Transregio SFB-TR 84 “Innate Immunity of the Lung: Mechanisms of Pathogen Attack and Host Defence in Pneumonia“

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Publications

Krischuns T, Arragain B, Isel C, Paisant S, Budt M, Wolff T, Cusack S, Naffakh N.

The host RNA polymerase II C-terminal domain is the anchor for replication of the influenza virus genome

Nat Commun. 2024 Feb 5;15(1):1064. https://pubmed.ncbi.nlm.nih.gov/38316757/ 

Antelmann H

Redox signaling mechanisms during host-pathogen interactions in the human pathogen Staphylococcus aureus - Chapter 12

In: Molecular Medical Microbiology (Third Edition) 2024, Pages 217-256, Academic Press. https://www.sciencedirect.com/science/article/pii/B9780128186190000514

Pervizaj-Oruqaj L, Selvakumar B, Ferrero MR, Heiner M, Malainou C, Glaser RD, Wilhelm J, Bartkuhn M, Weiss A, Alexopoulos I, Witte B, Gattenlöhner S, Vadász I, Morty RE, Seeger W, Schermuly RT, Vazquez-Armendariz AI, Herold S.

Alveolar macrophage-expressed Plet1 is a driver of lung epithelial repair after viral pneumonia

Nat Commun. 2024 Jan 2;15(1):87. https://pubmed.ncbi.nlm.nih.gov/38167746/

Loi VV, Busche T, Kuropka B, Müller S, Methling K, Lalk M, Kalinowski J, Antelmann H.

Staphylococcus aureus adapts to the immunometabolite itaconic acid by inducing acid and oxidative stress responses including S-bacillithiolations and S-itaconations.

Free Radic Biol Med. 2023 Nov 1;208:859-876. https://pubmed.ncbi.nlm.nih.gov/37793500/ 

Malainou C, Abdin SM, Lachmann N, Matt U, Herold S.

Alveolar macrophages in tissue homeostasis, inflammation, and infection: evolving concepts of therapeutic targeting

J Clin Invest. 2023 Oct 2;133(19):e170501. doi: 10.1172/JCI170501. https://pubmed.ncbi.nlm.nih.gov/37781922/

Alberro-Brage A, Kryvenko V, Malainou C, Günther S, Morty RE, Seeger W, Herold S, Samakovlis C, Vadász I

Influenza virus decreases albumin uptake and megalin expression in alveolar epithelial cells

Front Immunol 2023 Sep, 1:14:1260973. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10505651/ 

Jung AL, Han M, Griss K, Bertrams W, Nell C, Greulich T, Klemmer A, Pott H, Heider D, Vogelmeier CF, Hippenstiel S, Suttorp N, Schmeck B.

Novel protein biomarkers for pneumonia and acute exacerbations in COPD: a pilot study.

Front Med (Lausanne). 2023 Jun 5;10:1180746. doi: 10.3389/fmed.2023.1180746. eCollection 2023. https://pubmed.ncbi.nlm.nih.gov/37342494/

Parshad B, Schlecht MN, Baumgardt M, Ludwig K, Nie C, Rimondi A, Hönzke K, Angioletti-Uberti S, Khatri V, Schneider P, Herrmann A, Haag R, Hocke AC, Wolff T, Bhatia S.

Dual-Action Heteromultivalent Glycopolymers Stringently Block and Arrest Influenza A Virus Infection In Vitro and Ex Vivo

Nano Lett 2023 Jun 14;23(11):4844-4853. https://pubmed.ncbi.nlm.nih.gov/37220024/

Fritsch VN, Loi VV, Kuropka B, Gruhlke M, Weise C, Antelmann H.

The MarR/DUF24-Family QsrR Repressor Senses Quinones and Oxidants by Thiol Switch Mechanisms in Staphylococcus aureus.

Antioxid Redox Signal. 2023 May;38(13-15):877-895. https://pubmed.ncbi.nlm.nih.gov/36242097/

Goekeri C, Pennitz P, Groenewald W, Behrendt U, Kirsten H, Zobel CM, Berger S, Heinz GA, Mashreghi MF, Wienhold SM, Dietert K, Dorhoi A, Gruber AD, Scholz M, Rohde G, Suttorp N, Capnetz Study Group, Witzenrath M, Nouailles G.

MicroRNA-223 Dampens Pulmonary Inflammation during Pneumococcal Pneumonia.

Cells. 2023 Mar 21;12(6):959. doi: 10.3390/cells12060959.PMID: 36980300 https://pubmed.ncbi.nlm.nih.gov/36980300/

Shearer HL, Loi VV, Weiland P, Bange G, Altegoer F, Hampton MB, Antelmann H, Dickerhof N.

MerA functions as a hypothiocyanous acid reductase and defense mechanism in Staphylococcus aureus.

Mol Microbiol. 2023 Apr;119(4):456-470. https://pubmed.ncbi.nlm.nih.gov/36779383/​​​​​​​ 

Fritsch VN, Linzner N, Busche T, Said N, Weise C, Kalinowski J, Wahl MC, Antelmann H.

The MerR-family regulator NmlR is involved in the defense against oxidative stress in Streptococcus pneumoniae.

Mol Microbiol. 2023 Feb;119(2):191-207. https://pubmed.ncbi.nlm.nih.gov/36349475/

Loi VV, Busche T, Schnaufer F, Kalinowski J, Antelmann H.

The neutrophil oxidant hypothiocyanous acid causes a thiol-specific stress response and an oxidative shift of the bacillithiol redox potential in Staphylococcus aureus.

Microbiol Spectr. 2023 Dec 12;11(6):e0325223. https://pubmed.ncbi.nlm.nih.gov/37930020/

Erfinanda L, Zou L, Gutbier B, Kneller L, Weidenfeld S, Michalick L, Lei D, Reppe K, Teixeira Alves LG, Schneider B, Zhang Q, Li C, Fatykhova D, Schneider P, Liedtke W, Sohara E, Mitchell TJ, Gruber AD, Hocke A, Hippenstiel S, Suttorp N, Olschewski A, Mall MA, Witzenrath M, Kuebler WM

Loss of endothelial CFTR drives barrier failure and edema formation in lung infection and can be targeted by CFTR potentiation

Sci Transl Med. 2022 Dec 7;14(674):eabg8577.
doi: 10.1126/scitranslmed.abg8577. https://pubmed.ncbi.nlm.nih.gov/36475904/

Jones MR, Lingampally A, Ahmadvand N, Chong L, Wu J, Wilhem J, Vazquez-Armendariz AI, Ansari M, Herold S, Ornitz DM, Schiller HB, Chao CM, Zhang JS, Carraro G, Bellusci S.

FGFR2b signalling restricts lineage-flexible alveolar progenitors during mouse lung development and converges in mature alveolar type 2 cells.

Cell Mol Life Sci. 2022 Nov 29;79(12):609. doi: 10.1007/s00018-022-04626-2.
https://pubmed.ncbi.nlm.nih.gov/36445537/

Banovic F, Schulze S, Abu Mraheil M, Hain T, Chakraborty T, Orian-Rousseau V, Moroniak S, Weiss C, Ishikawa H, Schroten H, Adam R, Schwerk C.

