Publications
Wee BA, Alves J, Lindsay DSJ, Klatt AB, Sargison FA, Cameron RL, Pickering A, Gorzynski J, Corander J, Marttinen P, Opitz B, Smith AJ, Fitzgerald JR.
Population analysis of Legionella pneumophila reveals a basis for resistance to complement-mediated killing
Nat Commun. 2021 Dec 9;12(1):7165. doi: 10.1038/s41467-021-27478-z. https://pubmed.ncbi.nlm.nih.gov/34887398/
Witkowski M, Tizian C, Ferreira-Gomes M, Niemeyer D, Jones TC, Heinrich F, Frischbutter S, Angermair S, Hohnstein T, Mattiola I, Nawrath P, Mc Ewen S, Zocche S, Viviano E, Heinz GA, Maurer M, Kölsch U, Chua RL, Aschman T, Meisel C, Radke J, Sawitzki B, Roehmel J, Allers K, Moos V, Schneider T, Hanitsch L, Mall MA, Conrad C, Radbruch H, Duerr CU, Trapani JA, Marcenaro E, Kallinich T, Corman VM, Kurth F, Sander LE, Drosten C, Treskatsch S, Durek P, Kruglov A, Radbruch A, Mashreghi MF, Diefenbach A.
Untimely TGFβ responses in COVID-19 limit antiviral functions of NK cells
Nature. 2021 Oct 25. doi: 10.1038/s41586-021-04142-6. Epub ahead of print. PMID: 34695836. pubmed.ncbi.nlm.nih.gov/34695836/
Scheuermann L, Pei G, Domaszewska T, Zyla J, Oberbeck-Müller D, Bandermann S, Feng Y, Ruiz Moreno JS, Opitz B, Mollenkopf HJ, Kaufmann SHE, Dorhoi A.
Platelets Restrict the Oxidative Burst in Phagocytes and Facilitate Primary Progressive Tuberculosis
Am J Respir Crit Care Med. 2020 Sep 1;202(5):730-744. doi: 10.1164/rccm.201910-2063OC. pubmed.ncbi.nlm.nih.gov/32421376/
Schaupp L, Muth S, Rogell L, Kofoed-Branzk M, Melchior F, Lienenklaus S, Ganal-Vonarburg SC, Klein M, Guendel F, Hain T, Schütze K, Grundmann U, Schmitt V, Dorsch M, Spanier J, Larsen PK, Schwanz T, Jäckel S, Reinhardt C, Bopp T, Danckwardt S, Mahnke K, Heinz GA, Mashreghi MF, Durek P, Kalinke U, Kretz O, Huber TB, Weiss S, Wilhelm C, Macpherson AJ, Schild H, Diefenbach A, Probst HC
Microbiota-Induced Type I Interferons Instruct a Poised Basal State of Dendritic Cells.
Wienhold SM, Macrì M, Nouailles G, Dietert K, Gurtner C, Gruber AD, Heimesaat MM, Lienau J, Schumacher F, Kleuser B, Opitz B, Suttorp N, Witzenrath M*, Müller-Redetzky HC*.
Ventilator-induced lung injury is aggravated by antibiotic mediated microbiota depletion in mice.
Crit Care. 2018;22(1):282. https://pubmed.ncbi.nlm.nih.gov/30373626/
Ugolini M, Gerhard J, Burkert S, Jensen KJ, Georg P, Ebner F, Thada S, Dietert K, Helbig ET, Opitz B, Kurth F, Dittrich N, Sumanlatha G, Blander JM, Gruber AD, Hartmann S, Boekschoten MV, Suttorp N, Müller M, Jungersen G, Schumann RR, Sander LE
Recognition of microbial viability via TLR8 promotes T follicular helper cell differentiation and vaccine responses.
