Publications
Wee BA, Alves J, Lindsay DSJ, Klatt AB, Sargison FA, Cameron RL, Pickering A, Gorzynski J, Corander J, Marttinen P, Opitz B, Smith AJ, Fitzgerald JR.
Population analysis of Legionella pneumophila reveals a basis for resistance to complement-mediated killing
Nat Commun. 2021 Dec 9;12(1):7165. doi: 10.1038/s41467-021-27478-z. https://pubmed.ncbi.nlm.nih.gov/34887398/
Witkowski M, Tizian C, Ferreira-Gomes M, Niemeyer D, Jones TC, Heinrich F, Frischbutter S, Angermair S, Hohnstein T, Mattiola I, Nawrath P, Mc Ewen S, Zocche S, Viviano E, Heinz GA, Maurer M, Kölsch U, Chua RL, Aschman T, Meisel C, Radke J, Sawitzki B, Roehmel J, Allers K, Moos V, Schneider T, Hanitsch L, Mall MA, Conrad C, Radbruch H, Duerr CU, Trapani JA, Marcenaro E, Kallinich T, Corman VM, Kurth F, Sander LE, Drosten C, Treskatsch S, Durek P, Kruglov A, Radbruch A, Mashreghi MF, Diefenbach A.
Untimely TGFβ responses in COVID-19 limit antiviral functions of NK cells
Nature. 2021 Oct 25. doi: 10.1038/s41586-021-04142-6. Epub ahead of print. PMID: 34695836. pubmed.ncbi.nlm.nih.gov/34695836/
Scheuermann L, Pei G, Domaszewska T, Zyla J, Oberbeck-Müller D, Bandermann S, Feng Y, Ruiz Moreno JS, Opitz B, Mollenkopf HJ, Kaufmann SHE, Dorhoi A.
Platelets Restrict the Oxidative Burst in Phagocytes and Facilitate Primary Progressive Tuberculosis
Am J Respir Crit Care Med. 2020 Sep 1;202(5):730-744. doi: 10.1164/rccm.201910-2063OC. pubmed.ncbi.nlm.nih.gov/32421376/
Kurth F, Roennefarth M, Thibeault C, Corman VM, Müller-Redetzky H, Mittermaier M, Ruwwe-Glösenkamp C, Heim KM, Krannich A, Zvorc S, Schmidt S, Kretzler L, Dang-Heine C, Rose M, Hummel M, Hocke A, Hübner RH, Opitz B, Mall MA, Röhmel J, Landmesser U, Pieske B, Knauss S, Endres M, Spranger J, Mockenhaupt FP, Tacke F, Treskatsch S, Angermair S, Siegmund B, Spies C, Weber-Carstens S, Eckardt KU, Schürmann D, Uhrig A, Stegemann MS, Zoller T, Drosten C, Suttorp N, Witzenrath M, Hippenstiel S, von Kalle C, Sander LE.
Studying the pathophysiology of coronavirus disease 2019: a protocol for the Berlin prospective COVID-19 patient cohort (Pa-COVID-19).
Schaupp L, Muth S, Rogell L, Kofoed-Branzk M, Melchior F, Lienenklaus S, Ganal-Vonarburg SC, Klein M, Guendel F, Hain T, Schütze K, Grundmann U, Schmitt V, Dorsch M, Spanier J, Larsen PK, Schwanz T, Jäckel S, Reinhardt C, Bopp T, Danckwardt S, Mahnke K, Heinz GA, Mashreghi MF, Durek P, Kalinke U, Kretz O, Huber TB, Weiss S, Wilhelm C, Macpherson AJ, Schild H, Diefenbach A, Probst HC
Microbiota-Induced Type I Interferons Instruct a Poised Basal State of Dendritic Cells.
Wienhold SM, Macrì M, Nouailles G, Dietert K, Gurtner C, Gruber AD, Heimesaat MM, Lienau J, Schumacher F, Kleuser B, Opitz B, Suttorp N, Witzenrath M*, Müller-Redetzky HC*.
Ventilator-induced lung injury is aggravated by antibiotic mediated microbiota depletion in mice.
