Transregio SFB-TR 84 “Innate Immunity of the Lung: Mechanisms of Pathogen Attack and Host Defence in Pneumonia“

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A1-Subproject

Regulation of antibacterial defense in the lung by the alarmin IL-33
(Opitz / Diefenbach )

 

We plan to examine the precise mechanism by which the alarmin IL-33 negatively regulates the immune response during pneumonia. We will focus on processes that control lung epithelial cell-mediated immunity, regeneration and repair by investigating how IL-33 affects the alveolar epithelium both indirectly as well as directly.

We will

(I) identify the cellular sources of IL-33 during pneumococcal infection;

(II) analyze the effects of IL-33 on (innate) lymphoid cells-mediated antibacterial defense, regeneration and repair;

(III) investigate the effects of IL-33 on epithelial cells, and (IV) test if treatment with recombinant sST2 positively affects antibacterial defense and repair during pneumonia.