Transregio SFB-TR 84 “Innate Immunity of the Lung: Mechanisms of Pathogen Attack and Host Defence in Pneumonia“

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Publications

Scheller N, Herold S, Kellner R, Bertrams W, Jung AL, Janga H, Greulich T, Schulte LN, Vogelmeier CF, Lohmeyer J, Schmeck B.

Pro-viral miRNAs detected in BALF extracellular vesicles of patients with influenza virus-induced ARDS.

J Infect Dis. 2018 Sep 15

www.ncbi.nlm.nih.gov/pubmed/30239899

Kalymbetova TV, Selvakumar B, Rodriguez-Castillo JA, Gunjak M, Malainou C, Heindl MR, Moiseenko A, Chao CM, Vadasz I, Mayer K, Lohmeyer J, Bellusci S, Bottcher-Friebertshauser E, Seeger W, Herold S, Morty RE

Resident alveolar macrophages are master regulators of arrested alveolarization in experimental bronchopulmonary dysplasia.

J Pathol. 2018 Jun;245(2):153-159

onlinelibrary.wiley.com/doi/epdf/10.1002/path.5076

Herta T, Bhattacharyya A, Bollensdorf C, Kabus C, García P, Suttorp N, Hippenstiel S, Zahlten J

DNA-release by Streptococcus pneumoniae autolysin LytA induced Krueppel-like factor 4 expression in macrophages.

Sci Rep. 2018 Apr 10;8(1):5723

www.ncbi.nlm.nih.gov/pubmed/29636524

Perniss A, Schmidt N, Gurtner C, Dietert K, Schwengers O, Weigel M, Hempe J, Ewers C, Pfeil U, Gärtner U, Gruber AD, Hain T, Kummer W

Bordetella pseudohinzii targets cilia and impairs tracheal cilia-driven transport in naturally acquired infection in mice.

Sci Rep. 2018 Apr 9;8(1):5681

www.nature.com/articles/s41598-018-23830-4

Dittrich AS, Kühbandner I, Gehrig S, Rickert-Zacharias V, Twigg M, Wege S, Taggart CC, Herth F, Schultz C, Mall MA

Elastase activity on sputum neutrophils correlates with severity of lung disease in cystic fibrosis.

Eur Respir J. 2018 Mar 29;51(3). pii: 1701910

www.ncbi.nlm.nih.gov/pubmed/29545279

Ugolini M, Gerhard J, Burkert S, Jensen KJ, Georg P, Ebner F, Thada S, Dietert K, Helbig ET, Opitz B, Kurth F, Dittrich N, Sumanlatha G, Blander JM, Gruber AD, Hartmann S, Boekschoten MV, Suttorp N, Müller M, Jungersen G, Schumann RR, Sander LE

Recognition of microbial viability via TLR8 promotes T follicular helper cell differentiation and vaccine responses.

Nat Immunol  2018

www.nature.com/articles/s41590-018-0068-4

Dames C, Winek K, Beckers Y, Engel O, Meisel M, Meisel C

Immunomodulatory treatment with systemic GM-CSF augments pulmonary immune responses and improves neurological outcome after experimental stroke.

J Neuroimmunol. 2018 Mar 9. pii: S0165-5728(17)30548-9

www.jni-journal.com/article/S0165-5728(17)30548-9/fulltext

Gutbier B, Neuhauß AK, Reppe K, Ehrler C, Santel A, Kaufmann J, Scholz M, Weissmann N, Morawietz L, Mitchell TJ, Aliberti S, Hippenstiel S, Suttorp N, Witzenrath M; CAPNETZ and PROGRESS study groups

Prognostic and Pathogenic Role of Angiopoietin-1 and -2 in Pneumonia.

Am J Respir Crit Care Med. 2018 Feb 15

www.ncbi.nlm.nih.gov/pubmed/29447449

Tung QN, Linzner N, Loi VV, Antelmann H

Application of genetically encoded redox biosensors to measure dynamic changes in the glutathione, bacillithiol and mycothiol redox potentials in pathogenic bacteria.

Free Radic Biol Med. 2018 Feb 15. pii: S0891-5849(18)30073-X.

www.sciencedirect.com/science/article/pii/S089158491830073X

Shrivastav A, Dabrowski AN, Conrad C, Baal N, Hackstein H, Plog S, Dietert K, Gruber AD, N'Guessan PD, Aly S, Suttorp N, Zahlten J

Peptidoglycan Recognition Protein 3 Does Not Alter the Outcome of Pneumococcal Pneumonia in Mice.

Front Microbiol. 2018 Feb 1;9:103

www.ncbi.nlm.nih.gov/pubmed/29449834

Becker SC, Szyska M, Mensen A, Hellwig K, Otto R, Olfe L, Volk HD, Dörner T, Dörken B, Scheibenbogen C, Schröder J, Hocke AC, Kang Na Il

A comparative analysis of human bone marrow-resident and peripheral memory B cells.

J Allergy Clin Immunol. 2018 Jan 31

www.ncbi.nlm.nih.gov/pubmed/29355676

 

Dietert K, Nouailles G, Gutbier B, Reppe K, Berger S, Jiang X, Schauer AE, Hocke AC, Herold S, Slevogt H, Witzenrath M, Suttorp N, Gruber AD

Digital Image Analyses on Whole Lung Slides in Mouse Models of Acute Pneumonia.

Am J Respir Cell Mol Biol. 2018 Jan 23.

www.atsjournals.org/doi/full/10.1165/rcmb.2017-0337MA

Nerlich A, Mieth M, Letsiou E, Fatykhova D, Zscheppang K, Matsushima AI, Meyer TF, Paasch L, Mitchell T, Tönnies M, Bauer TT, Schneider P, Neudecker J, Rückert J, Eggeling S, Schimek M, Witzenrath M, Suttorp N, Hippenstiel S, Hocke AC

Pneumolysin induced mitochondrial dysfunction leads to release of mitochondrial DNA.

