Publications
Wee BA, Alves J, Lindsay DSJ, Klatt AB, Sargison FA, Cameron RL, Pickering A, Gorzynski J, Corander J, Marttinen P, Opitz B, Smith AJ, Fitzgerald JR.
Population analysis of Legionella pneumophila reveals a basis for resistance to complement-mediated killing
Nat Commun. 2021 Dec 9;12(1):7165. doi: 10.1038/s41467-021-27478-z. https://pubmed.ncbi.nlm.nih.gov/34887398/
Witkowski M, Tizian C, Ferreira-Gomes M, Niemeyer D, Jones TC, Heinrich F, Frischbutter S, Angermair S, Hohnstein T, Mattiola I, Nawrath P, Mc Ewen S, Zocche S, Viviano E, Heinz GA, Maurer M, Kölsch U, Chua RL, Aschman T, Meisel C, Radke J, Sawitzki B, Roehmel J, Allers K, Moos V, Schneider T, Hanitsch L, Mall MA, Conrad C, Radbruch H, Duerr CU, Trapani JA, Marcenaro E, Kallinich T, Corman VM, Kurth F, Sander LE, Drosten C, Treskatsch S, Durek P, Kruglov A, Radbruch A, Mashreghi MF, Diefenbach A.
Untimely TGFβ responses in COVID-19 limit antiviral functions of NK cells
Nature. 2021 Oct 25. doi: 10.1038/s41586-021-04142-6. Epub ahead of print. PMID: 34695836. pubmed.ncbi.nlm.nih.gov/34695836/
Scheuermann L, Pei G, Domaszewska T, Zyla J, Oberbeck-Müller D, Bandermann S, Feng Y, Ruiz Moreno JS, Opitz B, Mollenkopf HJ, Kaufmann SHE, Dorhoi A.
Platelets Restrict the Oxidative Burst in Phagocytes and Facilitate Primary Progressive Tuberculosis
Am J Respir Crit Care Med. 2020 Sep 1;202(5):730-744. doi: 10.1164/rccm.201910-2063OC. pubmed.ncbi.nlm.nih.gov/32421376/
Kurth F, Roennefarth M, Thibeault C, Corman VM, Müller-Redetzky H, Mittermaier M, Ruwwe-Glösenkamp C, Heim KM, Krannich A, Zvorc S, Schmidt S, Kretzler L, Dang-Heine C, Rose M, Hummel M, Hocke A, Hübner RH, Opitz B, Mall MA, Röhmel J, Landmesser U, Pieske B, Knauss S, Endres M, Spranger J, Mockenhaupt FP, Tacke F, Treskatsch S, Angermair S, Siegmund B, Spies C, Weber-Carstens S, Eckardt KU, Schürmann D, Uhrig A, Stegemann MS, Zoller T, Drosten C, Suttorp N, Witzenrath M, Hippenstiel S, von Kalle C, Sander LE.
Studying the pathophysiology of coronavirus disease 2019: a protocol for the Berlin prospective COVID-19 patient cohort (Pa-COVID-19).
Schaupp L, Muth S, Rogell L, Kofoed-Branzk M, Melchior F, Lienenklaus S, Ganal-Vonarburg SC, Klein M, Guendel F, Hain T, Schütze K, Grundmann U, Schmitt V, Dorsch M, Spanier J, Larsen PK, Schwanz T, Jäckel S, Reinhardt C, Bopp T, Danckwardt S, Mahnke K, Heinz GA, Mashreghi MF, Durek P, Kalinke U, Kretz O, Huber TB, Weiss S, Wilhelm C, Macpherson AJ, Schild H, Diefenbach A, Probst HC
Microbiota-Induced Type I Interferons Instruct a Poised Basal State of Dendritic Cells.
Wienhold SM, Macrì M, Nouailles G, Dietert K, Gurtner C, Gruber AD, Heimesaat MM, Lienau J, Schumacher F, Kleuser B, Opitz B, Suttorp N, Witzenrath M*, Müller-Redetzky HC*.
Ventilator-induced lung injury is aggravated by antibiotic mediated microbiota depletion in mice.
Crit Care. 2018;22(1):282. https://pubmed.ncbi.nlm.nih.gov/30373626/
Ugolini M, Gerhard J, Burkert S, Jensen KJ, Georg P, Ebner F, Thada S, Dietert K, Helbig ET, Opitz B, Kurth F, Dittrich N, Sumanlatha G, Blander JM, Gruber AD, Hartmann S, Boekschoten MV, Suttorp N, Müller M, Jungersen G, Schumann RR, Sander LE
Recognition of microbial viability via TLR8 promotes T follicular helper cell differentiation and vaccine responses.
