Transregional Collaborative Research Center SFB-TR 84 - “Innate Immunity of the Lung: Mechanisms of Pathogen Attack and Host Defence in Pneumonia“

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Publications

Dietert K, Gutbier B, Wienhold SM, Reppe K, Jiang X, Yao L, Chaput C, Naujoks J, Brack M, Kupke A, Peteranderl C, Becker S, von Lachner C, Baal N, Slevogt H, Hocke AC, Witzenrath M, Opitz B, Herold S, Hackstein H, Sander LE, Suttorp N, Gruber AD

Spectrum of pathogen- and model-specific histopathologies in mouse models of acute pneumonia.

PLoS One. 2017 Nov 20;12(11):e0188251

www.ncbi.nlm.nih.gov/pubmed/29155867

Gutbier B, Jiang X, Dietert K, Ehrler C, Lienau J, Van Slyke P, Kim H, Van Hoang C, Maynes JT, Dumont DJ, Gruber AD, Weissmann N, Mitchell TJ, Suttorp N, Witzenrath M

Vasculotide reduces pulmonary hyperpermeability in experimental pneumococcal pneumonia.

Critical Care 2017 Nov 13;21(1):274

www.ncbi.nlm.nih.gov/pubmed/29132435

Naujoks J, Lippmann, J, Suttorp N, Opitz, B

Innate sensing and cell-autonomous resistance pathways in Legionella pneumophila infection.

Int J Med Microbiol. 2017 Oct 27. pii: S1438-4221(17)30306-5.

www.ncbi.nlm.nih.gov/pubmed/29097162

Emmadi M, Khan N, Lykke L, Reppe K, Parameswarappa S, Lisboa MP, Wienhold SM, Witzenrath M, Pereira CL, Seeberger PH

A Streptococcus pneumoniae type 2 oligosaccharide glycoconjugate elicits opsonic antibodies and is protective in an animal model of invasive pneumococcal disease.

J Am Chem Soc 2017 Oct 4 [Epub ahead of print]

www.ncbi.nlm.nih.gov/pubmed/28945368

Lisboa MP, Khan N, Martin C, Xu FF, Reppe K, Geissner A, Govindan S, Witzenrath M, Pereira CL, Seeberger PH

Semisynthetic glycoconjugate vaccine candidate against Streptococcus pneumoniae serotype 5.

Proc Natl Acad Sci USA 2017 Oct 2 [Epub ahead of print]

www.ncbi.nlm.nih.gov/pubmed/28973947

Hess R, Wujak L, Hesse C, Sewald K, Jonigk D, Warnecke G, Fieguth HG, de Maat S, Maas C, Bonella F, Preissner KT, Weiss B, Schaefer L, Kuebler WM, Markart P, Wygrecka M

Coagulation factor XII regulates inflammatory responses in human lungs.

Thromb Haemost. 2017 Oct 5;117(10):1896-1907

www.ncbi.nlm.nih.gov/pubmed/28816340

Von Klitzing E, Bereswill S, Heimesaat MM

Multi-drug resistant Pseudomonas aeruginosa induce systemic pro-inflammatory immune responses in colonized mice.

Eur J Microbiol Immunol (Bp). 2017

www.ncbi.nlm.nih.gov/pubmed/29034109

Puri M, La Pietra L, Mraheil MA, Lucas R, Chakraborty T, Pillich H.

Listeriolysin O Regulates the Expression of Optineurin, an Autophagy Adaptor That Inhibits the Growth of Listeria monocytogenes.

Toxins (Basel). 2017; 9; pii: E273.

www.ncbi.nlm.nih.gov/pubmed/28872615

Zscheppang K, Berg J, Hedtrich S, Verheyen L, Wagner DE, Suttorp N, Hippenstiel S, Hocke AC

Human pulmonary 3D models for translational research.

Biotechnol J. 2017 Sep 2

www.ncbi.nlm.nih.gov/pubmed/28865134

Seeberger PH, Pereira CL, Khan N, Xiao G, Diago-Navarro E, Reppe K, Opitz B, Fries BC, Witzenrath M

A semi-synthetic glycoconjugate vaccine candidate for carbapenem-resistant Klebsiella pneumoniae.

Angew Chem Int Ed Engl. 2017 Aug 16

www.pubmed.de/gateway/nlm-pubmed/28815890

Keshavarz M, Schwarz H, Hartmann P, Wiegand W, Skill M, Althaus M, Kummer W, Krasteva-Christ G

Caveolin-1: functional insights into its role in muscarine- and serotonin-induced smooth muscle constriction in murine airways.

Front Physiol. 2017 May 15;8:295

www.ncbi.nlm.nih.gov/pubmed/28555112

Czikora I, Alli AA, Sridhar S, Matthay MA, Pillich H, Hudel M, Berisha B, Gorshkov B, Romero MJ, Gonzales J, Wu G, Huo Y, Su Y, Verin AD, Fulton D, Chakraborty T, Eaton DC, Lucas R.

Epithelial Sodium Channel-α Mediates the Protective Effect of the TNF-Derived TIP Peptide in Pneumolysin-Induced Endothelial Barrier Dysfunction.

Front Immunol. 2017; 8:842.

www.ncbi.nlm.nih.gov/pubmed/28785264

Wygrecka M, Kosanovic D, Wujak L, Reppe K, Henneke I, Frey H, Didiasova M, Kwapiszewska G, Marsh LM, Baal N, Hackstein H, Zakrzewicz D, Müller-Redetzky HC, de Maat S, Maas C, Nolte MW, Panousis C, Schermuly RT, Seeger W, Witzenrath M, Schaefer L, Markart P

Antihistone Properties of C1 Esterase Inhibitor Protect against Lung Injury.

Am J Respir Crit Care Med. 2017 Jul 15;196(2):186-199

www.ncbi.nlm.nih.gov/pubmed/28005404

Berg J, Zscheppang K, Fatykhova D, Tönnies M, Bauer TT, Schneider P, Neudecker J, Rückert JC, Eggeling S, Schimek M, Gruber AD, Suttorp N, Hippenstiel S, Hocke AC

Tyk2 as a target for immune regulation in human viral/bacterial pneumonia.

Eur Respir J. 2017 Jul 13;50(1)

erj.ersjournals.com/content/50/1/1601953

Tabeling C, Herbert J, Hocke AC, Lamb DJ, Wollin SL, Erb KJ, Boiarina E, Movassagh H, Scheffel J, Doehn JM, Hippenstiel S, Maurer M, Gounni AS, Kuebler WM, Suttorp N, Witzenrath M

Spleen tyrosine kinase inhibition blocks airway constriction and protects from Th2-induced airway inflammation and remodeling.

Allergy. 2017 Jul;72(7):1061-1072

www.ncbi.nlm.nih.gov/pubmed/ 27906453

Peter A, Fatykhova D, Kershaw O, Gruber AD, Rueckert J, Neudecker J, Toennies M, Bauer TT, Schneider P, Schimek M, Eggeling S, Suttorp N, Hocke AC, Hippenstiel S

Localization and pneumococcal alteration of junction proteins in the human alveolar-capillary compartment.

Histochem Cell Biol. 2017 Jun;147(6):707-719

www.ncbi.nlm.nih.gov/pubmed/28247028

Lippitsch A, Chukovetskyi Y, Baal N, Bein G, Hackstein H

Unique high and homogenous surface expression of the transferrin receptor CD71 on murine plasmacytoid dendritic cells in different tissues.

