Transregio SFB-TR 84 “Innate Immunity of the Lung: Mechanisms of Pathogen Attack and Host Defence in Pneumonia“

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Publications

Scheller N, Herold S, Kellner R, Bertrams W, Jung AL, Janga H, Greulich T, Schulte LN, Vogelmeier CF, Lohmeyer J, Schmeck B.

Pro-viral miRNAs detected in BALF extracellular vesicles of patients with influenza virus-induced ARDS.

J Infect Dis. 2018 Sep 15

www.ncbi.nlm.nih.gov/pubmed/30239899

Robak OH, Heimesaat MM, Kruglov AA, Prepens S, Ninnemann J, Gutbier B, Reppe K, Hochrein H, Suter M, Kirschning CJ, Marathe V, Buer J, Hornef MW, Schnare M, Schneider P, Witzenrath M, Bereswill S, Steinhoff U, Suttorp N, Sander LE, Chaput C, Opitz B

Antibiotic treatment-induced secondary IgA deficiency enhances susceptibility to Pseudomonas aeruginosa pneumonia.

J Clin Invest. 2018 Jul 16. pii: 97065

www.jci.org/articles/view/97065

Herta T, Bhattacharyya A, Bollensdorf C, Kabus C, García P, Suttorp N, Hippenstiel S, Zahlten J

DNA-release by Streptococcus pneumoniae autolysin LytA induced Krueppel-like factor 4 expression in macrophages.

Sci Rep. 2018 Apr 10;8(1):5723

www.ncbi.nlm.nih.gov/pubmed/29636524

Erickson NA, Dietert K, Enders J, Glauben R, Nouailles G, Gruber AD, Mundhenk L

Soluble mucus component CLCA1 modulates expression of leukotactic cytokines and BPIFA1 in murine alveolar macrophages but not in bone marrow-derived macrophages.

Histochem Cell Biol. 2018 Apr 2. doi: 10.1007/s00418-018-1664-y

www.ncbi.nlm.nih.gov/pubmed/29610986

Schumann B, Reppe K, Kaplonek P, Wahlbrink A, Anish C, Witzenrath M, Pereira CL, Seeberger PH

Development of an Efficacious, Semisynthetic Glycoconjugate Vaccine Candidate against Streptococcus pneumoniae Serotype 1.

ACS Cent Sci. 2018 4,357-361.

www.ncbi.nlm.nih.gov/pubmed/29632881

Barbet G, Sander LE, Geswell M, Leonardi I, Cerutti A, Iliev I, Blander JM

Sensing Microbial Viability through Bacterial RNA Augments T Follicular Helper Cell and Antibody Responses.

Immunity 2018;48(3):584-598.e5

www.cell.com/immunity/pdfExtended/S1074-7613(18)30074-8

Ugolini M, Gerhard J, Burkert S, Jensen KJ, Georg P, Ebner F, Thada S, Dietert K, Helbig ET, Opitz B, Kurth F, Dittrich N, Sumanlatha G, Blander JM, Gruber AD, Hartmann S, Boekschoten MV, Suttorp N, Müller M, Jungersen G, Schumann RR, Sander LE

Recognition of microbial viability via TLR8 promotes T follicular helper cell differentiation and vaccine responses.

Nat Immunol  2018

www.nature.com/articles/s41590-018-0068-4

Schulte LN, Heinrich B, Janga H, Schmeck BT, Vázquez O

A Far-Red Fluorescent DNA Binder for Interaction Studies of Live Multidrug-Resistant Pathogens and Host.

Cells. Angew Chem Int Ed Engl. 2018 Sep 3;57(36):11564-11568

www.ncbi.nlm.nih.gov/pubmed/29972713

Janga H, Aznaourova M, Boldt F, Damm K, Grünweller A, Schulte LN

Cas9-mediated excision of proximal DNaseI/H3K4me3 signatures confers robust silencing of microRNA and long non-coding RNA genes.

PLoS One. 2018 Feb 16;13(2)

journals.plos.org/plosone/article

Gutbier B, Neuhauß AK, Reppe K, Ehrler C, Santel A, Kaufmann J, Scholz M, Weissmann N, Morawietz L, Mitchell TJ, Aliberti S, Hippenstiel S, Suttorp N, Witzenrath M; CAPNETZ and PROGRESS study groups

Prognostic and Pathogenic Role of Angiopoietin-1 and -2 in Pneumonia.

Am J Respir Crit Care Med. 2018 Feb 15

www.ncbi.nlm.nih.gov/pubmed/29447449

Dietert K, Nouailles G, Gutbier B, Reppe K, Berger S, Jiang X, Schauer AE, Hocke AC, Herold S, Slevogt H, Witzenrath M, Suttorp N, Gruber AD

Digital Image Analyses on Whole Lung Slides in Mouse Models of Acute Pneumonia.