Nat Immunol 2018
Ruiz-Moreno JS, Hamann L, Shah JA, Verbon A, Mockenhaupt FP, Puzianowska-Kuznicka M, Naujoks J, Sander LE, Witzenrath M, Cambier JC, Suttorp N, Schumann RR, Jin L, Hawn TR, Opitz B, CAPNETZ Study Group
The common HAQ STING variant impairs cGAS-dependent antibacterial responses and is associated with susceptibility to Legionnaires' disease in humans.
PLoS Pathog. 2018 Jan 3;14(1)
http://journals.plos.org/plospathogens/article?id=10.1371/journal.ppat.1006829
Ruiz-Moreno JS, Hamann L, Jin L, Sander LE, Puzianowska-Kuznickad M, Cambier JC, Witzenrath M, Schumann RR, Suttorp N, Opitz B, CAPNETZ Study Group
The cGAS/STING pathway detects Streptococcus pneumoniae but is dispensable for anti-pneumococcal defense in mice and humans.
Infect Immun. 2017 Dec 20. pii: IAI.00849-17
http://iai.asm.org/content/early/2017/12/13/IAI.00849-17.abstract
Naujoks J, Lippmann, J, Suttorp N, Opitz, B
Innate sensing and cell-autonomous resistance pathways in Legionella pneumophila infection.
Int J Med Microbiol. 2017 Oct 27. pii: S1438-4221(17)30306-5.
Opitz B
Inflammasome Deficiency Makes Pro-resolving Lipid Mediators Great Again.
Am J Respir Crit Care Med. 2017;196:668-669
Seeberger PH, Pereira CL, Khan N, Xiao G, Diago-Navarro E, Reppe K, Opitz B, Fries BC, Witzenrath M
A semi-synthetic glycoconjugate vaccine candidate for carbapenem-resistant Klebsiella pneumoniae.
Angew Chem Int Ed Engl. 2017 Aug 16
Patel S, Blaauboer SM, Tucker HR, Mansouri S, Ruiz-Moreno JS, Hamann L, Schumann RR, Opitz B, Jin L
The Common R71H-G230A-R293Q Human TMEM173 Is a Null Allele.
J Immunol December 7, 2016, 1601585
http://www.jimmunol.org/content/early/2016/12/07/jimmunol.1601585.abstract
Kostadinova E, Chaput C, Gutbier B, Lippmann J, Sander LE, Mitchell TJ, Suttorp N, Witzenrath M, Opitz B
NLRP3 protects alveolar barrier integrity by an inflammasome-independent increase of epithelial cell adherence
Sci Rep. 2016 Aug 1;6:30943
Rabes A, Suttorp N, Opitz B
Inflammasomes in Pneumococcal Infection: Innate Immune Sensing and Bacterial Evasion Strategies.
Curr Top Microbiol Immunol. 2016;397:215-27
Tabeling C, Noe E, Naujoks J, Doehn JM, Hippenstiel S, Opitz B, Suttorp N, Klopfleisch R, Witzenrath M
PKCα Deficiency in Mice Is Associated with Pulmonary Vascular Hyperresponsiveness to Thromboxane A2 and Increased Thromboxane Receptor Expression.
J Vasc Res. 2015;52(4):279-88
Naujoks J, Tabeling C, Dill BD, Hoffmann C, Brown AS, Kunze M, Kempa S, Peter A, Mollenkopf HJ, Dorhoi A, Kershaw O, Gruber AD, Sander LE, Witzenrath M, Herold S, Nerlich A, Hocke AC, van Driel I, Suttorp N, Bedoui S, Hilbi H, Trost M, Opitz B
IFNs Modify the Proteome of Legionella-Containing Vacuoles and Restrict Infection Via IRG1-Derived Itaconic Acid.
PLoS Pathog. 2016 Feb 1;12(2)
Fatykhova D, Rabes A, Machnik C, Guruprasad K, Pache F, Berg J, Toennies M, Bauer TT, Schneider P, Schimek M, Eggeling S, Mitchell TJ, Mitchell AM, Hilker R, Hain T, Suttorp N, Hippenstiel S, Hocke AC, Opitz B
Serotype 1 and 8 Pneumococci Evade Sensing by Inflammasomes in Human Lung Tissue.
PLoS One. 2015 Aug 28;10(8):e0137108
Müller-Redetzky HC, Wienhold SM, Berg J, Hocke AC, Hippenstiel S, Hellwig K, Gutbier B, Opitz B, Neudecker J, Rückert J, Gruber AC, Kershaw O, Mayer K, Suttorp N, Witzenrath M
Moxifloxacin is not anti-inflammatory in experimental pneumococcal pneumonia.