Cell Immunol. 2017 Jun;316:41-52

doi.org/10.1016/j.cellimm.2017.03.005

Schaefer MB, Schaefer CA, Hecker M, Morty RE, Witzenrath M, Seeger W, Mayer K

Co-incubation of PMN and CaCo-2 cells modulates inflammatory potential.

Cell Mol Biol (Noisy-le-grand) 2017; 63:119-126

www.ncbi.nlm.nih.gov/pubmed/28719356

Jentho E, Bodden M, Schulz C, Jung AL, Seidel K, Schmeck B, Bertrams W

microRNA-125a-3p is regulated by MyD88 in Legionella pneumophila infection and targets NTAN1.

PLoS One. 2017 Apr 26;12(4):e0176204

www.ncbi.nlm.nih.gov/pubmed/28445535

Hahm HS, Schlegel MK, Hurevich M, Eller S, Schuhmacher F, Hofmann J, Pagel K, and Seeberger PH

Automated glycan assembly using the Glyconeer 2.1 synthesizer.

Proc Natl Acad Sci U S A 114: E3385-E3389, 2017

www.ncbi.nlm.nih.gov/pubmed/28396442

Ekmekciu I, von Klitzing E, Fiebiger U, Escher U, Neumann C, Bacher P, Scheffold A, Kühl AA, Bereswill S, Heimesaat MM

Immune responses to broad-spectrum antibiotic treatment and fecal microbiota transplantation in mice.

Front Immunol. 2017 Apr 19;8:397

www.ncbi.nlm.nih.gov/pubmed/28469619

Peteranderl C, Sznajder JI, Herold S and Lecuona E

Inflammatory responses regulating alveolar ion transport during pulmonary infections.

Front Immunol. 2017 Apr 18;8:446

www.ncbi.nlm.nih.gov/pubmed/28458673

Peteranderl C, Herold S

The Impact of the Interferon/TNF-Related Apoptosis-Inducing Ligand Signaling Axis on Disease Progression in Respiratory Viral Infection and Beyond.

Front Immunol. 2017 Mar 22;8:313

www.ncbi.nlm.nih.gov/pubmed/28382038

Sadewasser A, Paki K, Eichelbaum K, Bogdanow B, Saenger S, Budt M, Lesch M, Hinz KP, Herrmann A, Meyer TF, Karlas A, Selbach M, Wolff T

Quantitative proteomic approach identifies Vpr binding protein as novel host factor supporting influenza A virus infections in human cells.

Mol Cell Proteomics. 2017 Mar 13

www.ncbi.nlm.nih.gov/pubmed/28289176

Schumann B, Hahm HS, Parameswarappa SG, Reppe K, Wahlbrink A, Govindan S, Kaplonek P, Pirofski LA, Witzenrath M, Anish C, Pereira CL, Seeberger PH

A semisynthetic Streptococcus pneumoniae serotype 8 glycoconjugate vaccine.

Sci Transl Med. 2017 Mar 8;9(380)

www.ncbi.nlm.nih.gov/pubmed/28275152

Schierhorn KL, Jolmes F, Bespalowa J, Saenger S, Peteranderl C, Dzieciolowski J, Budt M, Pleschka S, Herrmann A, Herold S, Wolff T

Influenza A virus virulence depends on two amino acids in the N-terminal domain of its NS1 protein facilitating inhibition of PKR.

J Virol. 2017 Mar 1. pii: JVI.00198-17

www.ncbi.nlm.nih.gov/pubmed/28250123

Hocke AC, Suttorp N, and Hippenstiel S

Human lung ex vivo infection models.

Cell Tissue Res. 2017 Mar;367(3):511-524

www.ncbi.nlm.nih.gov/pubmed/27999962

Wentker P, Eberhardt M, Dreyer FS, Bertrams W, Cantone M, Griss K, Schmeck B, Vera J

An Interactive Macrophage Signal Transduction Map Facilitates Comparative Analyses of High-Throughput Data.

An Interactive Macrophage Signal Transduction Map Facilitates Comparative Analyses of High-Throughput Data.

www.ncbi.nlm.nih.gov/pubmed/28137890

Jung AL, Hoffmann K, Herkt CE, Schulz C, Bertrams W, Schmeck B

Legionella pneumophila Outer Membrane Vesicles: Isolation and Analysis of Their Pro-inflammatory Potential on Macrophages.

J Vis Exp. 2017 Feb 22;(120)

www.jove.com/video/55146/legionella-pneumophila-outer-membrane-vesicles-isolation-analysis

Chen F, Wang Y, Rafikov R, Haigh S, Zhi WB, Kumar S, Doulias PT, Rafikova O, Pillich H, Chakraborty T, Lucas R, Verin AD, Catravas JD, She JX, Black SM, Fulton DJ.

RhoA S-nitrosylation as a regulatory mechanism influencing endothelial barrier function in response to G+-bacterial toxins.

Biochem Pharmacol. 2016 Dec 22. pii: S0006-2952(16)30494-4.

www.ncbi.nlm.nih.gov/pubmed/28017778

Druzd D, Matveeva O, Ince L, Harrison U, He W, Schmal C, Herzel H, Tsang AH, Kawakami N, Leliavski A, Uhl O, Yao L, Sander LE, Chen CS, Kraus K, de Juan A, Hergenhan SM, Ehlers M, Koletzko B, Haas R, Solbach W, Oster H, Scheiermann C

Lymphocyte Circadian Clocks Control Lymph Node Trafficking and Adaptive Immune Responses.

Immunity. 2017 Jan 17;46(1):120-132

www.sciencedirect.com/science/article/pii/S1074761316305179

Maurer J, Hupp S, Bischoff C, Foertsch C, Mitchell TJ, Chakraborty T, Iliev AI.

Distinct Neurotoxicity Profile of Listeriolysin O from Listeria monocytogenes.

Toxins (Basel). 2017; 9(1), pii: E34.

www.ncbi.nlm.nih.gov/pubmed/28098781

Patel S, Blaauboer SM, Tucker HR, Mansouri S, Ruiz-Moreno JS, Hamann L, Schumann RR, Opitz B, Jin L

The Common R71H-G230A-R293Q Human TMEM173 Is a Null Allele.

J Immunol December 7, 2016, 1601585

www.jimmunol.org/content/early/2016/12/07/jimmunol.1601585.abstract

Pillich H, Loose M, Zimmer KP, Chakraborty T

Diverse roles of endoplasmic reticulum stress sensors in bacterial infection.

Mol Cell Pediatr. 2016 Dec;3(1):9

www.ncbi.nlm.nih.gov/pubmed/26883353

Zakrzewicz D, Bergmann S, Didiasova M, Giaimo BD, Borggrefe T, Mieth M, Hocke AC, Lochnit G, Schaefer L, Hammerschmidt S, Preissner KT, Wygrecka M

Host-derived extracellular RNA promotes adhesion of Streptococcus pneumoniae to endothelial and epithelial cells.

Sci Rep. 2016 Nov 28;6:37758

www.ncbi.nlm.nih.gov/pubmed/27892961

Lucas R, Yue Q, Alli A, Duke BJ, Al-Khalili O, Thai TL, Hamacher J, Sridhar S, Lebedyeva I, Su H, Tzotzos S, Fischer B, Gameiro AF, Loose M, Chakraborty T, Shabbir W, Aufy M, Lemmens-Gruber R, Eaton DC, Czikora I.

The Lectin-like Domain of TNF Increases ENaC Open Probability through a Novel Site at the Interface between the Second Transmembrane and C-terminal Domains of the α-Subunit.

