Vidakovic L, Mikhaleva S, Jeckel H, Nisnevich V, Strenger K, Neuhaus K, Raveendran K, Ben-Moshe NB, Aznaourova M, Nosho K, Drescher A, Schmeck B, Schulte LN, Persat A, Avraham R, Drescher K.

Biofilm formation on human immune cells is a multicellular predation strategy of Vibrio cholerae

Cell. 2023 Jun 8;186(12):2690-2704.e20. doi: 10.1016/j.cell.2023.05.008. https://pubmed.ncbi.nlm.nih.gov/37295405/

Del Fresno C, Schulte LN, López-Collazo E.

Role of hypoxia-inducible factors in metabolic immune cell adaptation during sepsis.

Front Immunol. 2023 Apr 18;14:1194504. https://pubmed.ncbi.nlm.nih.gov/37143647/

Bierwagen J, Wiegand M, Laakmann K, Danov O, Limburg H, Herbel SM, Heimerl T, Dorna J, Jonigk D, Preußer C, Bertrams W, Braun A, Sewald K, Schulte LN, Bauer S, Pogge von Strandmann E, Böttcher-Friebertshäuser E, Schmeck B, Jung AL.

Bacterial vesicles block viral replication in macrophages via TLR4-TRIF-axis.

Cell Commun Signal. 2023 Mar 28;21(1):65. https://pubmed.ncbi.nlm.nih.gov/36978183/

Jung AL, Møller Jørgensen M, Bæk R, Artho M, Griss K, Han M, Bertrams W, Greulich T, Koczulla R, Hippenstiel S, Heider D, Suttorp N, Schmeck B.

Surface proteome of plasma extracellular vesicles as mechanistic and clinical biomarkers for malaria.

Infection. 2023 Mar 24. doi: 10.1007/s15010-023-02022-x. https://pubmed.ncbi.nlm.nih.gov/36961624/

Aznaourova M, Schmerer N, Janga H, Zhang Z, Pauck K, Bushe J, Volkers SM, Wendisch D, Georg P, Ntini E, Aillaud M, Gündisch M, Mack E, Skevaki C, Keller C, Bauer C, Bertrams W, Marsico A, Nist A, Stiewe T, Gruber AD, Ruppert C, Li Y, Garn H, Sander LE, Schmeck B, Schulte LN.

Single-cell RNA sequencing uncovers the nuclear decoy lincRNA PIRAT as a regulator of systemic monocyte immunity during COVID-19

Proc Natl Acad Sci USA. 2022 Sep 6;119(36):e2120680119. doi: 10.1073/pnas.2120680119. Epub 2022 Aug 23. https://pubmed.ncbi.nlm.nih.gov/35998224/

Hoffmann K, Obermayer B, Hönzke K, Fatykhova D, Demir Z, Löwa A, Alves LGT, Wyler E, Lopez-Rodriguez E, Mieth M, Baumgardt M, Hoppe J, Firsching TC, Tönnies M, Bauer TT, Eggeling S, Tran HL, Schneider P, Neudecker J, Rückert JC, Gruber AD, Ochs M, Landthaler M, Beule D, Suttorp N, Hippenstiel S, Hocke AC, Kessler M.

Human alveolar progenitors generate dual lineage bronchioalveolar organoids

Commun Biol. 2022 Aug 25;5(1):875. doi: 10.1038/s42003-022-03828-5. https://pubmed.ncbi.nlm.nih.gov/36008580/

Kazmierski J, Friedmann K, Postmus D, Emanuel J, Fischer C, Jansen J, Richter A, Bosquillon de Jarcy L, Schüler C, Sohn M, Sauer S, Drosten C, Saliba AE, Sander LE, Müller MA, Niemeyer D, Goffinet C.

Nonproductive exposure of PBMCs to SARS-CoV-2 induces cell-intrinsic innate immune responses

Mol Syst Biol. 2022 Aug;18(8):e10961. doi: 10.15252/msb.202210961. https://pubmed.ncbi.nlm.nih.gov/35975552/

Schmiedeknecht K, Kaufmann A, Bauer S, Venegas Solis F.