J Antimicrob Chemother. 2015 Mar;70(3):830-40
Rabes A, Zimmermann S, Reppe K, Lang R, Seeberger PH, Suttorp N, Witzenrath M, Lepenies B, Opitz B
The C-type lectin receptor Mincle binds to Streptococcus pneumoniae but plays a limited role in the anti-pneumococcal innate immune response.
PLoS One. 2015 Feb 6;10(2):e0117022
Müller-Redetzky HC, Felten M, Hellwig K, Wienhold SM, Naujoks J, Opitz B, Kershaw O, Gruber AD, Suttorp N, Witzenrath M
Increasing the inspiratory time and I:E ratio during mechanical ventilation aggravates ventilator-induced lung injury in mice.
Critical Care 2015, 19:23
Noe E, Tabeling C, Doehn JM, Naujoks J, Opitz B, Hippenstiel S, Witzenrath M, Klopfleisch R
Juvenile megaesophagus in PKCα-deficient mice is associated with an increase in the segment of the distal esophagus lined by smooth muscle cells.
Ann Anat. 2014 Sep;196(5):365-71
Tabeling C, Scheer H, Schönrock SM, Runge F, Gutbier B, Lienau J, Hamelmann E, Opitz B, Suttorp N, Mayer K, Behrens GM, Tschernig T, Witzenrath M
Nucleotide oligomerization domain 1 ligation suppressed murine allergen-specific T-cell proliferation and airway hyperresponsiveness.
Am J Respir Cell Mol Biol. 2014 May;50(5):903-11
Tabeling C, Scheer H, Schönrock SM, Runge F, Gutbier B, Lienau J, Hamelmann E, Opitz B, Suttorp N, Mayer K, Behrens GM, Tschernig T, Witzenrath M.
NOD1 Ligation Suppressed Murine Allergen-Specific T Cell Proliferation and Airway Hyperresponsiveness.
Am J Respir Cell Mol Biol. 2013 Nov 26.
Naujoks J, Opitz B
Bacterial infections and the DNA sensing pathway
Bookchapter DNA Sensing: The impact of dsDNA on Disease and Vaccinology. Edited by Ken Ishii and Jason C.K. Tang; Elsevier
http://store.elsevier.com/Biological-DNA-Sensor/isbn-9780124047327
Chaput C, Sander LE, Suttorp N, Opitz B
NOD-Like Receptors in Lung Diseases.
Front Immunol. 2013, 4, 393.
Helbig ET, Opitz B, Sander LE
Adjuvant immunotherapies as a novel approach to bacterial infections
Immunotherapy. 2013;5, 365-81.
Yu P, Lübben W, Slomka H, Gebler J, Konert M, Cai C, Neubrandt L, Prazeres da Costa O, Paul S, Dehnert S, Döhne K, Thanisch M, Storsberg S, Wiegand L, Kaufmann A, Nain M, Quintanilla-Martinez L, Bettio S, Schnierle B, Kolesnikova L, Becker S, Schnare M,
Nucleic acid-sensing Toll-like receptors are essential for the control of endogenous retrovirus viremia and ERV-induced tumors
Immunity. 2012 Nov 16;37(5):867-79. doi: 10.1016/j.immuni.2012.07.018.
Oldenburg M, Krüger A, Ferstl R, Kaufmann A, Nees G, Sigmund A, Bathke B, Lauterbach H, Suter M, Dreher S, Koedel U, Akira S, Kawai T, Buer J, Wagner H, Bauer S, Hochrein H, Kirschning CJ
TLR13 recognizes bacterial 23S rRNA devoid of erythromycin resistance-forming modification
Science. 2012 Aug 31;337(6098):1111-5. doi: 10.1126/science.1220363. Epub 2012 Jul 19
Koppe U, Suttorp N, Opitz B
Recognition of Streptococcus pneumoniae by the innate immune system.
Cell Microbiol. 2012 Apr;14(4):460-6. doi: 10.1111/j.1462-5822.2011.01746.x. Epub 2012 Feb 8
Jöckel S, Nees G, Sommer R, Zhao Y, Cherkasov D, Hori H, Ehm G, Schnare M, Nain M, Kaufmann A, Bauer S
The 2´-O-methylation status of a single guanosine controls transfer RNA-mediated Toll-like receptor 7 activation or inhibition
J Exp Med. 2012 Feb 13;209(2):235-41. Epub 2012 Feb 6.
