Publications
Felten M, Ferencik S, Teixeira Alves LG, Letsiou E, Lienau J, Müller-Redetzky HC, Langenhagen AK, Voß A, Dietert K, Kershaw O, Gruber AD, Michalick L, Kuebler WM, Ananthasubramaniam B, Maier B, Uhlenhaut H, Kramer A, Witzenrath M.
Ventilator-induced Lung Injury Is Modulated by the Circadian Clock.
Am J Respir Crit Care Med. 2023 Jun 1;207(11):1464-1474. https://pubmed.ncbi.nlm.nih.gov/36480958/
Nouailles G, Adler JM, Pennitz P, Peidli S, Teixeira Alves LG, Baumgardt M, Bushe J, Voss A, Langenhagen A, Langner C, Martin Vidal R, Pott F, Kazmierski J, Ebenig A, Lange MV, Mühlebach MD, Goekeri C, Simmons S, Xing N, Abdelgawad A, Herwig S, Cichon G, Niemeyer D, Drosten C, Goffinet C, Landthaler M, Blüthgen N, Wu H, Witzenrath M, Gruber AD, Praktiknjo SD, Osterrieder N, Wyler E, Kunec D, Trimpert J.
Live-attenuated vaccine sCPD9 elicits superior mucosal and systemic immunity to SARS-CoV-2 variants in hamsters
Nat Microbiol. 2023 May;8(5):860-874. doi: 10.1038/s41564-023-01352-8.. https://pubmed.ncbi.nlm.nih.gov/37012419/
Felten M, Dame C, Lachmann G, Spies C, Rubarth K, Balzer F, Kramer A, Witzenrath M.
Circadian rhythm disruption in critically ill patients.
Acta Physiol (Oxf). 2023 May;238(1):e13962. doi: 10.1111/apha.13962. https://pubmed.ncbi.nlm.nih.gov/36916859/
Goekeri C, Pennitz P, Groenewald W, Behrendt U, Kirsten H, Zobel CM, Berger S, Heinz GA, Mashreghi MF, Wienhold SM, Dietert K, Dorhoi A, Gruber AD, Scholz M, Rohde G, Suttorp N, Capnetz Study Group, Witzenrath M, Nouailles G.
MicroRNA-223 Dampens Pulmonary Inflammation during Pneumococcal Pneumonia.
Cells. 2023 Mar 21;12(6):959. doi: 10.3390/cells12060959.PMID: 36980300 https://pubmed.ncbi.nlm.nih.gov/36980300/
Weissfuss C, Wienhold SM, Bürkle M, Gaborieau B, Bushe J, Behrendt U, Bischoff R, Korf IHE, Wienecke S, Dannheim A, Ziehr H, Rohde C, Gruber AD, Ricard JD, Debarbieux L, Witzenrath M, Nouailles G.
Repetitive Exposure to Bacteriophage Cocktails against Pseudomonas aeruginosa or Escherichia coli Provokes Marginal Humoral Immunity in Naïve Mice
Viruses. 2023 Jan 29;15(2):387. doi: 10.3390/v15020387. https://pubmed.ncbi.nlm.nih.gov/36851601/
Pennitz P, Goekeri C, Trimpert J, Wyler E, Ebenig A, Weissfuss C, Mühlebach MD, Witzenrath M, Nouailles G.
Protocol to dissociate healthy and infected murine- and hamster-derived lung tissue for single-cell transcriptome analysis.
STAR Protoc. 2022 Dec 20;4(1):101957. doi: 10.1016/j.xpro.2022.101957. https://pubmed.ncbi.nlm.nih.gov/36542521/
Erfinanda L, Zou L, Gutbier B, Kneller L, Weidenfeld S, Michalick L, Lei D, Reppe K, Teixeira Alves LG, Schneider B, Zhang Q, Li C, Fatykhova D, Schneider P, Liedtke W, Sohara E, Mitchell TJ, Gruber AD, Hocke A, Hippenstiel S, Suttorp N, Olschewski A, Mall MA, Witzenrath M, Kuebler WM
Loss of endothelial CFTR drives barrier failure and edema formation in lung infection and can be targeted by CFTR potentiation
Sci Transl Med. 2022 Dec 7;14(674):eabg8577.
doi: 10.1126/scitranslmed.abg8577. https://pubmed.ncbi.nlm.nih.gov/36475904/
Fiocca Vernengo F, Opitz B.