Different Involvement of Vimentin during Invasion by Listeria monocytogenes at the Blood-Brain and the Blood-Cerebrospinal Fluid Barriers In Vitro

Int J Mol Sci 2022 Oct 26;23(21):12908. 
doi: 10.3390/ijms232112908. https://pubmed.ncbi.nlm.nih.gov/36361697/

Hönzke K, Obermayer B, Mache C, Fathykova D, Kessler M, Dökel S, Wyler E, Baumgardt M, Löwa A, Hoffmann K, Graff P, Schulze J, Mieth M, Hellwig K, Demir Z, Biere B, Brunotte L, Mecate-Zambrano A, Bushe J, Dohmen M, Hinze C, Elezkurtaj S, Tönnies M, Bauer TT, Eggeling S, Tran HL, Schneider P, Neudecker J, Rückert JC, Schmidt-Ott KM, Busch J, Klauschen F, Horst D, Radbruch H, Radke J, Heppner F, Corman VM, Niemeyer D, Müller MA, Goffinet C, Mothes R, Pascual-Reguant A, Hauser AE, Beule D, Landthaler M, Ludwig S, Suttorp N, Witzenrath M, Gruber AD, Drosten C, Sander LE, Wolff T, Hippenstiel S, Hocke AC

Human lungs show limited permissiveness for SARS-CoV-2 due to scarce ACE2 levels but virus-induced expansion of inflammatory macrophages

Eur Respir J. 2022 Dec 1;60(6):2102725. doi: 10.1183/13993003.02725-2021. 
https://pubmed.ncbi.nlm.nih.gov/35728978/

Bertrams W, Hönzke K, Obermayer B, Tönnies M, Bauer TT, Schneider P, Neudecker J, Rückert JC, Stiewe T, Nist A, Eggeling S, Suttorp N, Wolff T, Hippenstiel S, Schmeck B, Hocke AC

Transcriptomic comparison of primary human lung cells with lung tissue samples and the human A549 lung cell line highlights cell type specific responses during infections with influenza A virus

Sci Rep 12, 2022 Nov 29;12(1):20608.
doi 10.1038/s41598-022-24792-4. https://pubmed.ncbi.nlm.nih.gov/36446841/

Niemeyer D, Stenzel S, Veith T, Schroeder S, Friedmann K, Weege F, Trimpert J, Heinze J, Richter A, Jansen J, Emanuel J, Kazmierski J, Pott F, Jeworowski LM, Olmer R, Jaboreck MC, Tenner B, Papies J, Walper F, Schmidt ML, Heinemann N, Möncke-Buchner E, Baumgardt M, Hoffmann K, Widera M, Thao TTN, Balázs A, Schulze J, Mache C, Jones TC, Morkel M, Ciesek S, Hanitsch LG, Mall MA, Hocke AC, Thiel V, Osterrieder K, Wolff T, Martin U, Corman VM, Müller MA, Goffinet C, Drosten C.

SARS-CoV-2 variant Alpha has a spike-dependent replication advantage over the ancestral B.1 strain in human cells with low ACE2 expression

PLoS Biol. 2022 Nov 16;20(11):e3001871. https://pubmed.ncbi.nlm.nih.gov/36383605/

Wagner C, Balazs A, Schatterny J, Zhou-Suckow Z, Duerr J, Schultz C, Mall MA.

Genetic Deletion of Mmp9 Does Not Reduce Airway Inflammation and Structural Lung Damage in Mice with Cystic Fibrosis-like Lung Disease.

Int J Mol Sci. 2022 Nov 2;23(21):13405. doi: 10.3390/ijms232113405. https://pubmed.ncbi.nlm.nih.gov/36362203/

Kimmig LM, Rako ZA, Ziegler S, Richter MJ, G S AT, Roller F, Grimminger F, Vadász I, Seeger W, Herold S, Tello K, Matt U.

Long-term comprehensive cardiopulmonary phenotyping of COVID-19.

Respir Res. 2022 Sep 21;23(1):263. doi: 10.1186/s12931-022-02173-9. https://pubmed.ncbi.nlm.nih.gov/36131349/

Martin TR, Zemans RL, Ware LB, Schmidt EP, Riches DWH, Bastarache L, Calfee CS, Desai TJ, Herold S, Hough CL, Looney MR, Matthay MA, Meyer N, Parikh SM, Stevens T, Thompson BT.

New Insights into Clinical and Mechanistic Heterogeneity of the Acute Respiratory Distress Syndrome: Summary of the Aspen Lung Conference 2021.

Am J Respir Cell Mol Biol. 2022 Sep;67(3):284-308. doi: 10.1165/rcmb.2022-0089WS. 
https://pubmed.ncbi.nlm.nih.gov/35679511/

Hoffmann K, Obermayer B, Hönzke K, Fatykhova D, Demir Z, Löwa A, Alves LGT, Wyler E, Lopez-Rodriguez E, Mieth M, Baumgardt M, Hoppe J, Firsching TC, Tönnies M, Bauer TT, Eggeling S, Tran HL, Schneider P, Neudecker J, Rückert JC, Gruber AD, Ochs M, Landthaler M, Beule D, Suttorp N, Hippenstiel S, Hocke AC, Kessler M.

Human alveolar progenitors generate dual lineage bronchioalveolar organoids

Commun Biol. 2022 Aug 25;5(1):875. doi: 10.1038/s42003-022-03828-5. https://pubmed.ncbi.nlm.nih.gov/36008580/

Hülsemann M, Wiebach J, Drude NI, Kniffert S, Behm L, Hönzke K, Baumgardt M, Hippenstiel S, Hocke AC, Dirnagl U, Tölch U.

Introducing quality measures in an academic research consortium: Lessons and recommendation from implementing an ad hoc quality management system for organ model research

EMBO Rep. 2022 Aug 3;23(8):e55095. doi: 10.15252/embr.202255095. Epub 2022 Jul 25. https://pubmed.ncbi.nlm.nih.gov/35876564/

Pennitz P, Kirsten H, Friedrich VD, Wyler E, Goekeri C, Obermayer B, Heinz GA, Mashreghi MF, Büttner M, Trimpert J, Landthaler M, Suttorp N, Hocke AC, Hippenstiel S, Tönnies M, Scholz M, Kuebler WM, Witzenrath M, Hoenzke K, Nouailles G.

A pulmonologist's guide to perform and analyse cross-species single lung cell transcriptomics

Eur Respir Rev. 2022 Jul 27;31(165):220056. doi: 10.1183/16000617.0056-2022. https://pubmed.ncbi.nlm.nih.gov/35896273/

Kheirollahi V, Khadim A, Kiliaris G, Korfei M, Barroso MM, Alexopoulos I, Vazquez-Armendariz AI, Wygrecka M, Ruppert C, Guenther A, Seeger W, Herold S, El Agha E.

Transcriptional Profiling of Insulin-like Growth Factor Signaling Components in Embryonic Lung Development and Idiopathic Pulmonary Fibrosis.

Cells. 2022 Jun 20;11(12):1973. doi: 10.3390/cells11121973. https://pubmed.ncbi.nlm.nih.gov/35741102/​​​​​​​

Margaroli C, Horati H, Garratt LW, Giacalone VD, Schofield C, Dittrich AS, Rosenow T, Dobosh BS, Lim HS, Frey DL, Veltman M, Silva GL, Brown MR, Schultz C, Tiddens HAWM, Ranganathan S, Chandler JD, Qiu P, Peng L, Scholte BJ, Mall MA, Kicic A, Guglani L, Stick SM, Janssens HM, Tirouvanziam R.

Macrophage PD-1 associates with neutrophilia and reduced bacterial killing in early cystic fibrosis airway disease

J Cyst Fibros. 2022 Jun 19;S1569-1993(22)00588-4. doi: 10.1016/j.jcf.2022.06.001. https://pubmed.ncbi.nlm.nih.gov/35732550/

Taghizadeh S, Chao CM, Guenther S, Glaser L, Gersmann L, Michel G, Kraut S, Goth K, Koepke J, Heiner M, Vazquez-Armendariz AI, Herold S, Samakovlis C, Weissmann N, Ricci F, Aquila G, Boyer L, Ehrhardt H, Minoo P, Bellusci S, Rivetti S.

FGF10 Triggers De Novo Alveologenesis in a Bronchopulmonary Dysplasia Model: Impact on Resident Mesenchymal Niche Cells.

Stem Cells. 2022 Jun 22;40(6):605-617. doi:10.1093/stmcls/sxac025. https://pubmed.ncbi.nlm.nih.gov/35437594/

Ahmadvand N, Lingampally A, Khosravi F, Vazquez-Armendariz AI, Rivetti S, Jones MR, Wilhelm J, Herold S, Barreto G, Koepke J, Samakovlis C, Carraro G, Zhang JS, Al Alam D, Bellusci S.

Fgfr2b signaling is essential for the maintenance of the alveolar epithelial type 2 lineage during lung homeostasis in mice.

Cell Mol Life Sci. 2022 May 19;79(6):302. doi: 10.1007/s00018-022-04327-w. https://pubmed.ncbi.nlm.nih.gov/35587837/

Frey DL, Bridson C, Dittrich S, Graeber SY, Stahl M, Wege S, Herth F, Sommerburg O, Schultz C, Dalpke A, Mall MA, Boutin S.