J Biol Chem. 2016; 291:23440-23451.

www.ncbi.nlm.nih.gov/pubmed/27645999

Parameswarappa SG, Reppe K, Geissner A, Ménová P, Govindan S, Calow AD, Wahlbrink A, Weishaupt MW, Monnanda BP, Bell RL, Pirofski LA, Suttorp N, Sander LE, Witzenrath M, Pereira CL, Anish C, Seeberger PH

A Semi-synthetic Oligosaccharide Conjugate Vaccine Candidate Confers Protection against Streptococcus pneumoniae Serotype 3 Infection.

Cell Chem Biol. 2016 Nov 2. pii: S2451-9456(16)30356-7

www.ncbi.nlm.nih.gov/pubmed/27818299

Schaefer MB, Schaefer CA, Schifferings S, Kuhlmann CR, Urban A, Benscheid U, Fischer T, Hecker M, Morty RE, Vadasz I, Herold S, Witzenrath M, Seeger W, Erdogan A, Mayer K

N-3 vs. n-6 fatty acids differentially influence calcium signalling and adhesion of inflammatory activated monocytes: impact of lipid rafts.

Inflamm Res. 2016 Nov;65(11):881-894

www.ncbi.nlm.nih.gov/pubmed/27384606

Garaude J, Acín-Pérez R, Martínez-Cano S, Enamorado M, Ugolini M, Nistal-Villán E, Hervás-Stubbs S, Pelegrín P, Sander LE, Enríquez JA, Sancho D

Mitochondrial respiratory-chain adaptations in macrophages contribute to antibacterial host defense.

Nat Immunol. 2016 Sep;17(9):1037-45

www.ncbi.nlm.nih.gov/pubmed/27348412

Du Bois I, Marsico A, Bertrams W, Schweiger MR, Caffrey BE, Sittka-Stark A, Eberhardt M, Vera J, Vingron M, Schmeck BT

Genome-wide Chromatin Profiling of Legionella pneumophila-Infected Human Macrophages Reveals Activation of the Probacterial Host Factor TNFAIP2.

J Infect Dis. 2016 Aug 1;214(3):454-63

www.ncbi.nlm.nih.gov/pubmed/27130431

Kostadinova E, Chaput C, Gutbier B, Lippmann J, Sander LE, Mitchell TJ, Suttorp N, Witzenrath M, Opitz B

NLRP3 protects alveolar barrier integrity by an inflammasome-independent increase of epithelial cell adherence

Sci Rep. 2016 Aug 1;6:30943

www.ncbi.nlm.nih.gov/pubmed/27476670

Peteranderl C, Herold S, Schmoldt C

Human Influenza Virus Infections.

Semin Respir Crit Care Med. 2016 Aug;37(4):487-500

www.ncbi.nlm.nih.gov/pubmed/27486731

Budach S, Heinig M, Marsico A

Principles of microRNA Regulation Revealed Through Modeling microRNA Expression Quantitative Trait Loci.

Genetics. 2016 Aug;203(4):1629-40

www.ncbi.nlm.nih.gov/pubmed/27260304

Rabes A, Suttorp N, Opitz B

Inflammasomes in Pneumococcal Infection: Innate Immune Sensing and Bacterial Evasion Strategies.

Curr Top Microbiol Immunol. 2016;397:215-27

www.ncbi.nlm.nih.gov/pubmed/27460812

Hackstein H, Tschipakow I, Bein G, Nold P, Brendel C, Baal N

Contact-dependent abrogation of bone marrow-derived plasmacytoid dendritic cell differentiation by murine mesenchymal stem cells.

Biochem Biophys Res Commun. 2016 Jul 15;476(1):15-20

www.ncbi.nlm.nih.gov/pubmed/27233615

Garn H, Bahn S, Baune BT, Binder EB, Bisgaard H, Chatila TA, Chavakis T, Culmsee C, Dannlowski U, Gay S, Gern J, Haahtela T, Kircher T, Müller-Ladner U, Neurath MF, Preissner KT, Reinhardt C, Rook G, Russell S, Schmeck B, Stappenbeck T, Steinhoff U, van Os J, Weiss S, Zemlin M, Renz H

Current concepts in chronic inflammatory diseases: Interactions between microbes, cellular metabolism, and inflammation.

J Allergy Clin Immunol. 2016 Jul;138(1):47-56

www.ncbi.nlm.nih.gov/pubmed/27373325

Mostafa A, Abdelwhab el-SM, Slanina H, Hussein MA, Kuznetsova I, Schüttler CG, Ziebuhr J, Pleschka S

Phylogenetic analysis of human influenza A/H3N2 viruses isolated in 2015 in Germany indicates significant genetic divergence from vaccine strains.

Arch Virol. 2016 Jun;161(6):1505-15

www.ncbi.nlm.nih.gov/pubmed/26973232

Winek K, Engel O, Koduah P, Heimesaat MM, Fischer A, Bereswill S, Dames C, Kershaw O, Gruber AD, Curato C, Oyama N, Meisel C, Meisel A, Dirnagl U

Depletion of cultivatable gut microbiota by broad-spectrum antibiotic pretreatment worsens outcome after murine stroke.

Stroke. 2016 May;47(5):1354-63

www.ncbi.nlm.nih.gov/pubmed/27056982

Winek K, Engel O, Koduah P, Heimesaat MM, Fischer A, Bereswill S, Dames C, Kershaw O, Gruber AD, Curato C, Oyama N, Meisel C, Meisel A, Dirnagl U

Depletion of cultivatable gut microbiota by broad-spectrum antibiotic pretreatment worsens outcome after murine stroke.

Stroke. 2016 May;47(5):1354-63

www.ncbi.nlm.nih.gov/pubmed/27056982

Du Bois I, Marsico A, Bertrams W, Schweiger M, Caffrey B, Sittka-Stark A, Vingron M, Schmeck B

Genome-wide chromatin profiling of Legionella pneumophila-infected human macrophages reveals activation of the pro-bacterial host factor TNFAIP2.

J Infect Dis. 2016 Apr 29. pii: jiw171

www.ncbi.nlm.nih.gov/pubmed/27130431

Jung AL, Stoiber C, Herkt CE, Schulz C, Bertrams W, Schmeck B

Legionella pneumophila-derived outer membrane vesicles promote bacterial replication in macrophages.

PLoS Pathog. 2016 Apr 22;12(4)

www.ncbi.nlm.nih.gov/pubmed/27105429

Kirschner F, Reppe K, Andresen N, Witzenrath M, Ebstein F, Kloetzel PM

Proteasome β5i subunit deficiency affects opsonin synthesis and aggravates pneumococcal pneumonia

PLoS One. 2016 Apr 21;11(4):e0153847.

www.ncbi.nlm.nih.gov/pubmed/27100179

Peteranderl C, Morales-Nebreda L, Selvakumar B, Lecuona E, Vadász I, Morty RE, Schmoldt C, Bespalowa J, Wolff T, Pleschka S, Mayer K, Gattenloehner S, Fink L, Lohmeyer J, Seeger W, Sznajder JI, Mutlu GM, Budinger GR, Herold S

Macrophage-epithelial paracrine crosstalk inhibits lung edema clearance during influenza infection.

J Clin Invest. 2016 Apr 1;126(4):1566-80

www.ncbi.nlm.nih.gov/pubmed/26999599

Griss K, Bertrams W, Sittka-Stark A, Seidel K, Stielow C, Hippenstiel S, Suttorp N, Eberhardt M, Wilhelm J, Vera J, Schmeck B

MicroRNAs constitute a negative feedback loop in Streptococcus pneumoniae induced macrophage activation.