TBK1's role in bacterial pneumonia: Perhaps more than macrophages and
Am J Respir Cell Mol Biol. 2022 Jun;66(6):596-597. doi: 10.1165/rcmb.2022-0040ED.
https://pubmed.ncbi.nlm.nih.gov/35363998/
Hönzke K, Obermayer B, Mache C, Fathykova D, Kessler M, Dökel S, Wyler E, Baumgardt M, Löwa A, Hoffmann K, Graff P, Schulze J, Mieth M, Hellwig K, Demir Z, Biere B, Brunotte L, Mecate-Zambrano A, Bushe J, Dohmen M, Hinze C, Elezkurtaj S, Tönnies M, Bauer TT, Eggeling S, Tran HL, Schneider P, Neudecker J, Rückert JC, Schmidt-Ott KM, Busch J, Klauschen F, Horst D, Radbruch H, Radke J, Heppner F, Corman VM, Niemeyer D, Müller MA, Goffinet C, Mothes R, Pascual-Reguant A, Hauser AE, Beule D, Landthaler M, Ludwig S, Suttorp N, Witzenrath M, Gruber AD, Drosten C, Sander LE, Wolff T, Hippenstiel S, Hocke AC
Human lungs show limited permissiveness for SARS-CoV-2 due to scarce ACE2 levels but virus-induced expansion of inflammatory macrophages
Eur Respir J. 2022 Dec 1;60(6):2102725. doi: 10.1183/13993003.02725-2021.
https://pubmed.ncbi.nlm.nih.gov/35728978/
Lask A, Gutbier B, Kershaw O, Nouailles G, Gruber AD, Müller-Redetzky HC, Chackowicz S, Hamilton DA, Van Slyke P, Witzenrath M.
Adjunctive therapy with the Tie2 agonist Vasculotide reduces pulmonary permeability in Streptococcus pneumoniae infected and mechanically ventilated mice
Sci Rep. 2022 Sep 15;12(1):15531. doi: 10.1038/s41598-022-19560-3 https://pubmed.ncbi.nlm.nih.gov/36109537/
Aznaourova M, Schmerer N, Janga H, Zhang Z, Pauck K, Bushe J, Volkers SM, Wendisch D, Georg P, Ntini E, Aillaud M, Gündisch M, Mack E, Skevaki C, Keller C, Bauer C, Bertrams W, Marsico A, Nist A, Stiewe T, Gruber AD, Ruppert C, Li Y, Garn H, Sander LE, Schmeck B, Schulte LN.
Single-cell RNA sequencing uncovers the nuclear decoy lincRNA PIRAT as a regulator of systemic monocyte immunity during COVID-19
Proc Natl Acad Sci USA. 2022 Sep 6;119(36):e2120680119. doi: 10.1073/pnas.2120680119. Epub 2022 Aug 23. https://pubmed.ncbi.nlm.nih.gov/35998224/
Kunec D, Osterrieder N, Trimpert J.
Synthetically recoded virus sCPD9 – A tool to accelerate SARS-CoV-2 research under biosafety level 2 conditions
Comput Struct Biotechnol J . 2022;20:4376-4380. doi: 10.1016/j.csbj.2022.08.027. Epub 2022 Aug 13. https://pubmed.ncbi.nlm.nih.gov/35992535/
Hoffmann K, Obermayer B, Hönzke K, Fatykhova D, Demir Z, Löwa A, Alves LGT, Wyler E, Lopez-Rodriguez E, Mieth M, Baumgardt M, Hoppe J, Firsching TC, Tönnies M, Bauer TT, Eggeling S, Tran HL, Schneider P, Neudecker J, Rückert JC, Gruber AD, Ochs M, Landthaler M, Beule D, Suttorp N, Hippenstiel S, Hocke AC, Kessler M.
Human alveolar progenitors generate dual lineage bronchioalveolar organoids
Commun Biol. 2022 Aug 25;5(1):875. doi: 10.1038/s42003-022-03828-5. https://pubmed.ncbi.nlm.nih.gov/36008580/
Pennitz P, Kirsten H, Friedrich VD, Wyler E, Goekeri C, Obermayer B, Heinz GA, Mashreghi MF, Büttner M, Trimpert J, Landthaler M, Suttorp N, Hocke AC, Hippenstiel S, Tönnies M, Scholz M, Kuebler WM, Witzenrath M, Hoenzke K, Nouailles G.