Scientific Reports (2018) 8:182

www.nature.com/articles/s41598-017-18468-7

Gutbier B, Schönrock SM, Ehrler C, Haberberger R, Dietert K, Gruber AD, Kummer W, Michalik L, Kübler WM, Hocke AC, Szymanski K, Letsiou E, Lüth A, Schumacher F, Kleuser B, Mitchell TJ, Bertrams W, Schmeck B, Treue D, Klauschen F, Bauer TT, Tönnies M, Weissmann N, Hippenstiel S, Suttorp N, Witzenrath M, CAPNETZ Study Group

Sphingosine kinase 1 regulates inflammation and contributes to acute lung injury in pneumococcal pneumonia via the S1P receptor 2.

Crit Care Med. 2018 Jan 2.

www.ncbi.nlm.nih.gov/pubmed/29298188

Boutin S, Depner M, Stahl M, Graeber SY, Dittrich SA, Legatzki A, von Mutius E, Mall M, Dalpke AH

Comparison of Oropharyngeal Microbiota from Children with Asthma and Cystic Fibrosis.

Mediators Inflamm. 2017;2017:5047403

www.ncbi.nlm.nih.gov/pubmed/29445257

Heß N, Waldow F, Kohler TP, Rohde M, Kreikemeyer B, Gómez-Mejia A, Hain T, Schwudke D, Vollmer W, Hammerschmidt S, Gisch N

LTA deficiency permits normal growth but impairs virulence of Streptococcus pneumoniae.

Nat Commun. 2017 Dec 12;8(1):2093

www.ncbi.nlm.nih.gov/pubmed/29233962

Horn V, Triantafyllopoulou A

DNA damage signaling and polyploid macrophages in chronic inflammation.

Curr Opin Immunol. 2017 Dec 1;50:55-63

www.ncbi.nlm.nih.gov/pubmed/29202328

Dietert K, Gutbier B, Wienhold SM, Reppe K, Jiang X, Yao L, Chaput C, Naujoks J, Brack M, Kupke A, Peteranderl C, Becker S, von Lachner C, Baal N, Slevogt H, Hocke AC, Witzenrath M, Opitz B, Herold S, Hackstein H, Sander LE, Suttorp N, Gruber AD

Spectrum of pathogen- and model-specific histopathologies in mouse models of acute pneumonia.

PLoS One. 2017 Nov 20;12(11):e0188251

www.ncbi.nlm.nih.gov/pubmed/29155867

van de Sandt CE, Bárcena M, Koster AJ, Kasper J, Kirkpatrick CJ, Scott DP, de Vries RD, Herold S, Rimmelzwaan GF, Kuiken T, Short KR

Human CD8+ T Cells Damage Noninfected Epithelial Cells during Influenza Virus Infection In Vitro.

Am J Respir Cell Mol Biol. 2017 Nov;57(5):536-546

www.ncbi.nlm.nih.gov/pubmed/28613916

Boutin S, Graeber SY, Stahl M, Dittrich AS, Mall MA, Dalpke AH

Chronic but not intermittent infection with Pseudomonas aeruginosa is associated with global changes of the lung microbiome in cystic fibrosis.

Eur Respir J. 2017 Oct 5;50(4)

www.ncbi.nlm.nih.gov/pubmed/28982777

Schulz C, Lai X, Bertrams W, Jung AL, Sittka-Stark A, Herkt CE, Janga H, Zscheppang K, Stielow C, Schulte L, Hippenstiel S, Vera J, Schmeck B

THP-1-derived macrophages render lung epithelial cells hypo-responsive to Legionella pneumophila - a systems biology study.

Sci Rep. 2017 Sep 20;7(1):11988

www.ncbi.nlm.nih.gov/pubmed/28931863

Zscheppang K, Berg J, Hedtrich S, Verheyen L, Wagner DE, Suttorp N, Hippenstiel S, Hocke AC

Human pulmonary 3D models for translational research.

Biotechnol J. 2017 Sep 2

www.ncbi.nlm.nih.gov/pubmed/28865134

Wygrecka M, Kosanovic D, Wujak L, Reppe K, Henneke I, Frey H, Didiasova M, Kwapiszewska G, Marsh LM, Baal N, Hackstein H, Zakrzewicz D, Müller-Redetzky HC, de Maat S, Maas C, Nolte MW, Panousis C, Schermuly RT, Seeger W, Witzenrath M, Schaefer L, Markart P

Antihistone Properties of C1 Esterase Inhibitor Protect against Lung Injury.

Am J Respir Crit Care Med. 2017 Jul 15;196(2):186-199

www.ncbi.nlm.nih.gov/pubmed/28005404

Berg J, Zscheppang K, Fatykhova D, Tönnies M, Bauer TT, Schneider P, Neudecker J, Rückert JC, Eggeling S, Schimek M, Gruber AD, Suttorp N, Hippenstiel S, Hocke AC

Tyk2 as a target for immune regulation in human viral/bacterial pneumonia.

Eur Respir J. 2017 Jul 13;50(1)

erj.ersjournals.com/content/50/1/1601953

Peter A, Fatykhova D, Kershaw O, Gruber AD, Rueckert J, Neudecker J, Toennies M, Bauer TT, Schneider P, Schimek M, Eggeling S, Suttorp N, Hocke AC, Hippenstiel S

Localization and pneumococcal alteration of junction proteins in the human alveolar-capillary compartment.