Am J Respir Cell Mol Biol. 2018 Jan 23.

www.atsjournals.org/doi/full/10.1165/rcmb.2017-0337MA

Nerlich A, Mieth M, Letsiou E, Fatykhova D, Zscheppang K, Matsushima AI, Meyer TF, Paasch L, Mitchell T, Tönnies M, Bauer TT, Schneider P, Neudecker J, Rückert J, Eggeling S, Schimek M, Witzenrath M, Suttorp N, Hippenstiel S, Hocke AC

Pneumolysin induced mitochondrial dysfunction leads to release of mitochondrial DNA.

Scientific Reports (2018) 8:182

www.nature.com/articles/s41598-017-18468-7

Ruiz-Moreno JS, Hamann L, Shah JA, Verbon A, Mockenhaupt FP, Puzianowska-Kuznicka M, Naujoks J, Sander LE, Witzenrath M, Cambier JC, Suttorp N, Schumann RR, Jin L, Hawn TR,  Opitz B,  CAPNETZ Study Group

The common HAQ STING variant impairs cGAS-dependent antibacterial responses and is associated with susceptibility to Legionnaires' disease in humans.

PLoS Pathog. 2018 Jan 3;14(1)

journals.plos.org/plospathogens/article

Gutbier B, Schönrock SM, Ehrler C, Haberberger R, Dietert K, Gruber AD, Kummer W, Michalik L, Kübler WM, Hocke AC, Szymanski K, Letsiou E, Lüth A, Schumacher F, Kleuser B, Mitchell TJ, Bertrams W, Schmeck B, Treue D, Klauschen F, Bauer TT, Tönnies M, Weissmann N, Hippenstiel S, Suttorp N, Witzenrath M, CAPNETZ Study Group

Sphingosine kinase 1 regulates inflammation and contributes to acute lung injury in pneumococcal pneumonia via the S1P receptor 2.

Crit Care Med. 2018 Jan 2.

www.ncbi.nlm.nih.gov/pubmed/29298188

Ruiz-Moreno JS, Hamann L, Jin L, Sander LE, Puzianowska-Kuznickad M, Cambier JC, Witzenrath M, Schumann RR, Suttorp N, Opitz B, CAPNETZ Study Group

The cGAS/STING pathway detects Streptococcus pneumoniae but is dispensable for anti-pneumococcal defense in mice and humans.

Infect Immun. 2017 Dec 20. pii: IAI.00849-17

iai.asm.org/content/early/2017/12/13/IAI.00849-17.abstract

Fischer S, Noll, F, Behnke J, Leitling S, Troidl K, Teixeira Alves G, Preissner, KT

Self-extracellular RNA acts in synergy with exogenous danger signals to promote inflammation.

PLoS One. 2017 Dec 20;12(12):e0190002

doi.org/10.1371/journal.pone.0190002

Jensen AV, Faurholt-Jepsen D, Egelund GB, Andersen SB, Petersen PT, Benfield T, Witzenrath M, Rohde G, Ravn P; German Community-Acquired Pneumonia Competence Network (CAPNETZ)

Undiagnosed Diabetes Mellitus in Community-Acquired Pneumonia: A Prospective Cohort Study.

Clin Infect Dis. 2017 Nov 29;65(12):2091-2098

academic.oup.com/cid/article/65/12/2091/4582709

Dietert K, Gutbier B, Wienhold SM, Reppe K, Jiang X, Yao L, Chaput C, Naujoks J, Brack M, Kupke A, Peteranderl C, Becker S, von Lachner C, Baal N, Slevogt H, Hocke AC, Witzenrath M, Opitz B, Herold S, Hackstein H, Sander LE, Suttorp N, Gruber AD

Spectrum of pathogen- and model-specific histopathologies in mouse models of acute pneumonia.

PLoS One. 2017 Nov 20;12(11):e0188251

www.ncbi.nlm.nih.gov/pubmed/29155867

Gutbier B, Jiang X, Dietert K, Ehrler C, Lienau J, Van Slyke P, Kim H, Van Hoang C, Maynes JT, Dumont DJ, Gruber AD, Weissmann N, Mitchell TJ, Suttorp N, Witzenrath M

Vasculotide reduces pulmonary hyperpermeability in experimental pneumococcal pneumonia.

Critical Care 2017 Nov 13;21(1):274

www.ncbi.nlm.nih.gov/pubmed/29132435

Emmadi M, Khan N, Lykke L, Reppe K, Parameswarappa S, Lisboa MP, Wienhold SM, Witzenrath M, Pereira CL, Seeberger PH

A Streptococcus pneumoniae type 2 oligosaccharide glycoconjugate elicits opsonic antibodies and is protective in an animal model of invasive pneumococcal disease.

J Am Chem Soc 2017 Oct 4 [Epub ahead of print]

www.ncbi.nlm.nih.gov/pubmed/28945368

Lisboa MP, Khan N, Martin C, Xu FF, Reppe K, Geissner A, Govindan S, Witzenrath M, Pereira CL, Seeberger PH

Semisynthetic glycoconjugate vaccine candidate against Streptococcus pneumoniae serotype 5.

