Transregio SFB-TR 84 “Innate Immunity of the Lung: Mechanisms of Pathogen Attack and Host Defence in Pneumonia“



Ehrlich K, Wilhelm J, Markart P, Weisser H, Wolff JC, Bein G, Pak O, Barreto G, Weissmann N, Schramm F, Seeger W, Schaefer L, Kuebler WM, Wygrecka M; and members of the CAPNETZ Study Group.

Sex-specific differences in plasma levels of FXII, HK, and FXIIa-C1-esterase inhibitor complexes in community-acquired pneumonia.

Am J Physiol Lung Cell Mol Physiol. 2021 Oct 1;321(4):L764-L774. doi: 10.1152/ajplung.00162.2021. Epub 2021 Jul 28. PMID: 34318685.

Brox R, Achenbach S, Hackstein H.

Detection of SARS-CoV-2-independent immunoregulatory activity of COVID-19 convalescent plasma.

Transfusion. 2021 Sep 21. doi: 10.1111/trf.16685. Epub ahead of print. PMID: 34546583.

Pusch L, Brox R, Scheuer K, Yokosawa T, Wu M, Zubiri BA, Spiecker E, Jandt KD, Fischer D, Hackstein H.

Distinct endocytosis and immune activation of poly(lactic-co-glycolic) acid nanoparticles prepared by single- and double-emulsion evaporation.

Nanomedicine (Lond). 2021 Oct;16(23):2075-2094. doi: 10.2217/nnm-2021-0022. Epub 2021 Sep 15. PMID: 34523349.

Ehrlich K, Wilhelm J, Markart P, Weisser H, Wolff JC, Bein G, Pak O, Barreto G, Weissmann N, Schramm F, Seeger W, Schaefer L, Kuebler WM, Wygrecka M; CAPNETZ Study Group.

Sex-specific differences in plasma levels of FXII, HK, and FXIIa-C1-esterase inhibitor complexes in community acquired pneumonia.

Am J Physiol Lung Cell Mol Physiol. 2021 Jul 28. doi: 10.1152/ajplung.00162.2021. Epub ahead of print. PMID: 34318685.

Birnhuber A, Fliesser E, Gorkiewicz G, Zacharias M, Seeliger B, David S, Welte T, Schmidt J, Olschewski H, Wygrecka M, Kwapiszewska G.

Between inflammation and thrombosis - endothelial cells in COVID-19

Eur Respir J. 2021 May 13:2100377. doi: 10.1183/13993003.00377-2021. Epub ahead of print. PMID: 33958433; PMCID: PMC8112008.

Cunningham S, Hackstein H.

Rapid generation of monocyte-derived antigen-presenting cells with dendritic cell-like properties.

Transfusion. 2021 Jun;61(6):1845-1855. doi: 10.1111/trf.16385. Epub 2021 Mar 30. PMID: 33786883.

Messner CB, Demichev V, Wendisch D, Michalick L, White M, Freiwald A, Textoris-Taube K, Vernardis SI, Egger AS, Kreidl M, Ludwig D, Kilian C, Agostini F, Zelezniak A, Thibeault C, Pfeiffer M, Hippenstiel S, Hocke A, von Kalle C, Campbell A, Hayward C, Porteous DJ, Marioni RE, Langenberg C, Lilley KS, Kuebler WM, Mülleder M, Drosten C, Suttorp N, Witzenrath M, Kurth F, Sander LE, Ralser M

Ultra-High-Throughput Clinical Proteomics Reveals Classifiers of COVID-19 Infection

Cell Syst. 2020 Jul 22;11(1):11-24.e4.

Kuebler W, Jordt SE, Liedtke WB

Urgent reconsideration of lung edema as a preventable outcome in COVID-19: inhibition of TRPV4 represents a promising and feasible approach

Am J Physiol Lung Cell Mol Physiol. 2020 Jun 1;318(6):L1239-L1243

Walther T, Kuebler WM

Don't judge too RAShly: the multifaceted role of the renin-angiotensin system and its therapeutic potential in COVID-19.

Am J Physiol Lung Cell Mol Physiol. 2020 May 1;318(5):L1023-L1024.

Lippitsch A, Baal N, Chukovetskyi Y, Cunningham S, Michel G, Dietert K, Gurtner C, Gruber AD, Bein G, Hackstein H

Plasmacytoid dendritic cell depletion modifies FoxP3+ T cell homeostasis and the clinical course of bacterial pneumonia in mice.

J Leukoc Biol. 2019 Jul 2

Didiasova M, Zakrzewicz D, Schaefer L, Wygrecka M

When Place Matters: Shuttling of Enolase-1 Across Cellular Compartments.

Front Cell Dev Biol. 2019 Apr 26;7:61

Baal N, Cunningham S, Obermann HL, Thomas J, Lippitsch A, Dietert K, Gruber AD, Kaufmann A, Michel G, Nist A, Stiewe T, Rupp O, Goesmann A, Zukunft S, Fleming I, Bein G, Lohmeyer J, Bauer S, Hackstein H

ADAR1 Is Required for Dendritic Cell Subset Homeostasis and Alveolar Macrophage Function.

