Transregio SFB-TR 84 “Innate Immunity of the Lung: Mechanisms of Pathogen Attack and Host Defence in Pneumonia“

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Publications

Hegemann N, Sang P, Kim JH, Koçana C, Momin N, Klages J, Kucherenko MM, Knosalla C, O'Brien B, Simmons S, Nahrendorf M, Kuebler WM, Grune J.

Ultrasonographic assessment of pulmonary and Central venous congestion in experimental heart failure

Am J Physiol Heart Circ Physiol. 2024 Feb 1;326(2):H433-H440. https://pubmed.ncbi.nlm.nih.gov/38099848/ 

Herbst CJ, Lopez-Rodriguez E, Gluhovic V, Schulz S, Brandt R, Timm S, Abledu J, Falivene J, Pennitz P, Kirsten H, Nouailles G, Witzenrath M, Ochs M, Kuebler WM.

Characterization of Commercially Available Human Primary Alveolar Epithelial Cells

Am J Respir Cell Mol Biol. Published online January 11, 2024. https://pubmed.ncbi.nlm.nih.gov/38207121/ 

Jung AL, Han M, Griss K, Bertrams W, Nell C, Greulich T, Klemmer A, Pott H, Heider D, Vogelmeier CF, Hippenstiel S, Suttorp N, Schmeck B.

Novel protein biomarkers for pneumonia and acute exacerbations in COPD: a pilot study.

Front Med (Lausanne). 2023 Jun 5;10:1180746. doi: 10.3389/fmed.2023.1180746. eCollection 2023. https://pubmed.ncbi.nlm.nih.gov/37342494/

Pappe E, Hammerich R, Saccomanno J, Sgarbossa T, Pohrt A, Schmidt B, Grah C, Eisenmann S, Holland A, Eggeling S, Stanzel F, Witzenrath M, Hübner RH.

Impact of COVID-19 on Hospital Admissions, Health Status, and Behavioral Changes of Patients with COPD.

Chronic Obstr Pulm Dis. 2023 May 3. doi: 10.15326/jcopdf.2022.0383. https://pubmed.ncbi.nlm.nih.gov/37140947/

Felten M, Dame C, Lachmann G, Spies C, Rubarth K, Balzer F, Kramer A, Witzenrath M.

Circadian rhythm disruption in critically ill patients.

Acta Physiol (Oxf). 2023 May;238(1):e13962. doi: 10.1111/apha.13962. https://pubmed.ncbi.nlm.nih.gov/36916859/

Asmus E, Karle W, Brack MC, Wittig C, Behrens F, Reinshagen L, Pfeiffer M, Schulz S, Mandzimba-Maloko B, Erfinanda L, Perret PL, Michalick L, Smeele PJ, Lim EHT, van den Brom CE, Vonk ABA, Kaiser T, Suttorp N, Hippenstiel S, Sander LE, Kurth F, Rauch U, Landmesser U, Haghikia A, Preissner R, Bogaard HJ, Witzenrath M, Kuebler WM, Szulcek R, Simmons S.

Cystic fibrosis transmembrane conductance regulator modulators attenuate platelet activation and aggregation in blood of healthy donors and COVID-19 patients.

Eur Respir J. 2023 Mar 23;61(3):2202009. doi: 10.1183/13993003.02009-2022. Print 2023 Mar.PMID: 36958745 https://pubmed.ncbi.nlm.nih.gov/36958745/

Goekeri C, Pennitz P, Groenewald W, Behrendt U, Kirsten H, Zobel CM, Berger S, Heinz GA, Mashreghi MF, Wienhold SM, Dietert K, Dorhoi A, Gruber AD, Scholz M, Rohde G, Suttorp N, Capnetz Study Group, Witzenrath M, Nouailles G.

MicroRNA-223 Dampens Pulmonary Inflammation during Pneumococcal Pneumonia.

Cells. 2023 Mar 21;12(6):959. doi: 10.3390/cells12060959.PMID: 36980300 https://pubmed.ncbi.nlm.nih.gov/36980300/

Weissfuss C, Wienhold SM, Bürkle M, Gaborieau B, Bushe J, Behrendt U, Bischoff R, Korf IHE, Wienecke S, Dannheim A, Ziehr H, Rohde C, Gruber AD, Ricard JD, Debarbieux L, Witzenrath M, Nouailles G.