A pulmonologist's guide to perform and analyse cross-species single lung cell transcriptomics
Eur Respir Rev. 2022 Jul 27;31(165):220056. doi: 10.1183/16000617.0056-2022. https://pubmed.ncbi.nlm.nih.gov/35896273/
Tabeling C, González Calera CR, Lienau J, Höppner J, Tschernig T, Kershaw O, Gutbier B, Naujoks J, Herbert J, Opitz B, Gruber AD, Hocher B, Suttorp N, Heidecke H, Burmester GR, Riemekasten G, Siegert E, Kuebler WM, Witzenrath M.
Endothelin B Receptor Immunodynamics in Pulmonary Arterial Hypertension.
Front Immunol. 2022 Jun 9;13:895501. https://pubmed.ncbi.nlm.nih.gov/35757687/
Wyler E, Adler JM, Eschke K, Teixeira Alves G, Peidli S, Pott F, Kazmierski J, Michalick L, Kershaw O, Bushe J, Andreotti S, Pennitz P, Abdelgawad A, Postmus D, Goffinet C, Kreye J, Reincke SM, Prüss H, Blüthgen N, Gruber AD, Kuebler WM, Witzenrath M, Landthaler M, Nouailles G, Trimpert J.
Key benefits of dexamethasone and antibody treatment in COVID-19 hamster models revealed by single-cell transcriptomics
Mol Ther. 2022 May 4;30(5):1952-1965. doi: 10.1016/j.ymthe.2022.03.014. Epub 2022 Mar 24. https://pubmed.ncbi.nlm.nih.gov/35339689/
Wienhold SM, Brack MC, Nouailles G, Krishnamoorthy G, Korf IHE, Seitz C, Wienecke S, Dietert K, Gurtner C, Kershaw O, Gruber AD, Ross A, Ziehr H, Rohde M, Neudecker J, Lienau J, Suttorp N, Hippenstiel S, Hocke AC, Rohde C, Witzenrath M.
Preclinical Assessment of Bacteriophage Therapy against Experimental Acinetobacter baumannii Lung Infection.
Viruses. 2021 Dec 24;14(1):33. https://pubmed.ncbi.nlm.nih.gov/35062236/
Trimpert J, Adler JM, Eschke K, Abdelgawad A, Firsching TC, Ebert N, Thao TTN, Gruber AD, Thiel V, Osterrieder N, Kunec D.
Live attenuated virus vaccine protects against SARS-CoV-2 variants of concern B.1.1.7 (Alpha) and B.1.351 (Beta).
Sci Adv. 2021 Dec 3;7(49):eabk0172. doi: 10.1126/sciadv.abk0172. Epub 2021 Dec 1. PMID: 34851677; PMCID: PMC8635430. pubmed.ncbi.nlm.nih.gov/34851677/
Gruber AD, Firsching TC, Trimpert J, Dietert K.
Hamster models of COVID-19 pneumonia reviewed: How human can they be?
Vet Pathol. 2021 Dec 2:3009858211057197. doi: 10.1177/03009858211057197. Epub ahead of print. PMID: 34856819. pubmed.ncbi.nlm.nih.gov/34856819/
Trimpert J, Herwig S, Stein J, Vladimirova D, Adler JM, Abdelgawad A, Firsching TC, Thoma T, Sehouli J, Osterrieder K, Gruber AD, Sawitzki B, Sander LE, Cichon G.
Deciphering the Role of Humoral and Cellular Immune Responses in Different COVID-19 Vaccines-A Comparison of Vaccine Candidate Genes in Roborovski Dwarf Hamsters.
Viruses. 2021 Nov 16;13(11):2290. doi: 10.3390/v13112290. PMID: 34835096; PMCID: PMC8625836. pubmed.ncbi.nlm.nih.gov/34835096/
Lee S, Yu Y, Trimpert J, Benthani F, Mairhofer M, Richter-Pechanska P, Wyler E, Belenki D, Kaltenbrunner S, Pammer M, Kausche L, Firsching TC, Dietert K, Schotsaert M, Martínez-Romero C, Singh G, Kunz S, Niemeyer D, Ghanem R, Salzer HJF, Paar C, Mülleder M, Uccellini M, Michaelis EG, Khan A, Lau A, Schönlein M, Habringer A, Tomasits J, Adler JM, Kimeswenger S, Gruber AD, Hoetzenecker W, Steinkellner H, Purfürst B, Motz R, Di Pierro F, Lamprecht B, Osterrieder N, Landthaler M, Drosten C, García-Sastre A, Langer R, Ralser M, Eils R, Reimann M, Fan DNY, Schmitt CA.
