Transregio SFB-TR 84 “Innate Immunity of the Lung: Mechanisms of Pathogen Attack and Host Defence in Pneumonia“

A A A

Forgot password?

Publications

Robak OH, Heimesaat MM, Kruglov AA, Prepens S, Ninnemann J, Gutbier B, Reppe K, Hochrein H, Suter M, Kirschning CJ, Marathe V, Buer J, Hornef MW, Schnare M, Schneider P, Witzenrath M, Bereswill S, Steinhoff U, Suttorp N, Sander LE, Chaput C, Opitz B

Antibiotic treatment-induced secondary IgA deficiency enhances susceptibility to Pseudomonas aeruginosa pneumonia.

J Clin Invest. 2018 Jul 16. pii: 97065

www.jci.org/articles/view/97065

Erickson NA, Dietert K, Enders J, Glauben R, Nouailles G, Gruber AD, Mundhenk L

Soluble mucus component CLCA1 modulates expression of leukotactic cytokines and BPIFA1 in murine alveolar macrophages but not in bone marrow-derived macrophages.

Histochem Cell Biol. 2018 Apr 2. doi: 10.1007/s00418-018-1664-y

www.ncbi.nlm.nih.gov/pubmed/29610986

Schumann B, Reppe K, Kaplonek P, Wahlbrink A, Anish C, Witzenrath M, Pereira CL, Seeberger PH

Development of an Efficacious, Semisynthetic Glycoconjugate Vaccine Candidate against Streptococcus pneumoniae Serotype 1.

ACS Cent Sci. 2018 4,357-361.

www.ncbi.nlm.nih.gov/pubmed/29632881

Gutbier B, Neuhauß AK, Reppe K, Ehrler C, Santel A, Kaufmann J, Scholz M, Weissmann N, Morawietz L, Mitchell TJ, Aliberti S, Hippenstiel S, Suttorp N, Witzenrath M; CAPNETZ and PROGRESS study groups

Prognostic and Pathogenic Role of Angiopoietin-1 and -2 in Pneumonia.

Am J Respir Crit Care Med. 2018 Feb 15

www.ncbi.nlm.nih.gov/pubmed/29447449

Nerlich A, Mieth M, Letsiou E, Fatykhova D, Zscheppang K, Matsushima AI, Meyer TF, Paasch L, Mitchell T, Tönnies M, Bauer TT, Schneider P, Neudecker J, Rückert J, Eggeling S, Schimek M, Witzenrath M, Suttorp N, Hippenstiel S, Hocke AC

Pneumolysin induced mitochondrial dysfunction leads to release of mitochondrial DNA.

Scientific Reports (2018) 8:182

www.nature.com/articles/s41598-017-18468-7

Ruiz-Moreno JS, Hamann L, Shah JA, Verbon A, Mockenhaupt FP, Puzianowska-Kuznicka M, Naujoks J, Sander LE, Witzenrath M, Cambier JC, Suttorp N, Schumann RR, Jin L, Hawn TR,  Opitz B,  CAPNETZ Study Group

The common HAQ STING variant impairs cGAS-dependent antibacterial responses and is associated with susceptibility to Legionnaires' disease in humans.

PLoS Pathog. 2018 Jan 3;14(1)

journals.plos.org/plospathogens/article

Gutbier B, Schönrock SM, Ehrler C, Haberberger R, Dietert K, Gruber AD, Kummer W, Michalik L, Kübler WM, Hocke AC, Szymanski K, Letsiou E, Lüth A, Schumacher F, Kleuser B, Mitchell TJ, Bertrams W, Schmeck B, Treue D, Klauschen F, Bauer TT, Tönnies M, Weissmann N, Hippenstiel S, Suttorp N, Witzenrath M, CAPNETZ Study Group

Sphingosine kinase 1 regulates inflammation and contributes to acute lung injury in pneumococcal pneumonia via the S1P receptor 2.

Crit Care Med. 2018 Jan 2.

www.ncbi.nlm.nih.gov/pubmed/29298188

Ruiz-Moreno JS, Hamann L, Jin L, Sander LE, Puzianowska-Kuznickad M, Cambier JC, Witzenrath M, Schumann RR, Suttorp N, Opitz B, CAPNETZ Study Group

The cGAS/STING pathway detects Streptococcus pneumoniae but is dispensable for anti-pneumococcal defense in mice and humans.