J Infect Dis. 2016 Mar 16

www.ncbi.nlm.nih.gov/pubmed/26984146

Tabeling C, Noe E, Naujoks J, Doehn JM, Hippenstiel S, Opitz B, Suttorp N, Klopfleisch R, Witzenrath M

PKCα Deficiency in Mice Is Associated with Pulmonary Vascular Hyperresponsiveness to Thromboxane A2 and Increased Thromboxane Receptor Expression.

J Vasc Res. 2015;52(4):279-88

www.ncbi.nlm.nih.gov/pubmed/26890419

Short K, Kasper J, van der Aa S, Andeweg AC, Zaaraoui-Boutahar F, Goeijenbier M, Richard M, Herold S, Becker C, Scott DP, Limpens R, Koster AJ, Barcena M, Fouchier R, Kirkpatrick CJ, Kuiken T

Influenza virus damages the alveolar barrier by disrupting epithelial cell tight junctions.

Eur Respir J. 2016 Mar;47(3):954-66

www.ncbi.nlm.nih.gov/pubmed/ 26743480

Pillich H, Loose M, Zimmer KP, Chakraborty T

Diverse roles of endoplasmic reticulum stress sensors in bacterial infection.

Mol Cell Pediatr., 2016, 3(1):9

www.ncbi.nlm.nih.gov/pubmed/26883353

Naujoks J, Tabeling C, Dill BD, Hoffmann C, Brown AS, Kunze M, Kempa S, Peter A, Mollenkopf HJ, Dorhoi A, Kershaw O, Gruber AD, Sander LE, Witzenrath M, Herold S, Nerlich A, Hocke AC, van Driel I, Suttorp N, Bedoui S, Hilbi H, Trost M, Opitz B

IFNs Modify the Proteome of Legionella-Containing Vacuoles and Restrict Infection Via IRG1-Derived Itaconic Acid.

PLoS Pathog. 2016 Feb 1;12(2)

www.ncbi.nlm.nih.gov/pubmed/26829557

Hoffmann S, Harms H, Ulm L, Nabavi DG, Mackert BM, Schmehl I, Jungehulsing GJ, Montaner J, Bustamante A, Hermans M, Hamilton F, Göhler J, Malzahn U, Malsch C, Heuschmann PU, Meisel C, Meisel A

Stroke-induced immunodepression and dysphagia independently predict stroke-associated pneumonia - The PREDICT study.

J Cereb Blood Flow Metab. 2016 Jan 1:271678X16671964

www.ncbi.nlm.nih.gov/pubmed/27733675

Reppe K, Radünzel P, Dietert K, Tschernig T, Wolff T, Hammerschmidt S, Gruber AD, Suttorp N, Witzenrath M

Pulmonary immunostimulation with MALP-2 in influenza virus-infected mice increases survival after pneumococcal superinfection.

Infect Immun. 2015 Dec;83(12):4617-29

www.ncbi.nlm.nih.gov/pubmed/26371127

Krasteva-Christ G, Soultanova A, Schütz B, Papadakis T, Weiss C, Deckmann K, Chubanov V, Gudermann T, Voigt A, Meyerhof W, Boehm U, Weihe E, and Kummer W

Identification of cholinergic chemosensory cells in mouse tracheal and laryngeal glandular ducts.

Identification of cholinergic chemosensory cells in mouse tracheal and laryngeal glandular ducts.

www.ncbi.nlm.nih.gov/pubmed/26033492

Meisel A, Smith CJ

Stroke: Preventive antibiotics for stroke-associated pneumonia.

Nat Rev Neurol. 2015 Nov 3

www.ncbi.nlm.nih.gov/pubmed/26526533

Engel O, Akyüz L, da Costa Goncalves AC, Winek K, Dames C, Thielke M, Herold S, Böttcher C, Priller J, Volk HD, Dirnagl U, Meisel C, Meisel A

Cholinergic pathway suppresses pulmonary innate immunity facilitating pneumonia after stroke.

Stroke. 2015 Nov;46(11):3232-40

www.ncbi.nlm.nih.gov/pubmed/26451017

Hackstein H, Lippitsch A, Krug P, Schevtschenko I, Kranz S, Hecker M, Dietert K, Gruber AD, Bein G, Brendel C, Baal N

Prospectively defined murine mesenchymal stem cells inhibit Klebsiella pneumoniae-induced acute lung injury and improve pneumonia survival.

Respir Res. 2015 Oct 6;16:123

www.ncbi.nlm.nih.gov/pubmed/26438075

Zahlten J, Herta T, Kabus C, Steinfeldt M, Kershaw O, García P, Hocke AC, Gruber AD, Hübner RH, Steinicke R, Doehn JM, Suttorp N, Hippenstiel S

Role of Pneumococcal Autolysin for KLF4 Expression and Chemokine Secretion in Lung Epithelium.

Am J Respir Cell Mol Biol. 2015 Oct;53(4):544-54

www.ncbi.nlm.nih.gov/pubmed/ 25756955

Müller-Redetzky H, Lienau J, Suttorp N, Witzenrath M

Therapeutic strategies in pneumonia: going beyond antibiotics.

Eur Respir Rev. 2015 Sep;24(137):516-24

www.ncbi.nlm.nih.gov/pubmed/26324814

Loose M, Pillich H, Chakraborty T.

Fisetin protects against Listeria monocytogenes infection by reducing the listeriolysin O production.

J Infect Dis. 2015; pii:jiv437.

jid.oxfordjournals.org/content/early/2015/09/06/infdis.jiv437.long

Meisel A, Smith CJ

Prevention of stroke-associated pneumonia: where next?

Lancet. 2015 Sep 3. pii: S0140-6736(15)00127-0

www.ncbi.nlm.nih.gov/pubmed/26343837

Fatykhova D, Rabes A, Machnik C, Guruprasad K, Pache F, Berg J, Toennies M, Bauer TT, Schneider P, Schimek M, Eggeling S, Mitchell TJ, Mitchell AM, Hilker R, Hain T, Suttorp N, Hippenstiel S, Hocke AC, Opitz B

Serotype 1 and 8 Pneumococci Evade Sensing by Inflammasomes in Human Lung Tissue.

PLoS One. 2015 Aug 28;10(8):e0137108

www.ncbi.nlm.nih.gov/pubmed/26317436

Gutbier B, Fischer K, Doehn JM, von Lachner C, Herr C, Klaile E, Frischmann U, Singer BB, Riesbeck K, Zimmermann W, Suttorp N, Bachmann S, Bals R, Witzenrath M, Slevogt H

Moraxella catarrhalis induces an immune response in the murine lung that is independent of human CEACAM5 expression and long-term smoke exposure.

Am J Physiol Lung Cell Mol Physiol. 2015 Aug 1;309(3):L250-61

www.ncbi.nlm.nih.gov/pubmed/26047639

Recum-Knepper J, Sadewasser A, Weinheimer VK, Wolff T

Fluorescence-Activated Cell Sorting-Based Analysis Reveals an Asymmetric Induction of Interferon-Stimulated Genes in Response to Seasonal Influenza A Virus.

J Virol. 2015 Jul 15;89(14):6982-93

www.ncbi.nlm.nih.gov/pubmed/25903337

Soultanova A, Voigt A, Chubanov V, Gudermann T, Meyerhof W, Boehm U, Kummer W

Cholinergic chemosensory cells of the thymic medulla express the bitter receptor Tas2r131.