Histochem Cell Biol. 2017 Jun;147(6):707-719

www.ncbi.nlm.nih.gov/pubmed/28247028

Lippitsch A, Chukovetskyi Y, Baal N, Bein G, Hackstein H

Unique high and homogenous surface expression of the transferrin receptor CD71 on murine plasmacytoid dendritic cells in different tissues.

Cell Immunol. 2017 Jun;316:41-52

doi.org/10.1016/j.cellimm.2017.03.005

Gerlach T, Hensen L, Matrosovich T, Bergmann J, Winkler M, Peteranderl C, Klenk HD, Weber F, Herold S, Pöhlmann S, Matrosovich M

pH Optimum of Hemagglutinin-Mediated Membrane Fusion Determines Sensitivity of Influenza A Viruses to the Interferon-Induced Antiviral State and IFITMs.

J Virol. 2017 May 12;91(11). pii: e00246-17

www.ncbi.nlm.nih.gov/pubmed/28356532

Peteranderl C, Sznajder JI, Herold S and Lecuona E

Inflammatory responses regulating alveolar ion transport during pulmonary infections.

Front Immunol. 2017 Apr 18;8:446

www.ncbi.nlm.nih.gov/pubmed/28458673

Peteranderl C, Herold S

The Impact of the Interferon/TNF-Related Apoptosis-Inducing Ligand Signaling Axis on Disease Progression in Respiratory Viral Infection and Beyond.

Front Immunol. 2017 Mar 22;8:313

www.ncbi.nlm.nih.gov/pubmed/28382038

Sadewasser A, Paki K, Eichelbaum K, Bogdanow B, Saenger S, Budt M, Lesch M, Hinz KP, Herrmann A, Meyer TF, Karlas A, Selbach M, Wolff T

Quantitative proteomic approach identifies Vpr binding protein as novel host factor supporting influenza A virus infections in human cells.

Mol Cell Proteomics. 2017 Mar 13

www.ncbi.nlm.nih.gov/pubmed/28289176

Schierhorn KL, Jolmes F, Bespalowa J, Saenger S, Peteranderl C, Dzieciolowski J, Budt M, Pleschka S, Herrmann A, Herold S, Wolff T

Influenza A virus virulence depends on two amino acids in the N-terminal domain of its NS1 protein facilitating inhibition of PKR.

J Virol. 2017 Mar 1. pii: JVI.00198-17

www.ncbi.nlm.nih.gov/pubmed/28250123

Hocke AC, Suttorp N, and Hippenstiel S

Human lung ex vivo infection models.

Cell Tissue Res. 2017 Mar;367(3):511-524

www.ncbi.nlm.nih.gov/pubmed/27999962

Chao CM, Yahya F, Moiseenko A, Tiozzo C, Shrestha A, Ahmadvand N, El Agha E, Quantius J, Dilai S, Kheirollahi V, Jones M, Wilhem J, Carraro G, Ehrhardt H, Zimmer KP, Barreto G, Ahlbrecht K, Morty RE, Herold S, Abellar RG, Seeger W, Schermuly R, Zhang JS, Minoo P, Bellusci S

Fgf10 deficiency is causative for lethality in a mouse model of bronchopulmonary dysplasia.

J Pathol. 2017 Jan;241(1):91-103

www.ncbi.nlm.nih.gov/pubmed/27770432

Schaefer MB, Schaefer CA, Schifferings S, Kuhlmann CR, Urban A, Benscheid U, Fischer T, Hecker M, Morty RE, Vadasz I, Herold S, Witzenrath M, Seeger W, Erdogan A, Mayer K

N-3 vs. n-6 fatty acids differentially influence calcium signalling and adhesion of inflammatory activated monocytes: impact of lipid rafts.

Inflamm Res. 2016 Nov;65(11):881-894

www.ncbi.nlm.nih.gov/pubmed/27384606

Peteranderl C, Herold S, Schmoldt C

Human Influenza Virus Infections.

Semin Respir Crit Care Med. 2016 Aug;37(4):487-500

www.ncbi.nlm.nih.gov/pubmed/27486731

Rabes A, Suttorp N, Opitz B

Inflammasomes in Pneumococcal Infection: Innate Immune Sensing and Bacterial Evasion Strategies.

Curr Top Microbiol Immunol. 2016;397:215-27

www.ncbi.nlm.nih.gov/pubmed/27460812

Hackstein H, Tschipakow I, Bein G, Nold P, Brendel C, Baal N

Contact-dependent abrogation of bone marrow-derived plasmacytoid dendritic cell differentiation by murine mesenchymal stem cells.

Biochem Biophys Res Commun. 2016 Jul 15;476(1):15-20

www.ncbi.nlm.nih.gov/pubmed/27233615

Quantius J, Schmoldt C, Vazquez-Armendariz AI, Becker C, El Agha E, Wilhelm J, Morty RE, Vadász I, Mayer K, Gattenloehner S, Fink L, Matrosovich M, Li X, Seeger W, Lohmeyer J, Bellusci S, Herold S

Influenza Virus Infects Epithelial Stem/Progenitor Cells of the Distal Lung: Impact on Fgfr2b-Driven Epithelial Repair.

PLoS Pathog. 2016 Jun 20;12(6):e1005544

www.ncbi.nlm.nih.gov/pubmed/27322618

Mostafa A, Abdelwhab el-SM, Slanina H, Hussein MA, Kuznetsova I, Schüttler CG, Ziebuhr J, Pleschka S

Phylogenetic analysis of human influenza A/H3N2 viruses isolated in 2015 in Germany indicates significant genetic divergence from vaccine strains.

