Transregio SFB-TR 84 “Innate Immunity of the Lung: Mechanisms of Pathogen Attack and Host Defence in Pneumonia“


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Scheller N, Herold S, Kellner R, Bertrams W, Jung AL, Janga H, Greulich T, Schulte LN, Vogelmeier CF, Lohmeyer J, Schmeck B.

Pro-viral miRNAs detected in BALF extracellular vesicles of patients with influenza virus-induced ARDS.

J Infect Dis. 2018 Sep 15

Kalymbetova TV, Selvakumar B, Rodriguez-Castillo JA, Gunjak M, Malainou C, Heindl MR, Moiseenko A, Chao CM, Vadasz I, Mayer K, Lohmeyer J, Bellusci S, Bottcher-Friebertshauser E, Seeger W, Herold S, Morty RE

Resident alveolar macrophages are master regulators of arrested alveolarization in experimental bronchopulmonary dysplasia.

J Pathol. 2018 Jun;245(2):153-159

Dietert K, Nouailles G, Gutbier B, Reppe K, Berger S, Jiang X, Schauer AE, Hocke AC, Herold S, Slevogt H, Witzenrath M, Suttorp N, Gruber AD

Digital Image Analyses on Whole Lung Slides in Mouse Models of Acute Pneumonia.

Am J Respir Cell Mol Biol. 2018 Jan 23.

Dietert K, Gutbier B, Wienhold SM, Reppe K, Jiang X, Yao L, Chaput C, Naujoks J, Brack M, Kupke A, Peteranderl C, Becker S, von Lachner C, Baal N, Slevogt H, Hocke AC, Witzenrath M, Opitz B, Herold S, Hackstein H, Sander LE, Suttorp N, Gruber AD

Spectrum of pathogen- and model-specific histopathologies in mouse models of acute pneumonia.

PLoS One. 2017 Nov 20;12(11):e0188251

van de Sandt CE, Bárcena M, Koster AJ, Kasper J, Kirkpatrick CJ, Scott DP, de Vries RD, Herold S, Rimmelzwaan GF, Kuiken T, Short KR

Human CD8+ T Cells Damage Noninfected Epithelial Cells during Influenza Virus Infection In Vitro.

Am J Respir Cell Mol Biol. 2017 Nov;57(5):536-546

Gerlach T, Hensen L, Matrosovich T, Bergmann J, Winkler M, Peteranderl C, Klenk HD, Weber F, Herold S, Pöhlmann S, Matrosovich M

pH Optimum of Hemagglutinin-Mediated Membrane Fusion Determines Sensitivity of Influenza A Viruses to the Interferon-Induced Antiviral State and IFITMs.

J Virol. 2017 May 12;91(11). pii: e00246-17

Peteranderl C, Sznajder JI, Herold S and Lecuona E

Inflammatory responses regulating alveolar ion transport during pulmonary infections.

Front Immunol. 2017 Apr 18;8:446

Peteranderl C, Herold S

The Impact of the Interferon/TNF-Related Apoptosis-Inducing Ligand Signaling Axis on Disease Progression in Respiratory Viral Infection and Beyond.

Front Immunol. 2017 Mar 22;8:313

Sadewasser A, Paki K, Eichelbaum K, Bogdanow B, Saenger S, Budt M, Lesch M, Hinz KP, Herrmann A, Meyer TF, Karlas A, Selbach M, Wolff T

Quantitative proteomic approach identifies Vpr binding protein as novel host factor supporting influenza A virus infections in human cells.

Mol Cell Proteomics. 2017 Mar 13

Schierhorn KL, Jolmes F, Bespalowa J, Saenger S, Peteranderl C, Dzieciolowski J, Budt M, Pleschka S, Herrmann A, Herold S, Wolff T

Influenza A virus virulence depends on two amino acids in the N-terminal domain of its NS1 protein facilitating inhibition of PKR.