L-lactate as an indicator for cellular metabolic status: An easy and cost-effective colorimetric L-lactate assay

PLoS One. 2022 Jul 22;17(7):e0271818. doi: 10.1371/journal.pone.0271818. https://pubmed.ncbi.nlm.nih.gov/35867690/

Wygrecka M, Birnhuber A, Seeliger B, Michalick L, Pak O, Schultz AS, Schramm F, Zacharias M, Gorkiewicz G, David S, Welte T, Schmidt JJ, Weissmann N, Schermuly RT, Barreto G, Schaefer L, Markart P, Brack MC, Hippenstiel S, Kurth F, Sander LE, Witzenrath M, Kuebler WM, Kwapiszewska G, Preissner KT.

Altered fibrin clot structure and dysregulated fibrinolysis contribute to thrombosis risk in severe COVID-19

Blood Adv. 2022 Feb 8;6(3):1074-1087.  doi: 10.1182/bloodadvances.2021004816. pubmed.ncbi.nlm.nih.gov/34861681/

Georg P, Astaburuaga-García R, Bonaguro L, Brumhard S, Michalick L, Lippert LJ, Kostevc T, Gäbel C, Schneider M, Streitz M, Demichev V, Gemünd I, Barone M, Tober-Lau P, Helbig ET, Hillus D, Petrov L, Stein J, Dey HP, Paclik D, Iwert C, Mülleder M, Aulakh SK, Djudjaj S, Bülow RD, Mei HE, Schulz AR, Thiel A, Hippenstiel S, Saliba AE, Eils R, Lehmann I, Mall MA, Stricker S, Röhmel J, Corman VM, Beule D, Wyler E, Landthaler M, Obermayer B, von Stillfried S, Boor P, Demir M, Wesselmann H, Suttorp N, Uhrig A, Müller-Redetzky H, Nattermann J, Kuebler WM, Meisel C, Ralser M, Schultze JL, Aschenbrenner AC, Thibeault C, Kurth F, Sander LE, Blüthgen N, Sawitzki B; PA-COVID-19 Study Group.

Complement activation induces excessive T cell cytotoxicity in severe COVID-19

Cell. 2022 Feb 3;185(3):493-512.e25.  doi: 10.1016/j.cell.2021.12.040.  Epub 2021 Dec 28. pubmed.ncbi.nlm.nih.gov/35032429/

Obermann HL, Lederbogen II, Steele J, Dorna J, Sander LE, Engelhardt K, Bakowsky U, Kaufmann A, Bauer S.

RNA-Cholesterol Nanoparticles Function as Potent Immune Activators via TLR7 and TLR8

Front Immunol. 2022 Jan 21;12:658895. doi: 10.3389/fimmu.2021.658895. eCollection 2021. https://pubmed.ncbi.nlm.nih.gov/35126343/

Demichev V, Tober-Lau P, Nazarenko T, Lemke O, Kaur Aulakh S, Whitwell HJ, Röhl A, Freiwald A, Mittermaier M, Szyrwiel L, Ludwig D, Correia-Melo C, Lippert LJ, Helbig ET, Stubbemann P, Olk N, Thibeault C, Grüning NM, Blyuss O, Vernardis S, White M, Messner CB, Joannidis M, Sonnweber T, Klein SJ, Pizzini A, Wohlfarter Y, Sahanic S, Hilbe R, Schaefer B, Wagner S, Machleidt F, Garcia C, Ruwwe-Glösenkamp C, Lingscheid T, Bosquillon de Jarcy L, Stegemann MS, Pfeiffer M, Jürgens L, Denker S, Zickler D, Spies C, Edel A, Müller NB, Enghard P, Zelezniak A, Bellmann-Weiler R, Weiss G, Campbell A, Hayward C, Porteous DJ, Marioni RE, Uhrig A, Zoller H, Löffler-Ragg J, Keller MA, Tancevski I, Timms JF, Zaikin A, Hippenstiel S, Ramharter M, Müller-Redetzky H, Witzenrath M, Suttorp N, Lilley K, Mülleder M, Sander LE; PA-COVID-19 Study group; Kurth F, Ralser M.