Eitel J, Meixenberger K, van Laak C, Orlovski C, Hocke A, Schmeck B, Hippenstiel S, N’Guessan PD, Suttorp N, Opitz B
Rac1 regulates the NLRP3 inflammasome which mediates IL-1beta production in Chlamydophila pneumoniae infected human mononuclear cells.
PLoS One. 2012;7(1):e30379. doi: 10.1371/journal.pone.0030379. Epub 2012 Jan 20.
Koppe U, Högner K, Witzenrath M, Bauer S, Hammerschmidt S, Suttorp N, Herold S, Opitz B.
Streptococcus pneumoniae stimulates a STING- and IFN regulatory factor 3-dependent type I IFN production in macrophages, which regulates RANTES production in macrophages, cocultured alveolar epithelial cells, and mouse lungs.
J Immunol. 2012 Jan 15;188(2):811-7
Lippmann J, Müller H, Naujoks J, Tabeling C, Shin S, Witzenrath M, Hellwig K, Kirschning CJ, Taylor GA, Barchet W, Bauer S, Suttorp N, Roy CR, Opitz B
Dissection of a type I interferon pathway in controlling bacterial intracellular infection in mice.
Cell Microbiol. 2011 Nov;13(11):1668-82. doi: 10.1111/j.1462-5822.2011.01646.x. Epub 2011 Aug 24
Witzenrath M, Pache F, Lorenz D, Koppe U, Schönrock S, Meixenberger K, Dorhoi A, Ma J, Holmes A, Trendelenburg G, Heimesaat MM, Bereswill S, van der Linden M, Tschopp J, Mitchell TJ, Suttorp N, Opitz B.
The NLRP3 Inflammasome is Differentially Activated by Pneumolysin Variants and Contributes to Host Defense in Pneumococcal Pneumonia.
J Immunol. 2011 Jul 1;187(1):434-40. Epub 2011 Jun 6.
Eitel J, Suttorp N, Opitz B.
Innate immune recognition and inflammasome activation in Listeria monocytogenes infection.
Front Microbiol. 2011;1: 149
Lorenz J, Zahlten J, Pollok I, Lippmann J, Scharf S, N´Guessan PD, Opitz B, Flieger A, Suttorp N, Hippenstiel S, Schmeck B.
Legionella pneumophila-induced I?B?-dependent expression of interleukin-6 in lung epithelium.
Eur Respir J. 2011 Mar;37(3):648-57. Epub 2010 Jul 22.
Scharf S, Vardarova K, Lang F, Schmeck B, Opitz B, Flieger A, Heuner K, Hippenstiel S, Suttorp N, N´Guessan PD.
Legionella pneumophila induces human beta defensin-3 in pulmonary cells.
Respir Res. 2010 Jul 8;11:93.
Zahlten J, Steinicke R, Opitz B, Eitel J, N´guessan PD, Vinzing M, Witzenrath M, Schmeck B, Hammerschmidt S, Suttorp N, Hippenstiel S.
TLR2- and nucleotide-binding oligomerization domain 2-dependent Krüppel-like factor 2 expression downregulates NF-kappa B-related gene expression.
J Immunol. 2010 Jul 1;185(1):597-604. Epub 2010 Jun 4
Pennitz P, Kirsten H, Friedrich VD, Wyler E, Goekeri C, Obermayer B, Heinz GA, Mashreghi MF, Büttner M, Trimpert J, Landthaler M, Suttorp N, Hocke AC, Hippenstiel S, Tönnies M, Scholz M, Kuebler WM, Witzenrath M, Hoenzke K, Nouailles G.
A pulmonologist's guide to perform and analyse cross-species single lung cell transcriptomics
Eur Respir Rev. 2022 Jul 27;31(165):220056. doi: 10.1183/16000617.0056-2022. https://pubmed.ncbi.nlm.nih.gov/35896273/
Wyler E, Adler JM, Eschke K, Teixeira Alves G, Peidli S, Pott F, Kazmierski J, Michalick L, Kershaw O, Bushe J, Andreotti S, Pennitz P, Abdelgawad A, Postmus D, Goffinet C, Kreye J, Reincke SM, Prüss H, Blüthgen N, Gruber AD, Kuebler WM, Witzenrath M, Landthaler M, Nouailles G, Trimpert J.