Proc Natl Acad Sci USA 2017 Oct 2 [Epub ahead of print]

www.ncbi.nlm.nih.gov/pubmed/28973947

Schulz C, Lai X, Bertrams W, Jung AL, Sittka-Stark A, Herkt CE, Janga H, Zscheppang K, Stielow C, Schulte L, Hippenstiel S, Vera J, Schmeck B

THP-1-derived macrophages render lung epithelial cells hypo-responsive to Legionella pneumophila - a systems biology study.

Sci Rep. 2017 Sep 20;7(1):11988

www.ncbi.nlm.nih.gov/pubmed/28931863

Seeberger PH, Pereira CL, Khan N, Xiao G, Diago-Navarro E, Reppe K, Opitz B, Fries BC, Witzenrath M

A semi-synthetic glycoconjugate vaccine candidate for carbapenem-resistant Klebsiella pneumoniae.

Angew Chem Int Ed Engl. 2017 Aug 16

www.pubmed.de/gateway/nlm-pubmed/28815890

Jung AL, Herkt CE, Schulz C, Bolte K, Seidel K, Scheller N, Sittka-Stark A, Bertrams W, Schmeck B

Legionella pneumophila infection activates bystander cells differentially by bacterial and host cell vesicles.

Sci Rep. 2017 Jul 24;7(1):6301

www.ncbi.nlm.nih.gov/pubmed/28740179

Wygrecka M, Kosanovic D, Wujak L, Reppe K, Henneke I, Frey H, Didiasova M, Kwapiszewska G, Marsh LM, Baal N, Hackstein H, Zakrzewicz D, Müller-Redetzky HC, de Maat S, Maas C, Nolte MW, Panousis C, Schermuly RT, Seeger W, Witzenrath M, Schaefer L, Markart P

Antihistone Properties of C1 Esterase Inhibitor Protect against Lung Injury.

Am J Respir Crit Care Med. 2017 Jul 15;196(2):186-199

www.ncbi.nlm.nih.gov/pubmed/28005404

Tabeling C, Herbert J, Hocke AC, Lamb DJ, Wollin SL, Erb KJ, Boiarina E, Movassagh H, Scheffel J, Doehn JM, Hippenstiel S, Maurer M, Gounni AS, Kuebler WM, Suttorp N, Witzenrath M

Spleen tyrosine kinase inhibition blocks airway constriction and protects from Th2-induced airway inflammation and remodeling.

Allergy. 2017 Jul;72(7):1061-1072

www.ncbi.nlm.nih.gov/pubmed/ 27906453

Schaefer MB, Schaefer CA, Hecker M, Morty RE, Witzenrath M, Seeger W, Mayer K

Co-incubation of PMN and CaCo-2 cells modulates inflammatory potential.

Cell Mol Biol (Noisy-le-grand) 2017; 63:119-126

www.ncbi.nlm.nih.gov/pubmed/28719356

Jentho E, Bodden M, Schulz C, Jung AL, Seidel K, Schmeck B, Bertrams W

microRNA-125a-3p is regulated by MyD88 in Legionella pneumophila infection and targets NTAN1.

PLoS One. 2017 Apr 26;12(4):e0176204

www.ncbi.nlm.nih.gov/pubmed/28445535

Hahm HS, Schlegel MK, Hurevich M, Eller S, Schuhmacher F, Hofmann J, Pagel K, and Seeberger PH

Automated glycan assembly using the Glyconeer 2.1 synthesizer.

Proc Natl Acad Sci U S A 114: E3385-E3389, 2017

www.ncbi.nlm.nih.gov/pubmed/28396442

Schumann B, Hahm HS, Parameswarappa SG, Reppe K, Wahlbrink A, Govindan S, Kaplonek P, Pirofski LA, Witzenrath M, Anish C, Pereira CL, Seeberger PH

A semisynthetic Streptococcus pneumoniae serotype 8 glycoconjugate vaccine.

Sci Transl Med. 2017 Mar 8;9(380)

www.ncbi.nlm.nih.gov/pubmed/28275152

Wentker P, Eberhardt M, Dreyer FS, Bertrams W, Cantone M, Griss K, Schmeck B, Vera J

An Interactive Macrophage Signal Transduction Map Facilitates Comparative Analyses of High-Throughput Data.

J Immunol. 2017 Mar 1;198(5):2191

www.ncbi.nlm.nih.gov/pubmed/28137890

Jung AL, Hoffmann K, Herkt CE, Schulz C, Bertrams W, Schmeck B

Legionella pneumophila Outer Membrane Vesicles: Isolation and Analysis of Their Pro-inflammatory Potential on Macrophages.