Arch Virol. 2016 Jun;161(6):1505-15

www.ncbi.nlm.nih.gov/pubmed/26973232

Winek K, Engel O, Koduah P, Heimesaat MM, Fischer A, Bereswill S, Dames C, Kershaw O, Gruber AD, Curato C, Oyama N, Meisel C, Meisel A, Dirnagl U

Depletion of cultivatable gut microbiota by broad-spectrum antibiotic pretreatment worsens outcome after murine stroke.

Stroke. 2016 May;47(5):1354-63

www.ncbi.nlm.nih.gov/pubmed/27056982

Winek K, Engel O, Koduah P, Heimesaat MM, Fischer A, Bereswill S, Dames C, Kershaw O, Gruber AD, Curato C, Oyama N, Meisel C, Meisel A, Dirnagl U

Depletion of cultivatable gut microbiota by broad-spectrum antibiotic pretreatment worsens outcome after murine stroke.

Stroke. 2016 May;47(5):1354-63

www.ncbi.nlm.nih.gov/pubmed/27056982

Peteranderl C, Morales-Nebreda L, Selvakumar B, Lecuona E, Vadász I, Morty RE, Schmoldt C, Bespalowa J, Wolff T, Pleschka S, Mayer K, Gattenloehner S, Fink L, Lohmeyer J, Seeger W, Sznajder JI, Mutlu GM, Budinger GR, Herold S

Macrophage-epithelial paracrine crosstalk inhibits lung edema clearance during influenza infection.

J Clin Invest. 2016 Apr 1;126(4):1566-80

www.ncbi.nlm.nih.gov/pubmed/26999599

Griss K, Bertrams W, Sittka-Stark A, Seidel K, Stielow C, Hippenstiel S, Suttorp N, Eberhardt M, Wilhelm J, Vera J, Schmeck B

MicroRNAs constitute a negative feedback loop in Streptococcus pneumoniae induced macrophage activation.

J Infect Dis. 2016 Mar 16

www.ncbi.nlm.nih.gov/pubmed/26984146

Short K, Kasper J, van der Aa S, Andeweg AC, Zaaraoui-Boutahar F, Goeijenbier M, Richard M, Herold S, Becker C, Scott DP, Limpens R, Koster AJ, Barcena M, Fouchier R, Kirkpatrick CJ, Kuiken T

Influenza virus damages the alveolar barrier by disrupting epithelial cell tight junctions.

Eur Respir J. 2016 Mar;47(3):954-66

www.ncbi.nlm.nih.gov/pubmed/ 26743480

Naujoks J, Tabeling C, Dill BD, Hoffmann C, Brown AS, Kunze M, Kempa S, Peter A, Mollenkopf HJ, Dorhoi A, Kershaw O, Gruber AD, Sander LE, Witzenrath M, Herold S, Nerlich A, Hocke AC, van Driel I, Suttorp N, Bedoui S, Hilbi H, Trost M, Opitz B

IFNs Modify the Proteome of Legionella-Containing Vacuoles and Restrict Infection Via IRG1-Derived Itaconic Acid.

PLoS Pathog. 2016 Feb 1;12(2)

www.ncbi.nlm.nih.gov/pubmed/26829557

Hoffmann S, Harms H, Ulm L, Nabavi DG, Mackert BM, Schmehl I, Jungehulsing GJ, Montaner J, Bustamante A, Hermans M, Hamilton F, Göhler J, Malzahn U, Malsch C, Heuschmann PU, Meisel C, Meisel A

Stroke-induced immunodepression and dysphagia independently predict stroke-associated pneumonia - The PREDICT study.

J Cereb Blood Flow Metab. 2016 Jan 1:271678X16671964

www.ncbi.nlm.nih.gov/pubmed/27733675

Reppe K, Radünzel P, Dietert K, Tschernig T, Wolff T, Hammerschmidt S, Gruber AD, Suttorp N, Witzenrath M

Pulmonary immunostimulation with MALP-2 in influenza virus-infected mice increases survival after pneumococcal superinfection.

Infect Immun. 2015 Dec;83(12):4617-29

www.ncbi.nlm.nih.gov/pubmed/26371127

Meisel A, Smith CJ

Stroke: Preventive antibiotics for stroke-associated pneumonia.

Nat Rev Neurol. 2015 Nov 3

www.ncbi.nlm.nih.gov/pubmed/26526533

Engel O, Akyüz L, da Costa Goncalves AC, Winek K, Dames C, Thielke M, Herold S, Böttcher C, Priller J, Volk HD, Dirnagl U, Meisel C, Meisel A

Cholinergic pathway suppresses pulmonary innate immunity facilitating pneumonia after stroke.

Stroke. 2015 Nov;46(11):3232-40

www.ncbi.nlm.nih.gov/pubmed/26451017

Hackstein H, Lippitsch A, Krug P, Schevtschenko I, Kranz S, Hecker M, Dietert K, Gruber AD, Bein G, Brendel C, Baal N

Prospectively defined murine mesenchymal stem cells inhibit Klebsiella pneumoniae-induced acute lung injury and improve pneumonia survival.

Respir Res. 2015 Oct 6;16:123

www.ncbi.nlm.nih.gov/pubmed/26438075

Zahlten J, Herta T, Kabus C, Steinfeldt M, Kershaw O, García P, Hocke AC, Gruber AD, Hübner RH, Steinicke R, Doehn JM, Suttorp N, Hippenstiel S

Role of Pneumococcal Autolysin for KLF4 Expression and Chemokine Secretion in Lung Epithelium.

Am J Respir Cell Mol Biol. 2015 Oct;53(4):544-54

www.ncbi.nlm.nih.gov/pubmed/ 25756955

Meisel A, Smith CJ

Prevention of stroke-associated pneumonia: where next?