Nat Immunol 2018
Ruiz-Moreno JS, Hamann L, Shah JA, Verbon A, Mockenhaupt FP, Puzianowska-Kuznicka M, Naujoks J, Sander LE, Witzenrath M, Cambier JC, Suttorp N, Schumann RR, Jin L, Hawn TR, Opitz B, CAPNETZ Study Group
The common HAQ STING variant impairs cGAS-dependent antibacterial responses and is associated with susceptibility to Legionnaires' disease in humans.
PLoS Pathog. 2018 Jan 3;14(1)
http://journals.plos.org/plospathogens/article?id=10.1371/journal.ppat.1006829
Ruiz-Moreno JS, Hamann L, Jin L, Sander LE, Puzianowska-Kuznickad M, Cambier JC, Witzenrath M, Schumann RR, Suttorp N, Opitz B, CAPNETZ Study Group
The cGAS/STING pathway detects Streptococcus pneumoniae but is dispensable for anti-pneumococcal defense in mice and humans.
Infect Immun. 2017 Dec 20. pii: IAI.00849-17
http://iai.asm.org/content/early/2017/12/13/IAI.00849-17.abstract
Naujoks J, Lippmann, J, Suttorp N, Opitz, B
Innate sensing and cell-autonomous resistance pathways in Legionella pneumophila infection.
Int J Med Microbiol. 2017 Oct 27. pii: S1438-4221(17)30306-5.
Opitz B
Inflammasome Deficiency Makes Pro-resolving Lipid Mediators Great Again.
Am J Respir Crit Care Med. 2017;196:668-669
Seeberger PH, Pereira CL, Khan N, Xiao G, Diago-Navarro E, Reppe K, Opitz B, Fries BC, Witzenrath M
A semi-synthetic glycoconjugate vaccine candidate for carbapenem-resistant Klebsiella pneumoniae.
Angew Chem Int Ed Engl. 2017 Aug 16
Patel S, Blaauboer SM, Tucker HR, Mansouri S, Ruiz-Moreno JS, Hamann L, Schumann RR, Opitz B, Jin L
The Common R71H-G230A-R293Q Human TMEM173 Is a Null Allele.
J Immunol December 7, 2016, 1601585
http://www.jimmunol.org/content/early/2016/12/07/jimmunol.1601585.abstract
Kostadinova E, Chaput C, Gutbier B, Lippmann J, Sander LE, Mitchell TJ, Suttorp N, Witzenrath M, Opitz B
NLRP3 protects alveolar barrier integrity by an inflammasome-independent increase of epithelial cell adherence
Sci Rep. 2016 Aug 1;6:30943
Rabes A, Suttorp N, Opitz B
Inflammasomes in Pneumococcal Infection: Innate Immune Sensing and Bacterial Evasion Strategies.
Curr Top Microbiol Immunol. 2016;397:215-27
Tabeling C, Noe E, Naujoks J, Doehn JM, Hippenstiel S, Opitz B, Suttorp N, Klopfleisch R, Witzenrath M
PKCα Deficiency in Mice Is Associated with Pulmonary Vascular Hyperresponsiveness to Thromboxane A2 and Increased Thromboxane Receptor Expression.
J Vasc Res. 2015;52(4):279-88
Naujoks J, Tabeling C, Dill BD, Hoffmann C, Brown AS, Kunze M, Kempa S, Peter A, Mollenkopf HJ, Dorhoi A, Kershaw O, Gruber AD, Sander LE, Witzenrath M, Herold S, Nerlich A, Hocke AC, van Driel I, Suttorp N, Bedoui S, Hilbi H, Trost M, Opitz B
IFNs Modify the Proteome of Legionella-Containing Vacuoles and Restrict Infection Via IRG1-Derived Itaconic Acid.
PLoS Pathog. 2016 Feb 1;12(2)
Fatykhova D, Rabes A, Machnik C, Guruprasad K, Pache F, Berg J, Toennies M, Bauer TT, Schneider P, Schimek M, Eggeling S, Mitchell TJ, Mitchell AM, Hilker R, Hain T, Suttorp N, Hippenstiel S, Hocke AC, Opitz B
Serotype 1 and 8 Pneumococci Evade Sensing by Inflammasomes in Human Lung Tissue.