J Vis Exp. 2017 Feb 22;(120)

www.jove.com/video/55146/legionella-pneumophila-outer-membrane-vesicles-isolation-analysis

Druzd D, Matveeva O, Ince L, Harrison U, He W, Schmal C, Herzel H, Tsang AH, Kawakami N, Leliavski A, Uhl O, Yao L, Sander LE, Chen CS, Kraus K, de Juan A, Hergenhan SM, Ehlers M, Koletzko B, Haas R, Solbach W, Oster H, Scheiermann C

Lymphocyte Circadian Clocks Control Lymph Node Trafficking and Adaptive Immune Responses.

Immunity. 2017 Jan 17;46(1):120-132

www.sciencedirect.com/science/article/pii/S1074761316305179

Parameswarappa SG, Reppe K, Geissner A, Ménová P, Govindan S, Calow AD, Wahlbrink A, Weishaupt MW, Monnanda BP, Bell RL, Pirofski LA, Suttorp N, Sander LE, Witzenrath M, Pereira CL, Anish C, Seeberger PH

A Semi-synthetic Oligosaccharide Conjugate Vaccine Candidate Confers Protection against Streptococcus pneumoniae Serotype 3 Infection.

Cell Chem Biol. 2016 Nov 2. pii: S2451-9456(16)30356-7

www.ncbi.nlm.nih.gov/pubmed/27818299

Schaefer MB, Schaefer CA, Schifferings S, Kuhlmann CR, Urban A, Benscheid U, Fischer T, Hecker M, Morty RE, Vadasz I, Herold S, Witzenrath M, Seeger W, Erdogan A, Mayer K

N-3 vs. n-6 fatty acids differentially influence calcium signalling and adhesion of inflammatory activated monocytes: impact of lipid rafts.

Inflamm Res. 2016 Nov;65(11):881-894

www.ncbi.nlm.nih.gov/pubmed/27384606

Garaude J, Acín-Pérez R, Martínez-Cano S, Enamorado M, Ugolini M, Nistal-Villán E, Hervás-Stubbs S, Pelegrín P, Sander LE, Enríquez JA, Sancho D

Mitochondrial respiratory-chain adaptations in macrophages contribute to antibacterial host defense.

Nat Immunol. 2016 Sep;17(9):1037-45

www.ncbi.nlm.nih.gov/pubmed/27348412

Du Bois I, Marsico A, Bertrams W, Schweiger MR, Caffrey BE, Sittka-Stark A, Eberhardt M, Vera J, Vingron M, Schmeck BT

Genome-wide Chromatin Profiling of Legionella pneumophila-Infected Human Macrophages Reveals Activation of the Probacterial Host Factor TNFAIP2.

J Infect Dis. 2016 Aug 1;214(3):454-63

www.ncbi.nlm.nih.gov/pubmed/27130431

Kostadinova E, Chaput C, Gutbier B, Lippmann J, Sander LE, Mitchell TJ, Suttorp N, Witzenrath M, Opitz B

NLRP3 protects alveolar barrier integrity by an inflammasome-independent increase of epithelial cell adherence

Sci Rep. 2016 Aug 1;6:30943

www.ncbi.nlm.nih.gov/pubmed/27476670

Budach S, Heinig M, Marsico A

Principles of microRNA Regulation Revealed Through Modeling microRNA Expression Quantitative Trait Loci.

Genetics. 2016 Aug;203(4):1629-40

www.ncbi.nlm.nih.gov/pubmed/27260304

Jung AL, Stoiber C, Herkt CE, Schulz C, Bertrams W, Schmeck B

Legionella pneumophila-derived outer membrane vesicles promote bacterial replication in macrophages.

PLoS Pathog. 2016 Apr 22;12(4)

www.ncbi.nlm.nih.gov/pubmed/27105429

Kirschner F, Reppe K, Andresen N, Witzenrath M, Ebstein F, Kloetzel PM

Proteasome β5i subunit deficiency affects opsonin synthesis and aggravates pneumococcal pneumonia

PLoS One. 2016 Apr 21;11(4):e0153847.

www.ncbi.nlm.nih.gov/pubmed/27100179

Griss K, Bertrams W, Sittka-Stark A, Seidel K, Stielow C, Hippenstiel S, Suttorp N, Eberhardt M, Wilhelm J, Vera J, Schmeck B

MicroRNAs constitute a negative feedback loop in Streptococcus pneumoniae induced macrophage activation.

J Infect Dis. 2016 Mar 16

www.ncbi.nlm.nih.gov/pubmed/26984146

Tabeling C, Noe E, Naujoks J, Doehn JM, Hippenstiel S, Opitz B, Suttorp N, Klopfleisch R, Witzenrath M

PKCα Deficiency in Mice Is Associated with Pulmonary Vascular Hyperresponsiveness to Thromboxane A2 and Increased Thromboxane Receptor Expression.

J Vasc Res. 2015;52(4):279-88

www.ncbi.nlm.nih.gov/pubmed/26890419

Naujoks J, Tabeling C, Dill BD, Hoffmann C, Brown AS, Kunze M, Kempa S, Peter A, Mollenkopf HJ, Dorhoi A, Kershaw O, Gruber AD, Sander LE, Witzenrath M, Herold S, Nerlich A, Hocke AC, van Driel I, Suttorp N, Bedoui S, Hilbi H, Trost M, Opitz B

IFNs Modify the Proteome of Legionella-Containing Vacuoles and Restrict Infection Via IRG1-Derived Itaconic Acid.