Lancet. 2015 Sep 3. pii: S0140-6736(15)00127-0

www.ncbi.nlm.nih.gov/pubmed/26343837

Fatykhova D, Rabes A, Machnik C, Guruprasad K, Pache F, Berg J, Toennies M, Bauer TT, Schneider P, Schimek M, Eggeling S, Mitchell TJ, Mitchell AM, Hilker R, Hain T, Suttorp N, Hippenstiel S, Hocke AC, Opitz B

Serotype 1 and 8 Pneumococci Evade Sensing by Inflammasomes in Human Lung Tissue.

PLoS One. 2015 Aug 28;10(8):e0137108

www.ncbi.nlm.nih.gov/pubmed/26317436

Recum-Knepper J, Sadewasser A, Weinheimer VK, Wolff T

Fluorescence-Activated Cell Sorting-Based Analysis Reveals an Asymmetric Induction of Interferon-Stimulated Genes in Response to Seasonal Influenza A Virus.

J Virol. 2015 Jul 15;89(14):6982-93

www.ncbi.nlm.nih.gov/pubmed/25903337

Smith CJ, Kishore AK, Vail A, Chamorro A, Garau J, Hopkins SJ, Di Napoli M, Kalra L, Langhorne P, Montaner J, Roffe C, Rudd AG, Tyrrell PJ, van de Beek D, Woodhead M, Meisel A.

Diagnosis of Stroke-Associated Pneumonia: Recommendations From the Pneumonia in Stroke Consensus Group.

Stroke. 2015 Jun 25. pii: STROKEAHA.115.009617.

www.ncbi.nlm.nih.gov/pubmed/26111886

Mühlbauer D, Dzieciolowski J, Hardt M, Hocke A, Schierhorn KL, Mostafa A, Müller C, Wisskirchen C, Herold S, Wolff T, Ziebuhr J, Pleschka S

Influenza virus-induced caspase-dependent enlargement of nuclear pores promotes nuclear export of viral ribonucleoprotein complexes.

J Virol. 2015 Jun 1;89(11):6009-21

www.ncbi.nlm.nih.gov/pubmed/25810542

Jung S, von Thulen T, Laukemper V, Pigisch S, Hangel D, Wagner H, Kaufmann A, Bauer S

A single naturally occurring 2'-O-methylation converts a TLR7- and TLR8-activating RNA into a TLR8-specific ligand.

A single naturally occurring 2'-O-methylation converts a TLR7- and TLR8-activating RNA into a TLR8-specific ligand.

www.ncbi.nlm.nih.gov/pubmed/25785446

Hecker M, Linder T, Ott J, Walmrath HD, Lohmeyer J, Vadász I, Marsh LM, Herold S, Reichert M, Buchbinder A, Morty RE, Bausch B, Fischer T, Schulz R, Grimminger F, Witzenrath M, Barnes M, Seeger W, Mayer K

Immunomodulation by lipid emulsions in pulmonary inflammation: a randomized controlled trial.

Crit Care. 2015 May 12;19:226

www.ncbi.nlm.nih.gov/pubmed/25962383

Müller-Redetzky HC, Wienhold SM, Berg J, Hocke AC, Hippenstiel S, Hellwig K, Gutbier B, Opitz B, Neudecker J, Rückert J, Gruber AC, Kershaw O, Mayer K,  Suttorp N, Witzenrath M

Moxifloxacin is not anti-inflammatory in experimental pneumococcal pneumonia.

J Antimicrob Chemother. 2015 Mar;70(3):830-40

www.ncbi.nlm.nih.gov/pubmed/25406299

Kishore AK, Vail A, Chamorro A, Garau J, Hopkins SJ, Di Napoli M, Kalra L, Langhorne P, Montaner J, Roffe C, Rudd AG, Tyrrell PJ, van de Beek D, Woodhead M, Meisel A, Smith CJ

How is pneumonia diagnosed in clinical stroke research? A systematic review and meta-analysis.

Stroke. 2015 May;46(5):1202-9.

www.ncbi.nlm.nih.gov/pubmed/25858238

Meisel A

Preventive antibiotic therapy in stroke: PASSed away?

Lancet. 2015 Apr 18;385(9977):1486-7

www.ncbi.nlm.nih.gov/pubmed/25612859

Tabeling C, Yu H, Wang L, Ranke H, Goldenberg NM, Zabini D, Noe E, Krauszman A, Gutbier B, Yin J, Schaefer M, Arenz C, Hocke AC, Suttorp N, Proia RL, Witzenrath M, Kuebler WM

CFTR and sphingolipids mediate hypoxic pulmonary vasoconstriction.

Proc Natl Acad Sci U S A. 2015 Mar 31;112(13):E1614-23

www.ncbi.nlm.nih.gov/pubmed/25829545

Zahlten J, Herta T, Kabus C, Steinfeldt M, Kershaw O, García P, Hocke AC, Gruber AD, Hübner RH, Steinicke R, Doehn JM, Suttorp N, Hippenstiel S

Pneumococci LytA-dependent KLF4 Expression Terminates IL-8 Secretion in Lung Epithelium.

Am J Respir Cell Mol Biol. 2015 Mar 10

www.ncbi.nlm.nih.gov/pubmed/25756955

Rabes A, Zimmermann S, Reppe K, Lang R, Seeberger PH, Suttorp N, Witzenrath M, Lepenies B, Opitz B

The C-type lectin receptor Mincle binds to Streptococcus pneumoniae but plays a limited role in the anti-pneumococcal innate immune response.

PLoS One. 2015 Feb 6;10(2):e0117022

www.ncbi.nlm.nih.gov/pubmed/25658823

Müller-Redetzky HC, Felten M, Hellwig K, Wienhold SM, Naujoks J, Opitz B, Kershaw O, Gruber AD, Suttorp N, Witzenrath M

Increasing the inspiratory time and I:E ratio during mechanical ventilation aggravates ventilator-induced lung injury in mice.