Virus-induced senescence is a driver and therapeutic target in COVID-19.
Nature. 2021 Nov;599(7884):283-289. doi: 10.1038/s41586-021-03995-1. Epub 2021 Sep 13. PMID: 34517409. pubmed.ncbi.nlm.nih.gov/34517409/
Herta T, Bhattacharyya A, Rosolowski M, Conrad C, Gurtner C, Gruber AD, Ahnert P, Gutbier B, Frey D, Suttorp N, Hippenstiel S, Zahlten J.
Krueppel-Like Factor 4 Expression in Phagocytes Regulates Early Inflammatory Response and Disease Severity in Pneumococcal Pneumonia.
Front Immunol. 2021 Sep 13;12:726135. doi: 10.3389/fimmu.2021.726135. PMID: 34589087; PMCID: PMC8473698. pubmed.ncbi.nlm.nih.gov/34589087/
Nouailles G, Wyler E, Pennitz P, Postmus D, Vladimirova D, Kazmierski J, Pott F, Dietert K, Muelleder M, Farztdinov V, Obermayer B, Wienhold SM, Andreotti S, Hoefler T, Sawitzki B, Drosten C, Sander LE, Suttorp N, Ralser M, Beule D, Gruber AD, Goffinet C, Landthaler M, Trimpert J, Witzenrath M.
Temporal omics analysis in Syrian hamsters unravel cellular effector responses to moderate COVID-19
Nat Commun. 2021 Aug 11;12(1):4869. doi: 10.1038/s41467-021-25030-7. https://pubmed.ncbi.nlm.nih.gov/34381043/
Trimpert J, Dietert K, Firsching TC, Ebert N, Thi Nhu Thao T, Vladimirova D, Kaufer S, Labroussaa F, Abdelgawad A, Conradie A, Höfler T, Adler JM, Bertzbach LD, Jores J, Gruber AD, Thiel V, Osterrieder N, Kunec D.
Development of safe and highly protective live-attenuated SARS-CoV-2 vaccine candidates by genome recoding
Cell Rep. 2021 Aug 3;36(5):109493. doi: 10.1016/j.celrep.2021.109493. Epub 2021 Jul 20. https://pubmed.ncbi.nlm.nih.gov/34320400/
Tabeling C, Wienhold SM, Birnhuber A, Brack MC, Nouailles G, Kershaw O, Firsching TC, Gruber AD, Lienau J, Marsh LM, Olschewski A, Kwapiszewska G, Witzenrath M.
Pulmonary fibrosis in Fra-2 transgenic mice is associated with decreased numbers of alveolar macrophages and increased susceptibility to pneumococcal pneumonia
Am J Physiol Lung Cell Mol Physiol. 2021 Mar 3. doi: 10.1152/ajplung.00505.2020. Epub ahead of print. PMID: 33655757. pubmed.ncbi.nlm.nih.gov/33655757/
Trimpert J, Vladimirova D, Dietert K, Abdelgawad A, Kunec D, Dökel S, Voss A, Gruber AD, Bertzbach LD, Osterrieder N.
The Roborovski Dwarf Hamster Is A Highly Susceptible Model for a Rapid and Fatal Course of SARS-CoV-2 Infection
Cell Rep. 2020 Dec 8;33(10):108488. doi: 10.1016/j.celrep.2020.108488
Gruber AD, Osterrieder N, Bertzbach LD, Vladimirova D, Greuel S, Ihlow J, Horst D, Trimpert J, and Dietert K.
Standardization of Reporting Criteria for Lung Pathology in SARS-CoV-2-infected Hamsters: What Matters?
Kreye J, Reincke SM, Kornau HC, Sanchez-Sendin E, Corman VM, Liu H, Yuan M, Wu NC, Zhu X, Lee CD, Trimpert J, Hoeltje M, Dietert K, Stoeffler L, von Wardenburg N, van Hoof S, Homeyer MA, Hoffmann J, Abdelgawad A, Gruber AD, Bertzbach LD, Vladimirova D, Li LY, Barthel PC, Skriner K, Hocke AC, Hippenstiel S, Witzenrath M, Suttorp N, Kurth F, Franke C, Endres M, Schmitz D, Jeworowski LM, Richter A, Schmidt ML, Schwarz T, Mueller MA, Drosten C, Wendisch D, Sander LE, Osterrieder N, Wilson IA, Pruess H.