PLoS Pathog. 2016 Feb 1;12(2)

www.ncbi.nlm.nih.gov/pubmed/26829557

Reppe K, Radünzel P, Dietert K, Tschernig T, Wolff T, Hammerschmidt S, Gruber AD, Suttorp N, Witzenrath M

Pulmonary immunostimulation with MALP-2 in influenza virus-infected mice increases survival after pneumococcal superinfection.

Infect Immun. 2015 Dec;83(12):4617-29

www.ncbi.nlm.nih.gov/pubmed/26371127

Zahlten J, Herta T, Kabus C, Steinfeldt M, Kershaw O, García P, Hocke AC, Gruber AD, Hübner RH, Steinicke R, Doehn JM, Suttorp N, Hippenstiel S

Role of Pneumococcal Autolysin for KLF4 Expression and Chemokine Secretion in Lung Epithelium.

Am J Respir Cell Mol Biol. 2015 Oct;53(4):544-54

www.ncbi.nlm.nih.gov/pubmed/ 25756955

Müller-Redetzky H, Lienau J, Suttorp N, Witzenrath M

Therapeutic strategies in pneumonia: going beyond antibiotics.

Eur Respir Rev. 2015 Sep;24(137):516-24

www.ncbi.nlm.nih.gov/pubmed/26324814

Gutbier B, Fischer K, Doehn JM, von Lachner C, Herr C, Klaile E, Frischmann U, Singer BB, Riesbeck K, Zimmermann W, Suttorp N, Bachmann S, Bals R, Witzenrath M, Slevogt H

Moraxella catarrhalis induces an immune response in the murine lung that is independent of human CEACAM5 expression and long-term smoke exposure.

Am J Physiol Lung Cell Mol Physiol. 2015 Aug 1;309(3):L250-61

www.ncbi.nlm.nih.gov/pubmed/26047639

Hecker M, Linder T, Ott J, Walmrath HD, Lohmeyer J, Vadász I, Marsh LM, Herold S, Reichert M, Buchbinder A, Morty RE, Bausch B, Fischer T, Schulz R, Grimminger F, Witzenrath M, Barnes M, Seeger W, Mayer K

Immunomodulation by lipid emulsions in pulmonary inflammation: a randomized controlled trial.

Crit Care. 2015 May 12;19:226

www.ncbi.nlm.nih.gov/pubmed/25962383

Müller-Redetzky HC, Wienhold SM, Berg J, Hocke AC, Hippenstiel S, Hellwig K, Gutbier B, Opitz B, Neudecker J, Rückert J, Gruber AC, Kershaw O, Mayer K,  Suttorp N, Witzenrath M

Moxifloxacin is not anti-inflammatory in experimental pneumococcal pneumonia.

J Antimicrob Chemother. 2015 Mar;70(3):830-40

www.ncbi.nlm.nih.gov/pubmed/25406299

Tabeling C, Yu H, Wang L, Ranke H, Goldenberg NM, Zabini D, Noe E, Krauszman A, Gutbier B, Yin J, Schaefer M, Arenz C, Hocke AC, Suttorp N, Proia RL, Witzenrath M, Kuebler WM

CFTR and sphingolipids mediate hypoxic pulmonary vasoconstriction.

Proc Natl Acad Sci U S A. 2015 Mar 31;112(13):E1614-23

www.ncbi.nlm.nih.gov/pubmed/25829545

Zahlten J, Herta T, Kabus C, Steinfeldt M, Kershaw O, García P, Hocke AC, Gruber AD, Hübner RH, Steinicke R, Doehn JM, Suttorp N, Hippenstiel S

Pneumococci LytA-dependent KLF4 Expression Terminates IL-8 Secretion in Lung Epithelium.

Am J Respir Cell Mol Biol. 2015 Mar 10

www.ncbi.nlm.nih.gov/pubmed/25756955

Dietert K, Mundhenk L, Erickson NA, Reppe K, Hocke AC, Kummer W, Witzenrath M, Gruber AD

Murine CLCA5 is uniquely expressed in distinct niches of airway epithelial cells.

Histochem Cell Biol. 2015 Mar;143(3):277-87. doi: 10.1007/s00418-014-1279-x.

www.ncbi.nlm.nih.gov/pmc/articles/PMC4317516/

Cabrera-Fuentes HA, Lopez ML, McCurdy S, Fischer S, Meiler S, Baumer Y, Galuska SP, Preissner KT, Boisvert WA

Regulation of monocyte/macrophage polarisation by extracellular RNA.

