A4-Publications
Klabunde B, Wesener A, Bertrams W, Beinborn I, Paczia N, Surmann K, Blankenburg S, Wilhelm J, Serrania J, Knoops K, Elsayed EM, Laakmann K, Jung AL, Kirschbaum A, Hammerschmidt S, Alshaar B, Gisch N, Abu Mraheil M, Becker A, Völker U, Vollmeister E, Benedikter BJ, Schmeck B.
NAD+ metabolism is a key modulator of bacterial respiratory epithelial infections
Nat Commun. 2023 Oct 2;14(1):5818. doi: 10.1038/s41467-023-41372-w. https://pubmed.ncbi.nlm.nih.gov/37783679/
Romero MJ, Yue Q, Singla B, Hamacher J, Sridhar S, Moseley AS, Song C, Mraheil MA, Fischer B, Zeitlinger M, Chakraborty T, Fulton D, Gan L, Annex BH, Csanyi G, Eaton DC, Lucas R.
Direct endothelial ENaC activation mitigates vasculopathy induced by SARS-CoV2 spike protein
Front Immunol 2023 Aug 10;14:1241448. doi: 10.3389/fimmu.2023.1241448. eCollection 2023. https://pubmed.ncbi.nlm.nih.gov/37638055/
Baiomy AA, Serry FE, Kadry AA, Yahya G, Doijad S, Mostafa A, Mraheil MA, El-Ganiny AM
Genome Analysis of Pseudomonas aeruginosa Strains from Chronically Infected Patients with High Levels of Persister Formation
Pathogen 2023 Mar 8;12(3):426.
doi: 10.3390/pathogens12030426. https://pubmed.ncbi.nlm.nih.gov/36986348/
Hegazy A, Mostafa I, Elshaier YAMM, Mahmoud SH, Abo Shama NM, Shehata M, Yahya G, Nasr NF, El-Halawany AM, Ali MA, Ali MA, Mraheil MA, El-Shazly AM, Mostafa A
Robust Antiviral Activity of Santonica Flower Extract (Artemisia cina) against Avian and Human Influenza A Viruses: In Vitro and Chemoinformatic Studies.
ACS Omega 2022 Nov 2;7(45):41212-41223. doi: 10.1021/acsomega.2c04867. eCollection 2022 Nov 15. https://pubmed.ncbi.nlm.nih.gov/36406485/
Banovic F, Schulze S, Abu Mraheil M, Hain T, Chakraborty T, Orian-Rousseau V, Moroniak S, Weiss C, Ishikawa H, Schroten H, Adam R, Schwerk C.
Different Involvement of Vimentin during Invasion by Listeria monocytogenes at the Blood-Brain and the Blood-Cerebrospinal Fluid Barriers In Vitro
Int J Mol Sci 2022 Oct 26;23(21):12908.
doi: 10.3390/ijms232112908. https://pubmed.ncbi.nlm.nih.gov/36361697/
Teubner L, Frantz R, La Pietra L, Hudel M, Bazant J, Lochnit G, Eismann L, Kramer G, Chakraborty T, Abu Mraheil M.
SecA2 Associates with Translating Ribosomes and Contributes to the Secretion of Potent IFN-β Inducing RNAs
Int J Mol Sci 2022 Nov 30;23(23):15021.
doi: 10.3390/ijms232315021. https://pubmed.ncbi.nlm.nih.gov/36499346/
Hönzke K, Obermayer B, Mache C, Fathykova D, Kessler M, Dökel S, Wyler E, Baumgardt M, Löwa A, Hoffmann K, Graff P, Schulze J, Mieth M, Hellwig K, Demir Z, Biere B, Brunotte L, Mecate-Zambrano A, Bushe J, Dohmen M, Hinze C, Elezkurtaj S, Tönnies M, Bauer TT, Eggeling S, Tran HL, Schneider P, Neudecker J, Rückert JC, Schmidt-Ott KM, Busch J, Klauschen F, Horst D, Radbruch H, Radke J, Heppner F, Corman VM, Niemeyer D, Müller MA, Goffinet C, Mothes R, Pascual-Reguant A, Hauser AE, Beule D, Landthaler M, Ludwig S, Suttorp N, Witzenrath M, Gruber AD, Drosten C, Sander LE, Wolff T, Hippenstiel S, Hocke AC
Human lungs show limited permissiveness for SARS-CoV-2 due to scarce ACE2 levels but virus-induced expansion of inflammatory macrophages
Eur Respir J. 2022 Dec 1;60(6):2102725. doi: 10.1183/13993003.02725-2021.
https://pubmed.ncbi.nlm.nih.gov/35728978/
Hülsemann M, Wiebach J, Drude NI, Kniffert S, Behm L, Hönzke K, Baumgardt M, Hippenstiel S, Hocke AC, Dirnagl U, Tölch U.