Key benefits of dexamethasone and antibody treatment in COVID-19 hamster models revealed by single-cell transcriptomics
Mol Ther. 2022 May 4;30(5):1952-1965. doi: 10.1016/j.ymthe.2022.03.014. Epub 2022 Mar 24. https://pubmed.ncbi.nlm.nih.gov/35339689/
Wygrecka M, Birnhuber A, Seeliger B, Michalick L, Pak O, Schultz AS, Schramm F, Zacharias M, Gorkiewicz G, David S, Welte T, Schmidt JJ, Weissmann N, Schermuly RT, Barreto G, Schaefer L, Markart P, Brack MC, Hippenstiel S, Kurth F, Sander LE, Witzenrath M, Kuebler WM, Kwapiszewska G, Preissner KT.
Altered fibrin clot structure and dysregulated fibrinolysis contribute to thrombosis risk in severe COVID-19
Blood Adv. 2022 Feb 8;6(3):1074-1087. doi: 10.1182/bloodadvances.2021004816. pubmed.ncbi.nlm.nih.gov/34861681/
Georg P, Astaburuaga-García R, Bonaguro L, Brumhard S, Michalick L, Lippert LJ, Kostevc T, Gäbel C, Schneider M, Streitz M, Demichev V, Gemünd I, Barone M, Tober-Lau P, Helbig ET, Hillus D, Petrov L, Stein J, Dey HP, Paclik D, Iwert C, Mülleder M, Aulakh SK, Djudjaj S, Bülow RD, Mei HE, Schulz AR, Thiel A, Hippenstiel S, Saliba AE, Eils R, Lehmann I, Mall MA, Stricker S, Röhmel J, Corman VM, Beule D, Wyler E, Landthaler M, Obermayer B, von Stillfried S, Boor P, Demir M, Wesselmann H, Suttorp N, Uhrig A, Müller-Redetzky H, Nattermann J, Kuebler WM, Meisel C, Ralser M, Schultze JL, Aschenbrenner AC, Thibeault C, Kurth F, Sander LE, Blüthgen N, Sawitzki B; PA-COVID-19 Study Group.
Complement activation induces excessive T cell cytotoxicity in severe COVID-19
Cell. 2022 Feb 3;185(3):493-512.e25. doi: 10.1016/j.cell.2021.12.040. Epub 2021 Dec 28. pubmed.ncbi.nlm.nih.gov/35032429/
Ehrlich K, Wilhelm J, Markart P, Weisser H, Wolff JC, Bein G, Pak O, Barreto G, Weissmann N, Schramm F, Seeger W, Schaefer L, Kuebler WM, Wygrecka M; and members of the CAPNETZ Study Group.
Sex-specific differences in plasma levels of FXII, HK, and FXIIa-C1-esterase inhibitor complexes in community-acquired pneumonia.
Am J Physiol Lung Cell Mol Physiol. 2021 Oct 1;321(4):L764-L774. doi: 10.1152/ajplung.00162.2021. Epub 2021 Jul 28. PMID: 34318685. pubmed.ncbi.nlm.nih.gov/34318685/
Brox R, Achenbach S, Hackstein H.
Detection of SARS-CoV-2-independent immunoregulatory activity of COVID-19 convalescent plasma.
Transfusion. 2021 Sep 21. doi: 10.1111/trf.16685. Epub ahead of print. PMID: 34546583. pubmed.ncbi.nlm.nih.gov/34546583/
Pusch L, Brox R, Scheuer K, Yokosawa T, Wu M, Zubiri BA, Spiecker E, Jandt KD, Fischer D, Hackstein H.
Distinct endocytosis and immune activation of poly(lactic-co-glycolic) acid nanoparticles prepared by single- and double-emulsion evaporation.
Nanomedicine (Lond). 2021 Oct;16(23):2075-2094. doi: 10.2217/nnm-2021-0022. Epub 2021 Sep 15. PMID: 34523349. pubmed.ncbi.nlm.nih.gov/34523349/
Birnhuber A, Fliesser E, Gorkiewicz G, Zacharias M, Seeliger B, David S, Welte T, Schmidt J, Olschewski H, Wygrecka M, Kwapiszewska G.
Between inflammation and thrombosis - endothelial cells in COVID-19
Eur Respir J. 2021 May 13:2100377. doi: 10.1183/13993003.00377-2021. Epub ahead of print. PMID: 33958433; PMCID: PMC8112008. pubmed.ncbi.nlm.nih.gov/33958433/
Cunningham S, Hackstein H.
Rapid generation of monocyte-derived antigen-presenting cells with dendritic cell-like properties.