Crit Care. 2018;22(1):282. https://pubmed.ncbi.nlm.nih.gov/30373626/
Ugolini M, Gerhard J, Burkert S, Jensen KJ, Georg P, Ebner F, Thada S, Dietert K, Helbig ET, Opitz B, Kurth F, Dittrich N, Sumanlatha G, Blander JM, Gruber AD, Hartmann S, Boekschoten MV, Suttorp N, Müller M, Jungersen G, Schumann RR, Sander LE
Recognition of microbial viability via TLR8 promotes T follicular helper cell differentiation and vaccine responses.
Nat Immunol 2018
Ruiz-Moreno JS, Hamann L, Shah JA, Verbon A, Mockenhaupt FP, Puzianowska-Kuznicka M, Naujoks J, Sander LE, Witzenrath M, Cambier JC, Suttorp N, Schumann RR, Jin L, Hawn TR, Opitz B, CAPNETZ Study Group
The common HAQ STING variant impairs cGAS-dependent antibacterial responses and is associated with susceptibility to Legionnaires' disease in humans.
PLoS Pathog. 2018 Jan 3;14(1)
http://journals.plos.org/plospathogens/article?id=10.1371/journal.ppat.1006829
Ruiz-Moreno JS, Hamann L, Jin L, Sander LE, Puzianowska-Kuznickad M, Cambier JC, Witzenrath M, Schumann RR, Suttorp N, Opitz B, CAPNETZ Study Group
The cGAS/STING pathway detects Streptococcus pneumoniae but is dispensable for anti-pneumococcal defense in mice and humans.
Infect Immun. 2017 Dec 20. pii: IAI.00849-17
http://iai.asm.org/content/early/2017/12/13/IAI.00849-17.abstract
Naujoks J, Lippmann, J, Suttorp N, Opitz, B
Innate sensing and cell-autonomous resistance pathways in Legionella pneumophila infection.
Int J Med Microbiol. 2017 Oct 27. pii: S1438-4221(17)30306-5.
Opitz B
Inflammasome Deficiency Makes Pro-resolving Lipid Mediators Great Again.
Am J Respir Crit Care Med. 2017;196:668-669
Seeberger PH, Pereira CL, Khan N, Xiao G, Diago-Navarro E, Reppe K, Opitz B, Fries BC, Witzenrath M
A semi-synthetic glycoconjugate vaccine candidate for carbapenem-resistant Klebsiella pneumoniae.
Angew Chem Int Ed Engl. 2017 Aug 16
Patel S, Blaauboer SM, Tucker HR, Mansouri S, Ruiz-Moreno JS, Hamann L, Schumann RR, Opitz B, Jin L
The Common R71H-G230A-R293Q Human TMEM173 Is a Null Allele.
J Immunol December 7, 2016, 1601585
http://www.jimmunol.org/content/early/2016/12/07/jimmunol.1601585.abstract
Kostadinova E, Chaput C, Gutbier B, Lippmann J, Sander LE, Mitchell TJ, Suttorp N, Witzenrath M, Opitz B
NLRP3 protects alveolar barrier integrity by an inflammasome-independent increase of epithelial cell adherence
Sci Rep. 2016 Aug 1;6:30943
Rabes A, Suttorp N, Opitz B
Inflammasomes in Pneumococcal Infection: Innate Immune Sensing and Bacterial Evasion Strategies.
Curr Top Microbiol Immunol. 2016;397:215-27
Tabeling C, Noe E, Naujoks J, Doehn JM, Hippenstiel S, Opitz B, Suttorp N, Klopfleisch R, Witzenrath M
PKCα Deficiency in Mice Is Associated with Pulmonary Vascular Hyperresponsiveness to Thromboxane A2 and Increased Thromboxane Receptor Expression.
J Vasc Res. 2015;52(4):279-88
Naujoks J, Tabeling C, Dill BD, Hoffmann C, Brown AS, Kunze M, Kempa S, Peter A, Mollenkopf HJ, Dorhoi A, Kershaw O, Gruber AD, Sander LE, Witzenrath M, Herold S, Nerlich A, Hocke AC, van Driel I, Suttorp N, Bedoui S, Hilbi H, Trost M, Opitz B
IFNs Modify the Proteome of Legionella-Containing Vacuoles and Restrict Infection Via IRG1-Derived Itaconic Acid.
