunits Beta 2/6 and WNT Signaling.

J Proteome Res. 2013 Dec 6;12(12):5598-608. doi: 10.1021/pr400573k. Epub 2013 Nov 18.

http://www.ncbi.nlm.nih.gov/pubmed/24175614

Fulde M, Bernardo-García N, Rohde M, Nachtigall N, Frank R, Preissner KT, Klett J, Morreale A, Chhatwal GS, Hermoso JA, Bergmann S.

Pneumococcal phosphoglycerate kinase interacts with plasminogen and its tissue activator.

Thromb Haemost. 2013 Nov 7;111(3). [Epub ahead of print]

http://www.ncbi.nlm.nih.gov/pubmed/24196407

Jaax ME, Krauel K, Marschall T, Brandt S, Gansler J, Fürll B, Appel B, Fischer S, Block S, Helm CA, Müller S, Preissner KT, Greinacher A

Complex formation with nucleic acids and aptamers alters the antigenic properties of platelet factor 4

Blood. 2013, 122, 272-81

http://www.ncbi.nlm.nih.gov/pubmed/23673861

Ulm C, Saffarzadeh M, Mahavadi P, Müller S, Prem G, Saboor F, Simon P, Middendorff R, Geyer H, Henneke I, Bayer N, Rinné S, Lütteke T, Böttcher-Friebertshäuser E, Gerardy-Schahn R, Schwarzer D, Mühlenhoff M, Preissner KT, Günther A, Geyer R, Galusk

Soluble polysialylated NCAM: a novel player of the innate immune system in the lung

Cell Mol Life Sci. 2013 Oct;70(19):3695-708. doi: 10.1007/s00018-013-1342-0. Epub 2013 Apr 26

http://www.ncbi.nlm.nih.gov/pubmed/23619613

Saffarzadeh, M. and Preissner, K.T.,

Fighting against the dark side of neutrophil extracellular traps in disease: manoeuvres for host protection.

Curr Opin Hematol. 2013, 20, 3-9.

http://www.ncbi.nlm.nih.gov/pubmed/23041718

Fischer, S. and Preissner, K.T.,

Extracellular nucleic acids as novel alarm signals in the vascular system. Mediators of defence and disease.

Hamostaseologie. 2013, 33, 37-42.

http://www.ncbi.nlm.nih.gov/pubmed/23328880

Gansler J, Jaax M, Leiting S, Appel B, Greinacher A, Fischer S, Preissner KT

Structural requirements for the procoagulant activity of nucleic acids

PLoS One. 2012, 7, e50399. Epub 2012 Nov 30

http://www.ncbi.nlm.nih.gov/pubmed/23226277

Zakrzewicz D, Zakrzewicz A, Preissner KT, Markart P, Wygrecka M

Protein Arginine Methyltransferases (PRMTs): Promising Targets for the Treatment of Pulmonary Disorders.

Int J Mol Sci. 2012, 13, 12383-400

http://www.ncbi.nlm.nih.gov/pubmed/23202904

Fischer S, Grantzow T, Pagel JI, Tschernatsch M, Sperandio M, Preissner KT, Deindl E

Extracellular RNA promotes leukocyte recruitment in the vascular system by mobilising proinflammatory cytokines

Thromb Haemost. 2012 Oct;108(4):730-41. Epub 2012 Jul 26.

http://www.ncbi.nlm.nih.gov/pubmed/22836360

Grommes J, Alard JE, Drechsler M, Wantha S, Mörgelin M, Kuebler WM, Jacobs M, von Hundelshausen P, Markart P, Wygrecka M, Preissner KT, Hackeng TM, Koenen RR, Weber C, Soehnlein O

Disruption of platelet-derived chemokine heteromers prevents neutrophil extravasation in acute lung injury.