Changes in Microbiome Dominance Are Associated With Declining Lung Function and Fluctuating Inflammation in People With Cystic Fibrosis

Front Microbiol. 2022 May 13;13:885822. doi: 10.3389/fmicb.2022.885822. eCollection 2022. https://pubmed.ncbi.nlm.nih.gov/35633718/

Patrono LV, Vrancken B, Budt M, Düx A, Lequime S, Boral S, Gilbert MTP, Gogarten JF, Hoffmann L, Horst D, Merkel K, Morens D, Prepoint B, Schlotterbeck J, Schuenemann VJ, Suchard MA, Taubenberger JK, Tenkhoff L, Urban C, Widulin N, Winter E, Worobey M, Schnalke T, Wolff T, Lemey P, Calvignac-Spencer S.

Archival influenza virus genomes from Europe reveal genomic variability during the 1918 pandemic

Nat Commun. 2022 May 10;13(1):2314. doi: 10.1038/s41467-022-29614-9. https://pubmed.ncbi.nlm.nih.gov/35538057/

Vazquez-Armendariz AI, Barroso MM, El Agha E, Herold S.

3D In Vitro Models: Novel Insights into Idiopathic Pulmonary Fibrosis Pathophysiology and Drug Screening.

Cells. 2022 May 2;11(9):1526. doi: 10.3390/cells11091526. 
https://pubmed.ncbi.nlm.nih.gov/35563831/

Loske J, Röhmel J, Lukassen S, Stricker S, Magalhães VG, Liebig J, Chua RL, Thürmann L, Messingschlager M, Seegebarth A, Timmermann B, Klages S, Ralser M, Sawitzki B, Sander LE, Corman VM, Conrad C, Laudi S, Binder M, Trump S, Eils R, Mall MA, Lehmann I.

Pre-activated antiviral innate immunity in the upper airways controls early SARS-CoV-2 infection in children

Nat Biotechnol. 2022 Mar;40(3):319-324. doi: 10.1038/s41587-021-01037-9. Epub 2021 Aug 18.  https://pubmed.ncbi.nlm.nih.gov/34408314/

Zhu L, Duerr J, Zhou-Suckow Z, Wagner W, Weinheimer O, Salomon J, Leitz D, Konietzke P, Yu H, Ackermann M, Stiller W, Kauczor HU, Mall MA, Wielpütz MO.

µCT to quantify muco-obstructive lung disease and effects of neutrophil elastase knockout in mice

Am J Physiol Lung Cell Mol Physiol. 2022 Mar 1;322(3):L401-L411. doi: 10.1152/ajplung.00341.2021. Epub 2022 Jan 26. https://pubmed.ncbi.nlm.nih.gov/35080183/

Sauerhering L, Kuznetsova I, Kupke A, Meier L, Halwe S, Rohde C, Schmidt J, Morty RE, Danov O, Braun A, Vadász I, Becker S, Herold S.

Cyclosporin A Reveals Potent Antiviral Effects in Preclinical Models of SARS-CoV-2 Infection

Am J Respir Crit Care Med. 2022 Feb 15. doi: 10.1164/rccm.202108-1830LE. Online ahead of print. https://pubmed.ncbi.nlm.nih.gov/35167409/

Conrad C, Yildiz D, Cleary SJ, Margraf A, Cook L, Schlomann U, Panaretou B, Bowser JL, Karmouty-Quintana H, Li J, Berg NK, Martin SC, Aljohmani A, Moussavi-Harami SF, Wang KM, Tian JJ, Magnen M, Valet C, Qiu L, Singer JP, Eltzschig HK; CAPSys Study Group, Bertrams W, Herold S, Suttorp N, Schmeck B, Ball ZT, Zarbock A, Looney MR, Bartsch JW.

ADAM8 signaling drives neutrophil migration and ARDS severity

JCI Insight. 2022 Feb 8;7(3):e149870. doi: 10.1172/jci.insight.149870.  https://pubmed.ncbi.nlm.nih.gov/35132956/

Georg P, Astaburuaga-García R, Bonaguro L, Brumhard S, Michalick L, Lippert LJ, Kostevc T, Gäbel C, Schneider M, Streitz M, Demichev V, Gemünd I, Barone M, Tober-Lau P, Helbig ET, Hillus D, Petrov L, Stein J, Dey HP, Paclik D, Iwert C, Mülleder M, Aulakh SK, Djudjaj S, Bülow RD, Mei HE, Schulz AR, Thiel A, Hippenstiel S, Saliba AE, Eils R, Lehmann I, Mall MA, Stricker S, Röhmel J, Corman VM, Beule D, Wyler E, Landthaler M, Obermayer B, von Stillfried S, Boor P, Demir M, Wesselmann H, Suttorp N, Uhrig A, Müller-Redetzky H, Nattermann J, Kuebler WM, Meisel C, Ralser M, Schultze JL, Aschenbrenner AC, Thibeault C, Kurth F, Sander LE, Blüthgen N, Sawitzki B; PA-COVID-19 Study Group.

Complement activation induces excessive T cell cytotoxicity in severe COVID-19

Cell. 2022 Feb 3;185(3):493-512.e25.  doi: 10.1016/j.cell.2021.12.040.  Epub 2021 Dec 28. pubmed.ncbi.nlm.nih.gov/35032429/

Demichev V, Tober-Lau P, Nazarenko T, Lemke O, Kaur Aulakh S, Whitwell HJ, Röhl A, Freiwald A, Mittermaier M, Szyrwiel L, Ludwig D, Correia-Melo C, Lippert LJ, Helbig ET, Stubbemann P, Olk N, Thibeault C, Grüning NM, Blyuss O, Vernardis S, White M, Messner CB, Joannidis M, Sonnweber T, Klein SJ, Pizzini A, Wohlfarter Y, Sahanic S, Hilbe R, Schaefer B, Wagner S, Machleidt F, Garcia C, Ruwwe-Glösenkamp C, Lingscheid T, Bosquillon de Jarcy L, Stegemann MS, Pfeiffer M, Jürgens L, Denker S, Zickler D, Spies C, Edel A, Müller NB, Enghard P, Zelezniak A, Bellmann-Weiler R, Weiss G, Campbell A, Hayward C, Porteous DJ, Marioni RE, Uhrig A, Zoller H, Löffler-Ragg J, Keller MA, Tancevski I, Timms JF, Zaikin A, Hippenstiel S, Ramharter M, Müller-Redetzky H, Witzenrath M, Suttorp N, Lilley K, Mülleder M, Sander LE; PA-COVID-19 Study group; Kurth F, Ralser M.

A proteomic survival predictor for COVID-19 patients in intensive care.

PLOS Digit Health. 2022 Jan 18;1(1):e0000007. doi: 10.1371/journal.pdig.0000007. https://pubmed.ncbi.nlm.nih.gov/36812516/

Wienhold SM, Brack MC, Nouailles G, Krishnamoorthy G, Korf IHE, Seitz C, Wienecke S, Dietert K, Gurtner C, Kershaw O, Gruber AD, Ross A, Ziehr H, Rohde M, Neudecker J, Lienau J, Suttorp N, Hippenstiel S, Hocke AC, Rohde C, Witzenrath M.

Preclinical Assessment of Bacteriophage Therapy against Experimental Acinetobacter baumannii Lung Infection.

Viruses. 2021 Dec 24;14(1):33. https://pubmed.ncbi.nlm.nih.gov/35062236/

Metzger MI, Graeber SY, Stahl M, Sommerburg O, Mall MA, Dalpke AH, Boutin S.

A Volatile and Dynamic Longitudinal Microbiome Is Associated With Less Reduction in Lung Function in Adolescents With Cystic Fibrosis

Front Cell Infect Microbiol. 2021 Dec 6;11:763121. doi: 10.3389/fcimb.2021.763121. eCollection 2021. https://pubmed.ncbi.nlm.nih.gov/34938669/

Wendisch D, Dietrich O, Mari T, von Stillfried S, Ibarra IL, Mittermaier M, Mache C, Chua RL, Knoll R, Timm S, Brumhard S, Krammer T, Zauber H, Hiller AL, Pascual-Reguant A, Mothes R, Bülow RD, Schulze J, Leipold AM, Djudjaj S, Erhard F, Geffers R, Pott F, Kazmierski J, Radke J, Pergantis P, Baßler K, Conrad C, Aschenbrenner AC, Sawitzki B, Landthaler M, Wyler E, Horst D; Deutsche COVID-19 OMICS Initiative (DeCOI), Hippenstiel S, Hocke A, Heppner FL, Uhrig A, Garcia C, Machleidt F, Herold S, Elezkurtaj S, Thibeault C, Witzenrath M, Cochain C, Suttorp N, Drosten C, Goffinet C, Kurth F, Schultze JL, Radbruch H, Ochs M, Eils R, Müller-Redetzky H, Hauser AE, Luecken MD, Theis FJ, Conrad C, Wolff T, Boor P, Selbach M, Saliba AE, Sander LE.