Int Immunopharmacol. 2015 Nov;29(1):143-7

www.ncbi.nlm.nih.gov/pubmed/26102274

Smith CJ, Kishore AK, Vail A, Chamorro A, Garau J, Hopkins SJ, Di Napoli M, Kalra L, Langhorne P, Montaner J, Roffe C, Rudd AG, Tyrrell PJ, van de Beek D, Woodhead M, Meisel A.

Diagnosis of Stroke-Associated Pneumonia: Recommendations From the Pneumonia in Stroke Consensus Group.

Stroke. 2015 Jun 25. pii: STROKEAHA.115.009617.

www.ncbi.nlm.nih.gov/pubmed/26111886

Mühlbauer D, Dzieciolowski J, Hardt M, Hocke A, Schierhorn KL, Mostafa A, Müller C, Wisskirchen C, Herold S, Wolff T, Ziebuhr J, Pleschka S

Influenza virus-induced caspase-dependent enlargement of nuclear pores promotes nuclear export of viral ribonucleoprotein complexes.

J Virol. 2015 Jun 1;89(11):6009-21

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Jung S, von Thulen T, Laukemper V, Pigisch S, Hangel D, Wagner H, Kaufmann A, Bauer S

A single naturally occurring 2'-O-methylation converts a TLR7- and TLR8-activating RNA into a TLR8-specific ligand.

A single naturally occurring 2'-O-methylation converts a TLR7- and TLR8-activating RNA into a TLR8-specific ligand.

www.ncbi.nlm.nih.gov/pubmed/25785446

Hecker M, Linder T, Ott J, Walmrath HD, Lohmeyer J, Vadász I, Marsh LM, Herold S, Reichert M, Buchbinder A, Morty RE, Bausch B, Fischer T, Schulz R, Grimminger F, Witzenrath M, Barnes M, Seeger W, Mayer K

Immunomodulation by lipid emulsions in pulmonary inflammation: a randomized controlled trial.

Crit Care. 2015 May 12;19:226

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Müller-Redetzky HC, Wienhold SM, Berg J, Hocke AC, Hippenstiel S, Hellwig K, Gutbier B, Opitz B, Neudecker J, Rückert J, Gruber AC, Kershaw O, Mayer K,  Suttorp N, Witzenrath M

Moxifloxacin is not anti-inflammatory in experimental pneumococcal pneumonia.

J Antimicrob Chemother. 2015 Mar;70(3):830-40

www.ncbi.nlm.nih.gov/pubmed/25406299

Kishore AK, Vail A, Chamorro A, Garau J, Hopkins SJ, Di Napoli M, Kalra L, Langhorne P, Montaner J, Roffe C, Rudd AG, Tyrrell PJ, van de Beek D, Woodhead M, Meisel A, Smith CJ

How is pneumonia diagnosed in clinical stroke research? A systematic review and meta-analysis.

Stroke. 2015 May;46(5):1202-9.

www.ncbi.nlm.nih.gov/pubmed/25858238

Meisel A

Preventive antibiotic therapy in stroke: PASSed away?

Lancet. 2015 Apr 18;385(9977):1486-7

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Tabeling C, Yu H, Wang L, Ranke H, Goldenberg NM, Zabini D, Noe E, Krauszman A, Gutbier B, Yin J, Schaefer M, Arenz C, Hocke AC, Suttorp N, Proia RL, Witzenrath M, Kuebler WM

CFTR and sphingolipids mediate hypoxic pulmonary vasoconstriction.

Proc Natl Acad Sci U S A. 2015 Mar 31;112(13):E1614-23

www.ncbi.nlm.nih.gov/pubmed/25829545

Didiasova M, Zakrzewicz D, Magdolen V, Nagaraj C, Bálint Z, Rohde M, Preissner KT, Wygrecka M

STIM1/ORAI1-mediated Ca2+ Influx Regulates Enolase-1 Exteriorization.

J Biol Chem. 2015 May 8;290(19):11983-99

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Wujak L, Didiasova M, Zakrzewicz D, Frey H, Schaefer L, Wygrecka M

Heparan sulfate proteoglycans mediate factor XIIa binding to the cell surface.

J Biol Chem. 2015 Mar 13;290(11):7027-39

www.ncbi.nlm.nih.gov/pubmed/25589788

Zahlten J, Herta T, Kabus C, Steinfeldt M, Kershaw O, García P, Hocke AC, Gruber AD, Hübner RH, Steinicke R, Doehn JM, Suttorp N, Hippenstiel S

Pneumococci LytA-dependent KLF4 Expression Terminates IL-8 Secretion in Lung Epithelium.

Am J Respir Cell Mol Biol. 2015 Mar 10

www.ncbi.nlm.nih.gov/pubmed/25756955

Dietert K, Mundhenk L, Erickson NA, Reppe K, Hocke AC, Kummer W, Witzenrath M, Gruber AD

Murine CLCA5 is uniquely expressed in distinct niches of airway epithelial cells.

Histochem Cell Biol. 2015 Mar;143(3):277-87. doi: 10.1007/s00418-014-1279-x.

www.ncbi.nlm.nih.gov/pmc/articles/PMC4317516/

Cabrera-Fuentes HA, Lopez ML, McCurdy S, Fischer S, Meiler S, Baumer Y, Galuska SP, Preissner KT, Boisvert WA

Regulation of monocyte/macrophage polarisation by extracellular RNA.

Thromb Haemost. 2015 Mar;113(3):473-81

www.ncbi.nlm.nih.gov/pubmed/25589344

Rabes A, Zimmermann S, Reppe K, Lang R, Seeberger PH, Suttorp N, Witzenrath M, Lepenies B, Opitz B

The C-type lectin receptor Mincle binds to Streptococcus pneumoniae but plays a limited role in the anti-pneumococcal innate immune response.

PLoS One. 2015 Feb 6;10(2):e0117022

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Müller-Redetzky HC, Felten M, Hellwig K, Wienhold SM, Naujoks J, Opitz B, Kershaw O, Gruber AD, Suttorp N, Witzenrath M

Increasing the inspiratory time and I:E ratio during mechanical ventilation aggravates ventilator-induced lung injury in mice.

Critical Care 2015, 19:23

www.ncbi.nlm.nih.gov/pubmed/25888164

Loose M, Hudel M, Zimmer KP, Garcia E, Hammerschmidt S, Lucas R, Chakraborty T, Pillich H

Pneumococcal hydrogen peroxide-induced stress signaling regulates inflammatory genes.

J Infect Dis. 2015 Jan 15;211(2):306-16

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Zahlten J, Kim YJ, Doehn JM, Pribyl T, Hocke AC, García P, Hammerschmidt S, Suttorp N, Hippenstiel S, Hübner RH

Streptococcus pneumoniae-Induced Oxidative Stress in Lung Epithelial Cells Depends on Pneumococcal Autolysis and Is Reversible by Resveratrol.

J Infect Dis. 2015 Jun 1;211(11):1822-1830

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Saffarzadeh M, Preissner KT

Moonlighting proteins dictate the crosstalk between thrombosis and innate immunity.

J Thromb Haemost. 2014 Dec;12(12):2070-3

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Dames C, Akyüz L, Reppe K, Tabeling C, Dietert K, Kershaw O, Gruber AD, Meisel C, Meisel A, Witzenrath M, Engel O

Miniaturized bronchoscopy enables unilateral investigation, application, and sampling in mice.

Am J Respir Cell Mol Biol. 2014 Dec;51(6):730-7

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Savai R, Al-Tamari HM, Sedding D, Kojonazarov B, Muecke C, Teske R, Capecchi MR, Weissmann N, Grimminger F, Seeger W, Schermuly RT, Pullamsetti SS

Pro-proliferative and inflammatory signaling converge on FoxO1 transcription factor in pulmonary hypertension.