A therapeutic non-self-reactive SARS-CoV-2 antibody protects from lung pathology in a COVID-19 hamster model.
Bertzbach LD, Vladimirova D, Dietert K, Abdelgawad A, Gruber AD, Osterrieder N, Trimpert J.
SARS-CoV-2 infection of Chinese hamsters (Cricetulus griseus) reproduces COVID-19 pneumonia in a well-established small animal model
Osterrieder N, Bertzbach LD, Dietert K, Abdelgawad A, Vladimirova D, Kunec D, Hoffmann D, Beer M, Gruber AD, Trimpert J.
Age-Dependent Progression of SARS-CoV-2 Infection in Syrian Hamsters
Sauerhering L, Kupke A, Meier L, Dietzel E, Hoppe J, Gruber AD, Gattenloehner S, Witte B, Fink L, Hofmann N, Zimmermann T, Goesmann A, Nist A, Stiewe T, Becker S, Herold S, Peteranderl C.
Cyclophilin Inhibitors Restrict Middle East Respiratory Syndrome Coronavirus Via Interferon λ In Vitro And In Mice
Erickson NA, Gruber AD, Mundhenk L.
The Family of Chloride Channel Regulator, Calcium-activated Proteins in the Feline Respiratory Tract: A Comparative Perspective on Airway Diseases in Man and Animal Models
J Comp Pathol. 2020 Jan;174:39-53. doi: 10.1016/j.jcpa.2019.10.193.
Dabrowski AN, Shrivastav A, Conrad C, Komma K, Weigel M, Dietert K, Gruber A, Bertrams W, Wilhelm J, Schmeck B, Reppe K, N'Guessan PD, Aly S, Suttorp N, Hain T, Zahlten J.
Peptidoglycan recognition protein 4 limits bacterial clearance and inflammation in lungs by control of the gut microbiota.
Front Immunol. 2019 Sep 20;10:2106
Lippitsch A, Baal N, Chukovetskyi Y, Cunningham S, Michel G, Dietert K, Gurtner C, Gruber AD, Bein G, Hackstein H
Plasmacytoid dendritic cell depletion modifies FoxP3+ T cell homeostasis and the clinical course of bacterial pneumonia in mice.
J Leukoc Biol. 2019 Jul 2
Baal N, Cunningham S, Obermann HL, Thomas J, Lippitsch A, Dietert K, Gruber AD, Kaufmann A, Michel G, Nist A, Stiewe T, Rupp O, Goesmann A, Zukunft S, Fleming I, Bein G, Lohmeyer J, Bauer S, Hackstein H
ADAR1 Is Required for Dendritic Cell Subset Homeostasis and Alveolar Macrophage Function.
J Immunol. 2019 Feb 15;202(4):1099-1111
Fischer K, Doehn JM, Herr C, Lachner C, Heinrich A, Kershaw O, Voss M, Jacobson MH, Gruber AD, Clauss M, Witzenrath M, Bals R, Gutbier B, Slevogt H.
Acute Moraxella catarrhalis infection of chronically smoke-exposed mice increases mechanisms of emphysema development: a pilot study.
Eur J Microbiol Immunol (Bp.) 2018;8(4):128-134. https://pubmed.ncbi.nlm.nih.gov/30719329/
Berger S, Gökeri C, Gupta SK, Vera J, Dietert K, Behrendt U, Lienau J, Wienhold SM, Gruber AD, Suttorp N, Witzenrath M*, Nouailles G*.
Delay in antibiotic therapy results in fatal disease outcome in murine pneumococcal pneumonia.
Crit Care 2018;22(1):287. https://pubmed.ncbi.nlm.nih.gov/30382866/
Wienhold SM, Macrì M, Nouailles G, Dietert K, Gurtner C, Gruber AD, Heimesaat MM, Lienau J, Schumacher F, Kleuser B, Opitz B, Suttorp N, Witzenrath M*, Müller-Redetzky HC*.
Ventilator-induced lung injury is aggravated by antibiotic mediated microbiota depletion in mice.
Crit Care. 2018;22(1):282. https://pubmed.ncbi.nlm.nih.gov/30373626/
Perniss A, Schmidt N, Gurtner C, Dietert K, Schwengers O, Weigel M, Hempe J, Ewers C, Pfeil U, Gärtner U, Gruber AD, Hain T, Kummer W
Bordetella pseudohinzii targets cilia and impairs tracheal cilia-driven transport in naturally acquired infection in mice.