Transfusion. 2021 Jun;61(6):1845-1855. doi: 10.1111/trf.16385. Epub 2021 Mar 30. PMID: 33786883. pubmed.ncbi.nlm.nih.gov/33786883/
Messner CB, Demichev V, Wendisch D, Michalick L, White M, Freiwald A, Textoris-Taube K, Vernardis SI, Egger AS, Kreidl M, Ludwig D, Kilian C, Agostini F, Zelezniak A, Thibeault C, Pfeiffer M, Hippenstiel S, Hocke A, von Kalle C, Campbell A, Hayward C, Porteous DJ, Marioni RE, Langenberg C, Lilley KS, Kuebler WM, Mülleder M, Drosten C, Suttorp N, Witzenrath M, Kurth F, Sander LE, Ralser M
Ultra-High-Throughput Clinical Proteomics Reveals Classifiers of COVID-19 Infection
Kuebler W, Jordt SE, Liedtke WB
Urgent reconsideration of lung edema as a preventable outcome in COVID-19: inhibition of TRPV4 represents a promising and feasible approach
Am J Physiol Lung Cell Mol Physiol. 2020 Jun 1;318(6):L1239-L1243
Walther T, Kuebler WM
Don't judge too RAShly: the multifaceted role of the renin-angiotensin system and its therapeutic potential in COVID-19.
Am J Physiol Lung Cell Mol Physiol. 2020 May 1;318(5):L1023-L1024.
Lippitsch A, Baal N, Chukovetskyi Y, Cunningham S, Michel G, Dietert K, Gurtner C, Gruber AD, Bein G, Hackstein H
Plasmacytoid dendritic cell depletion modifies FoxP3+ T cell homeostasis and the clinical course of bacterial pneumonia in mice.
J Leukoc Biol. 2019 Jul 2
Didiasova M, Zakrzewicz D, Schaefer L, Wygrecka M
When Place Matters: Shuttling of Enolase-1 Across Cellular Compartments.
Front Cell Dev Biol. 2019 Apr 26;7:61
Baal N, Cunningham S, Obermann HL, Thomas J, Lippitsch A, Dietert K, Gruber AD, Kaufmann A, Michel G, Nist A, Stiewe T, Rupp O, Goesmann A, Zukunft S, Fleming I, Bein G, Lohmeyer J, Bauer S, Hackstein H
ADAR1 Is Required for Dendritic Cell Subset Homeostasis and Alveolar Macrophage Function.
J Immunol. 2019 Feb 15;202(4):1099-1111
Didiasova M, Wujak L, Schaefer L, Wygrecka M.
Factor XII in coagulation, inflammation and beyond.
Zakrzewicz D, Didiasova M, Krüger M, Giaimo BD, Borggrefe T, Mieth M, Hocke AC, Zakrzewicz A, Schaefer L, Preissner KT, Wygrecka M
Protein arginine methyltransferase 5 mediates enolase-1 cell surface trafficking in human lung adenocarcinoma cells.
Biochim Biophys Acta. 2018 May;1864(5 Pt A):1816-1827
Frevert CW, Felgenhauer J, Wygrecka M, Nastase MV, Schaefer L.
Danger-Associated Molecular Patterns Derived From the Extracellular Matrix Provide Temporal Control of Innate Immunity.
Danger-Associated Molecular Patterns Derived From the Extracellular Matrix Provide Temporal Control of Innate Immunity
Hess R, Wujak L, Hesse C, Sewald K, Jonigk D, Warnecke G, Fieguth HG, de Maat S, Maas C, Bonella F, Preissner KT, Weiss B, Schaefer L, Kuebler WM, Markart P, Wygrecka M
Coagulation factor XII regulates inflammatory responses in human lungs.
Thromb Haemost. 2017 Oct 5;117(10):1896-1907
Wygrecka M, Kosanovic D, Wujak L, Reppe K, Henneke I, Frey H, Didiasova M, Kwapiszewska G, Marsh LM, Baal N, Hackstein H, Zakrzewicz D, Müller-Redetzky HC, de Maat S, Maas C, Nolte MW, Panousis C, Schermuly RT, Seeger W, Witzenrath M, Schaefer L, Markart
Antihistone Properties of C1 Esterase Inhibitor Protect against Lung Injury.
Am J Respir Crit Care Med. 2017 Jul 15;196(2):186-199
Zakrzewicz D, Bergmann S, Didiasova M, Giaimo BD, Borggrefe T, Mieth M, Hocke AC, Lochnit G, Schaefer L, Hammerschmidt S, Preissner KT, Wygrecka M
Host-derived extracellular RNA promotes adhesion of Streptococcus pneumoniae to endothelial and epithelial cells.