Am J Respir Crit Care Med. 2012 Mar 15;185(6):628-36

https://www.ncbi.nlm.nih.gov/pubmed/22246174

Saffarzadeh M, Juenemann C, Queisser MA, Lochnit G, Barreto G, Galuska SP, Lohmeyer J, Preissner KT

Neutrophil extracellular traps directly induce epithelial and endothelial cell death: a predominant role of histones

PLoS One. 2012, 7, e32366.

http://www.ncbi.nlm.nih.gov/pubmed/22389696

Wygrecka M, Wilhelm J, Jablonska E, Zakrzewicz D, Preissner KT, Seeger W, Guenther A, Markart P

Shedding of Low Density Lipoprotein Receptor-related Protein-1 in Acute Respiratory Distress Syndrome

Am J Respir Crit Care Med. 2011 Aug 15;184(4):438-48. doi: 10.1164/rccm.201009-1422OC. PMID: 21471105. pubmed.ncbi.nlm.nih.gov/21471105/

Fischer S, Nishio M, Dadkhahi S, Gansler J, Saffarzadeh M, Shibamiyama A, Kral N, Baal N, Koyama T, Deindl E, Preissner KT

Expression and localisation of vascular ribonucleases in endothelial cells

Thromb Haemost. 2011 Feb 1;105(2):345-55. Epub 2010 Nov 23.

http://www.ncbi.nlm.nih.gov/pubmed/21103661

Massberg S, Grahl L, von Bruehl ML, Manukyan D, Pfeiler S, Goosmann C, Brinkmann V, Lorenz M, Bidzhekov K, Khandagale AB, Konrad I, Kennerknecht E, Reges K, Holdenrieder S, Braun S, Reinhardt C, Spannagl M, Preissner KT, Engelmann B

Reciprocal coupling of coagulation and innate immunity via neutrophil serine proteases

Nat Med. 2010 Aug;16(8):887-96. Epub 2010 Aug 1.

http://www.ncbi.nlm.nih.gov/pubmed/20676107

Bertrams W, Griss K, Han M, Seidel K, Hippenstiel S, Suttorp N, Finkernagel F, Wilhelm J, Vogelmeier CF, Schmeck B.

Transcriptional analysis identifies potential biomarkers and molecular regulators in acute malaria infection

Life Sci. 2021 Apr 1;270:119158. doi: 10.1016/j.lfs.2021.119158. Epub 2021 Feb 2. PMID: 33545200. pubmed.ncbi.nlm.nih.gov/33545200/

Michalick L, Weidenfeld S, Grimmer B, Fatykhova D, Solymosi PD, Behrens F, Dohmen M, Brack MC, Schulz S, Thomasch E, Simmons S, Müller-Redetzky H, Suttorp N, Kurth F, Neudecker J, Toennies M, Bauer TT, Eggeling S, Corman VM, Hocke AC, Witzenrath M, Hippenstiel S, Kuebler WM.

Plasma mediators in patients with severe COVID-19 cause lung endothelial barrier failure

Eur Respir J. 2020 Nov 5;2002384. doi: 10.1183/13993003.02384-2020. Online ahead of print.

Mraheil MA, Toque HA, La Pietra L, Hamacher J, Phanthok T, Verin AD, Gonzales J, Su Y, Fulton D, Eaton DC, Chakraborty T, Lucas R.

Dual Role of Hydrogen Peroxide as an Oxidant in Pneumococcal Pneumonia.

Antioxid Redox Signal. 2020 Aug 14

Kurth F, Roennefarth M, Thibeault C, Corman VM, Müller-Redetzky H, Mittermaier M, Ruwwe-Glösenkamp C, Heim KM, Krannich A, Zvorc S, Schmidt S, Kretzler L, Dang-Heine C, Rose M, Hummel M, Hocke A, Hübner RH, Opitz B, Mall MA, Röhmel J, Landmesser U, Pieske B, Knauss S, Endres M, Spranger J, Mockenhaupt FP, Tacke F, Treskatsch S, Angermair S, Siegmund B, Spies C, Weber-Carstens S, Eckardt KU, Schürmann D, Uhrig A, Stegemann MS, Zoller T, Drosten C, Suttorp N, Witzenrath M, Hippenstiel S, von Kalle C, Sander LE.

Studying the pathophysiology of coronavirus disease 2019: a protocol for the Berlin prospective COVID-19 patient cohort (Pa-COVID-19).

Infection. 2020 Aug;48(4):619-626.

Frantz R, Teubner L, Schultze T, La Pietra L, Müller C, Gwozdzinski K, Pillich H, Hain T, Weber-Gerlach M, Panagiotidis GD, Mostafa A, Weber F, Rohde M, Pleschka S, Chakraborty T, Abu Mraheil M.

The secRNome of Listeria monocytogenes Harbors Small Noncoding RNAs That Are Potent Inducers of Beta Interferon.

mBio. 2019. 10(5):e01223-19.