Sci Rep. 2018 Apr 9;8(1):5681
Erickson NA, Dietert K, Enders J, Glauben R, Nouailles G, Gruber AD, Mundhenk L
Soluble mucus component CLCA1 modulates expression of leukotactic cytokines and BPIFA1 in murine alveolar macrophages but not in bone marrow-derived macrophages.
Histochem Cell Biol. 2018 Apr 2. doi: 10.1007/s00418-018-1664-y
Ugolini M, Gerhard J, Burkert S, Jensen KJ, Georg P, Ebner F, Thada S, Dietert K, Helbig ET, Opitz B, Kurth F, Dittrich N, Sumanlatha G, Blander JM, Gruber AD, Hartmann S, Boekschoten MV, Suttorp N, Müller M, Jungersen G, Schumann RR, Sander LE
Recognition of microbial viability via TLR8 promotes T follicular helper cell differentiation and vaccine responses.
Nat Immunol 2018
Shrivastav A, Dabrowski AN, Conrad C, Baal N, Hackstein H, Plog S, Dietert K, Gruber AD, N'Guessan PD, Aly S, Suttorp N, Zahlten J
Peptidoglycan Recognition Protein 3 Does Not Alter the Outcome of Pneumococcal Pneumonia in Mice.
Front Microbiol. 2018 Feb 1;9:103
Dietert K, Nouailles G, Gutbier B, Reppe K, Berger S, Jiang X, Schauer AE, Hocke AC, Herold S, Slevogt H, Witzenrath M, Suttorp N, Gruber AD
Digital Image Analyses on Whole Lung Slides in Mouse Models of Acute Pneumonia.
Am J Respir Cell Mol Biol. 2018 Jan 23.
https://www.atsjournals.org/doi/full/10.1165/rcmb.2017-0337MA
Mundhenk L, Erickson NA, Klymiuk N, and Gruber AD.
Interspecies Diversity of Chloride Channel Regulators, Calcium-Activated 3 Genes.
Gutbier B, Schönrock SM, Ehrler C, Haberberger R, Dietert K, Gruber AD, Kummer W, Michalik L, Kübler WM, Hocke AC, Szymanski K, Letsiou E, Lüth A, Schumacher F, Kleuser B, Mitchell TJ, Bertrams W, Schmeck B, Treue D, Klauschen F, Bauer TT, Tönnies M,
Sphingosine kinase 1 regulates inflammation and contributes to acute lung injury in pneumococcal pneumonia via the S1P receptor 2.
Crit Care Med. 2018 Jan 2.
Dietert K, Gutbier B, Wienhold SM, Reppe K, Jiang X, Yao L, Chaput C, Naujoks J, Brack M, Kupke A, Peteranderl C, Becker S, von Lachner C, Baal N, Slevogt H, Hocke AC, Witzenrath M, Opitz B, Herold S, Hackstein H, Sander LE, Suttorp N, Gruber AD
Spectrum of pathogen- and model-specific histopathologies in mouse models of acute pneumonia.
PLoS One. 2017 Nov 20;12(11):e0188251
Gutbier B, Jiang X, Dietert K, Ehrler C, Lienau J, Van Slyke P, Kim H, Van Hoang C, Maynes JT, Dumont DJ, Gruber AD, Weissmann N, Mitchell TJ, Suttorp N, Witzenrath M
Vasculotide reduces pulmonary hyperpermeability in experimental pneumococcal pneumonia.
Critical Care 2017 Nov 13;21(1):274
Berg J, Zscheppang K, Fatykhova D, Tönnies M, Bauer TT, Schneider P, Neudecker J, Rückert JC, Eggeling S, Schimek M, Gruber AD, Suttorp N, Hippenstiel S, Hocke AC
Tyk2 as a target for immune regulation in human viral/bacterial pneumonia.
Eur Respir J. 2017 Jul 13;50(1)
Peter A, Fatykhova D, Kershaw O, Gruber AD, Rueckert J, Neudecker J, Toennies M, Bauer TT, Schneider P, Schimek M, Eggeling S, Suttorp N, Hocke AC, Hippenstiel S
Localization and pneumococcal alteration of junction proteins in the human alveolar-capillary compartment.