SARS-CoV-2 infection triggers profibrotic macrophage responses and lung fibrosis.

Cell. 2021 Nov 27:S0092-8674(21)01383-0. doi: 10.1016/j.cell.2021.11.033. Epub ahead of print. PMID: 34914922. pubmed.ncbi.nlm.nih.gov/34914922/

Mahmoud W, Perniss A, Poharkar K, Soultanova A, Pfeil U, Hoek A, Bhushan S, Hain T, Gärtner U, Kummer W.

CXCL13 is expressed in a subpopulation of neuroendocrine cells in the murine trachea and lung.

Cell Tissue Res. 2022 Oct;390(1):35-49. doi: 10.1007/s00441-021-03552-2. pubmed.ncbi.nlm.nih.gov/34762185/

Hey J, Paulsen M, Toth R, Weichenhan D, Butz S, Schatterny J, Liebers R, Lutsik P, Plass C, Mall MA.

Epigenetic reprogramming of airway macrophages promotes polarization and inflammation in muco-obstructive lung disease

Nat Commun. 2021 Nov 11;12(1):6520.  doi: 10.1038/s41467-021-26777-9. pubmed.ncbi.nlm.nih.gov/34764283/

Mösbauer K, Fritsch VN, Adrian L, Bernhardt J, Gruhlke MCH, Slusarenko AJ, Niemeyer D, Antelmann H.

The Effect of Allicin on the Proteome of SARS-CoV-2 Infected Calu-3 Cells.

Front Microbiol. 2021 Oct 28;12:746795. doi: 10.3389/fmicb.2021.746795. PMID: 34777295; PMCID: PMC8581659. pubmed.ncbi.nlm.nih.gov/34777295/

Witkowski M, Tizian C, Ferreira-Gomes M, Niemeyer D, Jones TC, Heinrich F, Frischbutter S, Angermair S, Hohnstein T, Mattiola I, Nawrath P, Mc Ewen S, Zocche S, Viviano E, Heinz GA, Maurer M, Kölsch U, Chua RL, Aschman T, Meisel C, Radke J, Sawitzki B, Roehmel J, Allers K, Moos V, Schneider T, Hanitsch L, Mall MA, Conrad C, Radbruch H, Duerr CU, Trapani JA, Marcenaro E, Kallinich T, Corman VM, Kurth F, Sander LE, Drosten C, Treskatsch S, Durek P, Kruglov A, Radbruch A, Mashreghi MF, Diefenbach A.

Untimely TGFβ responses in COVID-19 limit antiviral functions of NK cells

Nature. 2021 Oct 25. doi: 10.1038/s41586-021-04142-6. Epub ahead of print. PMID: 34695836. pubmed.ncbi.nlm.nih.gov/34695836/

Van Loi V, Busche T, Fritsch VN, Weise C, Gruhlke MCH, Slusarenko AJ, Kalinowski J, Antelmann H.

The two-Cys-type TetR repressor GbaA confers resistance under disulfide and electrophile stress in Staphylococcus aureus.

Free Radic Biol Med. 2021 Oct 19;177:120-131. doi: 10.1016/j.freeradbiomed.2021.10.024. Epub ahead of print. PMID: 34678418. pubmed.ncbi.nlm.nih.gov/34678418/

Schulze J, Mache C, Balázs A, Frey D, Niemeyer D, Olze H, Dommerich S, Drosten C, Hocke AC, Mall MA, Hippenstiel S, Wolff T.

Analysis of SARS-CoV-2 replication in explant cultures of the human upper respiratory tract reveals broad tissue tropism of wild-type and B.1.1.7 variant viruses.

J Infect Dis. 2021 Oct 15:jiab523. doi: 10.1093/infdis/jiab523. Epub ahead of print. PMID: 34651643; PMCID: PMC8524635. pubmed.ncbi.nlm.nih.gov/34651643/

Shaban MS, Müller C, Mayr-Buro C, Weiser H, Meier-Soelch J, Albert BV, Weber A, Linne U, Hain T, Babayev I, Karl N, Hofmann N, Becker S, Herold S, Schmitz ML, Ziebuhr J, Kracht M.

Multi-level inhibition of coronavirus replication by chemical ER stress.

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Front Immunol. 2021 Sep 13;12:726135. doi: 10.3389/fimmu.2021.726135. PMID: 34589087; PMCID: PMC8473698. pubmed.ncbi.nlm.nih.gov/34589087/

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Nat Commun. 2021 Sep 7;12(1):5324. doi: 10.1038/s41467-021-25519-1. PMID: 34493730. pubmed.ncbi.nlm.nih.gov/34493730/

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Science. 2021 Aug 31:eabh1823. doi: 10.1126/science.abh1823. Epub ahead of print. PMID: 34465633. pubmed.ncbi.nlm.nih.gov/34465633/

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The Antimicrobial Activity of the AGXX® Surface Coating Requires a Small Particle Size to Efficiently Kill Staphylococcus aureus.

Front Microbiol. 2021 Aug 12;12:731564. doi: 10.3389/fmicb.2021.731564. PMID: 34456898; PMCID: PMC8387631. pubmed.ncbi.nlm.nih.gov/34456898/

Engelmann TA, Knudsen L, Leitz DHW, Duerr J, Beers MF, Mall MA, Ochs M.

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Int J Mol Sci. 2021 Jul 16;22(14):7607. doi: 10.3390/ijms22147607. PMID: 34299227; PMCID: PMC8306112. pubmed.ncbi.nlm.nih.gov/34299227/

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Cell Microbiol. 2021 Jun;23(6):e13322. doi: 10.1111/cmi.13322. Epub 2021 Mar 9. https://pubmed.ncbi.nlm.nih.gov/33629465/

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A time-resolved proteomic and prognostic map of COVID-19

Cell Syst. 2021 Jun 14:S2405-4712(21)00160-5. doi: 10.1016/j.cels.2021.05.005. Epub ahead of print. PMID: 34139154; PMCID: PMC8201874. pubmed.ncbi.nlm.nih.gov/34139154/

Vazquez-Armendariz AI, Seeger W, Herold S, El Agha E.

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STAR Protoc. 2021 Jun 11;2(2):100594. doi: 10.1016/j.xpro.2021.100594. PMID: 34169288; PMCID: PMC8209683. pubmed.ncbi.nlm.nih.gov/34169288/

Leitz DHW, Duerr J, Mulugeta S, Seyhan Agircan A, Zimmermann S, Kawabe H, Dalpke AH, Beers MF, Mall MA.

Congenital Deletion of Nedd4-2 in Lung Epithelial Cells Causes Progressive Alveolitis and Pulmonary Fibrosis in Neonatal Mice.

Int J Mol Sci. 2021 Jun 7;22(11):6146. doi: 10.3390/ijms22116146. PMID: 34200296; PMCID: PMC8201155. pubmed.ncbi.nlm.nih.gov/34200296/

Hagner M, Albrecht M, Guerra M, Braubach P, Halle O, Zhou-Suckow Z, Butz S, Jonigk D, Hansen G, Schultz C, Dittrich AM, Mall MA.

IL-17A from innate and adaptive lymphocytes contributes to inflammation and damage in cystic fibrosis lung disease

Eur Respir J. 2021 Jun 4;57(6):1900716. doi: 10.1183/13993003.00716-2019. PMID: 33303549. pubmed.ncbi.nlm.nih.gov/33303549/

McKelvey MC, Brown R, Ryan S, Mall MA, Weldon S, Taggart CC.