J Immunol. 2019 Feb 15;202(4):1099-1111

Didiasova M, Wujak L, Schaefer L, Wygrecka M.

Factor XII in coagulation, inflammation and beyond.

Cell Signal. 2018 Nov;51:257-265.

Zakrzewicz D, Didiasova M, Krüger M, Giaimo BD, Borggrefe T, Mieth M, Hocke AC, Zakrzewicz A, Schaefer L, Preissner KT, Wygrecka M

Protein arginine methyltransferase 5 mediates enolase-1 cell surface trafficking in human lung adenocarcinoma cells.

Biochim Biophys Acta. 2018 May;1864(5 Pt A):1816-1827

Frevert CW, Felgenhauer J, Wygrecka M, Nastase MV, Schaefer L.

Danger-Associated Molecular Patterns Derived From the Extracellular Matrix Provide Temporal Control of Innate Immunity.

Danger-Associated Molecular Patterns Derived From the Extracellular Matrix Provide Temporal Control of Innate Immunity

Hess R, Wujak L, Hesse C, Sewald K, Jonigk D, Warnecke G, Fieguth HG, de Maat S, Maas C, Bonella F, Preissner KT, Weiss B, Schaefer L, Kuebler WM, Markart P, Wygrecka M

Coagulation factor XII regulates inflammatory responses in human lungs.

Thromb Haemost. 2017 Oct 5;117(10):1896-1907

Wygrecka M, Kosanovic D, Wujak L, Reppe K, Henneke I, Frey H, Didiasova M, Kwapiszewska G, Marsh LM, Baal N, Hackstein H, Zakrzewicz D, Müller-Redetzky HC, de Maat S, Maas C, Nolte MW, Panousis C, Schermuly RT, Seeger W, Witzenrath M, Schaefer L, Markart

Antihistone Properties of C1 Esterase Inhibitor Protect against Lung Injury.

Am J Respir Crit Care Med. 2017 Jul 15;196(2):186-199

Zakrzewicz D, Bergmann S, Didiasova M, Giaimo BD, Borggrefe T, Mieth M, Hocke AC, Lochnit G, Schaefer L, Hammerschmidt S, Preissner KT, Wygrecka M

Host-derived extracellular RNA promotes adhesion of Streptococcus pneumoniae to endothelial and epithelial cells.

Sci Rep. 2016 Nov 28;6:37758

Garn H, Bahn S, Baune BT, Binder EB, Bisgaard H, Chatila TA, Chavakis T, Culmsee C, Dannlowski U, Gay S, Gern J, Haahtela T, Kircher T, Müller-Ladner U, Neurath MF, Preissner KT, Reinhardt C, Rook G, Russell S, Schmeck B, Stappenbeck T, Steinhoff U, van

Current concepts in chronic inflammatory diseases: Interactions between microbes, cellular metabolism, and inflammation.

J Allergy Clin Immunol. 2016 Jul;138(1):47-56

Didiasova M, Zakrzewicz D, Magdolen V, Nagaraj C, Bálint Z, Rohde M, Preissner KT, Wygrecka M

STIM1/ORAI1-mediated Ca2+ Influx Regulates Enolase-1 Exteriorization.

J Biol Chem. 2015 May 8;290(19):11983-99

Wujak L, Didiasova M, Zakrzewicz D, Frey H, Schaefer L, Wygrecka M

Heparan sulfate proteoglycans mediate factor XIIa binding to the cell surface.

J Biol Chem. 2015 Mar 13;290(11):7027-39

Cabrera-Fuentes HA, Lopez ML, McCurdy S, Fischer S, Meiler S, Baumer Y, Galuska SP, Preissner KT, Boisvert WA

Regulation of monocyte/macrophage polarisation by extracellular RNA.

Thromb Haemost. 2015 Mar;113(3):473-81

Saffarzadeh M, Preissner KT

Moonlighting proteins dictate the crosstalk between thrombosis and innate immunity.

J Thromb Haemost. 2014 Dec;12(12):2070-3

Zakrzewicz D, Didiasova M, Zakrzewicz A, Hocke AC, Uhle F, Markart P, Preissner KT, Wygrecka M

The interaction of enolase-1 with caveolae-associated proteins regulates its subcellular localization.

Biochem J. 2014 Jun 1;460(2):295-307

Peters DM, Vadász I, Wujak L, Wygrecka M, Olschewski A, Becker C, Herold S, Papp

TGF-ß directs trafficking of the epithelial sodium channel ENaC which has implications for ion and fluid transport in acute lung injury.

Proc Natl Acad Sci U S A. 2014 Jan 21;111(3):E374-83

Mukhametshina RT, Ruhs A, Singh I, Hasan D, Contreras A, Mehta A, Nikam VS, Ahlbrecht K, Carraro G, Cabrera-Fuentes HA, Jiang D, Voswinckel R, Seeger W, Bellusci S, Scharffetter-Kochanek K, Bagaeva TV, Preissner KT, Boettger T, Braun T, Krüger M, Barreto

Quantitative Proteome Analysis of Alveolar Type-II Cells Reveals a Connection of Integrin Receptor Subunits Beta 2/6 and WNT Signaling.