Thromb Haemost. 2015 Mar;113(3):473-81

www.ncbi.nlm.nih.gov/pubmed/25589344

Rabes A, Zimmermann S, Reppe K, Lang R, Seeberger PH, Suttorp N, Witzenrath M, Lepenies B, Opitz B

The C-type lectin receptor Mincle binds to Streptococcus pneumoniae but plays a limited role in the anti-pneumococcal innate immune response.

PLoS One. 2015 Feb 6;10(2):e0117022

www.ncbi.nlm.nih.gov/pubmed/25658823

Müller-Redetzky HC, Felten M, Hellwig K, Wienhold SM, Naujoks J, Opitz B, Kershaw O, Gruber AD, Suttorp N, Witzenrath M

Increasing the inspiratory time and I:E ratio during mechanical ventilation aggravates ventilator-induced lung injury in mice.

Critical Care 2015, 19:23

www.ncbi.nlm.nih.gov/pubmed/25888164

Dames C, Akyüz L, Reppe K, Tabeling C, Dietert K, Kershaw O, Gruber AD, Meisel C, Meisel A, Witzenrath M, Engel O

Miniaturized bronchoscopy enables unilateral investigation, application, and sampling in mice.

Am J Respir Cell Mol Biol. 2014 Dec;51(6):730-7

www.ncbi.nlm.nih.gov/pubmed/24960575

Savai R, Al-Tamari HM, Sedding D, Kojonazarov B, Muecke C, Teske R, Capecchi MR, Weissmann N, Grimminger F, Seeger W, Schermuly RT, Pullamsetti SS

Pro-proliferative and inflammatory signaling converge on FoxO1 transcription factor in pulmonary hypertension.

Nat Med. 2014 Nov;20(11):1289-300

www.ncbi.nlm.nih.gov/pubmed/25344740

Conrad T, Marsico A, Gehre M, Orom UA

Microprocessor activity controls differential miRNA biogenesis In Vivo.

Cell Rep. 2014 Oct 23;9(2):542-54

www.ncbi.nlm.nih.gov/pubmed/25310978

Becker MO, Kill A, Kutsche M, Guenther J, Rose A, Tabeling C, Witzenrath M, Kühl AA, Heidecke H, Ghofrani HA, Tiede H, Nickel N, Hoeper MM, Lukitsch I, Gollasch M, Kuebler WM, Bock S, Burmester GR, Dragun D, Riemekasten G

Vascular receptor autoantibodies in pulmonary arterial hypertension associated with systemic sclerosis.

Am J Respir Crit Care Med. 2014 Oct 1;190(7):808-17

www.ncbi.nlm.nih.gov/pubmed/25181620

Noe E, Tabeling C, Doehn JM, Naujoks J, Opitz B, Hippenstiel S, Witzenrath M, Klopfleisch R

Juvenile megaesophagus in PKCα-deficient mice is associated with an increase in the segment of the distal esophagus lined by smooth muscle cells.

Ann Anat. 2014 Sep;196(5):365-71

www.ncbi.nlm.nih.gov/pubmed/24862691

Veith NT, Tschernig T, Gutbier B, Witzenrath M, Meier C, Menger M, Bischoff M

Surfactant protein A mediates pulmonary clearance of Staphylococcus aureus.

Respir Res. 2014 Aug 5;15:85

www.ncbi.nlm.nih.gov/pubmed/25091948

Heine G, Tabeling C, Hartmann B, González Calera CR, Kühl AA, Lindner J, Radbruch A, Witzenrath M, Worm M

25-hydroxvitamin D3 promotes the long-term effect of specific immunotherapy in a murine allergy model.

J Immunol. 2014 Aug 1;193(3)

www.ncbi.nlm.nih.gov/pubmed/24951815

Dietert K, Reppe K, Mundhenk L, Witzenrath M, Gruber A

mCLCA3 Modulates IL-17 and CXCL-1 Induction and Leukocyte Recruitment in Murine Staphylococcus aureus Pneumonia

PLoS One. 2014 Jul 17;9(7)

www.ncbi.nlm.nih.gov/pubmed/25033194

Witzenrath M

Endothelial progenitor cells for acute respiratory distress syndrome treatment: support your local sheriff!

Am J Respir Crit Care Med. 2014 Jun 15;189(12):1452-5

www.ncbi.nlm.nih.gov/pubmed/24930525

Weissmann N, Peters DM, Klöpping C, Krüger K, Pilat C, Katta S, Seimetz M, Ghofrani HA, Schermuly RT, Witzenrath M, Seeger W, Grimminger F, Mooren FC

Structural and functional prevention of hypoxia-induced pulmonary hypertension by individualized exercise training in mice.

Am J Physiol Lung Cell Mol Physiol. 2014 Jun 1;306(11):L986-95

www.ncbi.nlm.nih.gov/pubmed/24705723

Tabeling C, Scheer H, Schönrock SM, Runge F, Gutbier B, Lienau J, Hamelmann E, Opitz B, Suttorp N, Mayer K, Behrens GM, Tschernig T, Witzenrath M

Nucleotide oligomerization domain 1 ligation suppressed murine allergen-specific T-cell proliferation and airway hyperresponsiveness.

