Transregional Collaborative Research Center SFB-TR 84 - “Innate Immunity of the Lung: Mechanisms of Pathogen Attack and Host Defence in Pneumonia“

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Area A

Pathogen recognition in the lung and initiation of innate immune response

 

Area A is dedicated to the investigation of early events in host-pathogen interaction in the lung and addresses consequences of these processes on the signatures of the resulting innate immune response.

Project A01 (Bauer/Opitz) dissects the function of TIR8- and ST2-related mechanism in inflammation and repair in pneumonia. The main goal of project A02 (Wygrecka/Preissner) is to decipher the role of host-derived extracellular nucleic acids, enolase and histones released from dying cells or expelled from neutrophils in the processes of NETosis, for the regulation of innate immunity in pneumonia. In project A04 (Pillich/Chakraborty) the role of the autophagy and UPR (effects of transient shutdown on protein translation and its protective effects) and mechanisms as well as functional consequences of microvilli loss will be examined in S.p. infection. A05 (Opitz/Chaput/Heimesaat) uses innovative in vivo models to investigate if and how antibacterial immunity in the lung is influenced systemically by the intestinal microbiota and/or locally by the microbiota of the respiratory tract. Project A06 (Krasteva-Christ/Kummer) will test the hypothesis that airway epithelial cells utilize canonical taste receptors for pathogen recognition and, upon stimulation, either directly respond in a cell-autonomous manner or modulate mucociliary clearance by paracrine release of acetylcholine or ATP.

Abbreviations: B/Gi-M, Berlin/Gießen-Marburg; B, Berlin; Gi-M, Gießen-Marburg; DAMP, danger-associated molecular pattern; MAMP, microbe-associated molecular patterns; TIR, TLR/interleukin-1 receptor; IL-33, Interleukin-33; Casp-1, Caspase-1; ILC2, type 2 innate lymphoid cells; PRR, pattern recognition receptors, NET, neutrophil extracellular traps; EC, endothelial cell; MVID, microvilli inclusion bodies; UPR, unfolded protein response; Myo5b, myosin VB; CFTR, cystic fibrosis transmembrane conductance regulator; ENaC, epithelial Na+ channel; MDR, multidrug resistant; ABiotics, antibiotics; AECs, alveolar epithelial cells, BECs, bronchial epithelial cells; VAChT, vesicular acetylcholine transporter; ACh, acetylcholine; TasR, taste receptor; PLC, phospholipase C.