PLoS Pathog. 2016 Feb 1;12(2)
Fatykhova D, Rabes A, Machnik C, Guruprasad K, Pache F, Berg J, Toennies M, Bauer TT, Schneider P, Schimek M, Eggeling S, Mitchell TJ, Mitchell AM, Hilker R, Hain T, Suttorp N, Hippenstiel S, Hocke AC, Opitz B
Serotype 1 and 8 Pneumococci Evade Sensing by Inflammasomes in Human Lung Tissue.
PLoS One. 2015 Aug 28;10(8):e0137108
Müller-Redetzky HC, Wienhold SM, Berg J, Hocke AC, Hippenstiel S, Hellwig K, Gutbier B, Opitz B, Neudecker J, Rückert J, Gruber AC, Kershaw O, Mayer K, Suttorp N, Witzenrath M
Moxifloxacin is not anti-inflammatory in experimental pneumococcal pneumonia.
J Antimicrob Chemother. 2015 Mar;70(3):830-40
Rabes A, Zimmermann S, Reppe K, Lang R, Seeberger PH, Suttorp N, Witzenrath M, Lepenies B, Opitz B
The C-type lectin receptor Mincle binds to Streptococcus pneumoniae but plays a limited role in the anti-pneumococcal innate immune response.
PLoS One. 2015 Feb 6;10(2):e0117022
Müller-Redetzky HC, Felten M, Hellwig K, Wienhold SM, Naujoks J, Opitz B, Kershaw O, Gruber AD, Suttorp N, Witzenrath M
Increasing the inspiratory time and I:E ratio during mechanical ventilation aggravates ventilator-induced lung injury in mice.
Critical Care 2015, 19:23
Noe E, Tabeling C, Doehn JM, Naujoks J, Opitz B, Hippenstiel S, Witzenrath M, Klopfleisch R
Juvenile megaesophagus in PKCα-deficient mice is associated with an increase in the segment of the distal esophagus lined by smooth muscle cells.
Ann Anat. 2014 Sep;196(5):365-71
Tabeling C, Scheer H, Schönrock SM, Runge F, Gutbier B, Lienau J, Hamelmann E, Opitz B, Suttorp N, Mayer K, Behrens GM, Tschernig T, Witzenrath M
Nucleotide oligomerization domain 1 ligation suppressed murine allergen-specific T-cell proliferation and airway hyperresponsiveness.
Am J Respir Cell Mol Biol. 2014 May;50(5):903-11
Tabeling C, Scheer H, Schönrock SM, Runge F, Gutbier B, Lienau J, Hamelmann E, Opitz B, Suttorp N, Mayer K, Behrens GM, Tschernig T, Witzenrath M.
NOD1 Ligation Suppressed Murine Allergen-Specific T Cell Proliferation and Airway Hyperresponsiveness.
Am J Respir Cell Mol Biol. 2013 Nov 26.
Naujoks J, Opitz B
Bacterial infections and the DNA sensing pathway
Bookchapter DNA Sensing: The impact of dsDNA on Disease and Vaccinology. Edited by Ken Ishii and Jason C.K. Tang; Elsevier
http://store.elsevier.com/Biological-DNA-Sensor/isbn-9780124047327
Chaput C, Sander LE, Suttorp N, Opitz B
NOD-Like Receptors in Lung Diseases.
Front Immunol. 2013, 4, 393.
Helbig ET, Opitz B, Sander LE
Adjuvant immunotherapies as a novel approach to bacterial infections
Immunotherapy. 2013;5, 365-81.
Yu P, Lübben W, Slomka H, Gebler J, Konert M, Cai C, Neubrandt L, Prazeres da Costa O, Paul S, Dehnert S, Döhne K, Thanisch M, Storsberg S, Wiegand L, Kaufmann A, Nain M, Quintanilla-Martinez L, Bettio S, Schnierle B, Kolesnikova L, Becker S, Schnare M,
Nucleic acid-sensing Toll-like receptors are essential for the control of endogenous retrovirus viremia and ERV-induced tumors
Immunity. 2012 Nov 16;37(5):867-79. doi: 10.1016/j.immuni.2012.07.018.