Yang G, Pillich H, White R, Czikora I, Pochic I, Yue Q, Hudel M, Gorshkov B, Verin A, Sridhar S, Isales CM, Eaton DC, Hamacher J, Chakraborty T, Lucas R

Listeriolysin O causes ENaC dysfunction in human airway epithelial cells.

Listeriolysin O causes ENaC dysfunction in human airway epithelial cells

https://www.ncbi.nlm.nih.gov/pubmed/29439494

Puri M, La Pietra L, Mraheil MA, Lucas R, Chakraborty T, Pillich H.

Listeriolysin O regulates the expression of optineurin, an autophagy adaptor that inhibits the growth of Listeria monocytogenes.

Toxins (Basel). 2017; 9; pii: E273.

https://www.ncbi.nlm.nih.gov/pubmed/28872615

Czikora I, Alli AA, Sridhar S, Matthay MA, Pillich H, Hudel M, Berisha B, Gorshkov B, Romero MJ, Gonzales J, Wu G, Huo Y, Su Y, Verin AD, Fulton D, Chakraborty T, Eaton DC, Lucas R.

Epithelial Sodium Channel-https://www.ncbi.nlm.nih.gov/pubmed/28785264

Chen F, Wang Y, Rafikov R, Haigh S, Zhi WB, Kumar S, Doulias PT, Rafikova O, Pillich H, Chakraborty T, Lucas R, Verin AD, Catravas JD, She JX, Black SM, Fulton DJ.

RhoA S-nitrosylation as a regulatory mechanism influencing endothelial barrier function in response to G+-bacterial toxins.

Biochem Pharmacol. 2016 Dec 22. pii: S0006-2952(16)30494-4.

www.ncbi.nlm.nih.gov/pubmed/28017778

Maurer J, Hupp S, Bischoff C, Foertsch C, Mitchell TJ, Chakraborty T, Iliev AI.

Distinct Neurotoxicity Profile of Listeriolysin O from Listeria monocytogenes.

Toxins (Basel). 2017; 9(1), pii: E34.

https://www.ncbi.nlm.nih.gov/pubmed/28098781

Pillich H, Loose M, Zimmer KP, Chakraborty T

Diverse roles of endoplasmic reticulum stress sensors in bacterial infection.

Mol Cell Pediatr. 2016 Dec;3(1):9

https://www.ncbi.nlm.nih.gov/pubmed/26883353

Lucas R, Yue Q, Alli A, Duke BJ, Al-Khalili O, Thai TL, Hamacher J, Sridhar S, Lebedyeva I, Su H, Tzotzos S, Fischer B, Gameiro AF, Loose M, Chakraborty T, Shabbir W, Aufy M, Lemmens-Gruber R, Eaton DC, Czikora I.

The Lectin-like Domain of TNF Increases ENaC Open Probability through a Novel Site at the Interface between the Second Transmembrane and C-terminal Domains of the α-Subunit.

J Biol Chem. 2016; 291:23440-23451.

www.ncbi.nlm.nih.gov/pubmed/27645999

Pillich H, Loose M, Zimmer KP, Chakraborty T

Diverse roles of endoplasmic reticulum stress sensors in bacterial infection.

Mol Cell Pediatr., 2016, 3(1):9

Bacterial infection often leads to cellular damage, primarily marked by loss of cellular integrity and cell death. However, in recent years, it is being increasingly recognized that, in individual cells, there are graded responses collectively termed cell-autonomous defense mechanisms that induce cellular processes designed to limit cell damage, enable repair, and eliminate bacteria. Many of these responses are triggered not by detection of a particular bacterial effector or ligand but rather by their effects on key cellular processes and changes in homeostasis induced by microbial effectors when recognized. These in turn lead to a decrease in essential cellular functions such as protein translation or mitochondrial respiration and the induction of innate immune responses that may be specific to the cellular deficit induced. These processes are often associated with specific cell compartments, e.g., the endoplasmic reticulum (ER). Under non-infection conditions, these systems are generally involved in sensing cellular stress and in inducing and orchestrating the subsequent cellular response. Thus, perturbations of ER homeostasis result in accumulation of unfolded proteins which are detected by ER stress sensors in order to restore the normal condition. The ER is also important during bacterial infection, and bacterial effectors that activate the ER stress sensors have been discovered. Increasing evidence now indicate that bacteria have evolved strategies to differentially activate different arms of ER stress sensors resulting in specific host cell response. In this review, we will describe the mechanisms used by bacteria to activate the ER stress sensors and discuss their role during infection.

http://www.ncbi.nlm.nih.gov/pubmed/26883353

Loose M, Pillich H, Chakraborty T.