Proteases, Mucus, and Mucosal Immunity in Chronic Lung Disease

Int J Mol Sci. 2021 May 9;22(9):5018. doi: 10.3390/ijms22095018. PMID: 34065111; PMCID: PMC8125985. pubmed.ncbi.nlm.nih.gov/34065111/

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Transcriptional analysis identifies potential biomarkers and molecular regulators in acute malaria infection

Life Sci. 2021 Apr 1;270:119158. doi: 10.1016/j.lfs.2021.119158. Epub 2021 Feb 2. PMID: 33545200. pubmed.ncbi.nlm.nih.gov/33545200/

Brown R, Small DM, Doherty DF, Holsinger L, Booth R, Williams R, Ingram RJ, Elborn JS, Mall MA, Taggart CC, Weldon S.

Therapeutic Inhibition of Cathepsin S Reduces Inflammation and Mucus Plugging in Adult βENaC-Tg Mice.

Mediators Inflamm. 2021 Mar 19;2021:6682657. doi: 10.1155/2021/6682657. PMID: 33828414; PMCID: PMC8004367.

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From Clones to Buds and Branches. The Use of Lung Organoids to Mod Branching Morphogenesis Ex Vivo

Front Cell Dev Biol. 2021 Mar 4;9:631579. doi: 10.3389/fcell.2021.631579. PMID: 33748115; PMCID: PMC7969706. pubmed.ncbi.nlm.nih.gov/33748115/

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Induction of Krüppel-Like Factor 4 Mediates Polymorphonuclear Neutrophil Activation in Streptococcus pneumoniae Infection.

Front Microbiol. 2021 Feb 3;11:582070. doi: 10.3389/fmicb.2020.582070. PMID: 33613460; PMCID: PMC7887292. pubmed.ncbi.nlm.nih.gov/33613460/

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Collapse induration of alveoli is an ultrastructural finding in a COVID-19 patient

Eur Respir J. 2021 Jan 14:2004165. doi: 10.1183/13993003.04165-2020. Epub ahead of print. PMID: 33446606; PMCID: PMC7815985. pubmed.ncbi.nlm.nih.gov/33446606/

Frey DL, Boutin S, Dittrich SA, Graeber SY, Stahl M, Wege S, Herth FJF, Sommerburg O, Schultz C, Mall MA, Dalpke AH.

Relationship between airway dysbiosis, inflammation and lung function in adults with cystic fibrosis

J Cyst Fibros. 2021 Jan 8:S1569-1993(20)30954-1. doi: 10.1016/j.jcf.2020.12.022. Epub ahead of print. PMID: 33431308. pubmed.ncbi.nlm.nih.gov/33431308/

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Thiol-based redox switches in the major pathogen Staphylococcus aureus.

Biol Chemistry 2020 Dec 1.

Fritsch VN, Loi VV, Busche T, Tung QN, Lill R, Horvatek P, Wolz C, Kalinowski J, Antelmann H.

The alarmone (p)ppGpp confers tolerance to oxidative stress during the stationary phase by maintenance of redox and iron homeostasis in Staphylococcus aureus.

Free Radic Biol Med. 2020 Dec;161:351-364. doi: 10.1016/j.freeradbiomed.2020.10.322.

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Plasma mediators in patients with severe COVID-19 cause lung endothelial barrier failure

Eur Respir J. 2020 Nov 5;2002384. doi: 10.1183/13993003.02384-2020. Online ahead of print.

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J Infect Dis. 2020 Oct 12;jiaa639. doi: 10.1093/infdis/jiaa639.

Linzner N, Fritsch VN, Busche T, Tung QN, Loi VV, Bernhardt J, Kalinowski J, Antelmann H.

The plant-derived naphthoquinone lapachol causes an oxidative stress response in Staphylococcus aureus

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JCI Insight. 2020 Aug 20;5(16):e140076. doi: 10.1172/jci.insight.140076.

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Nature. 2020 Jul 29. doi: 10.1038/s41586-020-2598-9

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Ultra-High-Throughput Clinical Proteomics Reveals Classifiers of COVID-19 Infection

Cell Syst. 2020 Jul 22;11(1):11-24.e4.

Sauerhering L, Kupke A, Meier L, Dietzel E, Hoppe J, Gruber AD, Gattenloehner S, Witte B, Fink L, Hofmann N, Zimmermann T, Goesmann A, Nist A, Stiewe T, Becker S, Herold S, Peteranderl C.

Cyclophilin Inhibitors Restrict Middle East Respiratory Syndrome Coronavirus Via Interferon λ In Vitro And In Mice

Eur Respir J. 2020 Jul 2; 1901826.

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Nat Biotechnol. 2020 Aug;38(8):970-979

Taghizadeh S, Heiner M, Vazquez-Armendariz AI, Wilhelm J, Herold S, Chen C, Zhang JS, Bellusci S.

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Conditional deletion of Nedd4-2 in lung epithelial cells causes progressive pulmonary fibrosis in adult mice.

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Nat Nanotechnol. 2020 May;15(5):373-379

Brown R, Paulsen M, Schmidt S, Schatterny J, Frank A, Hirtz S, Delaney R, Doherty D, Hagner M, Taggart C, Weldon S, Mall MA

Lack of IL-1 receptor signaling reduces spontaneous airway eosinophilia in juvenile mice with muco-obstructive lung disease.

Am J Respir Cell Mol Biol. 2020 Mar;62(3):300-309.

Hagner M, Frey DL, Guerra M, Dittrich AS, Halls VS, Wege S, Herth FJF, Schultz C, Mall MA

New method for rapid and dynamic quantification of elastase activity on sputum neutrophils from patients with cystic fibrosis using flow cytometry.

Eur Respir J. 2020 Mar 5. pii: 1902355

Rohilla S, Krämer B, Koberling F, Gregor I, Hocke AC.

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Toward a universal flu vaccine.

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McKelvey MC, Weldon S, McAuley DF, Mall MA, Taggart CC

Targeting proteases in cystic fibrosis lung disease: Paradigms, progress, and potential.

Am J Respir Crit Care Med. 2020 Jan 15;201(2):141-147.

Mall MA, Mayer-Hamblett N, Rowe SM

Cystic fibrosis: Emergence of highly effective targeted therapeutics and potential clinical implications.

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The MarR-Type Repressor MhqR Confers Quinone and Antimicrobial Resistance in Staphylococcus aureus

Antioxid Redox Signal. 2019 Dec 1;31(16):1235-1252. doi: 10.1089/ars.2019.7750.

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Free Radic Biol Med. 2019 Aug 1;139:55-69. doi: 10.1016/j.freeradbiomed.2019.05.018.

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Staphylococcus aureus Uses the Bacilliredoxin (BrxAB)/Bacillithiol Disulfide Reductase (YpdA) Redox Pathway to Defend Against Oxidative Stress Under Infections

Front Microbiol. 2019 Jun 18;10:1355. doi: 10.3389/fmicb.2019.01355.

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A novel European H5N8 influenza A virus has increased virulence in ducks but low zoonotic potential

Emerg Microbes Infect. 2018 Jul 19;7(1):132.

Kalymbetova TV, Selvakumar B, Rodriguez-Castillo JA, Gunjak M, Malainou C, Heindl MR, Moiseenko A, Chao CM, Vadasz I, Mayer K, Lohmeyer J, Bellusci S, Bottcher-Friebertshauser E, Seeger W, Herold S, Morty RE

Resident alveolar macrophages are master regulators of arrested alveolarization in experimental bronchopulmonary dysplasia.

J Pathol. 2018 Jun;245(2):153-159

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Herta T, Bhattacharyya A, Bollensdorf C, Kabus C, García P, Suttorp N, Hippenstiel S, Zahlten J

DNA-release by Streptococcus pneumoniae autolysin LytA induced Krueppel-like factor 4 expression in macrophages.

Sci Rep. 2018 Apr 10;8(1):5723

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Perniss A, Schmidt N, Gurtner C, Dietert K, Schwengers O, Weigel M, Hempe J, Ewers C, Pfeil U, Gärtner U, Gruber AD, Hain T, Kummer W

Bordetella pseudohinzii targets cilia and impairs tracheal cilia-driven transport in naturally acquired infection in mice.