Infect Immun. 2017 Dec 20. pii: IAI.00849-17

iai.asm.org/content/early/2017/12/13/IAI.00849-17.abstract

Jensen AV, Faurholt-Jepsen D, Egelund GB, Andersen SB, Petersen PT, Benfield T, Witzenrath M, Rohde G, Ravn P; German Community-Acquired Pneumonia Competence Network (CAPNETZ)

Undiagnosed Diabetes Mellitus in Community-Acquired Pneumonia: A Prospective Cohort Study.

Clin Infect Dis. 2017 Nov 29;65(12):2091-2098

academic.oup.com/cid/article/65/12/2091/4582709

Dietert K, Gutbier B, Wienhold SM, Reppe K, Jiang X, Yao L, Chaput C, Naujoks J, Brack M, Kupke A, Peteranderl C, Becker S, von Lachner C, Baal N, Slevogt H, Hocke AC, Witzenrath M, Opitz B, Herold S, Hackstein H, Sander LE, Suttorp N, Gruber AD

Spectrum of pathogen- and model-specific histopathologies in mouse models of acute pneumonia.

PLoS One. 2017 Nov 20;12(11):e0188251

www.ncbi.nlm.nih.gov/pubmed/29155867

Gutbier B, Jiang X, Dietert K, Ehrler C, Lienau J, Van Slyke P, Kim H, Van Hoang C, Maynes JT, Dumont DJ, Gruber AD, Weissmann N, Mitchell TJ, Suttorp N, Witzenrath M

Vasculotide reduces pulmonary hyperpermeability in experimental pneumococcal pneumonia.

Critical Care 2017 Nov 13;21(1):274

www.ncbi.nlm.nih.gov/pubmed/29132435

Emmadi M, Khan N, Lykke L, Reppe K, Parameswarappa S, Lisboa MP, Wienhold SM, Witzenrath M, Pereira CL, Seeberger PH

A Streptococcus pneumoniae type 2 oligosaccharide glycoconjugate elicits opsonic antibodies and is protective in an animal model of invasive pneumococcal disease.

J Am Chem Soc 2017 Oct 4 [Epub ahead of print]

www.ncbi.nlm.nih.gov/pubmed/28945368

Lisboa MP, Khan N, Martin C, Xu FF, Reppe K, Geissner A, Govindan S, Witzenrath M, Pereira CL, Seeberger PH

Semisynthetic glycoconjugate vaccine candidate against Streptococcus pneumoniae serotype 5.

Proc Natl Acad Sci USA 2017 Oct 2 [Epub ahead of print]

www.ncbi.nlm.nih.gov/pubmed/28973947

Seeberger PH, Pereira CL, Khan N, Xiao G, Diago-Navarro E, Reppe K, Opitz B, Fries BC, Witzenrath M

A semi-synthetic glycoconjugate vaccine candidate for carbapenem-resistant Klebsiella pneumoniae.

Angew Chem Int Ed Engl. 2017 Aug 16

www.pubmed.de/gateway/nlm-pubmed/28815890

Wygrecka M, Kosanovic D, Wujak L, Reppe K, Henneke I, Frey H, Didiasova M, Kwapiszewska G, Marsh LM, Baal N, Hackstein H, Zakrzewicz D, Müller-Redetzky HC, de Maat S, Maas C, Nolte MW, Panousis C, Schermuly RT, Seeger W, Witzenrath M, Schaefer L, Markart P

Antihistone Properties of C1 Esterase Inhibitor Protect against Lung Injury.

Am J Respir Crit Care Med. 2017 Jul 15;196(2):186-199

www.ncbi.nlm.nih.gov/pubmed/28005404

Tabeling C, Herbert J, Hocke AC, Lamb DJ, Wollin SL, Erb KJ, Boiarina E, Movassagh H, Scheffel J, Doehn JM, Hippenstiel S, Maurer M, Gounni AS, Kuebler WM, Suttorp N, Witzenrath M

Spleen tyrosine kinase inhibition blocks airway constriction and protects from Th2-induced airway inflammation and remodeling.

Allergy. 2017 Jul;72(7):1061-1072

www.ncbi.nlm.nih.gov/pubmed/ 27906453

Schumann B, Hahm HS, Parameswarappa SG, Reppe K, Wahlbrink A, Govindan S, Kaplonek P, Pirofski LA, Witzenrath M, Anish C, Pereira CL, Seeberger PH

A semisynthetic Streptococcus pneumoniae serotype 8 glycoconjugate vaccine.