PLoS One. 2015 Aug 28;10(8):e0137108
Müller-Redetzky HC, Wienhold SM, Berg J, Hocke AC, Hippenstiel S, Hellwig K, Gutbier B, Opitz B, Neudecker J, Rückert J, Gruber AC, Kershaw O, Mayer K, Suttorp N, Witzenrath M
Moxifloxacin is not anti-inflammatory in experimental pneumococcal pneumonia.
J Antimicrob Chemother. 2015 Mar;70(3):830-40
Rabes A, Zimmermann S, Reppe K, Lang R, Seeberger PH, Suttorp N, Witzenrath M, Lepenies B, Opitz B
The C-type lectin receptor Mincle binds to Streptococcus pneumoniae but plays a limited role in the anti-pneumococcal innate immune response.
PLoS One. 2015 Feb 6;10(2):e0117022
Müller-Redetzky HC, Felten M, Hellwig K, Wienhold SM, Naujoks J, Opitz B, Kershaw O, Gruber AD, Suttorp N, Witzenrath M
Increasing the inspiratory time and I:E ratio during mechanical ventilation aggravates ventilator-induced lung injury in mice.
Critical Care 2015, 19:23
Noe E, Tabeling C, Doehn JM, Naujoks J, Opitz B, Hippenstiel S, Witzenrath M, Klopfleisch R
Juvenile megaesophagus in PKCα-deficient mice is associated with an increase in the segment of the distal esophagus lined by smooth muscle cells.
Ann Anat. 2014 Sep;196(5):365-71
Tabeling C, Scheer H, Schönrock SM, Runge F, Gutbier B, Lienau J, Hamelmann E, Opitz B, Suttorp N, Mayer K, Behrens GM, Tschernig T, Witzenrath M
Nucleotide oligomerization domain 1 ligation suppressed murine allergen-specific T-cell proliferation and airway hyperresponsiveness.
Am J Respir Cell Mol Biol. 2014 May;50(5):903-11
Tabeling C, Scheer H, Schönrock SM, Runge F, Gutbier B, Lienau J, Hamelmann E, Opitz B, Suttorp N, Mayer K, Behrens GM, Tschernig T, Witzenrath M.
NOD1 Ligation Suppressed Murine Allergen-Specific T Cell Proliferation and Airway Hyperresponsiveness.
Am J Respir Cell Mol Biol. 2013 Nov 26.
Naujoks J, Opitz B
Bacterial infections and the DNA sensing pathway
Bookchapter DNA Sensing: The impact of dsDNA on Disease and Vaccinology. Edited by Ken Ishii and Jason C.K. Tang; Elsevier
http://store.elsevier.com/Biological-DNA-Sensor/isbn-9780124047327
Chaput C, Sander LE, Suttorp N, Opitz B
NOD-Like Receptors in Lung Diseases.
Front Immunol. 2013, 4, 393.
Helbig ET, Opitz B, Sander LE
Adjuvant immunotherapies as a novel approach to bacterial infections
Immunotherapy. 2013;5, 365-81.
Yu P, Lübben W, Slomka H, Gebler J, Konert M, Cai C, Neubrandt L, Prazeres da Costa O, Paul S, Dehnert S, Döhne K, Thanisch M, Storsberg S, Wiegand L, Kaufmann A, Nain M, Quintanilla-Martinez L, Bettio S, Schnierle B, Kolesnikova L, Becker S, Schnare M,
Nucleic acid-sensing Toll-like receptors are essential for the control of endogenous retrovirus viremia and ERV-induced tumors
Immunity. 2012 Nov 16;37(5):867-79. doi: 10.1016/j.immuni.2012.07.018.
Koppe U, Suttorp N, Opitz B
Recognition of Streptococcus pneumoniae by the innate immune system.