J Proteome Res. 2013 Dec 6;12(12):5598-608. doi: 10.1021/pr400573k. Epub 2013 Nov 18.

Fulde M, Bernardo-García N, Rohde M, Nachtigall N, Frank R, Preissner KT, Klett J, Morreale A, Chhatwal GS, Hermoso JA, Bergmann S.

Pneumococcal phosphoglycerate kinase interacts with plasminogen and its tissue activator.

Thromb Haemost. 2013 Nov 7;111(3). [Epub ahead of print]

Jaax ME, Krauel K, Marschall T, Brandt S, Gansler J, Fürll B, Appel B, Fischer S, Block S, Helm CA, Müller S, Preissner KT, Greinacher A

Complex formation with nucleic acids and aptamers alters the antigenic properties of platelet factor 4

Blood. 2013, 122, 272-81

Ulm C, Saffarzadeh M, Mahavadi P, Müller S, Prem G, Saboor F, Simon P, Middendorff R, Geyer H, Henneke I, Bayer N, Rinné S, Lütteke T, Böttcher-Friebertshäuser E, Gerardy-Schahn R, Schwarzer D, Mühlenhoff M, Preissner KT, Günther A, Geyer R, Galusk

Soluble polysialylated NCAM: a novel player of the innate immune system in the lung

Cell Mol Life Sci. 2013 Oct;70(19):3695-708. doi: 10.1007/s00018-013-1342-0. Epub 2013 Apr 26

Saffarzadeh, M. and Preissner, K.T.,

Fighting against the dark side of neutrophil extracellular traps in disease: manoeuvres for host protection.

Curr Opin Hematol. 2013, 20, 3-9.

Fischer, S. and Preissner, K.T.,

Extracellular nucleic acids as novel alarm signals in the vascular system. Mediators of defence and disease.

Hamostaseologie. 2013, 33, 37-42.

Gansler J, Jaax M, Leiting S, Appel B, Greinacher A, Fischer S, Preissner KT

Structural requirements for the procoagulant activity of nucleic acids

PLoS One. 2012, 7, e50399. Epub 2012 Nov 30

Zakrzewicz D, Zakrzewicz A, Preissner KT, Markart P, Wygrecka M

Protein Arginine Methyltransferases (PRMTs): Promising Targets for the Treatment of Pulmonary Disorders.

Int J Mol Sci. 2012, 13, 12383-400

Fischer S, Grantzow T, Pagel JI, Tschernatsch M, Sperandio M, Preissner KT, Deindl E

Extracellular RNA promotes leukocyte recruitment in the vascular system by mobilising proinflammatory cytokines

Thromb Haemost. 2012 Oct;108(4):730-41. Epub 2012 Jul 26.

Grommes J, Alard JE, Drechsler M, Wantha S, Mörgelin M, Kuebler WM, Jacobs M, von Hundelshausen P, Markart P, Wygrecka M, Preissner KT, Hackeng TM, Koenen RR, Weber C, Soehnlein O

Disruption of platelet-derived chemokine heteromers prevents neutrophil extravasation in acute lung injury.

Am J Respir Crit Care Med. 2012 Mar 15;185(6):628-36

Saffarzadeh M, Juenemann C, Queisser MA, Lochnit G, Barreto G, Galuska SP, Lohmeyer J, Preissner KT

Neutrophil extracellular traps directly induce epithelial and endothelial cell death: a predominant role of histones

PLoS One. 2012, 7, e32366.

Wygrecka M, Wilhelm J, Jablonska E, Zakrzewicz D, Preissner KT, Seeger W, Guenther A, Markart P

Shedding of Low Density Lipoprotein Receptor-related Protein-1 in Acute Respiratory Distress Syndrome

Am J Respir Crit Care Med. 2011 Aug 15;184(4):438-48. doi: 10.1164/rccm.201009-1422OC. PMID: 21471105.

Fischer S, Nishio M, Dadkhahi S, Gansler J, Saffarzadeh M, Shibamiyama A, Kral N, Baal N, Koyama T, Deindl E, Preissner KT

Expression and localisation of vascular ribonucleases in endothelial cells

Thromb Haemost. 2011 Feb 1;105(2):345-55. Epub 2010 Nov 23.

Massberg S, Grahl L, von Bruehl ML, Manukyan D, Pfeiler S, Goosmann C, Brinkmann V, Lorenz M, Bidzhekov K, Khandagale AB, Konrad I, Kennerknecht E, Reges K, Holdenrieder S, Braun S, Reinhardt C, Spannagl M, Preissner KT, Engelmann B

Reciprocal coupling of coagulation and innate immunity via neutrophil serine proteases

Nat Med. 2010 Aug;16(8):887-96. Epub 2010 Aug 1.