A proteomic survival predictor for COVID-19 patients in intensive care.

PLOS Digit Health. 2022 Jan 18;1(1):e0000007. doi: 10.1371/journal.pdig.0000007. https://pubmed.ncbi.nlm.nih.gov/36812516/

Wendisch D, Dietrich O, Mari T, von Stillfried S, Ibarra IL, Mittermaier M, Mache C, Chua RL, Knoll R, Timm S, Brumhard S, Krammer T, Zauber H, Hiller AL, Pascual-Reguant A, Mothes R, Bülow RD, Schulze J, Leipold AM, Djudjaj S, Erhard F, Geffers R, Pott F, Kazmierski J, Radke J, Pergantis P, Baßler K, Conrad C, Aschenbrenner AC, Sawitzki B, Landthaler M, Wyler E, Horst D; Deutsche COVID-19 OMICS Initiative (DeCOI), Hippenstiel S, Hocke A, Heppner FL, Uhrig A, Garcia C, Machleidt F, Herold S, Elezkurtaj S, Thibeault C, Witzenrath M, Cochain C, Suttorp N, Drosten C, Goffinet C, Kurth F, Schultze JL, Radbruch H, Ochs M, Eils R, Müller-Redetzky H, Hauser AE, Luecken MD, Theis FJ, Conrad C, Wolff T, Boor P, Selbach M, Saliba AE, Sander LE.

SARS-CoV-2 infection triggers profibrotic macrophage responses and lung fibrosis.

Cell. 2021 Nov 27:S0092-8674(21)01383-0. doi: 10.1016/j.cell.2021.11.033. Epub ahead of print. PMID: 34914922. pubmed.ncbi.nlm.nih.gov/34914922/

Witkowski M, Tizian C, Ferreira-Gomes M, Niemeyer D, Jones TC, Heinrich F, Frischbutter S, Angermair S, Hohnstein T, Mattiola I, Nawrath P, Mc Ewen S, Zocche S, Viviano E, Heinz GA, Maurer M, Kölsch U, Chua RL, Aschman T, Meisel C, Radke J, Sawitzki B, Roehmel J, Allers K, Moos V, Schneider T, Hanitsch L, Mall MA, Conrad C, Radbruch H, Duerr CU, Trapani JA, Marcenaro E, Kallinich T, Corman VM, Kurth F, Sander LE, Drosten C, Treskatsch S, Durek P, Kruglov A, Radbruch A, Mashreghi MF, Diefenbach A.

Untimely TGFβ responses in COVID-19 limit antiviral functions of NK cells

Nature. 2021 Oct 25. doi: 10.1038/s41586-021-04142-6. Epub ahead of print. PMID: 34695836. pubmed.ncbi.nlm.nih.gov/34695836/

Loyal L, Braun J, Henze L, Kruse B, Dingeldey M, Reimer U, Kern F, Schwarz T, Mangold M, Unger C, Dörfler F, Kadler S, Rosowski J, Gürcan K, Uyar-Aydin Z, Frentsch M, Kurth F, Schnatbaum K, Eckey M, Hippenstiel S, Hocke A, Müller MA, Sawitzki B, Miltenyi S, Paul F, Mall MA, Wenschuh H, Voigt S, Drosten C, Lauster R, Lachman N, Sander LE, Corman VM, Röhmel J, Meyer-Arndt L, Thiel A, Giesecke-Thiel C.

Cross-reactive CD4+ T cells enhance SARS-CoV-2 immune responses upon infection and vaccination.