Sci Rep. 2018 Apr 9;8(1):5681

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Ugolini M, Gerhard J, Burkert S, Jensen KJ, Georg P, Ebner F, Thada S, Dietert K, Helbig ET, Opitz B, Kurth F, Dittrich N, Sumanlatha G, Blander JM, Gruber AD, Hartmann S, Boekschoten MV, Suttorp N, Müller M, Jungersen G, Schumann RR, Sander LE

Recognition of microbial viability via TLR8 promotes T follicular helper cell differentiation and vaccine responses.

Nat Immunol  2018

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Dames C, Winek K, Beckers Y, Engel O, Meisel M, Meisel C

Immunomodulatory treatment with systemic GM-CSF augments pulmonary immune responses and improves neurological outcome after experimental stroke.

J Neuroimmunol. 2018 Mar 9. pii: S0165-5728(17)30548-9

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Gutbier B, Neuhauß AK, Reppe K, Ehrler C, Santel A, Kaufmann J, Scholz M, Weissmann N, Morawietz L, Mitchell TJ, Aliberti S, Hippenstiel S, Suttorp N, Witzenrath M; CAPNETZ and PROGRESS study groups

Prognostic and Pathogenic Role of Angiopoietin-1 and -2 in Pneumonia.

Am J Respir Crit Care Med. 2018 Feb 15

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Shrivastav A, Dabrowski AN, Conrad C, Baal N, Hackstein H, Plog S, Dietert K, Gruber AD, N'Guessan PD, Aly S, Suttorp N, Zahlten J

Peptidoglycan Recognition Protein 3 Does Not Alter the Outcome of Pneumococcal Pneumonia in Mice.

Front Microbiol. 2018 Feb 1;9:103

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Becker SC, Szyska M, Mensen A, Hellwig K, Otto R, Olfe L, Volk HD, Dörner T, Dörken B, Scheibenbogen C, Schröder J, Hocke AC, Kang Na Il

A comparative analysis of human bone marrow-resident and peripheral memory B cells.

J Allergy Clin Immunol. 2018 Jan 31

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Dietert K, Nouailles G, Gutbier B, Reppe K, Berger S, Jiang X, Schauer AE, Hocke AC, Herold S, Slevogt H, Witzenrath M, Suttorp N, Gruber AD

Digital Image Analyses on Whole Lung Slides in Mouse Models of Acute Pneumonia.

Am J Respir Cell Mol Biol. 2018 Jan 23.

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Nerlich A, Mieth M, Letsiou E, Fatykhova D, Zscheppang K, Matsushima AI, Meyer TF, Paasch L, Mitchell T, Tönnies M, Bauer TT, Schneider P, Neudecker J, Rückert J, Eggeling S, Schimek M, Witzenrath M, Suttorp N, Hippenstiel S, Hocke AC

Pneumolysin induced mitochondrial dysfunction leads to release of mitochondrial DNA.

Scientific Reports (2018) 8:182

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Gutbier B, Schönrock SM, Ehrler C, Haberberger R, Dietert K, Gruber AD, Kummer W, Michalik L, Kübler WM, Hocke AC, Szymanski K, Letsiou E, Lüth A, Schumacher F, Kleuser B, Mitchell TJ, Bertrams W, Schmeck B, Treue D, Klauschen F, Bauer TT, Tönnies M,

Sphingosine kinase 1 regulates inflammation and contributes to acute lung injury in pneumococcal pneumonia via the S1P receptor 2.

Crit Care Med. 2018 Jan 2.

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Heß N, Waldow F, Kohler TP, Rohde M, Kreikemeyer B, Gómez-Mejia A, Hain T, Schwudke D, Vollmer W, Hammerschmidt S, Gisch N

LTA deficiency permits normal growth but impairs virulence of Streptococcus pneumoniae.

Nat Commun. 2017 Dec 12;8(1):2093

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Dietert K, Gutbier B, Wienhold SM, Reppe K, Jiang X, Yao L, Chaput C, Naujoks J, Brack M, Kupke A, Peteranderl C, Becker S, von Lachner C, Baal N, Slevogt H, Hocke AC, Witzenrath M, Opitz B, Herold S, Hackstein H, Sander LE, Suttorp N, Gruber AD

Spectrum of pathogen- and model-specific histopathologies in mouse models of acute pneumonia.

PLoS One. 2017 Nov 20;12(11):e0188251

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van de Sandt CE, Bárcena M, Koster AJ, Kasper J, Kirkpatrick CJ, Scott DP, de Vries RD, Herold S, Rimmelzwaan GF, Kuiken T, Short KR

Human CD8+ T Cells Damage Noninfected Epithelial Cells during Influenza Virus Infection In Vitro.

Am J Respir Cell Mol Biol. 2017 Nov;57(5):536-546

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Schulz C, Lai X, Bertrams W, Jung AL, Sittka-Stark A, Herkt CE, Janga H, Zscheppang K, Stielow C, Schulte L, Hippenstiel S, Vera J, Schmeck B

THP-1-derived macrophages render lung epithelial cells hypo-responsive to Legionella pneumophila - a systems biology study.

Sci Rep. 2017 Sep 20;7(1):11988

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Zscheppang K, Berg J, Hedtrich S, Verheyen L, Wagner DE, Suttorp N, Hippenstiel S, Hocke AC

Human pulmonary 3D models for translational research.

Biotechnol J. 2017 Sep 2

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Wygrecka M, Kosanovic D, Wujak L, Reppe K, Henneke I, Frey H, Didiasova M, Kwapiszewska G, Marsh LM, Baal N, Hackstein H, Zakrzewicz D, Müller-Redetzky HC, de Maat S, Maas C, Nolte MW, Panousis C, Schermuly RT, Seeger W, Witzenrath M, Schaefer L, Markart

Antihistone Properties of C1 Esterase Inhibitor Protect against Lung Injury.

Am J Respir Crit Care Med. 2017 Jul 15;196(2):186-199

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Berg J, Zscheppang K, Fatykhova D, Tönnies M, Bauer TT, Schneider P, Neudecker J, Rückert JC, Eggeling S, Schimek M, Gruber AD, Suttorp N, Hippenstiel S, Hocke AC

Tyk2 as a target for immune regulation in human viral/bacterial pneumonia.

Eur Respir J. 2017 Jul 13;50(1)

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Peter A, Fatykhova D, Kershaw O, Gruber AD, Rueckert J, Neudecker J, Toennies M, Bauer TT, Schneider P, Schimek M, Eggeling S, Suttorp N, Hocke AC, Hippenstiel S

Localization and pneumococcal alteration of junction proteins in the human alveolar-capillary compartment.

Histochem Cell Biol. 2017 Jun;147(6):707-719

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Lippitsch A, Chukovetskyi Y, Baal N, Bein G, Hackstein H

Unique high and homogenous surface expression of the transferrin receptor CD71 on murine plasmacytoid dendritic cells in different tissues.

Cell Immunol. 2017 Jun;316:41-52

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Gerlach T, Hensen L, Matrosovich T, Bergmann J, Winkler M, Peteranderl C, Klenk HD, Weber F, Herold S, Pöhlmann S, Matrosovich M

pH Optimum of Hemagglutinin-Mediated Membrane Fusion Determines Sensitivity of Influenza A Viruses to the Interferon-Induced Antiviral State and IFITMs.

J Virol. 2017 May 12;91(11). pii: e00246-17

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Peteranderl C, Sznajder JI, Herold S and Lecuona E

Inflammatory responses regulating alveolar ion transport during pulmonary infections.

Front Immunol. 2017 Apr 18;8:446

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Peteranderl C, Herold S

The Impact of the Interferon/TNF-Related Apoptosis-Inducing Ligand Signaling Axis on Disease Progression in Respiratory Viral Infection and Beyond.

Front Immunol. 2017 Mar 22;8:313

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Schierhorn KL, Jolmes F, Bespalowa J, Saenger S, Peteranderl C, Dzieciolowski J, Budt M, Pleschka S, Herrmann A, Herold S, Wolff T

Influenza A virus virulence depends on two amino acids in the N-terminal domain of its NS1 protein facilitating inhibition of PKR.

J Virol. 2017 Mar 1. pii: JVI.00198-17

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Hocke AC, Suttorp N, and Hippenstiel S

Human lung ex vivo infection models.