Critical Care 2015, 19:23

www.ncbi.nlm.nih.gov/pubmed/25888164

Zahlten J, Kim YJ, Doehn JM, Pribyl T, Hocke AC, García P, Hammerschmidt S, Suttorp N, Hippenstiel S, Hübner RH

Streptococcus pneumoniae-Induced Oxidative Stress in Lung Epithelial Cells Depends on Pneumococcal Autolysis and Is Reversible by Resveratrol.

J Infect Dis. 2015 Jun 1;211(11):1822-1830

www.ncbi.nlm.nih.gov/pubmed/25512625

Dames C, Akyüz L, Reppe K, Tabeling C, Dietert K, Kershaw O, Gruber AD, Meisel C, Meisel A, Witzenrath M, Engel O

Miniaturized bronchoscopy enables unilateral investigation, application, and sampling in mice.

Am J Respir Cell Mol Biol. 2014 Dec;51(6):730-7

www.ncbi.nlm.nih.gov/pubmed/24960575

Noe E, Tabeling C, Doehn JM, Naujoks J, Opitz B, Hippenstiel S, Witzenrath M, Klopfleisch R

Juvenile megaesophagus in PKCα-deficient mice is associated with an increase in the segment of the distal esophagus lined by smooth muscle cells.

Ann Anat. 2014 Sep;196(5):365-71

www.ncbi.nlm.nih.gov/pubmed/24862691

Hecker M, Ott J, Sondermann C, Schaefer M, Obert M, Hecker A, Morty RE, Vadasz I, Herold S, Rosengarten B, Witzenrath M, Seeger W, Mayer K

Immunomodulation by fish-oil containing lipid emulsions in murine acute respiratory distress syndrome.

Crit Care. 2014 Apr 29;18(2):R85

www.ncbi.nlm.nih.gov/pubmed/24780004

Peters DM, Vadász I, Wujak L, Wygrecka M, Olschewski A, Becker C, Herold S, Papp

TGF-ß directs trafficking of the epithelial sodium channel ENaC which has implications for ion and fluid transport in acute lung injury.

Proc Natl Acad Sci U S A. 2014 Jan 21;111(3):E374-83

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Inhaled GM-CSF as treatment of pneumonia-associated ARDS

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NOD1 Ligation Suppressed Murine Allergen-Specific T Cell Proliferation and Airway Hyperresponsiveness.

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J Biol Chem. 2013 Dec 17

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Knepper J, Schierhorn KL, Becher A, Budt M, Tönnies M, Bauer TT, Schneider P, Neudecker J, Rückert JC, Gruber AD, Suttorp N, Schweiger B, Hippenstiel S, Hocke AC, Wolff T

The novel human influenza A(H7N9) virus is naturally adapted to efficient growth in human lung tissue

MBio. 2013 Oct 8;4(5). pii: e00601-13. doi: 10.1128/mBio.00601-13.

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Emerging Human Middle East Respiratory Syndrome Coronavirus Causes Widespread Infection and Alveolar Damage in Human Lungs.

Am J Respir Crit Care Med. 2013 Oct 1;188(7):882-886.

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Am J Physiol Lung Cell Mol Physiol 2013, 305: 786-94

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Hackstein H, Kranz S, Lippitsch A, Wachtendorf A, Kershaw O, Gruber AD, Michel G, Lohmeyer J, Bein G, Baal N, Herold S.

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Resp Res 2013 Sept 17;14(1):91 [Epub ahead of print].

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Am J Physiol Lung Cell Mol Physiol. 13 Sept 2013, DOI: 10.1152/ajplung.00232.2013

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Bayat B, Tjahjono Y, Sydykov A, Werth S, Hippenstiel S, Weissmann N, Sachs UJ, Santoso S.

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Arterioscler Thromb Vasc Biol. 2013 Sep 12. [Epub ahead of print]

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Effects of dimethylarginine dimethylaminohydrolase-1 overexpression on the response of the pulmonary vasculature to hypoxia

Am J Respir Cell Mol Biol. 2013 Sep;49(3):491-500

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Eur Respir J. 2013 Feb;41(2):384-91. Epub 2012 May 31

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Delivery of the endolysin Cpl-1 by inhalation rescues mice with fatal pneumococcal pneumonia.

J Antimicrob Chemother. 2013 Sep;68(9):2111-7. doi: 10.1093/jac/dkt131. Epub 2013 Apr 30.

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J Infect Dis. 2013 Feb 15;207(4):693-5. doi: 10.1093/infdis/jis740. Epub 2012 Nov 29.

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Macrophage-expressed IFN-ß contributes to apoptotic alveolar epithelial cell injury in severe influenza virus pneumonia.

PLoS Pathog. 2013 Feb;9(2), Epub 2013 Feb 28

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Dis Model Mech. 2012 Nov;5(6):718-25.

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Tissue Antigens. 2012 Oct;80(4):336-40. Epub 2012 Jul 9. PMID:22776008

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Intensive Care Med. 2012 Oct;38(10):1632-9. Epub 2012 Jul 27.

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J Clin Invest 2012, Oct 1;122(10):3652-64

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Influenza a viruses target type II pneumocytes in the human lung

J Infect Dis. 2012 Dec 1;206(11):1685-94. Epub 2012 Jul 24

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Curr Pharm Des. 2012 July;18(22):3236-40. Review. PMID:22621272

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Lepper PM, Ott S, Nüesch E, von Eynatten M, Schumann C, Pletz MW, Mealing NM, Welte T, Bauer TT, Suttorp N, Jüni P, Bals R, Rohde G; German Community Acquired Pneumonia Competence Network.