Sci Rep. 2016 Nov 28;6:37758
Garn H, Bahn S, Baune BT, Binder EB, Bisgaard H, Chatila TA, Chavakis T, Culmsee C, Dannlowski U, Gay S, Gern J, Haahtela T, Kircher T, Müller-Ladner U, Neurath MF, Preissner KT, Reinhardt C, Rook G, Russell S, Schmeck B, Stappenbeck T, Steinhoff U, van
Current concepts in chronic inflammatory diseases: Interactions between microbes, cellular metabolism, and inflammation.
J Allergy Clin Immunol. 2016 Jul;138(1):47-56
Didiasova M, Zakrzewicz D, Magdolen V, Nagaraj C, Bálint Z, Rohde M, Preissner KT, Wygrecka M
STIM1/ORAI1-mediated Ca2+ Influx Regulates Enolase-1 Exteriorization.
J Biol Chem. 2015 May 8;290(19):11983-99
Wujak L, Didiasova M, Zakrzewicz D, Frey H, Schaefer L, Wygrecka M
Heparan sulfate proteoglycans mediate factor XIIa binding to the cell surface.
J Biol Chem. 2015 Mar 13;290(11):7027-39
Cabrera-Fuentes HA, Lopez ML, McCurdy S, Fischer S, Meiler S, Baumer Y, Galuska SP, Preissner KT, Boisvert WA
Regulation of monocyte/macrophage polarisation by extracellular RNA.
Thromb Haemost. 2015 Mar;113(3):473-81
Saffarzadeh M, Preissner KT
Moonlighting proteins dictate the crosstalk between thrombosis and innate immunity.
J Thromb Haemost. 2014 Dec;12(12):2070-3
Zakrzewicz D, Didiasova M, Zakrzewicz A, Hocke AC, Uhle F, Markart P, Preissner KT, Wygrecka M
The interaction of enolase-1 with caveolae-associated proteins regulates its subcellular localization.
Biochem J. 2014 Jun 1;460(2):295-307
Peters DM, Vadász I, Wujak L, Wygrecka M, Olschewski A, Becker C, Herold S, Papp
TGF-ß directs trafficking of the epithelial sodium channel ENaC which has implications for ion and fluid transport in acute lung injury.
Proc Natl Acad Sci U S A. 2014 Jan 21;111(3):E374-83
Mukhametshina RT, Ruhs A, Singh I, Hasan D, Contreras A, Mehta A, Nikam VS, Ahlbrecht K, Carraro G, Cabrera-Fuentes HA, Jiang D, Voswinckel R, Seeger W, Bellusci S, Scharffetter-Kochanek K, Bagaeva TV, Preissner KT, Boettger T, Braun T, Krüger M, Barreto
Quantitative Proteome Analysis of Alveolar Type-II Cells Reveals a Connection of Integrin Receptor Subunits Beta 2/6 and WNT Signaling.
J Proteome Res. 2013 Dec 6;12(12):5598-608. doi: 10.1021/pr400573k. Epub 2013 Nov 18.
Fulde M, Bernardo-García N, Rohde M, Nachtigall N, Frank R, Preissner KT, Klett J, Morreale A, Chhatwal GS, Hermoso JA, Bergmann S.
Pneumococcal phosphoglycerate kinase interacts with plasminogen and its tissue activator.
Thromb Haemost. 2013 Nov 7;111(3). [Epub ahead of print]
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Protein Arginine Methyltransferases (PRMTs): Promising Targets for the Treatment of Pulmonary Disorders.
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Thromb Haemost. 2012 Oct;108(4):730-41. Epub 2012 Jul 26.
Grommes J, Alard JE, Drechsler M, Wantha S, Mörgelin M, Kuebler WM, Jacobs M, von Hundelshausen P, Markart P, Wygrecka M, Preissner KT, Hackeng TM, Koenen RR, Weber C, Soehnlein O
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Saffarzadeh M, Juenemann C, Queisser MA, Lochnit G, Barreto G, Galuska SP, Lohmeyer J, Preissner KT
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PLoS One. 2012, 7, e32366.