Nat Med. 2014 Nov;20(11):1289-300

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Conrad T, Marsico A, Gehre M, Orom UA

Microprocessor activity controls differential miRNA biogenesis In Vivo.

Cell Rep. 2014 Oct 23;9(2):542-54

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Becker MO, Kill A, Kutsche M, Guenther J, Rose A, Tabeling C, Witzenrath M, Kühl AA, Heidecke H, Ghofrani HA, Tiede H, Nickel N, Hoeper MM, Lukitsch I, Gollasch M, Kuebler WM, Bock S, Burmester GR, Dragun D, Riemekasten G

Vascular receptor autoantibodies in pulmonary arterial hypertension associated with systemic sclerosis.

Am J Respir Crit Care Med. 2014 Oct 1;190(7):808-17

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Czikora I, Alli A, Bao HF, Kaftan D, Sridhar S, Apell HJ, Gorshkov B, White R, Zimmermann A, Wendel A, Pauly-Evers M, Hamacher J, Garcia-Gabay I, Fischer B, Verin A, Bagi Z, Pittet JF, Shabbir W, Lemmens-Gruber R, Chakraborty T, Lazrak A, Matthay MA, Eaton DC, Lucas R

A novel tumor necrosis factor-mediated mechanism of direct epithelial sodium channel activation.

Am J Respir Crit Care Med. 2014 Sep 1;190(5):522-32

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Noe E, Tabeling C, Doehn JM, Naujoks J, Opitz B, Hippenstiel S, Witzenrath M, Klopfleisch R

Juvenile megaesophagus in PKCα-deficient mice is associated with an increase in the segment of the distal esophagus lined by smooth muscle cells.

Ann Anat. 2014 Sep;196(5):365-71

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Veith NT, Tschernig T, Gutbier B, Witzenrath M, Meier C, Menger M, Bischoff M

Surfactant protein A mediates pulmonary clearance of Staphylococcus aureus.

Respir Res. 2014 Aug 5;15:85

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Heine G, Tabeling C, Hartmann B, González Calera CR, Kühl AA, Lindner J, Radbruch A, Witzenrath M, Worm M

25-hydroxvitamin D3 promotes the long-term effect of specific immunotherapy in a murine allergy model.

J Immunol. 2014 Aug 1;193(3)

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Dietert K, Reppe K, Mundhenk L, Witzenrath M, Gruber A

mCLCA3 Modulates IL-17 and CXCL-1 Induction and Leukocyte Recruitment in Murine Staphylococcus aureus Pneumonia

PLoS One. 2014 Jul 17;9(7)

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Czikora I, Sridhar S, Gorshkov B, Alieva IB, Kasa A, Gonzales J, Potapenko O, Umapathy NS, Pillich H, Rick FG, Block NL, Verin AD, Chakraborty T, Mattay MA, Schally AV, Lucas R.

Protective effect of growth hormone-releasing hormone agonist in bacterial toxin-induced pulmonary barrier dysfunction.

Front Physiol. 2014; 5:259.

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Witzenrath M

Endothelial progenitor cells for acute respiratory distress syndrome treatment: support your local sheriff!

Am J Respir Crit Care Med. 2014 Jun 15;189(12):1452-5

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Deckmann K, Filipski K, Krasteva-Christ G, Fronius M, Althaus M, Rafiq A, Papadakis T, Renno L, Jurastow I, Wessels L, Schütz B, Weihe E, Chubanov V, Gudermann T, Klein J, Bschleipfer T, Kummer W

Bitter triggers acetylcholine release from polymodal urethral chemosensory cells and bladder reflexes.

Bitter triggers acetylcholine release from polymodal urethral chemosensory cells and bladder reflexes.

www.ncbi.nlm.nih.gov/pubmed/24843119

Weissmann N, Peters DM, Klöpping C, Krüger K, Pilat C, Katta S, Seimetz M, Ghofrani HA, Schermuly RT, Witzenrath M, Seeger W, Grimminger F, Mooren FC

Structural and functional prevention of hypoxia-induced pulmonary hypertension by individualized exercise training in mice.

Am J Physiol Lung Cell Mol Physiol. 2014 Jun 1;306(11):L986-95

www.ncbi.nlm.nih.gov/pubmed/24705723

Zakrzewicz D, Didiasova M, Zakrzewicz A, Hocke AC, Uhle F, Markart P, Preissner KT, Wygrecka M

The interaction of enolase-1 with caveolae-associated proteins regulates its subcellular localization.

Biochem J. 2014 Jun 1;460(2):295-307

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Tabeling C, Scheer H, Schönrock SM, Runge F, Gutbier B, Lienau J, Hamelmann E, Opitz B, Suttorp N, Mayer K, Behrens GM, Tschernig T, Witzenrath M

Nucleotide oligomerization domain 1 ligation suppressed murine allergen-specific T-cell proliferation and airway hyperresponsiveness.

Am J Respir Cell Mol Biol. 2014 May;50(5):903-11

www.ncbi.nlm.nih.gov/pubmed/24279792

Hecker M, Ott J, Sondermann C, Schaefer M, Obert M, Hecker A, Morty RE, Vadasz I, Herold S, Rosengarten B, Witzenrath M, Seeger W, Mayer K

Immunomodulation by fish-oil containing lipid emulsions in murine acute respiratory distress syndrome.

Crit Care. 2014 Apr 29;18(2):R85

www.ncbi.nlm.nih.gov/pubmed/24780004

Müller-Redetzky HC, Will D, Hellwig K, Kummer W, Tschernig T, Pfeil U, Paddenberg R, Menger MD, Kershaw O, Gruber AD, Weissmann N, Hippenstiel S, Suttorp N, Witzenrath M

Mechanical ventilation drives lung injury and sepsis in pneumococcal pneumonia: protection by Adrenomedullin

Crit Care. 2014 Apr 14;18(2):R73

www.ncbi.nlm.nih.gov/pubmed/24731244

Krljanac B, Weih D, Jacobsen ID, Hu D, Koliesnik I, Reppe K, Witzenrath M, Weih F.

NF-κB2/p100 deficiency impairs immune responses to T-cell-independent type 2 antigens.

Eur J Immunol. 2014 Mar;44(3):662-72

www.ncbi.nlm.nih.gov/pubmed/24242887

Müller-Redetzky HC, Suttorp N, Witzenrath M

Dynamics of pulmonary endothelial barrier function in acute inflammation: mechanisms and therapeutic perspectives.

Cell Tissue Res. 2014 Mar;355(3):657-73

www.ncbi.nlm.nih.gov/pubmed/24599335

Kill A, Tabeling C, Undeutsch R, Kühl AA, Günther J, Radic M, Becker MO, Heidecke H, Worm M, Witzenrath M, Burmester GR, Dragun D, Riemekasten G

Autoantibodies to angiotensin and endothelin receptors in systemic sclerosis induce cellular and systemic events associated with disease pathogenesis.

Arthritis Res Ther. 2014 Jan 28;16(1):R29

www.ncbi.nlm.nih.gov/pubmed/24472528

Peters DM, Vadász I, Wujak L, Wygrecka M, Olschewski A, Becker C, Herold S, Papp

TGF-ß directs trafficking of the epithelial sodium channel ENaC which has implications for ion and fluid transport in acute lung injury.