Fisetin protects against Listeria monocytogenes infection by reducing the listeriolysin O production.

J Infect Dis. 2015; pii:jiv437.

http://jid.oxfordjournals.org/content/early/2015/09/06/infdis.jiv437.long

Loose M, Hudel M, Zimmer KP, Garcia E, Hammerschmidt S, Lucas R, Chakraborty T, Pillich H

Pneumococcal hydrogen peroxide-induced stress signaling regulates inflammatory genes.

J Infect Dis. 2015 Jan 15;211(2):306-16

http://www.ncbi.nlm.nih.gov/pubmed/25183769

Czikora I, Alli A, Bao HF, Kaftan D, Sridhar S, Apell HJ, Gorshkov B, White R, Zimmermann A, Wendel A, Pauly-Evers M, Hamacher J, Garcia-Gabay I, Fischer B, Verin A, Bagi Z, Pittet JF, Shabbir W, Lemmens-Gruber R, Chakraborty T, Lazrak A, Matthay MA, Eato

A novel tumor necrosis factor-mediated mechanism of direct epithelial sodium channel activation.

Am J Respir Crit Care Med. 2014 Sep 1;190(5):522-32

http://www.ncbi.nlm.nih.gov/pubmed/25029038

Czikora I, Sridhar S, Gorshkov B, Alieva IB, Kasa A, Gonzales J, Potapenko O, Umapathy NS, Pillich H, Rick FG, Block NL, Verin AD, Chakraborty T, Mattay MA, Schally AV, Lucas R.

Protective effect of growth hormone-releasing hormone agonist in bacterial toxin-induced pulmonary barrier dysfunction.

Front Physiol. 2014; 5:259.

http://www.ncbi.nlm.nih.gov/pubmed/25076911

Lucas R, Czikora I, Sridhar S, Zemskov EA, Oseghale A, Circo S, Cederbaum SD, Chakraborty T, Fulton DJ, Caldwell RW, Romero MJ.

Arginase 1: an unexpected mediator of pulmonary capillary barrier dysfunction in models of acute lung injury.

Front Immunol. 2013, 4:228

http://www.ncbi.nlm.nih.gov/pubmed/23966993

Lucas R, Czikora I, Sridhar S, Zemskov E, Gorshkov B, Siddaramappa U, Oseghale A, Lawson J, Verin A, Rick FG, Block NL, Pillich H, Romero M, Leustik M, Schally AV, Chakraborty T.

Mini-review: Novel therapeutic strategies to blunt actions of pneumolysin in the lungs.

Toxins (Basel). 2013, 5:1244-1260.

http://www.ncbi.nlm.nih.gov/pubmed/23860351

Lucas R, Yang G, Gorshkov BA, Zemskov EA, Sridhar S, Umapathy NS, Jezierska-Drutel A, Alieva IB, Leustik M, Hossain H, Fischer B, Catravas JD, Verin AD, Pittet JF, Caldwell RB, Mitchell TJ, Cederbaum SD, Fulton DJ, Matthay MA, Caldwell RW, Romero MJ, Chak

Protein Kinase C-a and Arginase I Mediate Pneumolysin-Induced Pulmonary Endothelial Hyperpermeability.

Am J Respir Cell Mol Biol, 2012, May 10. [Epub ahead of print]

http://www.ncbi.nlm.nih.gov/pubmed/22582175

Pillich H, Loose M, Zimmer KP, Chakraborty T

Activation of the unfolded protein response by Listeria monocytogenes

Cell Microbiol. 2012; 14:949-964.

www.ncbi.nlm.nih.gov/pubmed/22321539

Lucas R, Sridhar S, Rick FG, Gorshkov B, Umapathy NS, Yang G, Oseghale A, Verin AD, Chakraborty T, Matthay MA, Zemskov EA, White R, Block NL, Schally AV.

Agonist of growth hormone-releasing hormone reduces pneumolysin-induced pulmonary permeability edema.

Proc Natl Acad Sci U S A, 2012, 109:2084-2089.

http://www.ncbi.nlm.nih.gov/pubmed/22308467