Transregio SFB-TR 84 “Innate Immunity of the Lung: Mechanisms of Pathogen Attack and Host Defence in Pneumonia“


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Yang G, Pillich H, White R, Czikora I, Pochic I, Yue Q, Hudel M, Gorshkov B, Verin A, Sridhar S, Isales CM, Eaton DC, Hamacher J, Chakraborty T, Lucas R

Listeriolysin O causes ENaC dysfunction in human airway epithelial cells.

Listeriolysin O causes ENaC dysfunction in human airway epithelial cells

Puri M, La Pietra L, Mraheil MA, Lucas R, Chakraborty T, Pillich H.

Listeriolysin O Regulates the Expression of Optineurin, an Autophagy Adaptor That Inhibits the Growth of Listeria monocytogenes.

Toxins (Basel). 2017; 9; pii: E273.

Czikora I, Alli AA, Sridhar S, Matthay MA, Pillich H, Hudel M, Berisha B, Gorshkov B, Romero MJ, Gonzales J, Wu G, Huo Y, Su Y, Verin AD, Fulton D, Chakraborty T, Eaton DC, Lucas R.

Epithelial Sodium Channel-α Mediates the Protective Effect of the TNF-Derived TIP Peptide in Pneumolysin-Induced Endothelial Barrier Dysfunction.

Front Immunol. 2017; 8:842.

Chen F, Wang Y, Rafikov R, Haigh S, Zhi WB, Kumar S, Doulias PT, Rafikova O, Pillich H, Chakraborty T, Lucas R, Verin AD, Catravas JD, She JX, Black SM, Fulton DJ.

RhoA S-nitrosylation as a regulatory mechanism influencing endothelial barrier function in response to G+-bacterial toxins.

Biochem Pharmacol. 2016 Dec 22. pii: S0006-2952(16)30494-4.

Maurer J, Hupp S, Bischoff C, Foertsch C, Mitchell TJ, Chakraborty T, Iliev AI.

Distinct Neurotoxicity Profile of Listeriolysin O from Listeria monocytogenes.

Toxins (Basel). 2017; 9(1), pii: E34.

Pillich H, Loose M, Zimmer KP, Chakraborty T

Diverse roles of endoplasmic reticulum stress sensors in bacterial infection.

Mol Cell Pediatr. 2016 Dec;3(1):9

Lucas R, Yue Q, Alli A, Duke BJ, Al-Khalili O, Thai TL, Hamacher J, Sridhar S, Lebedyeva I, Su H, Tzotzos S, Fischer B, Gameiro AF, Loose M, Chakraborty T, Shabbir W, Aufy M, Lemmens-Gruber R, Eaton DC, Czikora I.

The Lectin-like Domain of TNF Increases ENaC Open Probability through a Novel Site at the Interface between the Second Transmembrane and C-terminal Domains of the α-Subunit.

J Biol Chem. 2016; 291:23440-23451.

Pillich H, Loose M, Zimmer KP, Chakraborty T

Diverse roles of endoplasmic reticulum stress sensors in bacterial infection.

Mol Cell Pediatr., 2016, 3(1):9

Loose M, Pillich H, Chakraborty T.

Fisetin protects against Listeria monocytogenes infection by reducing the listeriolysin O production.

J Infect Dis. 2015; pii:jiv437.

Loose M, Hudel M, Zimmer KP, Garcia E, Hammerschmidt S, Lucas R, Chakraborty T, Pillich H

Pneumococcal hydrogen peroxide-induced stress signaling regulates inflammatory genes.

J Infect Dis. 2015 Jan 15;211(2):306-16

Czikora I, Alli A, Bao HF, Kaftan D, Sridhar S, Apell HJ, Gorshkov B, White R, Zimmermann A, Wendel A, Pauly-Evers M, Hamacher J, Garcia-Gabay I, Fischer B, Verin A, Bagi Z, Pittet JF, Shabbir W, Lemmens-Gruber R, Chakraborty T, Lazrak A, Matthay MA, Eaton DC, Lucas R

A novel tumor necrosis factor-mediated mechanism of direct epithelial sodium channel activation.

Am J Respir Crit Care Med. 2014 Sep 1;190(5):522-32

Czikora I, Sridhar S, Gorshkov B, Alieva IB, Kasa A, Gonzales J, Potapenko O, Umapathy NS, Pillich H, Rick FG, Block NL, Verin AD, Chakraborty T, Mattay MA, Schally AV, Lucas R.

Protective effect of growth hormone-releasing hormone agonist in bacterial toxin-induced pulmonary barrier dysfunction.

Front Physiol. 2014; 5:259.

Lucas R, Czikora I, Sridhar S, Zemskov EA, Oseghale A, Circo S, Cederbaum SD, Chakraborty T, Fulton DJ, Caldwell RW, Romero MJ.

Arginase 1: an unexpected mediator of pulmonary capillary barrier dysfunction in models of acute lung injury.

Front Immunol. 2013, 4:228

Lucas R, Czikora I, Sridhar S, Zemskov E, Gorshkov B, Siddaramappa U, Oseghale A, Lawson J, Verin A, Rick FG, Block NL, Pillich H, Romero M, Leustik M, Schally AV, Chakraborty T.

Mini-review: Novel therapeutic strategies to blunt actions of pneumolysin in the lungs.

Toxins (Basel). 2013, 5:1244-1260.

Lucas R, Yang G, Gorshkov BA, Zemskov EA, Sridhar S, Umapathy NS, Jezierska-Drutel A, Alieva IB, Leustik M, Hossain H, Fischer B, Catravas JD, Verin AD, Pittet JF, Caldwell RB, Mitchell TJ, Cederbaum SD, Fulton DJ, Matthay MA, Caldwell RW, Romero MJ, Chak

Protein Kinase C-a and Arginase I Mediate Pneumolysin-Induced Pulmonary Endothelial Hyperpermeability.

Am J Respir Cell Mol Biol, 2012, May 10. [Epub ahead of print]

Pillich H, Loose M, Zimmer KP, Chakraborty T

Activation of the unfolded protein response by Listeria monocytogenes

Cell Microbiol. 2012; 14:949-964.

Lucas R, Sridhar S, Rick FG, Gorshkov B, Umapathy NS, Yang G, Oseghale A, Verin AD, Chakraborty T, Matthay MA, Zemskov EA, White R, Block NL, Schally AV.

Agonist of growth hormone-releasing hormone reduces pneumolysin-induced pulmonary permeability edema.

Proc Natl Acad Sci U S A, 2012, 109:2084-2089.

Meixenberger K, Pache F, Eitel J, Schmeck B, Hippenstiel S, Slevogt H, N´Guessan P, Witzenrath M, Netea MG, Chakraborty T, Suttorp N, Opitz B.

Listeria monocytogenes-infected human peripheral blood mononuclear cells produce IL-1beta,depending on listeriolysin O and NLRP3.

J Immunol. 2010 Jan 15;184(2):922-30. Epub 2009 Dec 11.