J Virol. 2017 Mar 1. pii: JVI.00198-17

Chao CM, Yahya F, Moiseenko A, Tiozzo C, Shrestha A, Ahmadvand N, El Agha E, Quantius J, Dilai S, Kheirollahi V, Jones M, Wilhem J, Carraro G, Ehrhardt H, Zimmer KP, Barreto G, Ahlbrecht K, Morty RE, Herold S, Abellar RG, Seeger W, Schermuly R, Zhang JS, Minoo P, Bellusci S

Fgf10 deficiency is causative for lethality in a mouse model of bronchopulmonary dysplasia.

J Pathol. 2017 Jan;241(1):91-103

Schaefer MB, Schaefer CA, Schifferings S, Kuhlmann CR, Urban A, Benscheid U, Fischer T, Hecker M, Morty RE, Vadasz I, Herold S, Witzenrath M, Seeger W, Erdogan A, Mayer K

N-3 vs. n-6 fatty acids differentially influence calcium signalling and adhesion of inflammatory activated monocytes: impact of lipid rafts.

Inflamm Res. 2016 Nov;65(11):881-894

Peteranderl C, Herold S, Schmoldt C

Human Influenza Virus Infections.

Semin Respir Crit Care Med. 2016 Aug;37(4):487-500

Quantius J, Schmoldt C, Vazquez-Armendariz AI, Becker C, El Agha E, Wilhelm J, Morty RE, Vadász I, Mayer K, Gattenloehner S, Fink L, Matrosovich M, Li X, Seeger W, Lohmeyer J, Bellusci S, Herold S

Influenza Virus Infects Epithelial Stem/Progenitor Cells of the Distal Lung: Impact on Fgfr2b-Driven Epithelial Repair.

PLoS Pathog. 2016 Jun 20;12(6):e1005544

Mostafa A, Abdelwhab el-SM, Slanina H, Hussein MA, Kuznetsova I, Schüttler CG, Ziebuhr J, Pleschka S

Phylogenetic analysis of human influenza A/H3N2 viruses isolated in 2015 in Germany indicates significant genetic divergence from vaccine strains.

Arch Virol. 2016 Jun;161(6):1505-15

Peteranderl C, Morales-Nebreda L, Selvakumar B, Lecuona E, Vadász I, Morty RE, Schmoldt C, Bespalowa J, Wolff T, Pleschka S, Mayer K, Gattenloehner S, Fink L, Lohmeyer J, Seeger W, Sznajder JI, Mutlu GM, Budinger GR, Herold S

Macrophage-epithelial paracrine crosstalk inhibits lung edema clearance during influenza infection.

J Clin Invest. 2016 Apr 1;126(4):1566-80

Short K, Kasper J, van der Aa S, Andeweg AC, Zaaraoui-Boutahar F, Goeijenbier M, Richard M, Herold S, Becker C, Scott DP, Limpens R, Koster AJ, Barcena M, Fouchier R, Kirkpatrick CJ, Kuiken T

Influenza virus damages the alveolar barrier by disrupting epithelial cell tight junctions.

Eur Respir J. 2016 Mar;47(3):954-66 26743480

Naujoks J, Tabeling C, Dill BD, Hoffmann C, Brown AS, Kunze M, Kempa S, Peter A, Mollenkopf HJ, Dorhoi A, Kershaw O, Gruber AD, Sander LE, Witzenrath M, Herold S, Nerlich A, Hocke AC, van Driel I, Suttorp N, Bedoui S, Hilbi H, Trost M, Opitz B

IFNs Modify the Proteome of Legionella-Containing Vacuoles and Restrict Infection Via IRG1-Derived Itaconic Acid.

PLoS Pathog. 2016 Feb 1;12(2)

Reppe K, Radünzel P, Dietert K, Tschernig T, Wolff T, Hammerschmidt S, Gruber AD, Suttorp N, Witzenrath M

Pulmonary immunostimulation with MALP-2 in influenza virus-infected mice increases survival after pneumococcal superinfection.

Infect Immun. 2015 Dec;83(12):4617-29

Engel O, Akyüz L, da Costa Goncalves AC, Winek K, Dames C, Thielke M, Herold S, Böttcher C, Priller J, Volk HD, Dirnagl U, Meisel C, Meisel A

Cholinergic pathway suppresses pulmonary innate immunity facilitating pneumonia after stroke.