Cell Microbiol. 2012 Apr;14(4):460-6. doi: 10.1111/j.1462-5822.2011.01746.x. Epub 2012 Feb 8
Jöckel S, Nees G, Sommer R, Zhao Y, Cherkasov D, Hori H, Ehm G, Schnare M, Nain M, Kaufmann A, Bauer S
The 2´-O-methylation status of a single guanosine controls transfer RNA-mediated Toll-like receptor 7 activation or inhibition
J Exp Med. 2012 Feb 13;209(2):235-41. Epub 2012 Feb 6.
Eitel J, Meixenberger K, van Laak C, Orlovski C, Hocke A, Schmeck B, Hippenstiel S, N’Guessan PD, Suttorp N, Opitz B
Rac1 regulates the NLRP3 inflammasome which mediates IL-1beta production in Chlamydophila pneumoniae infected human mononuclear cells.
PLoS One. 2012;7(1):e30379. doi: 10.1371/journal.pone.0030379. Epub 2012 Jan 20.
Koppe U, Högner K, Witzenrath M, Bauer S, Hammerschmidt S, Suttorp N, Herold S, Opitz B.
Streptococcus pneumoniae stimulates a STING- and IFN regulatory factor 3-dependent type I IFN production in macrophages, which regulates RANTES production in macrophages, cocultured alveolar epithelial cells, and mouse lungs.
J Immunol. 2012 Jan 15;188(2):811-7
Lippmann J, Müller H, Naujoks J, Tabeling C, Shin S, Witzenrath M, Hellwig K, Kirschning CJ, Taylor GA, Barchet W, Bauer S, Suttorp N, Roy CR, Opitz B
Dissection of a type I interferon pathway in controlling bacterial intracellular infection in mice.
Cell Microbiol. 2011 Nov;13(11):1668-82. doi: 10.1111/j.1462-5822.2011.01646.x. Epub 2011 Aug 24
Witzenrath M, Pache F, Lorenz D, Koppe U, Schönrock S, Meixenberger K, Dorhoi A, Ma J, Holmes A, Trendelenburg G, Heimesaat MM, Bereswill S, van der Linden M, Tschopp J, Mitchell TJ, Suttorp N, Opitz B.
The NLRP3 Inflammasome is Differentially Activated by Pneumolysin Variants and Contributes to Host Defense in Pneumococcal Pneumonia.
J Immunol. 2011 Jul 1;187(1):434-40. Epub 2011 Jun 6.
Eitel J, Suttorp N, Opitz B.
Innate immune recognition and inflammasome activation in Listeria monocytogenes infection.
Front Microbiol. 2011;1: 149
Lorenz J, Zahlten J, Pollok I, Lippmann J, Scharf S, N´Guessan PD, Opitz B, Flieger A, Suttorp N, Hippenstiel S, Schmeck B.
Legionella pneumophila-induced I?B?-dependent expression of interleukin-6 in lung epithelium.
Eur Respir J. 2011 Mar;37(3):648-57. Epub 2010 Jul 22.
Scharf S, Vardarova K, Lang F, Schmeck B, Opitz B, Flieger A, Heuner K, Hippenstiel S, Suttorp N, N´Guessan PD.
Legionella pneumophila induces human beta defensin-3 in pulmonary cells.
Respir Res. 2010 Jul 8;11:93.
Ryan TAJ, Hooftman A, Rehill AM, Johansen MD, Brien ECO, Toller-Kawahisa JE, Wilk MM, Day EA, Weiss HJ, Sarvari P, Vozza EG, Schramm F, Peace CG, Zotta A, Miemczyk S, Nalkurthi C, Hansbro NG, McManus G, O'Doherty L, Gargan S, Long A, Dunne J, Cheallaigh CN, Conlon N, Carty M, Fallon PG, Mills KHG, Creagh EM, Donnell JSO, Hertzog PJ, Hansbro PM, McLoughlin RM, Wygrecka M, Preston RJS, Zasłona Z, Neill LAJO.