Sci Transl Med. 2017 Mar 8;9(380)

www.ncbi.nlm.nih.gov/pubmed/28275152

Parameswarappa SG, Reppe K, Geissner A, Ménová P, Govindan S, Calow AD, Wahlbrink A, Weishaupt MW, Monnanda BP, Bell RL, Pirofski LA, Suttorp N, Sander LE, Witzenrath M, Pereira CL, Anish C, Seeberger PH

A Semi-synthetic Oligosaccharide Conjugate Vaccine Candidate Confers Protection against Streptococcus pneumoniae Serotype 3 Infection.

Cell Chem Biol. 2016 Nov 2. pii: S2451-9456(16)30356-7

www.ncbi.nlm.nih.gov/pubmed/27818299

Schaefer MB, Schaefer CA, Schifferings S, Kuhlmann CR, Urban A, Benscheid U, Fischer T, Hecker M, Morty RE, Vadasz I, Herold S, Witzenrath M, Seeger W, Erdogan A, Mayer K

N-3 vs. n-6 fatty acids differentially influence calcium signalling and adhesion of inflammatory activated monocytes: impact of lipid rafts.

Inflamm Res. 2016 Nov;65(11):881-894

www.ncbi.nlm.nih.gov/pubmed/27384606

Kostadinova E, Chaput C, Gutbier B, Lippmann J, Sander LE, Mitchell TJ, Suttorp N, Witzenrath M, Opitz B

NLRP3 protects alveolar barrier integrity by an inflammasome-independent increase of epithelial cell adherence

Sci Rep. 2016 Aug 1;6:30943

www.ncbi.nlm.nih.gov/pubmed/27476670

Tabeling C, Noe E, Naujoks J, Doehn JM, Hippenstiel S, Opitz B, Suttorp N, Klopfleisch R, Witzenrath M

PKCα Deficiency in Mice Is Associated with Pulmonary Vascular Hyperresponsiveness to Thromboxane A2 and Increased Thromboxane Receptor Expression.

J Vasc Res. 2015;52(4):279-88

www.ncbi.nlm.nih.gov/pubmed/26890419

Naujoks J, Tabeling C, Dill BD, Hoffmann C, Brown AS, Kunze M, Kempa S, Peter A, Mollenkopf HJ, Dorhoi A, Kershaw O, Gruber AD, Sander LE, Witzenrath M, Herold S, Nerlich A, Hocke AC, van Driel I, Suttorp N, Bedoui S, Hilbi H, Trost M, Opitz B

IFNs Modify the Proteome of Legionella-Containing Vacuoles and Restrict Infection Via IRG1-Derived Itaconic Acid.

PLoS Pathog. 2016 Feb 1;12(2)

www.ncbi.nlm.nih.gov/pubmed/26829557

Müller-Redetzky H, Lienau J, Suttorp N, Witzenrath M

Therapeutic strategies in pneumonia: going beyond antibiotics.

Eur Respir Rev. 2015 Sep;24(137):516-24

www.ncbi.nlm.nih.gov/pubmed/26324814

Gutbier B, Fischer K, Doehn JM, von Lachner C, Herr C, Klaile E, Frischmann U, Singer BB, Riesbeck K, Zimmermann W, Suttorp N, Bachmann S, Bals R, Witzenrath M, Slevogt H

Moraxella catarrhalis induces an immune response in the murine lung that is independent of human CEACAM5 expression and long-term smoke exposure.

Am J Physiol Lung Cell Mol Physiol. 2015 Aug 1;309(3):L250-61

www.ncbi.nlm.nih.gov/pubmed/26047639

Müller-Redetzky HC, Wienhold SM, Berg J, Hocke AC, Hippenstiel S, Hellwig K, Gutbier B, Opitz B, Neudecker J, Rückert J, Gruber AC, Kershaw O, Mayer K,  Suttorp N, Witzenrath M

Moxifloxacin is not anti-inflammatory in experimental pneumococcal pneumonia.

J Antimicrob Chemother. 2015 Mar;70(3):830-40

www.ncbi.nlm.nih.gov/pubmed/25406299

Tabeling C, Yu H, Wang L, Ranke H, Goldenberg NM, Zabini D, Noe E, Krauszman A, Gutbier B, Yin J, Schaefer M, Arenz C, Hocke AC, Suttorp N, Proia RL, Witzenrath M, Kuebler WM

CFTR and sphingolipids mediate hypoxic pulmonary vasoconstriction.