Science. 2021 Aug 31:eabh1823. doi: 10.1126/science.abh1823. Epub ahead of print. PMID: 34465633. pubmed.ncbi.nlm.nih.gov/34465633/

Hillus D, Schwarz T, Tober-Lau P, Vanshylla K, Hastor H, Thibeault C, Jentzsch S, Helbig ET, Lippert LJ, Tscheak P, Schmidt ML, Riege J, Solarek A, von Kalle C, Dang-Heine C, Gruell H, Kopankiewicz P, Suttorp N, Drosten C, Bias H, Seybold J; EICOV/COVIM Study Group, Klein F, Kurth F, Corman VM, Sander LE.

Safety, reactogenicity, and immunogenicity of homologous and heterologous prime-boost immunisation with ChAdOx1 nCoV-19 and BNT162b2: a prospective cohort study.

Lancet Respir Med. 2021 Aug 12:S2213-2600(21)00357-X. doi: 10.1016/S2213-2600(21)00357-X. Epub ahead of print. PMID: 34391547; PMCID: PMC8360702. pubmed.ncbi.nlm.nih.gov/34391547/

Schmerer N, Schulte LN.

Long noncoding RNAs in bacterial infection

Wiley Interdiscip Rev RNA. 2021 May 14:e1664. doi: 10.1002/wrna.1664. Epub ahead of print. PMID: 33989449. pubmed.ncbi.nlm.nih.gov/33989449/

Messner CB, Demichev V, Bloomfield N, Yu JSL, White M, Kreidl M, Egger AS, Freiwald A, Ivosev G, Wasim F, Zelezniak A, Jürgens L, Suttorp N, Sander LE, Kurth F, Lilley KS, Mülleder M, Tate S, Ralser M.

Ultra-fast proteomics with Scanning SWATH.

Nat Biotechnol. 2021 Mar 25. doi: 10.1038/s41587-021-00860-4. Online ahead of print. PMID: 33767396. pubmed.ncbi.nlm.nih.gov/33767396/

Perniss A, Schmidt P, Soultanova A, Papadakis T, Dahlke K, Voigt A, Schütz B, Kummer W, Deckmann K.

Development of epithelial cholinergic chemosensory cells of the urethra and trachea of mice

Cell Tissue Res. 2021 Feb 22. doi: 10.1007/s00441-021-03424-9. Epub ahead of print. PMID: 33616728. pubmed.ncbi.nlm.nih.gov/33616728/

Leister H, Luu M, Staudenraus D, Lopez Krol A, Mollenkopf H, Sharma A, Schmerer N, Schulte LN, Bertrams W, Schmeck B, Bosmann M, Steinhoff U, Visekruna A.

Pro- and anti-tumorigenic capacity of immunoproteasomes in shaping the tumor microenvironment

Cancer Immunol Res. 2021 Mar 11. doi: 10.1158/2326-6066.CIR-20-0492. Epub ahead of print. PMID: 33707310. pubmed.ncbi.nlm.nih.gov/33707310/

Linden G, Janga H, Franz M, Nist A, Stiewe T, Schmeck B, Vázquez O, Schulte LN.

Efficient antisense inhibition reveals microRNA-155 to restrain a late-myeloid inflammatory programme in primary human phagocytes

RNA Biol. 2021 Feb 23:1-15. doi: 10.1080/15476286.2021.1885209. Epub ahead of print. PMID: 33622174. pubmed.ncbi.nlm.nih.gov/33622174/

Aznaourova M, Schmerer N, Schmeck B, Schulte LN.

Disease-Causing Mutations and Rearrangements in Long Non-coding RNA Gene Loci

Front Genet. 2020 Nov 30;11:527484. doi: 10.3389/fgene.2020.527484. PMID: 33329688; PMCID: PMC7735109.

pubmed.ncbi.nlm.nih.gov/33329688/

Walther K, Schulte LN.