Cell Tissue Res. 2017 Mar;367(3):511-524

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Chao CM, Yahya F, Moiseenko A, Tiozzo C, Shrestha A, Ahmadvand N, El Agha E, Quantius J, Dilai S, Kheirollahi V, Jones M, Wilhem J, Carraro G, Ehrhardt H, Zimmer KP, Barreto G, Ahlbrecht K, Morty RE, Herold S, Abellar RG, Seeger W, Schermuly R, Zhang JS,

Fgf10 deficiency is causative for lethality in a mouse model of bronchopulmonary dysplasia.

J Pathol. 2017 Jan;241(1):91-103

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Schaefer MB, Schaefer CA, Schifferings S, Kuhlmann CR, Urban A, Benscheid U, Fischer T, Hecker M, Morty RE, Vadasz I, Herold S, Witzenrath M, Seeger W, Erdogan A, Mayer K

N-3 vs. n-6 fatty acids differentially influence calcium signalling and adhesion of inflammatory activated monocytes: impact of lipid rafts.

Inflamm Res. 2016 Nov;65(11):881-894

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Peteranderl C, Herold S, Schmoldt C

Human Influenza Virus Infections.

Semin Respir Crit Care Med. 2016 Aug;37(4):487-500

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Rabes A, Suttorp N, Opitz B

Inflammasomes in Pneumococcal Infection: Innate Immune Sensing and Bacterial Evasion Strategies.

Curr Top Microbiol Immunol. 2016;397:215-27

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Hackstein H, Tschipakow I, Bein G, Nold P, Brendel C, Baal N

Contact-dependent abrogation of bone marrow-derived plasmacytoid dendritic cell differentiation by murine mesenchymal stem cells.

Biochem Biophys Res Commun. 2016 Jul 15;476(1):15-20

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Quantius J, Schmoldt C, Vazquez-Armendariz AI, Becker C, El Agha E, Wilhelm J, Morty RE, Vadász I, Mayer K, Gattenloehner S, Fink L, Matrosovich M, Li X, Seeger W, Lohmeyer J, Bellusci S, Herold S

Influenza Virus Infects Epithelial Stem/Progenitor Cells of the Distal Lung: Impact on Fgfr2b-Driven Epithelial Repair.

PLoS Pathog. 2016 Jun 20;12(6):e1005544

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Mostafa A, Abdelwhab el-SM, Slanina H, Hussein MA, Kuznetsova I, Schüttler CG, Ziebuhr J, Pleschka S

Phylogenetic analysis of human influenza A/H3N2 viruses isolated in 2015 in Germany indicates significant genetic divergence from vaccine strains.

Arch Virol. 2016 Jun;161(6):1505-15

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Winek K, Engel O, Koduah P, Heimesaat MM, Fischer A, Bereswill S, Dames C, Kershaw O, Gruber AD, Curato C, Oyama N, Meisel C, Meisel A, Dirnagl U

Depletion of cultivatable gut microbiota by broad-spectrum antibiotic pretreatment worsens outcome after murine stroke.

Stroke. 2016 May;47(5):1354-63

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Peteranderl C, Morales-Nebreda L, Selvakumar B, Lecuona E, Vadász I, Morty RE, Schmoldt C, Bespalowa J, Wolff T, Pleschka S, Mayer K, Gattenloehner S, Fink L, Lohmeyer J, Seeger W, Sznajder JI, Mutlu GM, Budinger GR, Herold S

Macrophage-epithelial paracrine crosstalk inhibits lung edema clearance during influenza infection.

J Clin Invest. 2016 Apr 1;126(4):1566-80

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Griss K, Bertrams W, Sittka-Stark A, Seidel K, Stielow C, Hippenstiel S, Suttorp N, Eberhardt M, Wilhelm J, Vera J, Schmeck B

MicroRNAs constitute a negative feedback loop in Streptococcus pneumoniae induced macrophage activation.

J Infect Dis. 2016 Mar 16

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Short K, Kasper J, van der Aa S, Andeweg AC, Zaaraoui-Boutahar F, Goeijenbier M, Richard M, Herold S, Becker C, Scott DP, Limpens R, Koster AJ, Barcena M, Fouchier R, Kirkpatrick CJ, Kuiken T

Influenza virus damages the alveolar barrier by disrupting epithelial cell tight junctions.

Eur Respir J. 2016 Mar;47(3):954-66

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Naujoks J, Tabeling C, Dill BD, Hoffmann C, Brown AS, Kunze M, Kempa S, Peter A, Mollenkopf HJ, Dorhoi A, Kershaw O, Gruber AD, Sander LE, Witzenrath M, Herold S, Nerlich A, Hocke AC, van Driel I, Suttorp N, Bedoui S, Hilbi H, Trost M, Opitz B

IFNs Modify the Proteome of Legionella-Containing Vacuoles and Restrict Infection Via IRG1-Derived Itaconic Acid.

PLoS Pathog. 2016 Feb 1;12(2)

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Reppe K, Radünzel P, Dietert K, Tschernig T, Wolff T, Hammerschmidt S, Gruber AD, Suttorp N, Witzenrath M

Pulmonary immunostimulation with MALP-2 in influenza virus-infected mice increases survival after pneumococcal superinfection.

Infect Immun. 2015 Dec;83(12):4617-29

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Meisel A, Smith CJ

Stroke: Preventive antibiotics for stroke-associated pneumonia.

Nat Rev Neurol. 2015 Nov 3

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Engel O, Akyüz L, da Costa Goncalves AC, Winek K, Dames C, Thielke M, Herold S, Böttcher C, Priller J, Volk HD, Dirnagl U, Meisel C, Meisel A

Cholinergic pathway suppresses pulmonary innate immunity facilitating pneumonia after stroke.

Stroke. 2015 Nov;46(11):3232-40

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Hackstein H, Lippitsch A, Krug P, Schevtschenko I, Kranz S, Hecker M, Dietert K, Gruber AD, Bein G, Brendel C, Baal N

Prospectively defined murine mesenchymal stem cells inhibit Klebsiella pneumoniae-induced acute lung injury and improve pneumonia survival.

Respir Res. 2015 Oct 6;16:123

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Zahlten J, Herta T, Kabus C, Steinfeldt M, Kershaw O, García P, Hocke AC, Gruber AD, Hübner RH, Steinicke R, Doehn JM, Suttorp N, Hippenstiel S

Role of Pneumococcal Autolysin for KLF4 Expression and Chemokine Secretion in Lung Epithelium.

Am J Respir Cell Mol Biol. 2015 Oct;53(4):544-54

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Meisel A, Smith CJ

Prevention of stroke-associated pneumonia: where next?

Lancet. 2015 Sep 3. pii: S0140-6736(15)00127-0

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Fatykhova D, Rabes A, Machnik C, Guruprasad K, Pache F, Berg J, Toennies M, Bauer TT, Schneider P, Schimek M, Eggeling S, Mitchell TJ, Mitchell AM, Hilker R, Hain T, Suttorp N, Hippenstiel S, Hocke AC, Opitz B

Serotype 1 and 8 Pneumococci Evade Sensing by Inflammasomes in Human Lung Tissue.

PLoS One. 2015 Aug 28;10(8):e0137108

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Recum-Knepper J, Sadewasser A, Weinheimer VK, Wolff T

Fluorescence-Activated Cell Sorting-Based Analysis Reveals an Asymmetric Induction of Interferon-Stimulated Genes in Response to Seasonal Influenza A Virus.

J Virol. 2015 Jul 15;89(14):6982-93

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Mühlbauer D, Dzieciolowski J, Hardt M, Hocke A, Schierhorn KL, Mostafa A, Müller C, Wisskirchen C, Herold S, Wolff T, Ziebuhr J, Pleschka S

Influenza virus-induced caspase-dependent enlargement of nuclear pores promotes nuclear export of viral ribonucleoprotein complexes.

J Virol. 2015 Jun 1;89(11):6009-21

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Jung S, von Thulen T, Laukemper V, Pigisch S, Hangel D, Wagner H, Kaufmann A, Bauer S

A single naturally occurring 2'-O-methylation converts a TLR7- and TLR8-activating RNA into a TLR8-specific ligand.