Proc Natl Acad Sci U S A. 2015 Mar 31;112(13):E1614-23

www.ncbi.nlm.nih.gov/pubmed/25829545

Dietert K, Mundhenk L, Erickson NA, Reppe K, Hocke AC, Kummer W, Witzenrath M, Gruber AD

Murine CLCA5 is uniquely expressed in distinct niches of airway epithelial cells.

Histochem Cell Biol. 2015 Mar;143(3):277-87. doi: 10.1007/s00418-014-1279-x.

www.ncbi.nlm.nih.gov/pmc/articles/PMC4317516/

Müller-Redetzky HC, Felten M, Hellwig K, Wienhold SM, Naujoks J, Opitz B, Kershaw O, Gruber AD, Suttorp N, Witzenrath M

Increasing the inspiratory time and I:E ratio during mechanical ventilation aggravates ventilator-induced lung injury in mice.

Critical Care 2015, 19:23

www.ncbi.nlm.nih.gov/pubmed/25888164

Dames C, Akyüz L, Reppe K, Tabeling C, Dietert K, Kershaw O, Gruber AD, Meisel C, Meisel A, Witzenrath M, Engel O

Miniaturized bronchoscopy enables unilateral investigation, application, and sampling in mice.

Am J Respir Cell Mol Biol. 2014 Dec;51(6):730-7

www.ncbi.nlm.nih.gov/pubmed/24960575

Savai R, Al-Tamari HM, Sedding D, Kojonazarov B, Muecke C, Teske R, Capecchi MR, Weissmann N, Grimminger F, Seeger W, Schermuly RT, Pullamsetti SS

Pro-proliferative and inflammatory signaling converge on FoxO1 transcription factor in pulmonary hypertension.

Nat Med. 2014 Nov;20(11):1289-300

www.ncbi.nlm.nih.gov/pubmed/25344740

Noe E, Tabeling C, Doehn JM, Naujoks J, Opitz B, Hippenstiel S, Witzenrath M, Klopfleisch R

Juvenile megaesophagus in PKCα-deficient mice is associated with an increase in the segment of the distal esophagus lined by smooth muscle cells.

Ann Anat. 2014 Sep;196(5):365-71

www.ncbi.nlm.nih.gov/pubmed/24862691

Veith NT, Tschernig T, Gutbier B, Witzenrath M, Meier C, Menger M, Bischoff M

Surfactant protein A mediates pulmonary clearance of Staphylococcus aureus.

Respir Res. 2014 Aug 5;15:85

www.ncbi.nlm.nih.gov/pubmed/25091948

Heine G, Tabeling C, Hartmann B, González Calera CR, Kühl AA, Lindner J, Radbruch A, Witzenrath M, Worm M

25-hydroxvitamin D3 promotes the long-term effect of specific immunotherapy in a murine allergy model.

J Immunol. 2014 Aug 1;193(3)

www.ncbi.nlm.nih.gov/pubmed/24951815

Witzenrath M

Endothelial progenitor cells for acute respiratory distress syndrome treatment: support your local sheriff!

Am J Respir Crit Care Med. 2014 Jun 15;189(12):1452-5

www.ncbi.nlm.nih.gov/pubmed/24930525

Weissmann N, Peters DM, Klöpping C, Krüger K, Pilat C, Katta S, Seimetz M, Ghofrani HA, Schermuly RT, Witzenrath M, Seeger W, Grimminger F, Mooren FC

Structural and functional prevention of hypoxia-induced pulmonary hypertension by individualized exercise training in mice.

Am J Physiol Lung Cell Mol Physiol. 2014 Jun 1;306(11):L986-95

www.ncbi.nlm.nih.gov/pubmed/24705723

Tabeling C, Scheer H, Schönrock SM, Runge F, Gutbier B, Lienau J, Hamelmann E, Opitz B, Suttorp N, Mayer K, Behrens GM, Tschernig T, Witzenrath M

Nucleotide oligomerization domain 1 ligation suppressed murine allergen-specific T-cell proliferation and airway hyperresponsiveness.

Am J Respir Cell Mol Biol. 2014 May;50(5):903-11

www.ncbi.nlm.nih.gov/pubmed/24279792

Müller-Redetzky HC, Will D, Hellwig K, Kummer W, Tschernig T, Pfeil U, Paddenberg R, Menger MD, Kershaw O, Gruber AD, Weissmann N, Hippenstiel S, Suttorp N, Witzenrath M

Mechanical ventilation drives lung injury and sepsis in pneumococcal pneumonia: protection by Adrenomedullin

Crit Care. 2014 Apr 14;18(2):R73

www.ncbi.nlm.nih.gov/pubmed/24731244

Müller-Redetzky HC, Suttorp N, Witzenrath M

Dynamics of pulmonary endothelial barrier function in acute inflammation: mechanisms and therapeutic perspectives.