The role of lncRNAs in innate immunity and inflammation

RNA Biol. 2020 Nov 19:1-17. doi: 10.1080/15476286.2020.1845505. Epub ahead of print. PMID: 33138685.

pubmed.ncbi.nlm.nih.gov/33138685/

Michalick L, Weidenfeld S, Grimmer B, Fatykhova D, Solymosi PD, Behrens F, Dohmen M, Brack MC, Schulz S, Thomasch E, Simmons S, Müller-Redetzky H, Suttorp N, Kurth F, Neudecker J, Toennies M, Bauer TT, Eggeling S, Corman VM, Hocke AC, Witzenrath M, Hippenstiel S, Kuebler WM.

Plasma mediators in patients with severe COVID-19 cause lung endothelial barrier failure

Eur Respir J. 2020 Nov 5;2002384. doi: 10.1183/13993003.02384-2020. Online ahead of print.

Karwelat D, Schmeck B, Ringel M, Benedikter BJ, Hübner K, Beinborn I, Maisner A, Schulte LN, Vollmeister E.

Influenza virus‐mediated suppression of bronchial Chitinase‐3‐like 1 secretion promotes secondary pneumococcal infection

FASEB J. 2020;00:1–17.

Jung S, von Thülen T, Yang I, Laukemper V, Rupf B, Janga H, Panagiotidis GD, Schoen A, Nicolai M, Schulte LN, Obermann HL, Weber F, Kaufmann A, Bauer S

A ribosomal RNA fragment with 2',3'-cyclic phosphate and GTP-binding activity acts as RIG-I ligand

Nucleic Acids Res. 2020 Oct 9;48(18):10397-10412. doi: 10.1093/nar/gkaa739.

Aznaourova M, Janga H, Sefried S, Kaufmann A, Dorna J, Volkers SM, Georg P, Lechner M, Hoppe J, Dökel S, Schmerer N, Gruber AD, Linne U, Bauer S, Sander LE, Schmeck B, Schulte LN

Noncoding RNA MaIL1 is an integral component of the TLR4–TRIF pathway.

Proc Natl Acad Sci U S A. 2020 Apr 2. pii: 201920393

Herkt CE, Caffrey BE, Surmann K, Blankenburg S, Gesell Salazar M, Jung AL, Herbel SM, Hoffmann K, Schulte LN, Chen W, Sittka-Stark A, Völker U, Vingron M, Marsico A, Bertrams W, Schmeck B.

A MicroRNA Network Controls Legionella pneumophila Replication in Human Macrophages via LGALS8 and MX1.

mBio. 2020 Mar 24;11(2). pii: e03155-19

Limburg H, Harbig A, Bestle D, Stein DA, Moulton HM, Jaeger J, Janga H, Hardes K, Koepke J, Schulte L, Koczulla AR, Schmeck B, Klenk HD, Böttcher-Friebertshäuser E.

TMPRSS2 is the major activating protease of influenza A virus in primary human airway cells and influenza B virus in human type II pneumocytes.

J Virol. 2019 Oct 15;93(21). pii: e00649-19

https://www.ncbi.nlm.nih.gov/pubmed/31391268

Scheller N, Herold S, Kellner R, Bertrams W, Jung AL, Janga H, Greulich T, Schulte LN, Vogelmeier CF, Lohmeyer J, Schmeck B

Proviral MicroRNAs Detected in Extracellular Vesicles From Bronchoalveolar Lavage Fluid of Patients With Influenza Virus-Induced Acute Respiratory Distress Syndrome.

J Infect Dis. 2019 Jan 29;219(4):540-543

https://www.ncbi.nlm.nih.gov/pubmed/30239899

Schulte LN, Bertrams W, Stielow C, Schmeck B

ncRNAs in Inflammatory and Infectious Diseases.

Methods Mol Biol. 2019;1912:3-32

https://www.ncbi.nlm.nih.gov/pubmed/30635888

Schulte LN, Heinrich B, Janga H, Schmeck BT, Vázquez O

A Far-Red Fluorescent DNA Binder for Interaction Studies of Live Multidrug-Resistant Pathogens and Host.

Cells. Angew Chem Int Ed Engl. 2018 Sep 3;57(36):11564-11568

https://www.ncbi.nlm.nih.gov/pubmed/29972713