Serum glucose levels for predicting death in patients admitted to hospital for community acquired pneumonia: prospective cohort study.

BMJ. 2012 May 28;344:e3397.

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Intermedin stabilized endothelial barrier function and attenuated ventilator-induced lung injury in mice.

PLoS One. 2012;7(5):e35832. Epub 2012 May 1.

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J Neurosci Methods. 2012;206(1):7-14.

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Kolditz M, Höffken G, Martus P, Rohde G, Schütte H, Bals R, Suttorp N, Pletz MW; CAPNETZ study group.

Serum cortisol predicts death and critical disease independently of CRB-65 score in community-acquired pneumonia: a prospective observational cohort study.

BMC Infect Dis. 2012 Apr 13;12:90.

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Szymanski K, Toennies M, Becher A, Fatykhova D, N’Guessan PD, Gutbier B, Klauschen F, Neuschaefer-Rube F, Schneider P, Rueckert J, Neudecker J, Bauer T, Dalhoff K, Dromann D, Gruber A, Kershaw O, Temmesfeld-Wollbrück B, Suttorp N, Hippenstiel S, Hocke AC

Streptococcus pneumoniae induced regulation of cyclooxygenase-2 in human lung tissue

Eur Respir J. 2012 Dec;40(6):1458-67. Epub 2012 Mar 22

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Transfusion. 2012 Mar;52(3):613-21. Epub 2011 Aug 24. PMID:21883263

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J Biol Chem. 2011 Mar 4;286(9):7070-81. PMID: 21193407

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J Immunol. 2012 Mar 1;188(5):2419-26. Epub 2012 Jan 20. PMID: 22266279

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Scharf S, Zahlten J, Szymanski K, Hippenstiel S, Suttorp N, N´Guessan PD.

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Exp Lung Res. 2012 Mar;38(2):100-10. doi: 10.3109/01902148.2011.652802.

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Herold S, Ludwig S, Pleschka S, Wolff T

Apoptosis signaling in influenza virus propagation, innate host defence and lung injury

J Leukoc Biol. 2012 Jul;92(1):75-82. Epub 2012 Feb 17

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Cell Microbiol. 2012 Apr;14(4):460-6. doi: 10.1111/j.1462-5822.2011.01746.x. Epub 2012 Feb 8

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Eitel J, Meixenberger K, van Laak C, Orlovski C, Hocke A, Schmeck B, Hippenstiel S, N’Guessan PD, Suttorp N, Opitz B

Rac1 regulates the NLRP3 inflammasome which mediates IL-1beta production in Chlamydophila pneumoniae infected human mononuclear cells.

PLoS One. 2012;7(1):e30379. doi: 10.1371/journal.pone.0030379. Epub 2012 Jan 20.

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Koppe U, Högner K, Witzenrath M, Bauer S, Hammerschmidt S, Suttorp N, Herold S, Opitz B.

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J Immunol. 2012 Jan 15;188(2):811-7

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N Engl J Med. 2011 Dec 1;365(22):2134-6.

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Curr Opin Hematol. 2011 Nov;18(6):436-42. Review. PMID:21912251

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Immecke SN, Baal N, Wilhelm J, Bechtel J, Knoche A, Bein G, Hackstein H

The cyclophilin-binding agent sanglifehrin A is a dendritic cell chemokine and migration inhibitor

PlosOne 2011 Mar 31;6(3):e18406

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Lippmann J, Müller H, Naujoks J, Tabeling C, Shin S, Witzenrath M, Hellwig K, Kirschning CJ, Taylor GA, Barchet W, Bauer S, Suttorp N, Roy CR, Opitz B

Dissection of a type I interferon pathway in controlling bacterial intracellular infection in mice.

Cell Microbiol. 2011 Nov;13(11):1668-82. doi: 10.1111/j.1462-5822.2011.01646.x. Epub 2011 Aug 24

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Hackstein H, Knoche A, Nockher A, Jurk M, Vollmer J, Bein G

The TLR7/8 ligand resiquimod targets monocyte-derived dendritic cell differentiation via TLR8 and augments functional dendritic cell generation

Cell Immunol. 2011;271(2):401-12. doi: 10.1016/j.cellimm.2011.08.008. Epub 2011 Aug 22

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Müller HC, Hocke AC, Hellwig K, Gutbier B, Peters H, Schönrock SM, Tschernig T, Schmiedl A, Hippenstiel S, N´Guessan PD, Rosseau S, Suttorp N, Witzenrath M.

The Sphingosine-1 Phosphate receptor agonist FTY720 dose dependently affected endothelial integrity in vitro and aggravated ventilator-induced lung injury in mice.

Pulm Pharmacol Ther. 2011 Aug;24(4):377-85. doi: 10.1016/j.pupt.2011.01.017. Epub 2011 Mar 23.

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Eur Respir J. 2011 Jul;38(1):147-53. Epub 2010 Dec 9.

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The NLRP3 Inflammasome is Differentially Activated by Pneumolysin Variants and Contributes to Host Defense in Pneumococcal Pneumonia.

J Immunol. 2011 Jul 1;187(1):434-40. Epub 2011 Jun 6.

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Transfusion. 2011 Jun;51(6):1271-7. Epub 2010 Dec 16. PMID:21166683

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Krasteva G, Canning BJ, Hartmann P, Veres TZ, Papadakis T, Mühlfeld C, Schliecker K, Tallini YN, Braun A, Hackstein H, Baal N, Weihe E, Schütz B, Kotlikoff M, Ibanez-Tallon I, Kummer W

Cholinergic chemosensory cells in the trachea regulate breathing.