Proc Natl Acad Sci U S A. 2014 Jan 21;111(3):E374-83

www.ncbi.nlm.nih.gov/pubmed/24324142

Herold S, Hoegner K, Vadász I, Gessler T, Wilhelm J, Mayer K, Morty RE, Walmrath

Inhaled GM-CSF as treatment of pneumonia-associated ARDS

Am J Respir Crit Care Med. 2014 Mar 1;189(5):609-11

Malczyk M, Veith C, Fuchs B, Hofmann K, Storch U, Schermuly RT, Witzenrath M, Ah

Classical Transient Receptor Potential Channel 1 in Hypoxia-induced Pulmonary Hypertension.

Am J Respir Crit Care Med. 2013 Dec 15;188(12):1451-9.

www.ncbi.nlm.nih.gov/pubmed/24251695

Schütz F, Hackstein H

Identification of novel dendritic cell subset markers in human blood.

Biochem Biophys Res Commun. 2013 Dec 7. pii: S0006-291X(13)02024-X. doi: 10.1016/j.bbrc.2013.11.112.

www.ncbi.nlm.nih.gov/pubmed/24321550

Witsch TJ, Turowski P, Sakkas E, Niess G, Becker S, Herold S, Mayer K, Vadász I, Roberts JD Jr, Seeger W, Morty RE.

Deregulation of the lysyl hydroxylase matrix cross-linking system in experimental and clinical bronchopulmonary dysplasia.

Am J Physiol Lung Cell Mol Physiol. 2013 Nov 27.

www.ncbi.nlm.nih.gov/pubmed/24285264

Tabeling C, Scheer H, Schönrock SM, Runge F, Gutbier B, Lienau J, Hamelmann E, Opitz B, Suttorp N, Mayer K, Behrens GM, Tschernig T, Witzenrath M.

NOD1 Ligation Suppressed Murine Allergen-Specific T Cell Proliferation and Airway Hyperresponsiveness.

Am J Respir Cell Mol Biol. 2013 Nov 26.

www.ncbi.nlm.nih.gov/pubmed/24279792

Schulz R, Murzabekova G, Egemnazarov B, Kraut S, Eisele HJ, Dumitrascu R, Heitmann J, Seimetz M, Witzenrath M, Ghofrani HA, Schermuly RT, Grimminger F, Seeger W, Weissmann N.

Arterial hypertension in a murine model of sleep apnea: role of NADPH oxidase 2.

J Hypertens. 2013 Nov 21.

www.ncbi.nlm.nih.gov/pubmed/24270180

Naujoks J, Opitz B

Bacterial infections and the DNA sensing pathway

Bookchapter DNA Sensing: The impact of dsDNA on Disease and Vaccinology. Edited by Ken Ishii and Jason C.K. Tang; Elsevier

store.elsevier.com/Biological-DNA-Sensor/isbn-9780124047327

Chaput C, Sander LE, Suttorp N, Opitz B

NOD-Like Receptors in Lung Diseases.

Front Immunol. 2013, 4, 393.

www.ncbi.nlm.nih.gov/pubmed/24312100

Mukhametshina RT, Ruhs A, Singh I, Hasan D, Contreras A, Mehta A, Nikam VS, Ahlbrecht K, Carraro G, Cabrera-Fuentes HA, Jiang D, Voswinckel R, Seeger W, Bellusci S, Scharffetter-Kochanek K, Bagaeva TV, Preissner KT, Boettger T, Braun T, Krüger M, Barreto

Quantitative Proteome Analysis of Alveolar Type-II Cells Reveals a Connection of Integrin Receptor Subunits Beta 2/6 and WNT Signaling.

J Proteome Res. 2013 Dec 6;12(12):5598-608. doi: 10.1021/pr400573k. Epub 2013 Nov 18.

www.ncbi.nlm.nih.gov/pubmed/24175614

Schwartze JT, Becker S, Sakkas E, Wujak LA, Niess G, Usemann J, Reichenberger F, Herold S, Vadasz I, Mayer K, Seeger W, Morty RE.

Glucocorticoids recruit Tgfbr3 and Smad1 to shift transforming growth factor-ß signaling from the Tgfbr1/Smad2/3 axis to the Acvrl1/Smad1 axis in lung fibroblasts.

J Biol Chem. 2013 Dec 17

www.ncbi.nlm.nih.gov/pubmed/24347165

Knepper J, Schierhorn KL, Becher A, Budt M, Tönnies M, Bauer TT, Schneider P, Neudecker J, Rückert JC, Gruber AD, Suttorp N, Schweiger B, Hippenstiel S, Hocke AC, Wolff T

The novel human influenza A(H7N9) virus is naturally adapted to efficient growth in human lung tissue

MBio. 2013 Oct 8;4(5). pii: e00601-13. doi: 10.1128/mBio.00601-13.

www.ncbi.nlm.nih.gov/pubmed/24105764

Hocke AC, Becher A, Knepper J, Peter A, Holland G, Tönnies M, Bauer TT, Schneider P, Neudecker J, Muth D, Wendtner CM, Rückert JC, Drosten C, Gruber AD, Laue M, Suttorp N, Hippenstiel S, Wolff T.

Emerging Human Middle East Respiratory Syndrome Coronavirus Causes Widespread Infection and Alveolar Damage in Human Lungs.

Am J Respir Crit Care Med. 2013 Oct 1;188(7):882-886.

www.ncbi.nlm.nih.gov/pubmed/24083868

Grzesik BA, Vohwinkel C, Morty RE, Mayer K, Herold S, Seeger W, Vadász I

Efficient gene delivery to primary alveolar epithelial cells by nucleofection.

Am J Physiol Lung Cell Mol Physiol 2013, 305: 786-94

www.ncbi.nlm.nih.gov/pubmed/24077946

Hackstein H, Kranz S, Lippitsch A, Wachtendorf A, Kershaw O, Gruber AD, Michel G, Lohmeyer J, Bein G, Baal N, Herold S.

Modulation of respiratory dendritic cells during Klebsiella pneumonia infection.

Resp Res 2013 Sept 17;14(1):91 [Epub ahead of print].

www.ncbi.nlm.nih.gov/pubmed/24044871

Herold S, Gabrielli NM, Vadasz I.

Novel concepts of acute lung injury and alveolo-capillary barrier dysfunction.

Am J Physiol Lung Cell Mol Physiol. 13 Sept 2013, DOI: 10.1152/ajplung.00232.2013

www.ncbi.nlm.nih.gov/pubmed/24039257

Bayat B, Tjahjono Y, Sydykov A, Werth S, Hippenstiel S, Weissmann N, Sachs UJ, Santoso S.

Anti-Human Neutrophil Antigen-3a Induced Transfusion-Related Acute Lung Injury in Mice by Direct Disturbance of Lung Endothelial Cells.

Arterioscler Thromb Vasc Biol. 2013 Sep 12. [Epub ahead of print]

www.ncbi.nlm.nih.gov/pubmed/24008160

Bakr A, Pak O, Taye A, Hamada F, Hemeida R, Janssen W, Gierhardt M, Ghofrani HA, Seeger W, Grimminger F, Schermuly RT, Witzenrath M, Brandes RP, Huang N, Cooke JP, Weissmann N, Sommer N.

Effects of dimethylarginine dimethylaminohydrolase-1 overexpression on the response of the pulmonary vasculature to hypoxia

Am J Respir Cell Mol Biol. 2013 Sep;49(3):491-500

www.ncbi.nlm.nih.gov/pubmed/23642043

Marsico A, Huska MR, Lasserre J, Hu H, Vucicevic D, Musahl A, Orom UA, Vingron M.