Oldenburg M, Krüger A, Ferstl R, Kaufmann A, Nees G, Sigmund A, Bathke B, Lauterbach H, Suter M, Dreher S, Koedel U, Akira S, Kawai T, Buer J, Wagner H, Bauer S, Hochrein H, Kirschning CJ
TLR13 recognizes bacterial 23S rRNA devoid of erythromycin resistance-forming modification
Science. 2012 Aug 31;337(6098):1111-5. doi: 10.1126/science.1220363. Epub 2012 Jul 19
Koppe U, Suttorp N, Opitz B
Recognition of Streptococcus pneumoniae by the innate immune system.
Cell Microbiol. 2012 Apr;14(4):460-6. doi: 10.1111/j.1462-5822.2011.01746.x. Epub 2012 Feb 8
Jöckel S, Nees G, Sommer R, Zhao Y, Cherkasov D, Hori H, Ehm G, Schnare M, Nain M, Kaufmann A, Bauer S
The 2´-O-methylation status of a single guanosine controls transfer RNA-mediated Toll-like receptor 7 activation or inhibition
J Exp Med. 2012 Feb 13;209(2):235-41. Epub 2012 Feb 6.
Eitel J, Meixenberger K, van Laak C, Orlovski C, Hocke A, Schmeck B, Hippenstiel S, N’Guessan PD, Suttorp N, Opitz B
Rac1 regulates the NLRP3 inflammasome which mediates IL-1beta production in Chlamydophila pneumoniae infected human mononuclear cells.
PLoS One. 2012;7(1):e30379. doi: 10.1371/journal.pone.0030379. Epub 2012 Jan 20.
Koppe U, Högner K, Witzenrath M, Bauer S, Hammerschmidt S, Suttorp N, Herold S, Opitz B.
Streptococcus pneumoniae stimulates a STING- and IFN regulatory factor 3-dependent type I IFN production in macrophages, which regulates RANTES production in macrophages, cocultured alveolar epithelial cells, and mouse lungs.
J Immunol. 2012 Jan 15;188(2):811-7
Lippmann J, Müller H, Naujoks J, Tabeling C, Shin S, Witzenrath M, Hellwig K, Kirschning CJ, Taylor GA, Barchet W, Bauer S, Suttorp N, Roy CR, Opitz B
Dissection of a type I interferon pathway in controlling bacterial intracellular infection in mice.
Cell Microbiol. 2011 Nov;13(11):1668-82. doi: 10.1111/j.1462-5822.2011.01646.x. Epub 2011 Aug 24
Witzenrath M, Pache F, Lorenz D, Koppe U, Schönrock S, Meixenberger K, Dorhoi A, Ma J, Holmes A, Trendelenburg G, Heimesaat MM, Bereswill S, van der Linden M, Tschopp J, Mitchell TJ, Suttorp N, Opitz B.
The NLRP3 Inflammasome is Differentially Activated by Pneumolysin Variants and Contributes to Host Defense in Pneumococcal Pneumonia.
J Immunol. 2011 Jul 1;187(1):434-40. Epub 2011 Jun 6.
Eitel J, Suttorp N, Opitz B.
Innate immune recognition and inflammasome activation in Listeria monocytogenes infection.
Front Microbiol. 2011;1: 149
Lorenz J, Zahlten J, Pollok I, Lippmann J, Scharf S, N´Guessan PD, Opitz B, Flieger A, Suttorp N, Hippenstiel S, Schmeck B.
Legionella pneumophila-induced I?B?-dependent expression of interleukin-6 in lung epithelium.
Eur Respir J. 2011 Mar;37(3):648-57. Epub 2010 Jul 22.
Scharf S, Vardarova K, Lang F, Schmeck B, Opitz B, Flieger A, Heuner K, Hippenstiel S, Suttorp N, N´Guessan PD.
Legionella pneumophila induces human beta defensin-3 in pulmonary cells.
Respir Res. 2010 Jul 8;11:93.
Zahlten J, Steinicke R, Opitz B, Eitel J, N´guessan PD, Vinzing M, Witzenrath M, Schmeck B, Hammerschmidt S, Suttorp N, Hippenstiel S.
TLR2- and nucleotide-binding oligomerization domain 2-dependent Krüppel-like factor 2 expression downregulates NF-kappa B-related gene expression.
J Immunol. 2010 Jul 1;185(1):597-604. Epub 2010 Jun 4
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