Repetitive Exposure to Bacteriophage Cocktails against Pseudomonas aeruginosa or Escherichia coli Provokes Marginal Humoral Immunity in Naïve Mice

Viruses. 2023 Jan 29;15(2):387. doi: 10.3390/v15020387. https://pubmed.ncbi.nlm.nih.gov/36851601/

Pennitz P, Goekeri C, Trimpert J, Wyler E, Ebenig A, Weissfuss C, Mühlebach MD, Witzenrath M, Nouailles G.

Protocol to dissociate healthy and infected murine- and hamster-derived lung tissue for single-cell transcriptome analysis.

STAR Protoc. 2022 Dec 20;4(1):101957. doi: 10.1016/j.xpro.2022.101957. https://pubmed.ncbi.nlm.nih.gov/36542521/

Erfinanda L, Zou L, Gutbier B, Kneller L, Weidenfeld S, Michalick L, Lei D, Reppe K, Teixeira Alves LG, Schneider B, Zhang Q, Li C, Fatykhova D, Schneider P, Liedtke W, Sohara E, Mitchell TJ, Gruber AD, Hocke A, Hippenstiel S, Suttorp N, Olschewski A, Mall MA, Witzenrath M, Kuebler WM

Loss of endothelial CFTR drives barrier failure and edema formation in lung infection and can be targeted by CFTR potentiation

Sci Transl Med. 2022 Dec 7;14(674):eabg8577.
doi: 10.1126/scitranslmed.abg8577. https://pubmed.ncbi.nlm.nih.gov/36475904/

Bertrams W, Hönzke K, Obermayer B, Tönnies M, Bauer TT, Schneider P, Neudecker J, Rückert JC, Stiewe T, Nist A, Eggeling S, Suttorp N, Wolff T, Hippenstiel S, Schmeck B, Hocke AC

Transcriptomic comparison of primary human lung cells with lung tissue samples and the human A549 lung cell line highlights cell type specific responses during infections with influenza A virus

Sci Rep 12, 2022 Nov 29;12(1):20608.
doi 10.1038/s41598-022-24792-4. https://pubmed.ncbi.nlm.nih.gov/36446841/

Lingscheid T, Kinzig M, Krüger A, Müller N, Bölke G, Tober-Lau P, Münn F, Kriedemann H, Witzenrath M, Sander LE, Sörgel F, Kurth F.

Pharmacokinetics of Nirmatrelvir and Ritonavir in COVID-19 Patients with End-Stage Renal Disease on Intermittent Hemodialysis.

Antimicrob Agents Chemother. 2022 Nov 15;66(11):e0122922. doi: 10.1128/aac.01229-22. https://pubmed.ncbi.nlm.nih.gov/36286542/

Ni B, Chen S, Ryan KA, Maitland ML, Farrar JS, Witzenrath M, Gubier B, Serdjebi C, Bertotti K, Wang R, Salloum FN, Marino L, Mitchell BD, Celi FS.

Selective adipocyte loss of Angiopoietin-2 prompts female-specific obesity and metabolic syndrome.

Mol Metab. 2022 Nov;65:101588. doi: 10.1016/j.molmet.2022.101588. https://pubmed.ncbi.nlm.nih.gov/36055577/

Lask A, Gutbier B, Kershaw O, Nouailles G, Gruber AD, Müller-Redetzky HC, Chackowicz S, Hamilton DA, Van Slyke P, Witzenrath M.

Adjunctive therapy with the Tie2 agonist Vasculotide reduces pulmonary permeability in Streptococcus pneumoniae infected and mechanically ventilated mice

Sci Rep. 2022 Sep 15;12(1):15531. doi: 10.1038/s41598-022-19560-3 https://pubmed.ncbi.nlm.nih.gov/36109537/

Steinbeis F, Knape P, Mittermaier M, Helbig ET, Tober-Lau P, Thibeault C, Lippert LJ, Xiang W, Müller-Plathe M, Steinbrecher S, Meyer HJ, Ring RM, Ruwwe-Glösenkamp C, Alius F, Li Y, Müller-Redetzky H, Uhrig A, Lingscheid T, Grund D, Temmesfeld-Wollbrück B, Suttorp N, Sander LE, Kurth F, Witzenrath M, Zoller T.