Stroke. 2015 Nov;46(11):3232-40

Recum-Knepper J, Sadewasser A, Weinheimer VK, Wolff T

Fluorescence-Activated Cell Sorting-Based Analysis Reveals an Asymmetric Induction of Interferon-Stimulated Genes in Response to Seasonal Influenza A Virus.

J Virol. 2015 Jul 15;89(14):6982-93

Mühlbauer D, Dzieciolowski J, Hardt M, Hocke A, Schierhorn KL, Mostafa A, Müller C, Wisskirchen C, Herold S, Wolff T, Ziebuhr J, Pleschka S

Influenza virus-induced caspase-dependent enlargement of nuclear pores promotes nuclear export of viral ribonucleoprotein complexes.

J Virol. 2015 Jun 1;89(11):6009-21

Hecker M, Linder T, Ott J, Walmrath HD, Lohmeyer J, Vadász I, Marsh LM, Herold S, Reichert M, Buchbinder A, Morty RE, Bausch B, Fischer T, Schulz R, Grimminger F, Witzenrath M, Barnes M, Seeger W, Mayer K

Immunomodulation by lipid emulsions in pulmonary inflammation: a randomized controlled trial.

Crit Care. 2015 May 12;19:226

Hecker M, Ott J, Sondermann C, Schaefer M, Obert M, Hecker A, Morty RE, Vadasz I, Herold S, Rosengarten B, Witzenrath M, Seeger W, Mayer K

Immunomodulation by fish-oil containing lipid emulsions in murine acute respiratory distress syndrome.

Crit Care. 2014 Apr 29;18(2):R85

Peters DM, Vadász I, Wujak L, Wygrecka M, Olschewski A, Becker C, Herold S, Papp

TGF-ß directs trafficking of the epithelial sodium channel ENaC which has implications for ion and fluid transport in acute lung injury.

Proc Natl Acad Sci U S A. 2014 Jan 21;111(3):E374-83

Herold S, Hoegner K, Vadász I, Gessler T, Wilhelm J, Mayer K, Morty RE, Walmrath

Inhaled GM-CSF as treatment of pneumonia-associated ARDS

Am J Respir Crit Care Med. 2014 Mar 1;189(5):609-11

Witsch TJ, Turowski P, Sakkas E, Niess G, Becker S, Herold S, Mayer K, Vadász I, Roberts JD Jr, Seeger W, Morty RE.

Deregulation of the lysyl hydroxylase matrix cross-linking system in experimental and clinical bronchopulmonary dysplasia.

Am J Physiol Lung Cell Mol Physiol. 2013 Nov 27.

Schwartze JT, Becker S, Sakkas E, Wujak LA, Niess G, Usemann J, Reichenberger F, Herold S, Vadasz I, Mayer K, Seeger W, Morty RE.

Glucocorticoids recruit Tgfbr3 and Smad1 to shift transforming growth factor-ß signaling from the Tgfbr1/Smad2/3 axis to the Acvrl1/Smad1 axis in lung fibroblasts.

J Biol Chem. 2013 Dec 17

Knepper J, Schierhorn KL, Becher A, Budt M, Tönnies M, Bauer TT, Schneider P, Neudecker J, Rückert JC, Gruber AD, Suttorp N, Schweiger B, Hippenstiel S, Hocke AC, Wolff T

The novel human influenza A(H7N9) virus is naturally adapted to efficient growth in human lung tissue

MBio. 2013 Oct 8;4(5). pii: e00601-13. doi: 10.1128/mBio.00601-13.

Hocke AC, Becher A, Knepper J, Peter A, Holland G, Tönnies M, Bauer TT, Schneider P, Neudecker J, Muth D, Wendtner CM, Rückert JC, Drosten C, Gruber AD, Laue M, Suttorp N, Hippenstiel S, Wolff T.

Emerging Human Middle East Respiratory Syndrome Coronavirus Causes Widespread Infection and Alveolar Damage in Human Lungs.