Dimethyl fumarate and 4-octyl itaconate are anticoagulants that suppress Tissue Factor in macrophages via inhibition of Type I Interferon.
Nat Commun. 2023 Jun 14;14(1):3513. doi: 10.1038/s41467-023-39174-1. https://pubmed.ncbi.nlm.nih.gov/37316487/
Asmus E, Karle W, Brack MC, Wittig C, Behrens F, Reinshagen L, Pfeiffer M, Schulz S, Mandzimba-Maloko B, Erfinanda L, Perret PL, Michalick L, Smeele PJ, Lim EHT, van den Brom CE, Vonk ABA, Kaiser T, Suttorp N, Hippenstiel S, Sander LE, Kurth F, Rauch U, Landmesser U, Haghikia A, Preissner R, Bogaard HJ, Witzenrath M, Kuebler WM, Szulcek R, Simmons S.
Cystic fibrosis transmembrane conductance regulator modulators attenuate platelet activation and aggregation in blood of healthy donors and COVID-19 patients.
Eur Respir J. 2023 Mar 23;61(3):2202009. doi: 10.1183/13993003.02009-2022. Print 2023 Mar.PMID: 36958745 https://pubmed.ncbi.nlm.nih.gov/36958745/
Sauer A, Seeliger B, Jandl K, Erfinanda L, Wilhelm J, Alexopoulos I, Baal N, Birnhuber A, David S, Welte T, Barreto G, Gaertner U, Kwapiszewska G, Seeger W, Kuebler WM, Schaefer L, Wygrecka M; members of the CAPNETZ Study Group.
Circulating hyaluronic acid signature in CAP and ARDS - the role of pneumolysin in hyaluronic acid shedding
Matrix Biol. 2022 Dec;114:67-83. doi: 10.1016/j.matbio.2022.11.003. Epub 2022 Nov 16. https://pubmed.ncbi.nlm.nih.gov/36456058/
Pennitz P, Kirsten H, Friedrich VD, Wyler E, Goekeri C, Obermayer B, Heinz GA, Mashreghi MF, Büttner M, Trimpert J, Landthaler M, Suttorp N, Hocke AC, Hippenstiel S, Tönnies M, Scholz M, Kuebler WM, Witzenrath M, Hoenzke K, Nouailles G.
A pulmonologist's guide to perform and analyse cross-species single lung cell transcriptomics
Eur Respir Rev. 2022 Jul 27;31(165):220056. doi: 10.1183/16000617.0056-2022. https://pubmed.ncbi.nlm.nih.gov/35896273/
Wyler E, Adler JM, Eschke K, Teixeira Alves G, Peidli S, Pott F, Kazmierski J, Michalick L, Kershaw O, Bushe J, Andreotti S, Pennitz P, Abdelgawad A, Postmus D, Goffinet C, Kreye J, Reincke SM, Prüss H, Blüthgen N, Gruber AD, Kuebler WM, Witzenrath M, Landthaler M, Nouailles G, Trimpert J.
Key benefits of dexamethasone and antibody treatment in COVID-19 hamster models revealed by single-cell transcriptomics
Mol Ther. 2022 May 4;30(5):1952-1965. doi: 10.1016/j.ymthe.2022.03.014. Epub 2022 Mar 24. https://pubmed.ncbi.nlm.nih.gov/35339689/
Wygrecka M, Birnhuber A, Seeliger B, Michalick L, Pak O, Schultz AS, Schramm F, Zacharias M, Gorkiewicz G, David S, Welte T, Schmidt JJ, Weissmann N, Schermuly RT, Barreto G, Schaefer L, Markart P, Brack MC, Hippenstiel S, Kurth F, Sander LE, Witzenrath M, Kuebler WM, Kwapiszewska G, Preissner KT.