Introducing quality measures in an academic research consortium: Lessons and recommendation from implementing an ad hoc quality management system for organ model research
EMBO Rep. 2022 Aug 3;23(8):e55095. doi: 10.15252/embr.202255095. Epub 2022 Jul 25. https://pubmed.ncbi.nlm.nih.gov/35876564/
Pennitz P, Kirsten H, Friedrich VD, Wyler E, Goekeri C, Obermayer B, Heinz GA, Mashreghi MF, Büttner M, Trimpert J, Landthaler M, Suttorp N, Hocke AC, Hippenstiel S, Tönnies M, Scholz M, Kuebler WM, Witzenrath M, Hoenzke K, Nouailles G.
A pulmonologist's guide to perform and analyse cross-species single lung cell transcriptomics
Eur Respir Rev. 2022 Jul 27;31(165):220056. doi: 10.1183/16000617.0056-2022. https://pubmed.ncbi.nlm.nih.gov/35896273/
Wygrecka M, Birnhuber A, Seeliger B, Michalick L, Pak O, Schultz AS, Schramm F, Zacharias M, Gorkiewicz G, David S, Welte T, Schmidt JJ, Weissmann N, Schermuly RT, Barreto G, Schaefer L, Markart P, Brack MC, Hippenstiel S, Kurth F, Sander LE, Witzenrath M, Kuebler WM, Kwapiszewska G, Preissner KT.
Altered fibrin clot structure and dysregulated fibrinolysis contribute to thrombosis risk in severe COVID-19
Blood Adv. 2022 Feb 8;6(3):1074-1087. doi: 10.1182/bloodadvances.2021004816. pubmed.ncbi.nlm.nih.gov/34861681/
Georg P, Astaburuaga-García R, Bonaguro L, Brumhard S, Michalick L, Lippert LJ, Kostevc T, Gäbel C, Schneider M, Streitz M, Demichev V, Gemünd I, Barone M, Tober-Lau P, Helbig ET, Hillus D, Petrov L, Stein J, Dey HP, Paclik D, Iwert C, Mülleder M, Aulakh SK, Djudjaj S, Bülow RD, Mei HE, Schulz AR, Thiel A, Hippenstiel S, Saliba AE, Eils R, Lehmann I, Mall MA, Stricker S, Röhmel J, Corman VM, Beule D, Wyler E, Landthaler M, Obermayer B, von Stillfried S, Boor P, Demir M, Wesselmann H, Suttorp N, Uhrig A, Müller-Redetzky H, Nattermann J, Kuebler WM, Meisel C, Ralser M, Schultze JL, Aschenbrenner AC, Thibeault C, Kurth F, Sander LE, Blüthgen N, Sawitzki B; PA-COVID-19 Study Group.
Complement activation induces excessive T cell cytotoxicity in severe COVID-19
Cell. 2022 Feb 3;185(3):493-512.e25. doi: 10.1016/j.cell.2021.12.040. Epub 2021 Dec 28. pubmed.ncbi.nlm.nih.gov/35032429/
Demichev V, Tober-Lau P, Nazarenko T, Lemke O, Kaur Aulakh S, Whitwell HJ, Röhl A, Freiwald A, Mittermaier M, Szyrwiel L, Ludwig D, Correia-Melo C, Lippert LJ, Helbig ET, Stubbemann P, Olk N, Thibeault C, Grüning NM, Blyuss O, Vernardis S, White M, Messner CB, Joannidis M, Sonnweber T, Klein SJ, Pizzini A, Wohlfarter Y, Sahanic S, Hilbe R, Schaefer B, Wagner S, Machleidt F, Garcia C, Ruwwe-Glösenkamp C, Lingscheid T, Bosquillon de Jarcy L, Stegemann MS, Pfeiffer M, Jürgens L, Denker S, Zickler D, Spies C, Edel A, Müller NB, Enghard P, Zelezniak A, Bellmann-Weiler R, Weiss G, Campbell A, Hayward C, Porteous DJ, Marioni RE, Uhrig A, Zoller H, Löffler-Ragg J, Keller MA, Tancevski I, Timms JF, Zaikin A, Hippenstiel S, Ramharter M, Müller-Redetzky H, Witzenrath M, Suttorp N, Lilley K, Mülleder M, Sander LE; PA-COVID-19 Study group; Kurth F, Ralser M.