Am J Respir Crit Care Med. 2013 Oct 1;188(7):882-886.

Grzesik BA, Vohwinkel C, Morty RE, Mayer K, Herold S, Seeger W, Vadász I

Efficient gene delivery to primary alveolar epithelial cells by nucleofection.

Am J Physiol Lung Cell Mol Physiol 2013, 305: 786-94

Hackstein H, Kranz S, Lippitsch A, Wachtendorf A, Kershaw O, Gruber AD, Michel G, Lohmeyer J, Bein G, Baal N, Herold S.

Modulation of respiratory dendritic cells during Klebsiella pneumonia infection.

Resp Res 2013 Sept 17;14(1):91 [Epub ahead of print].

Herold S, Gabrielli NM, Vadasz I.

Novel concepts of acute lung injury and alveolo-capillary barrier dysfunction.

Am J Physiol Lung Cell Mol Physiol. 13 Sept 2013, DOI: 10.1152/ajplung.00232.2013

Hecker M, Sommer N, Voigtmann H, Pak O, Mohr A, Wolf M, Vadász I, Herold S, Weissmann N, Morty R, Seeger W, Mayer K.

Impact of Short- and Medium-Chain Fatty Acids on Mitochondrial Function in Severe Inflammation.

JPEN J Parenter Enteral Nutr. 2013 May 23.

Hocke AC, Berg J, Becher A, Knepper J, Klauschen F, Tönnies M, Bauer TT, Schneider P, Neudecker J, Rückert JC, Gruber AD, Suttorp N, Hippenstiel S, Wolff T.

Reply to Fujino et al.

J Infect Dis. 2013 Feb 15;207(4):693-5. doi: 10.1093/infdis/jis740. Epub 2012 Nov 29.

Högner, K., Wolff, T., Pleschka, S.  Plog, S., Gruber, A.D., Kalinke, U., Walmrath, H.D., Bodner, J., Gattenlöhner, S., Lewe-Schlosser, P., Matrosovich, M., Seeger, W., Lohmeyer, J. and S. Herold

Macrophage-expressed IFN-ß contributes to apoptotic alveolar epithelial cell injury in severe influenza virus pneumonia.

PLoS Pathog. 2013 Feb;9(2), Epub 2013 Feb 28

Unkel B, Hoegner K, Clausen BE, Lewe-Schlosser P, Bodner J, Gattenloehner S, Seeger W, Lohmeyer J, Herold S

Alveolar epithelial cells orchestrate DC function in murine viral pneumonia.

J Clin Invest 2012, Oct 1;122(10):3652-64

Herold S, Ludwig S, Pleschka S, Wolff T

Apoptosis signaling in influenza virus propagation, innate host defence and lung injury

J Leukoc Biol. 2012 Jul;92(1):75-82. Epub 2012 Feb 17

Koppe U, Högner K, Witzenrath M, Bauer S, Hammerschmidt S, Suttorp N, Herold S, Opitz B.

Streptococcus pneumoniae stimulates a STING- and IFN regulatory factor 3-dependent type I IFN production in macrophages, which regulates RANTES production in macrophages, cocultured alveolar epithelial cells, and mouse lungs.

J Immunol. 2012 Jan 15;188(2):811-7

Pinto R, Herold S, Cakarova L, Hoegner K, Seeger W, Lohmeyer J, Planz O, Pleschka S

Inhibition of influenza virus-induced NF-kappaB and Raf/MEK/ERK activation can reduce both virus titers and cytokine expression simultaneously in vitro and in vivo.

Antiviral Res. 2011 Oct;92(1):45-56. Epub 2011 May 27

Herold S, Tabar TS, Janßen H, Högner, K, Cabanski M, Lewe-Schlosser P, Albrecht J, Driever F, Vadasz I, Seeger W, Steinmüller M, Lohmeyer J

Exudate macrophages attenuate epithelial injury by the release of IL-1 receptor antagonist in gram-negative pneumonia.

Am J Respir Crit Care Med. 2011 May 15;183(10):1380-90. doi: 10.1164/rccm.201009-1431OC. Epub 2011 Jan 28