Transregio SFB-TR 84 “Innate Immunity of the Lung: Mechanisms of Pathogen Attack and Host Defence in Pneumonia“

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Publications

C1 Publications

Scheller N, Herold S, Kellner R, Bertrams W, Jung AL, Janga H, Greulich T, Schulte LN, Vogelmeier CF, Lohmeyer J, Schmeck B.

Pro-viral miRNAs detected in BALF extracellular vesicles of patients with influenza virus-induced ARDS.

J Infect Dis. 2018 Sep 15

www.ncbi.nlm.nih.gov/pubmed/30239899

Schulte LN, Heinrich B, Janga H, Schmeck BT, Vázquez O

A Far-Red Fluorescent DNA Binder for Interaction Studies of Live Multidrug-Resistant Pathogens and Host.

Cells. Angew Chem Int Ed Engl. 2018 Sep 3;57(36):11564-11568

www.ncbi.nlm.nih.gov/pubmed/29972713

Gutbier B, Schönrock SM, Ehrler C, Haberberger R, Dietert K, Gruber AD, Kummer W, Michalik L, Kübler WM, Hocke AC, Szymanski K, Letsiou E, Lüth A, Schumacher F, Kleuser B, Mitchell TJ, Bertrams W, Schmeck B, Treue D, Klauschen F, Bauer TT, Tönnies M, Weissmann N, Hippenstiel S, Suttorp N, Witzenrath M, CAPNETZ Study Group

Sphingosine kinase 1 regulates inflammation and contributes to acute lung injury in pneumococcal pneumonia via the S1P receptor 2.

Crit Care Med. 2018 Jan 2.

www.ncbi.nlm.nih.gov/pubmed/29298188

Schulz C, Lai X, Bertrams W, Jung AL, Sittka-Stark A, Herkt CE, Janga H, Zscheppang K, Stielow C, Schulte L, Hippenstiel S, Vera J, Schmeck B

THP-1-derived macrophages render lung epithelial cells hypo-responsive to Legionella pneumophila - a systems biology study.

Sci Rep. 2017 Sep 20;7(1):11988

www.ncbi.nlm.nih.gov/pubmed/28931863

Jung AL, Herkt CE, Schulz C, Bolte K, Seidel K, Scheller N, Sittka-Stark A, Bertrams W, Schmeck B

Legionella pneumophila infection activates bystander cells differentially by bacterial and host cell vesicles.

Sci Rep. 2017 Jul 24;7(1):6301

www.ncbi.nlm.nih.gov/pubmed/28740179

Jentho E, Bodden M, Schulz C, Jung AL, Seidel K, Schmeck B, Bertrams W

microRNA-125a-3p is regulated by MyD88 in Legionella pneumophila infection and targets NTAN1.

PLoS One. 2017 Apr 26;12(4):e0176204

www.ncbi.nlm.nih.gov/pubmed/28445535

Wentker P, Eberhardt M, Dreyer FS, Bertrams W, Cantone M, Griss K, Schmeck B, Vera J

An Interactive Macrophage Signal Transduction Map Facilitates Comparative Analyses of High-Throughput Data.

J Immunol. 2017 Mar 1;198(5):2191

www.ncbi.nlm.nih.gov/pubmed/28137890

Jung AL, Hoffmann K, Herkt CE, Schulz C, Bertrams W, Schmeck B

Legionella pneumophila Outer Membrane Vesicles: Isolation and Analysis of Their Pro-inflammatory Potential on Macrophages.

J Vis Exp. 2017 Feb 22;(120)

www.jove.com/video/55146/legionella-pneumophila-outer-membrane-vesicles-isolation-analysis

Du Bois I, Marsico A, Bertrams W, Schweiger MR, Caffrey BE, Sittka-Stark A, Eberhardt M, Vera J, Vingron M, Schmeck BT

Genome-wide Chromatin Profiling of Legionella pneumophila-Infected Human Macrophages Reveals Activation of the Probacterial Host Factor TNFAIP2.

J Infect Dis. 2016 Aug 1;214(3):454-63

www.ncbi.nlm.nih.gov/pubmed/27130431

Budach S, Heinig M, Marsico A

Principles of microRNA Regulation Revealed Through Modeling microRNA Expression Quantitative Trait Loci.

Genetics. 2016 Aug;203(4):1629-40

www.ncbi.nlm.nih.gov/pubmed/27260304

Jung AL, Stoiber C, Herkt CE, Schulz C, Bertrams W, Schmeck B

Legionella pneumophila-derived outer membrane vesicles promote bacterial replication in macrophages.

PLoS Pathog. 2016 Apr 22;12(4)

www.ncbi.nlm.nih.gov/pubmed/27105429

Griss K, Bertrams W, Sittka-Stark A, Seidel K, Stielow C, Hippenstiel S, Suttorp N, Eberhardt M, Wilhelm J, Vera J, Schmeck B

MicroRNAs constitute a negative feedback loop in Streptococcus pneumoniae induced macrophage activation.

J Infect Dis. 2016 Mar 16

www.ncbi.nlm.nih.gov/pubmed/26984146

Conrad T, Marsico A, Gehre M, Orom UA

Microprocessor activity controls differential miRNA biogenesis In Vivo.