A proteomic survival predictor for COVID-19 patients in intensive care.
PLOS Digit Health. 2022 Jan 18;1(1):e0000007. doi: 10.1371/journal.pdig.0000007. https://pubmed.ncbi.nlm.nih.gov/36812516/
Al-Karmalawy AA, Soltane R, Abo Elmaaty A, Tantawy MA, Antar SA, Yahya G, Chrouda A, Pashameah RA, Mustafa M, Abu Mraheil M, Mostafa A.
Coronavirus Disease (COVID-19) Control between Drug Repurposing and Vaccination: A Comprehensive Overview
Vaccines (Basel). 2021 Nov 12;9(11):1317. doi: 10.3390/vaccines9111317. https://pubmed.ncbi.nlm.nih.gov/34835248/
Schulze J, Mache C, Balázs A, Frey D, Niemeyer D, Olze H, Dommerich S, Drosten C, Hocke AC, Mall MA, Hippenstiel S, Wolff T.
Analysis of SARS-CoV-2 replication in explant cultures of the human upper respiratory tract reveals broad tissue tropism of wild-type and B.1.1.7 variant viruses.
J Infect Dis. 2021 Oct 15:jiab523. doi: 10.1093/infdis/jiab523. Epub ahead of print. PMID: 34651643; PMCID: PMC8524635. pubmed.ncbi.nlm.nih.gov/34651643/
Loyal L, Braun J, Henze L, Kruse B, Dingeldey M, Reimer U, Kern F, Schwarz T, Mangold M, Unger C, Dörfler F, Kadler S, Rosowski J, Gürcan K, Uyar-Aydin Z, Frentsch M, Kurth F, Schnatbaum K, Eckey M, Hippenstiel S, Hocke A, Müller MA, Sawitzki B, Miltenyi S, Paul F, Mall MA, Wenschuh H, Voigt S, Drosten C, Lauster R, Lachman N, Sander LE, Corman VM, Röhmel J, Meyer-Arndt L, Thiel A, Giesecke-Thiel C.
Cross-reactive CD4+ T cells enhance SARS-CoV-2 immune responses upon infection and vaccination.
Science. 2021 Aug 31:eabh1823. doi: 10.1126/science.abh1823. Epub ahead of print. PMID: 34465633. pubmed.ncbi.nlm.nih.gov/34465633/
Demichev V, Tober-Lau P, Lemke O, Nazarenko T, Thibeault C, Whitwell H, Röhl A, Freiwald A, Szyrwiel L, Ludwig D, Correia-Melo C, Aulakh SK, Helbig ET, Stubbemann P, Lippert LJ, Grüning NM, Blyuss O, Vernardis S, White M, Messner CB, Joannidis M, Sonnweber T, Klein SJ, Pizzini A, Wohlfarter Y, Sahanic S, Hilbe R, Schaefer B, Wagner S, Mittermaier M, Machleidt F, Garcia C, Ruwwe-Glösenkamp C, Lingscheid T, Bosquillon de Jarcy L, Stegemann MS, Pfeiffer M, Jürgens L, Denker S, Zickler D, Enghard P, Zelezniak A, Campbell A, Hayward C, Porteous DJ, Marioni RE, Uhrig A, Müller-Redetzky H, Zoller H, Löffler-Ragg J, Keller MA, Tancevski I, Timms JF, Zaikin A, Hippenstiel S, Ramharter M, Witzenrath M, Suttorp N, Lilley K, Mülleder M, Sander LE; PA-COVID-19 Study group, Ralser M, Kurth F.
A time-resolved proteomic and prognostic map of COVID-19
Cell Syst. 2021 Jun 14:S2405-4712(21)00160-5. doi: 10.1016/j.cels.2021.05.005. Epub ahead of print. PMID: 34139154; PMCID: PMC8201874. pubmed.ncbi.nlm.nih.gov/34139154/
Bertrams W, Griss K, Han M, Seidel K, Hippenstiel S, Suttorp N, Finkernagel F, Wilhelm J, Vogelmeier CF, Schmeck B.