PROmiRNA: a new miRNA promoter recognition method uncovers the complex regulation of intronic miRNAs.

Genome Biol. 2013 Aug 16;14(8)

genomebiology.com/2013/14/8/R84

Lucas R, Czikora I, Sridhar S, Zemskov EA, Oseghale A, Circo S, Cederbaum SD, Chakraborty T, Fulton DJ, Caldwell RW, Romero MJ.

Arginase 1: an unexpected mediator of pulmonary capillary barrier dysfunction in models of acute lung injury.

Front Immunol. 2013, 4:228

www.ncbi.nlm.nih.gov/pubmed/23966993

von Deetzen MC, Schmeck B, Gruber AD, Klopfleisch R.

Molecular quantification of canine specific microRNA species.

Res Vet Sci. 2013 Oct;95(2):562-8. Epub 2013 Jul 22.

www.ncbi.nlm.nih.gov/pubmed/23886399

Lucas R, Czikora I, Sridhar S, Zemskov E, Gorshkov B, Siddaramappa U, Oseghale A, Lawson J, Verin A, Rick FG, Block NL, Pillich H, Romero M, Leustik M, Schally AV, Chakraborty T.

Mini-review: Novel therapeutic strategies to blunt actions of pneumolysin in the lungs.

Toxins (Basel). 2013, 5:1244-1260.

www.ncbi.nlm.nih.gov/pubmed/23860351

Fulde M, Bernardo-García N, Rohde M, Nachtigall N, Frank R, Preissner KT, Klett J, Morreale A, Chhatwal GS, Hermoso JA, Bergmann S.

Pneumococcal phosphoglycerate kinase interacts with plasminogen and its tissue activator.

Thromb Haemost. 2013 Nov 7;111(3). [Epub ahead of print]

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Sittka A, Schmeck B.

MicroRNAs in the lung.

Adv Exp Med Biol. 2013;774:121-34. doi: 10.1007/978-94-007-5590-1_7. Review.

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Zahlten J, Steinicke R, Bertrams W, Hocke AC, Scharf S, Schmeck B, Witzenrath M, Hammerschmidt S, Suttorp N, Hippenstiel S.

TLR9- and Src-dependent expression of Krueppel-like factor 4 controls interleukin-10 expression in pneumonia.

Eur Respir J. 2013 Feb;41(2):384-91. Epub 2012 May 31

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Hecker M, Sommer N, Voigtmann H, Pak O, Mohr A, Wolf M, Vadász I, Herold S, Weissmann N, Morty R, Seeger W, Mayer K.

Impact of Short- and Medium-Chain Fatty Acids on Mitochondrial Function in Severe Inflammation.

JPEN J Parenter Enteral Nutr. 2013 May 23.

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Jaax ME, Krauel K, Marschall T, Brandt S, Gansler J, Fürll B, Appel B, Fischer S, Block S, Helm CA, Müller S, Preissner KT, Greinacher A

Complex formation with nucleic acids and aptamers alters the antigenic properties of platelet factor 4

Blood. 2013, 122, 272-81

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Doehn JM, Fischer K, Reppe K, Gutbier B, Tschernig T, Hocke AC, Fischetti VA, Löffler J, Suttorp N, Hippenstiel S, Witzenrath M.

Delivery of the endolysin Cpl-1 by inhalation rescues mice with fatal pneumococcal pneumonia.

J Antimicrob Chemother. 2013 Sep;68(9):2111-7. doi: 10.1093/jac/dkt131. Epub 2013 Apr 30.

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Ulm C, Saffarzadeh M, Mahavadi P, Müller S, Prem G, Saboor F, Simon P, Middendorff R, Geyer H, Henneke I, Bayer N, Rinné S, Lütteke T, Böttcher-Friebertshäuser E, Gerardy-Schahn R, Schwarzer D, Mühlenhoff M, Preissner KT, Günther A, Geyer R, Galuska SP

Soluble polysialylated NCAM: a novel player of the innate immune system in the lung

Cell Mol Life Sci. 2013 Oct;70(19):3695-708. doi: 10.1007/s00018-013-1342-0. Epub 2013 Apr 26

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Helbig ET, Opitz B, Sander LE

Adjuvant immunotherapies as a novel approach to bacterial infections

Immunotherapy. 2013;5, 365-81.

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Ebstein F, Voigt A, Lange N, Warnatsch A, Schröter F, Prozorovski T, Kuckelkorn U, Aktas O, Seifert U, Kloetzel PM, Krüger E

Immunoproteasomes are important for proteostasis in immune responses.

Cell 152, 935-7 (2013)

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Hocke AC, Berg J, Becher A, Knepper J, Klauschen F, Tönnies M, Bauer TT, Schneider P, Neudecker J, Rückert JC, Gruber AD, Suttorp N, Hippenstiel S, Wolff T.

Reply to Fujino et al.

J Infect Dis. 2013 Feb 15;207(4):693-5. doi: 10.1093/infdis/jis740. Epub 2012 Nov 29.

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Högner, K., Wolff, T., Pleschka, S.  Plog, S., Gruber, A.D., Kalinke, U., Walmrath, H.D., Bodner, J., Gattenlöhner, S., Lewe-Schlosser, P., Matrosovich, M., Seeger, W., Lohmeyer, J. and S. Herold

Macrophage-expressed IFN-ß contributes to apoptotic alveolar epithelial cell injury in severe influenza virus pneumonia.

PLoS Pathog. 2013 Feb;9(2), Epub 2013 Feb 28

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Hetze S, Engel O, Römer C, Mueller S, Dirnagl U, Meisel C, Meisel A.

Superiority of preventive antibiotic treatment compared with standard treatment of poststroke pneumonia in experimental stroke: a bed to bench approach

J Cereb Blood Flow Metab. 2013 Jan 30. doi: 10.1038/jcbfm.2013.6. [Epub ahead of print]

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Saffarzadeh, M. and Preissner, K.T.,

Fighting against the dark side of neutrophil extracellular traps in disease: manoeuvres for host protection.

Curr Opin Hematol. 2013, 20, 3-9.

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Fischer, S. and Preissner, K.T.,

Extracellular nucleic acids as novel alarm signals in the vascular system. Mediators of defence and disease.

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Am J Physiol Lung Cell Mol Physiol. 2010, 299(2): L272-L280

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Bachem A, Güttler S, Hartung E, Ebstein F, Schäfer M, Tannert A, Salama A, Mavassaghi K, Opitz C, Mages HW, Henn V, Kloetzel PM, Gurka S, Kroczek R

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J Exp Med 207, 1273-81 (2010)

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Am J Physiol Lung Cell Mol Physiol. 2010 May;298(5):L687-95. Epub 2010 Feb 12.

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Pulm Pharmacol Ther. 2010 Aug;23(4):334-44. Epub 2010 Apr 1.

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Essential role of mitochondrial antiviral signaling, IFN regulatory factor (IRF)3, and IRF7 in Chlamydophila pneumoniae-mediated IFN-beta response and control of bacterial replication in human endothelial cells.

J Immunol. 2010 Mar 15;184(6):3072-8. Epub 2010 Feb 12.

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Eur Respir J. 2010 Mar;35(3):598-605. Epub 2009 Aug 13.

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PLoS One. 2010 Jan 18;5(1):e8747.

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Listeria monocytogenes-infected human peripheral blood mononuclear cells produce IL-1beta,depending on listeriolysin O and NLRP3.

J Immunol. 2010 Jan 15;184(2):922-30. Epub 2009 Dec 11.

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