Functional limitations 12 months after SARS-CoV-2 infection correlate with initial disease severity: An observational study of cardiopulmonary exercise capacity testing in COVID-19 convalescents.

Respir Med. 2022 Aug 28;202:106968. doi: 10.1016/j.rmed.2022.106968. https://pubmed.ncbi.nlm.nih.gov/36081267/

Pennitz P, Kirsten H, Friedrich VD, Wyler E, Goekeri C, Obermayer B, Heinz GA, Mashreghi MF, Büttner M, Trimpert J, Landthaler M, Suttorp N, Hocke AC, Hippenstiel S, Tönnies M, Scholz M, Kuebler WM, Witzenrath M, Hoenzke K, Nouailles G.

A pulmonologist's guide to perform and analyse cross-species single lung cell transcriptomics

Eur Respir Rev. 2022 Jul 27;31(165):220056. doi: 10.1183/16000617.0056-2022. https://pubmed.ncbi.nlm.nih.gov/35896273/

Hollenhorst MI, Nandigama R, Evers SB, Gamayun I, Abdel Wadood N, Salah A, Pieper M, Wyatt A, Stukalov A, Gebhardt A, Nadolni W, Burow W, Herr C, Beisswenger C, Kusumakshi S, Ectors F, Kichko TI, Hübner L, Reeh P, Munder A, Wienhold SM, Witzenrath M, Bals R, Flockerzi V, Gudermann T, Bischoff M, Lipp P, Zierler S, Chubanov V, Pichlmair A, König P, Boehm U, Krasteva-Christ G.

Bitter taste signaling in tracheal epithelial brush cells elicits innate immune responses to bacterial infection.

J Clin Invest. 2022; 132(13):e150951. https://pubmed.ncbi.nlm.nih.gov/35503420/

Tabeling C, González Calera CR, Lienau J, Höppner J, Tschernig T, Kershaw O, Gutbier B, Naujoks J, Herbert J, Opitz B, Gruber AD, Hocher B, Suttorp N, Heidecke H, Burmester GR, Riemekasten G, Siegert E, Kuebler WM, Witzenrath M.

Endothelin B Receptor Immunodynamics in Pulmonary Arterial Hypertension.

Front Immunol. 2022 Jun 9;13:895501. https://pubmed.ncbi.nlm.nih.gov/35757687/

Dannebaum R, Suwalski P, Asgharian H, Du Zhipei G, Lin H, Weiner J, Holtgrewe M, Thibeault C, Müller M, Wang X, Karadeniz Z, Saccomanno J, Doehn JM, Hübner RH, Hinzmann B, Blüher A, Siemann S, Telman D, Suttorp N, Witzenrath M, Hippenstiel S, Skurk C, Poller W, Sander LE, Beule D, Kurth F, Guettouche T, Landmesser U, Berka J, Luong K; Pa-COVID Study Group, Rubelt F, Heidecker B.

Highly multiplexed immune repertoire sequencing links multiple lymphocyte classes with severity of response to COVID-19.

EClinicalMedicine. 2022 Jun;48:101438. https://pubmed.ncbi.nlm.nih.gov/35600330/

Dannebaum R, Suwalski P, Asgharian H, Du Zhipei G, Lin H, Weiner J, Holtgrewe M, Thibeault C, Müller M, Wang X, Karadeniz Z, Saccomanno J, Doehn JM, Hübner RH, Hinzmann B, Blüher A, Siemann S, Telman D, Suttorp N, Witzenrath M, Hippenstiel S, Skurk C, Poller W, Sander LE, Beule D, Kurth F, Guettouche T, Landmesser U, Berka J, Luong K; Pa-COVID Study Group; Rubelt F, Heidecker B.

Highly multiplexed immune repertoire sequencing links multiple lymphocyte classes with severity of response to COVID-19

ClinicalMedicine. 2022 Jun;48:101438.  https://pubmed.ncbi.nlm.nih.gov/35600330/ 

Wyler E, Adler JM, Eschke K, Teixeira Alves G, Peidli S, Pott F, Kazmierski J, Michalick L, Kershaw O, Bushe J, Andreotti S, Pennitz P, Abdelgawad A, Postmus D, Goffinet C, Kreye J, Reincke SM, Prüss H, Blüthgen N, Gruber AD, Kuebler WM, Witzenrath M, Landthaler M, Nouailles G, Trimpert J.