Cell Tissue Res. 2014 Mar;355(3):657-73

www.ncbi.nlm.nih.gov/pubmed/24599335

Kill A, Tabeling C, Undeutsch R, Kühl AA, Günther J, Radic M, Becker MO, Heidecke H, Worm M, Witzenrath M, Burmester GR, Dragun D, Riemekasten G

Autoantibodies to angiotensin and endothelin receptors in systemic sclerosis induce cellular and systemic events associated with disease pathogenesis.

Arthritis Res Ther. 2014 Jan 28;16(1):R29

www.ncbi.nlm.nih.gov/pubmed/24472528

Malczyk M, Veith C, Fuchs B, Hofmann K, Storch U, Schermuly RT, Witzenrath M, Ah

Classical Transient Receptor Potential Channel 1 in Hypoxia-induced Pulmonary Hypertension.

Am J Respir Crit Care Med. 2013 Dec 15;188(12):1451-9.

www.ncbi.nlm.nih.gov/pubmed/24251695

Tabeling C, Scheer H, Schönrock SM, Runge F, Gutbier B, Lienau J, Hamelmann E, Opitz B, Suttorp N, Mayer K, Behrens GM, Tschernig T, Witzenrath M.

NOD1 Ligation Suppressed Murine Allergen-Specific T Cell Proliferation and Airway Hyperresponsiveness.

Am J Respir Cell Mol Biol. 2013 Nov 26.

www.ncbi.nlm.nih.gov/pubmed/24279792

Schulz R, Murzabekova G, Egemnazarov B, Kraut S, Eisele HJ, Dumitrascu R, Heitmann J, Seimetz M, Witzenrath M, Ghofrani HA, Schermuly RT, Grimminger F, Seeger W, Weissmann N.

Arterial hypertension in a murine model of sleep apnea: role of NADPH oxidase 2.

J Hypertens. 2013 Nov 21.

www.ncbi.nlm.nih.gov/pubmed/24270180

Bayat B, Tjahjono Y, Sydykov A, Werth S, Hippenstiel S, Weissmann N, Sachs UJ, Santoso S.

Anti-Human Neutrophil Antigen-3a Induced Transfusion-Related Acute Lung Injury in Mice by Direct Disturbance of Lung Endothelial Cells.

Arterioscler Thromb Vasc Biol. 2013 Sep 12. [Epub ahead of print]

www.ncbi.nlm.nih.gov/pubmed/24008160

Bakr A, Pak O, Taye A, Hamada F, Hemeida R, Janssen W, Gierhardt M, Ghofrani HA, Seeger W, Grimminger F, Schermuly RT, Witzenrath M, Brandes RP, Huang N, Cooke JP, Weissmann N, Sommer N.

Effects of dimethylarginine dimethylaminohydrolase-1 overexpression on the response of the pulmonary vasculature to hypoxia

Am J Respir Cell Mol Biol. 2013 Sep;49(3):491-500

www.ncbi.nlm.nih.gov/pubmed/23642043

Zahlten J, Steinicke R, Bertrams W, Hocke AC, Scharf S, Schmeck B, Witzenrath M, Hammerschmidt S, Suttorp N, Hippenstiel S.

TLR9- and Src-dependent expression of Krueppel-like factor 4 controls interleukin-10 expression in pneumonia.

Eur Respir J. 2013 Feb;41(2):384-91. Epub 2012 May 31

www.ncbi.nlm.nih.gov/pubmed/22653776

Hecker M, Sommer N, Voigtmann H, Pak O, Mohr A, Wolf M, Vadász I, Herold S, Weissmann N, Morty R, Seeger W, Mayer K.

Impact of Short- and Medium-Chain Fatty Acids on Mitochondrial Function in Severe Inflammation.

JPEN J Parenter Enteral Nutr. 2013 May 23.

www.ncbi.nlm.nih.gov/pubmed/23703093

Doehn JM, Fischer K, Reppe K, Gutbier B, Tschernig T, Hocke AC, Fischetti VA, Löffler J, Suttorp N, Hippenstiel S, Witzenrath M.

Delivery of the endolysin Cpl-1 by inhalation rescues mice with fatal pneumococcal pneumonia.

