Transregio SFB-TR 84 “Innate Immunity of the Lung: Mechanisms of Pathogen Attack and Host Defence in Pneumonia“

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A5-Publications

Robak OH, Heimesaat MM, Kruglov AA, Prepens S, Ninnemann J, Gutbier B, Reppe K, Hochrein H, Suter M, Kirschning CJ, Marathe V, Buer J, Hornef MW, Schnare M, Schneider P, Witzenrath M, Bereswill S, Steinhoff U, Suttorp N, Sander LE, Chaput C, Opitz B

Antibiotic treatment-induced secondary IgA deficiency enhances susceptibility to Pseudomonas aeruginosa pneumonia.

J Clin Invest. 2018 Jul 16. pii: 97065

www.jci.org/articles/view/97065

Ugolini M, Gerhard J, Burkert S, Jensen KJ, Georg P, Ebner F, Thada S, Dietert K, Helbig ET, Opitz B, Kurth F, Dittrich N, Sumanlatha G, Blander JM, Gruber AD, Hartmann S, Boekschoten MV, Suttorp N, Müller M, Jungersen G, Schumann RR, Sander LE

Recognition of microbial viability via TLR8 promotes T follicular helper cell differentiation and vaccine responses.

Nat Immunol  2018

www.nature.com/articles/s41590-018-0068-4

Ruiz-Moreno JS, Hamann L, Shah JA, Verbon A, Mockenhaupt FP, Puzianowska-Kuznicka M, Naujoks J, Sander LE, Witzenrath M, Cambier JC, Suttorp N, Schumann RR, Jin L, Hawn TR,  Opitz B,  CAPNETZ Study Group

The common HAQ STING variant impairs cGAS-dependent antibacterial responses and is associated with susceptibility to Legionnaires' disease in humans.

PLoS Pathog. 2018 Jan 3;14(1)

journals.plos.org/plospathogens/article

Ruiz-Moreno JS, Hamann L, Jin L, Sander LE, Puzianowska-Kuznickad M, Cambier JC, Witzenrath M, Schumann RR, Suttorp N, Opitz B, CAPNETZ Study Group

The cGAS/STING pathway detects Streptococcus pneumoniae but is dispensable for anti-pneumococcal defense in mice and humans.

Infect Immun. 2017 Dec 20. pii: IAI.00849-17

iai.asm.org/content/early/2017/12/13/IAI.00849-17.abstract

Dietert K, Gutbier B, Wienhold SM, Reppe K, Jiang X, Yao L, Chaput C, Naujoks J, Brack M, Kupke A, Peteranderl C, Becker S, von Lachner C, Baal N, Slevogt H, Hocke AC, Witzenrath M, Opitz B, Herold S, Hackstein H, Sander LE, Suttorp N, Gruber AD

Spectrum of pathogen- and model-specific histopathologies in mouse models of acute pneumonia.

PLoS One. 2017 Nov 20;12(11):e0188251

www.ncbi.nlm.nih.gov/pubmed/29155867

Naujoks J, Lippmann, J, Suttorp N, Opitz, B

Innate sensing and cell-autonomous resistance pathways in Legionella pneumophila infection.

Int J Med Microbiol. 2017 Oct 27. pii: S1438-4221(17)30306-5.

www.ncbi.nlm.nih.gov/pubmed/29097162

Opitz B

Inflammasome Deficiency Makes Pro-resolving Lipid Mediators Great Again.

Am J Respir Crit Care Med. 2017;196:668-669

www.atsjournals.org/doi/abs/10.1164/rccm.201702-0402ED&

Von Klitzing E, Bereswill S, Heimesaat MM

Multi-drug resistant Pseudomonas aeruginosa induce systemic pro-inflammatory immune responses in colonized mice.

Eur J Microbiol Immunol (Bp). 2017 Sep 11;7(3):200-209

www.ncbi.nlm.nih.gov/pubmed/29034109

Seeberger PH, Pereira CL, Khan N, Xiao G, Diago-Navarro E, Reppe K, Opitz B, Fries BC, Witzenrath M

A semi-synthetic glycoconjugate vaccine candidate for carbapenem-resistant Klebsiella pneumoniae.