A single naturally occurring 2'-O-methylation converts a TLR7- and TLR8-activating RNA into a TLR8-specific ligand.

https://www.ncbi.nlm.nih.gov/pubmed/25785446

Hecker M, Linder T, Ott J, Walmrath HD, Lohmeyer J, Vadász I, Marsh LM, Herold S, Reichert M, Buchbinder A, Morty RE, Bausch B, Fischer T, Schulz R, Grimminger F, Witzenrath M, Barnes M, Seeger W, Mayer K

Immunomodulation by lipid emulsions in pulmonary inflammation: a randomized controlled trial.

Crit Care. 2015 May 12;19:226

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Müller-Redetzky HC, Wienhold SM, Berg J, Hocke AC, Hippenstiel S, Hellwig K, Gutbier B, Opitz B, Neudecker J, Rückert J, Gruber AC, Kershaw O, Mayer K,  Suttorp N, Witzenrath M

Moxifloxacin is not anti-inflammatory in experimental pneumococcal pneumonia.

J Antimicrob Chemother. 2015 Mar;70(3):830-40

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Kishore AK, Vail A, Chamorro A, Garau J, Hopkins SJ, Di Napoli M, Kalra L, Langhorne P, Montaner J, Roffe C, Rudd AG, Tyrrell PJ, van de Beek D, Woodhead M, Meisel A, Smith CJ

How is pneumonia diagnosed in clinical stroke research? A systematic review and meta-analysis.

Stroke. 2015 May;46(5):1202-9.

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Tabeling C, Yu H, Wang L, Ranke H, Goldenberg NM, Zabini D, Noe E, Krauszman A, Gutbier B, Yin J, Schaefer M, Arenz C, Hocke AC, Suttorp N, Proia RL, Witzenrath M, Kuebler WM

CFTR and sphingolipids mediate hypoxic pulmonary vasoconstriction.

Proc Natl Acad Sci U S A. 2015 Mar 31;112(13):E1614-23

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Zahlten J, Herta T, Kabus C, Steinfeldt M, Kershaw O, García P, Hocke AC, Gruber AD, Hübner RH, Steinicke R, Doehn JM, Suttorp N, Hippenstiel S

Pneumococci LytA-dependent KLF4 Expression Terminates IL-8 Secretion in Lung Epithelium.

Am J Respir Cell Mol Biol. 2015 Mar 10

http://www.ncbi.nlm.nih.gov/pubmed/25756955

Rabes A, Zimmermann S, Reppe K, Lang R, Seeberger PH, Suttorp N, Witzenrath M, Lepenies B, Opitz B

The C-type lectin receptor Mincle binds to Streptococcus pneumoniae but plays a limited role in the anti-pneumococcal innate immune response.

PLoS One. 2015 Feb 6;10(2):e0117022

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Müller-Redetzky HC, Felten M, Hellwig K, Wienhold SM, Naujoks J, Opitz B, Kershaw O, Gruber AD, Suttorp N, Witzenrath M

Increasing the inspiratory time and I:E ratio during mechanical ventilation aggravates ventilator-induced lung injury in mice.

Critical Care 2015, 19:23

http://www.ncbi.nlm.nih.gov/pubmed/25888164

Zahlten J, Kim YJ, Doehn JM, Pribyl T, Hocke AC, García P, Hammerschmidt S, Suttorp N, Hippenstiel S, Hübner RH

Streptococcus pneumoniae-Induced Oxidative Stress in Lung Epithelial Cells Depends on Pneumococcal Autolysis and Is Reversible by Resveratrol.

J Infect Dis. 2015 Jun 1;211(11):1822-1830

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Dames C, Akyüz L, Reppe K, Tabeling C, Dietert K, Kershaw O, Gruber AD, Meisel C, Meisel A, Witzenrath M, Engel O

Miniaturized bronchoscopy enables unilateral investigation, application, and sampling in mice.

Am J Respir Cell Mol Biol. 2014 Dec;51(6):730-7

http://www.ncbi.nlm.nih.gov/pubmed/24960575

Noe E, Tabeling C, Doehn JM, Naujoks J, Opitz B, Hippenstiel S, Witzenrath M, Klopfleisch R

Juvenile megaesophagus in PKCα-deficient mice is associated with an increase in the segment of the distal esophagus lined by smooth muscle cells.

Ann Anat. 2014 Sep;196(5):365-71

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Hecker M, Ott J, Sondermann C, Schaefer M, Obert M, Hecker A, Morty RE, Vadasz I, Herold S, Rosengarten B, Witzenrath M, Seeger W, Mayer K

Immunomodulation by fish-oil containing lipid emulsions in murine acute respiratory distress syndrome.

Crit Care. 2014 Apr 29;18(2):R85

http://www.ncbi.nlm.nih.gov/pubmed/24780004

Herold S, Hoegner K, Vadász I, Gessler T, Wilhelm J, Mayer K, Morty RE, Walmrath

Inhaled GM-CSF as treatment of pneumonia-associated ARDS

Am J Respir Crit Care Med. 2014 Mar 1;189(5):609-11

Malczyk M, Veith C, Fuchs B, Hofmann K, Storch U, Schermuly RT, Witzenrath M, Ah

Classical Transient Receptor Potential Channel 1 in Hypoxia-induced Pulmonary Hypertension.

Am J Respir Crit Care Med. 2013 Dec 15;188(12):1451-9.

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Schütz F, Hackstein H

Identification of novel dendritic cell subset markers in human blood.

Biochem Biophys Res Commun. 2013 Dec 7. pii: S0006-291X(13)02024-X. doi: 10.1016/j.bbrc.2013.11.112.

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Tabeling C, Scheer H, Schönrock SM, Runge F, Gutbier B, Lienau J, Hamelmann E, Opitz B, Suttorp N, Mayer K, Behrens GM, Tschernig T, Witzenrath M.

NOD1 Ligation Suppressed Murine Allergen-Specific T Cell Proliferation and Airway Hyperresponsiveness.

Am J Respir Cell Mol Biol. 2013 Nov 26.

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Chaput C, Sander LE, Suttorp N, Opitz B

NOD-Like Receptors in Lung Diseases.

Front Immunol. 2013, 4, 393.

http://www.ncbi.nlm.nih.gov/pubmed/24312100

Knepper J, Schierhorn KL, Becher A, Budt M, Tönnies M, Bauer TT, Schneider P, Neudecker J, Rückert JC, Gruber AD, Suttorp N, Schweiger B, Hippenstiel S, Hocke AC, Wolff T

The novel human influenza A(H7N9) virus is naturally adapted to efficient growth in human lung tissue

MBio. 2013 Oct 8;4(5). pii: e00601-13. doi: 10.1128/mBio.00601-13.

http://www.ncbi.nlm.nih.gov/pubmed/24105764

Hocke AC, Becher A, Knepper J, Peter A, Holland G, Tönnies M, Bauer TT, Schneider P, Neudecker J, Muth D, Wendtner CM, Rückert JC, Drosten C, Gruber AD, Laue M, Suttorp N, Hippenstiel S, Wolff T.

Emerging Human Middle East Respiratory Syndrome Coronavirus Causes Widespread Infection and Alveolar Damage in Human Lungs.

Am J Respir Crit Care Med. 2013 Oct 1;188(7):882-886.

http://www.ncbi.nlm.nih.gov/pubmed/24083868

Hackstein H, Kranz S, Lippitsch A, Wachtendorf A, Kershaw O, Gruber AD, Michel G, Lohmeyer J, Bein G, Baal N, Herold S.

Modulation of respiratory dendritic cells during Klebsiella pneumonia infection.

Resp Res 2013 Sept 17;14(1):91 [Epub ahead of print].

http://www.ncbi.nlm.nih.gov/pubmed/24044871

Herold S, Gabrielli NM, Vadasz I.

Novel concepts of acute lung injury and alveolo-capillary barrier dysfunction.

Am J Physiol Lung Cell Mol Physiol. 13 Sept 2013, DOI: 10.1152/ajplung.00232.2013

http://www.ncbi.nlm.nih.gov/pubmed/24039257

Bayat B, Tjahjono Y, Sydykov A, Werth S, Hippenstiel S, Weissmann N, Sachs UJ, Santoso S.

Anti-Human Neutrophil Antigen-3a Induced Transfusion-Related Acute Lung Injury in Mice by Direct Disturbance of Lung Endothelial Cells.

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