Am J Respir Cell Mol Biol. 2014 May;50(5):903-11

www.ncbi.nlm.nih.gov/pubmed/24279792

Hecker M, Ott J, Sondermann C, Schaefer M, Obert M, Hecker A, Morty RE, Vadasz I, Herold S, Rosengarten B, Witzenrath M, Seeger W, Mayer K

Immunomodulation by fish-oil containing lipid emulsions in murine acute respiratory distress syndrome.

Crit Care. 2014 Apr 29;18(2):R85

www.ncbi.nlm.nih.gov/pubmed/24780004

Müller-Redetzky HC, Will D, Hellwig K, Kummer W, Tschernig T, Pfeil U, Paddenberg R, Menger MD, Kershaw O, Gruber AD, Weissmann N, Hippenstiel S, Suttorp N, Witzenrath M

Mechanical ventilation drives lung injury and sepsis in pneumococcal pneumonia: protection by Adrenomedullin

Crit Care. 2014 Apr 14;18(2):R73

www.ncbi.nlm.nih.gov/pubmed/24731244

Krljanac B, Weih D, Jacobsen ID, Hu D, Koliesnik I, Reppe K, Witzenrath M, Weih F.

NF-κB2/p100 deficiency impairs immune responses to T-cell-independent type 2 antigens.

Eur J Immunol. 2014 Mar;44(3):662-72

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Arterioscler Thromb Vasc Biol. 2013 Sep 12. [Epub ahead of print]

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Genome Biol. 2013 Aug 16;14(8)

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Eur Respir J. 2013 Feb;41(2):384-91. Epub 2012 May 31

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JPEN J Parenter Enteral Nutr. 2013 May 23.

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J Antimicrob Chemother. 2013 Sep;68(9):2111-7. doi: 10.1093/jac/dkt131. Epub 2013 Apr 30.

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Immunoproteasomes are important for proteostasis in immune responses.

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Sittka A, Vera J, Lai X, Schmeck BT.

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Pediatr Res. 2013 Apr;73(4 Pt 2):543-52. doi: 10.1038/pr.2013.8. Epub 2013 Jan 11. Review.

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J Infect Dis. 2012 Dec 1;206(11):1685-94. Epub 2012 Jul 24

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Cell Mol Life Sci. 69, 2543-58 (2012)

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Exp Lung Res. 2012 Mar;38(2):100-10. doi: 10.3109/01902148.2011.652802.

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Curr Opin Immunol.24, 77-83 (2012)

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Eitel J, Meixenberger K, van Laak C, Orlovski C, Hocke A, Schmeck B, Hippenstiel S, N’Guessan PD, Suttorp N, Opitz B

Rac1 regulates the NLRP3 inflammasome which mediates IL-1beta production in Chlamydophila pneumoniae infected human mononuclear cells.

PLoS One. 2012;7(1):e30379. doi: 10.1371/journal.pone.0030379. Epub 2012 Jan 20.

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J Immunol. 2012 Jan 15;188(2):811-7

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Opitz E, Koch A, Klinge lK, Schmidt F, Prokop S, Rahnefeld A, Sauter M, Heppner FL, Völker U, Kandolf R, Kuckelkorn U, Stangl K, Krüger E, Kloetzel PM, Voigt A

Impairment of immunoproteasome function by ß5i/LMP7 subunit deficiency results in severe enterovirus myocarditis.

PLoS Pathog. 7, e1002233 (2011)

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Lippmann J, Müller H, Naujoks J, Tabeling C, Shin S, Witzenrath M, Hellwig K, Kirschning CJ, Taylor GA, Barchet W, Bauer S, Suttorp N, Roy CR, Opitz B

Dissection of a type I interferon pathway in controlling bacterial intracellular infection in mice.

Cell Microbiol. 2011 Nov;13(11):1668-82. doi: 10.1111/j.1462-5822.2011.01646.x. Epub 2011 Aug 24

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Müller HC, Hocke AC, Hellwig K, Gutbier B, Peters H, Schönrock SM, Tschernig T, Schmiedl A, Hippenstiel S, N´Guessan PD, Rosseau S, Suttorp N, Witzenrath M.

The Sphingosine-1 Phosphate receptor agonist FTY720 dose dependently affected endothelial integrity in vitro and aggravated ventilator-induced lung injury in mice.

Pulm Pharmacol Ther. 2011 Aug;24(4):377-85. doi: 10.1016/j.pupt.2011.01.017. Epub 2011 Mar 23.

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Witzenrath M, Pache F, Lorenz D, Koppe U, Schönrock S, Meixenberger K, Dorhoi A, Ma J, Holmes A, Trendelenburg G, Heimesaat MM, Bereswill S, van der Linden M, Tschopp J, Mitchell TJ, Suttorp N, Opitz B.