Key benefits of dexamethasone and antibody treatment in COVID-19 hamster models revealed by single-cell transcriptomics

Mol Ther. 2022 May 4;30(5):1952-1965. doi: 10.1016/j.ymthe.2022.03.014. Epub 2022 Mar 24. https://pubmed.ncbi.nlm.nih.gov/35339689/

Lingscheid T, Lippert LJ, Hillus D, Kruis T, Thibeault C, Helbig ET, Tober-Lau P, Pfäfflin F, Müller-Redetzky H, Witzenrath M, Zoller T, Uhrig A, Opitz B, Suttorp N, Kramer TS, Sander LE, Stegemann MS, Kurth F.

Characterization of antimicrobial use and co-infections among hospitalized patients with COVID-19: a prospective observational cohort study.

Infection. 2022 Apr 14:1-12. https://pubmed.ncbi.nlm.nih.gov/35420370/

Kaplonek P, Yao L, Reppe K, Voß F, Kohler T, Ebner F, Schäfer A, Blohm U, Priegue P, Bräutigam M, Pereira CL, Parameswarappa SG, Emmadi M, Ménová P, Witzenrath M, Hammerschmidt S, Hartmann S, Sander LE, Seeberger PH.

A semisynthetic glycoconjugate provides expanded cross-serotype protection against Streptococcus pneumoniae

Vaccine. 2022 Feb 11;40(7):1038-1046.  doi: 10.1016/j.vaccine.2021.12.068.  Epub 2022 Jan 13. pubmed.ncbi.nlm.nih.gov/35033388/

Conrad C, Yildiz D, Cleary SJ, Margraf A, Cook L, Schlomann U, Panaretou B, Bowser JL, Karmouty-Quintana H, Li J, Berg NK, Martin SC, Aljohmani A, Moussavi-Harami SF, Wang KM, Tian JJ, Magnen M, Valet C, Qiu L, Singer JP, Eltzschig HK; CAPSys Study Group, Bertrams W, Herold S, Suttorp N, Schmeck B, Ball ZT, Zarbock A, Looney MR, Bartsch JW.

ADAM8 signaling drives neutrophil migration and ARDS severity

JCI Insight. 2022 Feb 8;7(3):e149870. doi: 10.1172/jci.insight.149870.  https://pubmed.ncbi.nlm.nih.gov/35132956/

Bahrs C, Kesselmeier M, Kolditz M, Ewig S, Rohde G, Barten-Neiner G, Rupp J, Witzenrath M, Welte T, Pletz MW; CAPNETZ Study Group.

A longitudinal analysis of pneumococcal vaccine serotypes in pneumonia patients in Germany

Eur Respir J. 2022 Feb 3;59(2):2102432. doi: 10.1183/13993003.02432-2021. Print 2022 Feb. https://pubmed.ncbi.nlm.nih.gov/34824055/

Demichev V, Tober-Lau P, Nazarenko T, Lemke O, Kaur Aulakh S, Whitwell HJ, Röhl A, Freiwald A, Mittermaier M, Szyrwiel L, Ludwig D, Correia-Melo C, Lippert LJ, Helbig ET, Stubbemann P, Olk N, Thibeault C, Grüning NM, Blyuss O, Vernardis S, White M, Messner CB, Joannidis M, Sonnweber T, Klein SJ, Pizzini A, Wohlfarter Y, Sahanic S, Hilbe R, Schaefer B, Wagner S, Machleidt F, Garcia C, Ruwwe-Glösenkamp C, Lingscheid T, Bosquillon de Jarcy L, Stegemann MS, Pfeiffer M, Jürgens L, Denker S, Zickler D, Spies C, Edel A, Müller NB, Enghard P, Zelezniak A, Bellmann-Weiler R, Weiss G, Campbell A, Hayward C, Porteous DJ, Marioni RE, Uhrig A, Zoller H, Löffler-Ragg J, Keller MA, Tancevski I, Timms JF, Zaikin A, Hippenstiel S, Ramharter M, Müller-Redetzky H, Witzenrath M, Suttorp N, Lilley K, Mülleder M, Sander LE; PA-COVID-19 Study group; Kurth F, Ralser M.

A proteomic survival predictor for COVID-19 patients in intensive care.