Proc Natl Acad Sci USA. 2011, 108(23): 9478-9483

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Pinto R, Herold S, Cakarova L, Hoegner K, Seeger W, Lohmeyer J, Planz O, Pleschka S

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Antiviral Res. 2011 Oct;92(1):45-56. Epub 2011 May 27

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von Baum H, Schweiger B, Welte T, Marre R, Suttorp N, Pletz MW, Ewig S; CAPNETZ Study Group.

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Eur Respir J. 2011 May;37(5):1151-7. Epub 2010 Sep 3.

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Ewig S, Hecker H, Suttorp N, Marre R, Welte T; CAPNETZ study group.

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J Infect. 2011 Mar;62(3):218-25. Epub 2011 Jan 27.

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Exudate macrophages attenuate epithelial injury by the release of IL-1 receptor antagonist in gram-negative pneumonia.

Am J Respir Crit Care Med. 2011 May 15;183(10):1380-90. doi: 10.1164/rccm.201009-1431OC. Epub 2011 Jan 28

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Eitel J, Suttorp N, Opitz B.

Innate immune recognition and inflammasome activation in Listeria monocytogenes infection.

Front Microbiol. 2011;1: 149

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Mechanism of transfusion-related acute lung injury induced by HLA class II antibodies.

Blood. 2011 Jan 13;117(2):669-77. Epub 2010 Oct 28

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Assessment of inflammatory markers in patients with community-acquired pneumonia--influence of antimicrobial pre-treatment: results from the German competence network CAPNETZ.

Clin Chim Acta. 2010 Dec 14;411(23-24):1929-34. Epub 2010 Aug 7.

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Krüger S, Ewig S, Giersdorf S, Hartmann O, Suttorp N, Welte T; German Competence Network for the Study of Community Acquired Pneumonia (CAPNETZ) Study Group.

Cardiovascular and inflammatory biomarkers to predict short- and long-term survival in community-acquired pneumonia: Results from the German Competence Network, CAPNETZ.

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Thorax. 2010 Dec;65(12):1077-84. Epub 2010 Oct 22

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Respir Res. 2010 Sep 29;11:133. doi: 10.1186/1465-9921-11-133

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Müller HC, Hellwig K, Rosseau S, Tschernig T, Schmiedl A, Gutbier B, Schmeck B, Hippenstiel S, Peters H, Morawietz L, Suttorp N, Witzenrath M.

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Crit Care. 2010 14(4):R143. Epub 2010 Jul 30.

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Eur Respir J. 2011 Mar;37(3):648-57. Epub 2010 Jul 22.

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Scharf S, Vardarova K, Lang F, Schmeck B, Opitz B, Flieger A, Heuner K, Hippenstiel S, Suttorp N, N´Guessan PD.

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Respir Res. 2010 Jul 8;11:93.

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TLR2- and nucleotide-binding oligomerization domain 2-dependent Krüppel-like factor 2 expression downregulates NF-kappa B-related gene expression.

J Immunol. 2010 Jul 1;185(1):597-604. Epub 2010 Jun 4

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Opitz B, van Laak V, Eitel J, Suttorp N.

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Am J Respir Crit Care Med. 2010 Jun 15;181(12):1294-309. Epub 2010 Feb 18.

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Mikulski Z, Zaslona Z, Cakarova L, Hartmann P, Wilhelm J, Tecott LH, Lohmeyer J, Kummer W

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Am J Physiol Lung Cell Mol Physiol. 2010, 299(2): L272-L280

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Am J Physiol Lung Cell Mol Physiol. 2010 May;298(5):L687-95. Epub 2010 Feb 12.

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Pulm Pharmacol Ther. 2010 Aug;23(4):334-44. Epub 2010 Apr 1.

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Essential role of mitochondrial antiviral signaling, IFN regulatory factor (IRF)3, and IRF7 in Chlamydophila pneumoniae-mediated IFN-beta response and control of bacterial replication in human endothelial cells.

J Immunol. 2010 Mar 15;184(6):3072-8. Epub 2010 Feb 12.

www.ncbi.nlm.nih.gov/pubmed/20154210

Krüger S, Ewig S, Kunde J, Hartmann O, Suttorp N, Welte T; CAPNETZ Study Group.

Pro-atrial natriuretic peptide and pro-vasopressin for predicting short-term and long-term survival in community-acquired pneumonia: results from the German Competence Network CAPNETZ.

Thorax. 2010 Mar;65(3):208-14.

www.ncbi.nlm.nih.gov/pubmed/20335288

von Baum H, Welte T, Marre R, Suttorp N, Ewig S; CAPNETZ study group.

Community-acquired pneumonia through Enterobacteriaceae and Pseudomonas aeruginosa: Diagnosis, incidence and predictors.

Eur Respir J. 2010 Mar;35(3):598-605. Epub 2009 Aug 13.

www.ncbi.nlm.nih.gov/pubmed/19679601

Singer BB, Scheffrahn I, Kammerer R, Suttorp N, Ergun S, Slevogt H.

Deregulation of the CEACAM expression pattern causes undifferentiated cell growth in human lung adenocarcinoma cells.

PLoS One. 2010 Jan 18;5(1):e8747.

www.ncbi.nlm.nih.gov/pubmed/20090913

Meixenberger K, Pache F, Eitel J, Schmeck B, Hippenstiel S, Slevogt H, N´Guessan P, Witzenrath M, Netea MG, Chakraborty T, Suttorp N, Opitz B.

Listeria monocytogenes-infected human peripheral blood mononuclear cells produce IL-1beta,depending on listeriolysin O and NLRP3.

J Immunol. 2010 Jan 15;184(2):922-30. Epub 2009 Dec 11.

www.ncbi.nlm.nih.gov/pubmed/20008285