The NLRP3 Inflammasome is Differentially Activated by Pneumolysin Variants and Contributes to Host Defense in Pneumococcal Pneumonia.

J Immunol. 2011 Jul 1;187(1):434-40. Epub 2011 Jun 6.

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Pinto R, Herold S, Cakarova L, Hoegner K, Seeger W, Lohmeyer J, Planz O, Pleschka S

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Antiviral Res. 2011 Oct;92(1):45-56. Epub 2011 May 27

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Exudate macrophages attenuate epithelial injury by the release of IL-1 receptor antagonist in gram-negative pneumonia.

Am J Respir Crit Care Med. 2011 May 15;183(10):1380-90. doi: 10.1164/rccm.201009-1431OC. Epub 2011 Jan 28

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Müller HC, Witzenrath M, Tschernig T, Gutbier B, Hippenstiel S, Santel A, Suttorp N, Rosseau S.

Adrenomedullin attenuates ventilator-induced lung injury in mice.

Thorax. 2010 Dec;65(12):1077-84. Epub 2010 Oct 22

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Müller HC, Hellwig K, Rosseau S, Tschernig T, Schmiedl A, Gutbier B, Schmeck B, Hippenstiel S, Peters H, Morawietz L, Suttorp N, Witzenrath M.

Simvastatin attenuates ventilator-induced lung injury in mice.

Crit Care. 2010 14(4):R143. Epub 2010 Jul 30.

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Lorenz J, Zahlten J, Pollok I, Lippmann J, Scharf S, N´Guessan PD, Opitz B, Flieger A, Suttorp N, Hippenstiel S, Schmeck B.

Legionella pneumophila-induced I?B?-dependent expression of interleukin-6 in lung epithelium.

Eur Respir J. 2011 Mar;37(3):648-57. Epub 2010 Jul 22.

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Scharf S, Vardarova K, Lang F, Schmeck B, Opitz B, Flieger A, Heuner K, Hippenstiel S, Suttorp N, N´Guessan PD.

Legionella pneumophila induces human beta defensin-3 in pulmonary cells.

Respir Res. 2010 Jul 8;11:93.

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Seifert U, Bialy LP, Ebstein F, Bech-Otschir D, Voigt A, Schröter F, Prozorovski T, Lange N, Steffen J, Rieger M, Kuckelkorn U, Aktas O, Kloetzel PM, Krüger E

Immunoproteasomes preserve protein homeostasis upon interferon-induced oxidative stress

Cell 142, 613-622 (2010)

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Zahlten J, Steinicke R, Opitz B, Eitel J, N´guessan PD, Vinzing M, Witzenrath M, Schmeck B, Hammerschmidt S, Suttorp N, Hippenstiel S.

TLR2- and nucleotide-binding oligomerization domain 2-dependent Krüppel-like factor 2 expression downregulates NF-kappa B-related gene expression.

J Immunol. 2010 Jul 1;185(1):597-604. Epub 2010 Jun 4

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Bachem A, Güttler S, Hartung E, Ebstein F, Schäfer M, Tannert A, Salama A, Mavassaghi K, Opitz C, Mages HW, Henn V, Kloetzel PM, Gurka S, Kroczek R

Superior antigen cross-presentation and XCR1 expression define human CD11c+CD141+ cells as homologues of murine CD8+ cells

J Exp Med 207, 1273-81 (2010)

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Scharf S, Hippenstiel S, Flieger A, Suttorp N, N´Guessan PD.

Induction of human ß-defensin-2 in pulmonary epithelial cells by Legionella pneumophila: involvement of TLR2 and TLR5, p38 MAPK, JNK, NF-?B, and AP-1.

Am J Physiol Lung Cell Mol Physiol. 2010 May;298(5):L687-95. Epub 2010 Feb 12.

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Gutbier B, Kube SM, Reppe K, Santel A, Lange C, Kaufmann J, Suttorp N, Witzenrath M.

RNAi-mediated suppression of constitutive pulmonary gene expression by small interfering RNA in mice.

Pulm Pharmacol Ther. 2010 Aug;23(4):334-44. Epub 2010 Apr 1.

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Buss C, Opitz B, Hocke AC, Lippmann J, van Laak V, Hippenstiel S, Krüll M, Suttorp N, Eitel J.

Essential role of mitochondrial antiviral signaling, IFN regulatory factor (IRF)3, and IRF7 in Chlamydophila pneumoniae-mediated IFN-beta response and control of bacterial replication in human endothelial cells.

J Immunol. 2010 Mar 15;184(6):3072-8. Epub 2010 Feb 12.

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Meixenberger K, Pache F, Eitel J, Schmeck B, Hippenstiel S, Slevogt H, N´Guessan P, Witzenrath M, Netea MG, Chakraborty T, Suttorp N, Opitz B.

Listeria monocytogenes-infected human peripheral blood mononuclear cells produce IL-1beta,depending on listeriolysin O and NLRP3.

J Immunol. 2010 Jan 15;184(2):922-30. Epub 2009 Dec 11.

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