Angew Chem Int Ed Engl. 2017 Aug 16

www.pubmed.de/gateway/nlm-pubmed/28815890

Ekmekciu I, von Klitzing E, Fiebiger U, Escher U, Neumann C, Bacher P, Scheffold A, Kühl AA, Bereswill S, Heimesaat MM

Immune responses to broad-spectrum antibiotic treatment and fecal microbiota transplantation in mice.

Front Immunol. 2017 Apr 19;8:397

www.ncbi.nlm.nih.gov/pubmed/28469619

Patel S, Blaauboer SM, Tucker HR, Mansouri S, Ruiz-Moreno JS, Hamann L, Schumann RR, Opitz B, Jin L

The Common R71H-G230A-R293Q Human TMEM173 Is a Null Allele.

J Immunol December 7, 2016, 1601585

www.jimmunol.org/content/early/2016/12/07/jimmunol.1601585.abstract

Kostadinova E, Chaput C, Gutbier B, Lippmann J, Sander LE, Mitchell TJ, Suttorp N, Witzenrath M, Opitz B

NLRP3 protects alveolar barrier integrity by an inflammasome-independent increase of epithelial cell adherence

Sci Rep. 2016 Aug 1;6:30943

www.ncbi.nlm.nih.gov/pubmed/27476670

Rabes A, Suttorp N, Opitz B

Inflammasomes in Pneumococcal Infection: Innate Immune Sensing and Bacterial Evasion Strategies.

Curr Top Microbiol Immunol. 2016;397:215-27

www.ncbi.nlm.nih.gov/pubmed/27460812

Winek K, Engel O, Koduah P, Heimesaat MM, Fischer A, Bereswill S, Dames C, Kershaw O, Gruber AD, Curato C, Oyama N, Meisel C, Meisel A, Dirnagl U

Depletion of cultivatable gut microbiota by broad-spectrum antibiotic pretreatment worsens outcome after murine stroke.

Stroke. 2016 May;47(5):1354-63

www.ncbi.nlm.nih.gov/pubmed/27056982

Winek K, Engel O, Koduah P, Heimesaat MM, Fischer A, Bereswill S, Dames C, Kershaw O, Gruber AD, Curato C, Oyama N, Meisel C, Meisel A, Dirnagl U

Depletion of cultivatable gut microbiota by broad-spectrum antibiotic pretreatment worsens outcome after murine stroke.

Stroke. 2016 May;47(5):1354-63

www.ncbi.nlm.nih.gov/pubmed/27056982

Tabeling C, Noe E, Naujoks J, Doehn JM, Hippenstiel S, Opitz B, Suttorp N, Klopfleisch R, Witzenrath M

PKCα Deficiency in Mice Is Associated with Pulmonary Vascular Hyperresponsiveness to Thromboxane A2 and Increased Thromboxane Receptor Expression.

J Vasc Res. 2015;52(4):279-88

www.ncbi.nlm.nih.gov/pubmed/26890419

Naujoks J, Tabeling C, Dill BD, Hoffmann C, Brown AS, Kunze M, Kempa S, Peter A, Mollenkopf HJ, Dorhoi A, Kershaw O, Gruber AD, Sander LE, Witzenrath M, Herold S, Nerlich A, Hocke AC, van Driel I, Suttorp N, Bedoui S, Hilbi H, Trost M, Opitz B

IFNs Modify the Proteome of Legionella-Containing Vacuoles and Restrict Infection Via IRG1-Derived Itaconic Acid.

PLoS Pathog. 2016 Feb 1;12(2)

www.ncbi.nlm.nih.gov/pubmed/26829557

Fatykhova D, Rabes A, Machnik C, Guruprasad K, Pache F, Berg J, Toennies M, Bauer TT, Schneider P, Schimek M, Eggeling S, Mitchell TJ, Mitchell AM, Hilker R, Hain T, Suttorp N, Hippenstiel S, Hocke AC, Opitz B

Serotype 1 and 8 Pneumococci Evade Sensing by Inflammasomes in Human Lung Tissue.

PLoS One. 2015 Aug 28;10(8):e0137108

www.ncbi.nlm.nih.gov/pubmed/26317436

Müller-Redetzky HC, Wienhold SM, Berg J, Hocke AC, Hippenstiel S, Hellwig K, Gutbier B, Opitz B, Neudecker J, Rückert J, Gruber AC, Kershaw O, Mayer K,  Suttorp N, Witzenrath M

Moxifloxacin is not anti-inflammatory in experimental pneumococcal pneumonia.