PLOS Digit Health. 2022 Jan 18;1(1):e0000007. doi: 10.1371/journal.pdig.0000007. https://pubmed.ncbi.nlm.nih.gov/36812516/

Kühnapfel A, Horn K, Klotz U, Kiehntopf M, Rosolowski M, Loeffler M, Ahnert P, Suttorp N, Witzenrath M, Scholz M.

Genetic Regulation of Cytokine Response in Patients with Acute Community-Acquired Pneumonia.

Genes (Basel). 2022 Jan 6;13(1):111. https://pubmed.ncbi.nlm.nih.gov/35052452/

Wienhold SM, Brack MC, Nouailles G, Krishnamoorthy G, Korf IHE, Seitz C, Wienecke S, Dietert K, Gurtner C, Kershaw O, Gruber AD, Ross A, Ziehr H, Rohde M, Neudecker J, Lienau J, Suttorp N, Hippenstiel S, Hocke AC, Rohde C, Witzenrath M.

Preclinical Assessment of Bacteriophage Therapy against Experimental Acinetobacter baumannii Lung Infection.

Viruses. 2021 Dec 24;14(1):33. https://pubmed.ncbi.nlm.nih.gov/35062236/

Letsiou E, Teixeira Alves LG, Felten M, Mitchell TJ, Müller-Redetzky HC, Dudek SM, Witzenrath M.

Neutrophil-Derived Extracellular Vesicles Activate Platelets after Pneumolysin Exposure.

Cells. 2021;10(12):3581. https://pubmed.ncbi.nlm.nih.gov/34944089/

Steinbeis F, Thibeault C, Doellinger F, Ring RM, Mittermaier M, Ruwwe-Glösenkamp C, Alius F, Knape P, Meyer HJ, Lippert LJ, Helbig ET, Grund D, Temmesfeld-Wollbrück B, Suttorp N, Sander LE, Kurth F, Penzkofer T, Witzenrath M, Zoller T.

Severity of respiratory failure and computed chest tomography in acute COVID-19 correlates with pulmonary function and respiratory symptoms after infection with SARS-CoV-2: An observational longitudinal study over 12 months.

Respir Med. 2021 Dec 1;191:106709. doi: 10.1016/j.rmed.2021.106709. Epub ahead of print. PMID: 34871947; PMCID: PMC8632363. pubmed.ncbi.nlm.nih.gov/34871947/

Wendisch D, Dietrich O, Mari T, von Stillfried S, Ibarra IL, Mittermaier M, Mache C, Chua RL, Knoll R, Timm S, Brumhard S, Krammer T, Zauber H, Hiller AL, Pascual-Reguant A, Mothes R, Bülow RD, Schulze J, Leipold AM, Djudjaj S, Erhard F, Geffers R, Pott F, Kazmierski J, Radke J, Pergantis P, Baßler K, Conrad C, Aschenbrenner AC, Sawitzki B, Landthaler M, Wyler E, Horst D; Deutsche COVID-19 OMICS Initiative (DeCOI), Hippenstiel S, Hocke A, Heppner FL, Uhrig A, Garcia C, Machleidt F, Herold S, Elezkurtaj S, Thibeault C, Witzenrath M, Cochain C, Suttorp N, Drosten C, Goffinet C, Kurth F, Schultze JL, Radbruch H, Ochs M, Eils R, Müller-Redetzky H, Hauser AE, Luecken MD, Theis FJ, Conrad C, Wolff T, Boor P, Selbach M, Saliba AE, Sander LE.

SARS-CoV-2 infection triggers profibrotic macrophage responses and lung fibrosis.

Cell. 2021 Nov 27:S0092-8674(21)01383-0. doi: 10.1016/j.cell.2021.11.033. Epub ahead of print. PMID: 34914922. pubmed.ncbi.nlm.nih.gov/34914922/

Weiner J, Suwalski P, Holtgrewe M, Rakitko A, Thibeault C, Müller M, Patriki D, Quedenau C, Krüger U, Ilinsky V, Popov I, Balnis J, Jaitovich A, Helbig ET, Lippert LJ, Stubbemann P, Real LM, Macías J, Pineda JA, Fernandez-Fuertes M, Wang X, Karadeniz Z, Saccomanno J, Doehn JM, Hübner RH, Hinzmann B, Salvo M, Blueher A, Siemann S, Jurisic S, Beer JH, Rutishauser J, Wiggli B, Schmid H, Danninger K, Binder R, Corman VM, Mühlemann B, Arjun Arkal R, Fragiadakis GK, Mick E, Comet C, Calfee CS, Erle DJ, Hendrickson CM, Kangelaris KN, Krummel MF, Woodruff PG, Langelier CR, Venkataramani U, García F, Zyla J, Drosten C, Alice B, Jones TC, Suttorp N, Witzenrath M, Hippenstiel S, Zemojtel T, Skurk C, Poller W, Borodina T, Pa-Covid SG, Ripke S, Sander LE, Beule D, Landmesser U, Guettouche T, Kurth F, Heidecker B.