Altered fibrin clot structure and dysregulated fibrinolysis contribute to thrombosis risk in severe COVID-19
Blood Adv. 2022 Feb 8;6(3):1074-1087. doi: 10.1182/bloodadvances.2021004816. pubmed.ncbi.nlm.nih.gov/34861681/
Georg P, Astaburuaga-García R, Bonaguro L, Brumhard S, Michalick L, Lippert LJ, Kostevc T, Gäbel C, Schneider M, Streitz M, Demichev V, Gemünd I, Barone M, Tober-Lau P, Helbig ET, Hillus D, Petrov L, Stein J, Dey HP, Paclik D, Iwert C, Mülleder M, Aulakh SK, Djudjaj S, Bülow RD, Mei HE, Schulz AR, Thiel A, Hippenstiel S, Saliba AE, Eils R, Lehmann I, Mall MA, Stricker S, Röhmel J, Corman VM, Beule D, Wyler E, Landthaler M, Obermayer B, von Stillfried S, Boor P, Demir M, Wesselmann H, Suttorp N, Uhrig A, Müller-Redetzky H, Nattermann J, Kuebler WM, Meisel C, Ralser M, Schultze JL, Aschenbrenner AC, Thibeault C, Kurth F, Sander LE, Blüthgen N, Sawitzki B; PA-COVID-19 Study Group.
Complement activation induces excessive T cell cytotoxicity in severe COVID-19
Cell. 2022 Feb 3;185(3):493-512.e25. doi: 10.1016/j.cell.2021.12.040. Epub 2021 Dec 28. pubmed.ncbi.nlm.nih.gov/35032429/
Ehrlich K, Wilhelm J, Markart P, Weisser H, Wolff JC, Bein G, Pak O, Barreto G, Weissmann N, Schramm F, Seeger W, Schaefer L, Kuebler WM, Wygrecka M; and members of the CAPNETZ Study Group.
Sex-specific differences in plasma levels of FXII, HK, and FXIIa-C1-esterase inhibitor complexes in community-acquired pneumonia.
Am J Physiol Lung Cell Mol Physiol. 2021 Oct 1;321(4):L764-L774. doi: 10.1152/ajplung.00162.2021. Epub 2021 Jul 28. PMID: 34318685. pubmed.ncbi.nlm.nih.gov/34318685/
Brox R, Achenbach S, Hackstein H.
Detection of SARS-CoV-2-independent immunoregulatory activity of COVID-19 convalescent plasma.
Transfusion. 2021 Sep 21. doi: 10.1111/trf.16685. Epub ahead of print. PMID: 34546583. pubmed.ncbi.nlm.nih.gov/34546583/
Pusch L, Brox R, Scheuer K, Yokosawa T, Wu M, Zubiri BA, Spiecker E, Jandt KD, Fischer D, Hackstein H.
Distinct endocytosis and immune activation of poly(lactic-co-glycolic) acid nanoparticles prepared by single- and double-emulsion evaporation.
Nanomedicine (Lond). 2021 Oct;16(23):2075-2094. doi: 10.2217/nnm-2021-0022. Epub 2021 Sep 15. PMID: 34523349. pubmed.ncbi.nlm.nih.gov/34523349/
Birnhuber A, Fliesser E, Gorkiewicz G, Zacharias M, Seeliger B, David S, Welte T, Schmidt J, Olschewski H, Wygrecka M, Kwapiszewska G.
Between inflammation and thrombosis - endothelial cells in COVID-19
Eur Respir J. 2021 May 13:2100377. doi: 10.1183/13993003.00377-2021. Epub ahead of print. PMID: 33958433; PMCID: PMC8112008. pubmed.ncbi.nlm.nih.gov/33958433/
Cunningham S, Hackstein H.
Rapid generation of monocyte-derived antigen-presenting cells with dendritic cell-like properties.