J Antimicrob Chemother. 2015 Mar;70(3):830-40

www.ncbi.nlm.nih.gov/pubmed/25406299

Rabes A, Zimmermann S, Reppe K, Lang R, Seeberger PH, Suttorp N, Witzenrath M, Lepenies B, Opitz B

The C-type lectin receptor Mincle binds to Streptococcus pneumoniae but plays a limited role in the anti-pneumococcal innate immune response.

PLoS One. 2015 Feb 6;10(2):e0117022

www.ncbi.nlm.nih.gov/pubmed/25658823

Müller-Redetzky HC, Felten M, Hellwig K, Wienhold SM, Naujoks J, Opitz B, Kershaw O, Gruber AD, Suttorp N, Witzenrath M

Increasing the inspiratory time and I:E ratio during mechanical ventilation aggravates ventilator-induced lung injury in mice.

Critical Care 2015, 19:23

www.ncbi.nlm.nih.gov/pubmed/25888164

Noe E, Tabeling C, Doehn JM, Naujoks J, Opitz B, Hippenstiel S, Witzenrath M, Klopfleisch R

Juvenile megaesophagus in PKCα-deficient mice is associated with an increase in the segment of the distal esophagus lined by smooth muscle cells.

Ann Anat. 2014 Sep;196(5):365-71

www.ncbi.nlm.nih.gov/pubmed/24862691

Tabeling C, Scheer H, Schönrock SM, Runge F, Gutbier B, Lienau J, Hamelmann E, Opitz B, Suttorp N, Mayer K, Behrens GM, Tschernig T, Witzenrath M

Nucleotide oligomerization domain 1 ligation suppressed murine allergen-specific T-cell proliferation and airway hyperresponsiveness.

Am J Respir Cell Mol Biol. 2014 May;50(5):903-11

www.ncbi.nlm.nih.gov/pubmed/24279792

Chaput C, Sander LE, Suttorp N, Opitz B

NOD-Like Receptors in Lung Diseases.

Front Immunol. 2013, 4, 393.

www.ncbi.nlm.nih.gov/pubmed/24312100

Witzenrath M, Pache F, Lorenz D, Koppe U, Schönrock S, Meixenberger K, Dorhoi A, Ma J, Holmes A, Trendelenburg G, Heimesaat MM, Bereswill S, van der Linden M, Tschopp J, Mitchell TJ, Suttorp N, Opitz B.

The NLRP3 Inflammasome is Differentially Activated by Pneumolysin Variants and Contributes to Host Defense in Pneumococcal Pneumonia.

J Immunol. 2011 Jul 1;187(1):434-40. Epub 2011 Jun 6.

www.ncbi.nlm.nih.gov/pubmed/21646297

Eitel J, Suttorp N, Opitz B.

Innate immune recognition and inflammasome activation in Listeria monocytogenes infection.

Front Microbiol. 2011;1: 149

www.ncbi.nlm.nih.gov/pubmed/21607087

Opitz B, van Laak V, Eitel J, Suttorp N.

Innate immune recognition in infectious and noninfectious diseases of the lung.

Am J Respir Crit Care Med. 2010 Jun 15;181(12):1294-309. Epub 2010 Feb 18.

www.ncbi.nlm.nih.gov/pubmed/20167850

Bachem A, Güttler S, Hartung E, Ebstein F, Schäfer M, Tannert A, Salama A, Mavassaghi K, Opitz C, Mages HW, Henn V, Kloetzel PM, Gurka S, Kroczek R

Superior antigen cross-presentation and XCR1 expression define human CD11c+CD141+ cells as homologues of murine CD8+ cells

J Exp Med 207, 1273-81 (2010)

www.ncbi.nlm.nih.gov/pubmed/20479115

Buss C, Opitz B, Hocke AC, Lippmann J, van Laak V, Hippenstiel S, Krüll M, Suttorp N, Eitel J.

Essential role of mitochondrial antiviral signaling, IFN regulatory factor (IRF)3, and IRF7 in Chlamydophila pneumoniae-mediated IFN-beta response and control of bacterial replication in human endothelial cells.

J Immunol. 2010 Mar 15;184(6):3072-8. Epub 2010 Feb 12.

www.ncbi.nlm.nih.gov/pubmed/20154210