Increased risk of severe clinical course of COVID-19 in carriers of HLA-C*04:01

EClinicalMedicine. 2021 Oct;40:101099. doi: 10.1016/j.eclinm.2021.101099. Epub 2021 Sep 2. PMID: 34490415; PMCID: PMC8410317. pubmed.ncbi.nlm.nih.gov/34490415/

Hillus D, Schwarz T, Tober-Lau P, Vanshylla K, Hastor H, Thibeault C, Jentzsch S, Helbig ET, Lippert LJ, Tscheak P, Schmidt ML, Riege J, Solarek A, von Kalle C, Dang-Heine C, Gruell H, Kopankiewicz P, Suttorp N, Drosten C, Bias H, Seybold J; EICOV/COVIM Study Group, Klein F, Kurth F, Corman VM, Sander LE.

Safety, reactogenicity, and immunogenicity of homologous and heterologous prime-boost immunisation with ChAdOx1 nCoV-19 and BNT162b2: a prospective cohort study.

Lancet Respir Med. 2021 Aug 12:S2213-2600(21)00357-X. doi: 10.1016/S2213-2600(21)00357-X. Epub ahead of print. PMID: 34391547; PMCID: PMC8360702. pubmed.ncbi.nlm.nih.gov/34391547/

Demichev V, Tober-Lau P, Lemke O, Nazarenko T, Thibeault C, Whitwell H, Röhl A, Freiwald A, Szyrwiel L, Ludwig D, Correia-Melo C, Aulakh SK, Helbig ET, Stubbemann P, Lippert LJ, Grüning NM, Blyuss O, Vernardis S, White M, Messner CB, Joannidis M, Sonnweber T, Klein SJ, Pizzini A, Wohlfarter Y, Sahanic S, Hilbe R, Schaefer B, Wagner S, Mittermaier M, Machleidt F, Garcia C, Ruwwe-Glösenkamp C, Lingscheid T, Bosquillon de Jarcy L, Stegemann MS, Pfeiffer M, Jürgens L, Denker S, Zickler D, Enghard P, Zelezniak A, Campbell A, Hayward C, Porteous DJ, Marioni RE, Uhrig A, Müller-Redetzky H, Zoller H, Löffler-Ragg J, Keller MA, Tancevski I, Timms JF, Zaikin A, Hippenstiel S, Ramharter M, Witzenrath M, Suttorp N, Lilley K, Mülleder M, Sander LE; PA-COVID-19 Study group, Ralser M, Kurth F.

A time-resolved proteomic and prognostic map of COVID-19

Cell Syst. 2021 Jun 14:S2405-4712(21)00160-5. doi: 10.1016/j.cels.2021.05.005. Epub ahead of print. PMID: 34139154; PMCID: PMC8201874. pubmed.ncbi.nlm.nih.gov/34139154/

Witzenrath M, Kuebler WM.

The CypA-netics of Ventilator-Induced Lung Injury

Am J Respir Crit Care Med. 2021 May 25. doi: 10.1164/rccm.202104-0919ED. Epub ahead of print. PMID: 34033522. pubmed.ncbi.nlm.nih.gov/34033522/

Letsiou E, Teixeira Alves LG, Fatykhova D, Felten M, Mitchell TJ, Müller-Redetzky HC, Hocke AC, Witzenrath M.

Microvesicles released from pneumolysin-stimulated lung epithelial cells carry mitochondrial cargo and suppress neutrophil oxidative burst

Sci Rep. 2021 May 5;11(1):9529. doi: 10.1038/s41598-021-88897-y. PMID: 33953279; PMCID: PMC8100145. pubmed.ncbi.nlm.nih.gov/33953279/

Hadzibegovic S, Lena A, Churchill TW, Ho JE, Potthoff S, Denecke C, Rösnick L, Heim KM, Kleinschmidt M, Sander LE, Witzenrath M, Suttorp N, Krannich A, Porthun J, Friede T, Butler J, Wilkenshoff U, Pieske B, Landmesser U, Anker SD, Lewis GD, Tschöpe C, Anker MS.