J Antimicrob Chemother. 2013 Sep;68(9):2111-7. doi: 10.1093/jac/dkt131. Epub 2013 Apr 30.

www.ncbi.nlm.nih.gov/pubmed/23633685

Müller-Redetzky HC, Kummer W, Pfeil U, Hellwig K, Will D, Paddenberg R, Tabeling C, Hippenstiel S, Suttorp N, Witzenrath M.

Intermedin stabilized endothelial barrier function and attenuated ventilator-induced lung injury in mice.

PLoS One. 2012;7(5):e35832. Epub 2012 May 1.

www.ncbi.nlm.nih.gov/pubmed/22563471

Koppe U, Högner K, Witzenrath M, Bauer S, Hammerschmidt S, Suttorp N, Herold S, Opitz B.

Streptococcus pneumoniae stimulates a STING- and IFN regulatory factor 3-dependent type I IFN production in macrophages, which regulates RANTES production in macrophages, cocultured alveolar epithelial cells, and mouse lungs.

J Immunol. 2012 Jan 15;188(2):811-7

www.ncbi.nlm.nih.gov/pubmed/22156592

Lippmann J, Müller H, Naujoks J, Tabeling C, Shin S, Witzenrath M, Hellwig K, Kirschning CJ, Taylor GA, Barchet W, Bauer S, Suttorp N, Roy CR, Opitz B

Dissection of a type I interferon pathway in controlling bacterial intracellular infection in mice.

Cell Microbiol. 2011 Nov;13(11):1668-82. doi: 10.1111/j.1462-5822.2011.01646.x. Epub 2011 Aug 24

www.ncbi.nlm.nih.gov/pubmed/21790939

Müller HC, Hocke AC, Hellwig K, Gutbier B, Peters H, Schönrock SM, Tschernig T, Schmiedl A, Hippenstiel S, N´Guessan PD, Rosseau S, Suttorp N, Witzenrath M.

The Sphingosine-1 Phosphate receptor agonist FTY720 dose dependently affected endothelial integrity in vitro and aggravated ventilator-induced lung injury in mice.

Pulm Pharmacol Ther. 2011 Aug;24(4):377-85. doi: 10.1016/j.pupt.2011.01.017. Epub 2011 Mar 23.

www.ncbi.nlm.nih.gov/pubmed/21419858

Witzenrath M, Pache F, Lorenz D, Koppe U, Schönrock S, Meixenberger K, Dorhoi A, Ma J, Holmes A, Trendelenburg G, Heimesaat MM, Bereswill S, van der Linden M, Tschopp J, Mitchell TJ, Suttorp N, Opitz B.

The NLRP3 Inflammasome is Differentially Activated by Pneumolysin Variants and Contributes to Host Defense in Pneumococcal Pneumonia.

J Immunol. 2011 Jul 1;187(1):434-40. Epub 2011 Jun 6.

www.ncbi.nlm.nih.gov/pubmed/21646297

Müller HC, Witzenrath M, Tschernig T, Gutbier B, Hippenstiel S, Santel A, Suttorp N, Rosseau S.

Adrenomedullin attenuates ventilator-induced lung injury in mice.

Thorax. 2010 Dec;65(12):1077-84. Epub 2010 Oct 22

www.ncbi.nlm.nih.gov/pubmed/20971983

Müller HC, Hellwig K, Rosseau S, Tschernig T, Schmiedl A, Gutbier B, Schmeck B, Hippenstiel S, Peters H, Morawietz L, Suttorp N, Witzenrath M.

Simvastatin attenuates ventilator-induced lung injury in mice.

Crit Care. 2010 14(4):R143. Epub 2010 Jul 30.

www.ncbi.nlm.nih.gov/pubmed/20673352

Zahlten J, Steinicke R, Opitz B, Eitel J, N´guessan PD, Vinzing M, Witzenrath M, Schmeck B, Hammerschmidt S, Suttorp N, Hippenstiel S.

TLR2- and nucleotide-binding oligomerization domain 2-dependent Krüppel-like factor 2 expression downregulates NF-kappa B-related gene expression.

J Immunol. 2010 Jul 1;185(1):597-604. Epub 2010 Jun 4

www.ncbi.nlm.nih.gov/pubmed/20525885

Gutbier B, Kube SM, Reppe K, Santel A, Lange C, Kaufmann J, Suttorp N, Witzenrath M.

RNAi-mediated suppression of constitutive pulmonary gene expression by small interfering RNA in mice.

Pulm Pharmacol Ther. 2010 Aug;23(4):334-44. Epub 2010 Apr 1.

www.ncbi.nlm.nih.gov/pubmed/20362688