Transfusion. 2021 Jun;61(6):1845-1855. doi: 10.1111/trf.16385. Epub 2021 Mar 30. PMID: 33786883. pubmed.ncbi.nlm.nih.gov/33786883/
Messner CB, Demichev V, Wendisch D, Michalick L, White M, Freiwald A, Textoris-Taube K, Vernardis SI, Egger AS, Kreidl M, Ludwig D, Kilian C, Agostini F, Zelezniak A, Thibeault C, Pfeiffer M, Hippenstiel S, Hocke A, von Kalle C, Campbell A, Hayward C, Porteous DJ, Marioni RE, Langenberg C, Lilley KS, Kuebler WM, Mülleder M, Drosten C, Suttorp N, Witzenrath M, Kurth F, Sander LE, Ralser M
Ultra-High-Throughput Clinical Proteomics Reveals Classifiers of COVID-19 Infection
Lippitsch A, Baal N, Chukovetskyi Y, Cunningham S, Michel G, Dietert K, Gurtner C, Gruber AD, Bein G, Hackstein H
Plasmacytoid dendritic cell depletion modifies FoxP3+ T cell homeostasis and the clinical course of bacterial pneumonia in mice.
J Leukoc Biol. 2019 Jul 2
Didiasova M, Zakrzewicz D, Schaefer L, Wygrecka M
When Place Matters: Shuttling of Enolase-1 Across Cellular Compartments.
Front Cell Dev Biol. 2019 Apr 26;7:61
Baal N, Cunningham S, Obermann HL, Thomas J, Lippitsch A, Dietert K, Gruber AD, Kaufmann A, Michel G, Nist A, Stiewe T, Rupp O, Goesmann A, Zukunft S, Fleming I, Bein G, Lohmeyer J, Bauer S, Hackstein H
ADAR1 Is Required for Dendritic Cell Subset Homeostasis and Alveolar Macrophage Function.
J Immunol. 2019 Feb 15;202(4):1099-1111
Didiasova M, Wujak L, Schaefer L, Wygrecka M.
Factor XII in coagulation, inflammation and beyond.
Zakrzewicz D, Didiasova M, Krüger M, Giaimo BD, Borggrefe T, Mieth M, Hocke AC, Zakrzewicz A, Schaefer L, Preissner KT, Wygrecka M
Protein arginine methyltransferase 5 mediates enolase-1 cell surface trafficking in human lung adenocarcinoma cells.
Biochim Biophys Acta. 2018 May;1864(5 Pt A):1816-1827
Hess R, Wujak L, Hesse C, Sewald K, Jonigk D, Warnecke G, Fieguth HG, de Maat S, Maas C, Bonella F, Preissner KT, Weiss B, Schaefer L, Kuebler WM, Markart P, Wygrecka M
Coagulation factor XII regulates inflammatory responses in human lungs.
Thromb Haemost. 2017 Oct 5;117(10):1896-1907
Wygrecka M, Kosanovic D, Wujak L, Reppe K, Henneke I, Frey H, Didiasova M, Kwapiszewska G, Marsh LM, Baal N, Hackstein H, Zakrzewicz D, Müller-Redetzky HC, de Maat S, Maas C, Nolte MW, Panousis C, Schermuly RT, Seeger W, Witzenrath M, Schaefer L, Markart
Antihistone Properties of C1 Esterase Inhibitor Protect against Lung Injury.
Am J Respir Crit Care Med. 2017 Jul 15;196(2):186-199
Zakrzewicz D, Bergmann S, Didiasova M, Giaimo BD, Borggrefe T, Mieth M, Hocke AC, Lochnit G, Schaefer L, Hammerschmidt S, Preissner KT, Wygrecka M
Host-derived extracellular RNA promotes adhesion of Streptococcus pneumoniae to endothelial and epithelial cells.
Sci Rep. 2016 Nov 28;6:37758
Didiasova M, Zakrzewicz D, Magdolen V, Nagaraj C, Bálint Z, Rohde M, Preissner KT, Wygrecka M
STIM1/ORAI1-mediated Ca2+ Influx Regulates Enolase-1 Exteriorization.