Heart failure with preserved ejection fraction according to the HFA-PEFF score in COVID-19 patients: clinical correlates and echocardiographic findings

Eur J Heart Fail. 2021 May 1:10.1002/ejhf.2210. doi: 10.1002/ejhf.2210. Epub ahead of print. PMID: 33932255; PMCID: PMC8239668. pubmed.ncbi.nlm.nih.gov/33932255/

Messner CB, Demichev V, Bloomfield N, Yu JSL, White M, Kreidl M, Egger AS, Freiwald A, Ivosev G, Wasim F, Zelezniak A, Jürgens L, Suttorp N, Sander LE, Kurth F, Lilley KS, Mülleder M, Tate S, Ralser M.

Ultra-fast proteomics with Scanning SWATH.

Nat Biotechnol. 2021 Mar 25. doi: 10.1038/s41587-021-00860-4. Online ahead of print. PMID: 33767396. pubmed.ncbi.nlm.nih.gov/33767396/

Doehn JM, Tabeling C, Biesen R, Saccomanno J, Madlung E, Pappe E, Gabriel F, Kurth F, Meisel C, Corman VM, Hanitsch LG, Treskatsch S, Heim K, Stegemann MS, Ruwwe-Glösenkamp C, Müller-Redetzky HC, Uhrig A, Somasundaram R, Spies C, von Bernuth H, Hofmann J, Drosten C, Suttorp N, Witzenrath M, Sander LE, Hübner RH.

CD169/SIGLEC1 is expressed on circulating monocytes in COVID-19 and expression levels are associated with disease severity

Infection. 2021 Apr 6:1–6. doi: 10.1007/s15010-021-01606-9. Epub ahead of print. PMID: 33825125; PMCID: PMC8023546. pubmed.ncbi.nlm.nih.gov/33825125/

Bertrams W, Griss K, Han M, Seidel K, Hippenstiel S, Suttorp N, Finkernagel F, Wilhelm J, Vogelmeier CF, Schmeck B.

Transcriptional analysis identifies potential biomarkers and molecular regulators in acute malaria infection

Life Sci. 2021 Apr 1;270:119158. doi: 10.1016/j.lfs.2021.119158. Epub 2021 Feb 2. PMID: 33545200. pubmed.ncbi.nlm.nih.gov/33545200/

Tabeling C, Wienhold SM, Birnhuber A, Brack MC, Nouailles G, Kershaw O, Firsching TC, Gruber AD, Lienau J, Marsh LM, Olschewski A, Kwapiszewska G, Witzenrath M.

Pulmonary fibrosis in Fra-2 transgenic mice is associated with decreased numbers of alveolar macrophages and increased susceptibility to pneumococcal pneumonia

Am J Physiol Lung Cell Mol Physiol. 2021 Mar 3. doi: 10.1152/ajplung.00505.2020. Epub ahead of print. PMID: 33655757. pubmed.ncbi.nlm.nih.gov/33655757/

Thibeault C, Suttorp N, Opitz B

The microbiota in pneumonia: from protection to predisposition.

Sci Transl Med. 2021 Jan 13;13(576):eaba0501. doi: 10.1126/scitranslmed.aba0501. PMID: 33441423. pubmed.ncbi.nlm.nih.gov/33441423/

Vlaar APJ, de Bruin S, Busch M, Timmermans SAMEG, van Zeggeren IE, Koning R, Ter Horst L, Bulle EB, van Baarle FEHP, van de Poll MCG, Kemper EM, van der Horst ICC, Schultz MJ, Horn J, Paulus F, Bos LD, Wiersinga WJ, Witzenrath M, Rueckinger S, Pilz K, Brouwer MC, Guo RF, Heunks L, van Paassen P, Riedemann NC, van de Beek D.

Anti-C5a antibody IFX-1 (vilobelimab) treatment versus best supportive care for patients with severe COVID-19 (PANAMO): an exploratory, open-label, phase 2 randomised controlled trial

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