Cell Rep. 2014 Oct 23;9(2):542-54

www.ncbi.nlm.nih.gov/pubmed/25310978

Marsico A, Huska MR, Lasserre J, Hu H, Vucicevic D, Musahl A, Orom UA, Vingron M.

PROmiRNA: a new miRNA promoter recognition method uncovers the complex regulation of intronic miRNAs.

Genome Biol. 2013 Aug 16;14(8)

genomebiology.com/2013/14/8/R84

von Deetzen MC, Schmeck B, Gruber AD, Klopfleisch R.

Molecular quantification of canine specific microRNA species.

Res Vet Sci. 2013 Oct;95(2):562-8. Epub 2013 Jul 22.

www.ncbi.nlm.nih.gov/pubmed/23886399

Sittka A, Schmeck B.

MicroRNAs in the lung.

Adv Exp Med Biol. 2013;774:121-34. doi: 10.1007/978-94-007-5590-1_7. Review.

www.ncbi.nlm.nih.gov/pubmed/23377971

Zahlten J, Steinicke R, Bertrams W, Hocke AC, Scharf S, Schmeck B, Witzenrath M, Hammerschmidt S, Suttorp N, Hippenstiel S.

TLR9- and Src-dependent expression of Krueppel-like factor 4 controls interleukin-10 expression in pneumonia.

Eur Respir J. 2013 Feb;41(2):384-91. Epub 2012 May 31

www.ncbi.nlm.nih.gov/pubmed/22653776

Sittka A, Vera J, Lai X, Schmeck BT.

Asthma phenotyping, therapy, and prevention: what can we learn from systems biology?

Pediatr Res. 2013 Apr;73(4 Pt 2):543-52. doi: 10.1038/pr.2013.8. Epub 2013 Jan 11. Review.

www.ncbi.nlm.nih.gov/pubmed/

Fuellen G, Dengjel J, Hoeflich A, Hoeijemakers J, Kestler HA, Kowald A, Priebe S, Rebholz-Schuhmann D, Schmeck B, Schmitz U, Stolzing A, Sühnel J, Wuttke D, Vera J.

Systems biology and bioinformatics in aging research: a workshop report.

Rejuvenation Res. 2012 Dec;15(6):631-41. doi: 10.1089/rej.2012.1360. Epub 2012 Nov 19.

www.ncbi.nlm.nih.gov/pubmed/

Eitel J, Meixenberger K, van Laak C, Orlovski C, Hocke A, Schmeck B, Hippenstiel S, N’Guessan PD, Suttorp N, Opitz B

Rac1 regulates the NLRP3 inflammasome which mediates IL-1beta production in Chlamydophila pneumoniae infected human mononuclear cells.

PLoS One. 2012;7(1):e30379. doi: 10.1371/journal.pone.0030379. Epub 2012 Jan 20.

www.ncbi.nlm.nih.gov/pubmed/22276187

Müller HC, Hellwig K, Rosseau S, Tschernig T, Schmiedl A, Gutbier B, Schmeck B, Hippenstiel S, Peters H, Morawietz L, Suttorp N, Witzenrath M.

Simvastatin attenuates ventilator-induced lung injury in mice.

Crit Care. 2010 14(4):R143. Epub 2010 Jul 30.

www.ncbi.nlm.nih.gov/pubmed/20673352

Lorenz J, Zahlten J, Pollok I, Lippmann J, Scharf S, N´Guessan PD, Opitz B, Flieger A, Suttorp N, Hippenstiel S, Schmeck B.

Legionella pneumophila-induced I?B?-dependent expression of interleukin-6 in lung epithelium.

Eur Respir J. 2011 Mar;37(3):648-57. Epub 2010 Jul 22.

www.ncbi.nlm.nih.gov/pubmed/20650996

Scharf S, Vardarova K, Lang F, Schmeck B, Opitz B, Flieger A, Heuner K, Hippenstiel S, Suttorp N, N´Guessan PD.

Legionella pneumophila induces human beta defensin-3 in pulmonary cells.

Respir Res. 2010 Jul 8;11:93.

www.ncbi.nlm.nih.gov/pubmed/20615218

Zahlten J, Steinicke R, Opitz B, Eitel J, N´guessan PD, Vinzing M, Witzenrath M, Schmeck B, Hammerschmidt S, Suttorp N, Hippenstiel S.

TLR2- and nucleotide-binding oligomerization domain 2-dependent Krüppel-like factor 2 expression downregulates NF-kappa B-related gene expression.

J Immunol. 2010 Jul 1;185(1):597-604. Epub 2010 Jun 4

www.ncbi.nlm.nih.gov/pubmed/20525885

Meixenberger K, Pache F, Eitel J, Schmeck B, Hippenstiel S, Slevogt H, N´Guessan P, Witzenrath M, Netea MG, Chakraborty T, Suttorp N, Opitz B.

Listeria monocytogenes-infected human peripheral blood mononuclear cells produce IL-1beta,depending on listeriolysin O and NLRP3.

J Immunol. 2010 Jan 15;184(2):922-30. Epub 2009 Dec 11.

www.ncbi.nlm.nih.gov/pubmed/20008285