J Biol Chem. 2015 May 8;290(19):11983-99
Zakrzewicz D, Didiasova M, Zakrzewicz A, Hocke AC, Uhle F, Markart P, Preissner KT, Wygrecka M
The interaction of enolase-1 with caveolae-associated proteins regulates its subcellular localization.
Biochem J. 2014 Jun 1;460(2):295-307
Zakrzewicz D, Zakrzewicz A, Preissner KT, Markart P, Wygrecka M
Protein Arginine Methyltransferases (PRMTs): Promising Targets for the Treatment of Pulmonary Disorders.
Int J Mol Sci. 2012, 13, 12383-400
Wygrecka M, Wilhelm J, Jablonska E, Zakrzewicz D, Preissner KT, Seeger W, Guenther A, Markart P
Shedding of Low Density Lipoprotein Receptor-related Protein-1 in Acute Respiratory Distress Syndrome
Am J Respir Crit Care Med. 2011 Aug 15;184(4):438-48. doi: 10.1164/rccm.201009-1422OC. PMID: 21471105. pubmed.ncbi.nlm.nih.gov/21471105/
Romero MJ, Yue Q, Singla B, Hamacher J, Sridhar S, Moseley AS, Song C, Mraheil MA, Fischer B, Zeitlinger M, Chakraborty T, Fulton D, Gan L, Annex BH, Csanyi G, Eaton DC, Lucas R.
Direct endothelial ENaC activation mitigates vasculopathy induced by SARS-CoV2 spike protein
Front Immunol 2023 Aug 10;14:1241448. doi: 10.3389/fimmu.2023.1241448. eCollection 2023. https://pubmed.ncbi.nlm.nih.gov/37638055/
Baiomy AA, Serry FE, Kadry AA, Yahya G, Doijad S, Mostafa A, Mraheil MA, El-Ganiny AM
Genome Analysis of Pseudomonas aeruginosa Strains from Chronically Infected Patients with High Levels of Persister Formation
Pathogen 2023 Mar 8;12(3):426.
doi: 10.3390/pathogens12030426. https://pubmed.ncbi.nlm.nih.gov/36986348/
Al-Karmalawy AA, Soltane R, Abo Elmaaty A, Tantawy MA, Antar SA, Yahya G, Chrouda A, Pashameah RA, Mustafa M, Abu Mraheil M, Mostafa A.
Coronavirus Disease (COVID-19) Control between Drug Repurposing and Vaccination: A Comprehensive Overview
Vaccines (Basel). 2021 Nov 12;9(11):
doi: 10.3390/vaccines9111317. https://pubmed.ncbi.nlm.nih.gov/34835248/
Hegazy A, Mostafa I, Elshaier YAMM, Mahmoud SH, Abo Shama NM, Shehata M, Yahya G, Nasr NF, El-Halawany AM, Ali MA, Ali MA, Mraheil MA, El-Shazly AM, Mostafa A
Robust Antiviral Activity of Santonica Flower Extract (Artemisia cina) against Avian and Human Influenza A Viruses: In Vitro and Chemoinformatic Studies.
ACS Omega 2022 Nov 2;7(45):41212-41223. doi: 10.1021/acsomega.2c04867. eCollection 2022 Nov 15. https://pubmed.ncbi.nlm.nih.gov/36406485/
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SecA2 Associates with Translating Ribosomes and Contributes to the Secretion of Potent IFN-β Inducing RNAs
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Altered fibrin clot structure and dysregulated fibrinolysis contribute to thrombosis risk in severe COVID-19
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The secRNome of Listeria monocytogenes Harbors Small Noncoding RNAs That Are Potent Inducers of Beta Interferon.
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RhoA S-nitrosylation as a regulatory mechanism influencing endothelial barrier function in response to G+-bacterial toxins.
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The Lectin-like Domain of TNF Increases ENaC Open Probability through a Novel Site at the Interface between the Second Transmembrane and C-terminal Domains of the α-Subunit.
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