Transcriptional analysis identifies potential biomarkers and molecular regulators in acute malaria infection
Life Sci. 2021 Apr 1;270:119158. doi: 10.1016/j.lfs.2021.119158. Epub 2021 Feb 2. PMID: 33545200. pubmed.ncbi.nlm.nih.gov/33545200/
Gonzales J, Chakraborty T, Romero M, Mraheil MA, Kutlar A, Pace B, Lucas R.
Streptococcus pneumoniae and Its Virulence Factors H2O2 and Pneumolysin Are Potent Mediators of the Acute Chest Syndrome in Sickle Cell Disease
Toxins (Basel). 2021 Feb 17;13(2):157. doi: 10.3390/toxins13020157. https://pubmed.ncbi.nlm.nih.gov/33671422/
Michalick L, Weidenfeld S, Grimmer B, Fatykhova D, Solymosi PD, Behrens F, Dohmen M, Brack MC, Schulz S, Thomasch E, Simmons S, Müller-Redetzky H, Suttorp N, Kurth F, Neudecker J, Toennies M, Bauer TT, Eggeling S, Corman VM, Hocke AC, Witzenrath M, Hippenstiel S, Kuebler WM.
Plasma mediators in patients with severe COVID-19 cause lung endothelial barrier failure
Eur Respir J. 2020 Nov 5;2002384. doi: 10.1183/13993003.02384-2020. Online ahead of print.
Mraheil MA, Toque HA, La Pietra L, Hamacher J, Phanthok T, Verin AD, Gonzales J, Su Y, Fulton D, Eaton DC, Chakraborty T, Lucas R.
Dual Role of Hydrogen Peroxide as an Oxidant in Pneumococcal Pneumonia.
Lucas R, Hadizamani Y, Gonzales J, Gorshkov B, Bodmer T, Berthiaume Y, Moehrlen U, Lode H, Huwer H, Hudel M, Mraheil MA, Toque HAF, Chakraborty T, Hamacher J.
Impact of Bacterial Toxins in the Lungs
Toxins (Basel). 2020 Apr 2;12(4):223. doi: 10.3390/toxins12040223. https://pubmed.ncbi.nlm.nih.gov/32252376/
Frantz R, Teubner L, Schultze T, La Pietra L, Müller C, Gwozdzinski K, Pillich H, Hain T, Weber-Gerlach M, Panagiotidis GD, Mostafa A, Weber F, Rohde M, Pleschka S, Chakraborty T, Abu Mraheil M.
The secRNome of Listeria monocytogenes Harbors Small Noncoding RNAs That Are Potent Inducers of Beta Interferon.
Yang G, Pillich H, White R, Czikora I, Pochic I, Yue Q, Hudel M, Gorshkov B, Verin A, Sridhar S, Isales CM, Eaton DC, Hamacher J, Chakraborty T, Lucas R
Listeriolysin O causes ENaC dysfunction in human airway epithelial cells.
Listeriolysin O causes ENaC dysfunction in human airway epithelial cells
Puri M, La Pietra L, Mraheil MA, Lucas R, Chakraborty T, Pillich H.
Listeriolysin O regulates the expression of optineurin, an autophagy adaptor that inhibits the growth of Listeria monocytogenes.
Toxins (Basel). 2017; 9; pii: E273.
Czikora I, Alli AA, Sridhar S, Matthay MA, Pillich H, Hudel M, Berisha B, Gorshkov B, Romero MJ, Gonzales J, Wu G, Huo Y, Su Y, Verin AD, Fulton D, Chakraborty T, Eaton DC, Lucas R.
Epithelial Sodium Channel-https://www.ncbi.nlm.nih.gov/pubmed/28785264
Chen F, Wang Y, Rafikov R, Haigh S, Zhi WB, Kumar S, Doulias PT, Rafikova O, Pillich H, Chakraborty T, Lucas R, Verin AD, Catravas JD, She JX, Black SM, Fulton DJ.
RhoA S-nitrosylation as a regulatory mechanism influencing endothelial barrier function in response to G+-bacterial toxins.
Biochem Pharmacol. 2016 Dec 22. pii: S0006-2952(16)30494-4.
Maurer J, Hupp S, Bischoff C, Foertsch C, Mitchell TJ, Chakraborty T, Iliev AI.
Distinct Neurotoxicity Profile of Listeriolysin O from Listeria monocytogenes.
Toxins (Basel). 2017; 9(1), pii: E34.