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Shedding of Low Density Lipoprotein Receptor-related Protein-1 in Acute Respiratory Distress Syndrome
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Massberg S, Grahl L, von Bruehl ML, Manukyan D, Pfeiler S, Goosmann C, Brinkmann V, Lorenz M, Bidzhekov K, Khandagale AB, Konrad I, Kennerknecht E, Reges K, Holdenrieder S, Braun S, Reinhardt C, Spannagl M, Preissner KT, Engelmann B
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Introducing quality measures in an academic research consortium: Lessons and recommendation from implementing an ad hoc quality management system for organ model research
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A pulmonologist's guide to perform and analyse cross-species single lung cell transcriptomics
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Human lungs show limited permissiveness for SARS-CoV-2 due to scarce ACE2 levels but virus-induced expansion of inflammatory macrophages
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Altered fibrin clot structure and dysregulated fibrinolysis contribute to thrombosis risk in severe COVID-19
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Coronavirus Disease (COVID-19) Control between Drug Repurposing and Vaccination: A Comprehensive Overview
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J Infect Dis. 2021 Oct 15:jiab523. doi: 10.1093/infdis/jiab523. Epub ahead of print. PMID: 34651643; PMCID: PMC8524635. pubmed.ncbi.nlm.nih.gov/34651643/
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A time-resolved proteomic and prognostic map of COVID-19
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Transcriptional analysis identifies potential biomarkers and molecular regulators in acute malaria infection
Life Sci. 2021 Apr 1;270:119158. doi: 10.1016/j.lfs.2021.119158. Epub 2021 Feb 2. PMID: 33545200. pubmed.ncbi.nlm.nih.gov/33545200/
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Streptococcus pneumoniae and Its Virulence Factors H2O2 and Pneumolysin Are Potent Mediators of the Acute Chest Syndrome in Sickle Cell Disease
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Plasma mediators in patients with severe COVID-19 cause lung endothelial barrier failure
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Studying the pathophysiology of coronavirus disease 2019: a protocol for the Berlin prospective COVID-19 patient cohort (Pa-COVID-19).
Lucas R, Hadizamani Y, Gonzales J, Gorshkov B, Bodmer T, Berthiaume Y, Moehrlen U, Lode H, Huwer H, Hudel M, Mraheil MA, Toque HAF, Chakraborty T, Hamacher J.
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The secRNome of Listeria monocytogenes Harbors Small Noncoding RNAs That Are Potent Inducers of Beta Interferon.
Yang G, Pillich H, White R, Czikora I, Pochic I, Yue Q, Hudel M, Gorshkov B, Verin A, Sridhar S, Isales CM, Eaton DC, Hamacher J, Chakraborty T, Lucas R
Listeriolysin O causes ENaC dysfunction in human airway epithelial cells.
Listeriolysin O causes ENaC dysfunction in human airway epithelial cells
Puri M, La Pietra L, Mraheil MA, Lucas R, Chakraborty T, Pillich H.
Listeriolysin O regulates the expression of optineurin, an autophagy adaptor that inhibits the growth of Listeria monocytogenes.
Toxins (Basel). 2017; 9; pii: E273.
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RhoA S-nitrosylation as a regulatory mechanism influencing endothelial barrier function in response to G+-bacterial toxins.
Biochem Pharmacol. 2016 Dec 22. pii: S0006-2952(16)30494-4.
Maurer J, Hupp S, Bischoff C, Foertsch C, Mitchell TJ, Chakraborty T, Iliev AI.
Distinct Neurotoxicity Profile of Listeriolysin O from Listeria monocytogenes.
Toxins (Basel). 2017; 9(1), pii: E34.
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Diverse roles of endoplasmic reticulum stress sensors in bacterial infection.
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The Lectin-like Domain of TNF Increases ENaC Open Probability through a Novel Site at the Interface between the Second Transmembrane and C-terminal Domains of the α-Subunit.
J Biol Chem. 2016; 291:23440-23451.
Loose M, Pillich H, Chakraborty T.
Fisetin protects against Listeria monocytogenes infection by reducing the listeriolysin O production.
J Infect Dis. 2015; pii:jiv437.
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Pneumococcal hydrogen peroxide-induced stress signaling regulates inflammatory genes.
J Infect Dis. 2015 Jan 15;211(2):306-16
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A novel tumor necrosis factor-mediated mechanism of direct epithelial sodium channel activation.
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Protective effect of growth hormone-releasing hormone agonist in bacterial toxin-induced pulmonary barrier dysfunction.
Front Physiol. 2014; 5:259.
Lucas R, Czikora I, Sridhar S, Zemskov EA, Oseghale A, Circo S, Cederbaum SD, Chakraborty T, Fulton DJ, Caldwell RW, Romero MJ.
Arginase 1: an unexpected mediator of pulmonary capillary barrier dysfunction in models of acute lung injury.
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Lucas R, Czikora I, Sridhar S, Zemskov E, Gorshkov B, Siddaramappa U, Oseghale A, Lawson J, Verin A, Rick FG, Block NL, Pillich H, Romero M, Leustik M, Schally AV, Chakraborty T.
Mini-review: Novel therapeutic strategies to blunt actions of pneumolysin in the lungs.
Toxins (Basel). 2013, 5:1244-1260.
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