Histochem Cell Biol. 2017 Jun;147(6):707-719
Winek K, Engel O, Koduah P, Heimesaat MM, Fischer A, Bereswill S, Dames C, Kershaw O, Gruber AD, Curato C, Oyama N, Meisel C, Meisel A, Dirnagl U
Depletion of cultivatable gut microbiota by broad-spectrum antibiotic pretreatment worsens outcome after murine stroke.
Stroke. 2016 May;47(5):1354-63
Tabeling C, Noe E, Naujoks J, Doehn JM, Hippenstiel S, Opitz B, Suttorp N, Klopfleisch R, Witzenrath M
PKCα Deficiency in Mice Is Associated with Pulmonary Vascular Hyperresponsiveness to Thromboxane A2 and Increased Thromboxane Receptor Expression.
J Vasc Res. 2015;52(4):279-88
Naujoks J, Tabeling C, Dill BD, Hoffmann C, Brown AS, Kunze M, Kempa S, Peter A, Mollenkopf HJ, Dorhoi A, Kershaw O, Gruber AD, Sander LE, Witzenrath M, Herold S, Nerlich A, Hocke AC, van Driel I, Suttorp N, Bedoui S, Hilbi H, Trost M, Opitz B
IFNs Modify the Proteome of Legionella-Containing Vacuoles and Restrict Infection Via IRG1-Derived Itaconic Acid.
PLoS Pathog. 2016 Feb 1;12(2)
Reppe K, Radünzel P, Dietert K, Tschernig T, Wolff T, Hammerschmidt S, Gruber AD, Suttorp N, Witzenrath M
Pulmonary immunostimulation with MALP-2 in influenza virus-infected mice increases survival after pneumococcal superinfection.
Infect Immun. 2015 Dec;83(12):4617-29
Hackstein H, Lippitsch A, Krug P, Schevtschenko I, Kranz S, Hecker M, Dietert K, Gruber AD, Bein G, Brendel C, Baal N
Prospectively defined murine mesenchymal stem cells inhibit Klebsiella pneumoniae-induced acute lung injury and improve pneumonia survival.
Respir Res. 2015 Oct 6;16:123
Zahlten J, Herta T, Kabus C, Steinfeldt M, Kershaw O, García P, Hocke AC, Gruber AD, Hübner RH, Steinicke R, Doehn JM, Suttorp N, Hippenstiel S
Role of Pneumococcal Autolysin for KLF4 Expression and Chemokine Secretion in Lung Epithelium.
Am J Respir Cell Mol Biol. 2015 Oct;53(4):544-54
Müller-Redetzky HC, Wienhold SM, Berg J, Hocke AC, Hippenstiel S, Hellwig K, Gutbier B, Opitz B, Neudecker J, Rückert J, Gruber AC, Kershaw O, Mayer K, Suttorp N, Witzenrath M
Moxifloxacin is not anti-inflammatory in experimental pneumococcal pneumonia.
J Antimicrob Chemother. 2015 Mar;70(3):830-40
Zahlten J, Herta T, Kabus C, Steinfeldt M, Kershaw O, García P, Hocke AC, Gruber AD, Hübner RH, Steinicke R, Doehn JM, Suttorp N, Hippenstiel S
Pneumococci LytA-dependent KLF4 Expression Terminates IL-8 Secretion in Lung Epithelium.
Am J Respir Cell Mol Biol. 2015 Mar 10
Dietert K, Mundhenk L, Erickson NA, Reppe K, Hocke AC, Kummer W, Witzenrath M, Gruber AD
Murine CLCA5 is uniquely expressed in distinct niches of airway epithelial cells.
Histochem Cell Biol. 2015 Mar;143(3):277-87. doi: 10.1007/s00418-014-1279-x.
Dames C, Akyüz L, Reppe K, Tabeling C, Dietert K, Kershaw O, Gruber AD, Meisel C, Meisel A, Witzenrath M, Engel O
Miniaturized bronchoscopy enables unilateral investigation, application, and sampling in mice.
Am J Respir Cell Mol Biol. 2014 Dec;51(6):730-7
Noe E, Tabeling C, Doehn JM, Naujoks J, Opitz B, Hippenstiel S, Witzenrath M, Klopfleisch R
Juvenile megaesophagus in PKCα-deficient mice is associated with an increase in the segment of the distal esophagus lined by smooth muscle cells.
Ann Anat. 2014 Sep;196(5):365-71
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