Pillich H, Loose M, Zimmer KP, Chakraborty T
Diverse roles of endoplasmic reticulum stress sensors in bacterial infection.
Mol Cell Pediatr. 2016 Dec;3(1):9 www.ncbi.nlm.nih.gov/pubmed/26883353
Lucas R, Yue Q, Alli A, Duke BJ, Al-Khalili O, Thai TL, Hamacher J, Sridhar S, Lebedyeva I, Su H, Tzotzos S, Fischer B, Gameiro AF, Loose M, Chakraborty T, Shabbir W, Aufy M, Lemmens-Gruber R, Eaton DC, Czikora I.
The Lectin-like Domain of TNF Increases ENaC Open Probability through a Novel Site at the Interface between the Second Transmembrane and C-terminal Domains of the α-Subunit.
J Biol Chem. 2016; 291:23440-23451.
Loose M, Pillich H, Chakraborty T.
Fisetin protects against Listeria monocytogenes infection by reducing the listeriolysin O production.
J Infect Dis. 2015; pii:jiv437.
http://jid.oxfordjournals.org/content/early/2015/09/06/infdis.jiv437.long
Loose M, Hudel M, Zimmer KP, Garcia E, Hammerschmidt S, Lucas R, Chakraborty T, Pillich H
Pneumococcal hydrogen peroxide-induced stress signaling regulates inflammatory genes.
J Infect Dis. 2015 Jan 15;211(2):306-16
Czikora I, Alli A, Bao HF, Kaftan D, Sridhar S, Apell HJ, Gorshkov B, White R, Zimmermann A, Wendel A, Pauly-Evers M, Hamacher J, Garcia-Gabay I, Fischer B, Verin A, Bagi Z, Pittet JF, Shabbir W, Lemmens-Gruber R, Chakraborty T, Lazrak A, Matthay MA, Eato
A novel tumor necrosis factor-mediated mechanism of direct epithelial sodium channel activation.
Am J Respir Crit Care Med. 2014 Sep 1;190(5):522-32
Czikora I, Sridhar S, Gorshkov B, Alieva IB, Kasa A, Gonzales J, Potapenko O, Umapathy NS, Pillich H, Rick FG, Block NL, Verin AD, Chakraborty T, Mattay MA, Schally AV, Lucas R.
Protective effect of growth hormone-releasing hormone agonist in bacterial toxin-induced pulmonary barrier dysfunction.
Front Physiol. 2014; 5:259.
Lucas R, Czikora I, Sridhar S, Zemskov EA, Oseghale A, Circo S, Cederbaum SD, Chakraborty T, Fulton DJ, Caldwell RW, Romero MJ.
Arginase 1: an unexpected mediator of pulmonary capillary barrier dysfunction in models of acute lung injury.
Front Immunol. 2013, 4:228
Lucas R, Czikora I, Sridhar S, Zemskov E, Gorshkov B, Siddaramappa U, Oseghale A, Lawson J, Verin A, Rick FG, Block NL, Pillich H, Romero M, Leustik M, Schally AV, Chakraborty T.
Mini-review: Novel therapeutic strategies to blunt actions of pneumolysin in the lungs.
Toxins (Basel). 2013, 5:1244-1260.
Lucas R, Yang G, Gorshkov BA, Zemskov EA, Sridhar S, Umapathy NS, Jezierska-Drutel A, Alieva IB, Leustik M, Hossain H, Fischer B, Catravas JD, Verin AD, Pittet JF, Caldwell RB, Mitchell TJ, Cederbaum SD, Fulton DJ, Matthay MA, Caldwell RW, Romero MJ, Chak
Protein Kinase C-a and Arginase I Mediate Pneumolysin-Induced Pulmonary Endothelial Hyperpermeability.
Am J Respir Cell Mol Biol, 2012, May 10. [Epub ahead of print]
Pillich H, Loose M, Zimmer KP, Chakraborty T
Activation of the unfolded protein response by Listeria monocytogenes
Cell Microbiol. 2012; 14:949-964.
Lucas R, Sridhar S, Rick FG, Gorshkov B, Umapathy NS, Yang G, Oseghale A, Verin AD, Chakraborty T, Matthay MA, Zemskov EA, White R, Block NL, Schally AV.
Agonist of growth hormone-releasing hormone reduces pneumolysin-induced pulmonary permeability edema.
Proc Natl Acad Sci U S A, 2012, 109:2084-2089.
mikrobio.med.uni-giessen.de